UY35697A - FC BI-SPECIFIC MONOVALENT SPECIFICS THAT ARE ABLE TO JOIN CD32B AND CD79B AND USES OF MY SMOS - Google Patents
FC BI-SPECIFIC MONOVALENT SPECIFICS THAT ARE ABLE TO JOIN CD32B AND CD79B AND USES OF MY SMOSInfo
- Publication number
- UY35697A UY35697A UY35697A UY35697A UY35697A UY 35697 A UY35697 A UY 35697A UY 35697 A UY35697 A UY 35697A UY 35697 A UY35697 A UY 35697A UY 35697 A UY35697 A UY 35697A
- Authority
- UY
- Uruguay
- Prior art keywords
- cd32b
- specific
- cd79b
- monovalent
- diabodies
- Prior art date
Links
- 101000917824 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor II-b Proteins 0.000 title abstract 4
- 102100029205 Low affinity immunoglobulin gamma Fc region receptor II-b Human genes 0.000 title abstract 4
- 102100027203 B-cell antigen receptor complex-associated protein beta chain Human genes 0.000 title 1
- 101000914491 Homo sapiens B-cell antigen receptor complex-associated protein beta chain Proteins 0.000 title 1
- 230000009870 specific binding Effects 0.000 abstract 2
- 201000000596 systemic lupus erythematosus Diseases 0.000 abstract 2
- 108060003951 Immunoglobulin Proteins 0.000 abstract 1
- 230000027455 binding Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 102000018358 immunoglobulin Human genes 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
Landscapes
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La presente invención está dirigida a diacuerpos monovalentes bi-específicos que compren den un dominio Fc de inmunoglobulina (?diacuerpos de Fc monovalentes b i-específicos?) y están compuestos de tres cadenas de polipéptido y que poseen por lo menos un sitio de unión específico para un epítopo de CD32B y un sitio de unión específico para un epítopo de CD7 9b (es decir , un ?diacuerpo de Fc monovalente bi-específico CD32B x CD79b?). Los diacuerpos de Fc monovalentes bi-específicos de la presente invención son capaces de la unión simultánea a CD32B y CD79b. La invención está dirigida a dichas composiciones, a composiciones farmacéuticas que contienen dichos diacuerpos de Fc monovalentes bi-específicos y a métodos para su uso en el tratamiento de enfermedades o condiciones inflamatorias, y en particular, lupus eritematoso sistémico (SLE) y enfermedad de injerto contra huésped.The present invention is directed to bi-specific monovalent diabodies that purchase an immunoglobulin Fc domain (? Bi-specific monovalent Fc diabodies?) And are composed of three polypeptide chains and possess at least one specific binding site for a CD32B epitope and a specific binding site for a CD7 9b epitope (ie, a? monovalent bi-specific CD32B x CD79b? diabody). The bi-specific monovalent Fc diabodies of the present invention are capable of simultaneous binding to CD32B and CD79b. The invention is directed to said compositions, to pharmaceutical compositions containing said bi-specific monovalent Fc diabodies and to methods for use in the treatment of inflammatory diseases or conditions, and in particular, systemic lupus erythematosus (SLE) and graft disease against Guest.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201313618642A | 2013-08-09 | 2013-08-09 | |
| US201361866416P | 2013-08-15 | 2013-08-15 | |
| US201361869519P | 2013-08-23 | 2013-08-23 | |
| US201361907525P | 2013-11-22 | 2013-11-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UY35697A true UY35697A (en) | 2015-02-27 |
Family
ID=52705343
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UY35697A UY35697A (en) | 2013-08-09 | 2014-08-06 | FC BI-SPECIFIC MONOVALENT SPECIFICS THAT ARE ABLE TO JOIN CD32B AND CD79B AND USES OF MY SMOS |
Country Status (1)
| Country | Link |
|---|---|
| UY (1) | UY35697A (en) |
-
2014
- 2014-08-06 UY UY35697A patent/UY35697A/en unknown
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