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UY35483A - Anticuerpos pac1 humanos - Google Patents

Anticuerpos pac1 humanos

Info

Publication number
UY35483A
UY35483A UY35483A UY35483A UY35483A UY 35483 A UY35483 A UY 35483A UY 35483 A UY35483 A UY 35483A UY 35483 A UY35483 A UY 35483A UY 35483 A UY35483 A UY 35483A
Authority
UY
Uruguay
Prior art keywords
pac1
antibodies
human antibodies
binding fragments
antigen
Prior art date
Application number
UY35483A
Other languages
English (en)
Inventor
Xu Cen
Hamburger Agnes Eva
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of UY35483A publication Critical patent/UY35483A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2869—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against hormone receptors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Endocrinology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pain & Pain Management (AREA)
  • Public Health (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

Anticuerpos y fragmentos de unión al antígeno de los mismos que se unen a la PAC1 humana. También se proveen ácidos nucleicos que codifican los anticuerpos y los fragmentos de unión al antígeno de los mismos, vectores y células que los codifican. Los anticuerpos y los fragmento de unión al antígeno de los mismos pueden inhibir la unión de PAC1 a PACAP, y son de utilidad en numerosos trastornos relacionados con PAC1, incluyendo el tratamiento y/o la prevención de trastornos de cefalea, inclusive la migraña.
UY35483A 2013-03-15 2014-03-17 Anticuerpos pac1 humanos UY35483A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201361792678P 2013-03-15 2013-03-15

Publications (1)

Publication Number Publication Date
UY35483A true UY35483A (es) 2014-08-29

Family

ID=50439531

Family Applications (1)

Application Number Title Priority Date Filing Date
UY35483A UY35483A (es) 2013-03-15 2014-03-17 Anticuerpos pac1 humanos

Country Status (24)

Country Link
US (7) US9676851B2 (es)
EP (2) EP2970470B1 (es)
JP (3) JP6283408B2 (es)
KR (1) KR102215405B1 (es)
CN (1) CN105143267B (es)
AP (1) AP2015008732A0 (es)
AR (1) AR095611A1 (es)
AU (2) AU2014228924B2 (es)
CA (1) CA2906737C (es)
CL (1) CL2015002750A1 (es)
CR (1) CR20150575A (es)
EA (1) EA032830B1 (es)
ES (1) ES2770976T3 (es)
HK (2) HK1219958A1 (es)
IL (2) IL241382A0 (es)
MA (1) MA38478A1 (es)
MX (1) MX378292B (es)
PE (1) PE20151923A1 (es)
PH (1) PH12015502126A1 (es)
SG (1) SG11201507416WA (es)
TN (1) TN2015000425A1 (es)
TW (2) TW201902931A (es)
UY (1) UY35483A (es)
WO (1) WO2014144632A2 (es)

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EP3194435A1 (en) * 2014-09-15 2017-07-26 Amgen Inc. Bi-specific anti-cgrp receptor/pac1 receptor antigen binding proteins and uses thereof

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EA039859B1 (ru) * 2015-07-31 2022-03-21 Эмджен Рисерч (Мюник) Гмбх Биспецифические конструкты антител, связывающие egfrviii и cd3
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AR113022A1 (es) * 2017-09-29 2020-01-15 Lilly Co Eli Anticuerpo anti-pacap
CN111164101B (zh) * 2017-10-04 2025-04-25 安进公司 甲状腺素视黄质运载蛋白免疫球蛋白融合体
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CN118271444A (zh) 2017-12-19 2024-07-02 瑟罗泽恩奥普瑞汀公司 Wnt替代分子和其用途
AR114080A1 (es) 2018-01-12 2020-07-22 Amgen Inc Anticuerpos pac1 y sus usos
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JP7756001B2 (ja) 2019-06-28 2025-10-17 アムジエン・インコーポレーテツド 抗ｃｇｒｐ受容体／抗ｐａｃ１受容体二重特異性抗原結合タンパク質
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EP4380970A1 (en) * 2021-08-06 2024-06-12 Amgen Inc. Isolation of therapeutic protein
CN117916259A (zh) * 2021-09-30 2024-04-19 江苏恒瑞医药股份有限公司 特异性结合cgrp和pacap的抗原结合分子及其医药用途
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Publication number Priority date Publication date Assignee Title
EP3194435A1 (en) * 2014-09-15 2017-07-26 Amgen Inc. Bi-specific anti-cgrp receptor/pac1 receptor antigen binding proteins and uses thereof

Also Published As

Publication number Publication date
AP2015008732A0 (en) 2015-09-30
US10793631B2 (en) 2020-10-06
TN2015000425A1 (en) 2017-01-03
CA2906737A1 (en) 2014-09-18
CL2015002750A1 (es) 2016-03-04
EA032830B1 (ru) 2019-07-31
CR20150575A (es) 2016-01-06
CA2906737C (en) 2023-08-15
EA201591791A1 (ru) 2016-03-31
WO2014144632A8 (en) 2015-12-30
PH12015502126A1 (en) 2016-01-25
BR112015023429A8 (pt) 2018-01-23
TW201902931A (zh) 2019-01-16
JP2016514458A (ja) 2016-05-23
US20180094055A1 (en) 2018-04-05
US9676851B2 (en) 2017-06-13
CN105143267A (zh) 2015-12-09
IL241382A0 (en) 2015-11-30
EP2970470B1 (en) 2019-12-04
JP6283408B2 (ja) 2018-02-21
US10053507B2 (en) 2018-08-21
US20150010560A1 (en) 2015-01-08
AU2014228924B2 (en) 2019-04-18
AU2014228924A1 (en) 2015-10-01
US20180362645A1 (en) 2018-12-20
TW201522375A (zh) 2015-06-16
KR102215405B1 (ko) 2021-02-10
AR095611A1 (es) 2015-10-28
JP6443870B2 (ja) 2018-12-26
CN105143267B (zh) 2020-06-26
IL262804A (en) 2018-12-31
KR20150128982A (ko) 2015-11-18
HK1219958A1 (zh) 2017-04-21
US9365653B2 (en) 2016-06-14
WO2014144632A3 (en) 2014-11-20
HK1218554A1 (zh) 2017-02-24
PE20151923A1 (es) 2016-01-14
US20170247451A1 (en) 2017-08-31
US20200172614A1 (en) 2020-06-04
WO2014144632A2 (en) 2014-09-18
US9822178B2 (en) 2017-11-21
MX378292B (es) 2025-03-10
MX2015013181A (es) 2015-12-11
EP3683237A1 (en) 2020-07-22
US20160251432A1 (en) 2016-09-01
EP2970470A2 (en) 2016-01-20
JP2018076373A (ja) 2018-05-17
JP2019024501A (ja) 2019-02-21
MA38478A1 (fr) 2017-11-30
BR112015023429A2 (pt) 2017-11-28
ES2770976T3 (es) 2020-07-06
US10294298B2 (en) 2019-05-21
SG11201507416WA (en) 2015-10-29
US10472417B2 (en) 2019-11-12
AU2014228924A9 (en) 2016-06-16
US20160039939A1 (en) 2016-02-11
AU2019204980A1 (en) 2019-08-01
TWI636064B (zh) 2018-09-21

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