US20160296458A1 - Tri-tightening skin care formulation and related methods - Google Patents
Tri-tightening skin care formulation and related methods Download PDFInfo
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- US20160296458A1 US20160296458A1 US14/999,665 US201614999665A US2016296458A1 US 20160296458 A1 US20160296458 A1 US 20160296458A1 US 201614999665 A US201614999665 A US 201614999665A US 2016296458 A1 US2016296458 A1 US 2016296458A1
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- alpha hydroxyl
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- 239000000203 mixture Substances 0.000 title claims abstract description 51
- 238000009472 formulation Methods 0.000 title claims abstract description 30
- 238000000034 method Methods 0.000 title claims abstract description 28
- 229920001477 hydrophilic polymer Polymers 0.000 claims abstract description 24
- 239000002253 acid Substances 0.000 claims abstract description 20
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract description 20
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 17
- 230000008569 process Effects 0.000 claims abstract description 15
- 238000004519 manufacturing process Methods 0.000 claims abstract description 3
- 108010020346 Polyglutamic Acid Proteins 0.000 claims description 26
- 229920002643 polyglutamic acid Polymers 0.000 claims description 26
- OVRNDRQMDRJTHS-UHFFFAOYSA-N N-acelyl-D-glucosamine Natural products CC(=O)NC1C(O)OC(CO)C(O)C1O OVRNDRQMDRJTHS-UHFFFAOYSA-N 0.000 claims description 14
- OVRNDRQMDRJTHS-FMDGEEDCSA-N N-acetyl-beta-D-glucosamine Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O OVRNDRQMDRJTHS-FMDGEEDCSA-N 0.000 claims description 14
- 229950006780 n-acetylglucosamine Drugs 0.000 claims description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 14
- MBLBDJOUHNCFQT-LXGUWJNJSA-N N-acetylglucosamine Natural products CC(=O)N[C@@H](C=O)[C@@H](O)[C@H](O)[C@H](O)CO MBLBDJOUHNCFQT-LXGUWJNJSA-N 0.000 claims description 12
- QBYIENPQHBMVBV-HFEGYEGKSA-N (2R)-2-hydroxy-2-phenylacetic acid Chemical compound O[C@@H](C(O)=O)c1ccccc1.O[C@@H](C(O)=O)c1ccccc1 QBYIENPQHBMVBV-HFEGYEGKSA-N 0.000 claims description 11
- IWYDHOAUDWTVEP-UHFFFAOYSA-N R-2-phenyl-2-hydroxyacetic acid Natural products OC(=O)C(O)C1=CC=CC=C1 IWYDHOAUDWTVEP-UHFFFAOYSA-N 0.000 claims description 11
- 239000004615 ingredient Substances 0.000 claims description 11
- 229960002510 mandelic acid Drugs 0.000 claims description 11
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 10
- 239000002537 cosmetic Substances 0.000 claims description 10
- 239000003814 drug Substances 0.000 claims description 10
- 229920002674 hyaluronan Polymers 0.000 claims description 10
- 239000002417 nutraceutical Substances 0.000 claims description 10
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims description 9
- 229960003160 hyaluronic acid Drugs 0.000 claims description 9
- 239000012190 activator Substances 0.000 claims description 5
- 239000003086 colorant Substances 0.000 claims description 5
- 239000000796 flavoring agent Substances 0.000 claims description 5
- 235000011187 glycerol Nutrition 0.000 claims description 5
- 150000002334 glycols Chemical class 0.000 claims description 5
- 229920005862 polyol Polymers 0.000 claims description 5
- 150000003077 polyols Chemical class 0.000 claims description 5
- 239000003755 preservative agent Substances 0.000 claims description 5
- 238000004132 cross linking Methods 0.000 claims description 4
- CBOJBBMQJBVCMW-BTVCFUMJSA-N (2r,3r,4s,5r)-2-amino-3,4,5,6-tetrahydroxyhexanal;hydrochloride Chemical compound Cl.O=C[C@H](N)[C@@H](O)[C@H](O)[C@H](O)CO CBOJBBMQJBVCMW-BTVCFUMJSA-N 0.000 claims description 3
- MSWZFWKMSRAUBD-IVMDWMLBSA-N 2-amino-2-deoxy-D-glucopyranose Chemical compound N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O MSWZFWKMSRAUBD-IVMDWMLBSA-N 0.000 claims description 3
- MSWZFWKMSRAUBD-UHFFFAOYSA-N beta-D-galactosamine Natural products NC1C(O)OC(CO)C(O)C1O MSWZFWKMSRAUBD-UHFFFAOYSA-N 0.000 claims description 3
- 229960002442 glucosamine Drugs 0.000 claims description 3
- 229960001911 glucosamine hydrochloride Drugs 0.000 claims description 3
- 229920000747 poly(lactic acid) Polymers 0.000 claims description 3
- 239000004626 polylactic acid Substances 0.000 claims description 3
- 210000003491 skin Anatomy 0.000 description 26
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 6
- 229920000642 polymer Polymers 0.000 description 3
- 230000009471 action Effects 0.000 description 2
- 238000013019 agitation Methods 0.000 description 2
- 229940061720 alpha hydroxy acid Drugs 0.000 description 2
- 150000001280 alpha hydroxy acids Chemical class 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000001509 sodium citrate Substances 0.000 description 2
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 2
- 210000000434 stratum corneum Anatomy 0.000 description 2
- 230000037303 wrinkles Effects 0.000 description 2
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 229920000954 Polyglycolide Polymers 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 238000009499 grossing Methods 0.000 description 1
- 230000000887 hydrating effect Effects 0.000 description 1
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical class CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 230000005923 long-lasting effect Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 235000010409 propane-1,2-diol alginate Nutrition 0.000 description 1
- 210000004927 skin cell Anatomy 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/88—Polyamides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/368—Carboxylic acids; Salts or anhydrides thereof with carboxyl groups directly bound to carbon atoms of aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/606—Nucleosides; Nucleotides; Nucleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/85—Polyesters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q1/00—Make-up preparations; Body powders; Preparations for removing make-up
- A61Q1/02—Preparations containing skin colorants, e.g. pigments
Definitions
- the present invention relates a skin care formulation and related method of manufacture.
- the present invention provides for a skin care formulation with a tri-tightening complex including a hydrophilic polymer, a desquamatory agent and an alpha hydroxyl acid.
- the present invention provides for a skin care formulation with a tri-tightening complex.
- the present invention provides for a formulation comprising: at least one hydrophilic polymer, at least one desquamatory agent and alpha hydroxyl acid.
- the hydrophilic polymer is selected from a group consisting essentially of polyglutamic acid (PGA), crosslinked polyglutamic acid, crosslinked hyaluronic acid, cross-linked poly lactic acid, and combination and mixtures thereof.
- PGA polyglutamic acid
- crosslinked polyglutamic acid crosslinked hyaluronic acid
- cross-linked poly lactic acid and combination and mixtures thereof.
- the desquamatory agent is selected from a group consisting essentially of N-acetyl glucosamine (NAG), glucosamine, glucosamine hydrochloride and combination and mixtures thereof.
- the alpha hydroxyl acid is mandelic acid.
- the formulation further comprises water.
- the formulation can be used as a product selected from a group consisting of skin care products, cosmetics, cosmeceuticals, pharmaceuticals and nutriceuticals.
- the formulation can be combined with other components and ingredients to form a product selected from a group consisting of skin care products, cosmetics, cosmeceuticals, pharmaceuticals and nutriceuticals.
- the formulation further comprises an activator selected from a group consisting essentially of Water, Glycerin, Glycols, Polyols, Polyglutamic Acid, Hyaluronic Acid, and combination and mixtures thereof.
- the formulation further comprises preservatives, flavoring and coloring agents.
- the hydrophilic polymer has increased molecular weight. In yet another further embodiment, the hydrophilic polymer is cross-linked. In still another further embodiment, the alpha hydroxyl acid has increased molecular weight.
- the present invention relates to a composition
- a composition comprising polyglutamic acid, mandelic acid and N-acetyl glucosamine.
- the polyglutamic acid has increased molecular weight.
- the polyglutamic acid is cross-linked.
- the alpha hydroxyl acid has increased molecular weight.
- the composition further comprises water.
- the composition can be used as a product selected from a group consisting of skin care products, cosmetics, cosmeceuticals, pharmaceuticals and nutriceuticals.
- the composition can be combined with other components and ingredients to form a product selected from a group consisting of skin care products, cosmetics, cosmeceuticals, pharmaceuticals and nutriceuticals.
- the composition further comprises an activator selected from a group consisting essentially of Water, Glycerin, Glycols, Polyols, Polyglutamic Acid, Hyaluronic Acid, and combination and mixtures thereof.
- composition further comprises preservatives, flavoring and coloring agents.
- the formulation manufactured by a process comprising: providing at least one hydrophilic polymer, at least one desquamatory agent and alpha hydroxyl acid; increasing the molecular weight of the hydrophilic polymer; crosslinking the hydrophilic polymer; increasing the molecular weight of the alpha hydroxyl acid; and admixing the hydrophilic polymer, the desquamatory agent and the alpha hydroxyl acid to make a formulation.
- the process further comprises admixing water.
- the hydrophilic polymer is from about 0.05% to about 0.3%
- said desquamatory agent is from about 0.05% to about 40%
- said alpha hydroxyl acid is from about 0.05% to about 30% of the formulation.
- the formulation can be used as a product selected from a group consisting of skin care products, cosmetics, cosmeceuticals, pharmaceuticals and nutriceuticals.
- the formulation is designed to be combined with other components and ingredients to form a product selected from a group consisting of skin care products, cosmetics, cosmeceuticals, pharmaceuticals and nutriceuticals.
- the process further comprises admixing at least one activator selected from a group consisting essentially of Water, Glycerin, Glycols, Polyols, Polyglutamic Acid, Hyaluronic Acid, and combination and mixtures thereof.
- the process further comprises admixing preservatives, flavoring and coloring agents.
- the present invention uses Polyglutamic acid (PGA) as the hydrophilic polymer.
- PGA Polyglutamic acid
- PGA has been used as a long term skin hydrating, plumping material. The material helps bind water to the skin, plumping the stratum corneum, adding to skin firming and reducing lines and wrinkles.
- the present invention may use Mandelic Acid which is a large molecular weight alpha hydroxy acid.
- Mandelic acid contains an aromatic ring that makes it slow to penetrate the upper layers of the stratum corneum. This helps to have a much more prolonged effect on the skin than other alpha hydroxy acids like glycolic or lactic acids.
- the skin resurfacing action of mandelic acid has numerous benefits: firstly, it has been shown to clip off dead surface skin cells, and secondly, makes the action of PGA better by giving it a smooth undisturbed surface to bind moisture to.
- mandelic acid contributes to the skin firming and smoothing benefits of the skin care formulations of the present invention.
- the desquamatory agent may be N-acetyl glucosamine (NAG).
- NAG N-acetyl glucosamine
- NAG has shown to give excellent results in skin smoothness, firming and reducing lines and wrinkles. It acts as a natural skin desquamatory, gently clipping off skin surface cells that are remaining on the surface too long. There also appears to be a retinoid-like effect of increasing collagen synthesis and improving dermal thickening. NAG assist in making the skin denser and less lined and wrinkled. The addition of NAG to mandelic acid and cross-linked PGA, appears to yield an optimum amount of skin firming that is recognizable on test subjects in two to four weeks.
- Phase A is weighed in a kettle equipped with high speed agitation. Phase B is then added to Phase A and mixed until homogenous.
- the ingredients and percentage of each ingredient in the composition is set forth in Table 1 below:
- Phase A is weighed in a kettle equipped with high speed agitation.
- the ingredients and percentage of each ingredient in the composition is set forth in Table 2 below:
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Dermatology (AREA)
- Emergency Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Cosmetics (AREA)
- Inorganic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
Abstract
The present invention provides for a method or process for manufacturing a formulation comprising: admixing at least one hydrophilic polymer, at least one desquamatory agent and alpha hydroxyl acid.
Description
- This application is a divisional of U.S. patent application Ser. No. 13/998,617 filed on Nov. 18, 2013 entitled “Tri-tightening Skin Care Formulation”.
- 1. Field of Invention
- The present invention relates a skin care formulation and related method of manufacture. In particular, the present invention provides for a skin care formulation with a tri-tightening complex including a hydrophilic polymer, a desquamatory agent and an alpha hydroxyl acid.
- 2. Description of Related Art
- There are numerous prior art patents that disclose skin tightening properties. The present invention provides for a skin care formulation with a tri-tightening complex.
- In one embodiment, the present invention provides for a formulation comprising: at least one hydrophilic polymer, at least one desquamatory agent and alpha hydroxyl acid.
- In another embodiment, the hydrophilic polymer is selected from a group consisting essentially of polyglutamic acid (PGA), crosslinked polyglutamic acid, crosslinked hyaluronic acid, cross-linked poly lactic acid, and combination and mixtures thereof.
- In yet another embodiment, the desquamatory agent is selected from a group consisting essentially of N-acetyl glucosamine (NAG), glucosamine, glucosamine hydrochloride and combination and mixtures thereof.
- In still another embodiment, the alpha hydroxyl acid is mandelic acid.
- In still yet another embodiment, the formulation further comprises water. In a further embodiment, the formulation can be used as a product selected from a group consisting of skin care products, cosmetics, cosmeceuticals, pharmaceuticals and nutriceuticals. In another further embodiment, the formulation can be combined with other components and ingredients to form a product selected from a group consisting of skin care products, cosmetics, cosmeceuticals, pharmaceuticals and nutriceuticals.
- In yet a further embodiment, the formulation further comprises an activator selected from a group consisting essentially of Water, Glycerin, Glycols, Polyols, Polyglutamic Acid, Hyaluronic Acid, and combination and mixtures thereof. In still a further embodiment, the formulation further comprises preservatives, flavoring and coloring agents.
- In still yet a further embodiment, the hydrophilic polymer has increased molecular weight. In yet another further embodiment, the hydrophilic polymer is cross-linked. In still another further embodiment, the alpha hydroxyl acid has increased molecular weight.
- In still yet another embodiment, the present invention relates to a composition comprising polyglutamic acid, mandelic acid and N-acetyl glucosamine. In another embodiment, the polyglutamic acid has increased molecular weight. In yet another embodiment, the polyglutamic acid is cross-linked. In still another embodiment, the alpha hydroxyl acid has increased molecular weight.
- In still yet another embodiment, the composition further comprises water. In a further embodiment, the composition can be used as a product selected from a group consisting of skin care products, cosmetics, cosmeceuticals, pharmaceuticals and nutriceuticals. In another further embodiment, the composition can be combined with other components and ingredients to form a product selected from a group consisting of skin care products, cosmetics, cosmeceuticals, pharmaceuticals and nutriceuticals.
- In yet a further embodiment, the composition further comprises an activator selected from a group consisting essentially of Water, Glycerin, Glycols, Polyols, Polyglutamic Acid, Hyaluronic Acid, and combination and mixtures thereof.
- In still a further embodiment, the composition further comprises preservatives, flavoring and coloring agents.
- In still yet a further embodiment, the formulation manufactured by a process comprising: providing at least one hydrophilic polymer, at least one desquamatory agent and alpha hydroxyl acid; increasing the molecular weight of the hydrophilic polymer; crosslinking the hydrophilic polymer; increasing the molecular weight of the alpha hydroxyl acid; and admixing the hydrophilic polymer, the desquamatory agent and the alpha hydroxyl acid to make a formulation.
- In another embodiment, the process further comprises admixing water.
- In another further embodiment, the hydrophilic polymer is from about 0.05% to about 0.3%, said desquamatory agent is from about 0.05% to about 40% and said alpha hydroxyl acid is from about 0.05% to about 30% of the formulation.
- In yet another further embodiment, the formulation can be used as a product selected from a group consisting of skin care products, cosmetics, cosmeceuticals, pharmaceuticals and nutriceuticals.
- In still another embodiment, the formulation is designed to be combined with other components and ingredients to form a product selected from a group consisting of skin care products, cosmetics, cosmeceuticals, pharmaceuticals and nutriceuticals.
- In still yet another embodiment, the process further comprises admixing at least one activator selected from a group consisting essentially of Water, Glycerin, Glycols, Polyols, Polyglutamic Acid, Hyaluronic Acid, and combination and mixtures thereof.
- In a further embodiment, the process further comprises admixing preservatives, flavoring and coloring agents.
- As required, detailed embodiments of the present invention are disclosed herein; it is to be understood that the disclosed embodiments are merely exemplary of the invention that may be embodied in various forms. Therefore, specific structural and functional details disclosed herein are not to be interpreted as limits, but merely as a basis for teaching one skilled in the art to employ the present invention. The specific examples below will enable the invention to be better understood. However, they are given merely by way of guidance and do not imply any limitation.
- In one embodiment, the present invention uses Polyglutamic acid (PGA) as the hydrophilic polymer. PGA has been used as a long term skin hydrating, plumping material. The material helps bind water to the skin, plumping the stratum corneum, adding to skin firming and reducing lines and wrinkles.
- These polymers have usually been in the one to two thousand Dalton ranges with the maximum molecular weight of 10,000 Daltons. Recently, breakthroughs in biotechnology have produced polymers in the 2 to 3 million Dalton range. These high molecular weight PGAs retain much more water on the skin than the lower molecular weight ones. They actually hold more moisture than the Industry standard, hyaluronic acids, that have molecular weights in the 2 million Dalton range. In addition, a special grade of PGA was employed in this invention. A PGA with a molecular weight of about 2 million Daltons, that is additionally cross-linked. This cross-linking helps render the polymer to be more long lasting on the skin surface. It makes it less sensitive to degradation by skin enzymes and other agents. The high molecular weight cross-linked PGA provides a longer lasting firming and plumping effect than that of other PGA's and hyaluronic acid.
- In yet another embodiment, the present invention may use Mandelic Acid which is a large molecular weight alpha hydroxy acid. Mandelic acid contains an aromatic ring that makes it slow to penetrate the upper layers of the stratum corneum. This helps to have a much more prolonged effect on the skin than other alpha hydroxy acids like glycolic or lactic acids. The skin resurfacing action of mandelic acid has numerous benefits: firstly, it has been shown to clip off dead surface skin cells, and secondly, makes the action of PGA better by giving it a smooth undisturbed surface to bind moisture to. Thusly, mandelic acid contributes to the skin firming and smoothing benefits of the skin care formulations of the present invention.
- In still another embodiment, the desquamatory agent may be N-acetyl glucosamine (NAG). NAG has shown to give excellent results in skin smoothness, firming and reducing lines and wrinkles. It acts as a natural skin desquamatory, gently clipping off skin surface cells that are remaining on the surface too long. There also appears to be a retinoid-like effect of increasing collagen synthesis and improving dermal thickening. NAG assist in making the skin denser and less lined and wrinkled. The addition of NAG to mandelic acid and cross-linked PGA, appears to yield an optimum amount of skin firming that is recognizable on test subjects in two to four weeks.
- The following examples are set forth below:
- Phase A is weighed in a kettle equipped with high speed agitation. Phase B is then added to Phase A and mixed until homogenous. The ingredients and percentage of each ingredient in the composition is set forth in Table 1 below:
-
TABLE 1 Phase: Ingredients: Percentage: A Water 58.100 Mega Moist 0.500 N-Acetyl D-Glucosamine 4.000 Mandelic Acid 0.500 Ritaloe 1X 1.000 Citric Acid 0.100 Sodium Citrate 0.300 B Alcohol 35.000 Phenoyxethanol 0.500 Total Percentage: 100.000 - Phase A is weighed in a kettle equipped with high speed agitation. The ingredients and percentage of each ingredient in the composition is set forth in Table 2 below:
-
TABLE 2 Phase: Ingredients: Percentage: A Water 93.100 Mega Moist 0.500 N-Acetyl D-Glucosamine 4.000 Mandelic Acid 0.500 Ritaloe 1X 1.000 Citric Acid 0.100 Sodium Citrate 0.300 Phenoyxethanol 0.500 Total Percentage: 100.00 - The present invention is not limited to the above Examples and Tables. Numerous modifications and variations of the present invention are possible in light of the above teachings. It is therefore to be understood that within the scope of the attendant claims attached hereto, this invention may be practiced other than as specifically disclosed herein.
Claims (20)
1. A formulation manufactured by a process comprising:
providing at least one hydrophilic polymer, at least one desquamatory agent and alpha hydroxyl acid;
increasing the molecular weight of said hydrophilic polymer;
crosslinking said hydrophilic polymer;
increasing the molecular weight of said alpha hydroxyl acid; and
admixing said hydrophilic polymer, said desquamatory agent and said alpha hydroxyl acid to make a formulation.
2. The process of claim 1 further comprising admixing water.
3. The process of claim 1 wherein said hydrophilic polymer is selected from a group consisting essentially of polyglutamic acid (PGA), crosslinked polyglutamic acid, crosslinked hyaluronic acid, cross-linked poly lactic acid, and combination and mixtures thereof.
4. The process of claim 1 wherein said desquamatory agent is selected from a group consisting essentially of N-acetyl glucosamine (NAG), glucosamine, glucosamine hydrochloride and combination and mixtures thereof.
5. The process of claim 1 wherein said alpha hydroxyl acid is selected from a group consisting essentially of mandelic acid, and combination and mixtures thereof.
6. The process of claim 1 wherein said hydrophilic polymer is from about 0.05% to about 0.3%, said desquamatory agent is from about 0.05% to about 40% and said alpha hydroxyl acid is from about 0.05% to about 30% of the formulation.
7. The process of claim 1 wherein said formulation can be used as a product selected from a group consisting of skin care products, cosmetics, cosmeceuticals, pharmaceuticals and nutriceuticals.
8. The process of claim 1 wherein said formulation is designed to be combined with other components and ingredients to form a product selected from a group consisting of skin care products, cosmetics, cosmeceuticals, pharmaceuticals and nutriceuticals.
9. The process of claim 1 further comprising admixing at least one activator selected from a group consisting essentially of Water, Glycerin, Glycols, Polyols, Polyglutamic Acid, Hyaluronic Acid, and combination and mixtures thereof.
10. The process of claim 1 further comprising admixing preservatives, flavoring and coloring agents.
11. A method of manufacturing a formulation, said method comprising:
providing at least one hydrophilic polymer, at least one desquamatory agent and alpha hydroxyl acid;
increasing the molecular weight of said hydrophilic polymer;
crosslinking said hydrophilic polymer;
increasing the molecular weight of said alpha hydroxyl acid; and
admixing said hydrophilic polymer, said desquamatory agent and said alpha hydroxyl acid to make a formulation.
12. The method of claim 11 further comprising admixing water.
13. The method of claim 11 wherein said hydrophilic polymer is selected from a group consisting essentially of polyglutamic acid (PGA), crosslinked polyglutamic acid, crosslinked hyaluronic acid, cross-linked poly lactic acid, and combination and mixtures thereof.
14. The method of claim 11 wherein said desquamatory agent is selected from a group consisting essentially of N-acetyl glucosamine (NAG), glucosamine, glucosamine hydrochloride and combination and mixtures thereof.
15. The method of claim 11 wherein said alpha hydroxyl acid is selected from a group consisting essentially of mandelic acid, and combination and mixtures thereof.
16. The method of claim 11 wherein said hydrophilic polymer is from about 0.05% to about 0.3%, said desquamatory agent is from about 0.05% to about 40% and said alpha hydroxyl acid is from about 0.05% to about 30% of the formulation.
17. The method of claim 11 wherein said formulation can be used as a product selected from a group consisting of skin care products, cosmetics, cosmeceuticals, pharmaceuticals and nutriceuticals.
18. The method of claim 11 wherein said formulation is designed to be combined with other components and ingredients to form a product selected from a group consisting of skin care products, cosmetics, cosmeceuticals, pharmaceuticals and nutriceuticals.
19. The method of claim 11 further comprising admixing at least one activator selected from a group consisting essentially of Water, Glycerin, Glycols, Polyols, Polyglutamic Acid, Hyaluronic Acid, and combination and mixtures thereof.
20. The method of claim 11 further comprising admixing preservatives, flavoring and coloring agents.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14/999,665 US20160296458A1 (en) | 2013-11-18 | 2016-06-10 | Tri-tightening skin care formulation and related methods |
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| Application Number | Priority Date | Filing Date | Title |
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| US13/998,617 US9474708B2 (en) | 2013-11-18 | 2013-11-18 | Tritightening skin care formulation |
| US14/999,665 US20160296458A1 (en) | 2013-11-18 | 2016-06-10 | Tri-tightening skin care formulation and related methods |
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| US13/998,617 Division US9474708B2 (en) | 2013-11-18 | 2013-11-18 | Tritightening skin care formulation |
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| US14/999,665 Abandoned US20160296458A1 (en) | 2013-11-18 | 2016-06-10 | Tri-tightening skin care formulation and related methods |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040092482A1 (en) * | 2002-11-07 | 2004-05-13 | Gupta Shyam K. | Hydroxy acids based delivery systems for skin resurfacing and anti-aging compositions |
| US20060153785A1 (en) * | 2005-01-12 | 2006-07-13 | Guan-Huei Ho | Moisturizers comprising one or more of gamma-polyglutamic acid (gamma-PGA, H form), gamma-polyglutamates and gamma-polyglutamate hydrogels for use in cosmetic or personal care products |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5385938B1 (en) * | 1986-12-23 | 1997-07-15 | Tristrata Inc | Method of using glycolic acid for treating wrinkles |
| WO2002072040A1 (en) * | 2001-03-13 | 2002-09-19 | Ajinomoto Co., Inc. | Comsetics or external preparaiotns for skin |
| ITMI20051658A1 (en) * | 2005-09-08 | 2007-03-09 | Solvay Solexis Spa | COSMETIC COMPOSITIONS |
| WO2008110672A1 (en) * | 2007-03-12 | 2008-09-18 | L'oreal | Use of a c-glycoside derivative as an anti-oxidant agent |
-
2013
- 2013-11-18 US US13/998,617 patent/US9474708B2/en not_active Expired - Fee Related
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- 2016-06-10 US US14/999,665 patent/US20160296458A1/en not_active Abandoned
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040092482A1 (en) * | 2002-11-07 | 2004-05-13 | Gupta Shyam K. | Hydroxy acids based delivery systems for skin resurfacing and anti-aging compositions |
| US20060153785A1 (en) * | 2005-01-12 | 2006-07-13 | Guan-Huei Ho | Moisturizers comprising one or more of gamma-polyglutamic acid (gamma-PGA, H form), gamma-polyglutamates and gamma-polyglutamate hydrogels for use in cosmetic or personal care products |
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| US9474708B2 (en) | 2016-10-25 |
| US20160008259A1 (en) | 2016-01-14 |
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