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UY35399A - Conjugados de fármacos con anticuerpos - Google Patents

Conjugados de fármacos con anticuerpos

Info

Publication number
UY35399A
UY35399A UY0001035399A UY35399A UY35399A UY 35399 A UY35399 A UY 35399A UY 0001035399 A UY0001035399 A UY 0001035399A UY 35399 A UY35399 A UY 35399A UY 35399 A UY35399 A UY 35399A
Authority
UY
Uruguay
Prior art keywords
antibodies
conjugates
drugs
fgfr2
cancer
Prior art date
Application number
UY0001035399A
Other languages
English (en)
Inventor
Ettenberg Seth
Haubst Nicole
David Bryant Batt
Hu Tiancen
Jenkins David
Toksoz Engin
Petropoulos Konstantin
Mosher Rebecca
Matthew John Meyer
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of UY35399A publication Critical patent/UY35399A/es

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    • C07—ORGANIC CHEMISTRY
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
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    • A61K47/6879—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody being a hybrid immunoglobulin the immunoglobulin having two or more different antigen-binding sites, e.g. bispecific or multispecific immunoglobulin
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    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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    • C07—ORGANIC CHEMISTRY
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • C07K16/3023—Lung
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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  • Urology & Nephrology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
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  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
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Abstract

La presente invención se relaciona con anticuerpos anti-FGFR2 y FGFR4, fragmentos de anticuerpos, c onjugados de fármacos con anticuerpos, y sus usos para el tratamiento del cáncer.
UY0001035399A 2013-03-13 2014-03-12 Conjugados de fármacos con anticuerpos UY35399A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201361780299P 2013-03-13 2013-03-13

Publications (1)

Publication Number Publication Date
UY35399A true UY35399A (es) 2014-10-31

Family

ID=50897870

Family Applications (1)

Application Number Title Priority Date Filing Date
UY0001035399A UY35399A (es) 2013-03-13 2014-03-12 Conjugados de fármacos con anticuerpos

Country Status (14)

Country Link
US (2) US9498532B2 (es)
EP (1) EP2968592A2 (es)
JP (2) JP2016518332A (es)
KR (1) KR20150130333A (es)
CN (1) CN105188763B (es)
AR (1) AR096015A1 (es)
AU (2) AU2014244060B2 (es)
BR (1) BR112015023418A8 (es)
CA (1) CA2904090A1 (es)
EA (1) EA201591611A1 (es)
MX (1) MX2015012122A (es)
TW (1) TW201444574A (es)
UY (1) UY35399A (es)
WO (1) WO2014160160A2 (es)

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TWI669313B (zh) 2012-04-09 2019-08-21 第一三共股份有限公司 抗ＦＧＦＲ２抗體及其製造方法、及檢測或測定人類ＦＧＦＲ２ＩＩＩｂ之方法
UA125503C2 (uk) 2012-06-13 2022-04-13 Інсайт Холдинґс Корпорейшн Заміщені трициклічні сполуки як інгібітори fgfr
US9388185B2 (en) 2012-08-10 2016-07-12 Incyte Holdings Corporation Substituted pyrrolo[2,3-b]pyrazines as FGFR inhibitors
US9266892B2 (en) 2012-12-19 2016-02-23 Incyte Holdings Corporation Fused pyrazoles as FGFR inhibitors
US9415118B2 (en) 2013-03-13 2016-08-16 Novartis Ag Antibody drug conjugates
MY181497A (en) 2013-04-19 2020-12-23 Incyte Holdings Corp Bicyclic heterocycles as fgfr inhibitors
ME03476B (me) 2013-08-01 2020-01-20 Five Prime Therapeutics Inc Nefukozilisana anti-fgfr2iiib antitijela
TWI541022B (zh) * 2013-12-18 2016-07-11 應克隆公司 針對纖維母細胞生長因子受體－３（ｆｇｆｒ３）之化合物及治療方法
WO2015109391A1 (en) 2014-01-24 2015-07-30 Children's Hospital Of Eastern Ontario Research Institute Inc. Smc combination therapy for the treatment of cancer
JOP20200094A1 (ar) 2014-01-24 2017-06-16 Dana Farber Cancer Inst Inc جزيئات جسم مضاد لـ pd-1 واستخداماتها
JOP20200096A1 (ar) 2014-01-31 2017-06-16 Children’S Medical Center Corp جزيئات جسم مضاد لـ tim-3 واستخداماتها
CA2936962C (en) 2014-03-14 2024-03-05 Novartis Ag Antibody molecules to lag-3 and uses thereof
MA41044A (fr) 2014-10-08 2017-08-15 Novartis Ag Compositions et procédés d'utilisation pour une réponse immunitaire accrue et traitement contre le cancer
CA2964367C (en) 2014-10-14 2024-01-30 Novartis Ag Antibody molecules to pd-l1 and uses thereof
US10851105B2 (en) 2014-10-22 2020-12-01 Incyte Corporation Bicyclic heterocycles as FGFR4 inhibitors
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AU2014244060B2 (en) 2017-04-20
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US20170106095A1 (en) 2017-04-20
WO2014160160A3 (en) 2015-01-08
US20140301946A1 (en) 2014-10-09
MX2015012122A (es) 2016-11-08
CN105188763A (zh) 2015-12-23
WO2014160160A2 (en) 2014-10-02
AU2014244060A1 (en) 2015-10-01
US9498532B2 (en) 2016-11-22
AU2017202150B2 (en) 2018-12-20
CA2904090A1 (en) 2014-10-02
CN105188763B (zh) 2019-02-19
BR112015023418A8 (pt) 2018-01-23
BR112015023418A2 (pt) 2017-11-28
AR096015A1 (es) 2015-12-02
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AU2017202150A1 (en) 2017-04-20
KR20150130333A (ko) 2015-11-23
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