UY25080A1 - AMINO ACID DERIVATIVES AND THEIR USE AS ANTIVIRAL AGENTS - Google Patents
AMINO ACID DERIVATIVES AND THEIR USE AS ANTIVIRAL AGENTSInfo
- Publication number
- UY25080A1 UY25080A1 UY25080A UY25080A UY25080A1 UY 25080 A1 UY25080 A1 UY 25080A1 UY 25080 A UY25080 A UY 25080A UY 25080 A UY25080 A UY 25080A UY 25080 A1 UY25080 A1 UY 25080A1
- Authority
- UY
- Uruguay
- Prior art keywords
- amino acid
- acid derivatives
- formula
- relates
- alkyl
- Prior art date
Links
- 150000003862 amino acid derivatives Chemical class 0.000 title abstract 3
- 239000003443 antiviral agent Substances 0.000 title 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- -1 aralkoxycarbonyl Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000000383 tetramethylene group Chemical group [H]C([H])([*:1])C([H])([H])C([H])([H])C([H])([H])[*:2] 0.000 abstract 2
- 208000036142 Viral infection Diseases 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000005115 alkyl carbamoyl group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000001584 benzyloxycarbonyl group Chemical group C(=O)(OCC1=CC=CC=C1)* 0.000 abstract 1
- 125000001589 carboacyl group Chemical group 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 1
- 125000006517 heterocyclyl carbonyl group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- UYWQUFXKFGHYNT-UHFFFAOYSA-N phenylmethyl ester of formic acid Natural products O=COCC1=CC=CC=C1 UYWQUFXKFGHYNT-UHFFFAOYSA-N 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
- 125000003258 trimethylene group Chemical group [H]C([H])([*:2])C([H])([H])C([H])([H])[*:1] 0.000 abstract 1
- 230000009385 viral infection Effects 0.000 abstract 1
Landscapes
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
La presente invención se refiere a derivados de aminoácidos, más particularmente se refiere a derivados de aminoácidos de la fórmula (I), y sales de adición de ácido farmacéuticamente aceptables de aquellos compuestos de la fórmula (I) que son básicos, en donde: R1 representa alcoxicarbonilo, aralcoxicarbonilo, alcanoilo, aralcanoilo, heterociclilcarbonilo o R8HN-CR9-CO-CH3; R2 representa alquilo, cicloalquilalquilo o aralquilo; R3 representa hidrógeno y R4 representa hidroxilo o R3 y R4 representan oxo; R5 representa alcoxicarbonilo o alquilcarbamoilo; R6 y R7 juntos representan trimetileno o tetrametileno opcionalmente sustituido por alquilo o en átomos de carbono adyacentes por tetrametileno. Por ejemplo: 2(S)-(3(S)-((N-(benciloxicarbonil)-3-ciano-L-alanil)amino)-2®-hidroxi-4-fenilbutil)-N-terci.butil-1®-ciclohexancarboxamida. La presente invención se refiere también a un procedimiento para la preparación de compuestos de fórmula (I). Se utilizan para la profilaxis o el tratamiento de infecciones virales.The present invention relates to amino acid derivatives, more particularly relates to amino acid derivatives of formula (I), and pharmaceutically acceptable acid addition salts of those compounds of formula (I) which are basic, wherein: R1 represents alkoxycarbonyl, aralkoxycarbonyl, alkanoyl, aralcanoyl, heterocyclylcarbonyl or R8HN-CR9-CO-CH3; R2 represents alkyl, cycloalkylalkyl or aralkyl; R3 represents hydrogen and R4 represents hydroxyl or R3 and R4 represent oxo; R5 represents alkoxycarbonyl or alkylcarbamoyl; R6 and R7 together represent trimethylene or tetramethylene optionally substituted by alkyl or in adjacent carbon atoms by tetramethylene. For example: 2 (S) - (3 (S) - ((N- (benzyloxycarbonyl) -3-cyano-L-alanyl) amino) -2®-hydroxy-4-phenylbutyl) -N-tert.butyl-1 ®-cyclohexancarboxamide. The present invention also relates to a process for the preparation of compounds of formula (I). They are used for the prophylaxis or treatment of viral infections.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| UY25080A UY25080A1 (en) | 1998-06-02 | 1998-06-02 | AMINO ACID DERIVATIVES AND THEIR USE AS ANTIVIRAL AGENTS |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| UY25080A UY25080A1 (en) | 1998-06-02 | 1998-06-02 | AMINO ACID DERIVATIVES AND THEIR USE AS ANTIVIRAL AGENTS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UY25080A1 true UY25080A1 (en) | 2001-03-16 |
Family
ID=38812090
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UY25080A UY25080A1 (en) | 1998-06-02 | 1998-06-02 | AMINO ACID DERIVATIVES AND THEIR USE AS ANTIVIRAL AGENTS |
Country Status (1)
| Country | Link |
|---|---|
| UY (1) | UY25080A1 (en) |
-
1998
- 1998-06-02 UY UY25080A patent/UY25080A1/en not_active Application Discontinuation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 109 | Application deemed to be withdrawn |
Effective date: 20121206 |