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UY28214A1 - Nuevos compuestos heteroaromáticos condensados que son inhibidores del factor de crecimiento transformante (tgf) - Google Patents

Nuevos compuestos heteroaromáticos condensados que son inhibidores del factor de crecimiento transformante (tgf)

Info

Publication number
UY28214A1
UY28214A1 UY28214A UY28214A UY28214A1 UY 28214 A1 UY28214 A1 UY 28214A1 UY 28214 A UY28214 A UY 28214A UY 28214 A UY28214 A UY 28214A UY 28214 A1 UY28214 A1 UY 28214A1
Authority
UY
Uruguay
Prior art keywords
tgf
growth factor
inhibitors
heteroaromatic compounds
transforming growth
Prior art date
Application number
UY28214A
Other languages
English (en)
Inventor
Laura Cook Blumberg
Michael John Munchhof
Andre Shavnya
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=32962623&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UY28214(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of UY28214A1 publication Critical patent/UY28214A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurosurgery (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Emergency Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cardiology (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Steroid Compounds (AREA)

Abstract

Se describen nuevos compuestos heteroaromáticos condensados, incluídos sus derivados, intermedios para su preparación, composiciones farmacéuticas que los contienen y su uso medicinal.Los compuestos de la presente invención son potentes inhibidores de la ruta senalizadora del factor de crecimiento transformante ("TGF")-B.Son útiles en el tratamiento de enfermedades relacionadas con TGF-B incluidas, por ejemplo, cáncer y enfermedades fibróticas.
UY28214A 2003-03-04 2004-03-02 Nuevos compuestos heteroaromáticos condensados que son inhibidores del factor de crecimiento transformante (tgf) UY28214A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US45168303P 2003-03-04 2003-03-04

Publications (1)

Publication Number Publication Date
UY28214A1 true UY28214A1 (es) 2004-09-30

Family

ID=32962623

Family Applications (1)

Application Number Title Priority Date Filing Date
UY28214A UY28214A1 (es) 2003-03-04 2004-03-02 Nuevos compuestos heteroaromáticos condensados que son inhibidores del factor de crecimiento transformante (tgf)

Country Status (14)

Country Link
US (2) US7417041B2 (es)
EP (1) EP1601676A2 (es)
JP (1) JP2006519249A (es)
AR (1) AR043449A1 (es)
BR (1) BRPI0407999A (es)
CA (1) CA2517933C (es)
GT (1) GT200400032A (es)
MX (1) MXPA05008148A (es)
NL (1) NL1025623C2 (es)
PA (1) PA8595001A1 (es)
PE (1) PE20050306A1 (es)
TW (1) TW200504069A (es)
UY (1) UY28214A1 (es)
WO (1) WO2004078110A2 (es)

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Also Published As

Publication number Publication date
CA2517933C (en) 2009-05-12
PA8595001A1 (es) 2004-09-28
US20040176390A1 (en) 2004-09-09
CA2517933A1 (en) 2004-09-16
NL1025623C2 (nl) 2005-03-14
JP2006519249A (ja) 2006-08-24
NL1025623A1 (nl) 2004-09-07
TW200504069A (en) 2005-02-01
WO2004078110A3 (en) 2004-11-11
PE20050306A1 (es) 2005-05-16
WO2004078110A2 (en) 2004-09-16
AR043449A1 (es) 2005-07-27
MXPA05008148A (es) 2005-09-30
EP1601676A2 (en) 2005-12-07
BRPI0407999A (pt) 2006-03-07
US20080275235A1 (en) 2008-11-06
US7417041B2 (en) 2008-08-26
GT200400032A (es) 2004-10-21

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