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USRE27894E - Hydroxy-j-(j-phenylureido)crotonic acid, gamma lactone compounds - Google Patents

Hydroxy-j-(j-phenylureido)crotonic acid, gamma lactone compounds Download PDF

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USRE27894E
USRE27894E US27894DE USRE27894E US RE27894 E USRE27894 E US RE27894E US 27894D E US27894D E US 27894DE US RE27894 E USRE27894 E US RE27894E
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hydroxy
oxo
pyrroline
phenylureido
crotonic acid
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/66—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical

Definitions

  • This invention relates to novel 4-hydr0xy-3-(-3-phenylureido)crot0nic acid, gamma Iactone compounds [4-hydroxy-2-oxo-3-pyrro1ine-l-carboxanilides] and their use as defoilants and plant growth retardants.
  • compositions and methods employing, as an active ingredient, at least one compound of the formula ii km illil where:
  • R is hydrogen, halogen, methyl or ethyl
  • R and R are each independently selected from hydrogen or alkyl of one through three carbon atoms
  • R is hydrogen or alkyl of one through four carbon atoms; and salts of said compounds when R is hydrogen with an alkali metal ion, alkaline earth metal ion, ammonium ion or H (R N+ where R, is an alkyl radical of one through four carbon atoms or benzyl and y is 0 to three.
  • gamma lacrone, lithium, sodium and potassium salts 2-chloro-4-hydroxy-3-(3-methyI-3-phenylureido)crotonic acid, gamma Iacrone, and its lithium, sodium, and p0- tassium salts 2-bromo-4-hydroxy-3-(3-methyl-3-phenylureido)crotonic acid, gamma lactone, and its lithium, sodium, and potassium salts
  • the salts are preferred because of their water solubility resulting in greater handling ease.
  • Rt /0 o R 1 0 where R R and R have the same meaning as in structure (I) with the exceptions made and X designates chlorine or bromine.
  • R [R is lower alkyl such as methyl, ethyl, benzyl.
  • reaction product of reaction (II) may be alkylated with Meerwein reagent according to the equation:
  • the appropriately substituted ethyl acetoacetate and the unsubstituted phenylurea or l alkyl-l-phenylurea are dissolved or suspended in a suitable organic solvent such as xylene, toluene, benzene, dibutylether, tetrahydrofuran, or dioxane.
  • a suitable organic solvent such as xylene, toluene, benzene, dibutylether, tetrahydrofuran, or dioxane.
  • the product may be filtered and washed with a suitable solvent such as ethanol, methanol or ether to yield essentially pure product, which, however, may be recrystallized from a solvent such as methanol, ethanol, or a dimethylformamide-water mixture;
  • a suitable solvent such as ethanol, methanol or ether
  • the solvent may be stripped off in vacuo and the residue dissolved in a water immiscible solvent such as chloroform, methylene chloride, or diethyl ether.
  • a water immiscible solvent such as chloroform, methylene chloride, or diethyl ether.
  • This solution is then extracted with aqueous base, the resulting solution separated from the organic layer and acidified with a mineral acid.
  • the precipitate is collected on a filter and treated as before;
  • the residue may be directly recrystallized from a suitable solvent, such as an alcohol, a ketone, a dimethylformamide-water mixture, etc.
  • a suitable solvent such as an alcohol, a ketone, a dimethylformamide-water mixture, etc.
  • Ethyl a-fiuoroacetoacetate may be synthesized as follows:
  • the substituted [4-hydroxy-2-oxo 3 pyrroline 1 carboxanilide,] 4-hydroxy-3-(3-phenylureido)crotonic acid, gamma lactone obtained as described under (II), may be halogenated:
  • the starting material is dissolved or dispersed in glacial acetic acid, a half-equimolar amount of iodine added and subsequently an equimolar amount of fuming nitric acid.
  • X represents the nitrogeneous base named under
  • a suitable solvent such as an alcohol, ketone, or hydrocarbon, etc.
  • an equimolar amount of the appropriate base such as alkali or earth alkali metal hydroxide, alkoxide, amide, or hydride, substituted or unsubstituted ammonium hydroxide, or amine is added, and the resulting mixture or solution stirred and refluxed for some time.
  • the solvent is evaporated and the product collected.
  • compositions which make application to the plants easier and which permit easy penetration of the plant foliage.
  • These compositions may be, in the case of the water soluble salts, simple aqueous solutions or they may be the defoliant compounds in combination with pesticidal carriers and/or surface active agents.
  • Such compositions may be in the form of soluble or wettable powders, aqueous suspensions or dusts.
  • the surface-active agents or surfactants can include any of the anionic, cationic and non-ionic surface-active agents. A detailed list of such agents is set forth in Detergents and Emulsifiers 1967 Annual by John W. McCutcheon, Inc.
  • surfactants are those anionic and non-ionic agents recognized in the art as wetting agents, dispersing agents, detergents or emulsifiers.
  • anionic surfactants preferred ones are alkali metal or amine salts of alkylbenzenesulfonic acids such as dodecylbenzenesulfonic acid, alkali metal or amine salts of sulfated alcohols such as sodium lauryl sulfate, alkali metal or amine salts of alkynaphthalene sulfonates, sodium N-methyl-N-oleoyltaurate, oleic acid ester of sodium isethionate, dialkyl esters of sodium sulfosuccinic acid such as dioctyl sodium sulfosuccinate, and sodium dodecyldiphenyl oxide disulfonate.
  • non-ionic compounds preferred members include alkylphenoxy poly(ethyleneoxy)ethanols such as nonylphenol adducts with ethylene oxide; trimethylnonyl polyethylene glycol ethers, polyethylene oxide adducts with fatty and rosin acids, ethylene oxide adducts with sorbitan fatty acid esters, and long chain alcohol or mercaptan adducts with ethylene oxide.
  • alkylphenoxy poly(ethyleneoxy)ethanols such as nonylphenol adducts with ethylene oxide; trimethylnonyl polyethylene glycol ethers, polyethylene oxide adducts with fatty and rosin acids, ethylene oxide adducts with sorbitan fatty acid esters, and long chain alcohol or mercaptan adducts with ethylene oxide.
  • surfactants are also dispersants such as methyl cellulose, polyvinyl alcohol, sodium lignin sulfonates, polymeric alkylnaphthalene sulfonates, and polymethylene bis sulfonates.
  • Surfactants can be present in compositions of this invention in the range of 0.1 to 20% by weight. However, in some instances, even greater proportions of surfac tants can be used.
  • compositions particularly suitable for water-insoluble compounds of this invention are aqueous suspension concentrates such as the ones described in US. Patent 3,060,084 and in US. Patent 3,157,486.
  • Aqueous suspension concentrates are very desirable because of their convenience in handling and use.
  • compositions can be formulated by adding a free-flowing inert powder to the active agents. Such compositions can then be Wettable powders, water-soluble powders, or dusts.
  • Wettable powder compositions contain the active ingredient, one or more surfactants, and a finely divided inert diluent.
  • the finely divided inert diluent can be any of the extenders commonly employed in the art. They can include natural clays including attapulgite or kaolinite, diatomaceous earth, pyrophyllite, talc, synthetic mineral fillers derived from silica and silicates such as synthetic fine silica and synthetic calcium or magnesium silicate, carbonates, phosphates and sulfates, sulfur, lime and flours such as wood, walnut shell, redwood, soybeans and cottonseed. Particle size of the extender can vary considerably but will ordinarily be somewhat under 50 microns in the finished formulation.
  • the active compound ordinarily will be present in a concentration in the range of 25 to by weight.
  • Surfactants will be present in a range from 0.1 to 10% by weight to obtain adequate wetting and dispersion in water, with the remainder being largely one or more of the finely divided diluents shown above.
  • Wettable powders are prepared by mixing the ingredients in a blender and grinding the mixture in a hammer mill, air impact mill or the like until the particle size has been reduced to make spray application practical and easy.
  • Wettable powders and aqueous suspension compositions are frequently used by dilution and extension with water to form spray slurry compositions containing from 0.05% to 3% of the active ingredient.
  • compositions of the water soluble compounds of this invention are the water soluble powders. These may be the active compound with water soluble neutral compounds and/or surfactants, or these compositions may be the active compounds in combination with alkaline water soluble salts to increase the solubility and/or the rate of solution of the active compounds. These compositions containing basic salts can of course also contain water soluble neutral compounds. Small amounts of anticaking agents can also be present in watersoluble compositions. Such anticaking agents may also be water-soluble, but more frequently will be chosen from the finely divided inert diluents, such as are used with Wettable powders.
  • the soluble powders will comprise 20 to active, 0-5% anticaking agent, 0-5% surfactant and the remainder a water-soluble base and/or a water-soluble diluent.
  • Such compositions are prepared by blending and grinding the ingredients to obtain a homogeneous pulverulent mixture. If the ingredients are already in a sufficiently fine state of subdivision to make rapid dissolution practical, mere blending will usually be sufficient.
  • compositions may contain additives such as corrosion inhibitors, antifoam agents and the like.
  • Dusts are dense powder compositions which are intended for application in dry form. They are characterized by free-flowing, rapid settling properties, so that they are not readily wind-borne to areas where their presence is not desired. Dusts contain primarily the active compound and a dense, free-flowing solid extender. It is sometimes desirable to include a wetting agent, and convenience in manufacture frequently requires inclusion of an inert absorptive grinding aid.
  • the dense, free-flowing solid extenders usually are those organic or inorganic powders which possess high bulk density, are free-flowing, and have relatively low surface area and liquid adsorptivity. Suitable such extenders are micaceous talcs, pyrophyllite, dense kaolin clays, ground calcium phosphate rock (Phosphodust, American Agricultural Chemical Company), sericite, tobacco dust, etc.
  • the grinding aids and surface active agents can be the same as have been described for preparation of the wettable powders, above.
  • wettable powders may be used in the preparation of dusts by dilution with the dense, free-flowing solid extender. While such wettable powders could be used directly in dust form, it is usually more advantageous to dilute them with these dense dust diluents in order to obtain more rapid settling and more uniform distribution.
  • the water-soluble powder composition can also be used in the preparation of dusts by dilution with the dense free-flowing solid extender.
  • the dust compositions of this invention will comprise about 330% active material, -3070 grinding aid, 03% surface active agent, the remainder being the extender. These dusts are prepared by blending the ingredients and grinding to obtain homogeneous pulverulent mixtures. If the ingredients are already finely divided, thorough blending will usually suffice for the preparation of a dust.
  • the precipitate is filtered, washed with water, and recrystallized from an ethanol-water mixture to yield 6 parts by weight of [4 hydroxy-N-methyl-2-oxo-3-pyrroline-1-carboxanilide] 4-hydr0xy-3-methyi-3-phenylureido)crotonic acid, gamma lactone, M.P. 197-198 C.
  • EXAMPLE 7 Preparation of the sodium salt of [3-bromo-4-hydroxy- 2-oxo-3-pyrroline-l-carboxanilide] 2-bram0-4-hydr0xy- 3-(3-phenylureido)crotonic acid, gamma lactone 2.5 parts by weight of [3-bromo-4-hydroxy-2-oxo-3- pyrroline-l-carboxanilide] 2-bromo-4-hydroxy-3-(3-phenylureido)crotonic acid, gamma lactone is suspended in 100 parts by weight of methanol. 1.5 parts by weight of sodium methoxide is added and the mixture is stirred. A clear solution results after about half an hour. The solvent is stripped in vacuo, and the solid residue collected and finely pulverized. Nine parts by weight of the above sodium salt is obtained, M.P. 190 C. dec.
  • potassium, and lithium salts a-hydroxy-Z-oxo-3-pyrroline-l-carboxanilide, magnesium, calcium, barium salts 3-chloro-4-hydroxy-2-oxo-3-pyrroline-l-carboxanilide,
  • magnesium, calcium, barium salts 4-hydroxy-2-oxo-3-pyrroline-l-(N-methylcarboxanilide), ammonium salt 4hydroxy-2-oxo-3-pyrroline-1-(N-ethylcarboxanilide),
  • tetramethyl ammonium salt 4-hydroxy-2-oxo-3-pyrroline-1-(N-isopropylcarboxanilide), benzylamine salt 4-hydroxy-5-ethyl-2-oxo-3-pyrroline-1-carboxani1ide,
  • the ingredients are combined in a ribbon blender and ground in a hammer mill to insure intimate mixing.
  • An aqueous solution containing 3 kilograms of the sodium salt of [4-hydroxy-2-oxo-3-pyrroline-l-carboxanilide] 4-hydroxy-3-(3-phenylureido)crotonic acid, gamma lactone in 400 l. of water is prepared and sprayed uniformly over a hectare of bluegrass turf after the second morning in the spring.
  • the treatment retards the growth of the grass through the spring and markedly reduces the number of mowings necessary to maintain the neat appearance of the turf compared to similar untreated areas.
  • EXAMPLE A water soluble powder formulation Percent [4 hydroxy 2 oxo 3 pyrroline l carboxanilide] 4-hydroxy-3-(3-phenylureido)crotonic acid, gamma iactonc 95.0
  • the subsequently harvested crop is of higher quality than soybeans harvested from a neighboring untreated field.
  • EXAMPLE 11 A wettable powder formulation Percent [3 chloro 4 hydroxy 2 oxo 3 pyrroline 1- carboxanilide] 2 chI0r04-hydr0xy-3-(3-phenyiureid0)crotonic acid, gamma lactone 50.0 Sodium lauryl sulfate 0.5 Calcium lignin sulfonate 2.0
  • the ingredients are combined in a ribbon blender and ground in a hammer mill until the particle size is essentially less than 50 microns in diameter.
  • composition described above is dispersed in water to a concentration of 0.15%, based on the weight of [3 chloro 4 hydroxy 2 oxo 3 pyrroline 1- carboxanilide] 2-chloro 4 hydran -3-(3-p-henylureido) crotonic acid, gamma lactone.
  • S,S,S-tributyl ester of phosphorotrithious acid in the form of an emulsifiable concentrate (commercially available under the trademark Folex) in an amount sufficient to raise the total content of active ingredients in the suspension to 0.3%.
  • the accordingly prepared suspension is applied by ground sprayer to a field of cotton which is approaching maturity.
  • the rate of application is 0.5 kg./ hectare of each of the two active ingredients.
  • the treatment results in substantially complete defoliation and/or desiccation of the leaves of the cotton plants.
  • the devel opment of new leaves is retarded. No difficulties are encountered in harvesting the treated field by machine.
  • the harvested bolls contain significantly less trash than those from an untreated control strip.
  • EXAMPLE 12 An aqueous suspension formulation Kaolin clay Percent [3 bromo 4 hydroxy 2 oxo 3 pyrrolidinel-carboxanilide] 2-bromo-4-hydraxy-3-(3-phenyl- All of the ingredients are blended together and ground in a sand mill until the particles are essentially less than 10 microns in diameter.
  • This composition is suspended in water to give an aqueous dispersion containing 0.2% of the substituted [pyrroline-carboxanilide] 4-hydrotx-y-3-(3-phenylureido) crotonic acid, gamma lacrone compound.
  • the spray composition is applied to a maturing field of tomato plants, utilizing 0.65 kg./hectare of active ingredient, and causes most of the leaves to drop within eight days after treatment.
  • the fruit of the defoliated plants ripens more easily 351d is less subject to disease than the fruit from control p ots.
  • EXAMPLE 13 The formulation is prepared by blending the ingredients in a ribbon blender or similar device and grinding the mixture in a hammer mill to insure intimate mixing.
  • composition is extended with water to a concentration of 0.35% of the sodium salt.
  • a volume of 250 liters of this freshly prepared solution is uniformly applied to a maturing field of seed alfalfa causing abcissions of most of the leaves.
  • the absence of succulent foliage permits direct combining of seed from the treated field.
  • EXAMPLE 14 A water soluble salt formulation Percent [4 hydroxy 2 oxo 3 pyrroline 1 carboxanilide] 4-hydr0xy 3 (3-phenyl'ureido) crotonic acid, gamma lactane, lithium salt 50.0 Sodium lauryl sulfate 0.5 Sodium meta-silicate, anhydrous 23.5 Potassium carbonate 26.0
  • the formulation is prepared by blending the ingredients and grinding in a hammer mill to insure intimate mixing.
  • the above composition is extended with water to give an ultimate concentration of 1.2% of the lithium salt of the substituted pyrrolidine carboxanilide compound.
  • This liquid spray composition is applied in a volume of 300 l./hectare to a field of cotton which is at the stage of development where the first bolls are open. After six to eight days most of the leaves fall to the ground while still green. The field matures much more uniformly than an adjacent untreated field and is readily harvested by mechanical means.
  • EXAMPLE 15 A dust formulation Percent [3 chloro 4 hydroxy 2 oxo 3 pyrrolidinel-carboxanilide] 2-chl0r0-4-hydroxy-3- (3-phenylureido) crotonic acid, gamma lactone Calcium silicate 10 Calcium carbonate coated with calcium stearate 80 The active ingredient and the calcium silicate are blended together and ground in a hammer mill. This intimate mix is then charged to a ribbon blender along with the coated calcium carbonate. The mixture is thoroughly blended to insure uniform distribution of the active ingredient throughout the dust.
  • the above dust composition is applied to a maturing cotton field in the early morning when the plants are wet from dew at the rate of 30 kg./hectare and causes almost complete defoliation of the crop plants.
  • the defoliated area is harvested by machine and yields a highly satisfactory crop of stainfree and trashfree lint.
  • EXAMPLE 16 A wettable powder formulation Percent [4-ethoxy 2 oxo-3-pyrroline-l-carboxanilide] 4-hydroxy 3 (1 ethyl-3-phenylureid0)crotonic acid,
  • gamma laczone 30 Sodium alkylnaphthalenesulfonate 2 Sodium lignin sulfonate 2 Attapulgite 66 The ingredients are blended, passed through an air mill until the average particle size is microns, reblended, sifted through a USS #50 sieve (0.3 mm. opening), and packaged.
  • This formulation is applied to mature cotton approximately ten days before harvest at the rate of 2 kg./ha. (active ingredient) suspended in 250 liters of Water.
  • the treatment provides good defoliation of the cotton, and facilitates mechanical harvesting of the cotton fibers.
  • composition is dispersed in water and applied by air to a maturing field of cotton at a rate of 10 kg. of [pyrroline carboxanilide] 2-br0mo-4-hydroxy-3-(3-phenylureid0) crotonic acid, gamma lacrone compound per hectare.
  • the spray volume is 45 liters per hectare. Soon after treatment the sprayed plants shed most of their leaves thereby permitting the bolls to mature. At full maturity [of] the crop is harvested by machine, yielding a large volume of high-quality lint.
  • the compounds of the present invention at rates of 0.25 to 30 kg. per hectare are useful for the defoliation of a large variety of plants, thereby aiding maturation and/or facilitating the harvesting operation.
  • crops which benefit from the application of the harvest aids in accordance with the invention are cotton, legume and grass seed crops, soybeans, kidney beans and other beans, tomatoes, etc. These compounds are also useful for the retardation of the growth of grasses and brush. On many species including Kentucky bluegrass, prinet and forsythia they cause retardation of growth with little plant injury. On other species, such as orchard grass and black willow they cause injury in addition to retardation.
  • these compounds may be used to retard the growth of plants and, thereby, reduce the labor required to maintain them at a desirable size. This retardant effect is also useful in the prevention of regrowth of defoliated plants.
  • the compounds of the invention may be applied in liquid or dry compositions either by themselves or mixed with other harvest aids which are commonly known in the art, such as the S,S,S-tributyl ester of phosphorotrithious acid, pentachlorophenol, sodium or magnesium chlorate, calcium cyanamid, ammonium nitrate, arsenic acids and others.
  • R is hydrogen or chlorine, R, is methyl, R is hydrogen and salts of said compound with lithium ions, sodium ions and potassium 3.
  • a compound as in claim 1 having the formula [3- chloro 4 hydroxy-2-oxo-3-pyrroline-l-carboxanilide] 2- chloro 4 hydroxy 3 (3-phenylureid0)crotonic acid, gamma lactone.

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Abstract

NOVEL COMPOUNDS ARE PRESENTED WHICH HAVE THE FOLLOWING STRUCTURE (1-(H5C6-N(-R2)-CO-),2-(O=),3-R1,4-(R5-O-),5-R33-PYRAZOLINE

2-R3,3-(H5C6-N(-R2)-CO-N(-R5)-),4-R1,5-(O=)-2,5-DIHYDROFURAN WHEREIN: R1 IS HYDROGEN, HALOGEB, METHYL OR ETHYL, R2 AND R3 ARE INDEPENDENTLY SELECTED FROM THE HYDROGEN OR ALKYL OF ONE THROUGH THREE CARBON ATOMS AND SALTS OF SAID COMPOUNDS WHEN R5 IS HYDROGEN WHERE THE SALT FORMING CONSTITUTENTS IS AN ALKALI METALION, ALKALINE EARTH ALKYL OF ONE THROUGH FOUR CARBON ATOMS OR BENZYL, AND R5 IS HYDROGEN OR ALKYL OR ONE THROUGH FOUR CARBON ATOMS. THESE COMPOUNDS ARE EXCELLENT DEFOLIANTS.

Description

United States Patent 27,894 4-HYDROXY-3-(3-PHENYLUREIDO)CROTONIC ACID, GAMMA LACTONE COMPOUNDS Peter Gerike, Hilden, Germany, assignor to E. I. du Pont de Nemours and Company, Wilmington, Del.
No Drawing. Original No. 3,541,111, dated Nov. 17, 1970, Ser. No. 727,712, May 8, 1968. Application for reissue May 15, 1972, Ser. No. 253,639
Int. Cl. C0711 5/06 US. Cl. 260343.6 8 Claims Matter enclosed in heavy brackets I: appears in the original patent but forms no part of this reissue specification; matter printed in italics indicates the additions made by reissue.
ABSTRACT OF THE DISCLOSURE Novel compounds are presented which have the following structure where:
This invention relates to novel 4-hydr0xy-3-(-3-phenylureido)crot0nic acid, gamma Iactone compounds [4-hydroxy-2-oxo-3-pyrro1ine-l-carboxanilides] and their use as defoilants and plant growth retardants.
More particularly, this invention is directed to compositions and methods employing, as an active ingredient, at least one compound of the formula ii km illil where:
R is hydrogen, halogen, methyl or ethyl;
R and R are each independently selected from hydrogen or alkyl of one through three carbon atoms;
R is hydrogen or alkyl of one through four carbon atoms; and salts of said compounds when R is hydrogen with an alkali metal ion, alkaline earth metal ion, ammonium ion or H (R N+ where R, is an alkyl radical of one through four carbon atoms or benzyl and y is 0 to three.
[When R is hydrogen the compounds (I) may exist in two tantomeric forms (i.e. the 4 position may be keto). Since the enol form seems to be preferred, the structures have been exclusively named as such] Especially preferred for use because of their outstanding defoliating eflectiveness and retardation of plant growth are:
[4-hydroxy-2-oxo-3-pyrroline-l-carboxanilide, sodium salt 4-hydroxy-2-oxo-3-pyrroline-l-carboxanilide, lithium salt 3-chloro-4-hydroxy-2-oxo-3-pyrroline-l-carboxanilide 3-bromo-4-hydroxy-2-oXo-3-pyrroline-l-carboxanilide 3-chloro-4-hydroxy-2-oxo-3-pyrroline-l-carboxanilide,
sodium and potassium salts 3-bromo-4-hydroxy-2-oxo-3-pyrroline-l-carboxanilide,
sodium and potassium salts] 4-hydroxy-3-(3-phenylureido)crotonic acid, gamma lactone, sodium salt 4-hydroxy-3-(3-plzenylurcido)crotonic acid, gamma lactone, lithium salt 2-chloro-4-hydroxy-3-tf3-phenylureido)crotonic acid,
gamma lactone 2-bromo-4-hydroxy-3-(3-phenyl reui'o) crozonic acid,
gamma lactone 2-chloro-4-hydroxy-3-(3-phenylureido)crolonic acid,
gamma lactone, sodium and potassium salts 2-bromo-4-lzydroxy-3-(3-phenylureido) crotonic acid,
gamma lacrone, sodium and potassium salts [4-hydroxy-3-methyl-2-oxo-3-pyrroline-l-carboxanilide 4-hydroxy-3-ethyl-2-oxo-3 -pyrrolinel-carboxanilide 4-hydroxy-2-oxo-3- p yrro1ine- 1- N-methylcarboxa m'lide) lithium, sodium and potassium salts 3-chloro-4-hydroxy-2-oxo-3-pyrroline-l-(N-methylcarboxanilide), and its lithium, sodium and potassium salts 3-bromo-4-hydroxy-2-oxo-3-pyrroline-l-(N-methylcarboxanilide), and its lithium, sodium, and potassium salts] 2-methyl-4-hydr0xy-3-(3-phenylureido)crotonic acid,
gamma lacrone 2-ethyl-4-hydr0xy-3-(3-phenylureido)crotonic acid,
gamma lactone 4-hydr0xy-3-(3-methyl-3-phenylureido)crotonic acid,
gamma lacrone, lithium, sodium and potassium salts 2-chloro-4-hydroxy-3-(3-methyI-3-phenylureido)crotonic acid, gamma Iacrone, and its lithium, sodium, and p0- tassium salts 2-bromo-4-hydroxy-3-(3-methyl-3-phenylureido)crotonic acid, gamma lactone, and its lithium, sodium, and potassium salts The salts are preferred because of their water solubility resulting in greater handling ease.
PREPARATION OF THE COMPOUNDS Those [4-hydroxy-2-oxo-3-pyrroline-l-carboxanilides] 4-hydroxy-3-(3-phenylureido)crotonic acid, gamma lactone compounds where R, i hydrogen, methyl or ethyl, are made according to the following equation:
(II) X1 0 R amal am 111.
Rt /0 o R 1 0 where R R and R have the same meaning as in structure (I) with the exceptions made and X designates chlorine or bromine.
R [R is lower alkyl such as methyl, ethyl, benzyl.
The [enol] reaction product of reaction (II) may be alkylated with Meerwein reagent according to the equation:
The reagent and its reactions are described by H. Mcerwein et al., J. Prakt. Chem., 147, 257 (1937).
The appropriately substituted ethyl acetoacetate and the unsubstituted phenylurea or l alkyl-l-phenylurea are dissolved or suspended in a suitable organic solvent such as xylene, toluene, benzene, dibutylether, tetrahydrofuran, or dioxane. The solution or suspension is stirred and re fiuxed for several hours. The mixture is cooled. In some cases,
(1) the product may be filtered and washed with a suitable solvent such as ethanol, methanol or ether to yield essentially pure product, which, however, may be recrystallized from a solvent such as methanol, ethanol, or a dimethylformamide-water mixture;
(2) or, the solvent may be stripped off in vacuo and the residue dissolved in a water immiscible solvent such as chloroform, methylene chloride, or diethyl ether. This solution is then extracted with aqueous base, the resulting solution separated from the organic layer and acidified with a mineral acid. The precipitate is collected on a filter and treated as before;
(3) or, after stripping off the solvent, the residue may be directly recrystallized from a suitable solvent, such as an alcohol, a ketone, a dimethylformamide-water mixture, etc.
The reactants, substituted ethyl acetoacetate and phenylurea, are easily obtained according to the equation:
(III) 0 R1 0 R1 t e ll 6 lip-CH H-COORc Rt-CHr- BCOOR.
The bromine rearranges easily on standing from the 2- into the 4-position. This reaction is amply described in the literature, see, e.g. M. S. Kharasch, E. Hernfeld, F. R. Mayo, J. Am. Chem. Soc 59, 1655 (1937) or A. Burger, G. E. Ullyot, J. Org. Chem. 12, 342 (1947).
The preparation of ethyl a-chloroacetoacetate according to ALHG: CHnCl-C O OCzH 4 is described by M. Picha, Monath. Chem. 27, 1247 (1906) and, according to by C. D. Hurd, J. L. Abernethy, J. Am. Chem. Soc. 62, 1147 (1940).
Compounds of structure (I) where R is fluorine, are prepared, starting with ethyl ot-fluoroacetoacetate, in the usual fashion. Ethyl a-fiuoroacetoacetate may be synthesized as follows:
(V1) anew-0000.11. cm-coocnn i (VII) For more details, see, e.g. W. Gebhardt, Ber. 17, 2095 (1884).
When R is hydrogen, the substituted [4-hydroxy-2-oxo 3 pyrroline 1 carboxanilide,] 4-hydroxy-3-(3-phenylureido)crotonic acid, gamma lactone obtained as described under (II), may be halogenated:
VIII 0 The compound is dissolved or suspended in glacial acetic acid. An equimolar amount of sulfuryl chloride (X =Cl) or bromine (X =Br) is added dropwise at room temperature with stirring. The product is either filtered or, if a solution is obtained, the product is precipitated by addition of water, collected on a filter, and washed thoroughly with water. The compounds thusly obtained are essentially pure but may be recrystallized from a suitable solvent.
When X is iodine, the starting material is dissolved or dispersed in glacial acetic acid, a half-equimolar amount of iodine added and subsequently an equimolar amount of fuming nitric acid.
The [3-pyrroline 1 carboxanilides] 4-hydroxy-3-(3- phenylureido)crtonic acid, gamma lactone c mpounds obtained according to (II) and (VIII) form salts:
(1x) n| 0 0 R m 110/ Bi E 0 1 we o e X 0 R: H
I o H R 1'13 Ox R1 N-PJ-N N =N- O a R: 0 RI 0 where X+ represents the ions named under (I) i j I R.
1s-rio@ x K HO R: E
-am .s s A.
R: O R
H I 0 X;
X RI 0 o R n, 0 x11 1 1 i m o o where X represents the nitrogeneous base named under The compound obtained in (II) and (VIII) is dispersed or dissolved in a suitable solvent such as an alcohol, ketone, or hydrocarbon, etc., an equimolar amount of the appropriate base such as alkali or earth alkali metal hydroxide, alkoxide, amide, or hydride, substituted or unsubstituted ammonium hydroxide, or amine is added, and the resulting mixture or solution stirred and refluxed for some time. The solvent is evaporated and the product collected.
COMPOSITIONS The active compounds of this invention may be formulated into dilute compositions which make application to the plants easier and which permit easy penetration of the plant foliage. These compositions may be, in the case of the water soluble salts, simple aqueous solutions or they may be the defoliant compounds in combination with pesticidal carriers and/or surface active agents. Such compositions may be in the form of soluble or wettable powders, aqueous suspensions or dusts.
The surface-active agents or surfactants can include any of the anionic, cationic and non-ionic surface-active agents. A detailed list of such agents is set forth in Detergents and Emulsifiers 1967 Annual by John W. McCutcheon, Inc.
Among the more preferred surfactants are those anionic and non-ionic agents recognized in the art as wetting agents, dispersing agents, detergents or emulsifiers. Among the anionic surfactants, preferred ones are alkali metal or amine salts of alkylbenzenesulfonic acids such as dodecylbenzenesulfonic acid, alkali metal or amine salts of sulfated alcohols such as sodium lauryl sulfate, alkali metal or amine salts of alkynaphthalene sulfonates, sodium N-methyl-N-oleoyltaurate, oleic acid ester of sodium isethionate, dialkyl esters of sodium sulfosuccinic acid such as dioctyl sodium sulfosuccinate, and sodium dodecyldiphenyl oxide disulfonate. Among the non-ionic compounds, preferred members include alkylphenoxy poly(ethyleneoxy)ethanols such as nonylphenol adducts with ethylene oxide; trimethylnonyl polyethylene glycol ethers, polyethylene oxide adducts with fatty and rosin acids, ethylene oxide adducts with sorbitan fatty acid esters, and long chain alcohol or mercaptan adducts with ethylene oxide.
Among preferred surfactants are also dispersants such as methyl cellulose, polyvinyl alcohol, sodium lignin sulfonates, polymeric alkylnaphthalene sulfonates, and polymethylene bis sulfonates.
Surfactants can be present in compositions of this invention in the range of 0.1 to 20% by weight. However, in some instances, even greater proportions of surfac tants can be used.
A class of compositions particularly suitable for water-insoluble compounds of this invention are aqueous suspension concentrates such as the ones described in US. Patent 3,060,084 and in US. Patent 3,157,486. Aqueous suspension concentrates are very desirable because of their convenience in handling and use.
Additional compositions can be formulated by adding a free-flowing inert powder to the active agents. Such compositions can then be Wettable powders, water-soluble powders, or dusts.
Wettable powder compositions contain the active ingredient, one or more surfactants, and a finely divided inert diluent. The finely divided inert diluent can be any of the extenders commonly employed in the art. They can include natural clays including attapulgite or kaolinite, diatomaceous earth, pyrophyllite, talc, synthetic mineral fillers derived from silica and silicates such as synthetic fine silica and synthetic calcium or magnesium silicate, carbonates, phosphates and sulfates, sulfur, lime and flours such as wood, walnut shell, redwood, soybeans and cottonseed. Particle size of the extender can vary considerably but will ordinarily be somewhat under 50 microns in the finished formulation. The active compound ordinarily will be present in a concentration in the range of 25 to by weight. Surfactants will be present in a range from 0.1 to 10% by weight to obtain adequate wetting and dispersion in water, with the remainder being largely one or more of the finely divided diluents shown above.
Wettable powders are prepared by mixing the ingredients in a blender and grinding the mixture in a hammer mill, air impact mill or the like until the particle size has been reduced to make spray application practical and easy.
Wettable powders and aqueous suspension compositions are frequently used by dilution and extension with water to form spray slurry compositions containing from 0.05% to 3% of the active ingredient.
Preferred compositions of the water soluble compounds of this invention are the water soluble powders. These may be the active compound with water soluble neutral compounds and/or surfactants, or these compositions may be the active compounds in combination with alkaline water soluble salts to increase the solubility and/or the rate of solution of the active compounds. These compositions containing basic salts can of course also contain water soluble neutral compounds. Small amounts of anticaking agents can also be present in watersoluble compositions. Such anticaking agents may also be water-soluble, but more frequently will be chosen from the finely divided inert diluents, such as are used with Wettable powders. Usually the soluble powders will comprise 20 to active, 0-5% anticaking agent, 0-5% surfactant and the remainder a water-soluble base and/or a water-soluble diluent. Such compositions are prepared by blending and grinding the ingredients to obtain a homogeneous pulverulent mixture. If the ingredients are already in a sufficiently fine state of subdivision to make rapid dissolution practical, mere blending will usually be sufficient.
In addition, compositions may contain additives such as corrosion inhibitors, antifoam agents and the like.
Dusts are dense powder compositions which are intended for application in dry form. They are characterized by free-flowing, rapid settling properties, so that they are not readily wind-borne to areas where their presence is not desired. Dusts contain primarily the active compound and a dense, free-flowing solid extender. It is sometimes desirable to include a wetting agent, and convenience in manufacture frequently requires inclusion of an inert absorptive grinding aid.
The dense, free-flowing solid extenders usually are those organic or inorganic powders which possess high bulk density, are free-flowing, and have relatively low surface area and liquid adsorptivity. Suitable such extenders are micaceous talcs, pyrophyllite, dense kaolin clays, ground calcium phosphate rock (Phosphodust, American Agricultural Chemical Company), sericite, tobacco dust, etc.
The grinding aids and surface active agents can be the same as have been described for preparation of the wettable powders, above. In fact, wettable powders may be used in the preparation of dusts by dilution with the dense, free-flowing solid extender. While such wettable powders could be used directly in dust form, it is usually more advantageous to dilute them with these dense dust diluents in order to obtain more rapid settling and more uniform distribution. Similarly, the water-soluble powder composition can also be used in the preparation of dusts by dilution with the dense free-flowing solid extender.
Thus, the dust compositions of this invention will comprise about 330% active material, -3070 grinding aid, 03% surface active agent, the remainder being the extender. These dusts are prepared by blending the ingredients and grinding to obtain homogeneous pulverulent mixtures. If the ingredients are already finely divided, thorough blending will usually suffice for the preparation of a dust.
In order that the invention may be better understood, the following examples are given.
EXAMPLE 1 Preparation of [4-hydroxy-2-oxo-3-pyrroline-l-carboxanilide] 4-hydroxy-3-(3-phenylureid0)crotonic acid, gamma lactone One hundred and thirty six parts by weight of phenylurea and 165 parts by weight of ethyl 4-chloroacetoacetate are dispersed and dissolved in 200 parts by weight of p-dioxane. The mixture is boiled under reflux for 2 hours, cooled, and filtered. The solid is washed twice with methanol and once with diethylether. One hundred parts by weight of [4-hydroxy-2-oxo-3-pyrroline-l-carboxanilide] 4-hydr0xy-3-(3-phenylureido)crotonic acid, gamma lacrone is obtained, M.P. 250 C. dec.
EXAMPLE 2 Preparation of [4-hydroxy-3-methyl-2-oxo-3-pyrroline-lcarboxanilide] 2 methyl-4-hydr0xy-3-(phenylureido) crotonic acid, gamma lactone Thirty four parts by weight of phenylurea and 56 parts by weight of ethyl 4-bromo-2-methylacetoacetate are dispersed and dissolved respectively in 100 ml. of p-dioxane. The mixture is boiled under reflux for four hours, cooled, and filtered. The solid is washed twice with methanol and once with ether to yield 7 parts by weight [4-hydroxy- 3-methyl-2-oxo-3-pyrroline-l-carboxanilide], 2-methyl-4- hydroxy-3- (3-phenylureido) croronic acid, gamma lactone, M.P. 277 C. dec.
EXAMPLE 3 Preparation of [4-hydroxy-N-methyl-2-oxo-3-pyrroline-lcarboxanilide] 4-hydr0ry-3-(3-methyl-3-phenylureido) crotom'c acid, gamma lactone Thirty parts by weight of l-methyl-l-phenylurea and 41.8 parts by weight of ethyl 4-bromoacetoacetate are dissolved in 200 parts by weight of tetrahydrofuran, and the solution is boiled under reflux for three hours. The solvent is evaporated in vacuo and the residue redissolved in methylene chloride. This solution is extracted with aqueous sodium hydroxide solution and the latter subsequently acidified with hydrochloric acid. The precipitate is filtered, washed with water, and recrystallized from an ethanol-water mixture to yield 6 parts by weight of [4 hydroxy-N-methyl-2-oxo-3-pyrroline-1-carboxanilide] 4-hydr0xy-3-methyi-3-phenylureido)crotonic acid, gamma lactone, M.P. 197-198 C.
The following compounds are prepared in the same manner as described in Examples 1, 2 and 3 starting with the appropriately substituted 4-bromoor chloroacetoactic acid esters and areas:
[4-hydroxy-2-oxo-5-propy1-3-pyrroline-l-carboxanilide 3-ethyl-4-hydroxy-2-oxo-3-pyrroline-1-carboxanilide 5-ethyl-4-hydroxy-2-oxo-I i-pyrroline-l-earboxanilide 3,S-dimethyl-4-hydroxy-2-oxo-3-pyrrolinel-carboxanilide 3-fluoro-4-hydroxy-2-oxo-3-pyrrolinel-carboxanilide 4-hydroxy-2-oxo-N-propyl-3-pyrrolinel-carboxanilide 4-hydroxy-2-oxo-3-pyrroline-l-(N-ethylcarboxanilide) 3-methyl-4-hydroxy-2-oxo-3-pyrroline-l-(N-methylcarboxanilide) 4 -h ydroxy-4-propyi-3- 3-phen y lureido) crolon ic acid,
gamma lactone 2-ethyl-4-hydr0xy-3-(3-phenylureido)crotonic acid,
gamma lacrone 4-ethyl-4-hydraxy-3-(3-phenylureid0)crotonic acid,
gamma lacrane 2,4-dimerhyl-4-hydroxy-3-(phenylureida)crotonic acid,
gamma lactone 2-fluoro-4-hydroxy-3-(3-phenylureido) crotonic acid,
gamma lactone 4-hydr0xy-3-(3-propyl-3-phenyiureid0)crotonic acid,
gamma lactone 4-hydroxy-3-(3-ethyl-3-phenylureido)crotonic acid,
gamma lactone 2-methyi-4-hydroxy-3-(3-methyl-3-phenylureido)crotom'c acid, gamma lactone EXAMPLE 4 Preparation of [3-chloro-4-hydroxy-2-oxo-3-pyrroline-1- carboxanilide] 2-chlor0-4-hydr0xy-3-(3-phenylureido) crotonic acid, gamma lactone Twenty parts by weight of [4-hydroxy-2-oxo-3-pyrroline-l-carboxanilide] 4-hydr0xy-3-(3 phcnylureid0)cr0- tonic acid, gamma lactone is suspended in 200 parts by weight of glacial acetic acid. 12.2 parts by weight of sulfuryl chloride in 200 parts by weight of glacial acetic acid is added dropwise at room temperature with mechanical stirring. The mixture is stirred at room temperature for half an hour, filtered, the solid washed with water, and recrystallized from a dimethylformamide-water mixture to yield 13 parts by weight of [3-chloro-4-hydroxy-2-oxo- S-pyrroline 1 carboxanilide] 2-chi0r0-4-hydroxy-3-(3- phenylureid0)crot0nic acid, gamma lactone, M.P. 268 C. dec.
EXAMPLE 5 Preparation of [3-bromo-4-hydroxy-2-oxo-3-pyrroline-1- N-methylcarboxanilide] 2-br0mo-4-hydr0xy-3-(3-methyl-3-phenylureid )crotonic acid, gamma lactone Two parts by weight of [4-hydroxy-N-methy1-2-oxo-3- pyrroline 1 carboxanilide] 4-hydr0xy-3-(3-methyl-3- phenylureido)crotonic acid, gamma Iactone is suspended in 25 parts by weight of glacial acetic acid. 1.4 parts by Weight of bromine in 10 parts by weight of glacial acetic acid is added dropwise at room temperature under stirring. The mixture is stirred at room temperature for one hour. About 50 parts by weight of water is added slowly, and the mixture is filtered. The solid is washed thoroughly with water and methanol. Two parts by weight of [3-bromo-4-hydroxy-2-oxo-3-pyrroline-l-(N methylcarboxanilidefl 2-brom0-4-hydroxy-3-(3-methyl-3-phenylureido)crotonic acid, gamma lactone is obtained, M.P. 198 C. dec.
The following compounds are prepared as described in Examples 4 and 5, starting with the appropriately substituted [4 hydroxy-2-oxo-3-pyrroline-l-carboxanilideJ 4-hydroxy-3-(3-phcnylureido)crotonic acid, gamma lactone.
[3-bromo-4-hydroxy-2-oxo-5-propy1-3-pyrro1ine-1- carboxanilide 3-i0d0-4-hydroxy-2-oxo-3-pyrroline-l-carboxanilide 3-bromo-4-hydroxy-2-oxo-3-pyrroline-l-carboxanilide 3-bromo-4-hydroxy-N-isopropyl-2-oxo-3-pyrroline-lcarboxanilide 3-chloro-4hydroxy-N-methyl-2-oxo-3-pyrroline-1- carboxanilide 3-chloro-4-hydroxy-5-methyl-2-oxo-3-pyrroline-1- carboxanilide 3-bromo-4-hydroxy-2-oxo-3-pyrroline-1- (N-ethylcarboxauilide)] 2-bromo-4-hydroxy-4-propyl-3-(3-phenylureid0)crotonic acid, gamma lactone 2-i0do-4-hydroxy-3-(3-phenyiureido)crotonic acid,
gamma lactone 2-bromo-4-hydroxy-3-(3-phenylureido)crot nic acid,
gamma lactone 2-br0m0-4-hydr0xy-3-(3-isopropyl-3-phenylureido) crotonic acid, gamma lactone 2-chloro-4-hydroxy-3- (3-methyl-3-phenylureido)croto-nic acid, gamma lactone 2-chl0r0'4-hydroxy-4-methyl-3- (3-phenylureido) crotonic acid, gamma lactone 2-brom0-4-hydr0xy-3-(3-ethyl-3-phenylureido)crotonic acid, gamma lactone EXAMPLE 6 Preparation of the potassium salt of [4-hydroxy-2-oxo- 3-pyrroliue-l-carboxanilide] 4 hydroxy-3-(3-phenylureido)crotnic acid, gamma lactone Ten parts by weight of [4-hydroxy-2-oxo-3pyrroline-1- carboxanilide] 4-hydran -3-(3-phenyiureido)crotonic acid, gamma lactone and 3 parts by weight of 87.3% potassium hydroxide pellets are dispersed in 100 parts by weight of methanol. The mixture is boiled under reflux until a clear solution results. The solution is cooled and the methanol evaporated in vacuo. Benzene is added and evaporated in vacuo. The residue is collected and finely pulverized. Eleven parts by weight of the above potassium salt is obtained, M.P. 165 C. dec.
EXAMPLE 7 Preparation of the sodium salt of [3-bromo-4-hydroxy- 2-oxo-3-pyrroline-l-carboxanilide] 2-bram0-4-hydr0xy- 3-(3-phenylureido)crotonic acid, gamma lactone 2.5 parts by weight of [3-bromo-4-hydroxy-2-oxo-3- pyrroline-l-carboxanilide] 2-bromo-4-hydroxy-3-(3-phenylureido)crotonic acid, gamma lactone is suspended in 100 parts by weight of methanol. 1.5 parts by weight of sodium methoxide is added and the mixture is stirred. A clear solution results after about half an hour. The solvent is stripped in vacuo, and the solid residue collected and finely pulverized. Nine parts by weight of the above sodium salt is obtained, M.P. 190 C. dec.
The following compounds are prepared as described in Examples 6 and 7, starting with the appropriately sub stituted [4 hydroxy-2-oxo-3-pyrroline-l-carboxanilides] 4-hydr0xy-3-(3-phenylureido)crotonic acid, gamma lactone compounds and the appropriate base.
[4-hydroxy-2-oxo-3-pyrroline-l-carboxanilide, sodium,
potassium, and lithium salts a-hydroxy-Z-oxo-3-pyrroline-l-carboxanilide, magnesium, calcium, barium salts 3-chloro-4-hydroxy-2-oxo-3-pyrroline-l-carboxanilide,
sodium, potassium, lithium salts 3-bromo-4-hydroxy-2-oxo-3pyrroline-l-carboxanilide,
magnesium, calcium, barium salts 4-hydroxy-2-oxo-3-pyrroline-l-(N-methylcarboxanilide), ammonium salt 4hydroxy-2-oxo-3-pyrroline-1-(N-ethylcarboxanilide),
tetramethyl ammonium salt 4-hydroxy-2-oxo-3-pyrroline-1-(N-isopropylcarboxanilide), benzylamine salt 4-hydroxy-5-ethyl-2-oxo-3-pyrroline-1-carboxani1ide,
dipropylamine salt 4-hydroxy-S-ethyl-2-oxo-3-pyrroline- 1 -carboxanilide,
tert-butylamine salt 3 -fluoro-4-hydroxy-2- 0110-3 -pyrrolinel-carboxanilide,
sodium salt 4-hydroxy-3-methyl-2-oxo-3-pyrroline-l-carboxanilide,
calcium salt 3-chloro-4-hydroxy-2-oxo-3-pyrroline-1-(N-methylcarboxanilide), potassium salt 3-bromo-4-hydroxy-2-oxo-3-pyrroline-l-(N-propylcarboxanilide), sodium salt] 4-hydroxy-3-(S-phenylurcido)crotonic acid, gamma lactone, sodium, potassium, and lithium salts 4-hydroxy-3-(3-phenylureido)crotonic acid, gamma lactone, magnesium, calcium, barium salts 2-chloro-4-hydroxy-3-(3-phenyiureid0)crotonic acid, gamma lactone, sodium, potassium, lithium salts 2-br0mo-4-hydroxy-3-(3-phenylureido)crotonic acid, gamma lactone, magnesium, calcium, barium salts 4-hydr0xy-3-(3-methyl-3-phenylureido) crotonic acid,
gamma lactone, ammonium salt 4-hydroxy-3-(3-ethyI-3-phenylureido)crotonic acid,
gamma lactoae, tetramethyl ammonium salt 4-hydroxy-3-(3-is0pr0pyi3-phenylureido) crotonic acid,
gamma lactone. bcnzylamine salt 4-hydroxy-4-methyl-3- (phenylureidv) crotonic acid,
gamma iactone, dipropylamine salt 4-ethyl-4-hydroxy-3-(3-phenylureido)crotonic acid,
gamma lactone, tert-butylamine salt 2-flu0r0-4-hydroxy-3-(3-phenyiureid0)crotonic acid,
gamma lactone, sodium salt 2-mcthyl-4-hydr xy-3-(3-phenylureid0)cr0tonic acid,
gamma lactone, calcium salt 2-chlor0-4-hydroxy-3-(3-methyl-3-phenylureido crotonic acid, gamma lactone, potassium salt 2-bromo-4-hydroxy-3-(3-propyi-3-phenylureido)crotonic acid, gamma lactvne, sodium salt EXAMPLE 8 Preparation of [4-ethoxy-2-oxo 3-pyrroline l carbonanilide] 4 -h ydroxy-S (1 -ethyl-3-phen ylureido crotonic acid, gamma lactone Ten and nine-tenths parts by weight of [4-hydroxy-2- oxo-3-pyrroline-l-carboxanilide] 4-hydroxy-3-(3-phenylureid'o) crotonic acid, gamma lactone are suspended in parts by weight of methylene chloride. Nine and fivetenths parts by weight of triethyloxonium fluoroborate is added, and the mixture stirred at room temperature overnight. A clear solution results. Aqueous sodium bicarbonate solution is added and the two-phase system stirred at room temperature for one hour. A precipitate appears which is filtered off and recrystallized from ethanol.
With the appropriate Meerwein reagent, the following analogs may be synthesized:
[4-methoxy-2-oxo-3-pyrroline l-carboxanilide 4-isopropoxy-2-oxo-3-pyrro1ine- 1 -carboxanilide 1 l 4-butoxy-2-oxo-3-pyrroline-l-carboxanilide 3-bromo-4-methoxy-2-oxo-3-pyrroline-l-carboxanilide 3-chloro-4-methoxy-2-oxo-3-pyrro1ine-l-carboxanilide 3-bromo-4-ethoxy-2-oxo-3-pyrroline-l-carboxanilide] 4-hydroxy-3-(l-methyl-3-phenylureid0)crotonic acid,
gamma [actone 4-hydroxy-3-(I-isopropyl-St-phenylureid0) crotom'c acia,
gamma lactone 4 -h ydrxy-3- I -buty1-3-phenylureido croion ic acid,
gamma lactone 2-bromo-4-hydroxy-3-(I-methyl-3-phenylureido)crotonic acid, gamma lactone 2-chl0r0-4-hydroxy-3-(I-methyl-3-phenylureido)crotonic acid, gamma lactone 2-bromo-4-hydroxy-3-(I-ethyl-3-phenylureido)crotonic acid, gamma lacrone EXAMPLE 9 A water soluble powder formulation Percent [4 hydroxy 2 oxo 3 pyrroline 1 carboxanilide] 4-hydr0xy-3-(3-phenylureido)cr0t0nic acid,
gamma lactone, sodium salt 80.0 Dioctyl ester of sodium sulfosuccinic acid 2.5 Methyl cellulose 0.5 Trisodium phosphate dodecahydrate 17.0
The ingredients are combined in a ribbon blender and ground in a hammer mill to insure intimate mixing.
An 0.4% aqueous solution of the above composition is applied to mature cotton at the rate of one kilogram of the sodium salt of [4-hydroxy-2-oxo-3-pyrroline-l-carboxanilide] 4-hydroxy 3 (3-phenylureido)crotonic acid, gamma lactone per hectare. The application is made utilizing ground equipment. As a result of this treatment abscission of the cotton leaves is obtained within one week after application of the chemical, thereby allowing all of the cotton bolls, from the lower portions of the plants to their tops, to mature uniformly and facilitating subsequent mechanical harvesting. Subsequent regrowth is retarded. The cotton produces a good yield of stainfree, high-quality lint.
An aqueous solution containing 3 kilograms of the sodium salt of [4-hydroxy-2-oxo-3-pyrroline-l-carboxanilide] 4-hydroxy-3-(3-phenylureido)crotonic acid, gamma lactone in 400 l. of water is prepared and sprayed uniformly over a hectare of bluegrass turf after the second morning in the spring. The treatment retards the growth of the grass through the spring and markedly reduces the number of mowings necessary to maintain the neat appearance of the turf compared to similar untreated areas.
EXAMPLE A water soluble powder formulation Percent [4 hydroxy 2 oxo 3 pyrroline l carboxanilide] 4-hydroxy-3-(3-phenylureido)crotonic acid, gamma iactonc 95.0
Sodium alkyl naphthalene sulfonate 2.0
Sodium salt of a partially desulfonated lignin sultonate 2.0
Synthetic fine silica 3.0
position on the plants. The subsequently harvested crop is of higher quality than soybeans harvested from a neighboring untreated field.
EXAMPLE 11 A wettable powder formulation Percent [3 chloro 4 hydroxy 2 oxo 3 pyrroline 1- carboxanilide] 2 chI0r04-hydr0xy-3-(3-phenyiureid0)crotonic acid, gamma lactone 50.0 Sodium lauryl sulfate 0.5 Calcium lignin sulfonate 2.0
The ingredients are combined in a ribbon blender and ground in a hammer mill until the particle size is essentially less than 50 microns in diameter.
The composition described above is dispersed in water to a concentration of 0.15%, based on the weight of [3 chloro 4 hydroxy 2 oxo 3 pyrroline 1- carboxanilide] 2-chloro 4 hydran -3-(3-p-henylureido) crotonic acid, gamma lactone. To this suspension is added the S,S,S-tributyl ester of phosphorotrithious acid in the form of an emulsifiable concentrate (commercially available under the trademark Folex) in an amount sufficient to raise the total content of active ingredients in the suspension to 0.3%. The accordingly prepared suspension is applied by ground sprayer to a field of cotton which is approaching maturity. The rate of application is 0.5 kg./ hectare of each of the two active ingredients. The treatment results in substantially complete defoliation and/or desiccation of the leaves of the cotton plants. The devel opment of new leaves is retarded. No difficulties are encountered in harvesting the treated field by machine. The harvested bolls contain significantly less trash than those from an untreated control strip.
EXAMPLE 12 An aqueous suspension formulation Kaolin clay Percent [3 bromo 4 hydroxy 2 oxo 3 pyrrolidinel-carboxanilide] 2-bromo-4-hydraxy-3-(3-phenyl- All of the ingredients are blended together and ground in a sand mill until the particles are essentially less than 10 microns in diameter.
This composition is suspended in water to give an aqueous dispersion containing 0.2% of the substituted [pyrroline-carboxanilide] 4-hydrotx-y-3-(3-phenylureido) crotonic acid, gamma lacrone compound. The spray composition is applied to a maturing field of tomato plants, utilizing 0.65 kg./hectare of active ingredient, and causes most of the leaves to drop within eight days after treatment. The fruit of the defoliated plants ripens more easily 351d is less subject to disease than the fruit from control p ots.
EXAMPLE 13 The formulation is prepared by blending the ingredients in a ribbon blender or similar device and grinding the mixture in a hammer mill to insure intimate mixing.
The above composition is extended with water to a concentration of 0.35% of the sodium salt. A volume of 250 liters of this freshly prepared solution is uniformly applied to a maturing field of seed alfalfa causing abcissions of most of the leaves. The absence of succulent foliage permits direct combining of seed from the treated field.
Eight kilograms of this composition are dissolved in 500 l. of water and applied to runoff on a freshly trimmed and growing mixed brush stand under a power line. The treatment retards the growth of the brush and lengthens the interval before another trimming is necessary.
EXAMPLE 14 A water soluble salt formulation Percent [4 hydroxy 2 oxo 3 pyrroline 1 carboxanilide] 4-hydr0xy 3 (3-phenyl'ureido) crotonic acid, gamma lactane, lithium salt 50.0 Sodium lauryl sulfate 0.5 Sodium meta-silicate, anhydrous 23.5 Potassium carbonate 26.0
The formulation is prepared by blending the ingredients and grinding in a hammer mill to insure intimate mixing.
The above composition is extended with water to give an ultimate concentration of 1.2% of the lithium salt of the substituted pyrrolidine carboxanilide compound. This liquid spray composition is applied in a volume of 300 l./hectare to a field of cotton which is at the stage of development where the first bolls are open. After six to eight days most of the leaves fall to the ground while still green. The field matures much more uniformly than an adjacent untreated field and is readily harvested by mechanical means.
EXAMPLE 15 A dust formulation Percent [3 chloro 4 hydroxy 2 oxo 3 pyrrolidinel-carboxanilide] 2-chl0r0-4-hydroxy-3- (3-phenylureido) crotonic acid, gamma lactone Calcium silicate 10 Calcium carbonate coated with calcium stearate 80 The active ingredient and the calcium silicate are blended together and ground in a hammer mill. This intimate mix is then charged to a ribbon blender along with the coated calcium carbonate. The mixture is thoroughly blended to insure uniform distribution of the active ingredient throughout the dust.
The above dust composition is applied to a maturing cotton field in the early morning when the plants are wet from dew at the rate of 30 kg./hectare and causes almost complete defoliation of the crop plants. The defoliated area is harvested by machine and yields a highly satisfactory crop of stainfree and trashfree lint.
EXAMPLE 16 A wettable powder formulation Percent [4-ethoxy 2 oxo-3-pyrroline-l-carboxanilide] 4-hydroxy 3 (1 ethyl-3-phenylureid0)crotonic acid,
gamma laczone 30 Sodium alkylnaphthalenesulfonate 2 Sodium lignin sulfonate 2 Attapulgite 66 The ingredients are blended, passed through an air mill until the average particle size is microns, reblended, sifted through a USS #50 sieve (0.3 mm. opening), and packaged.
This formulation is applied to mature cotton approximately ten days before harvest at the rate of 2 kg./ha. (active ingredient) suspended in 250 liters of Water. The treatment provides good defoliation of the cotton, and facilitates mechanical harvesting of the cotton fibers.
14 EXAMPLE 17 A wettable powder formulation Percent [3-bromo-4-hydroxy 2 oxo-3-pyrroline-l-carboxanilide] 2 bromo 4-hydr0xy-3-(3-phenylureido) crotonic acid, gamma lacron-e 70.0
Sodium alkyl naphthalene sulfonate 2.0 Sodium salt of partially disulfonated lignin sulfonate 3.0
Attapulgite clay 25.0
All of the ingredients are blended together in a ribbon blender or similar device. Following this the mixture is ground in a hammer mill until the particle size is substantially less than 50 microns in diameter.
The above-described composition is dispersed in water and applied by air to a maturing field of cotton at a rate of 10 kg. of [pyrroline carboxanilide] 2-br0mo-4-hydroxy-3-(3-phenylureid0) crotonic acid, gamma lacrone compound per hectare. The spray volume is 45 liters per hectare. Soon after treatment the sprayed plants shed most of their leaves thereby permitting the bolls to mature. At full maturity [of] the crop is harvested by machine, yielding a large volume of high-quality lint.
All of the compounds of this invention can be formulated and applied in the same manner as Example 17, with similar results.
UTILITY The compounds of the present invention at rates of 0.25 to 30 kg. per hectare are useful for the defoliation of a large variety of plants, thereby aiding maturation and/or facilitating the harvesting operation. Among the crops which benefit from the application of the harvest aids in accordance with the invention are cotton, legume and grass seed crops, soybeans, kidney beans and other beans, tomatoes, etc. These compounds are also useful for the retardation of the growth of grasses and brush. On many species including Kentucky bluegrass, prinet and forsythia they cause retardation of growth with little plant injury. On other species, such as orchard grass and black willow they cause injury in addition to retardation. By selection of the proper species, rate and time of application, these compounds may be used to retard the growth of plants and, thereby, reduce the labor required to maintain them at a desirable size. This retardant effect is also useful in the prevention of regrowth of defoliated plants. The compounds of the invention may be applied in liquid or dry compositions either by themselves or mixed with other harvest aids which are commonly known in the art, such as the S,S,S-tributyl ester of phosphorotrithious acid, pentachlorophenol, sodium or magnesium chlorate, calcium cyanamid, ammonium nitrate, arsenic acids and others.
What is claimed is:
1. A compound of the formula O lit:
R1 R5 0 R5 where:
through four carbon atoms or benzyl and y is 0 to 3.
2. A compound as in claim 1 Where R is hydrogen or chlorine, R, is methyl, R is hydrogen and salts of said compound with lithium ions, sodium ions and potassium 3. A compound as in claim 1 having the formula [4- hydroxy-Z-oxo-3-pyrroline-l-carboxanilide] 4-hydroxy-3- (3-phenylureido)croronic acid, gamma lactone.
4. The sodium salt of the compound of claim 3.
5. The lithium salt of the compound of claim 3.
6. A compound as in claim 1 having the formula [3- chloro 4 hydroxy-2-oxo-3-pyrroline-l-carboxanilide] 2- chloro 4 hydroxy 3 (3-phenylureid0)crotonic acid, gamma lactone.
7. The sodium salt of the compound of claim 6.
8. The potassium salt of the compound of claim 6.
References Cited 4/1971 Bachman 260343.6
OTHER REFERENCES Wiley: Chem. Abs., vol. 44: 1062e (1950).
ALEX MAZEL, Primary Examiner A. M. T. TIGHE, Assistant Examiner US. Cl. X.R.
US27894D 1972-05-15 1972-05-15 Hydroxy-j-(j-phenylureido)crotonic acid, gamma lactone compounds Expired USRE27894E (en)

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3969370A (en) * 1974-04-17 1976-07-13 E. I. Du Pont De Nemours And Company 1-Tertiary-alkyl-3-(substituted furyl)ureas as antihypertensive agents
EP0423482A1 (en) * 1989-09-23 1991-04-24 Bayer Ag 5H-furan-2-one derivatives
US5207817A (en) * 1989-09-23 1993-05-04 Bayer Aktiengesellschaft Herbicidal 5H-furan-2-one derivatives
WO1999012917A1 (en) * 1997-09-05 1999-03-18 Roche Diagnostics Gmbh Ureido and thioureido derivatives of 4-amino-2(5h)-furanones and 4-amino-2(5h)-thiophenones as antitumor agents

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3969370A (en) * 1974-04-17 1976-07-13 E. I. Du Pont De Nemours And Company 1-Tertiary-alkyl-3-(substituted furyl)ureas as antihypertensive agents
EP0423482A1 (en) * 1989-09-23 1991-04-24 Bayer Ag 5H-furan-2-one derivatives
US5094681A (en) * 1989-09-23 1992-03-10 Bayer Aktiengesellschaft Herbicidal 5h-furan-2-one derivatives
US5207817A (en) * 1989-09-23 1993-05-04 Bayer Aktiengesellschaft Herbicidal 5H-furan-2-one derivatives
WO1999012917A1 (en) * 1997-09-05 1999-03-18 Roche Diagnostics Gmbh Ureido and thioureido derivatives of 4-amino-2(5h)-furanones and 4-amino-2(5h)-thiophenones as antitumor agents
US6333346B1 (en) 1997-09-05 2001-12-25 Roche Diagnostics Gmbh Ureido and thioureido derivatives of 4-amino-2(5H)-furanones and 4-amino-2(5H)-thiophenones as antitumor agents

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