Classifications

• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
  • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
  • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
  • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
  • A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
• • A61K47/48184—
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K31/00—Medicinal preparations containing organic active ingredients
  • A61K31/13—Amines
  • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
  • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K31/00—Medicinal preparations containing organic active ingredients
  • A61K31/13—Amines
  • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
  • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K31/00—Medicinal preparations containing organic active ingredients
  • A61K31/33—Heterocyclic compounds
  • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
  • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
  • A61K31/47—Quinolines; Isoquinolines
  • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
  • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
  • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
  • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
  • A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
  • A61K47/585—Ion exchange resins, e.g. polystyrene sulfonic acid resin
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K9/00—Medicinal preparations characterised by special physical form
  • A61K9/20—Pills, tablets, discs, rods
  • A61K9/2004—Excipients; Inactive ingredients
  • A61K9/2009—Inorganic compounds
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K9/00—Medicinal preparations characterised by special physical form
  • A61K9/20—Pills, tablets, discs, rods
  • A61K9/2004—Excipients; Inactive ingredients
  • A61K9/2022—Organic macromolecular compounds
  • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K9/00—Medicinal preparations characterised by special physical form
  • A61K9/20—Pills, tablets, discs, rods
  • A61K9/2004—Excipients; Inactive ingredients
  • A61K9/2022—Organic macromolecular compounds
  • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
  • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K9/00—Medicinal preparations characterised by special physical form
  • A61K9/20—Pills, tablets, discs, rods
  • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
  • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
• • B—PERFORMING OPERATIONS; TRANSPORTING
  • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
  • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
  • B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders

Definitions

• the present invention relates to an improved pharmaceutical dosage form. More particularly, the invention relates to a tamper-resistant dosage form including a therapeutic agent-substrate complex, a thermoplastic polymer, and optionally, one or more pharmaceutical additives, and the method of making same.
• Product tampering occurs when a dosage form is manipulated to achieve an objective in ways that is not intended per dosing instructions. It may involve drug abusers who tamper the dosage form to obtain euphoria, or non-abusers such as patients and caregivers who innocently tamper with the dosage form to address legitimate concerns. For example, an elderly patient may break a dosage form to facilitate swallowing or a caregiver may break a dosage form to reduce the therapeutic dose.
• Abuse deterrent formulations are designed to thwart deliberate attempts by drug-abusers to extract the active ingredient or blunt the euphoric effects from unapproved methods of administration.
• Common methods of drug abuse include: (1) oral ingestion, where the dosage form is chewed, crushed, milled or ground and swallowed, with or without co-ingestion of alcohol, to destroy the release controlling matrix and deliver high doses of therapeutic agent into the gastrointestinal tract; (2) intravenous injection, which involves extraction of the therapeutic agent from the dosage form using an appropriate solvent, followed by injection of the therapeutic agent directly into the blood stream; (3) nasal snorting, where the dosage form is crushed, milled, or ground into a fine powder and administered intra-nasally to facilitate rapid drug absorption through the lining of the nasal passages; and (4) smoking, where the therapeutic agent is vaporized for inhalation by subjecting the dosage form to heat.
• dosage forms are relatively large in size and may pose a dosing challenge to many people including the elderly and young. Often, patients and caregivers may break the dosage form to reduce the size. By doing so, they inadvertently compromise the release controlling mechanism of the dosage form and potentially lead to dose dumping, often with adverse consequences.
• U.S. Pat. No. 7,510,726 describes a therapeutic pharmaceutical composition comprising a mixture consisting of at least one opioid analgesic, gel forming polyethylene oxide, and at least one disintegrant.
• U.S. Pat. No. 7,771,707 describes a solid abuse deterrent pharmaceutical composition of a pharmaceutically active agent prone to abuse, and one or more fatty acids or fatty amines present in molar excess relative to the pharmaceutically active agent.
• U.S. Pat. No. 7,776,314 describes parenteral abuse-proofed solid dosage form for oral administration, comprising one or more active ingredients with potential for abuse, and at least one viscosity-increasing agent.
• U.S. Pat. No. 8,075,872 describes an abuse resistant dosage form thermoformed by extrusion and having a breaking strength of at least 500 N, which contains a mixture of one or more active ingredients with abuse potential, polyalkylene oxides, physiologically acceptable auxiliary substances, and optionally wax and cellulosic derivatives.
• U.S. Pat. No. 8,409,616 describes a therapeutic pharmaceutical composition comprising a water-soluble drug susceptible to abuse, a gel forming polymer and a disintegrant.
• U.S. Pat. No. 8,449,909 describes a therapeutically effective pharmaceutical composition
• a therapeutically effective pharmaceutical composition comprising solid microparticles, wherein the microparticles comprise an active agent, one or more fatty acids, and one or more carrier materials selected from waxes or wax-like substances.
• U.S. Patent Application Publication 2008/0075770 describes a monolithic solidified oral dosage form prepared by a thermal process comprising a therapeutic agent and a hydrophilic polymer.
• U.S. Pat. No. 8,486,448 describes a controlled release formulation comprising a core comprising a superabsorbent material, a controlled release coat surrounding the core; and a plurality of controlled release microparticles containing a pharmaceutically active agent.
• U.S. Patent Application Publication 2011/0020451 describes a tamper-resistant thermoformed pharmaceutical dosage form having a breaking strength of at least 300 N and comprising an opioid, a physiologically acceptable acid and a polyalkylene oxide.
• U.S. Patent Application Publication 2012/0148672 describes a coated modified release opioid-ion exchange resin complex comprising a pharmaceutically effective amount of an opioid bound to a pharmaceutically acceptable ion exchange resin complex; and a pH-independent, high tensile strength, water permeable, water insoluble, diffusion barrier coating.
• the present invention is related to a tamper-resistant dosage form that includes at least one therapeutic agent; at least one substrate; and at least one thermoplastic polymer, such that the at least one therapeutic agent and the at least one substrate form a therapeutic agent-substrate complex, the at least one thermoplastic polymer and optionally at least one pharmaceutical additive form a thermo-formable matrix, and the therapeutic agent-substrate complex is embedded in the thermo-formable matrix.
• the present invention is related to a process of preparing a tamper-resistant dosage form, including the steps of: (1) blending at least one therapeutic agent and at least one substrate in a therapeutic agent-to-substrate ratio between 1:10 to 10:1; (2) reacting the at least one therapeutic agent and the at least one substrate to form a therapeutic agent-substrate complex; (3) forming a thermo-formable matrix blend with at least one thermoplastic polymer and optionally at least one pharmaceutical additive; (4) mixing the therapeutic agent-substrate complex and the thermo-formable matrix blend in a ratio between 1:20 to 20:1; (5) granulating the therapeutic agent-substrate complex and the thermo-formable matrix blend to form the tamper-resistant dosage form in which the therapeutic agent-substrate complex is embedded in the thermo-formable matrix; and (6) shaping the tamper-resistant dosage form into one of an immediate release or modified release tablet form and an immediate release or modified release multiparticulate form.
• An embodiment of the invention is a tamper-resistant dosage form that is resistant to various tampering modes.
• the tamper-resistant dosage form includes at least one drug, at least one substrate and at least one thermoplastic polymer and optionally at least one pharmaceutical additive that are arranged in the following manner: the at least one drug and the at least one substrate form a drug-substrate complex, the at least one thermoplastic polymer and optionally the at least one pharmaceutical additive form a thermo-formable matrix, and the drug-substrate complex is dispersed and embedded in the thermo-formable matrix.
• thermo-formable matrix It has been discovered that a therapeutic agent-substrate complex embedded into a thermo-formable matrix is effective against all forms of product tampering and drug abuse without the use of aversion agents and antagonists. It is critical that a complex of the therapeutic agent and a substrate is formed first prior to incorporation into the thermo-formable matrix in order for the formulation to provide tamper-resistance.
• thermo-formable matrix As illustrated in Example 2; if the therapeutic agent is dispersed in the thermo-formable matrix without a substrate as illustrated in Example 3; or if only a blend of the therapeutic agent and the substrate but not a complex is dispersed in the thermo-formable matrix as illustrated in Example 4, then these formulations do not provide tamper-resistant formulations.
• a “therapeutic agent” means a “drug” substance that elicits a pharmacologic response when administered by a patient or drug abuser.
• “therapeutic agent” and “drug” are used interchangeably.
• “Substrate” means a substance that interacts with the therapeutic agent to form a complex. Such a substrate could be a polyelectrolyte, an organic counter-ion, an inclusion compound, a pharmacologically inert organic component of a prodrug or an inorganic adsorbent.
• “Complex” means a chemical association of a drug substance with a substrate through ionic bonds, covalent bonds, polar covalent bonds, and hydrogen bonds.
• the “thermo-formable matrix” comprises one or more thermoplastic polymers, and optionally one or more pharmaceutical additives that improve functionality and processability of the dosage forms.
• the thermo-formable matrix imparts plasticity and hardness to the dosage form. Embedding the drug-substrate complex in the thermo-formable matrix produces a synergistic effect that renders the dosage form more resistant to tampering.
• a “thermoplastic” polymer is a polymer that is solid at room temperature, and becomes pliable and moldable at elevated temperatures.
• a critical property of thermoplastic polymers is the glass transition temperature, a temperature where the polymer changes or transitions from a solid glassy phase into a rubbery phase. Glass transition temperatures are lowered by incorporating plasticizers.
• “tampering” means an intentional or an unintentional manipulation of dosage forms in a manner that is not intended for by dosing instructions, such as chewing, crushing, breaking, grinding, extraction and volatilization.
• the dosage form in the invention does not break when a substantial force is applied. Milling or grinding the dosage form into fine powder using conventional methods, such as mortar and pestle or a hammer mill is impossible. Hardness measurement using standard hardness testers is not applicable.
• the dosage form according to the invention is, therefore, resistant to tampering by breaking, crushing, grinding and chewing.
• thermoplastic matrix generates a gel layer on the surface of the dosage form and limits liquid penetration into the core of the dosage form, which, in turn, limits the mobility of the therapeutic agent-substrate complex and hence the mobility of the therapeutic agent within the dosage form.
• the therapeutic agent-substrate complex present at the gel layer keeps the therapeutic agent tightly bound to the complex and does not make it available for extraction.
• the gel forming properties of the thermo-formable matrix and the embedded therapeutic agent-substrate complex provide a high degree of tamper resistance to extraction.
• Abusers often heat the dosage forms to vaporize the drug for smoking purposes.
• the dosage form according to the invention prevents vaporization by immobilizing the therapeutic agent within the therapeutic agent-substrate complex, and immobilizing the therapeutic agent-substrate complex within the theremo-formable matrix.
• the therapeutic agent-substrate complex has much lower vapor pressure than that of the free drug and as a result, requires much higher heat energy to liberate the free drug from the complex.
• the matrix prevents drug mobility and limits drug diffusion and vaporization through and out of the dosage form upon exposure to heat. Excessive heating of the dosage form with the intention of drug vaporization leads to decomposition and charring of formulation components which in turn may liberate obnoxious fumes that the abuser may not tolerate.
• a “therapeutic agent” means a “drug” substance that elicits a pharmacologic response when administered by a patient or drug abuser.
• “Therapeutic agent” and “drug” are used interchangeably.
• Therapeutic agents covered by the present invention include those that are susceptible to abuse, i.e. “abuse-prone”, and those that are not.
• the invention relates to an abuse-prone therapeutic agent that includes, but not limited to, narcotic opioids, CNS depressants, sedatives/hypnotics, stimulants, and decongestants.
• narcotic opioids include, but not limited to, alfenatil, allylprodine, alphaprodine, anileridine, apomorphine, apocodeine, benzylmorphine, benzitramide, buprenorphine, butorphanol, clonitrazene, codeine, codeine methylbromide, codeine phosphate, codeine sulfate, cyclazocine, cyclorphen, cyprenorphine, desmorphine, dextromethorphan, dextromoramide, dezocine, diamromide, dihydrocodeine, dihydrocodeinone, dihydromorphine, dimenoxadol, dimepheptanol, dimethylthiambutene, dioxyaphetyl butyrate, dipipanone, eptazocine, ethoheptazine, ethylmethylthiambutene, ethylmorphine, eton
• CNS depressants examples include, but not limited to, acecabromal, bomisovalum, capruide, cabromal, ectylurea, chlorhexadol, ethcholorvynol, meparfynol, 4-methyl-5-thiazolethanol, tetrapentylalcohol, butoctamide, diethylbromoacetamide, ibrotamide, isovarleryl diethylamide, niaprazine, triacetamide, trimetozine, zolpidem, zopiclone; barbituric acid derivatives such as allobarbital, amobarbital, aprobarbital, barbital, brallabarbital, butabarbital sodium, butabarbital, butallylonal, buthetal, carbubarb, cyclobarbital, cyclopentobarbital, enallylpropymal,
• stimulants include, but not limited to, amphethamine, dextroamphethamine, levoamphetamine, methamphetamine, methylphenidate, phenmetrazine, modatinil, avafinil, armodafinil, and ampalimes; cannabinoids such as tetrahydro-cannabinol, nabilone; ketamine, tiletamine, dextromethorphan, ibogaine, dixocilpine; anabolic steroids such as androisoxazole, androstenediol, bolandiiol, clostebol, ethylesternol, formyldienolone, 4-hydroxy-19-nortestosterone, methandriol, methenolone, methyltrienolone, nandrolone, nandrolone deconate, nandrolone p-hexyloxyphenylpropionate, nandrolone phenpropionate, norbol
• decongestants include, but not limited to, pseudoephedrine, ephedrine, levo-methamphetamine, phenylpropanolamine, propylhexedrine and synephrine, and mixtures thereof.
• the invention relates to a therapeutic agent that is not susceptible to abuse, such as, but not limited to, atenolol, albendazole, alendronate, alprostadil, allopurinol, amlexanox, anagrelide, aminophylline, alitretinoin, amodiaquine, astemizole, atovaquone, aztreonam, atorvastatin, azlocillin, baclofen, benazepril, benzonatate, bitolterol mesylate, brompheniramine, cabergoline, carisoprodol, celecoxib, cefpiramide, chlorothiazide, chlormezanone, cimetidine, cetirizine, cefotaxime, ciprofloxacin, cephalexin, chloroquine, clomocycline, cyclobenzaprine, cyproheptadine, cyprohept
• thermoplastic polymers such as, but not limited to, cellulose derivatives, vinyl derivatives, acrylates, polyoxides, polysaccarides and polyglycols.
• a “thermoplastic” polymer is a polymer that is solid at room temperature, and becomes pliable and moldable at elevated temperatures.
• a critical property of thermoplastic polymers is the glass transition temperature, a temperature where the polymer changes or transitions from a solid glassy phase into a rubbery phase. Glass transition temperatures are lowered by incorporating plasticizers.
• thermoplastic polymers suitable for the present invention include, but not limited to, hydroxypropyl cellulose, hydroxylpropyl methyl cellulose, methyl cellulose, methylmethacrylate, carrageenan, xanthan gum, polyethylene glycol, polyethylene oxide, polypropylene glycol, polyvinyl acetate, polyvinyl alcohol, polyvinyl pyrrolidone, butyl/methylmethacrylate-dimethylaminoethylmethacrylate copolymer, polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol, and hydroxylethyl cellulose, and mixtures thereof.
• the invention relates to a tamper-resistant dosage form comprising one or more substrates such as polyelectrolytes, inorganic adsorbents, organic acids, inclusion compounds, fatty acids and pharmacologically inert components of prodrugs.
• a “substrate” is a substance that interacts with a therapeutic agent to form a complex.
• “Complex” means a chemical association between a therapeutic agent and a substrate through ionic bonds, covalent bonds, polar covalent bonds, and hydrogen bonds.
• substrates comprise polyelectrolytes consisting of natural polyelectrolytes selected, for example, from the group consisting of nucleic acids, poly(L-lysine), poly(L-glutamic acid), carrageenan, alginates, and hyaluronic acid, and mixtures thereof; chemically modified polyelectrolyte selected, for example, from the group consisting of pectin, chitosan (deacetylation of chitin), cellulose-based, starch-based and dextran-based polymers and mixtures thereof; and synthetic polyelectrolytes selected from, for example, poly(vinylbenzyl trialkyl ammonium), poly(4-vinyl-N-alkyl-pyridimiun), poly(acryloyl-oxyalkyl-trialkyl ammonium), poly(acryamido-alkyl-trialkyl ammonium), poly(diallydimethyl-ammonium), poly(acrylic or methacrylic
• ion exchange resins include sulfonated copolymer of styrene and divinylbenzene, a carboxylate copolymer of styrene and divinylbenzene, a copolymer of styrene and divinylbenzene containing quaternary ammonium groups such as Amberlite® IR-120(sodium salt of styrene divinylbenzene sulfonate copolymer), Amberlite® XE-69 (sodium salt of styrene divinylbenzene sulfonate copolymer), Amberlite® IRP-64 (methacrylic acid divinylbenzene carboxylate copolymer), Amberlite® IRP-69 (sodium salt of styrene divinylbenzene sulfonate copolymer), Dowex® 50WX2 (sulfonate of styrene and divinylbenzene copo
• substrates comprise inorganic adsorbents selected, for example, from the group consisting of but not limited to aluminum silicate, attapulgite, bentonite, calcium silicate, kaolin, lithium magnesium aluminum silicate, lithium magnesium silicate, lithium magnesium sodium silicate, magnesium silicate, magnesium trisilicate, montmorillonite, pyrophyllite, sodium magnesium silicate, zeolite, and zirconium silicate and mixtures thereof.
• substrates comprise inclusion compounds selected, for example, from the group consisting of but not limited to ⁇ -cyclodextrins, ⁇ -cyclodextrins and ⁇ -cyclodextrins.
• substrates comprise organic acids selected, for example, from the group consisting of but not limited to acetates, besylates, tartrates, citrates, maleates, succinates, fumarates, adipiates, and oxalates and mixtures thereof.
• substrates comprise fatty acids selected from the group, for example, consisting of but not limited to arachidonic acid, capric acid, caprylic acid, dihomo- ⁇ -linoleic acid, docesenoic acid, docosatetraenoic acid, docosohexaconic acid, docosopentanoic acid, eicosapentanoic acid, gondoic acid, lauric acid, linoleic acid, ⁇ -linoleic acid, 6-linoleic acid, myristic acid, nervonic acid, oleic acid, oleostearic acid, palmitic acid, palmitoleic acid, stearic acid, and vaccenic acid and mixtures thereof.
• fatty acids selected from the group, for example, consisting of but not limited to arachidonic acid, capric acid, caprylic acid, dihomo- ⁇ -linoleic acid, docesenoic acid, docosatetraenoic
• substrates comprise pharmacologically-inert organic component of prodrugs is selected, for example, from the group consisting of but not limited to amides and esters.
• the invention relates to a dosage form optionally comprising pharmaceutical additives that improve functionality and processability of dosage forms.
• Pharmaceutical additives that are incorporated in formulations consist of plasticizers, waxes, surfactants, inorganic fillers, anti-adherents, erosion enhancers, anti-oxidants, and buffering agents.
• plasticizers include, but not limited to, dibutyl sebacate, glycerol, polyethylene glycol, propylene glycol, triacetin, tributyl citrate, and triethyl citrate and mixtures thereof.
• waxes include, but not limited to, bees wax, candilila wax, carnuba wax, and paraffin wax and mixtures thereof.
• surfactants include, but not limited to, alkyl benzene sulfones, alkyl sulfates, ether carboxylates, glycerol/propylene glycol fatty acid esters, hexadecyl triammonium bromide, hydroxylated lecithin, lauryl carnitine, lower alcohol-fatty acid esters, mono-/di-glycerides, Ovothin® (phospholipid extracted from egg), polyethylene glycol alkyl ethers, polyethylene glycol-fatty acid monoesters, polyethylene glycol-fatty acid diesters, polyethylene glycol-glycerol esters, polyethylene glycol phenols, polyethylene glycol-sorbitan fatty acid esters, polyglyceride fatty acids, polyoxyethylene-polyoxypropylene block copolymers, propylene glycol-fatty acid esters, sodium cholate, sodium lauryl sulfate, sodium palmitate, sodium taurocholate, sorbitan
• inorganic fillers include, but not limited to silicon dioxide, aluminum silicate, attapulgite, bentonite, calcium silicate, calcium carbonate, dicalcium phosphate, kaolin, lithium magnesium aluminum silicate, lithium magnesium silicate, lithium magnesium sodium silicate, magnesium silicate, magnesium trisilicate, montmorillonite, pyrophyllite, sodium magnesium silicate, talc, titanium dioxide, zeolite, and zirconium silicate, and mixtures thereof.
• anti-adherents include, but not limited to, calcium carbonate, dicalcium phosphate, kaolin, talc, and titanium dioxide, and mixtures thereof.
• erosion enhancers include, but not limited to, low molecular weight water soluble polymers such as hydroxyethyl cellulose, hydroxypropyl methyl cellulose, and polyvinyl pyrrolidone; polyols, such as mannitol, malitol, sorbitol, and xylytol, and surface active agents such as sodium lauryl sulfate, and Polysorbate 80, and mixtures thereof.
• low molecular weight water soluble polymers such as hydroxyethyl cellulose, hydroxypropyl methyl cellulose, and polyvinyl pyrrolidone
• polyols such as mannitol, malitol, sorbitol, and xylytol
• surface active agents such as sodium lauryl sulfate, and Polysorbate 80, and mixtures thereof.
• antioxidants include, but not limited to, butylhydroxytoulene, butylhydroxyanisole, propyl gallate, ascorbic acid and vitamin E-TPGS, and mixtures thereof.
• buffering agents include, but not limited to, phosphates, citrates, acetates, oxides and carbonates, and mixtures thereof.
• the invention relates to monolithic and multiparticulate dosage form comprising a therapeutic agent-substrate complex, one or more thermoplastic polymers, and one or more pharmaceutical additives.
• the tamper-resistant dosage form of the present invention can be prepared according to the steps of:
• thermo-formable matrix blend with at least one thermoplastic polymer and optionally a pharmaceutical additive
• the reacting step of (2) can be carried out by a reactive extrusion process.
• the granulating step of (5) can be carried out by a hot melt extrusion process, or optionally by a wet granulation or a dry granulation process.
• the therapeutic agent-substrate complex is prepared using a novel reactive extrusion process.
• the reactive extrusion process is fast and continuous compared to other commonly used processes. It allows the complexation process to proceed at a faster rate by providing flexibility in reaction temperatures and online incorporation of pH modifiers and other additives that promote complex formation.
• the extruder which behaves as a reactor, is preferably a twin screw extruder. It comprises uniquely assembled conveying and mixing elements and temperature controlled modular barrels that constitute a continuous reaction vessel. Along the extruder length, one or more liquid injection and powder feed ports are inserted in the barrels, wherein the number and location of the ports are dictated by the complexation process requirements.
• the complex may be prepared by a variety of processes known in the art.
• the drug to substrate ratio in the complex varies from 1:10 to 10:1, preferably from 1:5to 5:1, and more preferably from 1:3 to 3:1.
• the therapeutic agent-substrate complex is blended with the thermoplastic polymer and optionally at least one pharmaceutical additive, and the blend melt granulated at processing temperatures of less than 200° C. and preferably less than 150° C. using a twin-screw extruder.
• a blend of the thermoplastic polymer and optionally at least one pharmaceutical additive is fed into the extruder through the first powder feed port and allowed to melt before the therapeutic agent-substrate complex is introduced through a second powder feed port downstream from the first feed port and mixed with the molten mass in the extruder.
• the melt granulated material or extrudate is shaped downstream to provide tamper-resistant tablets or multiparticulates that are filled into capsules or compressed into tablets.
• the ratio of the therapeutic agent-substrate complex to the thermo-formable matrix varies from 1:20 to 20:1, and preferably from 1:10 to 10:1, and more preferably from 1:5: to 5:1.
• the tamper-resistant dosage form according to the invention is resistant to breaking, chewing, crushing and grinding.
• the therapeutic agent-substrate complex is embedded into a thermo-formable matrix to form a dosage form that does not break or deform at least for up to 350 N when tested on a tablet hardness tester. Storing the dosage form at 0° C. temperature prior to the application of force does not bring about a change in the physical properties of the dosage form. Communition of the dosage form using conventional milling equipment is not possible.
• Examples of prescription drugs abused by swallowing include; barbiturates such as phenobarbital and secobarbital; opioids such as morphine, codeine, fentanyl, methadone, oxycodone HCl, hydrocodone bitartrate, hydromorphone, oxymorphone, meperidine, propoxyphene and dextromethorphan; benzodiazepines such as diazepam and clonazepam; sleep medications such as zolpidem and zaleplon; and stimulants such as amphetamine and methylphenidate.
• barbiturates such as phenobarbital and secobarbital
• opioids such as morphine, codeine, fentanyl, methadone, oxycodone HCl, hydrocodone bitartrate, hydromorphone, oxymorphone, meperidine, propoxyphene and dextromethorphan
• benzodiazepines such as diazepam and clonaze
• the dosage form according to the invention is resistant to snorting. Since the dosage form does not get reduced into fine powder, it does not allow the abuser to administer the therapeutic agent intra-nasally to facilitate drug absorption through the lining of the nasal passages by snorting. Even if the tablet were to be pulverized, the therapeutic agent would still be tightly bound to the substrate and not become available for intra-nasal absorption.
• Examples of prescription drugs abused by snorting include: opioids such as morphine, codeine, fentanyl, methadone, oxycodone HCl, hydrocodone bitartrate, hydromorphone, oxymorphone, meperidine and propoxyphene; sleep medications such as zolpidem and zaleplon; stimulants such as amphetamine and methylphenidate.
• opioids such as morphine, codeine, fentanyl, methadone, oxycodone HCl, hydrocodone bitartrate, hydromorphone, oxymorphone, meperidine and propoxyphene
• sleep medications such as zolpidem and zaleplon
• stimulants such as amphetamine and methylphenidate.
• the dosage form according to the invention prevents extraction of the therapeutic agent using commonly used organic and household solvents. Continuous agitation of the dosage form or its fragments in 30 mL or 200 mL extraction volume for at least 8 hours leads to insignificant drug release. As a result, the dosage form is expected to be resistant to abuse by injection. Examples of prescription drugs abused by injection include: barbiturates, such as phenobarbital and secobarbital; opioids such as morphine, codeine, fentanyl, methadone, oxycodone HCl, hydrocodone bitartrate, hydromorphone, oxymorphone, meperidine and propoxyphene; stimulants such as amphetamine and methylphenidate.
• barbiturates such as phenobarbital and secobarbital
• opioids such as morphine, codeine, fentanyl, methadone, oxycodone HCl, hydrocodone bitartrate, hydromorphone, oxymorphone, meperidine and propoxyphen
• the present invention relates to a dosage form that prevents drug abuse by smoking where the therapeutic agent needs to vaporize for inhalation after exposure of the dosage form to heat.
• the dosage form is placed on top of an aluminum foil, and heated from underneath the foil to vaporize the therapeutic agent.
• the therapeutic agent-substrate complex has much lower vapor pressure than that of the free drug, which would require much higher heat energy to liberate the free drug from the complex.
• the matrix also provides additional barrier to drug vaporization. Excessive heating of the dosage form leads to decomposition and charring of formulation components. Examples of prescription drugs abused by smoking include: fentanyl and its analogs, amphetamines, and morphine.
• the present invention relates to two or more dosage forms that provide similar abuse deterrent properties, and yet generate a variety of dissolution profiles that meet predetermined pharmacokinetic requirements.
• multi-solvent extraction data from dosage forms comprising five different formulations demonstrated similar but insignificant drug release irrespective of the agitation time and extraction volume.
• the present invention relates to a dosage form that minimizes or eliminates oxidative or hydrolytic decomposition of therapeutic agents.
• Many therapeutic agents including opioids, undergo oxidative or hydrolytic degradation when exposed to acidic or alkaline aqueous environments or thermal stresses, or both.
• some pharmaceutical additives such as polyethylene oxide, contain trace amounts of peroxides and promote oxidation of the therapeutic agent upon storage or during thermal processing, and, as a result, anti-oxidants and buffering agents are routinely added to formulations to prevent potential for degradation of therapeutic agents through the shelf-life of the dosage forms.
• the formation and incorporation of the drug-substrate complex within the thermo-formable matrix obviates the need for incorporating anti-oxidants and buffering agents in the dosage form.
• the invention in yet another embodiment, relates a tamper-resistant dosage form comprising tablets and multi-particulates that release the therapeutic agent for up to 24 hours. Multiparticulates are blended with other tableting excipients and compressed prior to dissolution testing. During dissolution, the compressed tablets disintegrate in less than a minute to regenerate the original maltiparticulates.
• the tamper-resistant dosage form is prepared by blending the therapeutic agent-substrate complex, a thermoplastic polymer and at least one pharmaceutical additive, and granulated using conventional dry granulation or wet granulation/drying processes followed by compression into tablets. Once again the therapeutic agent-substrate complex is embedded within the thermo-formable matrix in the dosage form.
• a drug-ion exchange resin complex can be prepared from a blend of the drug and Amberlite IRP 69 using a novel reactive extrusion process.
• a 16 mm twin-screw extruder was used as a reactor, although larger size extruders could be used if the desired yield is high.
• the drug and Amberlite IRP 69 were pre-blended and the blend introduced into the extruder through a powder feed port.
• deionized water was added at a controlled rate to generate a heavy suspension.
• the extrusion process was carried out at a screw speed of 300 rpm and processing temperatures of 25° C.
• the drug-Amberlite IRP complex can be prepared by other methods known in the art.
• the suspension was collected and washed using deionized water to remove any free uncomplexed drug.
• the supernatant was decanted and discarded.
• the residue comprising a drug-ion exchange resin complex was then dried in an air forced oven at 40° C.
• Drug loading was determined using the following procedure: 20 mg of the drug ion-exchange complex was added to 200 mL of 2% NaCl solution in a flask and then agitated for 4 hrs. The suspension was filtered and the residue discarded. The amount of free drug in the supernatant was then determined.
• a therapeutic agent propranolol
• a substrate ion-exchange resin
• Propranolol ion exchange resin complex particles were prepared using the procedure described in Example 1.
• thermoplastic polymers hydroxypropylcellulose I and II
• sicon dioxide an additive
• Propranolol HCl (free drug), hydroxypropylcellulose (I), hydroxypropylcellulose (II) and silicon dioxide were blended, fed into a 16 mm twin screw extruder and extruded.
• the extrusion process was carried out at a processing temperature of 140° C. and a screw speed of 200 rpm.
• the extrudates were shaped into multiparticulates downstream. A portion of the multiparticulates were mixed with external excipients and compressed into tablets.
• the tablets and multiparticulates were collected and stored in high density polyethylene (HDPE) bottles.
• HDPE high density polyethylene
• a therapeutic agent propranolol
• a substrate Amberlite IRP 69
• thermoplastic polymers hydroxypropylcellulose I and II
• an additive silicon dioxide
• Propranolol HCl (free drug), Amberlite IRP 69 (uncomplexed resin), hydroxypropylcellulose (I), hydroxypropylcellulose (II) and silicon dioxide were blended, fed into a 16 mm twin screw extruder and extruded.
• the extrusion process was carried out at processing temperatures of 140° C. and a screw speed of 200 rpm.
• the extrudates were shaped into multiparticulates downstream. A portion of the multiparticulates were mixed with external excipients and compressed into tablets.
• the tablets and multiparticulates were collected and stored in high density polyethylene (HDPE) bottles.
• HDPE high density polyethylene
• the propranolol ion exchange complex, hydroxypropylcellulose (I), hydroxypropylcellulose (II) and silicon dioxide were blended, fed into a 16 mm twin screw extruder and extruded.
• the extrusion process was carried out at a processing temperature of 140° C. and a screw speed of 200 rpm.
• the extrudates were shaped into multiparticulates downstream. A portion of the multiparticulates were mixed with external excipients and compressed into tablets.
• the tablets and multiparticulates were collected and stored in high density polyethylene (HDPE) bottles.
• HDPE high density polyethylene
• Dextromethorphan ion exchange resin complex was prepared using the procedure described in Example 1.
• F-1 and F-2 Two different formulations (F-1 and F-2) containing dextromethorphan-Ion exchange resin complex were blended, fed into a 16 mm twin screw extruder and extruded at processing temperatures of 140° C. and screw speed of 200 rpm.
• the extrudate was converted into multiparticulates downstream.
• the multiparticulates were blended with appropriate external excipients to generate a tablet blend and subsequently were compressed into tablets.
• the tablets were collected and stored in high density polyethylene (HDPE) bottles.
• HDPE high density polyethylene
• F-1 F-2 Ingredient % w/w Dextromethorphan Ion Exchange Resin Complex 50 50 Hydroxypropyl cellulose (I) (M.W. 370,000) — 36.75 Hydroxypropylcellulose (II) (M.W. 80,000) — 12.25 Hydroxypropyl cellulose (III) (M.W. 1,150,000) 40 — Polyethylene glycol (M.W. 400) 4.5 — Talc 4.5 — Silicon dioxide 1.0 1.0 Total 100 100 Dissolution Studies:
• a dosage form should provide an in vitro release profile that achieves a target therapeutic effect and at the same time maintain the tamper resistant property to dissuade drug abusers.
• the data indicates that the invention satisfies the requirement: different dextromethorphan multiparticulate formulations can provide different dissolution profiles and yet have similar tamper resistant properties as demonstrated by the low level of extractability using different extraction solvents.
• a mixture of Dextromethorphan ion exchange resin complex, hydroxypropylcellulose (I), hydroxypropylcellulose (II) and polyethylene glycol were blended and fed into a 16 mm twin screw extruder and extruded at extrusion temperatures of 100° C. and a screw speed of 200 rpm.
• the extrudate was shaped into tablets downstream.
• the tablets were collected and stored in high density polyethylene (HDPE) bottles.
• HDPE high density polyethylene
• the data indicates that the invention permits the preparation of dextromethorphan tablets that have extended release dissolution profiles and at the same time provide tamper resistance as demonstrated by the low level of extractability of the therapeutic agent from the tablets using different extraction solvents.
• F-3 and F-4 Two different formulations (F-3 and F-4) containing Propranolol-Ion exchange resin complex were blended and fed into a 16 mm twin screw extruder and extruded at processing temperatures of 100° C. and screw speed of 200 rpm.
• the extrudates were shaped into tablets in a downstream processing step.
• the tablets were collected and stored in high density polyethylene (HDPE) bottles.
• HDPE high density polyethylene
• the data demonstrates that the invention permits the development of different Propranolol-ion exchange formulations that have different dissolution profiles and at the same time provide similar tamper resistant properties as demonstrated by the low level of extractability of the therapeutic agent from the tablets.
• release profiles of dosage forms can be modified using erosion enhancers without compromising the tamper resistance properties of the dosage forms.
• a mixture of Propranolol ion exchange resin complex, hydroxypropylcellulose (I), hydroxypropylcellulose (II), polyethylene oxide, polyethylene glycol and silicon dioxide were blended and fed into a 16 mm twin screw extruder and extruded at extrusion temperatures of 140° C. and a screw speed of 200 rpm.
• the extrudate was shaped into tablets downstream.
• the tablets were collected and stored in high density polyethylene (HDPE) bottles.
• HDPE high density polyethylene
• the data demonstrates that the invention permits the development of Propranolol-ion exchange formulations that contain viscosity enhancing polymer and at the same time provide similar tamper resistant properties as demonstrated by the low level of extractability of the therapeutic agent from the tablets.

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• 2014
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