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WO1986003394A1 - Dispositif d'echantillonnage de liquides - Google Patents

Dispositif d'echantillonnage de liquides Download PDF

Info

Publication number
WO1986003394A1
WO1986003394A1 PCT/GB1985/000576 GB8500576W WO8603394A1 WO 1986003394 A1 WO1986003394 A1 WO 1986003394A1 GB 8500576 W GB8500576 W GB 8500576W WO 8603394 A1 WO8603394 A1 WO 8603394A1
Authority
WO
WIPO (PCT)
Prior art keywords
container
tube
inlet tube
capillary tube
funnel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/GB1985/000576
Other languages
English (en)
Inventor
John Patrick Kavanagh
Charles Howe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Manchester
Original Assignee
Victoria University of Manchester
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Victoria University of Manchester filed Critical Victoria University of Manchester
Publication of WO1986003394A1 publication Critical patent/WO1986003394A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Instruments for taking body samples for diagnostic purposes; Other methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determination; Throat striking implements
    • A61B10/0045—Devices for taking samples of body liquids
    • A61B10/007—Devices for taking samples of body liquids for taking urine samples
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/20—Measuring for diagnostic purposes; Identification of persons for measuring urological functions restricted to the evaluation of the urinary system

Definitions

  • THIS INVENTION concerns a device for collecting a predetermined sample from a stream of liquid. More particularly, the device is intended for the separation of an initial 10ml or so of urine from the remainder of a sample thereof.
  • VBl the first 10ml of a sample
  • VB2 the first 10ml of a sample
  • VB3 the first 10ml of a sample passed shortly after a prostatic massage has been performed.
  • Samples VBl and VB3 represent urethral washings, the latter being expected to contain a representative sample of prostatic fluid.
  • the volume collected should be reproducible from patient to patient.
  • a recent technique is to measure the zinc content of sample VB3, since this gives an indication as to the secretory activity of the prostate.
  • Samples are conventionally obtained using a marked container and instructing a patient to cease urinating when the liquid level reaches the mark. This is found to be neither accurate nor reproducible, particularly in the collection of sample VB3.
  • An object of the present invention is to provide a device which will automatically separate the first lOmls of a urine sample from that which follows, without any patient intervention. It will be preferable also for the device to be sufficiently inexpensive in manufacture, to be made available as a disposable item.
  • a device for separating a predetermined initial volume of a liquid sample comprising a container, an air ⁇ tight closure member for the container, an open-ended inlet tube passing through said closure member for introducing liquid into the container and a capillary tube also passing through the closure member and open-ended to permit displacement of air therefrom, the end of the capillary tube within the container being disposed above the base thereof at a higher level than that of the inlet tube and at a predetermined distance from the base such that filling of the container, via said inlet tube, above the end of the capillary tube i s substantially prevented, whereby to enable a predetermined volume of liquid to be collected.
  • the requirement of the device is the separation of the f irst 10ml or so of urine from the remainder of the sample.
  • the actual volume is not of crit ical importance, but the reproducibility is.
  • the device comprises a chamber 10 in the form of a sterile disposable polystyrene bottle, having, say, 30ml capacity.
  • the bottle has a closure member 11 which is adapted to produce an air-tight seal thereon.
  • a funnel 12 or like receptacle is connected to an inlet tube 13 , pre ferably of a rigid or semi-r igid material, and having an internal diameter of 5mm to 6mm, which passes through the air-tight closure member 11 and is terminated some di stance above the base of the container 10.
  • an inlet tube 13 preferably of a rigid or semi-r igid material, and having an internal diameter of 5mm to 6mm, which passes through the air-tight closure member 11 and is terminated some di stance above the base of the container 10.
  • a shut-off valve 15 preferably of a type capable of one- handed operation (push to close, push and release to open) .
  • a capillary tube 16 having an internal diameter in the region of 1mm to 2mm also passes through closure member 11, is open-ended and is connected via a further tube 17 of similar diameter to the interior of funnel 12.
  • the lower end of capillary tube 16 within container 10 is disposed at such a height above the base of the latter that the intervening volume is just less than 10ml for a purpose to be described.
  • the lower end of inlet tube 13 is disposed below that of tube 16.
  • a container 10 may be provided with a supplementary air-tight closure cap (not shown) which can be applied after removal of the closure member 11 and tubes 13 and 16, or alternatively, the member 11 may be left in situ.
  • a supplementary air-tight closure cap (not shown) which can be applied after removal of the closure member 11 and tubes 13 and 16, or alternatively, the member 11 may be left in situ.
  • a patient is instructed to urinate into the collecting funnel 12 until the liquid level has reached approximately half way up the funnel.
  • the initial urine representing sample VBl flows directly into the container 10 until the liquid level rises to the lower end of capillary tube 16 whereupon further displacement of air through the tube 16 is prevented which in turn substantially prevents further entry of urine into the container.
  • the capillary tube offers substantial resistance to the liquid attempting to rise therein, and the maximum level to which liquid can, in any case, rise in the tubes 16 and 17 is equivalent to the level of liquid in the funnel 12. Even at this level the volume of liquid in the tubes 16 and 17 is negligible for the purpose of the sample.
  • valve 15 is closed and the assembly, with or without tubes 13 and 16, is removed from the container which then may be sealed for subsequent analysis of the sample. Liquid remaining in funnel 12 is disposed of.
  • the capillary tube 16 may be adjustably located in closure member 11 and have graduated markings to enable the volume of the sample to be regulated.
  • the assembly comprising all but the container 10 in the drawing, may be provided, pre-assembled, in a sterile package, and inserted for use into a standard container after removal of its closure cap, and the said assembly may be disposed of after use.
  • the assembly will be made entirely from plastics in order to minimise the cost of manufacture.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Surgery (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Physiology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Dispositif de séparation d'un volume initial prédéterminé d'un liquide en écoulement, tel que de l'urine pendant la miction, comprenant un récipient (10), un organe de fermeture (11) recevant un tube d'admission (13) relié à un entonnoir (12), et un tube capillaire (16) relié via un autre tube (17) avec l'intérieur de l'entonnoir (12). Une vanne d'arrêt (15) agit sur un segment de tube flexible (14). L'échantillon de liquide se déverse à travers l'entonnoir (12) et le tube d'admission (13) dans un récipient (10) jusqu'à ce que le niveau atteigne le fond du tube capillaire (16); à partir de ce moment le liquide ne pénètre pratiquement plus dans le récipient (10). La vanne d'arrêt (15) est fermée alors pour empêcher que le liquide continue à s'écouler à travers le tube d'admission (13). On collecte ainsi un volume initial connu de liquide déterminé par la hauteur du tube capillaire (16).
PCT/GB1985/000576 1984-12-12 1985-12-12 Dispositif d'echantillonnage de liquides Ceased WO1986003394A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB848431388A GB8431388D0 (en) 1984-12-12 1984-12-12 Liquid sampling device
GB8431388 1984-12-12

Publications (1)

Publication Number Publication Date
WO1986003394A1 true WO1986003394A1 (fr) 1986-06-19

Family

ID=10571081

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1985/000576 Ceased WO1986003394A1 (fr) 1984-12-12 1985-12-12 Dispositif d'echantillonnage de liquides

Country Status (3)

Country Link
EP (1) EP0243360A1 (fr)
GB (1) GB8431388D0 (fr)
WO (1) WO1986003394A1 (fr)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990013280A1 (fr) * 1989-04-28 1990-11-15 Uroshield Pty. Limited Urinal de prise du flux central
GB2276568A (en) * 1993-03-22 1994-10-05 Marvin Adelberg Medical body fluid sampler device and method
WO2004010873A1 (fr) * 2002-07-26 2004-02-05 Diagnostics For The Real World, Ltd Echantillonneur de liquide et procede
CN108287089A (zh) * 2018-01-17 2018-07-17 卡斯纳（苏州）医疗设备有限公司 一种检验科用尿液收集器
CN109187088A (zh) * 2018-11-07 2019-01-11 青海盐湖工业股份有限公司 一种在线液体取样器
US11197659B2 (en) 2013-03-04 2021-12-14 Forte Medical Limited Urine collection device

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB128834A (en) * 1918-11-18 1919-07-03 Leon Broche Improvements in Apparatus for Delivering Measured Quantities of Liquids.
CH304674A (de) * 1952-09-01 1955-01-31 Obrist Jakob Fülleinrichtung zur Abgabe abgemessener Mengen in Behälter.
US3420107A (en) * 1965-07-16 1969-01-07 Lancelot R Rowett Disposable urine specimen tube
GB2098487A (en) * 1981-05-18 1982-11-24 Sta Te Srl Device for collecting and holding urine

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB128834A (en) * 1918-11-18 1919-07-03 Leon Broche Improvements in Apparatus for Delivering Measured Quantities of Liquids.
CH304674A (de) * 1952-09-01 1955-01-31 Obrist Jakob Fülleinrichtung zur Abgabe abgemessener Mengen in Behälter.
US3420107A (en) * 1965-07-16 1969-01-07 Lancelot R Rowett Disposable urine specimen tube
GB2098487A (en) * 1981-05-18 1982-11-24 Sta Te Srl Device for collecting and holding urine

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990013280A1 (fr) * 1989-04-28 1990-11-15 Uroshield Pty. Limited Urinal de prise du flux central
GB2276568A (en) * 1993-03-22 1994-10-05 Marvin Adelberg Medical body fluid sampler device and method
GB2276568B (en) * 1993-03-22 1997-04-02 Marvin Adelberg Medical body fluid sampling container
WO2004010873A1 (fr) * 2002-07-26 2004-02-05 Diagnostics For The Real World, Ltd Echantillonneur de liquide et procede
US7547298B2 (en) 2002-07-26 2009-06-16 Diagnostics For The Real World, Ltd. Liquid sampler and method
US11197659B2 (en) 2013-03-04 2021-12-14 Forte Medical Limited Urine collection device
CN108287089A (zh) * 2018-01-17 2018-07-17 卡斯纳（苏州）医疗设备有限公司 一种检验科用尿液收集器
CN109187088A (zh) * 2018-11-07 2019-01-11 青海盐湖工业股份有限公司 一种在线液体取样器

Also Published As

Publication number Publication date
GB8431388D0 (en) 1985-01-23
EP0243360A1 (fr) 1987-11-04

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