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WO1986006494A3 - Means for in vitro diagnostic of malignant cells originating from the digestive tube - Google Patents

Means for in vitro diagnostic of malignant cells originating from the digestive tube

Info

Publication number
WO1986006494A3
WO1986006494A3 PCT/FR1986/000150 FR8600150W WO8606494A3 WO 1986006494 A3 WO1986006494 A3 WO 1986006494A3 FR 8600150 W FR8600150 W FR 8600150W WO 8606494 A3 WO8606494 A3 WO 8606494A3
Authority
WO
WIPO (PCT)
Prior art keywords
malignant cells
digestive tube
cells originating
vitro diagnostic
vitro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/FR1986/000150
Other languages
French (fr)
Other versions
WO1986006494A2 (en
WO1986006494A1 (en
Inventor
Daniel Louvard
Brigitte Doudouet
Sylvie Robine
Monique Arpin
Eric Pringault
Alphonse Garcia
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centre National de la Recherche Scientifique CNRS
Institut National de la Sante et de la Recherche Medicale INSERM
Institut Pasteur
Original Assignee
Centre National de la Recherche Scientifique CNRS
Institut National de la Sante et de la Recherche Medicale INSERM
Institut Pasteur
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR8506707A external-priority patent/FR2581456B1/en
Priority claimed from FR8516820A external-priority patent/FR2589882B2/en
Application filed by Centre National de la Recherche Scientifique CNRS, Institut National de la Sante et de la Recherche Medicale INSERM, Institut Pasteur filed Critical Centre National de la Recherche Scientifique CNRS
Publication of WO1986006494A2 publication Critical patent/WO1986006494A2/en
Publication of WO1986006494A1 publication Critical patent/WO1986006494A1/en
Publication of WO1986006494A3 publication Critical patent/WO1986006494A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4735—Villin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3046—Stomach, Intestines
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Oncology (AREA)
  • Toxicology (AREA)
  • Hospice & Palliative Care (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

The diagnostic in vitro of malignant cells originating from the digestive tube comprises contacting a biological taking with a reactant presenting a specific affinity for villine.
PCT/FR1986/000150 1985-05-02 1986-04-30 Means for in vitro diagnostic of malignant cells originating from the digestive tube Ceased WO1986006494A1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
FR8506707A FR2581456B1 (en) 1985-05-02 1985-05-02 HUMAN VILLINE, AS A MARKER OF PRIMARY MALIGNANT CELLS ORIGINATING IN THE DIGESTIVE TUBE, AND MEANS, IN PARTICULAR ANTIBODIES DIRECTED AGAINST HUMAN VILLINE, FOR THE DETECTION OF SUCH MALIGNANT CELLS
FR85/06707 1985-05-02
FR85/16820 1985-11-13
FR8516820A FR2589882B2 (en) 1985-11-13 1985-11-13 MEANS FOR THE IN VITRO DIAGNOSIS OF MALIGNANT CELLS ORIGINATING IN THE DIGESTIVE TUBE

Publications (3)

Publication Number Publication Date
WO1986006494A2 WO1986006494A2 (en) 1986-11-06
WO1986006494A1 WO1986006494A1 (en) 1986-11-06
WO1986006494A3 true WO1986006494A3 (en) 1987-03-26

Family

ID=

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1984001389A1 (en) * 1982-10-01 1984-04-12 Massachusetts Inst Technology Characterization of oncogenes and assays based thereon

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1984001389A1 (en) * 1982-10-01 1984-04-12 Massachusetts Inst Technology Characterization of oncogenes and assays based thereon

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACTS, Vol. 100, No. 23, 4 Juin 1984 (Columbus, Ohio, US) D.A. AUSIELLE et al.: "Identification of Actin-Binding Protein and Villin in Toad Bladder Epithelia", voir page 348, Ref. 189079e, & AM. J. Physiol. 1984, 246 (1, Pt 2) F101-F104 *
CHEMICAL ABSTRACTS, Vol. 95, No. 13, 28 Septembre 1981 (Columbus, Ohio, US) J.R. GLENNY Jr. et al.: "Demonstration of at Least two Different Actinbinding Sites in Villin, a Calciumregulated Modulator of F-Actin Organization", voir page 249, Ref. 110516s, & J. Biol. Chem. 1981, 256(15), 8156-61 *
CHEMICAL ABSTRACTS, Vol. 98, No. 9, 28 Fevrier 1983 (Columbus, Ohio, US) DRENCKHAHN DETLEV et al.: "Evidence for the Association of Villin with Core Filaments and Rootlets of the Intestinal Epithelial Microvilli", voir page 244, Ref. 67511j, & Cell Tissue Res. 1983, 228(2), 409-14 *
Nature, Vol. 315, No. 6016, Mai 1985 (Londres, GB) P. MATSUDAIRA et al.: "Agelsolinlike Ca2+ Dependent Actinbinding Domain in Villin", pages 248-250, voir le document en entier *
Pascal, 1984, Centre de Documentation Scientifique et Technique du CNRS, (Paris, FR) E. Coudrier et al.: "Expression of two Structural Markers of Brushborder Intestinal Mucosa: Villin and a Membrane Glycoprotein (140KD), in a Human Colon Carcinoma Cell line HT2.", Voir Ref. 84-X-0100064, & J. Submicrosc. Cytol. 1984, 16(1), 159-160 *
Proc. Natl. Acad. Sci. US, Vol. 82, No. 20, Octobre 1985; Biochemistry P. MATSUDAIRA et al.: "Mapping the Cysteine Residues and Actin-Binding Regions of Villin by using Antisera to the Amino and Carboxyl Termini of the Molecule", pages 6788-6792, voir le document en entier *
Proc. Natl. Acad. Sci. US, Vol. 82, No. 24, Decembre 1985, Cell Biology S. ROBINE et al.: "Can Villin be used to Identify Malignant and Undifferentiated Normal Digestive Epithelial Cells? pages 8488-8492, voir le document en entier *
Proc. Natl. Acad. Sci. USA, Vol. 82, No. 20, Octobre 1985; Biochemistry P. MATSUDAIRA et al.: " Mapping the Cysteine Residues and Actin-Binding Regions of Villin by using Antisera to the Amino and Carboxyl Termini of the Molecule", page 6788-6792 voir le document en entier *
Proc. Natl. Acad. Sci. USA, Vol. 82, No. 24, Decembre 1985; Cell Biology S. ROBINE et al.: "Can Villin be used to Identify Malignant and Undifferentiated Normal Digestive Epithelial Cells?", pages 8488-8492, voir le document en entier *

Also Published As

Publication number Publication date
EP0502553B1 (en) 1997-07-30
EP0206849A3 (en) 1987-08-05
DE3650641T2 (en) 1998-03-05
JP2698326B2 (en) 1998-01-19
EP0206849B1 (en) 1993-09-29
JP2698337B2 (en) 1998-01-19
DE3650641D1 (en) 1997-09-04
DE3689084D1 (en) 1993-11-04
EP0206849A2 (en) 1986-12-30
WO1986006494A2 (en) 1986-11-06
JPH07188300A (en) 1995-07-25
EP0502553A3 (en) 1994-05-25
DE3689084T2 (en) 1994-04-28
JPH11123091A (en) 1999-05-11
JPH08208699A (en) 1996-08-13
ATE156136T1 (en) 1997-08-15
JPH1066574A (en) 1998-03-10
EP0502553A2 (en) 1992-09-09

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