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US5254112A - Device for use in laser angioplasty - Google Patents

Device for use in laser angioplasty Download PDF

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Publication number
US5254112A
US5254112A US07/604,931 US60493190A US5254112A US 5254112 A US5254112 A US 5254112A US 60493190 A US60493190 A US 60493190A US 5254112 A US5254112 A US 5254112A
Authority
US
United States
Prior art keywords
catheter
transducer
blood vessel
energy
modulating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
US07/604,931
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English (en)
Inventor
Edward Sinofsky
W. Scott Andrus
Michael Madden
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rare Earth Medical Lasers Inc
Cardiofocus Inc
Original Assignee
CR Bard Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CR Bard Inc filed Critical CR Bard Inc
Priority to US07/604,931 priority Critical patent/US5254112A/en
Assigned to C. R. BARD, INC., A NEW JERSEY CORP. reassignment C. R. BARD, INC., A NEW JERSEY CORP. ASSIGNMENT OF ASSIGNORS INTEREST. Assignors: ANDRUS, W. SCOTT, MADDEN, MICHAEL, SINOFSKY, EDWARD
Priority to AU89461/91A priority patent/AU8946191A/en
Priority to PCT/US1991/007474 priority patent/WO1992007623A1/fr
Application granted granted Critical
Publication of US5254112A publication Critical patent/US5254112A/en
Assigned to RARE EARTH MEDICAL LASERS, INC. reassignment RARE EARTH MEDICAL LASERS, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: C.R. BARD, INC.
Assigned to RARE EARTH MEDICAL, INC. reassignment RARE EARTH MEDICAL, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: C.R. BARD, INC.
Assigned to CARDIOFOCUS, INC. reassignment CARDIOFOCUS, INC. CHANGE OF NAME (SEE DOCUMENT FOR DETAILS). Assignors: RARE EARTH MEDICAL, INC.
Assigned to CARDIOFOCUS, INC. reassignment CARDIOFOCUS, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: CARDIOFOCUS, INC.
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/12—Diagnosis using ultrasonic, sonic or infrasonic waves in body cavities or body tracts, e.g. by using catheters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
    • A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
    • A61B18/22—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser the beam being directed along or through a flexible conduit, e.g. an optical fibre; Couplings or hand-pieces therefor
    • A61B18/24—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser the beam being directed along or through a flexible conduit, e.g. an optical fibre; Couplings or hand-pieces therefor with a catheter
    • A61B18/245—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser the beam being directed along or through a flexible conduit, e.g. an optical fibre; Couplings or hand-pieces therefor with a catheter for removing obstructions in blood vessels or calculi
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
    • A61B5/02007—Evaluating blood vessel condition, e.g. elasticity, compliance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/08—Clinical applications
    • A61B8/0833—Clinical applications involving detecting or locating foreign bodies or organic structures
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/44—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device
    • A61B8/4444—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device related to the probe
    • A61B8/445—Details of catheter construction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/44—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device
    • A61B8/4483—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device characterised by features of the ultrasound transducer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B2017/00017—Electrical control of surgical instruments
    • A61B2017/00022—Sensing or detecting at the treatment site
    • A61B2017/00106—Sensing or detecting at the treatment site ultrasonic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/08—Clinical applications
    • A61B8/0858—Clinical applications involving measuring tissue layers, e.g. skin, interfaces

Definitions

  • This invention relates to the laser ablation of human tissue.
  • Atherosclerotic plaque deposits tend to occlude and thus restrict the f low of blood in coronary arteries. Such deposits are a major cause of heart disease and various techniques have been proposed to remove atherosclerotic plaque without requiring surgery.
  • Ultrasonic diagnosis has been proposed also to avoid possible perforation of an arterial wall during laser angioplasty.
  • ultrasonic pulses are transmitted toward the arterial wall and the time of arrival of the echoes from the tissue interfaces measured. Knowing the velocity of sound, the distance (range) of each tissue layer from the catheter can be calculated to provide a visual image of the cross-section of the arterial wall scanned by the ultrasound. The image reflects the thickness of the arterial wall so that the operator knows not to ablate tissue where the arterial wall is dangerously thin.
  • the cross-sectional image can be used to help distinguish plaque deposits from arterial tissues to ensure that the high energy laser ablation pulses are directed only at the atherosclerotic tissue.
  • the main object of the present invention is to provide an improved catheter construction for use in laser angioplasty wherein the elements required for delivery of the energy used for range sensing and ablation are contained within the catheter.
  • a more specific object is to provide an improved catheter construction which includes an ultrasonic transducer for use in laser angioplasty wherein the likelihood of accidental perforation of the arterial wall is reduced.
  • a further object of the invention is to provide a catheter construction including an ultrasonic transducer for use in laser angioplasty wherein ultrasonic imaging can be achieved with a minimum number of wires, possibly none, thereby reducing space requirements and simplifying the construction.
  • a still further object of the invention is to provide an ultrasonic imaging system for use in laser angioplasty which has a low space requirement and is easier to install in the catheter.
  • a catheter for use in removing diseased tissue comprises at least one optical fiber extending the length of the catheter for transmitting laser pulses, a transducer mounted at the distal end of the catheter and adapted to transmit ultrasonic energy in a direction generally radial of the catheter when irradiated by laser energy transmitted through said fiber, and means for detecting the acoustical energy reflected from tissue interfaces on which the ultrasonic energy impinges.
  • Range information is generated by the detecting means based on the time of arrival of the reflected ultrasonic pulses which represent, in known fashion, the distance from the catheter to the tissue interfaces. This provides a reliable indicator of the thickness of the arterial wall and, secondarily, the presence of atherosclerotic plaque. Armed with this information, an operator is less likely to direct the high power laser energy at a dangerously thin area of the arterial wall.
  • the invention contemplates various detection means including both electrical and optical means for producing information indicative of the ultrasonic signals reflected from the tissues surrounding the catheter tip.
  • FIG. 1 is a side cross-sectional view showing a catheter construction in accordance with a first embodiment of the invention
  • FIG. 2 is a side cross-sectional view similar to FIG. 1 showing a catheter construction in accordance with a second embodiment of the invention
  • FIG. 3 is a cross-sectional view along the line 3--3 of FIG. 1;
  • FIG. 4 is a cross-sectional view along the line 4--4 of FIG. 1.
  • the principles of the invention can be employed to ablate atherosclerotic plaque or other types of diseased tissues such as cancerous growths.
  • the invention is intended to be used for the ablation of atherosclerotic plaque; accordingly, the description of the preferred embodiment is directed to laser angioplasty.
  • FIG. 1 shows an occlusion caused by an atherosclerotic plaque deposit 10 within blood vessel (artery) 12.
  • a catheter 14 in the form of an elongated, flexible tube is dimensioned so that it can be inserted and advanced through a patient's coronary artery.
  • Catheter 14 has a central through lumen so that it can be guided over a standard guide wire (not shown) in conventional fashion.
  • the catheter 14 comprises an inner core 16 and a shaft 18 which may include, for example, seven lumens 20.
  • optical fibers 22 are positioned in respective ones of the lumens 20. The distal ends of the optical fibers 22 are retained in an annular holder 24 which is supported on the distal end of the core.
  • the two part catheter construction is used to facilitate the introduction of the optical fibers 22 and the electrical wires (described below) into the wall of the catheter.
  • the shaft 14 and core 16 should be able to slide with respect to each other and the fibers 22 should be loose within the lumens 20.
  • An ultrasonic transducer in the form of a metal cap 26 having a conical proximal surface 27 is supported on a transparent collar 28 at the distal tip of the catheter.
  • the collar 28 is made of a transparent material (for example artificial sapphire or fused silica) and thus functions as a window so that the laser energy transmitted through any one of the optical fibers 22 will impinge on the conical surface 27 of the metallic cap 26.
  • Cap 26 is made of a metal such as aluminum or other metal such as gold which has the capability of producing ultrasonic energy when struck by a pulse of laser energy.
  • the ultrasonic energy produced by transducer 26 results from rapid thermal stress in the metal element caused by a laser pulse.
  • the ultrasonic frequency is inversely related to the duration of the pulse. Typical useful ultrasonic frequencies are in the range of 1-20 MHz. For example, using a nitrogen laser operating at a wavelength of 337 nanometers, a laser pulse duration in the order of 2 nanoseconds will result in a range of ultrasonic frequencies up to 500 MHz. In accordance with the invention, a broad spectrum of ultrasonic frequencies will be generated.
  • the ultrasonic frequency determines the depth to which the acoustical energy will be propagated into the tissue and the measurement resolution.
  • a detector frequency or frequencies may be determined empirically. It is contemplated that a detector sensitive to 20 MHz frequency may be used to provide the range information and, consequently, the critical data on arterial wall thickness.
  • the conical surface 27 of the transducer 26 is oriented with respect to the circumferentially arrayed optical fibers 22 so that the ultrasonic energy is propagated generally in a perpendicular or radial direction (slightly proximally) with respect to the axis of the catheter.
  • the angular (azimuthal) direction in which the ultrasonic energy is directed depends on which of the circumferentially arrayed fibers is used to energize the transducer 26.
  • the entire blood vessel can be scanned. This is beneficial as compared to some types of ultrasound scanning devices wherein the transducer must be rotated to cover a circumferential area.
  • individual metallic members suitably oriented with respect to the respective optical fibers 22 may be used, or the surface may be segmented so that ultrasound is emitted only from the segment struck by the laser energy.
  • a piezoelectric ultrasound transducer comprises a polyvinylidine fluoride (PVDF) film 32 coated on its inner and outer surfaces with gold layers 34 and 36, respectively.
  • the gold layers 34 and 36 function as electrodes and are coupled to suitable electrical leads 38 which may be passed to the proximal end of the catheter through the walls of the catheter in the same fashion as the optical fibers 22 although, for purposes of clarity, the leads 38 are shown as passing through the central through lumen of the catheter.
  • the transducer is wrapped around the holder 24 and can detect ultrasonic energy reflected from the blood vessel from any azimuthal direction.
  • the proximal end of the catheter may terminate in a connector 38 (shown schematically in FIG. 1) or other suitable device for enabling the catheter to be connected through a complementary connector 39 to a source of high power laser energy 42 or a source of low power laser energy 43.
  • An optical switch 46 selectively connects high power laser 42 or low power laser 43 to the optical fibers 22 so that energy from either laser can be applied selectively to any desired one of the circumferentially arrayed fibers.
  • the electrical leads 18 from the piezoelectric transducer 32 are coupled directly to the diagnostic equipment 44 to provide an appropriate indication of the tissue interfaces being irradiated by the ultrasonic energy from the cap 26.
  • the ultrasonic information from the various fibers may also provide an indication of the presence of plaque although the main purpose of the ultrasonic scanning is to avoid perforation of the artery as opposed to recognizing the presence of plaque.
  • the invention contemplates any possible use of the information obtained from the ultrasonic scan in accordance with the invention.
  • the laser 42 can be energized to convey a high energy laser output through any one of the optical fibers 22. Assuming that the ultrasonic energy from a particular fiber 22 has indicated that the arterial wall is thick enough so that the risk of perforation is minimal (and, possibly also, that the section of the artery being scanned contains plaque), by transmitting the high energy pulse through the same fiber, the operator is assured that the high energy laser pulse is being directed at the same section of the wall that the diagnostic procedure has indicated to be safe from perforation.
  • the high power laser energy can be applied until the plaque has been ablated. It is contemplated that the ablation and diagnostic procedures may alternate continuously with the lasers being appropriately controlled to cause first the generation of the ultrasound diagnostic pulses followed by the high power laser ablation pulses.
  • the laser used to generate the ultrasound diagnostic pulses may have a wavelength of two nanoseconds, an energy level of one millijoule, and a pulse rate of fifty pulses per second.
  • the laser used for ablation may be a Holmium YAG (Ho:YAG) laser with a wavelength of 2.1 micrometers, a pulse duration of 200 microseconds, an energy level of 100 millijoules to 1 joule, and a pulse rate of ten pulses per second.
  • Ho:YAG Holmium YAG
  • FIG. 2 illustrates a second embodiment of the invention in which the diagnostic information is conveyed optically to the proximal end of the catheter.
  • the collar comprises a stress birefringent crystal 48 (such as crystalline quartz) to detect the reflected ultrasonic energy.
  • a stress birefringent material rotates the polarization of the light passing through it in response to a stress applied to the material. In this case, the stress would be applied by the ultrasonic echoes from the walls of the blood vessel.
  • the distal end 52 of the transparent birefringent crystal 48 is coated with a material such as a conventional dielectric multilayer stack which transmits the laser pulse (for example, in the ultraviolet wavelength range) used to generate the ultrasonic energy.
  • This coating reflects laser energy at a second laser wavelength (for example 631 nm He Ne laser) that may be used for the detection of the reflected ultrasonic energy.
  • the low power laser 50 (for example, a Helium Neon laser) transmits continuous wave laser energy at this second wavelength through the selected optical fiber 22.
  • the low power continuous wave laser energy is reflected by the coating on the surface 52 so that at least a portion of the continuous infrared laser energy is transmitted back through the selected fiber 22 to the proximal end of the catheter for diagnosis. Sufficient energy will be reflected from the side of the catheter and scattered back by the surrounding tissue to enable measurement of the reflected infrared laser energy although other modifications may be desirable to enhance the amount of energy reflected.
  • the optical fibers 22 must each be of the type which preserves polarization.
  • the amplitude of the reflected continuous wave infrared laser energy passing through the polarization preserving fiber 22 toward the proximal end of the catheter will therefore depend on the magnitude of the stress applied to the crystal 48 by the reflected ultrasonic energy from the blood vessel.
  • This change in polarization can thus provide the means for diagnosing the character of the tissue irradiated by the ultrasonic energy from the transducer 26.
  • the reflected laser energy from the continuous wave low power laser 50 is modulated by the stress applied to the crystal 48, which in turn depends on the nature and ranges to the interfaces from which the ultrasonic echoes are reflected.
  • the optically transparent crystal 4 may comprise an acousto-optic material such as Lithium Niobate LiNbO 3 .
  • Such materials diffract or scatter light passing through them in response to the stress applied to the material by the reflected ultrasonic energy.
  • the fibers 22 it is not necessary that the fibers 22 be polarization preserving fibers since the diffraction of the laser energy in response to the stress applied to the crystal by the reflected ultrasonic energy will cause a change in amplitude of the reflected energy that can be analyzed for diagnostic purposes.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Surgery (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Radiology & Medical Imaging (AREA)
  • Vascular Medicine (AREA)
  • Gynecology & Obstetrics (AREA)
  • Optics & Photonics (AREA)
  • Electromagnetism (AREA)
  • Otolaryngology (AREA)
  • Cardiology (AREA)
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US07/604,931 1990-10-29 1990-10-29 Device for use in laser angioplasty Expired - Fee Related US5254112A (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US07/604,931 US5254112A (en) 1990-10-29 1990-10-29 Device for use in laser angioplasty
AU89461/91A AU8946191A (en) 1990-10-29 1991-10-10 Device for use in laser angioplasty
PCT/US1991/007474 WO1992007623A1 (fr) 1990-10-29 1991-10-10 Dispositif destine a etre utilise dans l'angioplastie par laser

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US07/604,931 US5254112A (en) 1990-10-29 1990-10-29 Device for use in laser angioplasty

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AU (1) AU8946191A (fr)
WO (1) WO1992007623A1 (fr)

Cited By (103)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5423806A (en) * 1993-10-01 1995-06-13 Medtronic, Inc. Laser extractor for an implanted object
US5464013A (en) * 1984-05-25 1995-11-07 Lemelson; Jerome H. Medical scanning and treatment system and method
US5468239A (en) * 1992-04-13 1995-11-21 Sorenson Laboratories, Inc. Apparatus and methods for using a circumferential light-emitting surgical laser probe
US5486170A (en) * 1992-10-26 1996-01-23 Ultrasonic Sensing And Monitoring Systems Medical catheter using optical fibers that transmit both laser energy and ultrasonic imaging signals
US5515850A (en) * 1993-06-07 1996-05-14 Hewlett-Packard Company Apparatus for coupling acoustic waves with an acoustic waveguide
US5562619A (en) * 1993-08-19 1996-10-08 Boston Scientific Corporation Deflectable catheter
US5601738A (en) * 1993-07-15 1997-02-11 Medizinisches Laserzentrum Lubeck Gmbh Method and apparatus for treating material with a laser
US5718231A (en) * 1993-06-15 1998-02-17 British Technology Group Ltd. Laser ultrasound probe and ablator
US5733281A (en) * 1996-03-19 1998-03-31 American Ablation Co., Inc. Ultrasound and impedance feedback system for use with electrosurgical instruments
US5738666A (en) * 1995-03-16 1998-04-14 Medtronic, Inc. Slit tip ventricular catheter and method of manufacturing same
US5776127A (en) * 1994-10-13 1998-07-07 The General Hospital Corporation Two-pulse, lateral tissue illuminator
US5807389A (en) * 1991-08-16 1998-09-15 Myriadlase, Inc. Laterally reflecting tip for laser transmitting fiber
US5840023A (en) * 1996-01-31 1998-11-24 Oraevsky; Alexander A. Optoacoustic imaging for medical diagnosis
US5876426A (en) * 1996-06-13 1999-03-02 Scimed Life Systems, Inc. System and method of providing a blood-free interface for intravascular light delivery
US5916210A (en) * 1990-01-26 1999-06-29 Intraluminal Therapeutics, Inc. Catheter for laser treatment of atherosclerotic plaque and other tissue abnormalities
EP0821567A4 (fr) * 1995-04-17 1999-07-28 W Gregory Chernoff Procede chirurgical
US5944687A (en) * 1996-04-24 1999-08-31 The Regents Of The University Of California Opto-acoustic transducer for medical applications
US5967984A (en) * 1995-06-30 1999-10-19 Boston Scientific Corporation Ultrasound imaging catheter with a cutting element
US6022309A (en) * 1996-04-24 2000-02-08 The Regents Of The University Of California Opto-acoustic thrombolysis
US6033371A (en) * 1991-10-03 2000-03-07 The General Hospital Corporation Apparatus and method for vasodilation
US6066127A (en) * 1997-09-30 2000-05-23 Nidek Co., Ltd. Laser treatment apparatus
US6086534A (en) * 1997-03-07 2000-07-11 Cardiogenesis Corporation Apparatus and method of myocardial revascularization using ultrasonic pulse-echo distance ranging
US6200307B1 (en) 1997-05-22 2001-03-13 Illumenex Corporation Treatment of in-stent restenosis using cytotoxic radiation
US6230568B1 (en) 1992-02-07 2001-05-15 Ultrasonic Sensing And Monitoring Systems, Inc. Method and apparatus for ultrasonic inspection of inaccessible areas
US6309352B1 (en) 1996-01-31 2001-10-30 Board Of Regents, The University Of Texas System Real time optoacoustic monitoring of changes in tissue properties
US20020013572A1 (en) * 2000-05-19 2002-01-31 Berlin Michael S. Delivery system and method of use for the eye
US6368318B1 (en) 1998-01-23 2002-04-09 The Regents Of The University Of California Opto-acoustic recanilization delivery system
US20020045890A1 (en) * 1996-04-24 2002-04-18 The Regents Of The University O F California Opto-acoustic thrombolysis
US6395016B1 (en) 1996-07-28 2002-05-28 Biosense, Inc. Method of treating a heart using cells irradiated in vitro with biostimulatory irradiation
US6405069B1 (en) 1996-01-31 2002-06-11 Board Of Regents, The University Of Texas System Time-resolved optoacoustic method and system for noninvasive monitoring of glucose
US6406486B1 (en) 1991-10-03 2002-06-18 The General Hospital Corporation Apparatus and method for vasodilation
US6440125B1 (en) 2000-01-04 2002-08-27 Peter Rentrop Excimer laser catheter
WO2002069824A1 (fr) * 2001-03-06 2002-09-12 Scimed Life Systems, Inc. Dispositifs et methodes de reparation tissulaire
US6475210B1 (en) * 2000-02-11 2002-11-05 Medventure Technology Corp Light treatment of vulnerable atherosclerosis plaque
US6498942B1 (en) 1999-08-06 2002-12-24 The University Of Texas System Optoacoustic monitoring of blood oxygenation
US6538739B1 (en) 1997-09-30 2003-03-25 The Regents Of The University Of California Bubble diagnostics
WO2003057061A1 (fr) 2002-01-08 2003-07-17 Bio Scan Ltd. Sonde de transducteur ultrasonique
US6669686B1 (en) * 1999-07-20 2003-12-30 Ajoy Inder Singh Method and apparatus for arterial ablation
US20040002679A1 (en) * 2000-02-15 2004-01-01 Hugh Trout Apparatus and method for performing a surgical procedure
US20040039378A1 (en) * 2000-06-01 2004-02-26 Lin Charles P. Selective photocoagulation
WO2003103473A3 (fr) * 2002-04-11 2004-04-01 Eva Corp Appareil et procede pour intervention chirurgicale
US20040067000A1 (en) * 2002-10-07 2004-04-08 Bates Kenneth N. Systems and methods for minimally-invasive optical-acoustic imaging
US20040082844A1 (en) * 1998-03-05 2004-04-29 Vardi Gil M. Optical-acoustic imaging device
US6751490B2 (en) 2000-03-01 2004-06-15 The Board Of Regents Of The University Of Texas System Continuous optoacoustic monitoring of hemoglobin concentration and hematocrit
US20040199151A1 (en) * 2003-04-03 2004-10-07 Ceramoptec Industries, Inc. Power regulated medical underskin irradiation treament system
US20050021013A1 (en) * 1997-10-21 2005-01-27 Endo Vasix, Inc. Photoacoustic removal of occlusions from blood vessels
US20050055015A1 (en) * 2002-10-17 2005-03-10 Buzawa David M. Laser delivery device incorporationg a plurality of laser source optical fibers
EP1485035A4 (fr) * 2002-02-21 2006-05-31 Broncus Tech Inc Dispositifs destines a appliquer de l'energie sur un tissu
US20060161145A1 (en) * 2000-06-01 2006-07-20 Massachusetts General Hospital Optical devices and methods for selective and conventional photocoagulation of the retinal pigment epithelium
US20060195021A1 (en) * 2003-04-24 2006-08-31 Esenal Rinat O Noninvasive blood analysis by optical probing of the veins under the tongue
US7169140B1 (en) 1994-02-22 2007-01-30 Boston Scientific Scimed, Inc. Methods of using an intravascular balloon catheter in combination with an angioscope
US20070116408A1 (en) * 2005-11-22 2007-05-24 Eberle Michael J Optical imaging probe connector
US20070123776A1 (en) * 2003-04-09 2007-05-31 Rami Aharoni Ultrasonic probing device with distributed sensing elements
US20080082078A1 (en) * 2001-05-21 2008-04-03 Eyelight, Inc. Glaucoma surgery methods and systems
US20080123083A1 (en) * 2006-11-29 2008-05-29 The Regents Of The University Of Michigan System and Method for Photoacoustic Guided Diffuse Optical Imaging
US7393330B2 (en) 1999-08-05 2008-07-01 Broncus Technologies, Inc. Electrosurgical device having hollow tissue cutting member and transducer assembly
US20080173093A1 (en) * 2007-01-18 2008-07-24 The Regents Of The University Of Michigan System and method for photoacoustic tomography of joints
US7422563B2 (en) 1999-08-05 2008-09-09 Broncus Technologies, Inc. Multifunctional tip catheter for applying energy to tissue and detecting the presence of blood flow
US20080221647A1 (en) * 2007-02-23 2008-09-11 The Regents Of The University Of Michigan System and method for monitoring photodynamic therapy
US7462162B2 (en) 2001-09-04 2008-12-09 Broncus Technologies, Inc. Antiproliferative devices for maintaining patency of surgically created channels in a body organ
US20090054763A1 (en) * 2006-01-19 2009-02-26 The Regents Of The University Of Michigan System and method for spectroscopic photoacoustic tomography
US7708712B2 (en) 2001-09-04 2010-05-04 Broncus Technologies, Inc. Methods and devices for maintaining patency of surgically created channels in a body organ
US20100218559A1 (en) * 2007-06-15 2010-09-02 Vesuvius Crucible Company High temperature roll
US7815590B2 (en) 1999-08-05 2010-10-19 Broncus Technologies, Inc. Devices for maintaining patency of surgically created channels in tissue
US8002740B2 (en) 2003-07-18 2011-08-23 Broncus Technologies, Inc. Devices for maintaining patency of surgically created channels in tissue
US8308682B2 (en) 2003-07-18 2012-11-13 Broncus Medical Inc. Devices for maintaining patency of surgically created channels in tissue
US8409167B2 (en) 2004-07-19 2013-04-02 Broncus Medical Inc Devices for delivering substances through an extra-anatomic opening created in an airway
US8560048B2 (en) 2008-10-02 2013-10-15 Vascular Imaging Corporation Optical ultrasound receiver
US8709034B2 (en) 2011-05-13 2014-04-29 Broncus Medical Inc. Methods and devices for diagnosing, monitoring, or treating medical conditions through an opening through an airway wall
US8968280B2 (en) 2009-01-23 2015-03-03 The General Hospital Corporation Dose determination for inducing microcavitation in retinal pigment epithelium (RPE)
US20150359593A1 (en) * 2014-06-11 2015-12-17 The Spectranetics Corporation Convertible optical and pressure wave ablation system and method
US9345532B2 (en) 2011-05-13 2016-05-24 Broncus Medical Inc. Methods and devices for ablation of tissue
US20160183844A1 (en) * 2007-11-09 2016-06-30 The Spectranetics Corporation Intra-Vascular Device With Pressure Detection Capabilities Using Pressure Sensitive Material
US20160213256A1 (en) * 2015-01-22 2016-07-28 National Taiwan University System and imaging method for using photoacoustic effect
US9603741B2 (en) 2000-05-19 2017-03-28 Michael S. Berlin Delivery system and method of use for the eye
US9689661B2 (en) * 2013-12-03 2017-06-27 The General Hospital Corporation Apparatus and method to compensate for input polarization mode variation
US9826996B2 (en) * 2011-01-31 2017-11-28 Advanced Magnet Lab, Inc Systems and methods which remove material from blood vessel walls
WO2018014021A3 (fr) * 2016-07-15 2018-02-22 North Carolina State University Transducteur ultrasonore et réseau pour thrombolyse intravasculaire
US10064757B2 (en) 2011-05-05 2018-09-04 Michael S. Berlin Methods and apparatuses for the treatment of glaucoma using visible and infrared ultrashort laser pulses
US10272260B2 (en) 2011-11-23 2019-04-30 Broncus Medical Inc. Methods and devices for diagnosing, monitoring, or treating medical conditions through an opening through an airway wall
US10363168B2 (en) 2011-06-14 2019-07-30 Ivantis, Inc. Ocular implants for delivery into the eye
US10406025B2 (en) 2009-07-09 2019-09-10 Ivantis, Inc. Ocular implants and methods for delivering ocular implants into the eye
US10492949B2 (en) 2009-07-09 2019-12-03 Ivantis, Inc. Single operator device for delivering an ocular implant
US10537474B2 (en) 2008-03-05 2020-01-21 Ivantis, Inc. Methods and apparatus for treating glaucoma
US10709547B2 (en) 2014-07-14 2020-07-14 Ivantis, Inc. Ocular implant delivery system and method
US11026836B2 (en) 2012-04-18 2021-06-08 Ivantis, Inc. Ocular implants for delivery into an anterior chamber of the eye
US11135088B2 (en) 2011-12-19 2021-10-05 Ivantis Inc. Delivering ocular implants into the eye
US11197779B2 (en) 2015-08-14 2021-12-14 Ivantis, Inc. Ocular implant with pressure sensor and delivery system
US20220133273A1 (en) * 2019-02-11 2022-05-05 The Penn State Research Foundation Transparent ultrasound transducers for photoacoustic imaging
US11406452B2 (en) * 2018-06-04 2022-08-09 Pavel V. Efremkin Laser device for vascular and intrabody surgery and method of use
US20220280237A1 (en) * 2018-06-04 2022-09-08 Pavel V. Efremkin Laser device for vascular and intrabody surgery and method of use
US11485994B2 (en) 2012-10-04 2022-11-01 The University Of North Carolina At Chapel Hill Methods and systems for using encapsulated microbubbles to process biological samples
US11540940B2 (en) 2021-01-11 2023-01-03 Alcon Inc. Systems and methods for viscoelastic delivery
US11712369B2 (en) 2012-11-28 2023-08-01 Alcon Inc. Apparatus for delivering ocular implants into an anterior chamber of the eye
US11744734B2 (en) 2007-09-24 2023-09-05 Alcon Inc. Method of implanting an ocular implant
US11832877B2 (en) 2017-04-03 2023-12-05 Broncus Medical Inc. Electrosurgical access sheath
US11938058B2 (en) 2015-12-15 2024-03-26 Alcon Inc. Ocular implant and delivery system
US12029683B2 (en) 2018-02-22 2024-07-09 Alcon Inc. Ocular implant and delivery system
US12226309B2 (en) 2013-03-15 2025-02-18 Alcon Inc. Intraocular lens storage and loading devices and methods of use
US12245930B2 (en) 2023-06-30 2025-03-11 Alcon Inc. System and methods for compensating for intraocular lens tilt
US12318279B2 (en) 2007-07-23 2025-06-03 Alcon Inc. Lens delivery system
US12419738B2 (en) 2010-02-23 2025-09-23 Alcon Inc. Fluid for accommodating intraocular lenses
WO2025213246A1 (fr) * 2024-04-11 2025-10-16 Profound Medical Inc. Applicateur d'ultrasons avec laser

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06509952A (ja) * 1991-08-22 1994-11-10 ディ・ビアッジョ、ロベルト・エンツォ 医用光治療装置
US6302875B1 (en) 1996-10-11 2001-10-16 Transvascular, Inc. Catheters and related devices for forming passageways between blood vessels or other anatomical structures
RU2177355C2 (ru) * 1999-12-29 2001-12-27 Вахрушев Сергей Геннадьевич Устройство для подведения лазерного излучения к тканям верхних дыхательных путей
GB2436066A (en) * 2006-03-17 2007-09-19 David Groves Catheter having electromagnetic ablation means and plural, symmetric ultrasonic transducers

Citations (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3532181A (en) * 1967-06-01 1970-10-06 United Aircraft Corp Laser induced acoustic generator
US4086484A (en) * 1976-07-14 1978-04-25 International Telephone And Telegraph Corporation Optical amplitude modulation modulator
US4169662A (en) * 1977-02-24 1979-10-02 Krautkramer-Branson, Incorporated Method and apparatus for producing acoustic waves by laser pulses
US4405198A (en) * 1981-08-25 1983-09-20 The United States Of America As Represented By The Secretary Of The Navy Extended fiber optic sensor using birefringent fibers
US4530078A (en) * 1982-06-11 1985-07-16 Nicholas Lagakos Microbending fiber optic acoustic sensor
US4558706A (en) * 1982-03-05 1985-12-17 Olympus Optical Co., Ltd. Device for diagnosing body cavity interiors with ultrasonic waves
US4576177A (en) * 1983-02-18 1986-03-18 Webster Wilton W Jr Catheter for removing arteriosclerotic plaque
US4587972A (en) * 1984-07-16 1986-05-13 Morantte Jr Bernardo D Device for diagnostic and therapeutic intravascular intervention
DE3600713A1 (de) * 1985-01-14 1986-07-17 Heinz Dr. Graz Schmidt-Kloiber Einrichtung zur zerstoerung von harnwegkonkrementen
DE3506249A1 (de) * 1985-02-22 1986-08-28 Messerschmitt-Bölkow-Blohm GmbH, 8012 Ottobrunn Verfahren und vorrichtung zur zertruemmerung eines festen koerpers
US4637401A (en) * 1984-11-01 1987-01-20 Johnston G Gilbert Volumetric flow rate determination in conduits not directly accessible
US4641650A (en) * 1985-03-11 1987-02-10 Mcm Laboratories, Inc. Probe-and-fire lasers
US4665925A (en) * 1985-09-13 1987-05-19 Pfizer Hospital Products Group, Inc. Doppler catheter
US4666308A (en) * 1984-10-30 1987-05-19 Stanford University Method and apparatus for non-destructive testing using acoustic-optic laser probe
US4726651A (en) * 1982-01-21 1988-02-23 Minnesota Mining And Manufacturing Company Optical fibers having piezoelectric coatings
US4730093A (en) * 1984-10-01 1988-03-08 General Electric Company Method and apparatus for repairing metal in an article
DE3736953A1 (de) * 1986-11-13 1988-05-26 Messerschmitt Boelkow Blohm Vorrichtung zur zertruemmerung eines von einem fluid umgebenen festen koerpers
US4759613A (en) * 1985-08-19 1988-07-26 U.S. Philips Corp. Acousto-optic modulator
US4785806A (en) * 1987-01-08 1988-11-22 Yale University Laser ablation process and apparatus
US4794931A (en) * 1986-02-28 1989-01-03 Cardiovascular Imaging Systems, Inc. Catheter apparatus, system and method for intravascular two-dimensional ultrasonography
WO1989004143A1 (fr) * 1987-10-27 1989-05-18 Endosonics Appareil et procede d'imagerie de petites cavites
US4841977A (en) * 1987-05-26 1989-06-27 Inter Therapy, Inc. Ultra-thin acoustic transducer and balloon catheter using same in imaging array subassembly
US4844585A (en) * 1987-03-05 1989-07-04 University Of Strathclyde Optically excited vibratile transducer
US5041121A (en) * 1988-12-21 1991-08-20 Messerschmitt-Bolkow-Blohm Gmbh Shock wave generator

Patent Citations (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3532181A (en) * 1967-06-01 1970-10-06 United Aircraft Corp Laser induced acoustic generator
US4086484A (en) * 1976-07-14 1978-04-25 International Telephone And Telegraph Corporation Optical amplitude modulation modulator
US4169662A (en) * 1977-02-24 1979-10-02 Krautkramer-Branson, Incorporated Method and apparatus for producing acoustic waves by laser pulses
US4405198A (en) * 1981-08-25 1983-09-20 The United States Of America As Represented By The Secretary Of The Navy Extended fiber optic sensor using birefringent fibers
US4726651A (en) * 1982-01-21 1988-02-23 Minnesota Mining And Manufacturing Company Optical fibers having piezoelectric coatings
US4558706A (en) * 1982-03-05 1985-12-17 Olympus Optical Co., Ltd. Device for diagnosing body cavity interiors with ultrasonic waves
US4530078A (en) * 1982-06-11 1985-07-16 Nicholas Lagakos Microbending fiber optic acoustic sensor
US4576177A (en) * 1983-02-18 1986-03-18 Webster Wilton W Jr Catheter for removing arteriosclerotic plaque
US4587972A (en) * 1984-07-16 1986-05-13 Morantte Jr Bernardo D Device for diagnostic and therapeutic intravascular intervention
US4730093A (en) * 1984-10-01 1988-03-08 General Electric Company Method and apparatus for repairing metal in an article
US4666308A (en) * 1984-10-30 1987-05-19 Stanford University Method and apparatus for non-destructive testing using acoustic-optic laser probe
US4637401A (en) * 1984-11-01 1987-01-20 Johnston G Gilbert Volumetric flow rate determination in conduits not directly accessible
DE3600713A1 (de) * 1985-01-14 1986-07-17 Heinz Dr. Graz Schmidt-Kloiber Einrichtung zur zerstoerung von harnwegkonkrementen
DE3506249A1 (de) * 1985-02-22 1986-08-28 Messerschmitt-Bölkow-Blohm GmbH, 8012 Ottobrunn Verfahren und vorrichtung zur zertruemmerung eines festen koerpers
US4641650A (en) * 1985-03-11 1987-02-10 Mcm Laboratories, Inc. Probe-and-fire lasers
US4759613A (en) * 1985-08-19 1988-07-26 U.S. Philips Corp. Acousto-optic modulator
US4665925A (en) * 1985-09-13 1987-05-19 Pfizer Hospital Products Group, Inc. Doppler catheter
US4794931A (en) * 1986-02-28 1989-01-03 Cardiovascular Imaging Systems, Inc. Catheter apparatus, system and method for intravascular two-dimensional ultrasonography
DE3736953A1 (de) * 1986-11-13 1988-05-26 Messerschmitt Boelkow Blohm Vorrichtung zur zertruemmerung eines von einem fluid umgebenen festen koerpers
US4932954A (en) * 1986-11-13 1990-06-12 Messerschmitt-Bolkow-Blohm Gmbh Apparatus for fragmentation of a solid body surrounded by a fluid
US4785806A (en) * 1987-01-08 1988-11-22 Yale University Laser ablation process and apparatus
US4844585A (en) * 1987-03-05 1989-07-04 University Of Strathclyde Optically excited vibratile transducer
US4841977A (en) * 1987-05-26 1989-06-27 Inter Therapy, Inc. Ultra-thin acoustic transducer and balloon catheter using same in imaging array subassembly
WO1989004143A1 (fr) * 1987-10-27 1989-05-18 Endosonics Appareil et procede d'imagerie de petites cavites
US5041121A (en) * 1988-12-21 1991-08-20 Messerschmitt-Bolkow-Blohm Gmbh Shock wave generator

Non-Patent Citations (13)

* Cited by examiner, † Cited by third party
Title
H. M. Ledbetter et al. "Laser Induced Rayleigh Waved in Aluminum," J. Acoust. Soc. Am., vol. 65, No. 3, Mar. 1979, pp. 840-842.
H. M. Ledbetter et al. Laser Induced Rayleigh Waved in Aluminum, J. Acoust. Soc. Am., vol. 65, No. 3, Mar. 1979, pp. 840 842. *
J. A. Vogel et al., "Beam Steering of Laser Gnerated Ultrasound," Ultrasonics International 87 Conf. Proc., pp. 141-152.
J. A. Vogel et al., Beam Steering of Laser Gnerated Ultrasound, Ultrasonics International 87 Conf. Proc., pp. 141 152. *
L. S. Gournay, "Conversion of Electromagnetic To Acoustic Energy by Surface Heating," J. Acoust. Soc. Am., vol. 40, No. 6, 1966, pp. 1322-1330.
L. S. Gournay, Conversion of Electromagnetic To Acoustic Energy by Surface Heating, J. Acoust. Soc. Am., vol. 40, No. 6, 1966, pp. 1322 1330. *
O. B. Ovchinnikov et al., "Recording of the Space-Time Characteristics of Short Acoustic Pulses Generated by Optical Irradiation," Sov. Phys. Acoust., vol. 33, No. 2, Mar.-Apr. 1987, pp. 182-184.
O. B. Ovchinnikov et al., Recording of the Space Time Characteristics of Short Acoustic Pulses Generated by Optical Irradiation, Sov. Phys. Acoust., vol. 33, No. 2, Mar. Apr. 1987, pp. 182 184. *
R. C. Addison, Jr. et al. "Synthesis of an Ultrasonic Array Using Laser-Based Techniques," 1987 Ultrasonics Symp., pp. 1109-1113.
R. C. Addison, Jr. et al. Synthesis of an Ultrasonic Array Using Laser Based Techniques, 1987 Ultrasonics Symp., pp. 1109 1113. *
Scruby, Some Applications of Laser Ultrasound, Ultrasonics, Jul. 1989, vol. 27. *
Wang et al., "CO2 Laser-Generated Acoustic Wave in Aluminum," J. App. Phys., Jul. 1, 1989, vol. 66.
Wang et al., CO 2 Laser Generated Acoustic Wave in Aluminum, J. App. Phys., Jul. 1, 1989, vol. 66. *

Cited By (208)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5464013A (en) * 1984-05-25 1995-11-07 Lemelson; Jerome H. Medical scanning and treatment system and method
US5916210A (en) * 1990-01-26 1999-06-29 Intraluminal Therapeutics, Inc. Catheter for laser treatment of atherosclerotic plaque and other tissue abnormalities
US5807389A (en) * 1991-08-16 1998-09-15 Myriadlase, Inc. Laterally reflecting tip for laser transmitting fiber
US6033371A (en) * 1991-10-03 2000-03-07 The General Hospital Corporation Apparatus and method for vasodilation
US6406486B1 (en) 1991-10-03 2002-06-18 The General Hospital Corporation Apparatus and method for vasodilation
US6230568B1 (en) 1992-02-07 2001-05-15 Ultrasonic Sensing And Monitoring Systems, Inc. Method and apparatus for ultrasonic inspection of inaccessible areas
US5468239A (en) * 1992-04-13 1995-11-21 Sorenson Laboratories, Inc. Apparatus and methods for using a circumferential light-emitting surgical laser probe
US5486170A (en) * 1992-10-26 1996-01-23 Ultrasonic Sensing And Monitoring Systems Medical catheter using optical fibers that transmit both laser energy and ultrasonic imaging signals
US5515850A (en) * 1993-06-07 1996-05-14 Hewlett-Packard Company Apparatus for coupling acoustic waves with an acoustic waveguide
US5718231A (en) * 1993-06-15 1998-02-17 British Technology Group Ltd. Laser ultrasound probe and ablator
US5601738A (en) * 1993-07-15 1997-02-11 Medizinisches Laserzentrum Lubeck Gmbh Method and apparatus for treating material with a laser
US5562619A (en) * 1993-08-19 1996-10-08 Boston Scientific Corporation Deflectable catheter
US5865800A (en) * 1993-08-19 1999-02-02 Boston Scientific Corporation Deflectable catheter
US5674217A (en) * 1993-10-01 1997-10-07 Wahlstrom; Dale A. Heart synchronized extractor for an implanted object
US5423806A (en) * 1993-10-01 1995-06-13 Medtronic, Inc. Laser extractor for an implanted object
US7169140B1 (en) 1994-02-22 2007-01-30 Boston Scientific Scimed, Inc. Methods of using an intravascular balloon catheter in combination with an angioscope
US5776127A (en) * 1994-10-13 1998-07-07 The General Hospital Corporation Two-pulse, lateral tissue illuminator
US5738666A (en) * 1995-03-16 1998-04-14 Medtronic, Inc. Slit tip ventricular catheter and method of manufacturing same
EP0821567A4 (fr) * 1995-04-17 1999-07-28 W Gregory Chernoff Procede chirurgical
US6135994A (en) * 1995-04-17 2000-10-24 Chernoff; W. Gregory Surgical method
US5967984A (en) * 1995-06-30 1999-10-19 Boston Scientific Corporation Ultrasound imaging catheter with a cutting element
US6405069B1 (en) 1996-01-31 2002-06-11 Board Of Regents, The University Of Texas System Time-resolved optoacoustic method and system for noninvasive monitoring of glucose
US5840023A (en) * 1996-01-31 1998-11-24 Oraevsky; Alexander A. Optoacoustic imaging for medical diagnosis
US6309352B1 (en) 1996-01-31 2001-10-30 Board Of Regents, The University Of Texas System Real time optoacoustic monitoring of changes in tissue properties
US5733281A (en) * 1996-03-19 1998-03-31 American Ablation Co., Inc. Ultrasound and impedance feedback system for use with electrosurgical instruments
US6022309A (en) * 1996-04-24 2000-02-08 The Regents Of The University Of California Opto-acoustic thrombolysis
US5944687A (en) * 1996-04-24 1999-08-31 The Regents Of The University Of California Opto-acoustic transducer for medical applications
US20020045890A1 (en) * 1996-04-24 2002-04-18 The Regents Of The University O F California Opto-acoustic thrombolysis
US6379325B1 (en) 1996-04-24 2002-04-30 The Regents Of The University Of California Opto-acoustic transducer for medical applications
US5876426A (en) * 1996-06-13 1999-03-02 Scimed Life Systems, Inc. System and method of providing a blood-free interface for intravascular light delivery
US7051738B2 (en) 1996-07-28 2006-05-30 Uri Oron Apparatus for providing electromagnetic biostimulation of tissue using optics and echo imaging
US6395016B1 (en) 1996-07-28 2002-05-28 Biosense, Inc. Method of treating a heart using cells irradiated in vitro with biostimulatory irradiation
US6443974B1 (en) 1996-07-28 2002-09-03 Biosense, Inc. Electromagnetic cardiac biostimulation
US6086534A (en) * 1997-03-07 2000-07-11 Cardiogenesis Corporation Apparatus and method of myocardial revascularization using ultrasonic pulse-echo distance ranging
US6200307B1 (en) 1997-05-22 2001-03-13 Illumenex Corporation Treatment of in-stent restenosis using cytotoxic radiation
US6520957B1 (en) 1997-05-22 2003-02-18 Michael Kasinkas Treatment of in-stent restenosis using cytotoxic radiation
US6538739B1 (en) 1997-09-30 2003-03-25 The Regents Of The University Of California Bubble diagnostics
US6066127A (en) * 1997-09-30 2000-05-23 Nidek Co., Ltd. Laser treatment apparatus
US20050021013A1 (en) * 1997-10-21 2005-01-27 Endo Vasix, Inc. Photoacoustic removal of occlusions from blood vessels
US6368318B1 (en) 1998-01-23 2002-04-09 The Regents Of The University Of California Opto-acoustic recanilization delivery system
US8926519B2 (en) * 1998-03-05 2015-01-06 Vascular Imaging Corporation Opitcal-acoustic imaging device
US20080119739A1 (en) * 1998-03-05 2008-05-22 Vascular Imaging Corporation Optical-acoustic imaging device
US20040082844A1 (en) * 1998-03-05 2004-04-29 Vardi Gil M. Optical-acoustic imaging device
US7527594B2 (en) * 1998-03-05 2009-05-05 Vascular Imaging Corporation Optical-acoustic imaging device
US9532766B2 (en) 1998-03-05 2017-01-03 Vascular Imaging Corporation Optical-acoustic imaging device
US6869429B2 (en) * 1999-07-20 2005-03-22 Ajoy Inder Singh Apparatus for exterior arterial ablation
US6669686B1 (en) * 1999-07-20 2003-12-30 Ajoy Inder Singh Method and apparatus for arterial ablation
US20040111085A1 (en) * 1999-07-20 2004-06-10 Singh Ajoy Inder Method and apparatus for arterial ablation
US7422563B2 (en) 1999-08-05 2008-09-09 Broncus Technologies, Inc. Multifunctional tip catheter for applying energy to tissue and detecting the presence of blood flow
US7393330B2 (en) 1999-08-05 2008-07-01 Broncus Technologies, Inc. Electrosurgical device having hollow tissue cutting member and transducer assembly
US7815590B2 (en) 1999-08-05 2010-10-19 Broncus Technologies, Inc. Devices for maintaining patency of surgically created channels in tissue
US6498942B1 (en) 1999-08-06 2002-12-24 The University Of Texas System Optoacoustic monitoring of blood oxygenation
US6673064B1 (en) 2000-01-04 2004-01-06 Peter Rentrop Excimer laser catheter
US6440125B1 (en) 2000-01-04 2002-08-27 Peter Rentrop Excimer laser catheter
US7811281B1 (en) 2000-01-04 2010-10-12 Peter Rentrop Excimer laser catheter
US6475210B1 (en) * 2000-02-11 2002-11-05 Medventure Technology Corp Light treatment of vulnerable atherosclerosis plaque
US20040002679A1 (en) * 2000-02-15 2004-01-01 Hugh Trout Apparatus and method for performing a surgical procedure
US7101366B2 (en) 2000-02-15 2006-09-05 Eva Corporation Apparatus and method for performing a surgical procedure
US6751490B2 (en) 2000-03-01 2004-06-15 The Board Of Regents Of The University Of Texas System Continuous optoacoustic monitoring of hemoglobin concentration and hematocrit
US20040082939A1 (en) * 2000-05-19 2004-04-29 Berlin Michael S. Delivery system and method of use for the eye
US9833357B2 (en) 2000-05-19 2017-12-05 Michael S. Berlin Delivery system and method of use for the eye
US10390993B1 (en) 2000-05-19 2019-08-27 Ivantis, Inc. Delivery system and method of use for the eye
US20020013572A1 (en) * 2000-05-19 2002-01-31 Berlin Michael S. Delivery system and method of use for the eye
US10687978B2 (en) 2000-05-19 2020-06-23 Ivantis, Inc. Delivery system and method of use for the eye
US9603741B2 (en) 2000-05-19 2017-03-28 Michael S. Berlin Delivery system and method of use for the eye
US10159601B2 (en) 2000-05-19 2018-12-25 Ivantis, Inc. Delivery system and method of use for the eye
US10195080B2 (en) 2000-05-19 2019-02-05 Michael S. Berlin Glaucoma surgery methods and systems
US9820883B2 (en) 2000-05-19 2017-11-21 Michael S. Berlin Method for treating glaucoma
US10383689B2 (en) * 2000-05-19 2019-08-20 Michael S. Berlin Delivery system and method of use for the eye
US10335314B2 (en) 2000-05-19 2019-07-02 Ivantis, Inc. Delivery system and method of use for the eye
US20060259022A1 (en) * 2000-06-01 2006-11-16 The General Hospital Corporation, A Massachusetts Corporation Selective photocoagulation
US8006702B2 (en) 2000-06-01 2011-08-30 The General Hospital Corporation Selective photocoagulation
USRE46493E1 (en) 2000-06-01 2017-08-01 The General Hospital Corporation Selective photocoagulation
US8366704B2 (en) 2000-06-01 2013-02-05 The General Hospital Corporation Optical devices and methods for selective and conventional photocoagulation of the retinal pigment epithelium
US7947036B2 (en) 2000-06-01 2011-05-24 The General Hospital Corporation Selective photocoagulation
US20080259422A1 (en) * 2000-06-01 2008-10-23 The General Hospital Corporation Selective photocoagulation
US20060161145A1 (en) * 2000-06-01 2006-07-20 Massachusetts General Hospital Optical devices and methods for selective and conventional photocoagulation of the retinal pigment epithelium
US20080281306A1 (en) * 2000-06-01 2008-11-13 The General Hospital Corporation Selective photocoagulation
US8187257B2 (en) 2000-06-01 2012-05-29 The General Hospital Corporation Optical devices and methods for selective and conventional photocoagulation of the retinal pigment epithelium
US20040039378A1 (en) * 2000-06-01 2004-02-26 Lin Charles P. Selective photocoagulation
US7763017B2 (en) * 2000-06-01 2010-07-27 The General Hospital Corporation Selective photocoagulation apparatus
US7115120B2 (en) * 2000-06-01 2006-10-03 The General Hospital Corporation Selective photocoagulation
US6576000B2 (en) 2001-03-06 2003-06-10 Scimed Life Systems, Inc. Devices and methods for tissue repair
WO2002069824A1 (fr) * 2001-03-06 2002-09-12 Scimed Life Systems, Inc. Dispositifs et methodes de reparation tissulaire
US8679089B2 (en) 2001-05-21 2014-03-25 Michael S. Berlin Glaucoma surgery methods and systems
US20080082078A1 (en) * 2001-05-21 2008-04-03 Eyelight, Inc. Glaucoma surgery methods and systems
US9642746B2 (en) 2001-05-21 2017-05-09 Michael Berlin Glaucoma surgery methods and systems
US7462162B2 (en) 2001-09-04 2008-12-09 Broncus Technologies, Inc. Antiproliferative devices for maintaining patency of surgically created channels in a body organ
US7708712B2 (en) 2001-09-04 2010-05-04 Broncus Technologies, Inc. Methods and devices for maintaining patency of surgically created channels in a body organ
WO2003057061A1 (fr) 2002-01-08 2003-07-17 Bio Scan Ltd. Sonde de transducteur ultrasonique
EP1665998A2 (fr) 2002-01-08 2006-06-07 Bio Scan Ltd. Sonde de transducteur ultrasonique
US20050131289A1 (en) * 2002-01-08 2005-06-16 Bio Scan Ltd Ultrasonic transducer probe
EP1485035A4 (fr) * 2002-02-21 2006-05-31 Broncus Tech Inc Dispositifs destines a appliquer de l'energie sur un tissu
WO2003103473A3 (fr) * 2002-04-11 2004-04-01 Eva Corp Appareil et procede pour intervention chirurgicale
US8059923B2 (en) 2002-10-07 2011-11-15 Vascular Imaging Corporation Systems and methods for minimally-invasive optical-acoustic imaging
US20100135111A1 (en) * 2002-10-07 2010-06-03 Vascular Imaging Corporation Systems and methods for minimally-invasive optical-acoustic imaging
US20040067000A1 (en) * 2002-10-07 2004-04-08 Bates Kenneth N. Systems and methods for minimally-invasive optical-acoustic imaging
US7660492B2 (en) 2002-10-07 2010-02-09 Vascular Imaging Corporation Systems and methods for minimally-invasive optical-acoustic imaging
US8391652B2 (en) 2002-10-07 2013-03-05 Vascular Imaging Corporation Systems and methods for minimally-invasive optical-acoustic imaging
US7245789B2 (en) 2002-10-07 2007-07-17 Vascular Imaging Corporation Systems and methods for minimally-invasive optical-acoustic imaging
US7447388B2 (en) 2002-10-07 2008-11-04 Vascular Imaging Corporation Systems and methods for minimally-invasive optical-acoustic imaging
US9339192B2 (en) 2002-10-07 2016-05-17 Vascular Imaging Corporation Systems and methods for minimally-invasive optical-acoustic imaging
US20090059727A1 (en) * 2002-10-07 2009-03-05 Vascular Imaging Corporation Systems and methods for minimally-invasive optical-acoustic imaging
US8731340B2 (en) 2002-10-07 2014-05-20 Vascular Imaging Corporation Systems and methods for minimally-invasive optical-acoustic imaging
US9192307B2 (en) 2002-10-07 2015-11-24 Vascular Imaging Corporation Systems and methods for minimally-invasive optical-acoustic imaging
WO2004034878A3 (fr) * 2002-10-17 2005-04-28 Iridex Corp Dispositif d'emission laser contenant une pluralite de fibres optiques de source laser
US20050055015A1 (en) * 2002-10-17 2005-03-10 Buzawa David M. Laser delivery device incorporationg a plurality of laser source optical fibers
KR101110398B1 (ko) * 2003-04-03 2012-02-17 세람옵텍 인더스트리스, 인크. 출력이 조절되는 의료용 피하 조사 치료 시스템
WO2004089462A3 (fr) * 2003-04-03 2005-11-24 Ceramoptec Ind Inc Systeme de traitement par irradiation medicale sous-cutanee a regulation de puissance
US20040199151A1 (en) * 2003-04-03 2004-10-07 Ceramoptec Industries, Inc. Power regulated medical underskin irradiation treament system
US20070123776A1 (en) * 2003-04-09 2007-05-31 Rami Aharoni Ultrasonic probing device with distributed sensing elements
EP1615562A4 (fr) * 2003-04-09 2007-08-22 Bioscan Ltd Dispositif de detection par ultrason avec des elements de detection repartis
US7430445B2 (en) 2003-04-24 2008-09-30 The Board Of Regents Of The University Of Texas System Noninvasive blood analysis by optical probing of the veins under the tongue
US8352005B2 (en) 2003-04-24 2013-01-08 Board Of Regents, The University Of Texas System Noninvasive blood analysis by optical probing of the veins under the tongue
US20080281173A1 (en) * 2003-04-24 2008-11-13 The Board Of Regents Of The University Of Texas System Noninvasive blood analysis by optical probing of the veins under the tongue
US20060195021A1 (en) * 2003-04-24 2006-08-31 Esenal Rinat O Noninvasive blood analysis by optical probing of the veins under the tongue
US8308682B2 (en) 2003-07-18 2012-11-13 Broncus Medical Inc. Devices for maintaining patency of surgically created channels in tissue
US9533128B2 (en) 2003-07-18 2017-01-03 Broncus Medical Inc. Devices for maintaining patency of surgically created channels in tissue
US8002740B2 (en) 2003-07-18 2011-08-23 Broncus Technologies, Inc. Devices for maintaining patency of surgically created channels in tissue
US8608724B2 (en) 2004-07-19 2013-12-17 Broncus Medical Inc. Devices for delivering substances through an extra-anatomic opening created in an airway
US8409167B2 (en) 2004-07-19 2013-04-02 Broncus Medical Inc Devices for delivering substances through an extra-anatomic opening created in an airway
US8784400B2 (en) 2004-07-19 2014-07-22 Broncus Medical Inc. Devices for delivering substances through an extra-anatomic opening created in an airway
US10369339B2 (en) 2004-07-19 2019-08-06 Broncus Medical Inc. Devices for delivering substances through an extra-anatomic opening created in an airway
US11357960B2 (en) 2004-07-19 2022-06-14 Broncus Medical Inc. Devices for delivering substances through an extra-anatomic opening created in an airway
US8320723B2 (en) 2005-11-22 2012-11-27 Vascular Imaging Corporation Optical imaging probe connector
US20130148933A1 (en) * 2005-11-22 2013-06-13 Vascular Imaging Corporation Optical imaging probe
US20150045645A1 (en) * 2005-11-22 2015-02-12 Vascular Imaging Corporation Optical imaging probe
US9198581B2 (en) * 2005-11-22 2015-12-01 Vascular Imaging Corporation Optical imaging probe
US20160097904A1 (en) * 2005-11-22 2016-04-07 Vascular Imaging Corporation Optical imaging probe
US8861908B2 (en) * 2005-11-22 2014-10-14 Vascular Imaging Corporation Optical imaging probe
US20070116408A1 (en) * 2005-11-22 2007-05-24 Eberle Michael J Optical imaging probe connector
US7599588B2 (en) 2005-11-22 2009-10-06 Vascular Imaging Corporation Optical imaging probe connector
US7881573B2 (en) 2005-11-22 2011-02-01 Vascular Imaging Corporation Optical imaging probe connector
US20100014810A1 (en) * 2005-11-22 2010-01-21 Vascular Imaging Corporation Optical imaging probe connector
US9557490B2 (en) * 2005-11-22 2017-01-31 Vascular Imaging Corporation Optical imaging probe
US20090054763A1 (en) * 2006-01-19 2009-02-26 The Regents Of The University Of Michigan System and method for spectroscopic photoacoustic tomography
US9913969B2 (en) 2006-10-05 2018-03-13 Broncus Medical Inc. Devices for delivering substances through an extra-anatomic opening created in an airway
US20080123083A1 (en) * 2006-11-29 2008-05-29 The Regents Of The University Of Michigan System and Method for Photoacoustic Guided Diffuse Optical Imaging
US20080173093A1 (en) * 2007-01-18 2008-07-24 The Regents Of The University Of Michigan System and method for photoacoustic tomography of joints
US20080221647A1 (en) * 2007-02-23 2008-09-11 The Regents Of The University Of Michigan System and method for monitoring photodynamic therapy
US20150251942A1 (en) * 2007-06-15 2015-09-10 Vesuvius Crucible Company High-temperature roll
US20100218559A1 (en) * 2007-06-15 2010-09-02 Vesuvius Crucible Company High temperature roll
US9695078B2 (en) * 2007-06-15 2017-07-04 Vesuvius Crucible Company High-temperature roll
US12318279B2 (en) 2007-07-23 2025-06-03 Alcon Inc. Lens delivery system
US12016796B2 (en) 2007-09-24 2024-06-25 Alcon Inc. Methods and devices for increasing aqueous humor outflow
US11744734B2 (en) 2007-09-24 2023-09-05 Alcon Inc. Method of implanting an ocular implant
US11166647B2 (en) * 2007-11-09 2021-11-09 The Spectranetics Corporation Intra-vascular device with pressure detection capabilities using pressure sensitive material
US20160183844A1 (en) * 2007-11-09 2016-06-30 The Spectranetics Corporation Intra-Vascular Device With Pressure Detection Capabilities Using Pressure Sensitive Material
US10537474B2 (en) 2008-03-05 2020-01-21 Ivantis, Inc. Methods and apparatus for treating glaucoma
US11504275B2 (en) 2008-03-05 2022-11-22 Alcon Inc. Methods and apparatus for treating glaucoma
US9579026B2 (en) 2008-10-02 2017-02-28 Vascular Imaging Corporation Optical ultrasound receiver
US8560048B2 (en) 2008-10-02 2013-10-15 Vascular Imaging Corporation Optical ultrasound receiver
US9078561B2 (en) 2008-10-02 2015-07-14 Vascular Imaging Corporation Optical ultrasound receiver
US8968280B2 (en) 2009-01-23 2015-03-03 The General Hospital Corporation Dose determination for inducing microcavitation in retinal pigment epithelium (RPE)
US11596546B2 (en) 2009-07-09 2023-03-07 Alcon Inc. Ocular implants and methods for delivering ocular implants into the eye
US10406025B2 (en) 2009-07-09 2019-09-10 Ivantis, Inc. Ocular implants and methods for delivering ocular implants into the eye
US11918514B2 (en) 2009-07-09 2024-03-05 Alcon Inc. Single operator device for delivering an ocular implant
US10492949B2 (en) 2009-07-09 2019-12-03 Ivantis, Inc. Single operator device for delivering an ocular implant
US11464675B2 (en) 2009-07-09 2022-10-11 Alcon Inc. Single operator device for delivering an ocular implant
US12409067B2 (en) 2009-07-09 2025-09-09 Alcon Inc. Single operator device for delivering an ocular implant
US12419738B2 (en) 2010-02-23 2025-09-23 Alcon Inc. Fluid for accommodating intraocular lenses
US9826996B2 (en) * 2011-01-31 2017-11-28 Advanced Magnet Lab, Inc Systems and methods which remove material from blood vessel walls
US11510813B2 (en) 2011-05-05 2022-11-29 Michael S. Berlin Methods and apparatuses for the treatment of glaucoma using visible and infrared ultrashort laser pulses
US10064757B2 (en) 2011-05-05 2018-09-04 Michael S. Berlin Methods and apparatuses for the treatment of glaucoma using visible and infrared ultrashort laser pulses
US12329684B2 (en) 2011-05-05 2025-06-17 Michael S. Berlin Systems for the treatment of glaucoma using visible and infrared ultrashort laser pulses
US10765559B2 (en) 2011-05-05 2020-09-08 Michael S. Berlin Methods and apparatuses for the treatment of glaucoma using visible and infrared ultrashort laser pulses
US11857463B2 (en) 2011-05-05 2024-01-02 Michael S. Berlin Methods for the treatment of glaucoma using visible and infrared ultrashort laser pulses
US11039958B2 (en) 2011-05-05 2021-06-22 Michael S. Berlin Methods and apparatuses for the treatment of glaucoma using visible and infrared ultrashort laser pulses
US11974950B2 (en) 2011-05-05 2024-05-07 Michael S. Berlin Methods and systems for the treatment of glaucoma using visible and infrared ultrashort laser pulses
US9993306B2 (en) 2011-05-13 2018-06-12 Broncus Medical Inc. Methods and devices for diagnosing, monitoring, or treating medical conditions through an opening through an airway wall
US12016640B2 (en) 2011-05-13 2024-06-25 Broncus Medical Inc. Methods and devices for diagnosing, monitoring, or treating medical conditions through an opening through an airway wall
US9486229B2 (en) 2011-05-13 2016-11-08 Broncus Medical Inc. Methods and devices for excision of tissue
US10631938B2 (en) 2011-05-13 2020-04-28 Broncus Medical Inc. Methods and devices for diagnosing, monitoring, or treating medical conditions through an opening through an airway wall
US9421070B2 (en) 2011-05-13 2016-08-23 Broncus Medical Inc. Methods and devices for diagnosing, monitoring, or treating medical conditions through an opening through an airway wall
US8932316B2 (en) 2011-05-13 2015-01-13 Broncus Medical Inc. Methods and devices for diagnosing, monitoring, or treating medical conditions through an opening through an airway wall
US9345532B2 (en) 2011-05-13 2016-05-24 Broncus Medical Inc. Methods and devices for ablation of tissue
US8709034B2 (en) 2011-05-13 2014-04-29 Broncus Medical Inc. Methods and devices for diagnosing, monitoring, or treating medical conditions through an opening through an airway wall
US10363168B2 (en) 2011-06-14 2019-07-30 Ivantis, Inc. Ocular implants for delivery into the eye
US10272260B2 (en) 2011-11-23 2019-04-30 Broncus Medical Inc. Methods and devices for diagnosing, monitoring, or treating medical conditions through an opening through an airway wall
US12076273B2 (en) 2011-12-19 2024-09-03 Alcon Inc. Delivering ocular implants into the eye
US11135088B2 (en) 2011-12-19 2021-10-05 Ivantis Inc. Delivering ocular implants into the eye
US11992437B2 (en) 2012-04-18 2024-05-28 Alcon Inc. Ocular implants for delivery into an anterior chamber of the eye
US11026836B2 (en) 2012-04-18 2021-06-08 Ivantis, Inc. Ocular implants for delivery into an anterior chamber of the eye
US11485994B2 (en) 2012-10-04 2022-11-01 The University Of North Carolina At Chapel Hill Methods and systems for using encapsulated microbubbles to process biological samples
US12376988B2 (en) 2012-11-28 2025-08-05 Alcon Inc. Apparatus for delivering ocular implants into an anterior chamber of the eye
US11712369B2 (en) 2012-11-28 2023-08-01 Alcon Inc. Apparatus for delivering ocular implants into an anterior chamber of the eye
US12226309B2 (en) 2013-03-15 2025-02-18 Alcon Inc. Intraocular lens storage and loading devices and methods of use
US9689661B2 (en) * 2013-12-03 2017-06-27 The General Hospital Corporation Apparatus and method to compensate for input polarization mode variation
US20150359593A1 (en) * 2014-06-11 2015-12-17 The Spectranetics Corporation Convertible optical and pressure wave ablation system and method
US10149718B2 (en) * 2014-06-11 2018-12-11 The Spectranetics Corporation Convertible optical and pressure wave ablation system and method
US20190069952A1 (en) * 2014-06-11 2019-03-07 Koninklijke Philips N.V. Convertible optical and pressure wave ablation system and method
US10543043B2 (en) * 2014-06-11 2020-01-28 The Spectranetics Corporation Convertible optical and pressure wave ablation system and method
US10709547B2 (en) 2014-07-14 2020-07-14 Ivantis, Inc. Ocular implant delivery system and method
US10004405B2 (en) * 2015-01-22 2018-06-26 National Taiwan University System and imaging method for using photoacoustic effect
US20160213256A1 (en) * 2015-01-22 2016-07-28 National Taiwan University System and imaging method for using photoacoustic effect
US11197779B2 (en) 2015-08-14 2021-12-14 Ivantis, Inc. Ocular implant with pressure sensor and delivery system
US11938058B2 (en) 2015-12-15 2024-03-26 Alcon Inc. Ocular implant and delivery system
WO2018014021A3 (fr) * 2016-07-15 2018-02-22 North Carolina State University Transducteur ultrasonore et réseau pour thrombolyse intravasculaire
US11832877B2 (en) 2017-04-03 2023-12-05 Broncus Medical Inc. Electrosurgical access sheath
US12029683B2 (en) 2018-02-22 2024-07-09 Alcon Inc. Ocular implant and delivery system
US12023095B2 (en) * 2018-06-04 2024-07-02 Pavel V. Efremkin Laser device for vascular and intrabody surgery and method of use
US20220280237A1 (en) * 2018-06-04 2022-09-08 Pavel V. Efremkin Laser device for vascular and intrabody surgery and method of use
US11406452B2 (en) * 2018-06-04 2022-08-09 Pavel V. Efremkin Laser device for vascular and intrabody surgery and method of use
US20220133273A1 (en) * 2019-02-11 2022-05-05 The Penn State Research Foundation Transparent ultrasound transducers for photoacoustic imaging
US11540940B2 (en) 2021-01-11 2023-01-03 Alcon Inc. Systems and methods for viscoelastic delivery
US12336933B2 (en) 2021-01-11 2025-06-24 Alcon Inc. Systems and methods for viscoelastic delivery
US12245930B2 (en) 2023-06-30 2025-03-11 Alcon Inc. System and methods for compensating for intraocular lens tilt
WO2025213246A1 (fr) * 2024-04-11 2025-10-16 Profound Medical Inc. Applicateur d'ultrasons avec laser

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