US3262967A - Process for the preparation of alpha-fluoroacrylates - Google Patents
Process for the preparation of alpha-fluoroacrylates Download PDFInfo
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- US3262967A US3262967A US320518A US32051863A US3262967A US 3262967 A US3262967 A US 3262967A US 320518 A US320518 A US 320518A US 32051863 A US32051863 A US 32051863A US 3262967 A US3262967 A US 3262967A
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- parts
- methyl
- formate
- reaction
- fluoroacrylates
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- 238000000034 method Methods 0.000 title description 13
- 238000002360 preparation method Methods 0.000 title description 4
- TYCFGHUTYSLISP-UHFFFAOYSA-N 2-fluoroprop-2-enoic acid Chemical class OC(=O)C(F)=C TYCFGHUTYSLISP-UHFFFAOYSA-N 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 claims description 3
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 24
- -1 alkali metal alkoxide Chemical class 0.000 description 16
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 14
- 238000006243 chemical reaction Methods 0.000 description 13
- TZIHFWKZFHZASV-UHFFFAOYSA-N methyl formate Chemical compound COC=O TZIHFWKZFHZASV-UHFFFAOYSA-N 0.000 description 8
- 239000000203 mixture Substances 0.000 description 8
- 125000000217 alkyl group Chemical group 0.000 description 7
- 239000002585 base Substances 0.000 description 7
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 7
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 6
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 6
- WQDUMFSSJAZKTM-UHFFFAOYSA-N Sodium methoxide Chemical compound [Na+].[O-]C WQDUMFSSJAZKTM-UHFFFAOYSA-N 0.000 description 6
- 150000002148 esters Chemical class 0.000 description 6
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 6
- 229930040373 Paraformaldehyde Natural products 0.000 description 5
- 229920002866 paraformaldehyde Polymers 0.000 description 5
- 239000000047 product Substances 0.000 description 5
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 4
- QEWYKACRFQMRMB-UHFFFAOYSA-N fluoroacetic acid Chemical compound OC(=O)CF QEWYKACRFQMRMB-UHFFFAOYSA-N 0.000 description 4
- RJBYSQHLLIHSLT-UHFFFAOYSA-N methyl 2-fluoroacetate Chemical compound COC(=O)CF RJBYSQHLLIHSLT-UHFFFAOYSA-N 0.000 description 4
- ZTZJVAOTIOAZGZ-UHFFFAOYSA-N methyl 2-fluoroacrylate Chemical compound COC(=O)C(F)=C ZTZJVAOTIOAZGZ-UHFFFAOYSA-N 0.000 description 4
- KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 description 3
- 229910052783 alkali metal Inorganic materials 0.000 description 3
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 description 3
- 229910000104 sodium hydride Inorganic materials 0.000 description 3
- 239000012312 sodium hydride Substances 0.000 description 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- QIGBRXMKCJKVMJ-UHFFFAOYSA-N Hydroquinone Chemical compound OC1=CC=C(O)C=C1 QIGBRXMKCJKVMJ-UHFFFAOYSA-N 0.000 description 2
- OFBQJSOFQDEBGM-UHFFFAOYSA-N Pentane Chemical compound CCCCC OFBQJSOFQDEBGM-UHFFFAOYSA-N 0.000 description 2
- XBDQKXXYIPTUBI-UHFFFAOYSA-M Propionate Chemical compound CCC([O-])=O XBDQKXXYIPTUBI-UHFFFAOYSA-M 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 238000009835 boiling Methods 0.000 description 2
- NMJJFJNHVMGPGM-UHFFFAOYSA-N butyl formate Chemical compound CCCCOC=O NMJJFJNHVMGPGM-UHFFFAOYSA-N 0.000 description 2
- WBJINCZRORDGAQ-UHFFFAOYSA-N formic acid ethyl ester Natural products CCOC=O WBJINCZRORDGAQ-UHFFFAOYSA-N 0.000 description 2
- 238000006386 neutralization reaction Methods 0.000 description 2
- 239000000376 reactant Substances 0.000 description 2
- 239000011541 reaction mixture Substances 0.000 description 2
- 229920006395 saturated elastomer Polymers 0.000 description 2
- QDRKDTQENPPHOJ-UHFFFAOYSA-N sodium ethoxide Chemical compound [Na+].CC[O-] QDRKDTQENPPHOJ-UHFFFAOYSA-N 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- FERIUCNNQQJTOY-UHFFFAOYSA-M Butyrate Chemical compound CCCC([O-])=O FERIUCNNQQJTOY-UHFFFAOYSA-M 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- XZMCDFZZKTWFGF-UHFFFAOYSA-N Cyanamide Chemical compound NC#N XZMCDFZZKTWFGF-UHFFFAOYSA-N 0.000 description 1
- LCGLNKUTAGEVQW-UHFFFAOYSA-N Dimethyl ether Chemical group COC LCGLNKUTAGEVQW-UHFFFAOYSA-N 0.000 description 1
- BDAGIHXWWSANSR-UHFFFAOYSA-M Formate Chemical compound [O-]C=O BDAGIHXWWSANSR-UHFFFAOYSA-M 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 229910000102 alkali metal hydride Inorganic materials 0.000 description 1
- 150000008046 alkali metal hydrides Chemical class 0.000 description 1
- 150000001340 alkali metals Chemical class 0.000 description 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 229940061607 dibasic sodium phosphate Drugs 0.000 description 1
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N dimethyl sulfoxide Natural products CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 1
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 1
- 238000004821 distillation Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- VCYZVXRKYPKDQB-UHFFFAOYSA-N ethyl 2-fluoroacetate Chemical group CCOC(=O)CF VCYZVXRKYPKDQB-UHFFFAOYSA-N 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 239000012442 inert solvent Substances 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 239000012044 organic layer Substances 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 239000003208 petroleum Substances 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910000105 potassium hydride Inorganic materials 0.000 description 1
- NTTOTNSKUYCDAV-UHFFFAOYSA-N potassium hydride Chemical compound [KH] NTTOTNSKUYCDAV-UHFFFAOYSA-N 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- RCOSUMRTSQULBK-UHFFFAOYSA-N sodium;propan-1-olate Chemical compound [Na+].CCC[O-] RCOSUMRTSQULBK-UHFFFAOYSA-N 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- HXJUTPCZVOIRIF-UHFFFAOYSA-N sulfolane Chemical compound O=S1(=O)CCCC1 HXJUTPCZVOIRIF-UHFFFAOYSA-N 0.000 description 1
- UGNWTBMOAKPKBL-UHFFFAOYSA-N tetrachloro-1,4-benzoquinone Chemical compound ClC1=C(Cl)C(=O)C(Cl)=C(Cl)C1=O UGNWTBMOAKPKBL-UHFFFAOYSA-N 0.000 description 1
- 239000012808 vapor phase Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 238000010626 work up procedure Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/62—Halogen-containing esters
- C07C69/65—Halogen-containing esters of unsaturated acids
Definitions
- esters of tat-fluoroacrylic acid of the structure
- R is a lower alkyl radical, such as methyl, ethyl, Q
- alkyl formates herein employed are: methyl formate, ethyl formate, propyl formate and butyl formate.
- the lower alkyl fiuoroacetates contemplated are: the methyl-, ethyl-, propyl-, butyl-, pentyl-, hexyland heptyl-fluoroacetates, as well as their isomers.
- the formaldehyde reactant can be utilized in any convenient form.
- monomeric formaldehyde conveniently obtained from one of its polymers, paraformaldehyle, by heating the latter and collecting the resultant formaldehyde vapor, can be directly introduced into the reaction product resulting from the initial addition of the formate to the fluoroacetate in the presence of a strong base.
- polymeric formaldehyde can be directly employed during reaction without initially generating formaldehyde vapor.
- Illustrative strong bases that can be employed for the process of the invention are, for example, sodium hydride, potassium hydride, sodium methoxide, sodium ethoxide and sodium propoxide. It is convenient to incorporate an inert solvent such as tetrahydrofuran, ether, benzene, petroleum ether, dimethyl sulfoxide, tetramethylene sulfone and equivalents thereof.
- an inert solvent such as tetrahydrofuran, ether, benzene, petroleum ether, dimethyl sulfoxide, tetramethylene sulfone and equivalents thereof.
- reaction time from at least one hour to about forty-eight hours is sufiicient to effect completion of the over-all reaction.
- the reaction mass is neutralized in any suitable manner and next worked up with an inert organic solvent, such as methyl- 'ene chloride, pentane or benzene, to extract the so-neutralized product which product is next distilled to separate the solvent from the desired a-fluoroacrylate.
- an inert organic solvent such as methyl- 'ene chloride, pentane or benzene
- the temperature employed in the process of the invention is about C., or below. Temperatures between about zero and 75 C. are best for optimum recovery of the desired product.
- Example 1 In a dry atmosphere, a solution of 45.0 parts of methyl fluoroacetate in 88.4 parts of methyl formate is added dropwise during six and one-half hours to a mixture of 39.7 parts of sodium methoxide and 200 parts of tetrahydrofu-ran stirred in an ice bath. During addition, the temperature does-not exceed 4 C. After the addition is completed, the mixture is stirred at room temperature for sixteen hours.
- the mixture is cooled to ice bath temperature and 29.4 parts of paraformaldehyde are added. An immediate temperature rise to 8 C. occurs, but within ten minutes, the temperature returns to 0 C.
- the cold reaction mixture is slowly poured into 325 parts of methylene chloride stirred with a solution of 25.6 parts of hydrochloric acid in parts of water, the mixture being maintained below 20 C. during the neutralization.
- the organic layer is. separated and washed with two portions of saturated aqueous dibasic sodium phosphate and one portion of saturated aqueous sodium chloride. Small amounts of hydroquinone and chloranil are added as inhibitors and the solution is dried at minus 20 C. over anhydrous magnesium sulfate.
- the methylene chloride and most of the tetrahydrofuran are removed by distillation, first at atmospheric pressure and then at reduced pressure.
- the product is distilled at 150 mm. Hg pressure to yield 25.2 parts of distillate having a boiling point of 229 C. to 48.0 C. at 150 mm. Hg.
- the conversion of methyl fluoroace'tate is 44.4 parts, or 99%, and the yield of methyl a-fluoroacrylate based on this conversion is 38%.
- Example 2 The procedure of Example 1 is followed, except that only 15 parts of formaldehyde (as paraformaldehyde) sisting of: 15.9 parts of methyl a-fluoroacrylate, 7.0 parts of methyl fluoroacetate and 3.8 parts of tetrahydrofuran.
- the conversion of methyl fluoroacetate is 38.0 parts, or 84%, and the yield of methyl u-fiuoroacrylate based on this conversion is 37%.
- Example 3 In an anhydrous atmosphere, 45.0 parts of methyl fiuoroacetate are added dropwise over two and threequarter hours to a mixture of 11.8 parts of sodium hydride, 59.0 parts of methyl formate and 144 parts of tetrahydrofuran stir-red in an ice bath. During addition, the temperature never exceeds 4 C. After addition is completed, the mixture is stirred at ice bath temperature for two and one-half hours and then at room temperature for an additional twelve hours.
- the product is distilled at 200 mm. Hg to yield 25.2 parts of distillate possessing a boiling point of 33.5 C. to 57.1 C./200 mm. Hg and consisting of: 19.6 parts of methyl a-fluoroacrylate, 1.7 parts of methyl fluoroacetate and 3.9 parts of tetrahydrofuran.
- the conversion of methyl fiuoroacetate is 43.3 parts or 96%, and the yield of methyl a-fluoroacrylate based on this conversion is 40%.
- R is defined as above, and an aldehyde selected from the group consisting of monomeric formaldehyde and paraformaldehyde, at a temperature between about zero degrees and C. in the presence of a strong base selected from the group consisting of alkali metal alkoxides and alkali metal hydrides, the improvement which comprises: admixing at least an equimolar amount of a lower alkyl formate with said fluoroacetic acid ester, reacting the latter mixture with said aldehyde, and thereafter recovering desired a-fluoroacrylate in good yield and purity.
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Description
United States Patent 3,262,967 PROCESS FOR THE PREPARATION OF a-FLUOROACRYLATES John Andrew Sedlak and Ken Matsuda, Stamford, Conn., assignors to American Cyanamid Company, Stamford, COIIIL, a corporation of Maine No Drawing. Filed Oct. 31, 1963, Ser. No. 320,518
5 Claims. (Cl. 260-486) a This invention relates to the preparation of oc-fllJOl'0- acrylates. More particularly, the invention relates to the preparation of esters of a-fluoroacrylic acid in good yield and purity directly obtained from fluoroacetates.
In the past, it has been difficult, if not impractical, to obtain esters of a-fiuoroacrylic acid from lower alkyl fluoroacetates in good yield and purity. One successful method for preparing a-fluoroacrylates is disclosed and claimed in US. Letters Patent No. 3,075,002 to J. A. Sedlak, issued on January 22, 1963. This patent discloses a process for preparing a-fiuoroacrylates by reacting a lower alkyl fiuoroacetate in the presence of a strong base, such as an alkali metal alkoxide, followed by reaction with an aldehyde, such as formaldehyde or paraformaldehyde. Unfortunately, the yield obtained, although good in view of the direct nature of the process, is not satisfactory for commercial exploitation. If a process could be found in which a-fiuoroacrylates are obtained in good yield and purity that finds acceptance commercially, such a process would be highly desirable.
It is, therefore, a principal object of the present invention to prepare certain unsubstituted a-fluoroacrylates in good yield and purity. Other objects and advantages will be readily ascertained from a consideration of the following detailed description.
It has been found unexpectedly that esters of tat-fluoroacrylic acid of the structure:
CHFCFCOOR wherein R is a lower alkyl radical, such as methyl, ethyl, Q
propyl, butyl or h'exyl, can be obtained in a straightfor= MeOR or HOOOR+ CHzFCOOR T-) i e alkyl alkyl formyl fluoroacetate formate fiuoroacetate ester [11000111 00012] (CII20)x GHFOFCOOR alkyl a-fluoroacrylate wherein Me is an alkali metal, such as sodium or potassium, R is lower alkyl, and x is unity or higher. Although equimolar proportions are indicated in the overall reaction, a mol excess of each of the reactants can be employed without adversely affecting the yield.
In general, the alkyl formates herein employed are: methyl formate, ethyl formate, propyl formate and butyl formate. The lower alkyl fiuoroacetates contemplated are: the methyl-, ethyl-, propyl-, butyl-, pentyl-, hexyland heptyl-fluoroacetates, as well as their isomers.
The formaldehyde reactant can be utilized in any convenient form. Thus, monomeric formaldehyde conveniently obtained from one of its polymers, paraformaldehyle, by heating the latter and collecting the resultant formaldehyde vapor, can be directly introduced into the reaction product resulting from the initial addition of the formate to the fluoroacetate in the presence of a strong base. Alternatively, polymeric formaldehyde can be directly employed during reaction without initially generating formaldehyde vapor.
Illustrative strong bases that can be employed for the process of the invention are, for example, sodium hydride, potassium hydride, sodium methoxide, sodium ethoxide and sodium propoxide. It is convenient to incorporate an inert solvent such as tetrahydrofuran, ether, benzene, petroleum ether, dimethyl sulfoxide, tetramethylene sulfone and equivalents thereof.
It is found that a reaction time from at least one hour to about forty-eight hours is sufiicient to effect completion of the over-all reaction. At the end of this time, the reaction mass is neutralized in any suitable manner and next worked up with an inert organic solvent, such as methyl- 'ene chloride, pentane or benzene, to extract the so-neutralized product which product is next distilled to separate the solvent from the desired a-fluoroacrylate. Prior to work-up, however, the temperature employed in the process of the invention is about C., or below. Temperatures between about zero and 75 C. are best for optimum recovery of the desired product.
To facilitate a further understanding of the invention, the following examples are presented primarily for purposes of illustrating certain more specific details of the invention. Except as defined in the claims, the scope of the disclosure herein is not to be taken as limitative. Parts given are by weight, unless otherwise noted.
Example 1 In a dry atmosphere, a solution of 45.0 parts of methyl fluoroacetate in 88.4 parts of methyl formate is added dropwise during six and one-half hours to a mixture of 39.7 parts of sodium methoxide and 200 parts of tetrahydrofu-ran stirred in an ice bath. During addition, the temperature does-not exceed 4 C. After the addition is completed, the mixture is stirred at room temperature for sixteen hours.
The mixture is cooled to ice bath temperature and 29.4 parts of paraformaldehyde are added. An immediate temperature rise to 8 C. occurs, but within ten minutes, the temperature returns to 0 C. After stirring for two hours in the ice bath, the cold reaction mixture is slowly poured into 325 parts of methylene chloride stirred with a solution of 25.6 parts of hydrochloric acid in parts of water, the mixture being maintained below 20 C. during the neutralization. The organic layer is. separated and washed with two portions of saturated aqueous dibasic sodium phosphate and one portion of saturated aqueous sodium chloride. Small amounts of hydroquinone and chloranil are added as inhibitors and the solution is dried at minus 20 C. over anhydrous magnesium sulfate.
The methylene chloride and most of the tetrahydrofuran are removed by distillation, first at atmospheric pressure and then at reduced pressure. The product is distilled at 150 mm. Hg pressure to yield 25.2 parts of distillate having a boiling point of 229 C. to 48.0 C. at 150 mm. Hg. Vapor phase chromatographic analysis shows that the distillate consists of: 19.1 parts of CH =CFCOOCH 0.6 part of CH FCOOCH and 5.5 parts of tetrahydrofuran. The conversion of methyl fluoroace'tate is 44.4 parts, or 99%, and the yield of methyl a-fluoroacrylate based on this conversion is 38%.
Example 2 The procedure of Example 1 is followed, except that only 15 parts of formaldehyde (as paraformaldehyde) sisting of: 15.9 parts of methyl a-fluoroacrylate, 7.0 parts of methyl fluoroacetate and 3.8 parts of tetrahydrofuran. The conversion of methyl fluoroacetate is 38.0 parts, or 84%, and the yield of methyl u-fiuoroacrylate based on this conversion is 37%.
Example 3 In an anhydrous atmosphere, 45.0 parts of methyl fiuoroacetate are added dropwise over two and threequarter hours to a mixture of 11.8 parts of sodium hydride, 59.0 parts of methyl formate and 144 parts of tetrahydrofuran stir-red in an ice bath. During addition, the temperature never exceeds 4 C. After addition is completed, the mixture is stirred at ice bath temperature for two and one-half hours and then at room temperature for an additional twelve hours.
The mixture is cooled to ice bath temperature and 14.7 parts of paraformaldehyde are added. After stirring for two hours in the ice bath, the reaction mixture is worked up as in Example 1, except that only 18 parts of hydrochloric acid are employed in the neutralization.
The product is distilled at 200 mm. Hg to yield 25.2 parts of distillate possessing a boiling point of 33.5 C. to 57.1 C./200 mm. Hg and consisting of: 19.6 parts of methyl a-fluoroacrylate, 1.7 parts of methyl fluoroacetate and 3.9 parts of tetrahydrofuran. The conversion of methyl fiuoroacetate is 43.3 parts or 96%, and the yield of methyl a-fluoroacrylate based on this conversion is 40%.
We claim: I
1. In an improved process for preparing unsubstituted a-fiuoroacrylic acid esters having the structure:
CHFCFCOOR wherein R is a lower alkyl radical, prepared from the reaction between equimolar amounts of an ester of fluoroacetic acid having the structure:
CH FCOOR wherein R is defined as above, and an aldehyde selected from the group consisting of monomeric formaldehyde and paraformaldehyde, at a temperature between about zero degrees and C. in the presence of a strong base selected from the group consisting of alkali metal alkoxides and alkali metal hydrides, the improvement which comprises: admixing at least an equimolar amount of a lower alkyl formate with said fluoroacetic acid ester, reacting the latter mixture with said aldehyde, and thereafter recovering desired a-fluoroacrylate in good yield and purity.
2. A process according to claim 1, in which the reaction is carried out at a temperature of about 0 C.
3. A process according to claim 1, in which the base is sodium hydride.
4. A process according to claim 1, in which the lower alkyl formate is methyl formate, the fiuoroacetate is methyl fiuoroacetate and the base is sodium methoxide.
5. A process according to claim 1, in which the lower alkyl formate is ethyl formate, the fiuoroacetate is ethyl fluoroacetate, and the base is sodium ethoxide.
References Cited by the Examiner UNITED STATES PATENTS 12/1961 Koch 260486 1/1963 Sedlak 260486
Claims (1)
1. IN AN IMPROVED PROCESS FOR PREPARING UNSUBSTITUTED A-FLUOROACRYLIC ACID ESTERS HAVING THE STRUCTURE:
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US320518A US3262967A (en) | 1963-10-31 | 1963-10-31 | Process for the preparation of alpha-fluoroacrylates |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US320518A US3262967A (en) | 1963-10-31 | 1963-10-31 | Process for the preparation of alpha-fluoroacrylates |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| US3262967A true US3262967A (en) | 1966-07-26 |
Family
ID=33309378
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| US320518A Expired - Lifetime US3262967A (en) | 1963-10-31 | 1963-10-31 | Process for the preparation of alpha-fluoroacrylates |
Country Status (1)
| Country | Link |
|---|---|
| US (1) | US3262967A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014001365A1 (en) | 2012-06-25 | 2014-01-03 | Dsm Ip Assets B.V. | Process for the manufacture of alkylfluoroacrylate |
| WO2025132814A1 (en) | 2023-12-21 | 2025-06-26 | Vifor (International) Ag | Novel synthesis of methyl-2-fluoroacrylate |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3014958A (en) * | 1960-01-15 | 1961-12-26 | Du Pont | Preparation of unsaturated esters |
| US3075002A (en) * | 1962-02-21 | 1963-01-22 | American Cyanamid Co | Process for preparing alpha-fluoroacrylates |
-
1963
- 1963-10-31 US US320518A patent/US3262967A/en not_active Expired - Lifetime
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3014958A (en) * | 1960-01-15 | 1961-12-26 | Du Pont | Preparation of unsaturated esters |
| US3075002A (en) * | 1962-02-21 | 1963-01-22 | American Cyanamid Co | Process for preparing alpha-fluoroacrylates |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014001365A1 (en) | 2012-06-25 | 2014-01-03 | Dsm Ip Assets B.V. | Process for the manufacture of alkylfluoroacrylate |
| CN104520264A (en) * | 2012-06-25 | 2015-04-15 | Dpx精细化学奥地利两合公司 | Process for preparing alkyl fluoroacrylates |
| US20150368178A1 (en) * | 2012-06-25 | 2015-12-24 | Dpx Fine Chemicals Austria Gmbh & Co Kg | Process for the manufacture of alkylfluoroacrylate |
| CN109456187A (en) * | 2012-06-25 | 2019-03-12 | Dpx精细化学奥地利两合公司 | The method for preparing fluoropropenes acid alkyl ester |
| US11420927B2 (en) | 2012-06-25 | 2022-08-23 | Patheon Austria Gmbh & Co Kg | Process for the manufacture of alkylfluoroacrylate |
| CN109456187B (en) * | 2012-06-25 | 2022-08-30 | Dpx精细化学奥地利两合公司 | Process for preparing alkyl fluoroacrylates |
| US11492323B2 (en) | 2012-06-25 | 2022-11-08 | Patheon Austria Gmbh & Co Kg | Process for the manufacture of alkylfluoroacrylate |
| WO2025132814A1 (en) | 2023-12-21 | 2025-06-26 | Vifor (International) Ag | Novel synthesis of methyl-2-fluoroacrylate |
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