US657003A - Glycerinized vaccine lymph. - Google Patents
Glycerinized vaccine lymph. Download PDFInfo
- Publication number
- US657003A US657003A US398900A US1900003989A US657003A US 657003 A US657003 A US 657003A US 398900 A US398900 A US 398900A US 1900003989 A US1900003989 A US 1900003989A US 657003 A US657003 A US 657003A
- Authority
- US
- United States
- Prior art keywords
- glycerinized
- lymph
- vaccine
- compound
- vaccine lymph
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 210000002751 lymph Anatomy 0.000 title description 19
- 229960005486 vaccine Drugs 0.000 title description 11
- 150000001875 compounds Chemical class 0.000 description 8
- 210000002966 serum Anatomy 0.000 description 6
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 4
- 238000001035 drying Methods 0.000 description 3
- 230000001066 destructive effect Effects 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 235000011187 glycerol Nutrition 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 230000001627 detrimental effect Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
Definitions
- My invention relates to what is called indifferently glycerinized, glycerinated, glycerized, or glycerated vaccine lymph, but which I shall term glycerinized vaccine lymph.
- Glycerinized vaccine lymph is an aseptic body composed of vaccine lymph mixed with at least an equal part, by weight, of glycerine, which latter sterilizes the lymph and renders it aseptic.
- the compound is fluid and without drying properties.
- the object of my invention is to obtain glyccrinized vaccine lymph which will dry upon the ivory or other point to which it may be applied. I-Ieretofore, so far as I am informed, this result has never been attained in any way. I have discovered that I can obtain glycerinized lymph possessing this characteristic by mixing with the glycerinized lymph a sterile albuminous element having no destructive effect either on the aseptic character of the compound or on the active principle of the vaccine lymph.
- the albuminous element or drier possessing these properties which I prefer to employ is blood serum, which when obtained under proper known safeguards is sterile and which exercises no destructive or detrimental effect upon the active vaccine principle. The proportions of this ingredient may vary.
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Description
UNiTnD STATES PATENT OFFICE.
EDlVARD MASON PARKER, OF WASHINGTON, DISTRICT OF COLUMBIA.
GLYCERINIZED VACCINE LYMPH.
$PECIFICATION' forming part'of Letters Patent No. 657,003, dated August 28, 1900. Application filed February 5,1900. Serial No. 3 989. (No specimens.)
T0 ctZZ whom it may concern.-
Be it known that I, EDWARD MASON PAR- KER, a citizen of the United States, and a resident of Washington city, in the District of Columbia, have invented a new and useful ImprovementinGlycerinizedVaccine Lymph, of which the following is a specification.
My invention relates to what is called indifferently glycerinized, glycerinated, glycerized, or glycerated vaccine lymph, but which I shall term glycerinized vaccine lymph.
Glycerinized vaccine lymph is an aseptic body composed of vaccine lymph mixed with at least an equal part, by weight, of glycerine, which latter sterilizes the lymph and renders it aseptic. The compound, however, is fluid and without drying properties.
The object of my invention is to obtain glyccrinized vaccine lymph which will dry upon the ivory or other point to which it may be applied. I-Ieretofore, so far as I am informed, this result has never been attained in any way. I have discovered that I can obtain glycerinized lymph possessing this characteristic by mixing with the glycerinized lymph a sterile albuminous element having no destructive effect either on the aseptic character of the compound or on the active principle of the vaccine lymph. The albuminous element or drier possessing these properties which I prefer to employ is blood serum, which when obtained under proper known safeguards is sterile and which exercises no destructive or detrimental effect upon the active vaccine principle. The proportions of this ingredient may vary. Thus far I have obtained the best results by adding the blood serum to the glycerinized lymph in the proportion, by weight,of fifteen parts of the blood 40 serum to one part of the glycerine element of glycerinized lymph. The sterile albuminous drying element should be thoroughly mixed with the glycerinized lymph. If this compound be applied to an ivory point, it will dry thereon. I prefer to add all of the blood serum or its equivalent to the glycerinized lymph in the first instance and before applying the compound to an ivory point; but I can mix a reduced proportion of the blood serum with the glycerinized lymph in the first instance, so as to obtain a compound which, while not fluid like ordinary glycerinized lymph, is gummy or slightly sticky or soft, and then after applying the compound to an ivory-point 5 5 I can dip the point in or coat it with the blood serum until enough of the latter has been taken up and absorbed by the vaccine compound to cause said compound to dry 011 the point.
What I claim as my invention is- A new composition of matter obtained by the admixture with glycerinized vaccine lymph of a sterilealbuminous drying element, substantially as hereinbefore set forth.
In testimony whereof I have hereunto set my hand this 3d day of February, 1900.
EDlVARI) MASON PARKER.
Witnessesi JoHN E. MITCHELL, GEORGE M. EvANs.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US398900A US657003A (en) | 1900-02-05 | 1900-02-05 | Glycerinized vaccine lymph. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US398900A US657003A (en) | 1900-02-05 | 1900-02-05 | Glycerinized vaccine lymph. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| US657003A true US657003A (en) | 1900-08-28 |
Family
ID=2725571
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| US398900A Expired - Lifetime US657003A (en) | 1900-02-05 | 1900-02-05 | Glycerinized vaccine lymph. |
Country Status (1)
| Country | Link |
|---|---|
| US (1) | US657003A (en) |
-
1900
- 1900-02-05 US US398900A patent/US657003A/en not_active Expired - Lifetime
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