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UY36544A - Derivados de 4h-pirrol[3,2-c]piridin-4-ona - Google Patents

Derivados de 4h-pirrol[3,2-c]piridin-4-ona

Info

Publication number
UY36544A
UY36544A UY0001036544A UY36544A UY36544A UY 36544 A UY36544 A UY 36544A UY 0001036544 A UY0001036544 A UY 0001036544A UY 36544 A UY36544 A UY 36544A UY 36544 A UY36544 A UY 36544A
Authority
UY
Uruguay
Prior art keywords
pirrol
piridin
ona
derivatives
drugs
Prior art date
Application number
UY0001036544A
Other languages
English (en)
Inventor
Dr Jozsef Bálint
René Tempel
Dr Hans Briem
Dr Volker Schulze
Dr Gerhard Siemeister
Dr Philip Lienau
Dr Ulrich Klar
Dr Keith Graham
Original Assignee
Bayer Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Pharma AG filed Critical Bayer Pharma AG
Publication of UY36544A publication Critical patent/UY36544A/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/45Non condensed piperidines, e.g. piperocaine having oxo groups directly attached to the heterocyclic ring, e.g. cycloheximide
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/08Vasodilators for multiple indications
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D519/00Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Compuestos de la fórmula I procesos para su producción y su uso como fármacos.
UY0001036544A 2015-01-28 2016-01-28 Derivados de 4h-pirrol[3,2-c]piridin-4-ona UY36544A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP15152944 2015-01-28
EP15200407 2015-12-16

Publications (1)

Publication Number Publication Date
UY36544A true UY36544A (es) 2016-08-31

Family

ID=55236350

Family Applications (1)

Application Number Title Priority Date Filing Date
UY0001036544A UY36544A (es) 2015-01-28 2016-01-28 Derivados de 4h-pirrol[3,2-c]piridin-4-ona

Country Status (30)

Country Link
US (1) US10428063B2 (es)
EP (1) EP3250567B1 (es)
JP (1) JP6704398B2 (es)
KR (1) KR102544847B1 (es)
CN (1) CN107406417B (es)
AU (1) AU2016212230B2 (es)
BR (1) BR112017016193B1 (es)
CA (1) CA2974853C (es)
CL (1) CL2017001930A1 (es)
CO (1) CO2017007663A2 (es)
CR (1) CR20170345A (es)
CU (1) CU20170094A7 (es)
DO (1) DOP2017000176A (es)
EA (1) EA032530B1 (es)
EC (1) ECSP17048527A (es)
IL (1) IL253284B (es)
JO (1) JO3706B1 (es)
MX (1) MX380239B (es)
MY (1) MY182181A (es)
NI (1) NI201700096A (es)
PE (1) PE20171240A1 (es)
PH (1) PH12017501340A1 (es)
SG (1) SG11201705908VA (es)
SV (1) SV2017005487A (es)
TN (1) TN2017000329A1 (es)
TW (1) TWI699359B (es)
UA (1) UA122221C2 (es)
UY (1) UY36544A (es)
WO (1) WO2016120196A1 (es)
ZA (1) ZA201705802B (es)

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TWI808055B (zh) 2016-05-11 2023-07-11 美商滬亞生物國際有限公司 Hdac 抑制劑與 pd-1 抑制劑之組合治療
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Also Published As

Publication number Publication date
PH12017501340A1 (en) 2017-12-18
ECSP17048527A (es) 2017-10-31
EA032530B1 (ru) 2019-06-28
CA2974853A1 (en) 2016-08-04
ZA201705802B (en) 2019-07-31
CR20170345A (es) 2017-09-29
CN107406417B (zh) 2020-06-09
WO2016120196A1 (en) 2016-08-04
DOP2017000176A (es) 2017-08-31
US20180016272A1 (en) 2018-01-18
SG11201705908VA (en) 2017-08-30
MX380239B (es) 2025-03-12
MX2017009831A (es) 2017-11-02
CL2017001930A1 (es) 2018-03-09
MY182181A (en) 2021-01-18
IL253284B (en) 2020-08-31
BR112017016193B1 (pt) 2023-02-23
TWI699359B (zh) 2020-07-21
PE20171240A1 (es) 2017-08-24
HK1244804A1 (zh) 2018-08-17
KR102544847B1 (ko) 2023-06-16
JP6704398B2 (ja) 2020-06-03
IL253284A0 (en) 2017-09-28
CO2017007663A2 (es) 2017-10-10
EP3250567A1 (en) 2017-12-06
CN107406417A (zh) 2017-11-28
JP2018503648A (ja) 2018-02-08
AU2016212230B2 (en) 2019-09-19
CU20170094A7 (es) 2017-12-08
KR20170106452A (ko) 2017-09-20
US10428063B2 (en) 2019-10-01
NI201700096A (es) 2017-10-24
AU2016212230A1 (en) 2017-07-20
CA2974853C (en) 2023-02-21
JO3706B1 (ar) 2021-01-31
SV2017005487A (es) 2019-01-17
BR112017016193A2 (pt) 2018-04-17
UA122221C2 (uk) 2020-10-12
EP3250567B1 (en) 2019-10-30
EA201791692A1 (ru) 2018-01-31
TN2017000329A1 (en) 2019-01-16
TW201639828A (zh) 2016-11-16

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