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WO1986005695A1 - Nettoyage et/ou desinfection des lentilles de contact - Google Patents

Nettoyage et/ou desinfection des lentilles de contact Download PDF

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Publication number
WO1986005695A1
WO1986005695A1 PCT/GB1986/000168 GB8600168W WO8605695A1 WO 1986005695 A1 WO1986005695 A1 WO 1986005695A1 GB 8600168 W GB8600168 W GB 8600168W WO 8605695 A1 WO8605695 A1 WO 8605695A1
Authority
WO
WIPO (PCT)
Prior art keywords
agent
disinfecting
composition
inactivating
water
Prior art date
Application number
PCT/GB1986/000168
Other languages
English (en)
Inventor
David James Geler Davies
Brian John Meakin
John Elvan Rees
John Nicholas Staniforth
Original Assignee
University Of Bath
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University Of Bath filed Critical University Of Bath
Priority to JP61501825A priority Critical patent/JPH0677597B2/ja
Priority to AT86901961T priority patent/ATE57473T1/de
Priority to BR8607091A priority patent/BR8607091A/pt
Priority to HU863005A priority patent/HU198845B/hu
Priority to DE8686901961T priority patent/DE3675018D1/de
Publication of WO1986005695A1 publication Critical patent/WO1986005695A1/fr
Priority to DK566686A priority patent/DK165818C/da
Priority to FI874192A priority patent/FI85553C/fi

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L12/00—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor
    • A61L12/08—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor using chemical substances
    • A61L12/12—Non-macromolecular oxygen-containing compounds, e.g. hydrogen peroxide or ozone
    • A61L12/124—Hydrogen peroxide; Peroxy compounds

Definitions

  • the present invention relates to the cleaning and/or disinfection of contact lenses and has particular, but not exclusive, application to the cleaning and disinfection of hydrophilic soft contact lenses, for daily and particularly extended wear.
  • Methods and compositions provided by the invention may also be applied to hard contact lenses. It provides disinfecting compositions typically also having a cleansing action and methods of disinfecting contact lenses.
  • Contact lenses are thin convex lenses placed directly on the eye surface to correct sight defects.
  • Hard lenses are made of glass or, more usually, hard plastics, especially cross-linked polymethylmethacrylate.
  • Soft lenses may be made of hydrophobic plastics, especially cross-linked dimethylpolysiloxane, but usually are mad of hydrophilic plastics, especially polyhydroxyethyl- methacrylate cross-linked with hydroxyethyldimethacry- late.
  • the disinfection of hydrophilic soft lenses using chemical agents presents a particular problem in that the lenses can absorb chemical agents from disinfecting solutions in which they are soaked.
  • the most commonly used disinfecting solutions for soft contact lenses are aqueous solutions containing chlorhexidine (or a salt thereof) and it is well established that a sufficiently high concentration of chlorhexidine can build up in the lenses to cause irritation and, some times, damage to the eye of the lens wearer.
  • Extended wear lenses may contain a higher content of carboxyl groups than other soft contact lenses generally. These groups tend to bind chlorhexidine particularly strongly increasing the tendency for these lenses to build up a high concentration of chlorhexidine.
  • hydrogen peroxide is an efficient disinfectant and is particularly attractive in that its decomposition product is simply water.
  • hydrogen peroxide is such a vigorous oxidising agent that it is imperative that it be thoroughly removed from the lenses before they are reinserted in the eye. Failure to do this would be likely to result in severe discomfort and possible damage to the eye.
  • the disadvantages of this process include (a) the necessity of removing the lenses from the hydrogen peroxide solution (which will be effectively sterile because of the presence of the hydrogen peroxide) to a second container which may not be sterile and may indeed contain significant contamination and (b) the danger that the neutralisation step might inadvertently be omitted by a user on some occasion leading to discomfort or eye damage.
  • the danger of significant contamination occurring in the second container is particularly severe ith extended wear lenses because of the lengthy periods of time during which the lenses are worn continuously and the disinfection apparatus is unused.
  • the water or solutions used in the second container are also a potential source of contamination.
  • Other disinfection/cleansing procedures based on peroxides have been proposed. These also suffer from various disadvantages.
  • French Patent Application 2400906 describes a composition for cleaning contact lenses containing an ene diol and a peroxide which are simultaneously added to the lens.
  • the ene diol is intended to reduce the hydrogen peroxide over a period after disinfection has taken place.
  • the presence of the ene diol at the outset of the cleansing procedure means that there is a risk of the peroxide being inactivated before cleansing and disinfection are complete.
  • both ingredients are present intimately mixed in the formulation in dry form, there is a need to ensure that the formulation is not exposed to humidity. Should the formulation become damp, the peroxide will be inactivated. There is therefore a risk of an ineffective cleansing and disinfecting formulation being used, exposing the lens wearer to a risk of infection.
  • European Patent Application 0110609 describes inactivating a hydrogen peroxide solution with pyruvate after cleaning and disinfection of lenses is completed. The danger of the inactivation step being omitted still remains.
  • European Patent Application 0082798 describes a similar approach, suffering from the same disadvantage, but using catalase instead of pyruvate.
  • inactivating agent is provided as a multidose solution problems arise in preserving this solution.
  • Those materials used as preservatives for solutions tend to cause irritation for some lens wearers. Thiomersal, widely used in such solutions is such an example.
  • Other preservative agents as sorbic acid used in such solutions are known to cause unacceptable yellow discoloration of hydrophilic lenses. In the absence of preservatives, there may be a build up of oxidation products or there may be bacterial contamination.
  • composition for disinfecting contact lenses which contains both a disinfecting agent and an inactivating agent which will render the disinfecting agent harmless to the eye after it has successfully disinfected lenses being treated, thus avoiding the danger of the inactivating step being overlooked and avoiding any need to transfer the lenses from the relatively sterile disinfecting agent to a separate container for the removal of the disinfecting agent or its inactivation or to have the inactivator as a conventionally presented multidose solution with the possible danger of introducing oxidative breakdown products of preservatives such as thiomersal or chlorohexidine into the eye or risking hypersensitivity reactions.
  • compositions leave outstanding two problems. First, there remains a risk that the user may remove the lenses from the cleaning and disinfecting solution too soon so that oxidising agent is still present.
  • compositions need to be dissolved in purified water otherwise there may be gradual discoloration of or build up of deposits on the lenses due to the presence of ions such as calcium and magnesium.
  • the present invention provides a contact lens disinfecting composition in solid form for addition to water comprising a contact lens disinfecting agent which is a source of hydrogen peroxide when in water, an inactivating agent capable of rendering the disinfecting agent ophthalmically acceptable, which inactivating agent is in delayed release form, and a colour change indicator such that in use a visible colour change occurs upon inactivation of the disinfecting agent by the inactivating agent.
  • the invention includes a method of disinfecting a contact lens comprising contacting the lens with water and a disinfecting composition of the invention as described herein.
  • the colour change may be from a coloured state to a colourless state.
  • the indicator must be ophthalmically acceptable, at least after the action of the inactivating agent is complete, i.e. after the colour change.
  • the nature of the indicator will depend upon the nature of the disinfecting agent and the inactivating agent. Systems are possible employing acid/base or redox indicators as will be illustrated hereafter.
  • the disinfecting agent releases hydrogen peroxide when in contact with water, which may of course be present as a saline solution or a buffered salt solution.
  • Suitable sources of hydrogen peroxide include inorganic hydroperoxidates, ie salts with hydrogen peroxide of crystallisation. These include percarbonates, eg. sodium percarbonate (Na2C ⁇ 3.1iH2 ⁇ 2) , perpyrophosphates, eg. sodium perpyrophosphate (Na4?2 ⁇ 7. 2H2O2) , and perborates, eg. sodium perborate (NaB ⁇ 2» 2H2O.
  • percarbonates eg. sodium percarbonate (Na2C ⁇ 3.1iH2 ⁇ 2)
  • perpyrophosphates eg. sodium perpyrophosphate (Na4?2 ⁇ 7. 2H2O2)
  • perborates eg. sodium perborate (NaB ⁇ 2» 2H2O.
  • organic hydroperoxidates such as urea peroxide (NH2CONH2. H2O2) , mannitol peroxide (CgH ⁇ O ⁇ * H 2°2 ) > and peroxyacids including those of the general formula R. CO. OOH where R is alkyl, aryl or substituted aryl. Examples include perbenzoic acid and 4 methylperbenzoic acid.
  • hydrogen peroxide yielding compounds include metal peroxides, percarbonates, persulphates, perphosphates, peroxyacids, alkylperoxides, acyl peroxides, peroxyesters and perborates.
  • Percarbonate salts are preferred examples of compounds of this kind.
  • sodium percarbonate is particularly preferred.
  • the percarbonates are particularly preferable because the carbonate component can readily be neutralised by reaction with an acid.
  • Sodium per-pyrophosphate is another preferred compound because the pyrophosphate component can be neutralised in a similar way and because it is also a sequestering agent.
  • compositions according to the invention there is also present an acid to neutralise the carbonate component or phosphate component.
  • the acid is an organic acid and preferably the acid is present in a quantity just sufficient to neutralise the percarbonate or pyrophosphate. 5
  • a pH indicator such as phenolphthalein may be used.
  • Phenolphthalein is advantageous in that it is ophthalmically acceptable and changes from coloured in solutions of hydrogen peroxide and other basic disinfecting agents to colourless in the essentially neutral solutions produced when hydrogen peroxide is reduced by a suitably chosen deactivating agent, such as thiosulphate.
  • the deactivating agent 5 may include an acid to neutralise bases present.
  • a redox indicator which preferably changes from coloured in an oxidised state to colourless when reduced may be used.
  • They include methylene blue and triphenylmethane dyes such as brilliant green and crystal violet.
  • the indicators may be present in very small amounts such as to provide a 0.0001 to 0.1% concentration in the working solution, more preferably about 0.001%.
  • An amount of 0.01 to 1 mg, e.g about 0.1 25 mg may therefore be employed in a unit of compositions according to the invention.
  • the inactivating agent is preferably a sulphurous acid derivative, eg sulphites, bisulphites, and thiosulphate salts such as sodium thiosulphate. More generally, the inactivating agent may be an inorganic sulphur containing reducing agent such as sodium thiosulphate, sodium bisulphite, or sodium metabisulphite, or an unsaturated compound oxidisable by peroxide such as an unsaturated carboxylic acid, eg. ascorbic acid, fumaric acid, maleic acid, pyruvic acid or sorbic acid. Ene-diols as described in French Patent Application No. 2400906 may also be employed.
  • Such acids can also act as a means of pH control as more fully explained hereafter.
  • the amount of inactivating agent present will generally not be critical but will be chosen normally to be sufficient to inactivate all the disinfecting agent provided.
  • the requirements of the inactivating agent are however simply an ability to react with all components of the disinfecting agent which are not ophthalmically acceptable in such a way as to produce products which are ophthalmically acceptable and to be sufficiently ophthalmically acceptable itself that any residual inactivating agent in the solution in which the contact lenses are disinfected will not be unacceptable if the quantity of inactivating agent employed is appropriate.
  • compositions according to the invention preferably contain a sequestering agent capable of sequestering calcium and magnesium ions.
  • the sequestering agent should be used in an amount sufficient to remove calcium and magnesium ions from the water vehicle of a disinfecting solution. Whilst the minimum amount required will vary depending upon the hardess of the water employed, an amount of at least 0.1% by weight usually will be sufficient. Suitably, the amount will be in the range of 0.1 to 1% by weight, usually 0.2 to 0.8% by weight and especially 0.3 to 0.6% by weight.
  • the sequestering agent can be any compound which will sequester at least calcium and/or magnesium ions from water (preferably both calcium and magnesium ions) and which is compatible with the other components and ophthalmic use of a disinfecting solution.
  • the sequestering agent must be non- irritant to the eye at the concentrations used in lens disinfecting solutions.
  • the sequestering agent is a complex polyphosphate, e.g. sodium hexametaphosphate, sodium pyrophosphate, or sodium tripolyphosphate.
  • Alkyldiamine carboxylic acid derivatives may also be used for example the disodium salt of ethylenediaminetetraacetic acid.
  • the compositions according to the invention preferably contain a dechlorinating agent.
  • the dechlorinating agent may be used in an amount which prevents chlorine transference from water chlorination via the lens to the eye.
  • the minimum amount required will vary depending upon the extent of chlorination of the water used but usually 0.001% by weight of the composition will be sufficient.
  • the amount will be in the range of 0.001 to 1% by weight, usually 0.005 to 0.1% by weight, especially about 0.01%.
  • the dechlorinating agent can be any compound which will remove chlorine from water such as tap-water and which is compatible with the other components, and ophthalmic use of the disinfecting solution.
  • the dechlorinating agent must be non-irritant to the eye at the concentrations used in the solution.
  • the dechlorinating agent is a salt of sulphurous acid, eg. sodium metabisulphite, sodium sulphite, sodium bisulphite or, especially, sodium thiosulphate.
  • the sodium thiosulphate can be in the form of its pentahydrate but preferably in its anhydrous form.
  • the inactivating agent will be able to act also as the dechlorinating agent.
  • sodium thiosulphate or other sulphurous acid derivative is the inactivating agent, it will generally not be necessary to provide any other dechlorinating agent. If a separate dechlorinating agent is present which is incompatible with the disinfecting agent in the sense that it will destroy it or interfere with its disinfecting action, as will sodium thiosulphate, then the dechlorinating agent must be in delayed release form, as is the deactivating agent.
  • the composition may contain other components conventionally present in disinfecting solutions for hydrophilic soft contact lenses.
  • it can contain an acid to adjust the pH and/or a tonicity adjusting agent.
  • acids may be present to neutralise sodium percarbonate or other alkaline hydroperoxidates when these are the disinfecting agent.
  • the acid will be present in an amount sufficient to provide the solution with a pH in the range of 4 to 8, preferably 5.5 to 8, especially 6 to 7.5.
  • Suitable acids include pyruvic, ascorbic, sorbic, tartaric, fumaric, citric, maleic, adipic and, preferably, malic acid.
  • the solution can be buffered to the required pH.
  • the acid may also act to inactivate the disinfecting agent.
  • the composition will be chosen such as to produce with an intended volume of water a substantially isotonic solution. If it is necessary to add a component specifically to adjust the tonicity, sodium chloride can be used.
  • the inactivating agent is provided in delayed release form so that after the composition has been added to water, and the contact lens has been added to the mixture, the disinfecting agent will have sufficient time to disinfect the contact lens before release of the inactivating agent in sufficient quantity to halt the disinfecting action occurs.
  • the composition is presented in disinfection unit form such that a single solid disinfection unit of the composition provides an adequate amount of disinfecting agent and inactivating agent for disinfecting a contact lens when added to water (tap, purified, or distilled), saline or buffered salt solution.
  • Suitable unit forms include tablets and capsules, powders, granules and pellets.
  • the neutralising agent in delayed release form may form the core of the tablet and may be surrounded by the disinfecting agent.
  • a tablet capsule, powder, granules or pellets
  • the disinfecting agent and separate particles of the inactivating agent in delayed release form.
  • Delayed release of the inactivating agent may be obtained by coating particles of inactivating agent with a slow dissolving coating material or by including the inactivating agent in a matrix from which it may be slowly leached.
  • the matrix may be coated with a slow dissolving coating so that the start of the slow release is delayed.
  • the delayed release form of the inactivating agent is such that substantially no release occurs during a delay period followed by rapid and substantially complete release of the inactivating agent at the end of the delay period. Such a result may be obtained by coating the inactivating agent with a slow dissolving coating.
  • Materials suitable as retardants include water soluble vinyl polymers such as polyvinylpyrollidone polyvinylalcohol and polyethyleneglycol, water soluble proteins, polysaccharide and cellulose derivatives, eg. methyl cellulose, hydroxypropylmethyl cellulose, sodium carboxy ethylcellulose, alginic acid and its salts and derivatives, and other water soluble naturally occuring gums. Mixtures of the above materials may be used.
  • Such retardant materials may suitably be present at a rate of 1 to 20% of the weight of inactivating substance.
  • sugar based excipients e.g. lactose
  • surfactants e.g. sodium lauryl sulphate
  • polyoxy-ethyleneglycol onoalkyl ethers alkyl-aryl ethoxylates or saccharide esters
  • water soluble polymers such as polyvinylpyrollidone and polyethylene glycol.
  • the disinfecting agent and/or the inactivating agent may be mixed with components providing an effervescent couple to aid dissolution and break up of the formulation.
  • the present invention will be illustrated by the following examples of compositions falling within the scope of the invention.
  • a tablet comprises:- z> * ⁇ _ Sodium percarbonate 40mg
  • Example 2 A tablet comprises:-
  • a tablet comprises:-
  • Example 4 A tablet comprises:-
  • a tablet comprises:- Sodium percarbonate 40mg
  • a tablet comprises:-
  • Example 7 A tablet comprises:-
  • the tablet On dissolution in 10ml of water, the tablet yields a solution containing approximately 0.35% H2O2.
  • the tablet comprises the disinfecting agent tableted with slow release granules of the inactivating agent.
  • Such tablets may be produced by conventional pharmaceutical manufacturing techniques.
  • the inactivating agent in the form of granules may be coated with a solution or suspension of a retardant in an aqueous or organic medium, e.g. by spray granulation with the inactivating agent.
  • the granules of retardant and inactivating agent may then be mixed with the other ingredients together with conventional tableting aids where appropriate and may be compressed using standard machinery.

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  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Apparatus For Disinfection Or Sterilisation (AREA)
  • Eyeglasses (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Detergent Compositions (AREA)

Abstract

Une composition désinfectante pour lentilles de contact sous forme solide et destinée à être additionnée d'eau comprend un agent désinfectant pour lentilles de contact qui devient une source d'eau oxigénée lorsqu'il est additionné d'eau, tel que le percarbonate de sodium, un agent inactivant capable de rendre l'agent désinfectant acceptable pour l'oeil, tel que le thiosulphate de sodium, ledit agent inactivant étant à libération retardée, et un indicateur de changement de couleur de sorte qu'au moment de l'utilisation un changement de couleur visible intervienne lors de l'inactivation de l'agent désinfectant.
PCT/GB1986/000168 1985-03-25 1986-03-24 Nettoyage et/ou desinfection des lentilles de contact WO1986005695A1 (fr)

Priority Applications (7)

Application Number Priority Date Filing Date Title
JP61501825A JPH0677597B2 (ja) 1985-03-25 1986-03-24 コンタクトレンズのための消毒組成物および消毒方法
AT86901961T ATE57473T1 (de) 1985-03-25 1986-03-24 Reinigung und/oder desinfektion von kontaktlinsen.
BR8607091A BR8607091A (pt) 1985-03-25 1986-03-24 Limpeza e/ou desinfeccao de lentes de contato
HU863005A HU198845B (en) 1985-03-25 1986-03-24 Preparation for disinfecting contact lenses
DE8686901961T DE3675018D1 (de) 1985-03-25 1986-03-24 Reinigung und/oder desinfektion von kontaktlinsen.
DK566686A DK165818C (da) 1985-03-25 1986-11-25 Kontaktlinsedesinfektionssammensaetning og fremgangsmaade til desinfektion af en kontaktlinse
FI874192A FI85553C (fi) 1985-03-25 1987-09-24 Sammansaettning och foerfarande foer desinfektion av kontaktlinser.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB858507678A GB8507678D0 (en) 1985-03-25 1985-03-25 Cleaning/disinfection of contact lenses
GB8507678 1985-03-25

Publications (1)

Publication Number Publication Date
WO1986005695A1 true WO1986005695A1 (fr) 1986-10-09

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1986/000168 WO1986005695A1 (fr) 1985-03-25 1986-03-24 Nettoyage et/ou desinfection des lentilles de contact

Country Status (11)

Country Link
US (1) US4863627A (fr)
EP (1) EP0250427B1 (fr)
JP (1) JPH0677597B2 (fr)
AU (1) AU584189B2 (fr)
BR (1) BR8607091A (fr)
DE (1) DE3675018D1 (fr)
DK (1) DK165818C (fr)
FI (1) FI85553C (fr)
GB (2) GB8507678D0 (fr)
HU (1) HU198845B (fr)
WO (1) WO1986005695A1 (fr)

Cited By (33)

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US4767559A (en) * 1987-01-16 1988-08-30 Henkel Kommanditgesellschaft Auf Aktien Process for producing contact lens cleaning tablets with a disinfecting action for one-step cleaning
EP0320980A1 (fr) * 1987-12-18 1989-06-21 Hoya Corporation Utilisation d'un ensemble par la stérilisation de lentilles de contact et méthode de stérilisation de lentilles de contact
US4997626A (en) * 1990-01-05 1991-03-05 Allergan, Inc. Methods to disinfect contact lenses
US5011661A (en) * 1985-07-10 1991-04-30 Ciba-Geigy Corporation Contact lens care set
EP0437179A2 (fr) 1989-12-15 1991-07-17 Ciba-Geigy Ag Nettoyant à pH contrôlé pour enlever des protéines
WO1991012826A1 (fr) * 1990-02-27 1991-09-05 Allergan, Inc. Compositions detruisant le peroxyde d'hydrogene et procedes d'utilisation de cette composition
US5078908A (en) * 1989-10-02 1992-01-07 Allergan, Inc. Methods for generating chlorine dioxide and compositions for disinfecting
WO1992004922A1 (fr) * 1990-09-25 1992-04-02 Allergan, Inc. Appareil et procede de desinfection d'une lentille de contact et de detection de la presence d'un desinfectant oxydant
WO1992004921A1 (fr) * 1990-09-25 1992-04-02 Allergan, Inc. Appareil et procede de desinfection d'une lentille de contact et de detection de la presence d'un desinfectant oxydant
WO1992011042A1 (fr) * 1990-12-19 1992-07-09 Allergan, Inc. Compositions et procedes de desinfection de lentilles de contact
US5129999A (en) * 1990-10-04 1992-07-14 Allergan, Inc. Lens disinfector and method
US5145644A (en) * 1990-12-20 1992-09-08 Allergan, Inc. Hydrogen peroxide destroying compositions and methods of making and using same
US5152912A (en) * 1990-01-05 1992-10-06 Allergan, Inc. Chlorine dioxide precursor containing compositions useful in disinfecting contact lenses
US5169455A (en) * 1991-10-04 1992-12-08 Kessler Jack H Method for simultaneously cleaning and disinfecting contact lenses
US5197636A (en) * 1992-02-03 1993-03-30 Allergan, Inc. Fast activation chlorine dioxide delivery apparatus
US5246662A (en) * 1989-10-02 1993-09-21 Allergan, Inc. Methods for generating chlorine dioxide and compositions for disinfecting
US5270002A (en) * 1991-10-03 1993-12-14 Allergan, Inc. Apparatus and method useful in disinfecting contact lenses
US5279673A (en) * 1990-01-05 1994-01-18 Allergan, Inc. Methods to disinfect contact lenses
US5312588A (en) * 1990-02-27 1994-05-17 Allergan, Inc. Hydrogen peroxide destroying compositions and methods of making and using same
US5320806A (en) * 1990-01-05 1994-06-14 Allegan, Inc. Methods to disinfect contact lenses
US5324447A (en) * 1989-10-02 1994-06-28 Allergan, Inc. Method and activator compositions to disinfect lenses
US5336434A (en) * 1989-10-02 1994-08-09 Allergan, Inc. Methods, compositions and apparatus to disinfect lenses
US5338480A (en) * 1989-10-02 1994-08-16 Allegan, Inc. Compositions and methods to clean contact lenses
WO1995013097A1 (fr) * 1993-11-10 1995-05-18 Allergan, Inc. Compositions et procedes permettant d'empecher et de reduire la formation de depot de lysozyme sur des verres de contact hydrophiles, a l'aide de composes colores biocompatibles
US5424078A (en) * 1988-11-29 1995-06-13 Allergan, Inc. Aqueous ophthalmic formulations and methods for preserving same
US5447650A (en) * 1993-10-06 1995-09-05 Allergan, Inc. Composition for preventing the accumulation of inorganic deposits on contact lenses
US5491091A (en) * 1989-08-01 1996-02-13 Schering Corporation Contact lens disinfecting system
US5523012A (en) * 1991-07-19 1996-06-04 Ciba-Geigy Corporation Hydrogen peroxide disinfection solutions
US5576276A (en) * 1989-12-15 1996-11-19 Ciba Geigy Corp. Method of cleaning ophthalmic lenses with alkaline composition
US5703024A (en) * 1995-06-30 1997-12-30 Allergan Compositions and methods for disinfecting a contact lens and detecting the presence of an oxidative disinfectant
US5736165A (en) * 1993-05-25 1998-04-07 Allergan In-the-eye use of chlorine dioxide-containing compositions
US6099800A (en) * 1998-08-14 2000-08-08 Sinphar Pharmaceutical Co., Ltd. Process for cleaning and disinfecting contact lens and hydrogen peroxide destroying composition having a delayed release function for use therein
US9205608B2 (en) 2011-12-31 2015-12-08 Novartis Ag Contact lenses with identifying mark

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GB2189045B (en) * 1986-03-22 1990-11-28 Smith & Nephew Ass Disinfecting contact lenses using sulphur dioxide.
JP2840301B2 (ja) * 1989-07-07 1998-12-24 トーメー産業株式会社 着色コンタクトレンズに付着したタンパク質汚れの除去方法及びそのための洗浄剤
US5306352A (en) * 1989-12-28 1994-04-26 Ciba-Geigy Corporation Peroxide disinfection method
ZA913506B (en) * 1990-05-22 1992-02-26 Alcon Lab Inc Double redox system for disinfecting contact lenses
GB9012790D0 (en) * 1990-06-08 1990-08-01 Interox Chemicals Ltd Food storage
US5180517A (en) * 1990-11-05 1993-01-19 United States Borax & Chemical Corporation Stabilized liquid persalt bleach compositions
IT1243946B (it) * 1990-11-29 1994-06-28 Zeiss Carl Spa Metodo per la disinfezione e la detersione di lenti a contatto.
US5209783A (en) * 1990-12-21 1993-05-11 Allergan, Inc. Method for simultaneously cleaning, decolorizing and thermally disinfecting contact lenses
NZ243749A (en) * 1991-08-30 1994-11-25 Allergan Inc Composition for neutralising and indicating the absence of peroxide comprising a neutralising compound and vitamin b-12
EP0542686A1 (fr) * 1991-11-13 1993-05-19 Ciba-Geigy Ag Méthode et récipient pour la stérilisation et la désinfection
US5719100A (en) * 1992-03-20 1998-02-17 Zahradnik; Rudolf Water treatment compositions
AU677638B2 (en) 1993-01-26 1997-05-01 Allergan, Inc. Compositions and methods to disinfect contact lenses
US5648074A (en) * 1993-05-25 1997-07-15 Allergan Compositions and methods for disinfecting contact lenses and reducing proteinaceous deposit formation
US5494817A (en) * 1993-12-06 1996-02-27 Allergan, Inc. Sugar-based protease composition for use with constant-PH borate buffers
US5603897A (en) * 1994-06-30 1997-02-18 Bausch & Lomb Incorporated Method for indicating neutralization of contact lens disinfecting solutions
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JPS62502245A (ja) 1987-09-03
FI85553C (fi) 1992-05-11
FI874192L (fi) 1987-09-24
GB8507678D0 (en) 1985-05-01
GB2173017A (en) 1986-10-01
AU5662786A (en) 1986-10-23
GB8607243D0 (en) 1986-04-30
EP0250427B1 (fr) 1990-10-17
US4863627A (en) 1989-09-05
HU198845B (en) 1989-12-28
DK566686A (da) 1986-11-25
FI874192A0 (fi) 1987-09-24
DK165818B (da) 1993-01-25
BR8607091A (pt) 1988-01-19
GB2173017B (en) 1988-11-02
DK566686D0 (da) 1986-11-25
JPH0677597B2 (ja) 1994-10-05
AU584189B2 (en) 1989-05-18
HUT46239A (en) 1988-10-28
DK165818C (da) 1993-06-21
FI85553B (fi) 1992-01-31
EP0250427A1 (fr) 1988-01-07
DE3675018D1 (de) 1990-11-22

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