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UY30444A1 - PIRIMIDINE DERIVATIVES, PROCESSES FOR PREPARATION, PHARMACCUTIC COMPOSITIONS AND USES OF THE SAME. - Google Patents

PIRIMIDINE DERIVATIVES, PROCESSES FOR PREPARATION, PHARMACCUTIC COMPOSITIONS AND USES OF THE SAME.

Info

Publication number
UY30444A1
UY30444A1 UY30444A UY30444A UY30444A1 UY 30444 A1 UY30444 A1 UY 30444A1 UY 30444 A UY30444 A UY 30444A UY 30444 A UY30444 A UY 30444A UY 30444 A1 UY30444 A1 UY 30444A1
Authority
UY
Uruguay
Prior art keywords
pharmaccutic
compositions
processes
preparation
same
Prior art date
Application number
UY30444A
Other languages
Spanish (es)
Inventor
David Buttar
David Rudge
Kevin Michael Foote
Thorsten Nowak
Theoclitou Marie-Elena
Thomas Andrew Peter
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of UY30444A1 publication Critical patent/UY30444A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

Se proporciona un compuesto de formula (I): proceso para la fabricacion del mismo, composiciones farmacéuticas del mismo y usos en terapias.A compound of formula (I) is provided: process for the manufacture thereof, pharmaceutical compositions thereof and uses in therapies.

UY30444A 2006-06-30 2007-06-27 PIRIMIDINE DERIVATIVES, PROCESSES FOR PREPARATION, PHARMACCUTIC COMPOSITIONS AND USES OF THE SAME. UY30444A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US81825906P 2006-06-30 2006-06-30
US90842807P 2007-03-28 2007-03-28

Publications (1)

Publication Number Publication Date
UY30444A1 true UY30444A1 (en) 2008-01-31

Family

ID=38472858

Family Applications (1)

Application Number Title Priority Date Filing Date
UY30444A UY30444A1 (en) 2006-06-30 2007-06-27 PIRIMIDINE DERIVATIVES, PROCESSES FOR PREPARATION, PHARMACCUTIC COMPOSITIONS AND USES OF THE SAME.

Country Status (13)

Country Link
US (1) US20080004302A1 (en)
EP (1) EP2044063A1 (en)
JP (1) JP2009541480A (en)
KR (1) KR20090024270A (en)
AR (1) AR061737A1 (en)
AU (1) AU2007263655A1 (en)
CA (1) CA2654852A1 (en)
IL (1) IL195731A0 (en)
MX (1) MX2008016523A (en)
NO (1) NO20085217L (en)
TW (1) TW200817391A (en)
UY (1) UY30444A1 (en)
WO (1) WO2008001070A1 (en)

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UA99459C2 (en) * 2007-05-04 2012-08-27 Астразенека Аб 9-(pyrazol-3-yl)- 9h-purine-2-amine and 3-(pyraz0l-3-yl)-3h-imidazo[4,5-b]pyridin-5-amine derivatives and their use for the treatment of cancer
EP2166849A4 (en) * 2007-06-11 2010-09-15 Miikana Therapeutics Inc Substituted pyrazole compounds
PE20091236A1 (en) 2007-11-22 2009-09-16 Astrazeneca Ab PYRIMIDINE DERIVATIVES AS IMMUNOMODULATORS OF TLR7
WO2009150462A1 (en) * 2008-06-11 2009-12-17 Astrazeneca Ab Tricyclic 2,4-diamin0-l,3,5-triazine derivatives useful for the treatment of cancer and myeloproliferative disorders
WO2010005692A2 (en) * 2008-06-16 2010-01-14 E. I. Du Pont De Nemours And Company Insecticidal cyclic carbonyl amidines
MX2011003447A (en) * 2008-09-30 2011-07-29 Astrazeneca Ab Heterocyclic jak kinase inhibitors.
GB0908772D0 (en) 2009-05-21 2009-07-01 Astrazeneca Ab New salts 756
MX2011012337A (en) 2009-05-21 2011-12-08 Dainippon Sumitomo Pharma Co Novel pyrimidine derivatives and their use in the treatment of cancer and further diseases.
US8586581B2 (en) 2009-12-17 2013-11-19 Hoffmann-La Roche Inc Ethynyl compounds useful for treatment of CNS disorders
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EP2571867B1 (en) 2010-05-21 2015-11-04 Noviga Research AB Novel pyrimidine derivatives
WO2012050141A1 (en) * 2010-10-14 2012-04-19 住友化学株式会社 Heteroaromatic ring compound and use thereof for pest control
CN103370317B (en) 2010-12-16 2015-10-07 阿斯利康(瑞典)有限公司 Imidazo[4,5-c]quinolin-1-yl derivatives useful in therapy
WO2012088266A2 (en) 2010-12-22 2012-06-28 Incyte Corporation Substituted imidazopyridazines and benzimidazoles as inhibitors of fgfr3
AU2012230229A1 (en) 2011-03-24 2013-10-10 Noviga Research Ab Novel pyrimidine derivatives
WO2013033862A1 (en) * 2011-09-05 2013-03-14 浙江海正药业股份有限公司 4-substituted-(3-substituted-1h-pyrazole-5-amino)-pyrimidine derivatives having activity of inhibiting protein kinase and use thereof
MX2014014031A (en) 2012-05-18 2015-02-12 Sumitomo Dainippon Pharma Co Ltd Carboxylic acid compounds.
UA125503C2 (en) 2012-06-13 2022-04-13 Інсайт Холдинґс Корпорейшн Substituted tricyclic compounds as fgfr inhibitors
WO2014026125A1 (en) 2012-08-10 2014-02-13 Incyte Corporation Pyrazine derivatives as fgfr inhibitors
JP6183053B2 (en) * 2012-08-22 2017-08-23 宇部興産株式会社 Method for producing tetrahydropyranylpyrimidine compound
US9266892B2 (en) 2012-12-19 2016-02-23 Incyte Holdings Corporation Fused pyrazoles as FGFR inhibitors
WO2014172644A2 (en) 2013-04-19 2014-10-23 Incyte Corporation Bicyclic heterocycles as fgfr inhibitors
KR102431436B1 (en) 2014-08-29 2022-08-10 테스 파마 에스.알.엘. INHIBITORS OF α-AMINO-β-CARBOXYMUCONIC ACID SEMIALDEHYDE DECARBOXYLASE
US10851105B2 (en) 2014-10-22 2020-12-01 Incyte Corporation Bicyclic heterocycles as FGFR4 inhibitors
UA121669C2 (en) 2015-02-20 2020-07-10 Інсайт Корпорейшн BICYCLIC HETEROCYCLES AS FGFR INHIBITORS
US9580423B2 (en) 2015-02-20 2017-02-28 Incyte Corporation Bicyclic heterocycles as FGFR4 inhibitors
MA41551A (en) 2015-02-20 2017-12-26 Incyte Corp BICYCLIC HETEROCYCLES USED AS FGFR4 INHIBITORS
AU2016224974B2 (en) * 2015-02-27 2019-09-26 Verseon Corporation Substituted pyrazole compounds as serine protease inhibitors
EA035226B1 (en) 2016-04-28 2020-05-19 ТЕРЕВАНС БАЙОФАРМА Ар энд Ди АйПи, ЭлЭлСи Pyrimidine compounds as jak kinase inhibitors
WO2018132326A1 (en) 2017-01-10 2018-07-19 National Health Research Institutes Heterocyclic compounds and use thereof
AR111960A1 (en) 2017-05-26 2019-09-04 Incyte Corp CRYSTALLINE FORMS OF A FGFR INHIBITOR AND PROCESSES FOR ITS PREPARATION
MX2020004255A (en) 2017-10-27 2020-07-29 Theravance Biopharma R&D Ip Llc Pyrimidine compound as jak kinase inhibitor.
CN112566912A (en) 2018-05-04 2021-03-26 因赛特公司 Salts of FGFR inhibitors
SI3788047T1 (en) 2018-05-04 2024-11-29 Incyte Corporation Solid forms of an fgfr inhibitor and processes for preparing the same
WO2020185532A1 (en) 2019-03-08 2020-09-17 Incyte Corporation Methods of treating cancer with an fgfr inhibitor
US11155549B2 (en) 2019-04-24 2021-10-26 Theravance Biopharma R&D Ip, Llc Ester and carbonate pyrimidine compounds as JAK kinase inhibitors
EP3959213B1 (en) 2019-04-24 2024-06-05 Theravance Biopharma R&D IP, LLC Pyrimidine jak inhibitors for the treatment of skin diseases
CN110143939A (en) * 2019-05-07 2019-08-20 中国科学技术大学 A kind of method for preparing furan acrylate by furan aldehyde-based compound
US11591329B2 (en) 2019-07-09 2023-02-28 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
US12122767B2 (en) 2019-10-01 2024-10-22 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
EP4045151A1 (en) 2019-10-14 2022-08-24 Incyte Corporation Bicyclic heterocycles as fgfr inhibitors
US11566028B2 (en) 2019-10-16 2023-01-31 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
EP4069695A1 (en) 2019-12-04 2022-10-12 Incyte Corporation Derivatives of an fgfr inhibitor
CA3163875A1 (en) 2019-12-04 2021-06-10 Incyte Corporation Tricyclic heterocycles as fgfr inhibitors
WO2021115560A1 (en) * 2019-12-09 2021-06-17 Rottapharm Biotech S.R.L. New fyn and vegfr2 kinase inhibitors
WO2021146424A1 (en) 2020-01-15 2021-07-22 Incyte Corporation Bicyclic heterocycles as fgfr inhibitors
US12065494B2 (en) 2021-04-12 2024-08-20 Incyte Corporation Combination therapy comprising an FGFR inhibitor and a Nectin-4 targeting agent
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CA3220155A1 (en) 2021-06-09 2022-12-15 Incyte Corporation Tricyclic heterocycles as fgfr inhibitors
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CN115466234B (en) * 2022-10-25 2024-01-30 安徽华业香料股份有限公司 Preparation method of gamma-heptanolide

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US6660731B2 (en) * 2000-09-15 2003-12-09 Vertex Pharmaceuticals Incorporated Pyrazole compounds useful as protein kinase inhibitors
US7473691B2 (en) * 2000-09-15 2009-01-06 Vertex Pharmaceuticals Incorporated Pyrazole compounds useful as protein kinase inhibitors
US6613776B2 (en) * 2000-09-15 2003-09-02 Vertex Pharmaceuticals Incorporated Pyrazole compounds useful as protein kinase inhibitors
KR20030032035A (en) * 2000-09-15 2003-04-23 버텍스 파마슈티칼스 인코포레이티드 Pyrazole compounds useful as protein kinase inhibitors
MXPA03005610A (en) * 2000-12-21 2003-10-06 Vertex Pharma Pyrazole compounds useful as protein kinase inhibitors.
SE0104140D0 (en) * 2001-12-07 2001-12-07 Astrazeneca Ab Novel Compounds
US7579349B2 (en) * 2003-10-17 2009-08-25 Astrazeneca Ab 4-(pyrazol-3-ylamino) pyrimidine derivatives for use in the treatment of cancer
MY141220A (en) * 2003-11-17 2010-03-31 Astrazeneca Ab Pyrazole derivatives as inhibitors of receptor tyrosine kinases
JP5208516B2 (en) * 2004-12-30 2013-06-12 エグゼリクシス， インコーポレイテッド Pyrimidine derivatives as kinase modulators and methods of use

Also Published As

Publication number Publication date
CA2654852A1 (en) 2008-01-03
EP2044063A1 (en) 2009-04-08
IL195731A0 (en) 2009-09-01
NO20085217L (en) 2009-01-12
AR061737A1 (en) 2008-09-17
JP2009541480A (en) 2009-11-26
AU2007263655A1 (en) 2008-01-03
MX2008016523A (en) 2009-01-19
TW200817391A (en) 2008-04-16
WO2008001070A1 (en) 2008-01-03
KR20090024270A (en) 2009-03-06
US20080004302A1 (en) 2008-01-03

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Legal Events

Date Code Title Description
DESI Application deemed to be withdrawn

Effective date: 20120606