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WO1986000224A1 - Agent de soins cutanes et son procede de fabrication - Google Patents

Agent de soins cutanes et son procede de fabrication Download PDF

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Publication number
WO1986000224A1
WO1986000224A1 PCT/HU1985/000037 HU8500037W WO8600224A1 WO 1986000224 A1 WO1986000224 A1 WO 1986000224A1 HU 8500037 W HU8500037 W HU 8500037W WO 8600224 A1 WO8600224 A1 WO 8600224A1
Authority
WO
WIPO (PCT)
Prior art keywords
mass
blood plasma
skin care
plasma extract
weight
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/HU1985/000037
Other languages
German (de)
English (en)
Inventor
István LACZKÓ
Eszter KOVÁCS
Erzsébet BASA
Jánosné CSELOVSKY
Péter BANETH
Miklósné GÁBOR
Lászlóné FÜLÖP
Györgyné VARRÓ
Béla HORVÁTH
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Elelmiszeripari Fo^"iskola
Universal Vegyipari Szovetkezet
Original Assignee
Elelmiszeripari Fo^"iskola
Universal Vegyipari Szovetkezet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Elelmiszeripari Fo^"iskola, Universal Vegyipari Szovetkezet filed Critical Elelmiszeripari Fo^"iskola
Publication of WO1986000224A1 publication Critical patent/WO1986000224A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/004—Aftersun preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0212—Face masks
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
    • A61K8/981—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of mammals or bird
    • A61K8/983—Blood, e.g. plasma
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q1/00—Make-up preparations; Body powders; Preparations for removing make-up
    • A61Q1/02—Preparations containing skin colorants, e.g. pigments
    • A61Q1/10—Preparations containing skin colorants, e.g. pigments for eyes, e.g. eyeliner, mascara
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/10—Washing or bathing preparations

Definitions

  • the invention relates to a skin care product which can be used in the different areas of skin care together with the known carrier, additive, fragrance, preservative and optionally protective and coloring agents which are customary for this.
  • the skin care product according to the invention can therefore be used as a bath product, i.e. as a cream bath, shower bath (gel), body care milk, also in the form of creams, i.e. as a face cream, night cream, face pack (mask), also as sunscreen such as sun milk, sunscreen foam, after-sun cream and also as lip gloss or eyeshadow, but numerous other manifestations are conceivable in addition to the forms listed here.
  • the different skin care products have the non-secondary task of nourishing and protecting the skin, restoring its elasticity and giving it its natural condition. This is the main purpose for cream products, and a complementary function for bathing products or sunscreens.
  • human skin has a protective film which is in the form of a suspension or an emulsion.
  • This protective film has a pH of 4.5-5.5, and is therefore also called the protective acid mantle of the skin. It consists of sebum, water, various amino acids, proteins and minerals. When cleaning the skin, this protective coat can be damaged and dry out, so it must be returned to its natural state.
  • the preparations produced to nourish the skin, to preserve or restore its natural state contain, as active ingredients, extracts of vegetable or animal origin, which are rich in proteins and amino acids and therefore exert an advantageous influence on the skin.
  • the object of the invention is to meet this real need satisfy and accordingly to create a novel skin care product and a process for its preparation.
  • the invention is based on the knowledge that, among the natural active ingredients, all those that make it possible to achieve the stated goal are contained in the blood due to its protein and amino acid composition.
  • the use of the hat in its natural form for cosmetic purposes is hampered by numerous circumstances, including its tendency to clot and spoil, its color, etc.
  • the industrial use of blood from slaughterhouses is well known. It is treated with an anticoagulator and then separated into thick blood and blood plasma in the separator.
  • the blood plasma is mainly used in the food industry. It mainly contains globulins, lipoproteins and fibrinogen as protein groups. In its natural form, the blood plasma seems unsuitable for use as an active ingredient due to its high water content and its perishability.
  • a blood plasma extract which can be used according to the invention as an active ingredient for skin care products can be obtained from blood plasma by drying.
  • the blood plasma extract contains a relatively large amount of salt, since the salt concentration increases with drying and concentration as the water emerges.
  • the composition of the blood plasma, the dried blood plasma and the content of essential amino acids in the blood plasma are given below (Grant, R.A .: Applied protein chemistry, Applied Sei. Publishers, Ltd., London, 1980).
  • the protein content of the dried blood plasma is therefore 71.9% and that of the blood plasma is only 7.9%. This almost tenfold amount results from the considerable reduction in the water content.
  • the 16.5% salt contained in the dried blood plasma is an obstacle for most cosmetic applications, primarily the salts originating from the anticoagulator pose a danger. These are different phosphates that coagulate the proteins on the surface of the skin.
  • the high salt content has a dehydrating effect, dries out the skin and can also irritate it.
  • the blood plasma extract can therefore only be used in small quantities for cosmetic purposes. The thickening of the blood plasma, however, cannot be done only by drying.
  • ultrafiltration With the technology referred to in the industry as ultrafiltration, particles with a molecular weight of only 16000-18000 can be separated from the liquid phase.
  • the molar mass of the valuable proteins and amino acids contained in the blood plasma is above this range, and they can therefore be separated from the liquid phase by ultrafiltration.
  • Ultrafiltration not only removes the liquid, but also the salts dissolved in it, ie the extract has a much lower salt content.
  • the blood plasma thickened by ultrafiltration only has a salt content of about 4.1%, of which only about 2.5% are residues originating from the anticoagulator. This amount of salt can already be described as negligible.
  • the invention relates to a skin care product which can be used in different areas of skin care and which contains carriers, additives, fragrances and other substances which are characteristic of these areas.
  • the skin care agent according to the invention contains, as an active ingredient, blood plasma extract obtained from slaughterhouse blood in an amount of at least 0.3% by mass and at most 6% by mass.
  • the advantages of the protein components contained in the blood plasma also compensate for the possible disadvantages of the salt content contained in the dried blood plasma extract.
  • Much more favorable results are achieved, however, if the salt concentration in the blood plasma extract is at most 6%, in particular below 4.2%. This concentration can only be achieved by ultrafiltration. If the blood plasma extract is not broken down into fractions, it retains its original composition and the residues from the anticoagulant added to the slaughterhouse blood account for a maximum of 60% of the permissible salt content.
  • the protein and amino acid composition of the blood plasma extract corresponds to that of the blood plasma and the protein concentration in the extract is at least 60%.
  • serum albumin and serum globulins in particular have the property of adding water tie; they are adsorbed on the skin surface and protect the skin from drying out, have a hydrating effect.
  • the gamma globulin which can only be found in the blood plasma, is known to be the antidote to acute diseases, it increases the resistance of the organism.
  • the lipoproteins are suitable for the stabilization of water / oil systems and their presence in the skin care products which represent emulsion systems has a stabilizing effect.
  • the lipoproteins also contain fat on their surface, so they supplement the fat content of the skin.
  • the amino acid composition of the fibrinogen contained in the plasma is more favorable compared to that of other biologically active compounds (collagen, elastin).
  • the threonine content of the fibrinogen is three and six times as high, and the leucine and isoleucine content is about three times that of the collagen.
  • Fibrinogen contains five times as much tyrosine and more than twice as much lysine as collagen, and its lysine content is sixteen times that of elastin.
  • the arginine content of the blood plasma is six times that of the elastin. Tryptophan is not found at all in collagen and elastin, but in significant amounts in fibrinogen.
  • Collagen contains no cystine, and elastin contains only one seventh of the cystine content of fibrinogen.
  • the other important sulfur-containing amino acid, methionine is only present in trace amounts in elastin, and collagen also contains only a quarter of the methionine content of fibrinogen.
  • Collagen and elastin are considered to be extremely advantageous as active ingredients in skin care products.
  • the comparative figures given therefore show some of the advantages that result from the use of blood plasma.
  • Example 1 Two phases are prepared for the production of a cream bath. The first consists of sodium lauryl ether sulfate at 50% by mass, 1% by mass of fragrances and 1% by mass of refatting agent, the second from 42.5% by mass of distilled water, 3% by mass of sodium chloride and 3% by mass of blood plasma extract. The two phases are stirred separately until everything has dissolved, and then the first phase is dissolved in the second phase.
  • Example 2 Two phases are prepared for the production of a cream bath. The first consists of sodium lauryl ether sulfate at 50% by mass, 1% by mass of fragrances and 1% by mass of refatting agent, the second from 42.5% by mass of distilled water, 3% by mass of sodium chloride and 3% by mass of blood plasma extract. The two phases are stirred separately until everything has dissolved, and then the first phase is dissolved in the second phase.
  • Example 2
  • a shower bath has the following composition: 40% by weight of surface-active substance, preferably sodium lauryl ether sulfate, 20% by weight of betaine derivative, 5% by weight of fatty acid diethanolamide, 0.5% by weight of fragrances, 0.5% by weight of preservative, 2% by weight of blood plasma extract and 32% by weight Water.
  • surface-active substance preferably sodium lauryl ether sulfate, 20% by weight of betaine derivative, 5% by weight of fatty acid diethanolamide, 0.5% by weight of fragrances, 0.5% by weight of preservative, 2% by weight of blood plasma extract and 32% by weight Water.
  • the first phase contains 6 mass% emulsifier, 3 mass% isopropyl myristate, 8 mass% paraffin oil, 0.5 mass% cetyl alcohol and 2 mass% light protection substance against UV radiation.
  • the second phase contains 1 mass% of water-soluble lipid-replenishing agent, 1 mass% of blood plasma extract, 0.4 mass% of propylene glycol and 5 mass% of preservative as well as 73.1 mass% of distilled water.
  • the blood plasma extract is swollen in water, then the components of the second phase are added. Both phases are heated separately to 70-75 ° C, then the first phase is added to the second phase with vigorous stirring. With slow stirring, the mixture is cooled to 30-35 ° C. and fragrance is added in an amount of 0.2% by mass.
  • Example 4 Sun protection foam is also produced from two phases.
  • the first phase contains 10 mass% emulsifier, 2.5 mass% fat phase component, and the second phase contains 70.7 mass% distilled water, 1 mass% blood plasma extract, 5 mass% propylene glycol and 0.3 mass% preservative.
  • the bluplasma extract is first swelled in water and then the other components of the second phase are added.
  • the two phases are heated separately to about 75 ° C.
  • the first phase is poured into the second and the system is emulsified. It is stirred more slowly and at a temperature of about 40 ° C 0.5% by weight of fragrances are added. 85% of the mass obtained are filled together with 15% propellant gas in spray containers.
  • the first phase consists of 15% by mass of ethyl alcohol, 0.5% by mass of fragrances and 3.5% by mass of refatting agent and the second phase consists of 67% by mass of distilled water, 1% by weight of D-panthenol and 1% by mass % Blood plasma extract, 2 mass% hydrating additives, 5 mass% of an extract pulling the pores together and 5 mass% chamomile distillate.
  • the phases are mixed and homogenized.
  • Example 6 Personal care milk is also prepared in two phases.
  • the first phase consists of 7.5 mass% emulsifier and 45 mass% paraffin oil
  • the second phase consists of 46.75 mass% distilled water and 0.5 mass% blood plasma extract.
  • the two phases are heated separately to 70 ° C and an emulsion is prepared by pouring the second phase into the first. With slow stirring, the mixture is cooled back to 30-35 ° C. and then fragrance is added in an amount of 0.25% by mass.
  • Example 7
  • the first phase contains 25 mass% emulsifier, 5 mass% isopropyl myristate and 8 mass% paraffin oil and the second phase 48.5 mass% distilled water, 5.5 mass5 propylene glycol, 2 mass% hydrating additives, 0.5 mass% magnesium sulfate and 5 Mass% blood plasma extract.
  • the phases are heated separately to 70 ° C, then the second phase is poured into the first with rapid stirring and the mixture is cooled to about 35 ° C with slow stirring. At this temperature, 0.5% by mass of fragrances are added.
  • a face pack is prepared according to the following recipe: 6 mass% stearin, 0.3 mass% triethanolamine, 5 mass% bleach, 0.5 mass% blood plasma extract, 71.2 mass% water, 15 mass% kaolin and 2 mass% Titanium dioxide.
  • the blood plasma extract and the bleach are dissolved in part of the water with stirring.
  • the stearin is melted at 75 ° C and added together with the mixture of the remaining water with the triethanolamine with vigorous stirring at 80 ° C.
  • the mixture is cooled to 35 ° C. with stirring, and kaolin and titanium dioxide are added at this temperature.
  • a face pack is prepared according to the following recipe: 5 mass% fat phase component, 5 mass% 86% glycerol, 23 mass% 96% ethyl alcohol, 2 mass5 blood plasma extract, 0.1 mass% triethanolamine, 0.2 mass% fragrance and 64.7 Mass% consistency. In the latter, the blood plasma extract is dissolved and the other substances are added.
  • a face cream is prepared in two phases.
  • the first phase contains 16 mass% fat phase component and 13 mass% emulsifier, while the second phase consists of 5 mass% 1,2-propylene glycol, 61 mass% water and 5 mass% blood plasma extract.
  • the pH of the aqueous phase is adjusted to 3.7-6.5. Both phases are heated to 75-80 ° C and then mixed together.
  • Example 11 From 30% by mass of lanolin, 51% by mass of polybutene, 4% by mass
  • Paraffin wax, 9% by mass of dye, 5% by mass of blood plasma extract and 1% by mass of flavoring agents is used to produce lip gloss by melting the materials at 80-90 ° C, homogenizing them and then filling them into cans at 50-60 ° C.
  • Eye shadow is prepared from two phases.
  • the first contains 10% by mass of stearic acid. 10 mass% iron oxide, 3.3 mass% isopropyl myristate, 0.2 mass% preservative and 2 mass% emulsifier
  • the second consists of 3.3 mass% triethanolamine, 10 mass% magnesium aluminum silicate, 7.5 mass% film former, 2.5 Mass% 1,2-propanediol, 0.2 mass% preservative, the rest is ion-free water.
  • Both phases are heated to about 75 ° C, then the aqueous phase is emulsified in the fat phase with slow stirring. 5% by mass of dye and 1% by mass of blood plasma extract are added to the cream obtained.
  • the blood plasma extract means the desalted extract produced by ultrafiltration. All of the products described had an excellent effect and proved the existence of the advantages already explained in practice.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dermatology (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Zoology (AREA)
  • Cosmetics (AREA)

Abstract

Agent de soins cutanés pouvant être utilisé dans les différents domaines des soins cutanés avec les substances connues habituelles, comme les supports, les additifs, les parfums, les agents de conservation et le cas échéant les agents protecteurs et les colorants. Cet agent de soins cutanés peut se présenter comme produit pour le bain, c'est-à-dire comme crème pour le bain, gel de bain-douche, lait pour le corps, sous forme de crèmes, c'est-à-dire en tant que crème pour le visage, crème de nuit, masque pour le visage, en outre comme agent de protection solaire par exemple lait solaire, mousse de protection solaire, lotion après-soleil, ainsi que rouge à lèvres ou ombre à paupière; outre toutes les formes mentionnées ici, il reste pourtant possible de trouver de nombreuses autres applications. Cet agent de soins cutanés contient en tant que substance active de l'extrait de plasma sanguin provenant de sang d'abattoir dans une quantité d'au moins 0,3 et d'au plus 6% en poids. Pour préparer cet agent de soins cutanés, on trempe l'extrait de plasma sanguin, avantageusement de l'extrait de plasma sanguin obtenu par ultrafiltration avec une faible teneur en sel, dans de l'eau ou une émulsion avant de le mélanger à l'état trempé avec les autres composants.
PCT/HU1985/000037 1984-06-19 1985-06-19 Agent de soins cutanes et son procede de fabrication Ceased WO1986000224A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU234884A HU193290B (en) 1984-06-19 1984-06-19 Cinditioning cosmetical composition containing blood plasma concentrate as active agent
HU2348/84 1984-06-19

Publications (1)

Publication Number Publication Date
WO1986000224A1 true WO1986000224A1 (fr) 1986-01-16

Family

ID=10958953

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/HU1985/000037 Ceased WO1986000224A1 (fr) 1984-06-19 1985-06-19 Agent de soins cutanes et son procede de fabrication

Country Status (3)

Country Link
EP (1) EP0186681A1 (fr)
HU (1) HU193290B (fr)
WO (1) WO1986000224A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1283032A1 (fr) * 2001-08-10 2003-02-12 JOHNSON & JOHNSON CONSUMER COMPANIES, INC. Composition pour le soin cutané qui change de couleur lors du séchage

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1467952B (de) * Ikapharm Anstalt f. pharmazeutische und kosmetische Produkte, Schaan (Liechtenstein) Verwendung von oberflächenaktiven Substanzen zur Stabilisierung von kosmetischen Zubereitungen
FR431904A (fr) * 1911-05-09 1911-11-23 Schaefer De Esparza Caroline Procédé de préparation de solutions d'albumine pour usages cosmétiques, sans addition d'autres matières
GB1038415A (en) * 1964-04-17 1966-08-10 Curtis Helene Ind Inc Cosmetic preparations containing albumins
DE2237271A1 (de) * 1971-07-29 1973-02-08 Oreal Verfahren zur konservierung und konditionierung von kosmetischen mitteln, sowie mittel, die durch dieses verfahren konserviert sind
FR2160285A1 (en) * 1971-11-17 1973-06-29 Metzinger Albert Embryonic serum-based compsn - used as a skin tonic
DE2310533A1 (de) * 1972-03-03 1973-09-06 Jean D Albret S A Substanz mit verjuengender eigenschaft und diese substanz verwendendes kosmetisches erzeugnis
FR2472385A1 (fr) * 1979-12-27 1981-07-03 Sederma Sa Nouveaux extraits biologiques utilisables en cosmetologie, et procedes d'obtention de ces extraits

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1467952B (de) * Ikapharm Anstalt f. pharmazeutische und kosmetische Produkte, Schaan (Liechtenstein) Verwendung von oberflächenaktiven Substanzen zur Stabilisierung von kosmetischen Zubereitungen
FR431904A (fr) * 1911-05-09 1911-11-23 Schaefer De Esparza Caroline Procédé de préparation de solutions d'albumine pour usages cosmétiques, sans addition d'autres matières
GB1038415A (en) * 1964-04-17 1966-08-10 Curtis Helene Ind Inc Cosmetic preparations containing albumins
DE2237271A1 (de) * 1971-07-29 1973-02-08 Oreal Verfahren zur konservierung und konditionierung von kosmetischen mitteln, sowie mittel, die durch dieses verfahren konserviert sind
FR2160285A1 (en) * 1971-11-17 1973-06-29 Metzinger Albert Embryonic serum-based compsn - used as a skin tonic
DE2310533A1 (de) * 1972-03-03 1973-09-06 Jean D Albret S A Substanz mit verjuengender eigenschaft und diese substanz verwendendes kosmetisches erzeugnis
FR2472385A1 (fr) * 1979-12-27 1981-07-03 Sederma Sa Nouveaux extraits biologiques utilisables en cosmetologie, et procedes d'obtention de ces extraits

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Keine Entgegenhaltungen. *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1283032A1 (fr) * 2001-08-10 2003-02-12 JOHNSON & JOHNSON CONSUMER COMPANIES, INC. Composition pour le soin cutané qui change de couleur lors du séchage

Also Published As

Publication number Publication date
HU193290B (en) 1987-09-28
EP0186681A1 (fr) 1986-07-09

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