UY28581A1 - Compuestos nucleosidicos para el tratamiento de infecciones virales - Google Patents
Compuestos nucleosidicos para el tratamiento de infecciones viralesInfo
- Publication number
- UY28581A1 UY28581A1 UY28581A UY28581A UY28581A1 UY 28581 A1 UY28581 A1 UY 28581A1 UY 28581 A UY28581 A UY 28581A UY 28581 A UY28581 A UY 28581A UY 28581 A1 UY28581 A1 UY 28581A1
- Authority
- UY
- Uruguay
- Prior art keywords
- treatment
- viral infections
- compounds
- nucleosidic compounds
- nucleosidic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/14—Pyrrolo-pyrimidine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Genetics & Genomics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Virology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Compuestos, composiciones y métodos para el tratamiento de infecciones virales causadas por un virus de la familia Flaviviridae, tal como el virus de la hepatitis C.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US51515303P | 2003-10-27 | 2003-10-27 | |
| US10/861,090 US7202223B2 (en) | 2003-10-27 | 2004-06-04 | Nucleoside compounds for treating viral infections |
| US60281504P | 2004-08-18 | 2004-08-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UY28581A1 true UY28581A1 (es) | 2005-05-31 |
Family
ID=34557362
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UY28581A UY28581A1 (es) | 2003-10-27 | 2004-10-26 | Compuestos nucleosidicos para el tratamiento de infecciones virales |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US7157434B2 (es) |
| EP (1) | EP1680436A1 (es) |
| JP (1) | JP2007509939A (es) |
| KR (1) | KR20060096487A (es) |
| AR (1) | AR046202A1 (es) |
| AU (1) | AU2004285923A1 (es) |
| BR (1) | BRPI0415883A (es) |
| CA (1) | CA2542776A1 (es) |
| IL (1) | IL174685A0 (es) |
| MX (1) | MXPA06004680A (es) |
| NO (1) | NO20062146L (es) |
| SV (1) | SV2005001920A (es) |
| TW (3) | TW200528466A (es) |
| UY (1) | UY28581A1 (es) |
| WO (1) | WO2005042556A1 (es) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY164523A (en) * | 2000-05-23 | 2017-12-29 | Univ Degli Studi Cagliari | Methods and compositions for treating hepatitis c virus |
| CA2410579C (en) * | 2000-05-26 | 2010-04-20 | Jean-Pierre Sommadossi | Methods and compositions for treating flaviviruses and pestiviruses |
| CN1678326A (zh) * | 2002-06-28 | 2005-10-05 | 埃迪尼克斯(开曼)有限公司 | 用于治疗黄病毒感染的2'-c-甲基-3'-o-l-缬氨酸酯核糖呋喃基胞苷 |
| US7608600B2 (en) * | 2002-06-28 | 2009-10-27 | Idenix Pharmaceuticals, Inc. | Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections |
| CN101172993A (zh) | 2002-06-28 | 2008-05-07 | 埃迪尼克斯(开曼)有限公司 | 用于治疗黄病毒感染的2′-c-甲基-3′-o-l-缬氨酸酯核糖呋喃基胞苷 |
| JP2006519753A (ja) * | 2002-11-15 | 2006-08-31 | イデニクス(ケイマン)リミテツド | 2’−分枝ヌクレオシドおよびフラビウイルス科ウイルス突然変異 |
| MXPA05006230A (es) | 2002-12-12 | 2005-09-20 | Idenix Cayman Ltd | Proceso para la produccion de nucleosidos ramificados-2'. |
| JP2007512359A (ja) | 2003-11-19 | 2007-05-17 | メタバシス・セラピューティクス・インコーポレイテッド | 新規なリン含有甲状腺ホルモン様物質 |
| US20050182252A1 (en) * | 2004-02-13 | 2005-08-18 | Reddy K. R. | Novel 2'-C-methyl nucleoside derivatives |
| WO2006121468A1 (en) | 2004-11-22 | 2006-11-16 | Genelabs Technologies, Inc. | 5-nitro-nucleoside compounds for treating viral infections |
| US7524825B2 (en) | 2005-02-28 | 2009-04-28 | Smithkline Beecham Corporation | Tricyclic-nucleoside compounds for treating viral infections |
| WO2007084157A2 (en) * | 2005-03-23 | 2007-07-26 | Genelabs Technologies, Inc. | Nucleoside prodrugs for treating viral infections |
| WO2006102594A1 (en) * | 2005-03-23 | 2006-09-28 | Genelabs Technologies, Inc. | Nucleoside prodrugs for treating viral infections |
| US7405204B2 (en) * | 2005-04-25 | 2008-07-29 | Genelabs Technologies, Inc. | Nucleoside compounds for treating viral infections |
| CA2606499C (en) | 2005-05-26 | 2017-06-13 | Metabasis Therapeutics, Inc. | Thyromimetics for the treatment of fatty liver diseases |
| EP3130350A1 (en) | 2005-06-08 | 2017-02-15 | Dana-Farber Cancer Institute, Inc. | Methods and compositions for the treatment of persistent infections and cancer by inhibiting the programmed cell death 1 (pd-1)pathway |
| US8067571B2 (en) | 2005-07-13 | 2011-11-29 | Avi Biopharma, Inc. | Antibacterial antisense oligonucleotide and method |
| EP1976382B1 (en) * | 2005-12-23 | 2013-04-24 | IDENIX Pharmaceuticals, Inc. | Process for preparing a synthetic intermediate for preparation of branched nucleosides |
| US8071568B2 (en) * | 2007-01-05 | 2011-12-06 | Merck Sharp & Dohme Corp. | Nucleoside aryl phosphoramidates for the treatment of RNA-dependent RNA viral infection |
| TW200838550A (en) * | 2007-02-09 | 2008-10-01 | Novartis Ag | Organic compounds |
| US7964580B2 (en) * | 2007-03-30 | 2011-06-21 | Pharmasset, Inc. | Nucleoside phosphoramidate prodrugs |
| GB0709791D0 (en) * | 2007-05-22 | 2007-06-27 | Angeletti P Ist Richerche Bio | Antiviral agents |
| WO2010015637A1 (en) * | 2008-08-06 | 2010-02-11 | Novartis Ag | New antiviral modified nucleosides |
| SI2370593T1 (sl) | 2008-11-28 | 2016-08-31 | Emory University | Postopek za določanje učinkovitosti antagonista pd-1 |
| KR20110104074A (ko) | 2008-12-23 | 2011-09-21 | 파마셋 인코포레이티드 | 퓨린 뉴클레오시드의 합성 |
| GB0900914D0 (en) | 2009-01-20 | 2009-03-04 | Angeletti P Ist Richerche Bio | Antiviral agents |
| PL2421879T3 (pl) * | 2009-04-22 | 2014-02-28 | Inst Of Organic Chemistry And Biochemistry As Cr V V I | Nowe nukleozydy 7-deazapurynowe do zastosowań terapeutycznych |
| CN107353317A (zh) | 2010-05-28 | 2017-11-17 | 萨勒普塔医疗公司 | 具有修饰的亚基间键和/或端基的寡核苷酸类似物 |
| WO2012031243A2 (en) | 2010-09-03 | 2012-03-08 | Avi Biopharma, Inc. | dsRNA MOLECULES COMPRISING OLIGONUCLEOTIDE ANALOGS HAVING MODIFIED INTERSUBUNIT LINKAGES AND/OR TERMINAL GROUPS |
| CN105061534A (zh) | 2010-09-22 | 2015-11-18 | 艾丽奥斯生物制药有限公司 | 取代的核苷酸类似物 |
| JP2015500204A (ja) | 2011-11-18 | 2015-01-05 | サレプタ セラピューティクス, インコーポレイテッド | 機能的に修飾されたオリゴヌクレオチドおよびそのサブユニット |
| RU2015148006A (ru) | 2013-04-12 | 2017-05-18 | Ачиллион Фармасютикалз, Инк. | Дейтерированные нуклеозидные пролекарства, применимые для лечения hcv |
| TR201907147T4 (tr) | 2013-07-18 | 2019-06-21 | Taiho Pharmaceutical Co Ltd | Fgfr inhibitörünün aralıklı uygulanmasına yönelik anti-tümör ilaç. |
| EP2947086B1 (en) | 2013-08-12 | 2018-01-03 | Taiho Pharmaceutical Co., Ltd. | Novel fused pyrimidine compound or salt thereof |
| WO2015123352A1 (en) | 2014-02-13 | 2015-08-20 | Ligand Pharmaceuticals, Inc. | Prodrug compounds and their uses |
| CN106687118A (zh) | 2014-07-02 | 2017-05-17 | 配体药物公司 | 前药化合物及其用途 |
| US11020417B2 (en) | 2015-06-04 | 2021-06-01 | Sarepta Therapeutics, Inc | Methods and compounds for treatment of lymphocyte-related diseases and conditions |
| WO2018094265A2 (en) | 2016-11-21 | 2018-05-24 | Viking Therapeutics, Inc. | Method of treating glycogen storage disease |
| CN110996966A (zh) | 2017-06-05 | 2020-04-10 | 维京治疗公司 | 用于治疗纤维化的组合物 |
| WO2019139919A1 (en) | 2018-01-09 | 2019-07-18 | Ligand Pharmaceuticals, Inc. | Acetal compounds and therapeutic uses thereof |
| KR20200138283A (ko) | 2018-03-22 | 2020-12-09 | 바이킹 테라퓨틱스 인코포레이티드 | 결정질 형태, 및 결정질 형태의 화합물을 제조하는 방법 |
| WO2020117962A1 (en) | 2018-12-05 | 2020-06-11 | Viking Therapeutics, Inc. | Compositions for the treatment of fibrosis and inflammation |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4140851A (en) | 1977-11-21 | 1979-02-20 | The United States Of America As Represented By The Department Of Health, Education And Welfare | Synthesis and antitumor activity of 2,4,5-trisubstituted-pyrrolo2,3-d]-pyrimidine nucleosides |
| JPS61229897A (ja) | 1985-04-05 | 1986-10-14 | Nippon Zoki Pharmaceut Co Ltd | 新規ヌクレオシド化合物 |
| US6211158B1 (en) | 1987-04-10 | 2001-04-03 | Roche Diagnostics Gmbh | Desazapurine-nucleotide derivatives, processes for the preparation thereof, pharmaceutical compositions containing them and the use thereof for nucleic acid sequencing and as antiviral agents |
| US4892865A (en) | 1987-12-01 | 1990-01-09 | The Regents Of The University Of Michigan | Pyrrolo[2,3-d]pyrimidine nucleosides as antiviral agents |
| US4927830A (en) | 1988-04-08 | 1990-05-22 | The Regents Of The University Of Michigan | Acyclic pyrrolo[2,3-D]pyrimidine analogs as antiviral agents |
| US4968686A (en) | 1988-04-08 | 1990-11-06 | The Regents Of The University Of Michigan | Acyclic pyrrolo [2,3-d]pyrimidine analogs as antiviral agents |
| US5824796A (en) | 1988-09-28 | 1998-10-20 | Epoch Pharmaceuticals, Inc. | Cross-linking oligonucleotides |
| US5763597A (en) | 1989-09-15 | 1998-06-09 | Metabasis Therapeutics, Inc. | Orally active adenosine kinase inhibitors |
| CA2073500C (en) | 1990-01-11 | 2008-03-25 | Phillip Dan Cook | Compositions and methods for detecting and modulating rna activity and gene expression |
| US5681941A (en) | 1990-01-11 | 1997-10-28 | Isis Pharmaceuticals, Inc. | Substituted purines and oligonucleotide cross-linking |
| CA2154681A1 (en) | 1993-02-03 | 1994-08-18 | Mark David Erion | Adenosine kinase inhibitors comprising lyxofuranosyl derivatives |
| EP0695306A1 (en) | 1993-04-19 | 1996-02-07 | Gilead Sciences, Inc. | Enhanced triple-helix and double-helix formation with oligomers containing modified purines |
| US5798340A (en) | 1993-09-17 | 1998-08-25 | Gilead Sciences, Inc. | Nucleotide analogs |
| AU690587B2 (en) | 1993-09-17 | 1998-04-30 | Gilead Sciences, Inc. | Method for dosing therapeutic compounds |
| US6150510A (en) | 1995-11-06 | 2000-11-21 | Aventis Pharma Deutschland Gmbh | Modified oligonucleotides, their preparation and their use |
| DE4438918A1 (de) | 1994-11-04 | 1996-05-09 | Hoechst Ag | Modifizierte Oligonukleotide, deren Herstellung sowie deren Verwendung |
| US6004939A (en) | 1995-07-06 | 1999-12-21 | Ctrc Research Foundation Board Of Regents | Methods for modulation and inhibition of telomerase |
| WO1997002279A1 (en) | 1995-07-06 | 1997-01-23 | Ctrc Research Foundation | Methods and compositions for modulation and inhibition of telomerase |
| FR2750435B1 (fr) | 1996-06-27 | 1998-08-28 | Appligene Oncor | Procede de formation de complexes d'hybridation dont la stabilite depend peu de la composition en base des deux molecules d'acides nucleiques hybridees |
| US6831069B2 (en) | 1999-08-27 | 2004-12-14 | Ribapharm Inc. | Pyrrolo[2,3-d]pyrimidine nucleoside analogs |
| EP1138689A1 (en) | 2000-03-28 | 2001-10-04 | Roche Diagnostics GmbH | N8- and C8-linked purine bases as universal nucleosides used for oligonucleotide hybridization |
| MY164523A (en) | 2000-05-23 | 2017-12-29 | Univ Degli Studi Cagliari | Methods and compositions for treating hepatitis c virus |
| US20030008841A1 (en) | 2000-08-30 | 2003-01-09 | Rene Devos | Anti-HCV nucleoside derivatives |
| SI1355916T1 (sl) | 2001-01-22 | 2007-04-30 | Merck & Co Inc | Nukleozidni derivati kot inhibitorji RNA-odvisne RNA virusne polimeraze |
| WO2003051899A1 (en) | 2001-12-17 | 2003-06-26 | Ribapharm Inc. | Deazapurine nucleoside libraries and compounds |
| JP2005514401A (ja) | 2001-12-21 | 2005-05-19 | マイクロロジックス バイオテック,インコーポレイテッド | 抗ウイルス性7−デアザl−ヌクレオシド |
| WO2003062256A1 (en) | 2002-01-17 | 2003-07-31 | Ribapharm Inc. | 2'-beta-modified-6-substituted adenosine analogs and their use as antiviral agents |
| AU2003209045B2 (en) * | 2002-02-13 | 2006-12-14 | Isis Pharmaceuticals, Inc. | Methods of inhibiting orthopoxvirus replication with nucleoside compounds |
| US20040014108A1 (en) | 2002-05-24 | 2004-01-22 | Eldrup Anne B. | Oligonucleotides having modified nucleoside units |
| US20040014957A1 (en) | 2002-05-24 | 2004-01-22 | Anne Eldrup | Oligonucleotides having modified nucleoside units |
| US20060264389A1 (en) | 2002-07-16 | 2006-11-23 | Balkrishen Bhat | Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase |
| AU2003254657A1 (en) | 2002-07-25 | 2004-02-16 | Micrologix Biotech Inc. | Anti-viral 7-deaza d-nucleosides and uses thereof |
| US7094768B2 (en) * | 2002-09-30 | 2006-08-22 | Genelabs Technologies, Inc. | Nucleoside derivatives for treating hepatitis C virus infection |
| TW200418498A (en) | 2002-09-30 | 2004-10-01 | Genelabs Tech Inc | Nucleoside derivatives for treating hepatitis C virus infection |
| WO2004043977A2 (en) | 2002-11-05 | 2004-05-27 | Isis Pharmaceuticals, Inc. | 2’-fluoro substituted oligomeric compounds and compositions for use in gene modulations |
-
2004
- 2004-10-20 WO PCT/US2004/034955 patent/WO2005042556A1/en not_active Ceased
- 2004-10-20 KR KR1020067008060A patent/KR20060096487A/ko not_active Withdrawn
- 2004-10-20 CA CA002542776A patent/CA2542776A1/en not_active Abandoned
- 2004-10-20 BR BRPI0415883-0A patent/BRPI0415883A/pt not_active Application Discontinuation
- 2004-10-20 US US10/970,321 patent/US7157434B2/en not_active Expired - Fee Related
- 2004-10-20 MX MXPA06004680A patent/MXPA06004680A/es unknown
- 2004-10-20 AU AU2004285923A patent/AU2004285923A1/en not_active Abandoned
- 2004-10-20 JP JP2006538116A patent/JP2007509939A/ja active Pending
- 2004-10-20 EP EP04810014A patent/EP1680436A1/en not_active Withdrawn
- 2004-10-26 TW TW093132412A patent/TW200528466A/zh unknown
- 2004-10-26 AR ARP040103897A patent/AR046202A1/es unknown
- 2004-10-26 UY UY28581A patent/UY28581A1/es not_active Application Discontinuation
- 2004-10-26 TW TW093132415A patent/TW200524606A/zh unknown
- 2004-10-26 TW TW093132438A patent/TW200524587A/zh unknown
- 2004-10-27 SV SV2004001920A patent/SV2005001920A/es not_active Application Discontinuation
-
2006
- 2006-03-30 IL IL174685A patent/IL174685A0/en unknown
- 2006-05-12 NO NO20062146A patent/NO20062146L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| SV2005001920A (es) | 2005-08-18 |
| CA2542776A1 (en) | 2005-05-12 |
| KR20060096487A (ko) | 2006-09-11 |
| US7157434B2 (en) | 2007-01-02 |
| TW200524587A (en) | 2005-08-01 |
| AU2004285923A1 (en) | 2005-05-12 |
| NO20062146L (no) | 2006-07-21 |
| TW200528466A (en) | 2005-09-01 |
| EP1680436A1 (en) | 2006-07-19 |
| AR046202A1 (es) | 2005-11-30 |
| US20050107312A1 (en) | 2005-05-19 |
| IL174685A0 (en) | 2006-08-20 |
| BRPI0415883A (pt) | 2007-01-09 |
| WO2005042556A1 (en) | 2005-05-12 |
| MXPA06004680A (es) | 2007-04-17 |
| TW200524606A (en) | 2005-08-01 |
| JP2007509939A (ja) | 2007-04-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 109 | Application deemed to be withdrawn |
Effective date: 20150601 |