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US20190144406A1 - Crystalline forms of dimethoxy docetaxel and methods for preparing the same - Google Patents

Crystalline forms of dimethoxy docetaxel and methods for preparing the same Download PDF

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US20190144406A1
US20190144406A1 US16/188,687 US201816188687A US2019144406A1 US 20190144406 A1 US20190144406 A1 US 20190144406A1 US 201816188687 A US201816188687 A US 201816188687A US 2019144406 A1 US2019144406 A1 US 2019144406A1
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hydroxy
dimethoxy
benzoyloxy
acetoxy
tert
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Pascal Billot
Marielle Dufraigne
Hagit Elmaleh
Fabrice Mangin
Patricia RORTAIS
Lionel Zaske
Alexandre Giuliani
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Aventis Pharma SA
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
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    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • the present invention relates to crystalline forms of dimethoxy docetaxel or 4-acetoxy-2 ⁇ -benzoyloxy-5 ⁇ ,20-epoxy-1-hydroxy-7 ⁇ , 10 ⁇ -dimethoxy-9-oxotax-11-en-13 ⁇ -yl (2R,3S)-3-tert-butoxycarbonylamino-2-hydroxy-3-phenylpropionate and to methods for the preparation thereof.
  • the present invention relates to new crystalline forms, with the exclusion of the acetonate form, the only one known to date.
  • FIG. 1 depicts a Differential Scanning calorimetry (DSC) analysis for anhydrous form D.
  • DSC Differential Scanning calorimetry
  • FIG. 2 depicts a Powder X-Ray Diffraction (PXRD) analysis for anhydrous form D.
  • PXRD Powder X-Ray Diffraction
  • FIG. 3 depicts Fourier Transform InfraRed (FTIR) spectrometry analysis for anhydrous form D.
  • FTIR Fourier Transform InfraRed
  • FIG. 4 depicts a Powder X-Ray Diffraction (PXRD) analysis for ethanolate form D.
  • PXRD Powder X-Ray Diffraction
  • FIG. 5 depicts a Powder X-Ray Diffraction (PXRD) analysis for ethanolate form E.
  • PXRD Powder X-Ray Diffraction
  • nonethanolic, solvates of the form B were prepared, such as in particular those obtained with the following solvents: dichloromethane, diisopropyl ether, n-propanol, isopropanol, toluene, methyl isobutyl ketone, tetrahydrofuran, dimethylformamide, ethyl acetate, etc.
  • the measurements were carried out on a T.A. Instruments DSC2010 thermal analyser.
  • the sample is subjected to temperature programming from 25° C. to 225° C. with a heating rate of 5° C./min.
  • the product is placed in a crimped aluminium capsule and the amount of product analysed is between 2 and 5 mg. Constant nitrogen sweeping at 55 mL/min is used in the oven chamber.
  • the analyses were carried out on a Panalytical X'Pert Pro diffractometer with a reflection-mode Bragg-Brentano focusing geometry ( ⁇ -2 ⁇ ) assembly.
  • the product analysed is deposited as a thin layer on a silicon single crystal.
  • the beam is collimated using Sollers slits which improve the parallelism and variable slits which limit scattering.
  • An X'Celerator detector completes the device.
  • the diagram recording characteristics are the following: sweeping from 2 to 30 degrees 2 ⁇ , counting time from 100 to 500 seconds per step with a step of 0.017°.
  • the solid samples were analysed using a Nicolet Nexus spectrometer.
  • the analysis is carried out by attenuated total reflectance (ATR) using a Smart Orbit accessory from the company Thermo (single reflection diamond crystal ATR accessory).
  • the spectral range swept is between 4000 and 400 cm ⁇ 1 with a resolution of 2 cm ⁇ 1 and an accumulated scan number of 20.

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Abstract

The invention relates to anhydrides, solvates and ethanol hetero-solvates and hydrates of dimethoxy docetaxel or (2R,3S)-3-tert-butoxycarbonylamino-2-hydroxy-3-phenyl-propionate of 4-acetoxy-2α-benzoyloxy-5β,20-epoxy-1-hydroxy-7β, 10β-dimethoxy-9-oxo-tax-11-ene-13α-yle, and to the preparation thereof.

Description

  • This application is a divisional of U.S. patent application Ser. No. 15/646,375, filed Jul. 11, 2017, which is a divisional application of U.S. patent application Ser. No. 14/453,087, filed Aug. 6, 2014, which is a divisional application of U.S. patent application Ser. No. 13/767,966, filed Feb. 15, 2013, now U.S. Pat. No. 8,846,959, which is a divisional application of U.S. patent application Ser. No. 12/837,559 filed Jul. 16, 2010, now U.S. Pat. No. 8,378,128, which is a continuation of International Patent Application PCT/FR2009/000042 filed Jan. 15, 2009, all of which are incorporated herein by reference; and which claim priority to French Patent Application No. 0800243 filed on Jan. 17, 2008.
  • The present invention relates to crystalline forms of dimethoxy docetaxel or 4-acetoxy-2α-benzoyloxy-5β,20-epoxy-1-hydroxy-7β, 10β-dimethoxy-9-oxotax-11-en-13α-yl (2R,3S)-3-tert-butoxycarbonylamino-2-hydroxy-3-phenylpropionate and to methods for the preparation thereof.
    • BACKGROUND OF THE INVENTION
  • 4-Acetoxy-2α-benzoyloxy-5β, 20-epoxy-1-hydroxy-7β, 10β-dimethoxy-9-oxotax-11-en-13α-yl (2R,3S)-3-tert-butoxycarbonylamino-2-hydroxy-3-phenylpropionate exhibits notable anticancer and antileukaemic properties.
  • 4-Acetoxy-2α-benzoyloxy-5β, 20-epoxy-1-hydroxy-7β, 10β-di methoxy-9-oxotax-11-en-13α-yl (2R,3S)-3-tert-butoxycarbonylamino-2-hydroxy-3-phenylpropionate is prepared according to the method which is described more particularly in PCT International Application WO 96/30355 or PCT International Application WO 99/25704. According to the method described in these applications, the product is not crystallized and is not characterized.
  • It was found that the acetone solvate of 4-acetoxy-2α-benzoyloxy-5β,20-epoxy-1-hydroxy-7β, 10β-dimethoxy-9-oxotax-11-en-13α-yl (2R,3S)-3-tert-butoxycarbonylamino-2-hydroxy-3-phenylpropionate (called form A) was completely determined and characterized according to the patent published under number WO2005/028462.
    • BRIEF SUMMARY OF THE INVENTION
  • The present invention relates to new crystalline forms, with the exclusion of the acetonate form, the only one known to date.
  • According to the present invention, it has now been found that certain anhydrous forms, certain ethanolic solvates or heterosolvates and hydrated forms have been completely characterized from a physical and chemical structure point of view.
    • BRIEF DESCRIPTION OF THE DRAWINGS
  • FIG. 1 depicts a Differential Scanning calorimetry (DSC) analysis for anhydrous form D.
  • FIG. 2 depicts a Powder X-Ray Diffraction (PXRD) analysis for anhydrous form D.
  • FIG. 3 depicts Fourier Transform InfraRed (FTIR) spectrometry analysis for anhydrous form D.
  • FIG. 4 depicts a Powder X-Ray Diffraction (PXRD) analysis for ethanolate form D.
  • FIG. 5 depicts a Powder X-Ray Diffraction (PXRD) analysis for ethanolate form E.
    •  DETAILED DESCRIPTION OF THE INVENTION
  • According to the invention, among the anhydrous forms of 4-acetoxy-2α-benzoyloxy-5β,20-epoxy-1-hydroxy-7β,10β-dimethoxy-9-oxotax-11-en-13α-yl(2R,3S)-3-tert-butoxycarbonylamino-2-hydroxy-3-phenylpropionate, five different forms have been identified, among the ethanolic solvates or heterosolvates of 4-acetoxy-2α-benzoyloxy-5β,20-epoxy-1-hydroxy-7β,10β-dimethoxy-9-oxotax-11-en-13α-yl(2R,3S)-3-tert-butoxy c arb onyl amino-2-hydroxy-3-phenylpropionate, four different forms have been identified and among the hydrates of 4-acetoxy-2α-benzoyloxy-5β,20-epoxy-1-hydroxy-7β,10β-dimethoxy-9-oxotax-11-en-13α-yl (2R,3S)-3-tert-butoxycarbonylamino-2-hydroxy-3-phenylpropionate, two different forms have been identified.
  • The five anhydrous forms identified were obtained according to the following methods:
      • The anhydrous form B by a method which consists in heating the acetone form or form A obtained according to the patent mentioned above, between 100 and 110° C. under vacuum or nitrogen sweeping. This treatment is preferably carried out for at least 9 hours before a return to ambient temperature without inducing chemical decomposition. Its melting point by DSC is approximately 150° C. The PXRD diagram of the anhydrous form B exhibits characteristic lines located at 7.3, 8.1, 9.8, 10.4, 11.1, 12.7, 13.1, 14.3, 15.4 and 15.9±0.2 degrees 2-theta.
      • The anhydrous form C is obtained by maturation of the acetone solvate form A, or of the anhydrous form B, in water followed by drying at up to 50° C. and maintaining between 0 and 5% RH at ambient temperature. Its melting point by DSC is approximately 146° C. The PXRD diagram of the anhydrous form C exhibits characteristic lines located at 4.3, 6.8, 7.4, 8.7, 10.1, 11.1, 11.9, 12.3, 12.6 and 13.1±0.2 degrees 2-theta. It is, among the various anhydrous forms, the least stable of all the forms described in the present invention. In the presence of a relative humidity of greater than 5%, it changes to a hydrated form.
      • The anhydrous form D is obtained according to a first method by crystallization of the form A in an oil (especially Miglyol), following by rinsing with an alkane, for example heptane; the second preparation method consists in leaving a solution of 4-acetoxy-2α-benzoyloxy-5β,20-epoxy-1-hydroxy-7β,10β-dimethoxy-9-oxotax-11-en-13α-yl (2R,3S)-3-tert-butoxycarbonylamino-2-hydroxy-3-phenylpropionate in a mixture of Polysorbate 80, pH 3.5, ethanol and water (preferably a 25/25/50 mixture) to crystallize for approximately 48 hours. Its boiling point by DSC is approximately 175° C. (cf. FIG. 1) and is found to be the highest of all the anhydrous forms isolated. The PXRD diagram of the anhydrous form D (cf. FIG. 2) exhibits characteristic lines located at 3.9, 7.7, 7.8, 7.9, 8.6, 9.7, 10.6, 10.8, 11.1 and 12.3±0.2 degrees 2-theta. The FTIR spectrum of the anhydrous form D exhibits characteristic bands located at 979, 1072, 1096, 1249, 1488, 1716, 1747, 3436±1 cm−1 (cf. FIG. 3). Among all the forms described in the present invention, it is the most stable anhydrous form.
      • The anhydrous form E is obtained at ambient temperature by maturation of the acetone form or form A in ethanol so as to intermediately form an ethanolic form which is subsequently desolvated under nitrogen sweeping or by heating at approximately 100° C. for 2 hours. Its melting point by DSC is approximately 157° C. The PXRD diagram of the anhydrous form E exhibits characteristic lines located at 7.1, 8.1, 8.9, 10.2, 10.8, 12.5, 12.7, 13.2, 13.4 and 13.9±0.2 degrees 2-theta.
      • The anhydrous form F is obtained by desolvating the ethanol/water heterosolvate at 120° C. under a nitrogen atmosphere for 24 hours and then maintaining in a dry environment at 0% RH at ambient temperature. Its melting point by DSC is approximately 148° C. The PXRD diagram of the anhydrous form F exhibits characteristic lines located at 4.4, 7.2, 8.2, 8.8, 9.6, 10.2, 10.9, 11.2, 12.1 and 12.3±0.2 degrees 2-theta.
  • There are four crystalline forms identified in ethanolic solvate or heterosolvate form:
      • The ethanolate form B is obtained at ambient temperature by maintaining the anhydrous form B in an ethanol-vapour-saturated environment. The PXRD diagram of the ethanolate form B exhibits characteristic lines located at 7.3, 7.8, 8.8, 10.2, 12.6, 12.9, 13.4, 14.2, 14.7 and 15.1±0.2 degrees 2-theta.
      • The ethanolate form D is obtained at ambient temperature by maintaining the anhydrous form D in an ethanol-vapour-saturated environment. The PXRD diagram of the ethanolate form D (cf. FIG. 4) exhibits characteristic lines located at 3.8, 7.5, 7.7, 8.4, 9.4, 10.3, 10.5, 11.1, 11.5 and 11.9±0.2 degrees 2-theta.
      • The ethanolate form E is obtained at ambient temperature by maturation of the acetonate form A in ethanol. The PXRD diagram of the ethanolate form E (cf. FIG. 5) exhibits characteristic lines located at 7.1, 8.1, 8.8, 10.2, 10.7, 12.5, 13.2, 13.4, 13.9 and 14.2±0.2 degrees 2-theta.
      • The ethanol/water heterosolvate form F is obtained by maintaining the form B in a minimum amount of ethanol at reflux, slow cooling and isolation at ambient temperature and ambient relative humidity. The PXRD diagram of the ethanol/water heterosolvate form F exhibits characteristic lines located at 4.4, 7.2, 8.2, 8.3, 8.8, 9.6, 10.3, 10.9, 11.2 and 12.2±0.2 degrees 2-theta.
  • There are two crystalline forms identified in hydrate form:
      • The monohydrated forms C are obtained at ambient temperature by maintaining the anhydrous form C in an atmosphere containing at least 10% relative humidity. The PXRD diagram of the monohydrate form C exhibits characteristic lines located at 4.3, 6.8, 7.4, 8.6, 10.1, 11.1, 11.9, 12.2, 12.6 and 13.3±0.2 degrees 2-theta.
      • The dihydrate form C is obtained at ambient temperature by maintaining the anhydrous form C in an atmosphere containing at least 60% relative humidity. The PXRD diagram of the dihydrate form C exhibits characteristic lines located at 4.2, 6.9, 7.5, 8.4, 9.9, 10.9, 11.7, 12.3, 12.6 and 13.2±0.2 degrees 2-theta.
  • Other, nonethanolic, solvates of the form B were prepared, such as in particular those obtained with the following solvents: dichloromethane, diisopropyl ether, n-propanol, isopropanol, toluene, methyl isobutyl ketone, tetrahydrofuran, dimethylformamide, ethyl acetate, etc.
  • The present invention will be described more fully by means of the following examples which should not be considered to limit the invention.
  • Experimental Analysis Conditions:
  • Differential Scanning Calorimetry (DSC):
  • The measurements were carried out on a T.A. Instruments DSC2010 thermal analyser. The sample is subjected to temperature programming from 25° C. to 225° C. with a heating rate of 5° C./min. The product is placed in a crimped aluminium capsule and the amount of product analysed is between 2 and 5 mg. Constant nitrogen sweeping at 55 mL/min is used in the oven chamber.
  • Powder X-Ray Diffraction (PXRD):
  • The analyses were carried out on a Panalytical X'Pert Pro diffractometer with a reflection-mode Bragg-Brentano focusing geometry (θ-2θ) assembly. The product analysed is deposited as a thin layer on a silicon single crystal. A copper anticathode tube (45 kV/40 mA) supplies an incident radiation Cu Kα1 (λ=1.5406 Å). The beam is collimated using Sollers slits which improve the parallelism and variable slits which limit scattering. An X'Celerator detector completes the device. The diagram recording characteristics are the following: sweeping from 2 to 30 degrees 2θ, counting time from 100 to 500 seconds per step with a step of 0.017°.
  • Fourier Transform InfraRed (FTIR) Spectrometry:
  • The solid samples were analysed using a Nicolet Nexus spectrometer. The analysis is carried out by attenuated total reflectance (ATR) using a Smart Orbit accessory from the company Thermo (single reflection diamond crystal ATR accessory). The spectral range swept is between 4000 and 400 cm−1 with a resolution of 2 cm−1 and an accumulated scan number of 20.
    • Example 1
  • Two tests of dissolution of approximately 550 mg of 4-acetoxy-2α-benzoyloxy-5β,20-epoxy-1-hydroxy-7β,10β-dimethoxy-9-oxotax-11-en-13α-yl (2R,3S)-3-tert-butoxycarbonylamino-2-hydroxy-3-phenylpropionate in 14 g of Miglyol 812 Neutral oil, Sasol are carried out. Magnetic stirring is carried out at 500 rpm for 24 hours at ambient temperature.
  • After one week, the samples are vacuum-filtered and rinsed with heptane. Each sample is analysed by PXRD for confirmation of the form obtained. After filtration, between 300 and 350 mg of anhydrous form D are obtained.
    • Example 2
  • Approximately 3 g of 4-acetoxy-2α-benzoyloxy-5β,20-epoxy-1-hydroxy-70,100-dimethoxy-9-oxotax-11-en-13α-yl (2R,3S)-3-tert-butoxycarbonylamino-2-hydroxy-3-phenyl-propionate are dissolved in a mixture of 50 mL ethanol+50 mL Polysorbate 80, pH 3.5. 100 mL of water are added to the previous mixture and the whole is homogenized. After storage for 48 hours at ambient temperature, crystals of anhydrous form D appeared. The amount of crystallized product recovered by filtration is approximately 2.45 g.
  • A comparative stability study was carried out between the acetone solvate form A and the anhydrous form D. The comparison of the PXRD analyses carried out on the A and D forms immediately after production and after having maintained said forms at 40° C. for one month gives the following results:
      • Form A: partial desolvation resulting in a mixture of the acetone solvate form A and of the anhydrous form B being obtained.
      • Form D: no change detected after maintaining at 40° C. for one month.

Claims (22)

1. Crystalline forms of 4-acetoxy-2a-benzoyloxy-5b,20-epoxy-1-hydroxy-7β,10β-dimethoxy-9-oxotax-11-en-13a-yl (2R,3S)-3-tert-butoxycarbonylamino-2-hydroxy-3-phenylpropionate, with the exception of the acetonate form.
2. Forms according to claim 1, characterized in that they are anhydrous forms of 4-acetoxy-2a-benzoyloxy-5b,20-epoxy-1-hydroxy-7β,10β-dimethoxy-9-oxotax-11-en-13a-yl (2R,3S)-3-tert-butoxycarbonylamino-2-hydroxy-3-phenylpropionate.
3. (canceled)
4. Anhydrous form C of 4-acetoxy-2α-benzoyloxy-5b,20-epoxy-1-hydroxy-7β,10β-dimethoxy-9-oxotax-11-en-13a-yl (2R,3S)-3-tert-butoxycarbonylamino-2-hydroxy-3-phenylpropionate according to claim 2, characterized by a PXRD diagram exhibiting characteristic lines located at 4.3, 6.8, 7.4, 8.7, 10.1, 11.1, 11.9, 12.3, 12.6 and 13.1±0.2 degrees 2-theta.
5. (canceled)
6. Anhydrous form E of 4-acetoxy-2a-benzoyloxy-5b,20-epoxy-1-hydroxy-7β,10β-dimethoxy-9-oxotax-11-en-13a-yl (2R,3S)-3-tert-butoxycarbonylamino-2-hydroxy-3-phenylpropionate according to claim 2, characterized by a PXRD diagram exhibiting characteristic lines located at 7.1, 8.1, 8.9, 10.2, 10.8, 12.5, 12.7, 13.2, 13.4 and 13.9±0.2 degrees 2-theta.
7. (canceled)
8. Forms according to claim 1, characterized in that they are ethanolic solvate or heterosolvate forms of 4-acetoxy-2a-benzoyloxy-5b,20-epoxy-1-hydroxy-7β,10β-dimethoxy-9-oxotax-11-en-13a-yl (2R,3S)-3-tert-butoxycarbonylamino-2-hydroxy-3-phenylpropionate.
9. Ethanolate form B of 4-acetoxy-2a-benzoyloxy-5b,20-epoxy-1-hydroxy-7β,10β-dimethoxy-9-oxotax-11-en-13a-yl (2R,3S)-3-tert-butoxycarbonylamino-2-hydroxy-3-phenylpropionate according to claim 8, characterized by a PXRD diagram exhibiting characteristic lines located at 7.3, 7.8, 8.8, 10.2, 12.6, 12.9, 13.4, 14.2, 14.7 and 15.1±0.2 degrees 2-theta.
10. Ethanolate form D of 4-acetoxy-2a-benzoyloxy-5b,20-epoxy-1-hydroxy-7β,10β-dimethoxy-9-oxotax-11-en-13a-yl (2R,3S)-3-tert-butoxycarbonylamino-2-hydroxy-3-phenylpropionate according to claim 8, characterized by a PXRD diagram exhibiting characteristic lines located at 3.8, 7.5, 7.7, 8.4, 9.4, 10.3, 10.5, 11.1, 11.5 and 11.9±0.2 degrees 2-theta.
11. (canceled)
12. Ethanol/water heterosolvate form F of 4-acetoxy-2a-benzoyloxy-5b,20-epoxy-1-hydroxy-7β,10β-dimethoxy-9-oxotax-11-en-13a-yl (2R,3S)-3-tert-butoxy-carbonylamino-2-hydroxy-3-phenylpropionate according to claim 8, characterized by a PXRD diagram exhibiting characteristic lines located at 4.4, 7.2, 8.2, 8.3, 8.8, 9.6, 10.3, 10.9, 11.2 and 12.2±0.2 degrees 2-theta.
13. Forms according to claim 1, characterized in that they are hydrate forms of 4-acetoxy-2a-benzoyloxy-5b,20-epoxy-1-hydroxy-7p,10β-dimethoxy-9-oxotax-11-en-13a-yl (2R,3S)-3-tert-butoxycarbonylamino-2-hydroxy-3-phenylpropionate.
14. Monohydrate form C of 4-acetoxy-2a-benzoyloxy-5b,20-epoxy-1-hydroxy-7β,10β-dimethoxy-9-oxotax-11-en-13a-yl (2R,3S)-3-tert-butoxycarbonylamino-2-hydroxy-3-phenylpropionate according to claim 13, characterized by a PXRD diagram exhibiting characteristic lines located at 4.3, 6.8, 7.4, 8.6, 10.1, 11.1, 11.9, 12.2, 12.6 and 13.3±0.2 degrees 2-theta.
15. Dihydrate form C of 4-acetoxy-2a-benzoyloxy-5b,20-epoxy-1-hydroxy-7β,10β-dimethoxy-9-oxotax-11-en-13a-yl (2R,3S)-3-tert-butoxycarbonylamino-2-hydroxy-3-phenylpropionate according to claim 13, characterized by a PXRD diagram exhibiting characteristic lines located at 4.2, 6.9, 7.5, 8.4, 9.9, 10.9, 11.7, 12.3, 12.6 and 13.2±0.2 degrees 2-theta.
16. Method for preparing the anhydrous form B according to claim 3, which consists in heating the acetone solvate form A between 100 and 110° C. under vacuum or nitrogen sweeping, preferably for at least 9 hours, and then returning to ambient temperature.
17. Method for preparing the anhydrous form C according to claim 4, by maturation of the acetone solvate form A, or of the anhydrous form B, in water, followed by drying up to approximately 50° C. and then maintaining at ambient temperature at a relative humidity of less than 5%.
18. Method for preparing the anhydrous form D according to claim 5, by maturation, at ambient temperature, of the acetone solvate form A in ethanol and drying under nitrogen or under vacuum.
19. Method for preparing the anhydrous form D according to claim 5, by crystallization, at ambient temperature, of the acetone solvate form A from an oil, followed by rinsing with an alkane.
20. Method for preparing the anhydrous form D according to claim 5, by crystallization of a solution of 4-acetoxy-2a-benzoyloxy-5b,20-epoxy-1-hydroxy-7β,10β-dimethoxy-9-oxotax-11-en-13a-yl (2R,3S)-3-tert-butoxycarbonylamino-2-hydroxy-3-phenylpropionate in a mixture of Polysorbate 80, pH 3.5, ethanol and water (preferably, a 25/25/50 mixture) for approximately 48 hours at ambient temperature.
21. Method for preparing the anhydrous form E according to claim 6, by maturation of the acetone solvate form A in ethanol so as to intermediately form an ethanolic form which is subsequently desolvated under nitrogen sweeping or by heating at approximately 100° C. for 2 hours and then returning to ambient temperature.
22. Method for preparing the anhydrous form F according to claim 7, by desolvating the ethanol/water heterosolvate at 120° C. under a nitrogen atmosphere for 24 hours and then maintaining at a relative humidity of 0% at ambient temperature.
US16/188,687 2008-01-17 2018-11-13 Crystalline forms of dimethoxy docetaxel and methods for preparing the same Abandoned US20190144406A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US16/188,687 US20190144406A1 (en) 2008-01-17 2018-11-13 Crystalline forms of dimethoxy docetaxel and methods for preparing the same

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
FR0800243 2008-01-17
FR0800243A FR2926551A1 (en) 2008-01-17 2008-01-17 CRYSTALLINE FORMS OF DIMETHOXY DOCETAXEL AND METHODS FOR PREPARING SAME
PCT/FR2009/000042 WO2009115655A2 (en) 2008-01-17 2009-01-15 Crystalline forms of dimethoxy docetaxel and methods for preparing same
US12/837,559 US8378128B2 (en) 2008-01-17 2010-07-16 Crystalline forms of dimethoxy docetaxel and methods for preparing the same
US13/767,966 US8846959B2 (en) 2008-01-17 2013-02-15 Crystalline forms of dimethoxy docetaxel and methods for preparing the same
US14/453,087 US20140350272A1 (en) 2008-01-17 2014-08-06 Crystalline forms of dimethoxy docetaxel and methods for preparing the same
US15/646,375 US10160739B2 (en) 2008-01-17 2017-07-11 Crystalline forms of dimethoxy docetaxel and methods for preparing the same
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