US2798816A - Permanently sterilized dental material - Google Patents
Permanently sterilized dental material Download PDFInfo
- Publication number
- US2798816A US2798816A US384509A US38450953A US2798816A US 2798816 A US2798816 A US 2798816A US 384509 A US384509 A US 384509A US 38450953 A US38450953 A US 38450953A US 2798816 A US2798816 A US 2798816A
- Authority
- US
- United States
- Prior art keywords
- copper
- permanently
- cement
- acid
- dental material
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000005548 dental material Substances 0.000 title description 8
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical class [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims description 8
- 150000003891 oxalate salts Chemical class 0.000 claims description 8
- 239000000463 material Substances 0.000 claims description 6
- 230000000844 anti-bacterial effect Effects 0.000 claims description 5
- 239000003479 dental cement Substances 0.000 claims description 3
- 239000002253 acid Substances 0.000 description 11
- 239000004568 cement Substances 0.000 description 10
- 241000894006 Bacteria Species 0.000 description 7
- 229910052802 copper Inorganic materials 0.000 description 7
- 239000010949 copper Substances 0.000 description 7
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 description 6
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 6
- 210000000214 mouth Anatomy 0.000 description 6
- 150000003839 salts Chemical class 0.000 description 6
- 239000000126 substance Substances 0.000 description 6
- 230000002401 inhibitory effect Effects 0.000 description 5
- 239000000843 powder Substances 0.000 description 5
- 150000001879 copper Chemical class 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- LRXTYHSAJDENHV-UHFFFAOYSA-H zinc phosphate Chemical compound [Zn+2].[Zn+2].[Zn+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O LRXTYHSAJDENHV-UHFFFAOYSA-H 0.000 description 4
- 239000002672 zinc phosphate cement Substances 0.000 description 4
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 3
- 230000001066 destructive effect Effects 0.000 description 3
- 239000004033 plastic Substances 0.000 description 3
- 229920003023 plastic Polymers 0.000 description 3
- 230000001580 bacterial effect Effects 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- GPRLSGONYQIRFK-UHFFFAOYSA-N hydron Chemical compound [H+] GPRLSGONYQIRFK-UHFFFAOYSA-N 0.000 description 2
- HMUNWXXNJPVALC-UHFFFAOYSA-N 1-[4-[2-(2,3-dihydro-1H-inden-2-ylamino)pyrimidin-5-yl]piperazin-1-yl]-2-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)ethanone Chemical compound C1C(CC2=CC=CC=C12)NC1=NC=C(C=N1)N1CCN(CC1)C(CN1CC2=C(CC1)NN=N2)=O HMUNWXXNJPVALC-UHFFFAOYSA-N 0.000 description 1
- VZSRBBMJRBPUNF-UHFFFAOYSA-N 2-(2,3-dihydro-1H-inden-2-ylamino)-N-[3-oxo-3-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)propyl]pyrimidine-5-carboxamide Chemical compound C1C(CC2=CC=CC=C12)NC1=NC=C(C=N1)C(=O)NCCC(N1CC2=C(CC1)NN=N2)=O VZSRBBMJRBPUNF-UHFFFAOYSA-N 0.000 description 1
- WZFUQSJFWNHZHM-UHFFFAOYSA-N 2-[4-[2-(2,3-dihydro-1H-inden-2-ylamino)pyrimidin-5-yl]piperazin-1-yl]-1-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)ethanone Chemical compound C1C(CC2=CC=CC=C12)NC1=NC=C(C=N1)N1CCN(CC1)CC(=O)N1CC2=C(CC1)NN=N2 WZFUQSJFWNHZHM-UHFFFAOYSA-N 0.000 description 1
- JPVYNHNXODAKFH-UHFFFAOYSA-N Cu2+ Chemical compound [Cu+2] JPVYNHNXODAKFH-UHFFFAOYSA-N 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- DOVLHZIEMGDZIW-UHFFFAOYSA-N [Cu+3].[O-]B([O-])[O-] Chemical compound [Cu+3].[O-]B([O-])[O-] DOVLHZIEMGDZIW-UHFFFAOYSA-N 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 229910001431 copper ion Inorganic materials 0.000 description 1
- ZZBBCSFCMKWYQR-UHFFFAOYSA-N copper;dioxido(oxo)silane Chemical compound [Cu+2].[O-][Si]([O-])=O ZZBBCSFCMKWYQR-UHFFFAOYSA-N 0.000 description 1
- QYCVHILLJSYYBD-UHFFFAOYSA-L copper;oxalate Chemical compound [Cu+2].[O-]C(=O)C([O-])=O QYCVHILLJSYYBD-UHFFFAOYSA-L 0.000 description 1
- 208000002925 dental caries Diseases 0.000 description 1
- 239000000645 desinfectant Substances 0.000 description 1
- 230000000249 desinfective effect Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 235000021395 porridge Nutrition 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- 238000007711 solidification Methods 0.000 description 1
- 230000008023 solidification Effects 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 239000003206 sterilizing agent Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/60—Preparations for dentistry comprising organic or organo-metallic additives
- A61K6/69—Medicaments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
- A61K6/849—Preparations for artificial teeth, for filling teeth or for capping teeth comprising inorganic cements
- A61K6/864—Phosphate cements
Definitions
- the present invention relates to dental materials which are rendered permanently sterile by the inclusion of a disinfecting agent which inhibits the growth of acid forming bacteria in the oral cavity.
- dental materials include cements and other materials such as those having a plastic base.
- the most satisfactory for dental use are salts of copper.
- Cuprioxide because of its dark brown color, is unsuited for use in the oral cavity, except in the molar region.
- Cuproiodide is insufiiciently soluble for effective prevention of bacterial growth. It inhibits the growth of certain bacteria, but not the action of their enzymes which catalyze the formation of destructive acids.
- the salt of a strong acid cuproiodide shows only a negligible increase in solubility in slightly acid solutions, thus impairing its elfeetiveness as an inhibiting agent.
- a further object of the invention is the provision of an acid-sensitive dental material of this character in which copper ions are released in the presence of relatively low hydrogen ion concentrations in order that the inhibiting action of the sterilizing agent may become effective as soon as the destructive action of the acid forming bacteria commences.
- Still another object of the invention is the provision of a copper salt as an inhibiting agent, the copper salt being of such character as to resist complete solution when mixed to form a cement using a cement liquid containing phosphoric acid.
- oxalates and basic oxalates of copper are used to inhibit the growth of acid forming bacteria.
- These oxalates are the salts of an acid which is only moderately strong. They exhibit increasing solubility with increasing hydrogen ion concentration, but are not entirely dissolved when mixed to form a cement using a cement liquid which contains phosphoric acid.
- a salt of a weak acid such as copper silicate or copper borate
- the copper salt is substantially completely dissolved by the phosphoric acid of the cement liquid, and after solidification of the cement, the copper is present in the form of cupriand cupro-phosphate.
- Cuprioxalate is of a light green-blue color and cuprooxalate is even lighter in color. These salts have no unsightly discoloring effect when included in a dental cement. The use of up to 10% by weight of such salts when added to a cement powder does not produce any ofiensive stain. Moreover, cuprioxalate and cuprooxalate may also be used as additives to non-cementitious dental materials, such as plastics.
- the basic oxalates of copper are suitable for use in the same manner as the normal oxalates.
- Dental materials whether used for filling, adhesive or other purposes may be made inherently permanently inhibitive to the growth of destructive acid forming bacteria by the inclusion in their composition of up to 10% by weight of either a normal oxalate of copper or a basic oxalate thereof. The following examples are given by way of illustra tion.
- Example 1 1 kg. dry zinc phosphate cement powder and 50 g. dry cuprioxalate are ground together in a ball mill until a mixture of homogeneous appearance is obtained. One gram of this mixture is mixed on a glass slab with 0.3 g. of the usual cement liquid using a plastic spatula. The resulting cement porridge is used in the conventional manner for the fixation of crowns, bridges, etc.
- Example 2 1 kg. of dry zinc phosphate cement powder is combined as in Example 1, using 50 g. of dry cuprooxalate instead of cuprioxalate.
- Example 3 1 kg. of dry zinc phosphate cement powder is combined as in Example 1, using 50 g. of dry basic cuprioxalate.
- Example 4 1 kg. of dry zincphosphate cement powder is combined as in Example 1, usingjO g. of dry basic cuprooxalate. Having thus described my invention, what is claimed 1.
- a permanently bactericidal dental cement consisting essentially of a base material and a bactericidal amount up to 10% by weight of a copper salt selected from the group consisting of cuprioxalate, cuprooxalate and the basic oxalates of copper.
- the process for destroying acid-forming bacteria in the oral cavity which comprises applying to the oral cavity a cementitious composition in which a copper oxalate is present in a bactericidal amount up to 10% by weight.
Landscapes
- Health & Medical Sciences (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Plastic & Reconstructive Surgery (AREA)
- Dental Preparations (AREA)
Description
Unites K t PERMANENTLY STERILIZED DENTAL MATERIAL Adolf Knappwost, Neuhausen, near Urach, Germany, assignor to Vivadent Corporation, Boston, Mass, a corporation of Massachusetts No Drawing. Application October 6, 1953, Serial No. 384,509
Claims priority, application Germany October 15, 1952 6 Claims. (Cl. 106-65) The present invention relates to dental materials which are rendered permanently sterile by the inclusion of a disinfecting agent which inhibits the growth of acid forming bacteria in the oral cavity. Such dental materials include cements and other materials such as those having a plastic base.
Among the presently known disinfecting, sterilizing, or prophylactic materials, the most satisfactory for dental use are salts of copper. Cuprioxide, because of its dark brown color, is unsuited for use in the oral cavity, except in the molar region. Cuproiodide is insufiiciently soluble for effective prevention of bacterial growth. It inhibits the growth of certain bacteria, but not the action of their enzymes which catalyze the formation of destructive acids. As the salt of a strong acid, cuproiodide shows only a negligible increase in solubility in slightly acid solutions, thus impairing its elfeetiveness as an inhibiting agent.
Accordingly, it is among the objects of the present invention to produce a permanently sterile dental material sufliciently light in color to permit its use in all portions of the oral cavity.
A further object of the invention is the provision of an acid-sensitive dental material of this character in which copper ions are released in the presence of relatively low hydrogen ion concentrations in order that the inhibiting action of the sterilizing agent may become effective as soon as the destructive action of the acid forming bacteria commences.
Still another object of the invention is the provision of a copper salt as an inhibiting agent, the copper salt being of such character as to resist complete solution when mixed to form a cement using a cement liquid containing phosphoric acid.
Other and further objects will become apparent upon reading the following specification.
In accordance with the present invention, oxalates and basic oxalates of copper are used to inhibit the growth of acid forming bacteria. These oxalates are the salts of an acid which is only moderately strong. They exhibit increasing solubility with increasing hydrogen ion concentration, but are not entirely dissolved when mixed to form a cement using a cement liquid which contains phosphoric acid. In the case of a salt of a weak acid, such as copper silicate or copper borate, the copper salt is substantially completely dissolved by the phosphoric acid of the cement liquid, and after solidification of the cement, the copper is present in the form of cupriand cupro-phosphate.
Cuprioxalate is of a light green-blue color and cuprooxalate is even lighter in color. These salts have no unsightly discoloring effect when included in a dental cement. The use of up to 10% by weight of such salts when added to a cement powder does not produce any ofiensive stain. Moreover, cuprioxalate and cuprooxalate may also be used as additives to non-cementitious dental materials, such as plastics.
REFERENCE:
2,798,816 Patented July 9, 1957 Also taking into consideration, the fact that any material inhibitive of the growth of acid producing bacteria must not only inhibit bacterial growth in the dental structure to which it is applied, but must operate to provide effective prophylaxis of the surrounding tooth structure, in order to avoid the development of dangerous secondary caries. For this reason, the oxalates of copper which form the subject matter of the present invention are particularly valuable when included as a component of any substance intended for use in the oral cavity.
The basic oxalates of copper, whether monoor divalent, are suitable for use in the same manner as the normal oxalates. Dental materials, whether used for filling, adhesive or other purposes may be made inherently permanently inhibitive to the growth of destructive acid forming bacteria by the inclusion in their composition of up to 10% by weight of either a normal oxalate of copper or a basic oxalate thereof. The following examples are given by way of illustra tion.
Example 1 1 kg. dry zinc phosphate cement powder and 50 g. dry cuprioxalate are ground together in a ball mill until a mixture of homogeneous appearance is obtained. One gram of this mixture is mixed on a glass slab with 0.3 g. of the usual cement liquid using a plastic spatula. The resulting cement porridge is used in the conventional manner for the fixation of crowns, bridges, etc.
Example 2 1 kg. of dry zinc phosphate cement powder is combined as in Example 1, using 50 g. of dry cuprooxalate instead of cuprioxalate.
Example 3 1 kg. of dry zinc phosphate cement powder is combined as in Example 1, using 50 g. of dry basic cuprioxalate.
Example 4 1 kg. of dry zincphosphate cement powder is combined as in Example 1, usingjO g. of dry basic cuprooxalate. Having thus described my invention, what is claimed 1. A permanently bactericidal dental cement consisting essentially ofa base material and a bactericidal amount up to 10% by weight of a copper salt selected from the group consisting of cuprioxalate, cuprooxalate and the basic oxalates of copper.
2. A substance as in claim 1, wherein said oxalate is basic cuprioxalate.
3. A substance as in claim 1, normal cuprioxalate.
4. A substance as in claim 1, basic cuprooxalate.
5. A substance as in claim 1, normal cuprooxalate.
6. The process for destroying acid-forming bacteria in the oral cavity, which comprises applying to the oral cavity a cementitious composition in which a copper oxalate is present in a bactericidal amount up to 10% by weight.
wherein said oxalate is wherein said oxalate is wherein said oxalate is References Cited in the file of this patent UNITED STATES PATENTS 1,226,232 Mahan May 15, 1917 1,886,982 Simon Nov. 8, 1932 FOREIGN PATENTS 134,156 Australia Sept. 6, 1947 OTHER REFERENCES Gregory: Uses and Applications of Chemicals and Related Materials, vol. II (1944), page 87.
Claims (1)
1.A PERMANENTLY BACTERICIDAL DENTAL CEMENT CONSISTING ESSENTIALLY OF A BASE MATERIAL AND A BACTERICIDAL AMOUNT UP TO 10% BY WEIGHT OF A COPPER SALT SELECTED FROM THE GROUP CONSISTING OF CUPRIOXALATE, CUPROOXALATE AND THE BASSIC OXALATES OF COPPER.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2798816X | 1952-10-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| US2798816A true US2798816A (en) | 1957-07-09 |
Family
ID=7998598
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| US384509A Expired - Lifetime US2798816A (en) | 1952-10-15 | 1953-10-06 | Permanently sterilized dental material |
Country Status (1)
| Country | Link |
|---|---|
| US (1) | US2798816A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1088665B (en) * | 1958-02-24 | 1960-09-08 | Spofa Sdruzeni Podnikuu Pro Zd | Copper or silicate cement powder for the production of dental cements |
| US3246998A (en) * | 1962-11-02 | 1966-04-19 | Higashi Setsuo | Impression material |
| US3476577A (en) * | 1967-03-22 | 1969-11-04 | United States Steel Corp | Antifoulant composition and method |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1226232A (en) * | 1916-06-13 | 1917-05-15 | Lee S Smith And Son Mfg Company | Dental cement. |
| US1886982A (en) * | 1928-05-26 | 1932-11-08 | Simon Otto | Process of producing cements for teeth |
-
1953
- 1953-10-06 US US384509A patent/US2798816A/en not_active Expired - Lifetime
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1226232A (en) * | 1916-06-13 | 1917-05-15 | Lee S Smith And Son Mfg Company | Dental cement. |
| US1886982A (en) * | 1928-05-26 | 1932-11-08 | Simon Otto | Process of producing cements for teeth |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1088665B (en) * | 1958-02-24 | 1960-09-08 | Spofa Sdruzeni Podnikuu Pro Zd | Copper or silicate cement powder for the production of dental cements |
| US3246998A (en) * | 1962-11-02 | 1966-04-19 | Higashi Setsuo | Impression material |
| US3476577A (en) * | 1967-03-22 | 1969-11-04 | United States Steel Corp | Antifoulant composition and method |
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