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US20220152614A1 - Aircraft galley insert with pathogens diagnostic test capabilities - Google Patents

Aircraft galley insert with pathogens diagnostic test capabilities Download PDF

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Publication number
US20220152614A1
US20220152614A1 US17/518,339 US202117518339A US2022152614A1 US 20220152614 A1 US20220152614 A1 US 20220152614A1 US 202117518339 A US202117518339 A US 202117518339A US 2022152614 A1 US2022152614 A1 US 2022152614A1
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US
United States
Prior art keywords
insert
module
sample
monument
aircraft
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US17/518,339
Inventor
Arnau Castillo Gonzalez
Antonio Martinez Murcia
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BE Aerospace Inc
Original Assignee
Koninklijke Fabriek Inventum BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Koninklijke Fabriek Inventum BV filed Critical Koninklijke Fabriek Inventum BV
Priority to US17/518,339 priority Critical patent/US20220152614A1/en
Assigned to KONINKLIJKE FABRIEK INVENTUM B.V. reassignment KONINKLIJKE FABRIEK INVENTUM B.V. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: MARTINEZ-MURCIA, ANTONIO, GONZALEZ, ARNAU CASTILLO
Publication of US20220152614A1 publication Critical patent/US20220152614A1/en
Assigned to B/E AEROSPACE, INC. reassignment B/E AEROSPACE, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: KONINKLIJKE FABRIEK INVENTUM B.V.
Priority to US18/982,817 priority patent/US20250116654A1/en
Abandoned legal-status Critical Current

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    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
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    • B64D13/00—Arrangements or adaptations of air-treatment apparatus for aircraft crew or passengers, or freight space
    • B64D13/06—Arrangements or adaptations of air-treatment apparatus for aircraft crew or passengers, or freight space the air being conditioned
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    • G01N1/22—Devices for withdrawing samples in the gaseous state
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Definitions

  • the present application is related to a system and method used to collect a representative air sample of an aircraft, more specifically to a method, and systems for analyzing a biological sample on an aircraft through a pathogen/contaminant diagnostic test such as real time PCR test.
  • a modular aircraft galley insert for performing pathogen/contaminant diagnostic testing such as thermal cycling for PCR testing includes a housing having, a sample module for receiving a sample to be tested, a sample concentration module, a purification and extraction module, a thermal module thermally connected to the sample module for cycling temperatures of the sample to be tested, a power module for providing power to the different modules, a detector module configured to analyze the amplified signal obtained from the sample and connected to receive power from the power module, the signal should be detected after each amplification cycle, and a connectivity module for communicating results of a test from the detector module to a remote location with respect to the housing.
  • a storage space can be located within the housing for storing for consumables and process waste.
  • the waste generated is not medical waste.
  • the consumables are inert, water based, and safe for the environmental.
  • the samples do not contain human biological information (DNA/RNA).
  • a second storage space can be present for storing the tested sample.
  • a module for sample automatic loading This module is configured to transfer a portion of the purified sample through a micro-pipette tip propelled by a pump and this aliquot deposited over each vessel to run PCR test.
  • the power rating of the insert is about 1000 W.
  • a volume of the insert is sized to fit within a galley ARINC size between 4 and 6.
  • the insert can operate independently of the cabin pressure ranges or other environmental conditions in the aircraft.
  • the insert can be inserted within a galley monument for a cabin area of an aircraft, where the monument includes, a first monument stack, a second monument stack adjacent to the first monument stack, a tray within the second monument stack to secure the insert.
  • the connectivity module can be connected to a cockpit of an aircraft.
  • the power module can be connected to an aircraft power source.
  • the insert can be integrated within a monument stack, or the insert can be removably attached to a monument stack.
  • FIG. 1 is an isometric view of an insert for PCR testing according to the disclosure.
  • FIG. 2 is a schematic view of the modules of the insert.
  • FIG. 1 a partial view of an exemplary embodiment of a system in accordance with the disclosure is shown in FIG. 1 and is designated generally by reference character 100 .
  • the system described below is used to test a bulk sample, representative of all passengers on the aircraft and to test it to provide a bulk screening of the aircraft prior to arrival of the aircraft at a destination.
  • FIG. 1 shows a modular aircraft galley insert 100 for performing thermal cycling for PCR testing.
  • a storage space 114 is located within the housing 104 for storing for consumables and waste. The waste generated is not medical waste. The consumables are inert, water based, and safe for the environmental.
  • a second storage space 116 can be present for storing the tested sample after a test is complete.
  • the insert 102 is inserted within a galley monument 118 .
  • the monument 118 includes a first monument stack 120 , a second monument 122 stack adjacent to the first monument stack 120 , and a tray 126 within the second monument stack 124 to secure the insert 102 .
  • the power rating of the insert 100 is about 1000 W.
  • a volume of the insert is sized to fit within a galley ARINC size between 4 and 6.
  • the insert can operate independently of the cabin pressure ranges or other environmental conditions in the aircraft.
  • the insert 100 includes a housing 102 that includes a sample module 104 for receiving a sample to be tested, a thermal module 106 thermally connected to the sample module 104 for cycling temperatures of the sample to be tested, a power module 108 for providing power to the thermal module, a detector module 110 configured to analyze the sample and connected to receive power from the power module 108 , and a connectivity module 112 for communicating results of a test from the detector module 110 to a remote location with respect to the housing 102 .
  • the connectivity module 112 is be connected to a cockpit of an aircraft in order to relay the results of the test to the crew and pilots. It is also considered that the connectivity module is connected to communicate to a destination or origin airport to relay the results of the test.
  • the power module 108 can be connected to an aircraft power source.
  • the reagents that are present within the insert 102 are mixed, and stable at room temperatures.
  • Reagents will be pathogen-specific, that is, a determined set of reagents for each specific pathogen to be detected.
  • Protocols for running programs are programed in the unit for PCR cycling: a few examples are the setup Temperatures of the specific thermal cycle, timing or number of cycles; in the case of the thermal module.
  • the methods and systems of the present disclosure provide for an improved bulk data and analysis of passenger pathogens on an aircraft.
  • the system provides a more efficient primary health controls at airports, helps identify at early stages emerging pathogens and origin of outbreaks, and empower their scientific research (either academic and/or commercial / institutional).

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Clinical Laboratory Science (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Theoretical Computer Science (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Evolutionary Biology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Databases & Information Systems (AREA)
  • Bioethics (AREA)
  • Hematology (AREA)
  • Aviation & Aerospace Engineering (AREA)
  • Toxicology (AREA)
  • Pulmonology (AREA)
  • Public Health (AREA)
  • Hydrology & Water Resources (AREA)
  • Artificial Intelligence (AREA)
  • Computer Vision & Pattern Recognition (AREA)

Abstract

A modular aircraft galley insert for performing thermal cycling for PCR testing includes a housing having a sample module for receiving a sample to be tested, a thermal module thermally connected to the sample module for cycling temperatures of the sample to be tested, a power module for providing power to the thermal module, a detector module configured to analyze the sample and connected to receive power from the power module, and a connectivity module for communicating results of a test from the detector module to a remote location with respect to the housing.

Description

    PRIORITY CLAIM
  • The following application claims priority to U.S. Provisional Patent Applications with the following Ser. Nos. 63/114,330, 63/114,339, 63/114,350, 63/114,400, 63,114,064, 63/114,157, 63/114,386, 63/114,366 all filed on Nov. 16, 2020; and Patent Application Ser. No. 63/043,414 filed on Jun. 24, 2020 the contents of which are herein incorporated by reference in their entirety.
    • BACKGROUND Technological Field
  • The present application is related to a system and method used to collect a representative air sample of an aircraft, more specifically to a method, and systems for analyzing a biological sample on an aircraft through a pathogen/contaminant diagnostic test such as real time PCR test.
    • Description of Related Art
  • The spread progression of SARS-CoV-2 around the world has risen a red flag: Economic economic globalization creates systemic risks. As trade, finance, travel, cyber and other networks grow in scale and interact, they become more complex and unstable. The transporters of the goods of the global economy, such as major airport hubs, are also spreaders of the pathogens. The 2008 global financial crisis provided a dramatic example of how contagions could spread from the US to global markets overnight. So too has the rapid spread of cyber viruses. In health, rising life expectancy and success in preventing a repeat of the devastating influenza pandemic of 1918, which infected about one-third of the world's population and killed as many as 50 m people, has created a false sense of security. But the world is now more interdependent. For example, China represents almost one-fifth of global output, is integral to global supply chains, and its tourists spend over $260 billion annually. The CovidCOVID-19CoVID-19 pandemic shed light on the need for better monitoring, detecting, and isolating ill passengers, specifically due to the havoc that was wreaked detrimental impact on the global economy, specifically air travel due to closed borders, movement restrictions, and testing requirements.
  • However, the COVIDCoVID-19 pandemic the air travel industry has proven that air travel can be safe and that aircraft cabins have a well-managed airflow that inhibits minimize the risk for transmission of virus, and that being seated onboard an aircraft is safer than shopping in large stores. Governments and other authorities need to assume that aircraft are contaminated until proven “clean”, as 25% of COVID-19 cases are asymptomatic or pre-symptomatic; but still contagious. Thus, if borders shutdown and a drastic reduction in international travel global passenger travel is greatly reduced. To date travelers and governments have relied on individual diagnostic tests. The uncertainty of the results has reduced people's inclination to travel and subsequent airline inclination to maintain routes.
  • Accordingly, conventional systems and methods of monitoring infections has not lived up to requirements of the fast-paced modern world. Thus, there is still a need in the art for an improved on-board virus and pathogen detection system. The present disclosure provides a solution for this need.
    • SUMMARY OF THE INVENTION
  • A modular aircraft galley insert for performing pathogen/contaminant diagnostic testing such as thermal cycling for PCR testing is disclosed. The insert includes a housing having, a sample module for receiving a sample to be tested, a sample concentration module, a purification and extraction module, a thermal module thermally connected to the sample module for cycling temperatures of the sample to be tested, a power module for providing power to the different modules, a detector module configured to analyze the amplified signal obtained from the sample and connected to receive power from the power module, the signal should be detected after each amplification cycle, and a connectivity module for communicating results of a test from the detector module to a remote location with respect to the housing.
  • A storage space can be located within the housing for storing for consumables and process waste. The waste generated is not medical waste. The consumables are inert, water based, and safe for the environmental. The samples do not contain human biological information (DNA/RNA). A second storage space can be present for storing the tested sample. A module for sample automatic loading. This module is configured to transfer a portion of the purified sample through a micro-pipette tip propelled by a pump and this aliquot deposited over each vessel to run PCR test.
  • The power rating of the insert is about 1000 W. A volume of the insert is sized to fit within a galley ARINC size between 4 and 6. The insert can operate independently of the cabin pressure ranges or other environmental conditions in the aircraft. The insert can be inserted within a galley monument for a cabin area of an aircraft, where the monument includes, a first monument stack, a second monument stack adjacent to the first monument stack, a tray within the second monument stack to secure the insert.
  • The connectivity module can be connected to a cockpit of an aircraft. The power module can be connected to an aircraft power source. The insert can be integrated within a monument stack, or the insert can be removably attached to a monument stack.
  • These and other features of the systems and methods of the subject disclosure will become more readily apparent to those skilled in the art from the following detailed description of the preferred embodiments taken in conjunction with the drawings.
    • BRIEF DESCRIPTION OF THE DRAWINGS
  • So that those skilled in the art to which the subject disclosure appertains will readily understand how to make and use the devices and methods of the subject disclosure without undue experimentation, embodiments thereof will be described in detail herein below with reference to certain figures, wherein:
  • FIG. 1 is an isometric view of an insert for PCR testing according to the disclosure; and
  • FIG. 2 is a schematic view of the modules of the insert.
    •  DETAILED DESCRIPTION
  • Reference will now be made to the drawings wherein like reference numerals identify similar structural features or aspects of the subject disclosure. For purposes of explanation and illustration, and not limitation, a partial view of an exemplary embodiment of a system in accordance with the disclosure is shown in FIG. 1 and is designated generally by reference character 100. The system described below is used to test a bulk sample, representative of all passengers on the aircraft and to test it to provide a bulk screening of the aircraft prior to arrival of the aircraft at a destination.
  • FIG. 1 shows a modular aircraft galley insert 100 for performing thermal cycling for PCR testing. A storage space 114 is located within the housing 104 for storing for consumables and waste. The waste generated is not medical waste. The consumables are inert, water based, and safe for the environmental. A second storage space 116 can be present for storing the tested sample after a test is complete. The insert 102 is inserted within a galley monument 118. The monument 118 includes a first monument stack 120, a second monument 122 stack adjacent to the first monument stack 120, and a tray 126 within the second monument stack 124 to secure the insert 102.
  • The power rating of the insert 100 is about 1000 W. A volume of the insert is sized to fit within a galley ARINC size between 4 and 6. The insert can operate independently of the cabin pressure ranges or other environmental conditions in the aircraft.
  • Referring to FIG. 2, the insert 100 includes a housing 102 that includes a sample module 104 for receiving a sample to be tested, a thermal module 106 thermally connected to the sample module 104 for cycling temperatures of the sample to be tested, a power module 108 for providing power to the thermal module, a detector module 110 configured to analyze the sample and connected to receive power from the power module 108, and a connectivity module 112 for communicating results of a test from the detector module 110 to a remote location with respect to the housing 102.The connectivity module 112 is be connected to a cockpit of an aircraft in order to relay the results of the test to the crew and pilots. It is also considered that the connectivity module is connected to communicate to a destination or origin airport to relay the results of the test. The power module 108 can be connected to an aircraft power source.
  • The reagents that are present within the insert 102, being ready to use, are mixed, and stable at room temperatures. Reagents will be pathogen-specific, that is, a determined set of reagents for each specific pathogen to be detected. Protocols for running programs are programed in the unit for PCR cycling: a few examples are the setup Temperatures of the specific thermal cycle, timing or number of cycles; in the case of the thermal module.
  • The methods and systems of the present disclosure, as described above and shown in the drawings, provide for an improved bulk data and analysis of passenger pathogens on an aircraft. The system provides a more efficient primary health controls at airports, helps identify at early stages emerging pathogens and origin of outbreaks, and empower their scientific research (either academic and/or commercial / institutional).While the apparatus and methods of the subject disclosure have been shown and described with reference to preferred embodiments, those skilled in the art will readily appreciate that changes and/or modifications may be made thereto without departing from the scope of the subject disclosure.

Claims (15)

What is claimed is:
1. A modular aircraft galley insert for performing thermal cycling for PCR testing comprising:
a housing having:
a sample module for receiving a sample to be tested;
a thermal module thermally connected to the sample module for cycling temperatures of the sample to be tested;
a power module for providing power to the thermal module;
a detector module configured to analyze the sample and connected to receive power from the power module; and
a connectivity module for communicating results of a test from the detector module to a remote location with respect to the housing.
2. The insert of claim 1, further comprising a first storage space storing for consumables and process waste materials within the housing.
3. The inset of claim 1, further comprising a second storage space for storing the tested sample.
4. The insert of claim 1, further comprising a loading module for sample automatic loading and configured to transfer a portion of a test sample through a pipette tip for testing purposes.
5. The insert of claim 4, wherein the loading module further comprises a pump.
6. The insert of claim 4, wherein the loading module further comprises a pipette.
7. The inset of claim 1, wherein the power rating of the insert is approximately 1000 W.
8. The insert of claim 1, wherein further comprising a plurality of testing vessels configured to receive an individual sample within the housing.
9. The insert of claim 1, wherein the insert is configured to operate independently of the cabin pressure ranges or other environmental conditions in the aircraft.
10. The insert of claim 1, wherein the insert is inserted within a galley monument for a cabin area of an aircraft, where the monument includes:
a first monument stack;
a second monument stack adjacent to the first monument stack; and
a tray within the second monument stack to secure the insert.
11. The insert of claim 1, wherein the connectivity module is connected to a cockpit of an aircraft.
12. The insert of claim 1, wherein the connectivity module is connected to an on on-ground-receiver.
13. The inset of claim 1, wherein the power module is connected to an aircraft power source.
14. The insert of claim 1, wherein the insert is integrated within a monument stack.
15. The insert of claim 1, wherein the insert is removably attached to a monument stack.
US17/518,339 2020-11-16 2021-11-03 Aircraft galley insert with pathogens diagnostic test capabilities Abandoned US20220152614A1 (en)

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US202063114386P 2020-11-16 2020-11-16
US202063114339P 2020-11-16 2020-11-16
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US202063114400P 2020-11-16 2020-11-16
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US17/518,342 Abandoned US20220155188A1 (en) 2020-11-16 2021-11-03 Methods to obtain a biological sample representative of a passenger cabin on an aircraft automatically from the collector device
US17/518,339 Abandoned US20220152614A1 (en) 2020-11-16 2021-11-03 Aircraft galley insert with pathogens diagnostic test capabilities
US17/518,332 Active 2044-06-13 US12429475B2 (en) 2020-11-16 2021-11-03 Methods and systems for capturing biological samples from a HEPA filter on an aircraft
US17/518,458 Abandoned US20220155280A1 (en) 2020-11-16 2021-11-03 Systems and methods for collecting a biological sample from a passenger cabin
US17/518,329 Pending US20220155187A1 (en) 2020-11-16 2021-11-03 Methods of obtaining a biological sample representative of a passenger cabin on an aircraft using an air cyclonic collector
US17/518,476 Pending US20220155189A1 (en) 2020-11-16 2021-11-03 Systems and methods for collecting a biological sample from a passenger cabin
US18/982,817 Pending US20250116654A1 (en) 2020-11-16 2024-12-16 Aircraft galley insert with pathogens diagnostic test capabilities
US19/229,179 Pending US20250298005A1 (en) 2020-11-16 2025-06-05 Methods to obtain a biological sample representative of a passenger cabin on an aircraft automatically from the collector device

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US17/518,329 Pending US20220155187A1 (en) 2020-11-16 2021-11-03 Methods of obtaining a biological sample representative of a passenger cabin on an aircraft using an air cyclonic collector
US17/518,476 Pending US20220155189A1 (en) 2020-11-16 2021-11-03 Systems and methods for collecting a biological sample from a passenger cabin
US18/982,817 Pending US20250116654A1 (en) 2020-11-16 2024-12-16 Aircraft galley insert with pathogens diagnostic test capabilities
US19/229,179 Pending US20250298005A1 (en) 2020-11-16 2025-06-05 Methods to obtain a biological sample representative of a passenger cabin on an aircraft automatically from the collector device

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