US691157A - Trimethyl hexahydroöxybenzylanilin and process of making same. - Google Patents

Description

UNITED STATES PATENT OFFICE.

GEORG MERLING, OF FRANKFORT-ON-THE-MAIN, GERMANY, ASSIGNOR TO THE FARBWERKE, VORM. MEISTER, LUOIUS & BRUNING, OF I-IOCHST-ON- THE-MAIN, GERMANY, A CORPORATION OE GERMANY.

TRIMETHYL HEXAHYDFIOUXYBENZYLANILIN AND PROCESS OF MAKING SAME.

SPECIFEGATEQN forming part of Letters Patent No. 691 ,157, dated January 14, 1

Application filed July 7,1900. Serial No. 22,771. (Specimens) To all whom it may concern: Thus, for instance, anilidomethylenemen- Beitknown that I, GEORG 1VIERLING,Ph.D., thone a citizen of the Empire of Germany, residing CH3 CH3 at Frankfort-on-the-lI/Iain, Germany, have in- 45 5 vented certain new and useful Improvements in the Manufacture of I-Iexahydrooxyben- CH zylamin Bases, of which the following is a CH2 CO specification. I

I have found that the amidomethylenecy- Y 5 1o cloketones, having the general formula CH1 O=OHTIHCH=H c on c I O=OHN E C HH l on reduction yields isopropyl-methyl-oxy- 5 o co hexahydrobenzylanilin 0 CH\39H3 (wherein R represents either hydrogen or a fatty or aromatic radical) formed by the OH action of'ammonia or primary and secondary OH OH OH fatty or aromatic amins on formyl or oXymethylenecycloketone of the type on cH cH, Nnc,n, O 5 c c=c1I -oH I I 0H G '00 Again, ethylarnidomethylenementhone CH3 0H,,

o 3 on are transformed when treated with reducing agents, preferably with sodium and alcohol, into hydrogenized oxybenzylamin bases of 2 the type 1 1 35 0. 0H, c=cn--Nl-m .l-i

c 0H-cH,-N

I I OH so 0 CH-OH 4o I yields lsopropyl methyloxy'hexahydroben Q zylethylamin I CH2 orpcmnqncm I on,

and anilido methylenedihydroisophorone 0H, 'cH,

. on, yields trimethyl-oXy-hexahydrobenzylanilin OH\3\9H3 CH CH i CH-OH Example I. Transformation of anilidome-' thylenecamphor (see Olaisen: Ann. Chem,

into the hexahydrobase one kilo of anilidomethylenecamphor thoroughly dried (Claisen: A'rm. Ghent, 281, 358) is dissolved in ten kilos of absolute alcohol distilled in the presence of sodium, and into this solution contained in an enameled vessel provided with an inverted condenser one kilo of sodium is gradually introduced. Toward the end of the reaction heating is necessary. The sodium having disappeared, the alcohol and a small portion of borneol and anilin formed as by-product are distilled with steam. The oxybase remains behind as a brownish very viscous layer of oil contaminated by some camphylglycol formed along with it.

To purify the base, it is dissolved in ether, and the etherial solution is dried in the pres ence of anhydrous sodium sulfate, and the hydrochlorid is precipitated with hydrochloric-acid gas.

on, into trimethyl-hexahydro-oXy-benzylanilin:

omen,

This compound is readily soluble in alcohol, ether, and benzene.

First. Manufacture of oxymethylenedihydroisoph rone:

on C=CH.OH

OH3-CH I l 00 on, The hitherto unknown oxymethylenedihydroisophorone is easily obtained from pure dihydroisophorone (see Knovenagel: Arm. Chem,

297, 198) by introducing ninety-nine parts, by

weight, of it mixed with eighty-four parts of formic acid amylester into 48.1 parts of finelypulverized sodiumethylate dissolved in three hundred parts of absolute ether and contained in a vessel provided with an inverted condenser. The liquid becomes heated by itself,

while the sodiumethylate quickly dissolves. If the liquid boils too fast, the reaction has to be moderated by in trod uoing the vessel into ice-water. After about fifteen minutes the solution solidifies to a crystalline paste of oxy'methylenedihydroisophoronesodium. After standing for twelve hours five hundred parts of water are added and the etherial solution is separated from the alkaline layer, which is extracted by shaking with ether.

' From the alkaline solution dilute acetic acid precipitates the oxymethylenedihydroisophorone as a yellowish layer of oil, which is extracted with ether and after being washed several times with small quantities of water is dried in the presence of sodium sulfate. The ether being filtered, the oxymethylenedihydroisophorone remains behind as a yellow oil boiling in oacuo (twenty-seven millimeters pressure) at 124 without being decomposed. A colorless oil, resembling in odor the oxymethylenementhone. (Glaisen: Ann. Chem, 284, 394.)

Second. Manufacture of anilidomethylenedihydroisophorone:

on, on,

CH --CH 00 a If sixty-five parts of anilin dissolved in acetic acid of thirty per cent. strength are added to a solution of one hundred and ten parts of oxymethylenedihydroisophorone in three hundred parts of methyl alcohol, then the anilidomethylenedihydroisophorone is at once precipitated as a yellow oil, which after a short time solidifies to a yellow crystalline mass. The compound is very readily soluble in all the usual solvents. After being washed with water it is thoroughly dried for the reduction described hereinafter in vacuo by means of sulfuric acid.

Third. Reduction of anilidomethylenedihydroisophorone to trimethyl-oxyhexahydrobenzylanilin:

on, on,

c on, 1 I on-cm-ivnc n,

The reduction is carried out exactly in the same manner as that in Example I of anilidomethylenecamphor. The reactions are similar in both cases.

To obtain the base remaing as viscouscolorless oil in the distilling vessel in a pure state, the hydrochlorid is precipitated from its dried etherial solution by introducing hydro chloric-acid gas. An excess of hydrochloric acid is to be avoided, as it acts as solvent on the hydrochlorid of the base.

The hydrochlorid of trimethyloxyhexahydrobenzylanilin is a colorless crystalline powder, readily soluble in cold water, which is to be taken into consideration in its manufacture.

The base separated from the hydrochlorid by means of soda-lye is solid. It crystallizes from hotligroin in needles of the meltingpoint, 68 to 70, and boils in vacuo (fifteen millimeters pressure)at 221 without being decomposed.

Example III. Transformation of amidome- I thylenementhone:

into isopropyl-methyl-hexahydro-oxy-benzylamin First. Manufacture of amidomethylenementhone:

CIH on, crrorr on: C'H,

One part of amidomethylenemcnthone thoroughly dried is dissolved in ten parts of absolute alcohol, and into this solution, contained ina vessel provided with an inverted condenser, is gradually introduced one part as experiments have shown.

of sodium. On the disappearance of the sodium (the reaction has to be accelerated toward theend by heating) the solution is diluted with water and the alcohol is distilled with steam. As the base is somewhat Volatile withsteam, the reaction isinterrupted as soon as the filtrate becomes turbid. The isopropylmethyloxyhexahydrobenzylan1in remains in the vessel as a colorless layer of oil. To purify it from small portions of indifferent compounds, the oil is dissolved in ether and the etherial solution is repeatedlyextracted with dilute hydrochloric acid. From the solution of the hydrochlorid soda-lye precipitates the base as an oil,which is again extracted with ether and dried in the presence of anhydrous sodium sulfate. After distilling the ether the base remains as a colorless oil, boiling in vacuo (thirty millimeters pressure) at 150 to 151, which slowly solidifies on cooling to a colorous crystalline mass. The base thus obtained is not homogeneous, It consists of a mixture of two stereoisomeric modifications, which by the different solubility of their hydrochlorids are easily separated by means of benzene. For this purpose the mixture of the bases of the boiling-point, 150 to 151, (thirty millimeters pressure,) is dissolved in benzene while introducing an excess of hydrochloric-acid gas. Then the hydrochlorid of one of the modifications is separated, which may be designated as trans isopropylmethyl-oxyhexahydrobenzylamin, while the hydrochlorid of the cis-isopropylmethyl-oxyhexahydrobenzylamin remains dissolved. The bases separated from the two hydrochlorids are again separately treated in the same manner, and thus a complete separation of the isomers is obtained. Thus it has been proved that the raw base consists of about one-third of trans-base and of two-thirds of cis-base. Both bases solidify at once after distillation in vacuo to dazzling white crystalline masses. The cis-isopropylmethyl-oxyhexahydrobenzylamin boils at 165 to 170 (thirty millimeters pressure) and the transisopropylmethyl-oxyhexahydrobenzylamin at 163, (thirty millimeters pressure.) Both isomers are clearly soluble in dilute mineral acids. In a similar way are manufactured:

First. From the hitherto unknown anilidomethylenementhone (oil) isopropyl-methylhexahydro-oXy-benzylanilin cri on on ch on,

millimeters pressure.)

eerie?" Second. From the hitherto unknown dimethylamidomethylenementhone (oil forming a hydrate crystallizing in laminae) isopropyl methyl hexahydro oxy benzyldimethylamin on on I on on CHOH oil; boiling-point 140, (fourteen millimeters pressure.)

Third. From the hitherto unknown oily ethylamidomethylenementhone isopropylmethyl-hexahydro-oXy-benzylethylamin on on,

OHCH2NHC2H5 on at,

oil; boiling-point 165 to 166, (nineteen millimeters pressure.)

Fourth. From the hitherto unknown oxymethylenemethylcyclohexanone:

l crr crr I oo on czorron at first by the action of anilin the hitherto unknown anilidomethylene-methylcycloheX- anone, yellow crystals; melting-point 170 to 171, and from this methyl-hexahydro-oxybenzylanilin wherein R represents either hydrogen, or a fatty or aromatic radical, which consists in lo treating amidomethylenecyclolgetones of the type:

obtained by the action of ammonia upon ke- 20 tones of the general formula:

with reducing agents, substantially as set forth.

2. As a new product, the trimethylhexa- 3o hydro-oxybenzylanilin, having the formula:

cn -on CHOH GEORG MERLING.

Witnesses HEINRICH HAHN, ALFRED BRISBOIS.