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WO1986004234A3 - Antagonistes de la thromboxane dans le traitement des neoplasias dependant des hormones - Google Patents

Antagonistes de la thromboxane dans le traitement des neoplasias dependant des hormones

Info

Publication number
WO1986004234A3
WO1986004234A3 PCT/GB1986/000028 GB8600028W WO8604234A3 WO 1986004234 A3 WO1986004234 A3 WO 1986004234A3 GB 8600028 W GB8600028 W GB 8600028W WO 8604234 A3 WO8604234 A3 WO 8604234A3
Authority
WO
WIPO (PCT)
Prior art keywords
group
oxygen
aliphatic hydrocarbon
groups
sulphur atom
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/GB1986/000028
Other languages
English (en)
Other versions
WO1986004234A2 (fr
Inventor
Judith Senior
Kay Marie Troughton
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
National Research Development Corp UK
Original Assignee
National Research Development Corp UK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by National Research Development Corp UK filed Critical National Research Development Corp UK
Priority to AT86900799T priority Critical patent/ATE52689T1/de
Priority to DE8686900799T priority patent/DE3671167D1/de
Publication of WO1986004234A2 publication Critical patent/WO1986004234A2/fr
Publication of WO1986004234A3 publication Critical patent/WO1986004234A3/fr
Priority to DK442186A priority patent/DK442186A/da
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/005—Analogues or derivatives having the five membered ring replaced by other rings
    • C07C405/0075—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system
    • C07C405/0091—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system which is bridged condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
    • A61K31/175—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine having the group, >N—C(O)—N=N— or, e.g. carbonohydrazides, carbazones, semicarbazides, semicarbazones; Thioanalogues thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Des composés ayant une activité antagoniste de la thromboxane sont utiles dans le traitement des néoplasias dépendant des hormones, par exemple les néoplasias dépendant des oestrogènes. Des antagonistes de la thromboxane particulièrement indiqués sont des composés de formule (I) où la formule (II) représente un des groupes cycliques bivalents (III), les lettres a et b indiquant dans chaque cas les points de fixation des substituants R1 et CV(R2)-NV'R, respectivement R1 est un groupe 6-carboxyhex-2-enyl ou une modification de celui-ci dans laquelle le groupe est modifié par un, ou une combinaison appropriée de deux ou plus, des facteurs suivants: a) modification de la position de la double liaison, b) réduction de cette dernière, c) modification de la longueur de la chaîne par le biais d'une diminution d'un ou deux groupes méthylène ou d'une augmentation d'un à six groupes méthylène, d) remplacement d'un ou deux groupes méthylène chacun séparément par un atome d'oxygène ou de soufre à condition que dans le groupe modifié, aucun atome d'oxygène ou de soufre ne soit dans une position alpha par rapport soit à un atome de carbone à liaison double soit au groupe carboxy ou un de ses dérivés, et qu'au moins deux atomes de carbone séparent toute paire d'atomes d'oxygène et/ou de soufre; et e) formation d'un amide, ester ou dérivé de sel du groupe carboxy; V et V' chacun séparément sont de l'hydrogène, ou ensemble sont la seconde liaison d'une liaison double carbone-azote; R2 est de l'hydrogène, un groupe d'hydrocarbures aliphatiques ou un groupe d'hydrocarbures aliphatiques substitués par un groupe aromatique directement ou par l'intermédiaire d'un atome d'oxygène ou de soufre; et R est un groupe -NH.CO.NH-R3 ou -NH.CS.NH-R3 où R3 est un groupe d'hydrocarbures aliphatiques, un groupe aromatique ou bien un groupe d'hydrocarbures aliphatiques substitués par un ou plusieurs groupes aromatiques directement ou par l'intermédiaire d'un atome d'oxygène ou de soufre.
PCT/GB1986/000028 1985-01-16 1986-01-16 Antagonistes de la thromboxane dans le traitement des neoplasias dependant des hormones Ceased WO1986004234A2 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AT86900799T ATE52689T1 (de) 1985-01-16 1986-01-16 Thromboxan-antagonisten in der behandlung von hormonbedingten neoplasmen.
DE8686900799T DE3671167D1 (de) 1985-01-16 1986-01-16 Thromboxan-antagonisten in der behandlung von hormonbedingten neoplasmen.
DK442186A DK442186A (da) 1985-01-16 1986-09-15 Thromboxan antagonister i forbindelse med behandlingen af hormonafhaengig neoplasi

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB858501035A GB8501035D0 (en) 1985-01-16 1985-01-16 Prostaglandins
GB8501035 1985-01-16

Publications (2)

Publication Number Publication Date
WO1986004234A2 WO1986004234A2 (fr) 1986-07-31
WO1986004234A3 true WO1986004234A3 (fr) 1986-09-12

Family

ID=10572919

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1986/000028 Ceased WO1986004234A2 (fr) 1985-01-16 1986-01-16 Antagonistes de la thromboxane dans le traitement des neoplasias dependant des hormones

Country Status (11)

Country Link
US (1) US4902717A (fr)
EP (2) EP0208755B1 (fr)
JP (1) JPS62501500A (fr)
AU (1) AU594660B2 (fr)
CA (1) CA1269936A (fr)
DE (1) DE3671167D1 (fr)
DK (1) DK442186A (fr)
GB (2) GB8501035D0 (fr)
IE (1) IE860132L (fr)
WO (1) WO1986004234A2 (fr)
ZA (1) ZA86333B (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8600997D0 (en) * 1986-01-16 1986-02-19 Jones R L Prostaglandin synthesis
NZ218881A (en) * 1986-01-16 1989-05-29 Nat Res Dev Prostaglandin derivatives and analogues as pharmaceuticals
GB2218311B (en) * 1986-01-16 1990-02-28 Nat Res Dev Prostagladin intermediates
US5077309A (en) * 1986-01-16 1991-12-31 National Research Development Corporation Prostaglandins
US5166201A (en) * 1990-11-30 1992-11-24 Merrell Dow Pharmaceuticals Inc. 2β,19-ethylene bridged steroids as aromatase inhibitors
WO2002098420A1 (fr) * 2001-06-01 2002-12-12 Cytovia, Inc. 4-substitute-1-(arylmethylidene)thiosemicarbazide, 4-substitue-1-(arylcarbonyl)thiosemicarbazide et analogues en tant qu'activateurs de capsases et declencheurs d'apoptose, et leur utilisation
GB0125492D0 (en) * 2001-10-24 2001-12-12 Astrazeneca Ab Formulation
WO2013124029A2 (fr) * 2012-02-22 2013-08-29 Merck Patent Gmbh Polymères contenant des unités structurales sous forme de dibenzocycloheptane

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0013608A1 (fr) * 1979-01-05 1980-07-23 National Research Development Corporation Bicyclo (2,2,1)heptanes et hept-2-ènes substitués et leurs compositions pharmaceutiques
EP0043292A2 (fr) * 1980-07-01 1982-01-06 National Research Development Corporation Prostaglandines
EP0094792A1 (fr) * 1982-05-17 1983-11-23 E.R. Squibb &amp; Sons, Inc. Analogues de prostaglandine 7-oxabicycloheptane amino substitués
EP0107995A1 (fr) * 1982-10-25 1984-05-09 E.R. Squibb &amp; Sons, Inc. Analogues de prostaglandine 7-oxabicycloheptane amino substitués

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2854128C3 (de) * 1978-12-15 1982-02-18 Licentia Patent-Verwaltungs-Gmbh, 6000 Frankfurt Empfängerschaltung mit Verbesserung des Signal-Rauschabstandes
GB2039480B (en) * 1979-01-05 1983-06-15 Jones R Prostaglandins
EP0045118B1 (fr) * 1979-01-05 1984-04-04 National Research Development Corporation Intermédiaires pour la synthèse de bicyclo (2,2,1) heptanes et bicyclo (2,2,1) hept-2Z-ènes
AU561739B2 (en) * 1981-12-23 1987-05-14 British Technology Group Limited Prostaglandins
US4418076A (en) * 1982-05-03 1983-11-29 E. R. Squibb & Sons, Inc. 7-Oxabicycloheptane hydrazone prostaglandin analogs useful in treating thrombolytic diseases
US4536510A (en) * 1983-07-22 1985-08-20 Smith Kline Beckman Corporation Method of antagonizing the effects of thromboxane
US4673685A (en) * 1986-07-23 1987-06-16 E. R. Squibb & Sons, Inc. Hydroximic acids of 7-oxabicycloheptane substituted ethers and thioethers useful in the treatment of thrombotic disease

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0013608A1 (fr) * 1979-01-05 1980-07-23 National Research Development Corporation Bicyclo (2,2,1)heptanes et hept-2-ènes substitués et leurs compositions pharmaceutiques
EP0043292A2 (fr) * 1980-07-01 1982-01-06 National Research Development Corporation Prostaglandines
EP0111955A1 (fr) * 1980-07-01 1984-06-27 National Research Development Corporation Intermédiaires de prostaglandines
EP0094792A1 (fr) * 1982-05-17 1983-11-23 E.R. Squibb &amp; Sons, Inc. Analogues de prostaglandine 7-oxabicycloheptane amino substitués
EP0107995A1 (fr) * 1982-10-25 1984-05-09 E.R. Squibb &amp; Sons, Inc. Analogues de prostaglandine 7-oxabicycloheptane amino substitués

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
Biochemical and Biophysical Research Communications, Vol. 102, No. 4, 30 October 1981 K.V. HONN et al.: "Thromboxanes and Prostacyclin: Positive and Negative Modulators of Tumor Growth", pages 1122-1129, see page 1122, three bottom lines; page 1123, "Materials and Methods", entry 5. Compounds; page 1125, text; page 1126, first three lines; page 1127; page 1128, lines 1,2 *
Br. J. Cancer, Vol. 48, 1983 D.L. McCORMICK et al.: "Inhibition of *
Gynecologic Oncology, Vol. 16, Academic Press, Inc., 1983; O. YLIKORKALA et al.: "Prostacyclin and Thromboxane in Ovarian Cancer: Effect of Cystostatics and Prostaglandin Synthesis Inhibitors", pages 340-345, see the entire document *
J. Cell Biol., Vol. 87, Nr. 2II, 1980 see page 64, entry No. CI442 K.V. HONN et al.: "Thromboxane Synthetase Inhibitors and Prostacyclin can Control Tumor Cell Metastasis", see the entire document *

Also Published As

Publication number Publication date
DK442186D0 (da) 1986-09-15
GB2169803A (en) 1986-07-23
AU5317486A (en) 1986-08-13
EP0336522A3 (fr) 1990-03-21
DK442186A (da) 1986-11-17
GB8601017D0 (en) 1986-02-19
GB8501035D0 (en) 1985-02-20
ZA86333B (en) 1987-09-30
CA1269936A (fr) 1990-06-05
GB2169803B (en) 1989-08-31
EP0208755B1 (fr) 1990-05-16
EP0336522A2 (fr) 1989-10-11
EP0208755A1 (fr) 1987-01-21
DE3671167D1 (de) 1990-06-21
US4902717A (en) 1990-02-20
WO1986004234A2 (fr) 1986-07-31
IE860132L (en) 1986-07-16
AU594660B2 (en) 1990-03-15
JPS62501500A (ja) 1987-06-18

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