US3271396A - Pyrido-quinazoline derivatives - Google Patents
Pyrido-quinazoline derivatives Download PDFInfo
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- US3271396A US3271396A US390215A US39021564A US3271396A US 3271396 A US3271396 A US 3271396A US 390215 A US390215 A US 390215A US 39021564 A US39021564 A US 39021564A US 3271396 A US3271396 A US 3271396A
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- lower alkyl
- amino
- pyrido
- piperazinyl
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Definitions
- R is hydrogen, lower alkyl (e.g., methyl, ethyl and isopropyl), halogen (e.g., chlorine and fluorine), halomethyl (e.g., trifiuoromethyl), lower alkoxy (e.g., methoxy, ethoxy, propoxy and amyloxy), aryloxy (e.g., phenoxy), amino, or di (lower alkyl)amino (e.g., dimethylamino and diethylamino); and B is a basic nitrogen-containing radical such as amino, (lower alkyl)amino, di(lower alkyl)amino (e.g., dimethylamino and diethylamino), hydroxy(lower alkyl)amino, di[hydroxy(lower alkyl)]amino, halo(
- the preferred compounds of this invention are those of Formula I in which R is hydrogen, lower alkylene is ethylene, isopropylene or propylene, and B is di(lower a1kyl)amino.
- suitable acid-addition salts of the free 'bases of this invention include the mineral acid salts, such as the hydrohalides (e.g., hydrochloride, hydrobromide and hydroiodide), the sulfate and the phosphate; and organic acid salts, such as the citrate, tartrate, oxalate, ascorbate, acetate and succinate.
- the hydrohalides e.g., hydrochloride, hydrobromide and hydroiodide
- organic acid salts such as the citrate, tartrate, oxalate, ascorbate, acetate and succinate.
- Pharmacologically ac- 3,271,396 Patented Sept. 6, 1966 ceptable acids are, of course, employed where the salt form is prepared for therapeutic use.
- Suitable quaternary ammonium salts of the free bases of this invention include the lower alkyl halides (e.g., methyl chloride and methyl bromide), the lower alkyl sulfates (e.g., methosulfate), the aralkyl halides (e.g., benzyl chloride) and the aralkyl sulfates.
- the lower alkyl halides e.g., methyl chloride and methyl bromide
- the lower alkyl sulfates e.g., methosulfate
- the aralkyl halides e.g., benzyl chloride
- aralkyl sulfates e.g., benzyl chloride
- the compounds of this invention are physiologically active substances having hypotensive activity, and central nervous system depressive activity.
- the compounds of this invention can be administered to reduce blood pressure perorally in the usual perorally acceptable forms, such as tablets and capsules, the dosage for such treat ment being adjusted for the activity of the particular compound employed.
- the compounds of this invention are prepared by the process of this invention which comprises reducing a compound of the Formula II:
- bases can then be converted to either their acid-addition salts or quaternary ammonium salts in the usual manner by treating with the desired acid or quaternizing agent.
- the free base is released from the cooled aqueous acidic solution with solid potassium carbonate, and extracted into ether.
- the ethereal solution is dried over magnesium sulfate, filtered, and the ether removed by distillation leaving a residue of crude base weighing about 7 g.
- Rcactant (R is) Prod(uct Formed EXAMPLE 14 5- (3-N-melhylpiperazinopropyl) -5,5a,6,7,8,9-hexahydr0- 1 1Hpyrid0[2,1-b]quinazolin-1L0ne hydrochloride Following the procedure of Example 1, but substituting 3-(N-methylpiperazino)propyl chloride for the 3-dimethylaminopropyl chloride in step b, 5-(3-N-rnethylpiperazinopropyl) 5,5a,6,7,8,9 hexahydro 11H pyrido [2,1-b1quinazolin-1l-one hydrochloride is formed.
- Example Reactant Product 3 T)iethylamin opropyl 2-1 ⁇ 'Ietl1ylaminoethyl Z-Diethylarninoethyl. 2-Benzylamin0ethyl Z-PiperidiuoethyL l-Pyrrolidinobutyl. S-Homopiperidinopropy 2-(3-Piperidinyl)ethyl 3-(N-Phenylpiperazino)- ropyl. 3- N-(Z-HydroxyethyD- piperazino1propyl.
- (lower alkylene)-B and the pharmaceutically acceptable acid-addition and quaternary ammonium salts thereof, wherein R is selected from the group consisting of hydrogen, lower alkyl, halo- 5 gen. halomethyl, lower alkoxy, mononuclear aryloxy,
- B is a basic nitrogencontaining radical selected from the group consisting of amino, (lower alkyl)amino, di(lwer alkyl)amino, hydroxy(lower alkyl)amino, halo(lower alkyl)amino, di[hydroxy(lower alkyl)]amino, (lower alkyl)phenyl(lower alkyl)amino, piperidyl, (lower alkyl)piperidyl, cli(lower alkyl)piperidyl, homopiperidyl, pyrrolidyl, (lower alkyl) pyrrolidyl, di(lower alkyl)pyrrolidyl, piperazinyl, homopiperazinyl, (lower alkyl)piperazinyl, di(lower alkyl) piperazinyl, (lower alkoxy)piperazinyl, R-phenylpiperazinyl
- R is selected from the group consisting of hydrogen, lower alkyl, halogen, halomet-hyl, lower alkoxy, mononuclear aryloxy, amino and di(lower alkyl)amino.
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Description
United States Patent This invention relates to new chemical compounds, and more particularly, to compounds of the Formula I:
(lower alkylene)- B and pharmaceutically acceptable acid-addition and quaternary ammonium salts thereof, wherein R is hydrogen, lower alkyl (e.g., methyl, ethyl and isopropyl), halogen (e.g., chlorine and fluorine), halomethyl (e.g., trifiuoromethyl), lower alkoxy (e.g., methoxy, ethoxy, propoxy and amyloxy), aryloxy (e.g., phenoxy), amino, or di (lower alkyl)amino (e.g., dimethylamino and diethylamino); and B is a basic nitrogen-containing radical such as amino, (lower alkyl)amino, di(lower alkyl)amino (e.g., dimethylamino and diethylamino), hydroxy(lower alkyl)amino, di[hydroxy(lower alkyl)]amino, halo(lower alkyl)amino, di[hydroxy(lower alkyl)]amino, (lower alkyl)aralkylamino (e.g., methylphenethylamino) (e.g., benzylamino), piperidyl (e.g., piperidino), (lower alkyl) piperidyl (e.g., 2, 3 and 4-methylpiperidino), di(lower alkyl)piperidyl (e.g., 2,4-, 2,6- and 3,5-dimethylpiperidino); homopiperidyl; pyrrolidyl (e.g., pyrrolidino), (lower alkyl)pyrrolidyl, di(lower alkyl)pyrrolidyl, piperazinyl (e.g., piperazino), homopiperazinyl, (lower alkyl) piperazinyl, (e.g., N -methylpiperazino), di(lower alkyl) piperazinyl, (lower alkoxy)piperazinyl, arylpiperazinyl (e.g., R-substituted phenylpiperazino), such as 4-phenylpiperazino, aralkylpiperazinyl (e.g., Rsubstituted phenyl (lower alkyl)piperazino), such as benzylpiperazino and p-chloro-phenethylpiperazino, pyridylpiperazinyl [e.g., 4- (3-pyridyl)piperazino], pyridyl(lower alkyl)piperazinyl [e.g., 4 (3 pyridylmethyl)piperazino], (alkanoyloxylower alkyl)piperazinyl [e.g., 4-(2-acetoxyethyl)piperazino], (hydroxy-lower alkyl)piperazinyl [e.g., 4-(2- hydroxyethyl)piperazino], morpholinyl (e.g., morpholino), (lower alkyl)morpholinyl, di(lower alkyl)-morpholinyl, thiamorpholinyl (e.g., thiamorpholino), (lower alkyl)thiamorpholinyl and di(lower alkyl)thiamorpholinyl. The terms lower alkyl, lower alkoxy, and lower alkylene as employed herein, include both straight and branched chain radicals of less than eight carbon atoms.
The preferred compounds of this invention are those of Formula I in which R is hydrogen, lower alkylene is ethylene, isopropylene or propylene, and B is di(lower a1kyl)amino.
Examples of suitable acid-addition salts of the free 'bases of this invention include the mineral acid salts, such as the hydrohalides (e.g., hydrochloride, hydrobromide and hydroiodide), the sulfate and the phosphate; and organic acid salts, such as the citrate, tartrate, oxalate, ascorbate, acetate and succinate. Pharmacologically ac- 3,271,396 Patented Sept. 6, 1966 ceptable acids are, of course, employed where the salt form is prepared for therapeutic use.
Examples of suitable quaternary ammonium salts of the free bases of this invention include the lower alkyl halides (e.g., methyl chloride and methyl bromide), the lower alkyl sulfates (e.g., methosulfate), the aralkyl halides (e.g., benzyl chloride) and the aralkyl sulfates.
The compounds of this invention are physiologically active substances having hypotensive activity, and central nervous system depressive activity. The compounds of this invention can be administered to reduce blood pressure perorally in the usual perorally acceptable forms, such as tablets and capsules, the dosage for such treat ment being adjusted for the activity of the particular compound employed.
The compounds of this invention are prepared by the process of this invention which comprises reducing a compound of the Formula II:
N CH:
wherein R is as hereinbefore defined, with a reducing agent, such as sodium borohydride, to yield new intermediates of this invention of the Formula III:
N// CH: R t I CH CH:
N a II wherein R is as herein'before defined; converting these intermediates into their alkali metal derivatives, as by treating with a base such as an alkali metal hydride (e.g., sodium hydride) or sodium amide or an alkali metal alkoxide such as sodium ethoxide or potassium t-butoxide, and then treating the alkali metal derivatives with an amino (lower alkylene)halide (preferably chloride) of the formula: B-(lower alkylene) halide, wherein B is as hereinbefore defined, to yield the bases of this invention of the Formula I. These bases can then be converted to either their acid-addition salts or quaternary ammonium salts in the usual manner by treating with the desired acid or quaternizing agent.
In those instances where the compounds of Formula II are new, they can be prepared by the method described by Bohme et al. in Archiv. der Pharmazie, 294/66, 556 (1961), by reacting an anthranilamide of the formula:
it ll-C-NHz Nllg The following examples illustrate the invention (all temperatures being in centigracle):
EXAMPLE 1 5-(3-dimethylamin0propyl) -5,5a,6,7,8,9-hexahydr-1 1H- pyrido[2,1-b1quinazolin-1 l-one hydrochloride (a) PREPARATION OF 5,5a,6,7,8,9-HEXAHYDRO-11H- PYRIDO [2,1-11] -QUINAZOLIN-11-ONE A solution of 30 g. (0.15 mole) of 6,7,8,9-tetrahydro- 1lH-pyrido[2,1-b]-quinazolin-1l-one in 300 ml. of methanol is stirred at room temperature as 6.2 g. (0.16 mole) of sodium borohydride is added portionwise over a period of 20 minutes. The reaction temperature is maintained below 30 by external cooling when necessary. After remaining at room temperature overnight the methanol is removed by distillation at reduced pressure. The residue is taken up in an ether-chloroform mixture and washed with cold 3% hydrochloric acid, water, and dried over magnesium sulfate. After filtration, the solvents are removed by distillation and the residue is taken up in ether. A solid crystallizes from the ethereal solution and is collected by suction filtration. This product is recrystallized from toluene to give about 11 g. (33%) of material, M.P. about 133-134".
Analysis.-Calcd. for C H N O: N, 13.85; C, 71.24; H, 6.97. Found: N. 13.76; C, 71.31; H, 6.99.
(b) PREPARATION OF 5-(3-DIMETHYLAMINOPROPYL)- 5,5a.6,7,8.9- HEXAHYDRO-llH-PYRIDO12,1-b]-QUINAZO LIN-ll-ONE HYDROCHLORIDE A solution of'7.1 g. (0.035 mole) of 5,5a,6,7,8,9-
hexahydro-llH-pyrido[2,1-b]quinazolin-ll-one in 50 ml.
of dry N,N-dimethylformamide is added over a period of minutes to a stirred suspension of 1.68 g. (0.035 mole) of 50% sodium hydride in mineral oil dispersion in 200 ml. N,N-dimethylformarnide. After stirring 2 hours at room temperature the dark red reaction mixture is warmed to 90-95 for 2 /2 hours, or until the effervescence of hydrogen gas has stopped. After cooling to 30, 6 g. (50% excess) of 3-dimethylaminopropyl chloride in 25 ml. of dry N,N-dimethylformamide is added. After stirring for 30 minutes the reaction temperature is raised to 90-95 for 5 hours after which time the color has disappeared and a gray solid separates from solution on cooling. After filtration, the filtrate is concentrated by distillation under reduced pressure to remove most of the solvent. The residue is taken up in ether and the ethereal solution is extracted with 3% hydrochloric acid.
The free base is released from the cooled aqueous acidic solution with solid potassium carbonate, and extracted into ether. The ethereal solution is dried over magnesium sulfate, filtered, and the ether removed by distillation leaving a residue of crude base weighing about 7 g.
Solution of the base in cyclohexane results in recovery of 0.8 g. of unreacted starting material. (An additional 1.5
g. of starting material is also recovered from the above ethereal solution after the extraction with hydrochloric acid.) The cyclohexane filtrate is cooled in ice water and 10 ml. of 2.4 N ethereal hydrogen chloride is added resulting in separation of a yellow gum which readily crystallizes. The hygroscopic solid weighs about 5 g.
after drying over P 0 in a vacuum desiccator, and
melts at about 170-175" (d.) with preliminary sintering. It is recrystallized from acetonitrile to a constant melting point of about 175177 (d.) to give about 3.4
g. (44%) based on recovered nucleus.
Analysis.Calcd. for C17H25N30HC1Z N, 10.95; Cl, 12.97. Found: N, 11.11;C1, 12.91.
Similarly, by substituting the following R-substituted- 6,7,8,9-tetrahydro-11H-pyrido[2,1 b]quinazolin-1 l-ones for the 6,7 ,8,9-tetrahydro-1 lH-pyrido[2,1-b1quinazolinll-one in the procedure of step a of Example 1, and following the procedures in the example, the indicated 5-(3 dimerthyl aminopro pyl) R substituted-5,5a,6,7,8,9- hexahydr0-11I-I-pyrido[2,1 bJquinazolin-ll-one hydrochloride is form'ed:
Rcactant (R is) Prod(uct Formed EXAMPLE 14 5- (3-N-melhylpiperazinopropyl) -5,5a,6,7,8,9-hexahydr0- 1 1Hpyrid0[2,1-b]quinazolin-1L0ne hydrochloride Following the the procedure of Example 1, but substituting 3-(N-methylpiperazino)propyl chloride for the 3-dimethylaminopropyl chloride in step b, 5-(3-N-rnethylpiperazinopropyl) 5,5a,6,7,8,9 hexahydro 11H pyrido [2,1-b1quinazolin-1l-one hydrochloride is formed.
Similarly,
but substituting the following B-(lower alkylene)chlorides for the 3-dimethylaminopropyl chloride in the procedure of step b of Example 1, and follow ing the procedure of the example, the indicated 5-amino' alkyl 5,5a,6,7,8,9 hexa'hydno 11H pyrido[2,1 b] quinazolin-l l-one hydrochloride is obtained:
Example Reactant Product 3 T)iethylamin opropyl 2-1\'Ietl1ylaminoethyl Z-Diethylarninoethyl. 2-Benzylamin0ethyl Z-PiperidiuoethyL l-Pyrrolidinobutyl. S-Homopiperidinopropy 2-(3-Piperidinyl)ethyl 3-(N-Phenylpiperazino)- ropyl. 3- N-(Z-HydroxyethyD- piperazino1propyl. 2-Il0mopiperazinoethyL G-Morpholinohexyl 3-Thiam0rpholiuopropy 2- (flgtliylphenethylamino) 3Diethylaminopropy1. 2-Methylaminoethyl.
Z-Diethylaminoethyl.
2-Beuzylaminoethyl. Z-Piperidinoethyl. 4-Iyrrolidinobutyl. 3-HOInopiperidinopr0pyl. 2-(3'Piperidinyl)ethyl. 3-(N-Phenylpiperazino)- ropyl. B-[EN-Q-I-Iydroxyethybpipcrazino1propyl. 2-H0mopiperazinoethyl. tS-Morpholinohexyl. 3-Thiamorpholinopropyl. 2-(Methylphenethylamino) -ethyl. 2-(Dimethylamino) propyl.
EXAMPLE 30 5-(3-dimethylamin0propyl) -5,5a,6,7,8,9hexahydr0- llH-pyrido[2,1-b]quinaz0lin-1l -0ne methochlo ride A solution of 150.0 g. of material from Example 1 in 100 ml. of acetonitrile is cooled and treated with 25 g. of
methyl chloride.
After standing for several days at room temperature, the solution is diluted to 300 ml. with ether to give the methochloride.
The invention may be otherwise embodied within the scope of the appended claims.
What is claimed is: 1. A compound selected from the group consisting of bases of the formula N CH:
(lower alkylene)-B and the pharmaceutically acceptable acid-addition and quaternary ammonium salts thereof, wherein R is selected from the group consisting of hydrogen, lower alkyl, halo- 5 gen. halomethyl, lower alkoxy, mononuclear aryloxy,
amino and di( lower alkyl)amino; and B is a basic nitrogencontaining radical selected from the group consisting of amino, (lower alkyl)amino, di(lwer alkyl)amino, hydroxy(lower alkyl)amino, halo(lower alkyl)amino, di[hydroxy(lower alkyl)]amino, (lower alkyl)phenyl(lower alkyl)amino, piperidyl, (lower alkyl)piperidyl, cli(lower alkyl)piperidyl, homopiperidyl, pyrrolidyl, (lower alkyl) pyrrolidyl, di(lower alkyl)pyrrolidyl, piperazinyl, homopiperazinyl, (lower alkyl)piperazinyl, di(lower alkyl) piperazinyl, (lower alkoxy)piperazinyl, R-phenylpiperazinyl, R-phenyl(lower alkyl)piperazinyl, pyridylpiperazinyl, pyridyl(lower alkyl)piperazinyl, (lower alkanoyloXy-lower alkyl)piperazinyl, (hydroxy-lower alkyl)piperazinyl, morpholinyl, (lower alky1)rnorpholinyl, di(lower alkyl)morpholinyl, thiamorpholinyl, (lower alkyl)thiamorpholinyl and di(lower alkyl)thiamorpholinyl.
2. 5-[di(lower alkyl)amino(lower alkyl)]-5,5 a,6,7,8,9- hexahydro-l lH-pyrido[2,1-b]quinazoli11-1 l-one.
3. A pharmaceutically acceptable salt of the compound of claim 2.
4. 5 (3 dimethylamlnopropyl) 5,5ia,6,7,8,9 hexahydro-11H-pyrido[2,1-b]quinazolin-l l-one.
5. A pharmaceutically acceptable salt of the compound of claim 4.
6. A compound selected from the group consisting of bases of the formula ll 0 5 CH2 CH CH2 NH 0H:
10 and alkali metal derivatives thereof, wherein R is selected from the group consisting of hydrogen, lower alkyl, halogen, halomet-hyl, lower alkoxy, mononuclear aryloxy, amino and di(lower alkyl)amino.
7. 5,5 a,6,7,8,9-hexahydro-11H-pyrido[2,1-b]quinazolin- 15 ll-one.
References Cited by the Examiner UNITED STATES PATENTS 2,621,162 12/1952 Baker 260-2564 2,651,632 9/1953 Baker 260256.4
ALEX MAZEL, Primary Examiner.
HENRY R. JILES, Examiner.
M. U. OBRIEN, Assistant Examiner.
Claims (1)
- 4. 5 - (3 - DIMETHYLAMINOPROPYL) - 5,5A,6,7,8,9 - HEXAHYDRO-11H-PYRIDO(2,1-B) QUINAZOLIN-11 -ONE. 7. 5,5A,6,7,8,9 - HEXAHYDRO - 11H-PYRIDO(2,1-B) QUINAZOLIN-11-ONE.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US390215A US3271396A (en) | 1964-08-17 | 1964-08-17 | Pyrido-quinazoline derivatives |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US390215A US3271396A (en) | 1964-08-17 | 1964-08-17 | Pyrido-quinazoline derivatives |
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| Publication Number | Publication Date |
|---|---|
| US3271396A true US3271396A (en) | 1966-09-06 |
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| Application Number | Title | Priority Date | Filing Date |
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| US390215A Expired - Lifetime US3271396A (en) | 1964-08-17 | 1964-08-17 | Pyrido-quinazoline derivatives |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3484443A (en) * | 1967-11-07 | 1969-12-16 | Jeffrey W H Watthey | Hydroxy-and methoxy hexahydrobenzo(b)quinolizines |
| US3621098A (en) * | 1969-03-17 | 1971-11-16 | Geigy Chem Corp | HYPOTENSIVE METHODS AND COMPOSITIONS UTILIZING HEXAHYDROBENZO{8 b{9 {0 QUINOLIZINES |
| US4220771A (en) * | 1977-08-19 | 1980-09-02 | Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt | 2,3-Polymethylene-4-oxo-4H-pyrido[1,2-a]pyrimidines |
| US4428952A (en) | 1981-06-30 | 1984-01-31 | Farmitalia Carlo Erba S.P.A. | Substituted pyrrolo[2,1-b]quinazolines and pyrido[2,1-b]quinazolines useful for the treatment of or the prevention of gastrointestinal ulcers |
| US4579847A (en) * | 1982-08-05 | 1986-04-01 | Farmitalia Carlo Erba S.P.A. | Amino derivatives of benzylidene-pyrrolo[2,1-b]quinazolines useful for treating conditions of allergic origin |
| US5486512A (en) * | 1991-07-29 | 1996-01-23 | Warner-Lambert Company | Quinazoline derivatives as acetylcholinesterase inhibitors |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2621162A (en) * | 1952-12-09 | J-propargyl-x-quinazolones and acid | ||
| US2651632A (en) * | 1953-09-08 | Acid salts thereof and methods |
-
1964
- 1964-08-17 US US390215A patent/US3271396A/en not_active Expired - Lifetime
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2621162A (en) * | 1952-12-09 | J-propargyl-x-quinazolones and acid | ||
| US2651632A (en) * | 1953-09-08 | Acid salts thereof and methods |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3484443A (en) * | 1967-11-07 | 1969-12-16 | Jeffrey W H Watthey | Hydroxy-and methoxy hexahydrobenzo(b)quinolizines |
| US3621098A (en) * | 1969-03-17 | 1971-11-16 | Geigy Chem Corp | HYPOTENSIVE METHODS AND COMPOSITIONS UTILIZING HEXAHYDROBENZO{8 b{9 {0 QUINOLIZINES |
| US4220771A (en) * | 1977-08-19 | 1980-09-02 | Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt | 2,3-Polymethylene-4-oxo-4H-pyrido[1,2-a]pyrimidines |
| US4428952A (en) | 1981-06-30 | 1984-01-31 | Farmitalia Carlo Erba S.P.A. | Substituted pyrrolo[2,1-b]quinazolines and pyrido[2,1-b]quinazolines useful for the treatment of or the prevention of gastrointestinal ulcers |
| AT381092B (en) * | 1981-06-30 | 1986-08-25 | Erba Farmitalia | METHOD FOR PRODUCING NEW SUBSTITUTED PYRROLO- (2,1-B) -QUINAZOLINES AND PYRIDO (2,1-B) -CHINAZOLINES, THEIR ISOMERS AND THEIR MIXTURES AND THEIR PHARMACEUTICAL SAFE SALTS |
| US4579847A (en) * | 1982-08-05 | 1986-04-01 | Farmitalia Carlo Erba S.P.A. | Amino derivatives of benzylidene-pyrrolo[2,1-b]quinazolines useful for treating conditions of allergic origin |
| US5486512A (en) * | 1991-07-29 | 1996-01-23 | Warner-Lambert Company | Quinazoline derivatives as acetylcholinesterase inhibitors |
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