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WO1986007059A3 - Composes d'oxodiazine - Google Patents

Composes d'oxodiazine

Info

Publication number
WO1986007059A3
WO1986007059A3 PCT/JP1986/000241 JP8600241W WO8607059A3 WO 1986007059 A3 WO1986007059 A3 WO 1986007059A3 JP 8600241 W JP8600241 W JP 8600241W WO 8607059 A3 WO8607059 A3 WO 8607059A3
Authority
WO
WIPO (PCT)
Prior art keywords
alkoxy
alkyl
halogen
phenyl
agents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP1986/000241
Other languages
English (en)
Other versions
WO1986007059A2 (fr
Inventor
Hideki Oa
Minoru Obata
Tsutomu Yamanaka
Hiroshi Mikashima
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsubishi Tanabe Pharma Corp
Original Assignee
Yoshitomi Pharmaceutical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yoshitomi Pharmaceutical Industries Ltd filed Critical Yoshitomi Pharmaceutical Industries Ltd
Priority to DE8686902913T priority Critical patent/DE3666434D1/de
Priority to AT86902913T priority patent/ATE47393T1/de
Priority to JP61502620A priority patent/JPS63500031A/ja
Publication of WO1986007059A2 publication Critical patent/WO1986007059A2/fr
Publication of WO1986007059A3 publication Critical patent/WO1986007059A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Composé d'oxodiazine de formule (I) ou son sel d'addition d'acide pharmaceutiquement acceptable, dans laquelle chacun de R1 et R2 est hydrogène, halogène, C1-4 alkyle, C1-4 alkoxy, C1-4 alkoxy-C1-4 alkoxy, phényle C1-4 alkyle-oxy qui peut être éventuellement substitué par au moins un substituant sélectionné dans le groupe composé d'un halogène, C1-4 alkyle et C1-4 alkoxy sur le noyau de phényle, ou un phényle qui peut être substitué par au moins un substituant sélectionné dans le groupe composé d'un halogène, C1-4 alkyle et C1-4 alkoxy sur le noyau de phényle; X est -S-, -CH=N- ou bien -C(R3)=C(R4)-, ou chacun de R3 et R4 est hydrogène, halogène, C1-4 alkyle, C1-4 alkoxy, C1-4 alkoxy-C1-4 alkoxy ou phényle -C1-4 alkyle-oxy qui peut être éventuellement substitué par au moins un substituant sélectionné dans le groupe composé d'un halogène, C1-4 alkyle et C1-4 alkoxy sur le noyau de phényle; et un de A et B est oxygène, soufre ou -NH- et l'autre est -C(R5) (R6)-, où chacun de R5 et R6 est hydrogène ou C1-4 alkyle. Ces composés sont utiles comme agents antithrombotiques, agents anti-angineux, agents améliorant la circulation coronarienne, agents améliorant la circulation cérébrale, agents améliorant la circulation périphérique, analgésiques et agents anti-inflammatoires.
PCT/JP1986/000241 1985-05-25 1986-05-12 Composes d'oxodiazine Ceased WO1986007059A2 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
DE8686902913T DE3666434D1 (de) 1985-05-25 1986-05-12 Oxodiazine compounds
AT86902913T ATE47393T1 (de) 1985-05-25 1986-05-12 Oxodiazinverbindungen.
JP61502620A JPS63500031A (ja) 1985-05-25 1986-05-12 オキソジアジン化合物

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP60/112715 1985-05-25
JP11271585 1985-05-25

Publications (2)

Publication Number Publication Date
WO1986007059A2 WO1986007059A2 (fr) 1986-12-04
WO1986007059A3 true WO1986007059A3 (fr) 1987-03-12

Family

ID=14593699

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP1986/000241 Ceased WO1986007059A2 (fr) 1985-05-25 1986-05-12 Composes d'oxodiazine

Country Status (4)

Country Link
US (1) US4713381A (fr)
EP (1) EP0226641B1 (fr)
DE (1) DE3666434D1 (fr)
WO (1) WO1986007059A2 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9009469D0 (en) * 1990-04-27 1990-06-20 British Bio Technology Compounds
US7148353B2 (en) * 2003-10-28 2006-12-12 Sepracor Inc. Imidazo[1,2-a] pyridine anxiolytics
US20120220581A1 (en) 2009-10-30 2012-08-30 Janssen-Cilag, S.A. IMIDAZO[1,2-b]PYRIDAZINE DERIVATIVES AND THEIR USE AS PDE10 INHIBITORS
MX2012006994A (es) 2009-12-18 2012-07-03 Mitsubishi Tanabe Pharma Corp Agente antiplaquetas novedoso.
AR080754A1 (es) 2010-03-09 2012-05-09 Janssen Pharmaceutica Nv Derivados de imidazo (1,2-a) pirazina y su uso como inhibidores de pde10
EP2723744B1 (fr) 2011-06-27 2016-03-23 Janssen Pharmaceutica, N.V. Dérivés de 1-aryl-4-méthyl-[1,2,4]triazolo[4,3-a]-quinoxaline
RU2657540C2 (ru) 2012-06-26 2018-06-14 Янссен Фармацевтика Нв Комбинации, содержащие ингибиторы pde 2, такие как 1-арил-4-метил-[1,2,4]триазоло[4,3-а]хиноксалиновые соединения, и ингибиторы pde 10, для применения в лечении неврологических или метаболических расстройств
ES2607184T3 (es) 2012-07-09 2017-03-29 Janssen Pharmaceutica, N.V. Inhibidores de la enzima fosfodiesterasa 10
EP3966201A4 (fr) * 2019-05-09 2023-01-18 The Feinstein Institutes for Medical Research Thiosemicarbazates et leurs utilisations

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0085227A1 (fr) * 1981-11-12 1983-08-10 Imperial Chemical Industries Plc Dérivés de thiadiazine ainsi que compositions pharmaceutiques les contenant
EP0120589A1 (fr) * 1983-02-25 1984-10-03 Fujisawa Pharmaceutical Co., Ltd. Composés imidazo-hétérocycliques, procédé pour leur préparation et compositions pharmaceutiques les contenant
EP0180158A1 (fr) * 1984-10-29 1986-05-07 Yoshitomi Pharmaceutical Industries, Ltd. Composé thiadiazinique, procédé pour sa préparation et compositions pharmaceutiques le contenant

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0085227A1 (fr) * 1981-11-12 1983-08-10 Imperial Chemical Industries Plc Dérivés de thiadiazine ainsi que compositions pharmaceutiques les contenant
EP0120589A1 (fr) * 1983-02-25 1984-10-03 Fujisawa Pharmaceutical Co., Ltd. Composés imidazo-hétérocycliques, procédé pour leur préparation et compositions pharmaceutiques les contenant
EP0180158A1 (fr) * 1984-10-29 1986-05-07 Yoshitomi Pharmaceutical Industries, Ltd. Composé thiadiazinique, procédé pour sa préparation et compositions pharmaceutiques le contenant

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
No relevant documents have been disclosed. *

Also Published As

Publication number Publication date
WO1986007059A2 (fr) 1986-12-04
EP0226641B1 (fr) 1989-10-18
US4713381A (en) 1987-12-15
EP0226641A1 (fr) 1987-07-01
DE3666434D1 (de) 1989-11-23

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