US2776924A - Composition of matter containing polyvinylpyrrolidone and a fatty carrier - Google Patents
Composition of matter containing polyvinylpyrrolidone and a fatty carrier Download PDFInfo
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- US2776924A US2776924A US408600A US40860054A US2776924A US 2776924 A US2776924 A US 2776924A US 408600 A US408600 A US 408600A US 40860054 A US40860054 A US 40860054A US 2776924 A US2776924 A US 2776924A
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- Prior art keywords
- fatty
- polyvinylpyrrolidone
- composition
- carrier
- matter
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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- 239000001267 polyvinylpyrrolidone Substances 0.000 title claims description 25
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 title claims description 25
- 229920000036 polyvinylpyrrolidone Polymers 0.000 title claims description 23
- 239000000203 mixture Substances 0.000 title claims description 19
- 150000002191 fatty alcohols Chemical class 0.000 claims description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 9
- 150000001875 compounds Chemical class 0.000 claims description 6
- 239000012456 homogeneous solution Substances 0.000 claims description 5
- 239000002253 acid Substances 0.000 claims description 4
- 150000007513 acids Chemical class 0.000 claims description 4
- 239000013543 active substance Substances 0.000 description 10
- 235000014113 dietary fatty acids Nutrition 0.000 description 8
- 235000019197 fats Nutrition 0.000 description 8
- 239000000194 fatty acid Substances 0.000 description 8
- 229930195729 fatty acid Natural products 0.000 description 8
- 150000004665 fatty acids Chemical class 0.000 description 8
- 210000004400 mucous membrane Anatomy 0.000 description 7
- 210000002615 epidermis Anatomy 0.000 description 6
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 239000011630 iodine Substances 0.000 description 5
- 229910052740 iodine Inorganic materials 0.000 description 5
- 230000000622 irritating effect Effects 0.000 description 5
- 239000000843 powder Substances 0.000 description 5
- 239000000969 carrier Substances 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 4
- 230000002401 inhibitory effect Effects 0.000 description 4
- 229910052500 inorganic mineral Inorganic materials 0.000 description 4
- 239000011707 mineral Substances 0.000 description 4
- 239000002904 solvent Substances 0.000 description 4
- 241001465754 Metazoa Species 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 239000004359 castor oil Substances 0.000 description 3
- 235000019438 castor oil Nutrition 0.000 description 3
- 239000002385 cottonseed oil Substances 0.000 description 3
- 235000012343 cottonseed oil Nutrition 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 3
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 3
- -1 lard Substances 0.000 description 3
- 239000002480 mineral oil Substances 0.000 description 3
- 235000010446 mineral oil Nutrition 0.000 description 3
- 239000003921 oil Substances 0.000 description 3
- 235000019198 oils Nutrition 0.000 description 3
- 210000003491 skin Anatomy 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- 235000013311 vegetables Nutrition 0.000 description 3
- DSEKYWAQQVUQTP-XEWMWGOFSA-N (2r,4r,4as,6as,6as,6br,8ar,12ar,14as,14bs)-2-hydroxy-4,4a,6a,6b,8a,11,11,14a-octamethyl-2,4,5,6,6a,7,8,9,10,12,12a,13,14,14b-tetradecahydro-1h-picen-3-one Chemical compound C([C@H]1[C@]2(C)CC[C@@]34C)C(C)(C)CC[C@]1(C)CC[C@]2(C)[C@H]4CC[C@@]1(C)[C@H]3C[C@@H](O)C(=O)[C@@H]1C DSEKYWAQQVUQTP-XEWMWGOFSA-N 0.000 description 2
- 239000004166 Lanolin Substances 0.000 description 2
- 230000002411 adverse Effects 0.000 description 2
- 235000013871 bee wax Nutrition 0.000 description 2
- 239000012166 beeswax Substances 0.000 description 2
- 235000019868 cocoa butter Nutrition 0.000 description 2
- 229940110456 cocoa butter Drugs 0.000 description 2
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 description 2
- 235000019388 lanolin Nutrition 0.000 description 2
- 229940039717 lanolin Drugs 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000012254 powdered material Substances 0.000 description 2
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 2
- 239000000454 talc Substances 0.000 description 2
- 229910052623 talc Inorganic materials 0.000 description 2
- 229940124597 therapeutic agent Drugs 0.000 description 2
- 239000001993 wax Substances 0.000 description 2
- ALSTYHKOOCGGFT-KTKRTIGZSA-N (9Z)-octadecen-1-ol Chemical compound CCCCCCCC\C=C/CCCCCCCCO ALSTYHKOOCGGFT-KTKRTIGZSA-N 0.000 description 1
- 235000021314 Palmitic acid Nutrition 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 229940124326 anaesthetic agent Drugs 0.000 description 1
- 230000003444 anaesthetic effect Effects 0.000 description 1
- 239000004203 carnauba wax Substances 0.000 description 1
- 235000013869 carnauba wax Nutrition 0.000 description 1
- 125000003438 dodecyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000010514 hydrogenated cottonseed oil Substances 0.000 description 1
- 239000002085 irritant Substances 0.000 description 1
- 231100000021 irritant Toxicity 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 1
- 231100001231 less toxic Toxicity 0.000 description 1
- 210000004379 membrane Anatomy 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 125000001421 myristyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 description 1
- 229940055577 oleyl alcohol Drugs 0.000 description 1
- XMLQWXUVTXCDDL-UHFFFAOYSA-N oleyl alcohol Natural products CCCCCCC=CCCCCCCCCCCO XMLQWXUVTXCDDL-UHFFFAOYSA-N 0.000 description 1
- 239000004006 olive oil Substances 0.000 description 1
- 235000008390 olive oil Nutrition 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229960004889 salicylic acid Drugs 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 150000003330 sebacic acids Chemical class 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 125000004079 stearyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
Definitions
- This invention relates to compositions of matter containing polyvinylpyrrolidone and more specifically, compositions including polyvinylpyrrolidone homogeneously dissolved in a carrier of a fatty or oily nature.
- Polyvinylpyrrolidone (l-vinyl-2-pyrrolidone polymer) is a white powder which is readily soluble in water and certain organic solvents but is normally insoluble in fatty or oily carriers.
- polyvinylpyr-rolidone has a number of important properties, particularly in the therapeutic field, it is im portant that the polyvinylpyrrolidone be made compatible with as many different types of solvents and carriers, as possible.
- polyvinylpyrrolidone may detoxify therapeutic agents which are more or less toxic in charactor and also has the property of prolonging the eifective period of many drugs and anaesthetics.
- one object of this invent-ion is to provide a composition of matter including a carrier of a fatty or oily nature and polyvinylpyrrolidone homogeneously dissolved in said carrier by means of a compound having a common solvent action with respect :0 the base and the polyvinylpyrrolidone.
- Another object of this invention is to provide a composition of matter including a physiologically active agent which normally has an irritating effect when applied to the epidermis or mucous membranes, and polyvinylpyrrolidone for inhibiting the undesirable effects of said agent, all homogeneously distributed in a fatty carrier by means of a common solvent.
- Yet another object of this invention is to provide a composition of matter including a therapeutic or physiologically active agent which may be of a toxic nature and has an irritating effect when applied to the epidermis or the mucous membranes, and polyvinylpyrrolidone for inhibiting the undesirable effects of such agent, all homogeneously distributed in a fatty carrier by means of a fatty acid or fatty alcohol.
- a therapeutic or physiologically active agent which may be of a toxic nature and has an irritating effect when applied to the epidermis or the mucous membranes
- polyvinylpyrrolidone for inhibiting the undesirable effects of such agent, all homogeneously distributed in a fatty carrier by means of a fatty acid or fatty alcohol.
- Still another object of this invention is to provide a composition of matter in powder form applicable to the epidemis or mucous membranes and including an active agent which is normally irritating with respect to the epidermis or mucous membranes, wherein the active agent together with polyvinylpyrrolidone is dissolved in a fat or oil carrier by means of a common solvent, the solution being combined with an inert powdered carrier to form a powdered material free of the undesirable properties of the active agent.
- polyvinylpyrrolidone may be dissolved in fatty or oil carriers and waxes of animal, vegetable or mineral origin, in their normal state or in hydrogenated form, such .as lanolin, lard, mineral oil, cottonseed oil, castor oil, cocoa butter, beeswax, carnauba wax, ozokerite and the like, through the use of fatty acids or fatty alcohols.
- physiologically active agents Whose normally adverse physiological properties may be inhibited by the addition thereto of polyvinylpyrrolidone, such as iodine, salicylic acid or the like, may be uniformly dis- 2,776,924 Patented Jan. 8, 1957 i 2 tributed in a fatty carrier by the use 'of fatty acids or fatty alcohols, for application to the epidermis ormucous membranes and free of undesirable effects relative thereto.
- polyvinylpyrrolidone such as iodine, salicylic acid or the like
- Example 1 E xamp le 2 0.2 gram of iodine in methyl alcohol was combined with 2 grams of polyvinylpyrrol-idon'e and 8 grams of oleyl alcohol and dissolved in 19.8 grams of mineral oil to give a homogeneous solution.
- the mineral .oil may be replaced by a lanolin carrier and the proportion of iodine used may be varied to give any desired concentration in the 'fatty carrier.
- Example 3 2.0 grams :of polyvinylpyrrolidone .was added to 8.0 grams of palmitic acid to form a homogeneous mass. 30.0 grams of castor oil was added to the mass and produced a clear solution. The castor oil can be replaced by cottonseed oil or hydrogenated cottonseed oil.
- Example 4 A solution of iodine and polyvinylpyrrolidone in a mineral oil carrier, as set forth in Example 1, was combined with an inert powdered material such as talc until the solid particles were well saturated with the solution yet provided a freely flowing powder.
- the resultant powder can be readily applied to the human skin for therapeutic purposes without danger of irritation.
- Other inert materials such as china clay, or the like may replace the talc as a carrier for the iatty solution of poly- 'vinylpym'olidone and iodine.
- polyvinylpyrrolidone may also be readily dissolved in various fatty or oily carriers as well as waxes, of animal, vegetable or mineral origin, including cottonseed oil, olive oil, cocoa butter, beeswax, ozokerite or the like, as well as hydrogenated forms thereof, by means of fatty acids or fatty alcohols including lauric, myristic, palmitic, stearic, or sebacic acids and 'lau-ryl, myristyl, stearyl or oleyl alcohols and mixtures of such acids and alcohols.
- fatty acids or fatty alcohols including lauric, myristic, palmitic, stearic, or sebacic acids and 'lau-ryl, myristyl, stearyl or oleyl alcohols and mixtures of such acids and alcohols.
- oily and waxy materials which may be of animal, mineral :or vegetable origin shall be deemed the substantial equivalent of the water insoluble, fat soluble fatty alcohols and acids previously described, for use in the compositions of the instant invention.
- composition of matter consistingessentia'lly of a homogeneous solution of .polyvinylpyrrolidone, a fatty carrier and a compound selected from the group consistingaof water insoluble," fat soluble'ifa'tty acids. and fatty alcoholsz.
- composition of matterconsistings essentially of a homogeneous solution of polyvinylpyrrolidone, a fatty carrier and a water insoluble, fat solu'hle fatty alcohol.
- composition of matter consisting essentially of a physiologically active agent having irritant effects when applied to the epidermis or mucous membranes, polyvinylp'y-r-roli-done for inhibiting saidirritant effects, a'fatty carrier for said agent andinhi bitor, and a compound selected from the group consisting of water insoluble, fat soluble fatty acids and fatty alcohols.
- a composition of matter consisting essentially of a fatty carrier, polyvinylpyrrolidone, iodine, and a compound selected from the groupconsisting of water insoluble, 'fat soluble fatty acids and fatty alcohols.
- a composition of matter in powder form comprising a solution including essentially a fatty ca-r-rier, polyvinylpyrrolidone and a compound selected from the group consisting of water insoluble, fat soluble fatty acids and fatty alcohols, and a powdered, inert inorganic vehicle for said solution.
- composition as in cla'im6 said solution further including a physiologically active agent having irritant effects when applied to the epidermis or mucous membranes, the polyvinylpyrrolidone inhibiting said irritant efiects.
- composition assin claim 7 said physiologically active agent being iodine.
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Inorganic Chemistry (AREA)
- Dermatology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
United States Patent COMPOSITION OF MATTER CONTAINING POLY- VINYLPYRROLIDONE AND A FATTY CARRIER Jean R. L. Martin, New York, N. Y., assignor to Coty, Inc., New York, N. Y., a corporation of Delaware No Drawing. Application February 5, 1954, Serial No. 408,600
8 Claims. (Cl. 167-82) This invention relates to compositions of matter containing polyvinylpyrrolidone and more specifically, compositions including polyvinylpyrrolidone homogeneously dissolved in a carrier of a fatty or oily nature.
Polyvinylpyrrolidone (l-vinyl-2-pyrrolidone polymer) is a white powder which is readily soluble in water and certain organic solvents but is normally insoluble in fatty or oily carriers.
Since polyvinylpyr-rolidone has a number of important properties, particularly in the therapeutic field, it is im portant that the polyvinylpyrrolidone be made compatible with as many different types of solvents and carriers, as possible. Thus, polyvinylpyrrolidone may detoxify therapeutic agents which are more or less toxic in charactor and also has the property of prolonging the eifective period of many drugs and anaesthetics.
Accordingly, one object of this invent-ion is to provide a composition of matter including a carrier of a fatty or oily nature and polyvinylpyrrolidone homogeneously dissolved in said carrier by means of a compound having a common solvent action with respect :0 the base and the polyvinylpyrrolidone.
Another object of this invention is to provide a composition of matter including a physiologically active agent which normally has an irritating effect when applied to the epidermis or mucous membranes, and polyvinylpyrrolidone for inhibiting the undesirable effects of said agent, all homogeneously distributed in a fatty carrier by means of a common solvent.
Yet another object of this invention is to provide a composition of matter including a therapeutic or physiologically active agent which may be of a toxic nature and has an irritating effect when applied to the epidermis or the mucous membranes, and polyvinylpyrrolidone for inhibiting the undesirable effects of such agent, all homogeneously distributed in a fatty carrier by means of a fatty acid or fatty alcohol.
Still another object of this invention is to provide a composition of matter in powder form applicable to the epidemis or mucous membranes and including an active agent which is normally irritating with respect to the epidermis or mucous membranes, wherein the active agent together with polyvinylpyrrolidone is dissolved in a fat or oil carrier by means of a common solvent, the solution being combined with an inert powdered carrier to form a powdered material free of the undesirable properties of the active agent.
It has been found that substantial amounts of polyvinylpyrrolidone may be dissolved in fatty or oil carriers and waxes of animal, vegetable or mineral origin, in their normal state or in hydrogenated form, such .as lanolin, lard, mineral oil, cottonseed oil, castor oil, cocoa butter, beeswax, carnauba wax, ozokerite and the like, through the use of fatty acids or fatty alcohols.
Furthermore, physiologically active agents Whose normally adverse physiological properties may be inhibited by the addition thereto of polyvinylpyrrolidone, such as iodine, salicylic acid or the like, may be uniformly dis- 2,776,924 Patented Jan. 8, 1957 i 2 tributed in a fatty carrier by the use 'of fatty acids or fatty alcohols, for application to the epidermis ormucous membranes and free of undesirable effects relative thereto.
The following examples illustrate the present invention but it is understood that such examples do not limit the scope of said invention.
Example 1 E xamp le 2 0.2 gram of iodine in methyl alcohol was combined with 2 grams of polyvinylpyrrol-idon'e and 8 grams of oleyl alcohol and dissolved in 19.8 grams of mineral oil to give a homogeneous solution. The mineral .oil may be replaced by a lanolin carrier and the proportion of iodine used may be varied to give any desired concentration in the 'fatty carrier.
Example 3 2.0 grams :of polyvinylpyrrolidone .was added to 8.0 grams of palmitic acid to form a homogeneous mass. 30.0 grams of castor oil was added to the mass and produced a clear solution. The castor oil can be replaced by cottonseed oil or hydrogenated cottonseed oil.
Example 4 A solution of iodine and polyvinylpyrrolidone in a mineral oil carrier, as set forth in Example 1, was combined with an inert powdered material such as talc until the solid particles were well saturated with the solution yet provided a freely flowing powder. The resultant powder can be readily applied to the human skin for therapeutic purposes without danger of irritation. Other inert materials such as china clay, or the like may replace the talc as a carrier for the iatty solution of poly- 'vinylpym'olidone and iodine.
"It has been found that substantial amounts of polyvinylpyrrolidone may also be readily dissolved in various fatty or oily carriers as well as waxes, of animal, vegetable or mineral origin, including cottonseed oil, olive oil, cocoa butter, beeswax, ozokerite or the like, as well as hydrogenated forms thereof, by means of fatty acids or fatty alcohols including lauric, myristic, palmitic, stearic, or sebacic acids and 'lau-ryl, myristyl, stearyl or oleyl alcohols and mixtures of such acids and alcohols.
It is also understood that various physiologically active agents, therapeutic agents and the like, which may normally have adverse effects when applied to the skin or mucous membranes, may be readily combined with polyvinylpyrrolidone to inhibit such ad-verse eifects, the combination being homogeneously dissolved in a fatty or oily carrier, in accordance with the present invention, thereby facilitating the application of such agents to the skin or other portions of the human body.
It is to be understood that oily and waxy materials, which may be of animal, mineral :or vegetable origin shall be deemed the substantial equivalent of the water insoluble, fat soluble fatty alcohols and acids previously described, for use in the compositions of the instant invention.
The foregoing examples are to be deemed illustrative tion on the scope of the claims following.
Whatis claimedis:
1. A composition of matter consistingessentia'lly of a homogeneous solution of .polyvinylpyrrolidone, a fatty carrier and a compound selected from the group consistingaof water insoluble," fat soluble'ifa'tty acids. and fatty alcoholsz.
ZUA composition of matterzzconsisting essentially of a homogeneous solution of polyvinylpynrolidone, a fatty carrier'andia water insoluble, fat soluble fatty acid.
3. A composition of matterconsistingsessentially of a homogeneous solution of polyvinylpyrrolidone, a fatty carrier and a water insoluble, fat solu'hle fatty alcohol.
4. A composition of matter consisting essentially of a physiologically active agent having irritant effects when applied to the epidermis or mucous membranes, polyvinylp'y-r-roli-done for inhibiting saidirritant effects, a'fatty carrier for said agent andinhi bitor, and a compound selected from the group consisting of water insoluble, fat soluble fatty acids and fatty alcohols.
'5. A composition of matter consisting essentially of a fatty carrier, polyvinylpyrrolidone, iodine, and a compound selected from the groupconsisting of water insoluble, 'fat soluble fatty acids and fatty alcohols.
6. A composition of matter in powder form comprising a solution including essentially a fatty ca-r-rier, polyvinylpyrrolidone and a compound selected from the group consisting of water insoluble, fat soluble fatty acids and fatty alcohols, and a powdered, inert inorganic vehicle for said solution.
7. A composition as in cla'im6, said solution further including a physiologically active agent having irritant effects when applied to the epidermis or mucous membranes, the polyvinylpyrrolidone inhibiting said irritant efiects.
S. A composition assin claim 7, said physiologically active agent being iodine.
References Cited in the file of this patent UNITED STATES PATENTS Esselen Dec. 3, 1935 OTHER REFERENCES
Claims (1)
1. A COMPOSITION OF MATTER CONSISTING ESSENTIALLY OF A HOMOGENEOUS SOLUTION OF POLYVINYLPYRROLIDONE, A FATTY CARRIER AND A COMPOUND SELECTED FROM THE GROUP CONSISTING OF WATER INSOLUBLE, FAT SOLUBLE FATLTY ACIDS AND FATTY ALCOHOLS,
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US408600A US2776924A (en) | 1954-02-05 | 1954-02-05 | Composition of matter containing polyvinylpyrrolidone and a fatty carrier |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US408600A US2776924A (en) | 1954-02-05 | 1954-02-05 | Composition of matter containing polyvinylpyrrolidone and a fatty carrier |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| US2776924A true US2776924A (en) | 1957-01-08 |
Family
ID=23616940
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| US408600A Expired - Lifetime US2776924A (en) | 1954-02-05 | 1954-02-05 | Composition of matter containing polyvinylpyrrolidone and a fatty carrier |
Country Status (1)
| Country | Link |
|---|---|
| US (1) | US2776924A (en) |
Cited By (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2918411A (en) * | 1957-11-01 | 1959-12-22 | Olin Mathieson | Pharmaceutical preparations |
| US3102845A (en) * | 1960-11-18 | 1963-09-03 | Mcneilab Inc | Pharmaceutical tablet |
| US3152951A (en) * | 1960-11-18 | 1964-10-13 | Perlman Samuel Donald | Germicidal composition of iodine and liquid lanolin |
| US3544679A (en) * | 1968-06-24 | 1970-12-01 | Frederic C Mccoy | Paraffinic base oil carrier compositions for use in metal working and pesticides |
| US3671545A (en) * | 1969-05-05 | 1972-06-20 | Synergistics Inc | Polyvinylpyrrolidone-iodine compounds |
| US4130640A (en) * | 1974-09-10 | 1978-12-19 | Chazan Reuwen R | Germicidal cleaning compositions |
| WO1981000207A1 (en) * | 1979-07-11 | 1981-02-05 | P Harrigan | Pharmaceutical preparation |
| US4289749A (en) * | 1979-08-14 | 1981-09-15 | Key Pharmaceuticals, Inc. | Polymeric diffusion matrix containing phenylpropanolamine |
| US4291014A (en) * | 1979-01-11 | 1981-09-22 | Key Pharmaceuticals, Inc. | Polymeric diffusion matrix containing estradiol diacetate |
| US4482534A (en) * | 1980-12-16 | 1984-11-13 | Forest Laboratories, Inc. | Nitroglycerin preparations |
| US4604283A (en) * | 1984-04-24 | 1986-08-05 | Gresham Anne L | Hoof conditioner and dressing and methods of use |
| US4847078A (en) * | 1987-01-14 | 1989-07-11 | Arseco, Inc. | Storage stable topical composition having moisture control agent |
| US5128138A (en) * | 1989-07-21 | 1992-07-07 | Izhak Blank | Estradiol compositions and methods for topical application |
| US5209922A (en) * | 1992-03-19 | 1993-05-11 | Isp Investments Inc. | Water soluble polymers having antifungal properties |
| US5232703A (en) * | 1989-07-21 | 1993-08-03 | Izhak Blank | Estradiol compositions and methods for topical application |
| US6479076B2 (en) | 2001-01-12 | 2002-11-12 | Izhak Blank | Nicotine delivery compositions |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2022710A (en) * | 1933-12-29 | 1935-12-03 | Specialty Guild Inc | Process of coloring synthetic resin articles |
-
1954
- 1954-02-05 US US408600A patent/US2776924A/en not_active Expired - Lifetime
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2022710A (en) * | 1933-12-29 | 1935-12-03 | Specialty Guild Inc | Process of coloring synthetic resin articles |
Cited By (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2918411A (en) * | 1957-11-01 | 1959-12-22 | Olin Mathieson | Pharmaceutical preparations |
| US3102845A (en) * | 1960-11-18 | 1963-09-03 | Mcneilab Inc | Pharmaceutical tablet |
| US3152951A (en) * | 1960-11-18 | 1964-10-13 | Perlman Samuel Donald | Germicidal composition of iodine and liquid lanolin |
| US3544679A (en) * | 1968-06-24 | 1970-12-01 | Frederic C Mccoy | Paraffinic base oil carrier compositions for use in metal working and pesticides |
| US3671545A (en) * | 1969-05-05 | 1972-06-20 | Synergistics Inc | Polyvinylpyrrolidone-iodine compounds |
| US4130640A (en) * | 1974-09-10 | 1978-12-19 | Chazan Reuwen R | Germicidal cleaning compositions |
| US4291014A (en) * | 1979-01-11 | 1981-09-22 | Key Pharmaceuticals, Inc. | Polymeric diffusion matrix containing estradiol diacetate |
| WO1981000207A1 (en) * | 1979-07-11 | 1981-02-05 | P Harrigan | Pharmaceutical preparation |
| US4292303A (en) * | 1979-08-14 | 1981-09-29 | Key Pharmaceuticals, Inc. | Polymeric diffusion matrix containing clonidine |
| US4291015A (en) * | 1979-08-14 | 1981-09-22 | Key Pharmaceuticals, Inc. | Polymeric diffusion matrix containing a vasodilator |
| US4289749A (en) * | 1979-08-14 | 1981-09-15 | Key Pharmaceuticals, Inc. | Polymeric diffusion matrix containing phenylpropanolamine |
| US4292301A (en) * | 1979-08-14 | 1981-09-29 | Key Pharmaceuticals, Inc. | Polymeric diffusion matrix containing ephedrine |
| US4292302A (en) * | 1979-08-14 | 1981-09-29 | Key Pharmaceuticals, Inc. | Polymeric diffusion matrix containing terbutaline |
| US4294820A (en) * | 1979-08-14 | 1981-10-13 | Key Pharmaceuticals, Inc. | Polymeric diffusion matrix containing phenylephrine |
| US4482534A (en) * | 1980-12-16 | 1984-11-13 | Forest Laboratories, Inc. | Nitroglycerin preparations |
| US4604283A (en) * | 1984-04-24 | 1986-08-05 | Gresham Anne L | Hoof conditioner and dressing and methods of use |
| US4847078A (en) * | 1987-01-14 | 1989-07-11 | Arseco, Inc. | Storage stable topical composition having moisture control agent |
| US5128138A (en) * | 1989-07-21 | 1992-07-07 | Izhak Blank | Estradiol compositions and methods for topical application |
| US5232703A (en) * | 1989-07-21 | 1993-08-03 | Izhak Blank | Estradiol compositions and methods for topical application |
| US5209922A (en) * | 1992-03-19 | 1993-05-11 | Isp Investments Inc. | Water soluble polymers having antifungal properties |
| US6479076B2 (en) | 2001-01-12 | 2002-11-12 | Izhak Blank | Nicotine delivery compositions |
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