US20130119072A1

US20130119072A1 - Temperature-stabilized storage containers for medicinals

Info

Publication number: US20130119072A1
Application number: US13/720,328
Authority: US
Inventors: Roderick A. Hyde; Edward K.Y. Jung; Nathan P. Myhrvold; Clarence T. Tegreene; William H. Gates, III; Charles Whitmer; Lowell L. Wood, JR.
Original assignee: Tokitae LLC
Current assignee: Tokitae LLC
Priority date: 2007-12-11
Filing date: 2012-12-19
Publication date: 2013-05-16
Also published as: US8377030B2; US20130119071A1; US20090145911A1

Abstract

Systems include integrally sealed medicinal storage containers, including one or more segments of an ultra efficient insulation material, the one or more segments having one or more surface regions, the one or more segments principally defining at least one storage region, and one or more regions of substantially thermally sealed connections between at least one of the one or more surface regions of the one or more segments wherein the one or more regions of substantially thermally sealed connections and the one or more segments form an integrally thermally sealed medicinal storage region.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS

The present application is related to and claims the benefit of the earliest available effective filing date(s) from the following listed application(s) (the “Related Applications”) (e.g., claims earliest available priority dates for other than provisional patent applications or claims benefits under 35 USC §119(e) for provisional patent applications, for any and all parent, grandparent, great-grandparent, etc. applications of the Related Application(s)).

RELATED APPLICATIONS

- For purposes of the USPTO extra-statutory requirements, the present application constitutes a continuation-in-part of U.S. patent application Ser. No. 12/001,757, entitled TEMPERATURE-STABILIZED STORAGE CONTAINERS, naming Roderick A. Hyde; Edward K. Y. Jung; Nathan P. Myhrvold; Clarence T. Tegreene; William H. Gates, III; Charles Whitmer; and Lowell L. Wood, Jr. as inventors, filed Dec. 11, 2007, which is currently co-pending, or is an application of which a currently co-pending application is entitled to the benefit of the filing date.
- For purposes of the USPTO extra-statutory requirements, the present application constitutes a continuation-in-part of U.S. patent application Ser. No. [To Be Assigned], entitled TEMPERATURE-STABILIZED STORAGE SYSTEMS, naming Roderick A. Hyde; Edward K. Y. Jung; Nathan P. Myhrvold; Clarence T. Tegreene; William H. Gates, III; Charles Whitmer; and Lowell L. Wood, Jr. as inventors, filed Dec. 27, 2007, which is currently co-pending, or is an application of which a currently co-pending application is entitled to the benefit of the filing date.
- For purposes of the USPTO extra-statutory requirements, the present application constitutes a continuation-in-part of U.S. patent application Ser. No. [To Be Assigned], entitled TEMPERATURE-STABILIZED STORAGE CONTAINERS WITH DIRECTED ACCESS, naming Roderick A. Hyde; Edward K. Y. Jung; Nathan P. Myhrvold; Clarence T. Tegreene; William H. Gates, III; Charles Whitmer; and Lowell L. Wood, Jr. as inventors, filed Dec. 27, 2007, which is currently co-pending, or is an application of which a currently co-pending application is entitled to the benefit of the filing date.

The United States Patent Office (USPTO) has published a notice to the effect that the USPTO's computer programs require that patent applicants reference both a serial number and indicate whether an application is a continuation or continuation-in-part. Stephen G. Kunin, Benefit of Prior-Filed Application, USPTO Official Gazette Mar. 18, 2003, available at http://www.uspto.gov/web/offices/com/sol/og/2003/week11/patbene.htm. The present Applicant Entity (hereinafter “Applicant”) has provided above a specific reference to the application(s) from which priority is being claimed as recited by statute. Applicant understands that the statute is unambiguous in its specific reference language and does not require either a serial number or any characterization, such as “continuation” or “continuation-in-part,” for claiming priority to U.S. patent applications. Notwithstanding the foregoing, Applicant understands that the USPTO's computer programs have certain data entry requirements, and hence Applicant is designating the present application as a continuation-in-part of its parent applications as set forth above, but expressly points out that such designations are not to be construed in any way as any type of commentary and/or admission as to whether or not the present application contains any new matter in addition to the matter of its parent application(s).
All subject matter of the Related Applications and of any and all parent, grandparent, great-grandparent, etc. applications of the Related Applications is incorporated herein by reference to the extent such subject matter is not inconsistent herewith.

SUMMARY

Systems include at least one integrally thermally sealed container, including one or more segments of a ultra efficient insulation material, the one or more segments having one or more surface regions, the one or more segments principally defining at least one medicinal storage region; and one or more regions of substantially thermally sealed connections between at least one of the one or more surface regions of the one or more segments wherein the one or more regions of substantially thermally sealed connections and the one or more segments form an integrally thermally sealed medicinal storage region. In addition to the foregoing, other aspects are described in the claims, drawings and text forming a part of the present disclosure.
Some aspects include a medicinal storage container, including a storage assembly including one or more sections of ultra efficient insulation material substantially defining at least one substantially thermally sealed medicinal storage region, and an interlock assembly including one or more interlocks arranged to provide controllable egress of a quantity of a material from the substantially thermally sealed medicinal storage region. In addition to the foregoing, other aspects are described in the claims, drawings and text forming a part of the present disclosure.
Some aspects include a medicinal storage container including at least one medicinal storage structure, including one or more segments of ultra efficient insulation material shaped to define at least one substantially temperature-stabilized medicinal storage region, and at least one access region including at least one region of the one or more segments of an ultra efficient insulation material configured for at least one perforation by at least one perforation device, wherein one or more of the at least one perforation is configured to provide for a controlled egress of a quantity of a medicinal material from the at least one substantially temperature-stabilized storage region. In addition to the foregoing, other aspects are described in the claims, drawings and text forming a part of the present disclosure.
The foregoing summary is illustrative only and is not intended to be in any way limiting. In addition to the illustrative aspects, embodiments, and features described above, further aspects, embodiments, and features will become apparent by reference to the drawings and the following detailed description.

BRIEF DESCRIPTION OF THE FIGURES

FIG. 1 is a schematic of some aspects of an ultra efficient insulation material.

FIG. 2A is a schematic of some aspects of an integrally thermally sealed medicinal storage container.

FIG. 2B is a schematic of some aspects of an integrally thermally sealed medicinal storage container.

FIG. 3 is a schematic of some aspects of an integrally thermally sealed medicinal storage container.

FIG. 4 is a schematic of some aspects of an integrally thermally sealed medicinal storage container.

FIG. 5 is a schematic of some aspects of an integrally thermally sealed medicinal storage container.

FIG. 6 is a schematic of some aspects of an integrally thermally sealed medicinal storage container.

FIG. 7 is a schematic of some aspects of a medicinal storage container.

FIG. 8A is a schematic of some aspects of a medicinal storage container.

FIG. 8B is a schematic of some aspects of a medicinal storage container.

FIG. 9 is a schematic of some aspects of a medicinal storage container.

FIG. 10A is a schematic of some aspects of a medicinal storage container.

FIG. 10B is a schematic of some aspects of a medicinal storage container.

FIG. 10C is a schematic of some aspects of a medicinal storage container.

FIG. 11 is a schematic of some aspects of a medicinal storage container.

FIG. 12 is a schematic of some aspects of a medicinal storage container.

FIG. 13 is a schematic of some aspects of a coupling mechanism for a medicinal storage container.

FIG. 14 is a schematic of some aspects of a medicinal storage container.

FIG. 15 is a schematic of some aspects of a medicinal storage container.

DETAILED DESCRIPTION

In the following detailed description, reference is made to the accompanying drawings, which form a part hereof. In the drawings, similar symbols typically identify similar components, unless context dictates otherwise. The illustrative embodiments described in the detailed description, drawings, and claims are not meant to be limiting. Other embodiments may be utilized, and other changes may be made, without departing from the spirit or scope of the subject matter presented here.
In some aspects, systems include at least one integrally thermally sealed medicinal storage container, including one or more segments of an ultra efficient insulation material, the one or more segments having one or more surface regions, the one or more segments principally defining at least one storage region; and one or more regions of substantially thermally sealed connections between at least one of the one or more surface regions of the one or more segments wherein the one or more regions of substantially thermally sealed connections and the one or more segments form an integrally thermally sealed medicinal storage region. An integrally thermally sealed medicinal storage container, such as the ones depicted in FIGS. 2A, 2B, 3, 4, 5 and 6, includes ultra efficient insulation material principally defining at least one substantially thermally sealed storage region. An integrally thermally sealed medicinal storage container, such as the ones depicted in FIGS. 2A, 2B, 3, 4, 5 and 6, includes at least one substantially thermally sealed storage region with extremely low heat conductance and extremely low heat radiation transfer between the outside environment of the container and the area internal to the at least one substantially thermally sealed medicinal storage region. An integrally sealed medicinal storage container may have virtually zero heat conductance and virtually zero heat radiation transfer between the outside environment of the container and the inside of the at least one substantially thermally sealed medicinal storage region. As used herein, “integrally sealed” refers to containers that are constituently sealed, for example a container that must be broken open to access the contents of the least one integrally thermally sealed medicinal storage region. In some embodiments, an integrally thermally sealed medicinal storage container may be refurbished or repaired and reused, while in other embodiments an integrally thermally sealed medicinal storage container may be designed for single-use and be disposable.
In some aspects, a medicinal storage container may include an outer assembly including one or more sections of ultra efficient insulation material substantially defining at least one substantially thermally sealed medicinal storage region, and an inner assembly including one or more interlocks configured to provide controllable egress of a quantity of a material from one or more of the at least one substantially thermally sealed medicinal storage region. A medicinal storage container such as the ones depicted in FIGS. 7, 8A, 8B, 9, 10A, 10B and 10C, may include containers wherein at least one of the one or more interlocks are mechanically operable interlocks. In some embodiments, interlocks may be configured to allow for controllable ingress of material into at least one medicinal storage region. For example, in some embodiments a medicinal storage container may be refurbished or repaired and reused, including the addition of medicinal units into at least one storage region. A medicinal storage container may, in some embodiments, be refurbished or repaired and reused in conjunction with the addition, removal or recharge of one or more heat sink units. A medicinal storage container may, in some embodiments, be refurbished or repaired and reused in conjunction with the addition or removal of one or more removable inserts within one or more of the at least one storage region.
In some aspects, a medicinal storage container includes at least one medicinal storage structure, including: one or more segments of an ultra efficient insulation material shaped to define at least one substantially temperature-stabilized medicinal storage region; and at least one access region, including: at least one region of the one or more segments of a an ultra efficient insulation material configured for at least one perforation by a perforation device, wherein one or more of the at least one perforation is configured to provide for a controlled egress of a quantity of a medicinal material from the at least one substantially temperature-stabilized medicinal storage region. A medicinal storage container, such as, for example, those depicted in FIGS. 11, 12, 13, 14 and 15, may include containers including an access region with at least one region of one or more segments of ultra efficient insulation material configured for at least one perforation by at least one perforation device. Some embodiments may include at least one thermally-insulated cover, including a sealing portion positioned for mating to the at least one access region. For example, a thermally-insulated cover may include ultra efficient insulation material. In some embodiments, a medicinal storage container including an access region may be single-use and disposable, while in other embodiments a medicinal storage container including an access region may be repaired or refurbished and reused. For example, a medicinal storage container including an access region may include an access region which is, in whole or in part, replaceable, repairable, may be refurbished, or which may be resealed after perforation by a perforation device. An access region may be resealed, for example, with a thermally-insulated sealable cover, which may be located externally to the container or internally to the container.
The term “medicinal”, as used herein, includes a drug, composition, formulation, material or compound intended for medicinal or therapeutic use. For example, a medicinal may include drugs, vaccines, therapeutics, vitamins, pharmaceuticals, remedies, homeopathic agents, naturopathic agents, or treatment modalities in any form, combination or configuration. For example, a medicinal may include vaccines, such as: a vaccine packaged as an oral dosage compound, vaccine within a prefilled syringe, a container or vial containing vaccine, vaccine within a unijet device, or vaccine within an externally deliverable unit (e.g. a vaccine patch for transdermal applications). For example, a medicinal may include treatment modalities, such as: antibody therapies, small-molecule compounds, anti-inflammatory agents, therapeutic drugs, vitamins, or pharmaceuticals in any form, combination or configuration. A medicinal may be in the form of a liquid, gel, solid, semi-solid, vapor, or gas. In some embodiments, a medicinal may be a composite. For example, a medicinal may include a bandage infused with antibiotics, anti-inflammatory agents, coagulants, neurotrophic agents, angiogenic agents, vitamins or pharmaceutical agents.
The term “ultra efficient insulation material,” as used herein, may include one or more type of insulation material with extremely low heat conductance and extremely low heat radiation transfer between the surfaces of the insulation material. The ultra efficient insulation material may include, for example, one or more layers of thermally reflective film, high vacuum, aerogel, low thermal conductivity bead-like units, disordered layered crystals, low density solids, or low density foam. In some embodiments, the ultra efficient insulation material includes one or more low density solids such as aerogels, such as those described in, for example: Fricke and Emmerling, Aerogels-preparation, properties, applications, Structure and Bonding 77: 37-87 (1992); and Pekala, Organic aerogels from the polycondensation of resorcinol with formaldehyde, Journal of Materials Science 24: 3221-3227 (1989); each of which are herein incorporated by reference. As used herein, “low density” may include materials with density from about 0.01 g/cm³to about 0.10 g/cm³, and materials with density from about 0.005 g/cm³to about 0.05 g/cm³. In some embodiments, the ultra efficient insulation material includes one or more layers of disordered layered crystals, such as those described in, for example: Chiritescu et al., Ultralow thermal conductivity in disordered, layered WSe₂crystals, Science 315: 351-353 (2007), which is herein incorporated by reference. In some embodiments, the ultra efficient insulation material includes at least two layers of thermal reflective film separated, for example, by at least one of: high vacuum, low thermal conductivity spacer units, low thermal conductivity bead like units, or low density foam. For example, the ultra-efficient insulation material may include at least one multiple layer insulating composite such as described in U.S. Pat. No. 6,485,805 to Smith et al., titled “Multilayer insulation composite,” which is herein incorporated by reference. For example, the ultra-efficient insulation material may include at least one metallic sheet insulation system, such as that described in U.S. Pat. No. 5,915,283 to Reed et al., titled “Metallic sheet insulation system,” which is herein incorporated by reference. For example, the ultra-efficient insulation material may include at least one thermal insulation system, such as that described in U.S. Pat. No. 6,967,051 to Augustynowicz et al., titled “Thermal insulation systems,” which is herein incorporated by reference. For example, the ultra-efficient insulation material may include at least one rigid multilayer material for thermal insulation, such as that described in U.S. Pat. No. 7,001,656 to Maignan et al., titled “Rigid multilayer material for thermal insulation,” which is herein incorporated by reference.
In reference now to FIG. 1, in some embodiments, an ultra efficient insulation material may include at least one multilayer insulation material. For example, an ultra efficient insulation material may include multilayer insulation material such as that used in space program launch vehicles, including by NASA. See, e.g., Daryabeigi, Thermal analysis and design optimization of multilayer insulation for reentry aerodynamic heating, Journal of Spacecraft and Rockets 39: 509-514 (2002), which is herein incorporated by reference. As illustrated in FIG. 1, in some embodiments, an ultra efficient insulation material may include at least two layers of thermal reflective film 120, 130 separated by low thermal conductivity spacer units 140. The low thermal conductivity spacer units may include, for example, low thermal conductivity bead-like structures, aerogel particles, folds or inserts of thermal reflective film. Although two layers of thermal reflective film are shown in FIG. 1, in some embodiments there may be one layer of thermal reflective film or more than two layers of thermal reflective film. Similarly, there may be variable numbers of low thermal conductivity spacer units 140. In some embodiments there may be one or more additional layers within or in addition to the ultra efficient insulation material, such as, for example, an outer structural layer 100 or an inner structural layer 110. An inner or an outer structural layer may be made of any material appropriate to the embodiment, for example an inner or an outer structural layer may include: plastic, metal, alloy, composite, or glass. In some embodiments, there may be one or more layers of high vacuum between layers of thermal reflective film.
Some embodiments may include at least one superinsulation material. For example, in some embodiments, an ultra efficient insulation material includes at least one material described above and at least one superinsulation material. As used herein, a “superinsulation material” may include structures wherein at least two floating thermal radiation shields exist in an evacuated double-wall annulus, closely spaced but thermally separated by at least one poor-conducting fiber-like material.
In some embodiments, an ultra efficient insulation material includes at least two layers of thermal reflective material separated from each other by magnetic suspension. The layers of thermal reflective material may be separated, for example, by magnetic suspension methods including magnetic induction suspension or ferromagnetic suspension. For more information regarding magnetic suspension systems, see Thompson, Eddy current magnetic levitation models and experiments, IEEE Potentials, February/March 2000, 40-44, and Post, Maglev: a new approach, Scientific American, January 2000, 82-87, which are each incorporated herein by reference. Ferromagnetic suspension may include, for example, the use of magnets with a Halbach field distribution. For more information regarding Halbach machine topologies and related applications suitable for use in an embodiment described herein, see Zhu and Howe, Halbach permanent magnet machines and applications: a review, IEE Proc.-Electr. Power Appl. 148: 299-308 (2001), which is herein incorporated by reference.
The term “heat sink unit,” as used herein, includes one or more units that absorb thermal energy, such as that described, for example, in U.S. Pat. No. 5,390,734 to Voorhes et al., titled “Heat Sink,” U.S. Pat. No. 4,057,101 to Ruka et al., titled “Heat Sink,” U.S. Pat. No. 4,003,426 to Best et al., titled “Heat or Thermal Energy Storage Structure,” and U.S. Pat. No. 4,976,308 to Faghri titled “Thermal Energy Storage Heat Exchanger,” which are each incorporated herein by reference. Heat sink units may include, for example: units containing frozen water or other types of ice; units including frozen material that is generally gaseous at ambient temperature and pressure, such as frozen carbon dioxide (CO₂); units including liquid material that is generally gaseous at ambient temperature and pressure, such as liquid nitrogen; units including artificial gels or composites with heat sink properties; units including phase change materials; and units including refrigerants, such as that described, for example, in: U.S. Pat. No. 5,261,241 to Kitahara et al., titled “Refrigerant,” U.S. Pat. No. 4,810,403 to Bivens et al., titled “Halocarbon Blends for Refrigerant Use,” U.S. Pat. No. 4,428,854 to Enjo et al., titled “Absorption Refrigerant Compositions for Use in Absorption Refrigeration Systems,” and U.S. Pat. No. 4,482,465 to Gray, titled “Hydrocarbon-Halocarbon Refrigerant Blends,” which are each herein incorporated by reference. Some embodiments of containers as described herein may include one or more heat sink units, or some may include no heat sink units. Heat sink units may be thermally coupled to one or more of the at least one storage region. Some embodiments may include one or more type of heat sink units. In some embodiments, heat sink units may be removable, for example they may be removed in conjunction with stored medicinal units or independently. In some embodiments, heat sink units may be replaceable or rechargeable, for example heat sink units containing frozen water or other types of ice or those containing units including artificial gels or composites with heat sink properties that may be refrozen.
The term “active cooling unit,” as used herein, includes conductive and radiative cooling mechanisms that require electricity from an external source to operate. For example, active cooling units may include one or more of: actively powered fans, actively pumped refrigerant systems, thermoelectric systems, active heat pump systems, active vapor-compression refrigeration systems and active heat exchanger systems. The external energy required to operate such mechanisms may originate, for example, from municipal electrical power supplies or electric batteries. Some embodiments of containers as described herein may include no active cooling units.
Some embodiments include at least one layer of nontoxic material on an interior surface of one or more of the at least one storage region. For example, FIG. 4 depicts nontoxic material 490 within storage region 430. Nontoxic material may include, for example, material that does not itself react with, or produce residue that may be toxic to, the contents of the at least one substantially thermally sealed storage region, or material that does not produce residue, or otherwise impart properties to the contents that may be toxic to, the future users of contents of the at least one substantially thermally sealed storage region. Nontoxic material may include material that maintains the chemical structure of the contents of the at least one substantially thermally sealed storage region, for example nontoxic material may include chemically inert or non-reactive materials. Nontoxic material may include material that has been developed for use in, for example, medical, pharmaceutical or food storage applications. Nontoxic material may include material that may be cleaned or sterilized, for example material that may be irradiated, autoclaved, or disinfected. Nontoxic material may include material that contains one or more antibacterial, antiviral, antimicrobial, or antipathogen agents. For example, nontoxic material may include aldehydes, hypochlorites, oxidizing agents, phenolics, quaternary ammonium compounds, or silver. Nontoxic material may include material that is structurally stable in the presence of one or more cleaning or sterilizing compounds or radiation, such as plastic that retains its structural integrity after irradiation, or metal that does not oxidize in the presence of one or more cleaning or sterilizing compounds. Nontoxic material may include material that consists of multiple layers, with layers removable for cleaning or sterilization, such as for reuse or refurbishment of the at least one substantially thermally sealed storage region. Nontoxic material may include, for example, material including metals, fabrics, papers or plastics.
Some embodiments include at least one layer of material including at least one metal on an interior surface of one or more of the at least one thermally sealed storage region. For example, the at least one metal may include gold, aluminum, copper, or silver. The at least one metal may include at least one metal composite or alloy, for example steel, stainless steel, metal matrix composites, gold alloy, aluminum alloy, copper alloy, or silver alloy. In some embodiments, the at least one metal includes metal foil, such as titanium foil, aluminum foil, silver foil, or gold foil. A metal foil may be a component of a composite, such as, for example, in association with polyester film, such as polyethylene terephthalate (PET) polyester film. The at least one layer of material including at least one metal on the interior surface of at least one storage region may include at least one metal that may be sterilized or disinfected. For example, the at least one metal may be sterilized or disinfected using plasmons. For example, the at least one metal may be sterilized or disinfected using autoclaving, thermal means, or chemical means. Depending on the embodiment, the at least one layer of material including at least one metal on an interior surface of at least one storage region may include at least one metal that has specific heat transfer properties, such as a thermal radiative properties.
In some embodiments, a container includes one or more removable inserts within an interior of one or more of the at least one storage region. The removable inserts may be made of any material appropriate for the embodiment, including nontoxic materials, metal, alloy, composite, or plastic. The one or more removable inserts may include inserts that may be removed, reused or reconditioned. For example, one or more removable inserts may be removed in conjunction with the removal of at least one medicinal unit. The one or more removable inserts may include inserts that may be cleaned, sterilized, or disinfected as appropriate to the embodiment.
Some embodiments of containers as described herein may include a plurality of storage regions within the container. In some embodiments, an outer assembly including one or more sections of ultra efficient insulation material substantially defines a plurality of substantially thermally sealed medicinal storage regions. The plurality of storage regions may be, for example, of comparable size and shape or they may be of differing sizes and shapes as appropriate to the embodiment. Different storage regions may include, for example, various removable inserts, at least one layer including at least one metal on an interior surface of a storage region, or at least one layer of nontoxic material on an interior surface, in any combination or grouping.
Some embodiments may include at least one temperature indicator. Temperature indicators may be located at multiple locations relative to the container. For example, FIG. 5 depicts an integrally thermally sealed container including multiple temperature indicators 530, 540, 550. For example, at least one temperature indicator 540 may be located within one or more of the at least one storage region, at least one temperature indicator 530 may be located exterior to the container, or at least one temperature indicator 550 may be located within the structure of the container. Temperature indicators may include temperature indicating labels, which may be reversible or irreversible. Temperature indicators suitable for some embodiments may include, for example, the Environmental Indicators sold by ShockWatch Company, with headquarters in Dallas Tex., the Temperature Indicators sold by Cole-Palmer Company of Vernon Hills Ill. and the Time Temperature Indicators sold by 3M Company, with corporate headquarters in St. Paul Minn., the brochures for which are each hereby incorporated by reference. Temperature indicators suitable for some embodiments may include time-temperature indicators, such as those described in U.S. Pat. Nos. 5,709,472 and 6,042,264 to Prusik et al., titled “Time-temperature indicator device and method of manufacture” and U.S. Pat. No. 4,057,029 to Seiter, titled “Time-temperature indicator,” each of which is herein incorporated by reference. Temperature indicators may include, for example, chemically-based indicators, temperature gauges, thermometers, bimetallic strips, or thermocouples.
In some embodiments, a container such as those described herein may include one or more sensors. Sensors may be located at various positions relative to the container. For example, FIG. 5 depicts an integrally thermally sealed container including sensors 500, 510, 520. At least one sensor 510 may be located within one or more of the at least one substantially thermally sealed storage region, at least one sensor 500 may be located exterior to the container, or at least one sensor 520 may be located within the structure of the container. In some embodiments, multiple sensors may be located in multiple positions. In some embodiments, the one or more sensors includes at least one sensor of a gaseous pressure within one or more of the at least one storage region, sensor of a mass within one or more of the at least one storage region, sensor of a stored volume within one or more of the at least one storage region, sensor of a temperature within one or more of the at least one storage region, or sensor of an identity of an item within one or more of the at least one storage region. In some embodiments, at least one sensor may include a temperature sensor, such as, for example, chemical sensors, thermometers, bimetallic strips, or thermocouples. An integrally thermally sealed container may include one or more sensors such as a physical sensor component such as described in U.S. Pat. No. 6,453,749 to Petrovic et al., titled “Physical sensor component,” which is herein incorporated by reference. An integrally thermally sealed container may include one or more sensors such as a pressure sensor such as described in U.S. Pat. No. 5,900,554 to Baba et al., titled “Pressure sensor,” which is herein incorporated by reference. An integrally thermally sealed container may include one or more sensors such as a vertically integrated sensor structure such as described in U.S. Pat. No. 5,600,071 to Sooriakumar et al., titled “Vertically integrated sensor structure and method,” which is herein incorporated by reference. An integrally thermally sealed container may include one or more sensors such as a system for determining a quantity of liquid or fluid within a container, such as described in U.S. Pat. No. 5,138,559 to Kuehl et al., titled “System and method for measuring liquid mass quantity,” U.S. Pat. No. 6,050,598 to Upton, titled “Apparatus for and method of monitoring the mass quantity and density of a fluid in a closed container, and a vehicular air bag system incorporating such apparatus,” and U.S. Pat. No. 5,245,869 to Clarke et al., titled “High accuracy mass sensor for monitoring fluid quantity in storage tanks,” each of which is herein incorporated by reference. An integrally thermally sealed container may include one or more sensors of radio frequency identification (“RFID”) tags to identify material within the at least one substantially thermally sealed storage region. RFID tags are well known in the art, for example in U.S. Pat. No. 5,444,223 to Blama, titled “Radio frequency identification tag and method,” which is herein incorporated by reference.
In some embodiments, a container such as those described herein may include one or more communications devices. The one or more communications devices, may include, for example, one or more recording devices, one or more transmission devices, one or more display devices, or one or more receivers. Communications devices may include, for example, communication devices that allow a user to detect information about the container visually, auditorily, or via signal to a remote device. For example, FIG. 5 depicts remote display device 580. Some embodiments may include more than one type of communications device, and in some embodiments the devices may be operably linked. For example, some embodiments may contain both a receiver and an operably linked transmission device, so that a signal may be received by the receiver which then causes a transmission to be made from the transmission device. Some embodiments may include more than one type of communications device that are not operably linked. For example, some embodiments may include a transmission device and a display device, wherein the transmission device is not operably linked to the display device. Some embodiments may include communications devices on the exterior of the container, including devices attached to the exterior of the container, devices adjacent to the exterior of the container, or devices located at a distance from the exterior of the container. Some embodiments may include communications devices located within the structure of the container. Some embodiments may include communications devices located within at least one of the one or more medicinal storage regions.
Some embodiments include a container including one or more recording devices. The one or more recording devices may include devices that are magnetic, electronic, chemical, or transcription based recording devices. Depending on the embodiment, there may be a single recording device or a plurality of recording devices. For example, FIG. 6 depicts recording devices 625, 630, 635. One or more recording device 635 may be located within one or more of the at least one substantially thermally sealed storage region, one or more recording device 625 may be located exterior to the container, or one or more recording device 630 may be located within the structure of the container. The one or more recording device may record, for example, the temperature from one or more temperature sensor, the result from one or more temperature indicator, or the gaseous pressure, mass, volume or identity of an item information from at least one sensor within the at least one storage region. In some embodiments, the one or more recording devices may be integrated with one or more sensor. For example, in some embodiments there may be one or more temperature sensors which record the highest, lowest or average temperature detected. For example, in some embodiments, there may be one or more mass sensors which record one or more mass changes within the container over time. For example, in some embodiments, there may be one or more gaseous pressure sensors which record one or more gaseous pressure changes within the container over time.
Some embodiments include a container including one or more transmission device. There may be a single transmission device or a plurality of transmission devices. Transmission devices may be located in a number of positions. For example, FIG. 6 depicts transmission devices 650, 655, 660. One or more transmission device 650 may be located within at least one substantially thermally sealed storage region, one or more transmission device 660 may be located exterior to the container, or one or more transmission device 655 may be located within the structure of the container. The one or more transmission device may transmit any signal or information, for example, the temperature from one or more temperature sensor, or the gaseous pressure, mass, volume or identity of an item or information from at least one sensor within the at least one storage region. In some embodiments, the one or more transmission device may be integrated with one or more sensor, or one or more recording device. The one or more transmission devices may transmit by any means known in the art, for example, but not limited to, via radio frequency (e.g. RFID tags), magnetic field, electromagnetic radiation, electromagnetic waves, sonic waves, or radioactivity.
In some embodiments an integrally thermally sealed container may include one or more display devices. Display devices may be located at a number of locations relative to the container. For example, with reference to FIGS. 5 and 6, in some embodiments, the one or more display devices 560, 640 may be located within one or more of the at least one substantially thermally sealed storage region. In some embodiments, the one or more display devices 570, 645 may be located on the exterior of the container. In some embodiments, one or more display devices may be integrated with one or more sensor. For example, in some embodiments one or more display devices may show temperature information. In some embodiments, one or more display devices may be integrated with one or more recording devices. For example, a recording device may include a visual printing, such as a graph, which is visualized with a display device, such as a window-like covering. For example, a recording device may include a digital display which indicates some aspects of the information being recorded in real-time or over a time interval. In some embodiments, the one or more display devices 580, 675 may be located at a distance from the container. For example, one or more display devices located at a distance from the container 580, 675 may display data transmitted from one or more transmission device. Display devices located at a distance may include, for example, electronic displays or computer displays. In some embodiments, data from one or more transmission device may be stored in an analog or digital medium for later display to a user. For example, data transmitted from one or more transmission device may be stored on a remote computer system for display at a later time as requested by a system or a user.
In some embodiments, an integrally thermally sealed container may include one or more receivers. For example, one or more receivers may include devices that detect sonic waves, electromagnetic waves, radio signals, electrical signals, magnetic pulses, or radioactivity. Depending on the embodiment, one or more receiver may be located within one or more of the at least one substantially thermally sealed storage region. In some embodiments, one or more receivers may be located within the structure of the container. In some embodiments, the one or more receivers may be located on the exterior of the container. In some embodiments, the one or more receiver may be operably coupled to another device, such as for example one or more display devices, recording devices or transmission devices. For example, a receiver may be operably coupled to a display device on the exterior of the container so that when an appropriate signal is received, the display device indicates data, such as time or temperature data. For example, a receiver may be operably coupled to a transmission device so that when an appropriate signal is received, the transmission device transmits data, such as location, time, or positional data.
In some embodiments, there may be at least one region within an interior of a container such as those disclosed herein that is at a higher gaseous pressure than an atmospheric pressure external to the container. In some embodiments, there may be at least one compartment within one or more of the at least one medicinal storage region, wherein the at least one compartment is at a higher gaseous pressure than an exterior atmospheric pressure of the container. For example, in reference to FIGS. 7 and 8, the gaseous pressure in a medicinal storage region 700, 800, or within intermediate regions 710, 720, 730, or 810 may be at a higher gaseous pressure than an atmospheric pressure external to the container. For example, a region of higher gaseous pressure may include a sealed region with inherently higher gaseous pressure. For example, a region of higher gaseous pressure may include at least one medicinal storage region including positive gaseous pressure relative to an atmospheric pressure external to the container. For example, a region of higher gaseous pressure may include at least one medicinal storage region including one or more sealed storage units with interior positive gaseous pressure relative to an atmospheric pressure external to the container. In some embodiments, there may be at least one region within the interior of the container that is at a lower atmospheric pressure than the atmospheric pressure external to the container. For example, in reference to FIGS. 7 and 8, the gaseous pressure in a storage region 700, 800, or within regions 710, 720, 730, or 810 may be at a lower gaseous pressure than an atmospheric pressure external to the container. For example, a region of lower gaseous pressure may include at least one medicinal storage region including negative gaseous pressure relative to an atmospheric pressure external to the container. For example, a region of lower gaseous pressure may include at least one medicinal storage region including one or more sealed storage units with interior negative gaseous pressure relative to an atmospheric pressure external to the container.
In some embodiments, a medicinal storage container may include at least one operable attachment to a medicinal dispensing device. For example, a medicinal storage container may include a region which may be attached to a needle-less or needle-free dispenser, including a needle-less injector, for selectable dispensation of a medicinal. For example, a medicinal storage container may include a region which may be attached to a liquid dispenser of oral dosages of a medicinal agent, for example a tube-like unit that allows for the flow of a medicinal liquid to a dispenser for appropriate dosage measure. For example, a medicinal storage container may include a region which may be attached to a liquid dispenser for intravenous administration of a medicinal, such as a tube-like unit that may be attached to an intravenous needle, pump or port. In some embodiments, a medicinal storage container may store multiple types of medicinal units and the container may include multiple operable attachments for various types of medicinal units, such as various tube-like attachments with various size and shape openings as appropriate for various medicinal units in different liquid, semi-solid, powder or gel-like forms.
With reference now to FIGS. 2A and 2B, shown is an example of an integrally thermally sealed medicinal storage container. FIGS. 2A and 2B depict an integrally thermally sealed medicinal storage container including one or more segments of an ultra efficient insulation material 200 principally defining at least one integrally thermally sealed medicinal storage region 210. FIG. 2A depicts a cross section view of an integrally thermally sealed medicinal storage container illustrating ultra efficient insulation material 200 wrapped in a circular or ball-like shape to principally define a substantially thermally sealed storage region 210. FIG. 2B illustrates an external view of the integrally thermally sealed medicinal storage container shown in FIG. 2A, with a cut-away section depicting the interior of the container. Although the integrally thermally sealed medicinal storage container depicted in FIGS. 2A and 2B is in a circular or ball-like shape, in some embodiments the container may be in an oblong, egg-like or other shape. As shown in FIGS. 2A and 2B, the container may contain one or more heat sink units 220, or it may contain no heat sink units. The integrally thermally sealed medicinal storage container, in some embodiments, may include no active cooling units. Although the integrally thermally sealed medicinal storage container depicted in FIGS. 2A and 2B contains one storage region 210, in some embodiments a container may include multiple storage regions, which may be of similar or different size and shape to each other. In some embodiments, there may be a plurality of storage regions within the container.
In some embodiments, an integrally thermally sealed container may include one or more segments of an ultra efficient insulation material, wherein at least one of the one or more segments of the ultra efficient insulation material substantially define one or more storage regions, and at least one of the one or more segments of an ultra efficient insulation material passes entirely around a perimeter of the one or more storage regions. With reference now to FIGS. 2A, 2B and 6, an integrally thermally sealed container may include one or more segments of an ultra efficient insulation material, wherein at least one of the one or more segments of the ultra efficient insulation material substantially define one or more storage regions, and at least one of the one or more segments of an ultra efficient insulation material passes entirely around a perimeter of the one or more storage regions. For example, FIG. 6 illustrates segment 600 of an ultra efficient insulation material, wherein the segment 600 substantially defines storage regions 610, 615, and 620. In some embodiments, there may be one or more regions of substantially thermally sealed connections (such as depicted as 605) between at least one of the one or more surface regions of the one or more segments of an ultra efficient insulation material. Some embodiments may include wherein the one or more segments of an ultra efficient insulation material passes entirely around a circumference of the one or more storage regions at least twice. As illustrated in FIGS. 2 and 6, an integrally thermally sealed container may include no active cooling units. As illustrated in FIGS. 2 and 6, an integrally thermally sealed container may include one or more heat sink units 220, 680. In some embodiments, an integrally thermally sealed container may include no heat sink units. In some embodiments, an ultra efficient insulation material may include at least one superinsulation material. In some embodiments, an ultra efficient insulation material may include at least two layers of thermal reflective material separated from each other by magnetic suspension. In some embodiments, an integrally thermally sealed container may include at least one layer of nontoxic material, such as depicted as 670, on an interior surface of a substantially thermally sealed storage region. In some embodiments, an integrally thermally sealed container may include at least one marking, such as depicted as 665, indicating a region where the container may be broken open to release stored material within the integrally thermally sealed medicinal storage region. In some embodiments, an integrally thermally sealed container may include at least one temperature indicator. In some embodiments, an integrally thermally sealed container may include one or more sensors, wherein the one or more sensors includes at least one sensor of gaseous pressure within one or more of the at least one storage region, sensor of a mass within one or more of the at least one storage region, sensor of a stored volume within one or more of the at least one storage region, or sensor of an identity of an item within one or more of the at least one storage region. In some embodiments, an integrally thermally sealed container may include one or more recording devices, for example such as depicted as 625, 630, and 635. In some embodiments, an integrally thermally sealed container may include one or more transmission devices, for example such as those depicted as 650, 655, and 660. In some embodiments, an integrally thermally sealed container may include one or more display devices, for example such as those depicted as 640, 645, and 675.
As depicted for example in FIG. 3, in some embodiments an integrally thermally sealed medicinal storage container may include one or more regions of substantially thermally sealed connections 310, 320 between at least one of the one or more surface regions of one or more segments of an ultra efficient insulation material 300, 330 wherein the one or more regions of substantially thermally sealed connections 310, 320 and the one or more segments 300, 330 form at least one integrally thermally sealed medicinal storage region 340. The one or more regions of substantially thermally sealed connections 310, 320 may include multiple components, such as one or more structural sections 310 and one or more sealing connection sections 320. In some embodiments, either or both of the one or more structural sections 310 and one or more sealing connection sections 320 may include ultra efficient insulation material. In some embodiments, either or both of the one or more structural sections 310 and one or more sealing connection sections 320 may include adhesives, glues, foams, gels, composites or other materials. Although the container depicted in FIG. 3 is illustrated in cross-section, it will be apparent that the one or more structural sections 310 and one or more sealing connection sections 320 form substantially thermally sealed connections around the circumference of the container or as needed in a specific embodiment to create substantially thermally sealed connections. Although the one or more regions of substantially thermally sealed connections depicted in FIG. 3 include multiple components, in some embodiments the one or more regions of substantially thermally sealed connections would include crimps, twists, welds or other structure to form one or more regions of substantially thermally sealed connections between one or more surface regions of the one or more segments of first ultra efficient insulation material 300, 330. The substantially thermally sealed connections may provide extremely low heat conductance and extremely low heat radiation transfer between integrally thermally sealed medicinal storage regions. The substantially thermally sealed connections may provide virtually zero heat conductance and virtually zero heat radiation transfer between substantially thermally sealed medicinal storage regions. In some embodiments, the substantially thermally sealed connections will allow less heat leak than the entire remainder of the container. In some embodiments, the substantially thermally sealed connections may double the heat seal relative to the remainder of the structure. For example, the heat leak through the substantially thermally sealed connections may be a factor of about 0.5 to a factor of about 2.0 relative to the heat leak through the remainder of the container. For example, the heat leak through the substantially thermally sealed connections may be a factor of about 0.1 to a factor of about 0.5 relative to the heat leak through the remainder of the container. The substantially thermally sealed connections may include any material or structure appropriate to the embodiment, for example: glues; adhesives; fasteners; welds; at least one layer of an ultra efficient insulation material; or at least one layer of a superinsulation material.
In some embodiments, an integrally thermally sealed medicinal storage container may include one or more segments of an ultra efficient insulation material principally defining at least one medicinal storage region, and at least one edge seal, including one or more segments of a second ultra efficient insulation material in proximity to at least one edge of the one or more segments of the first ultra efficient insulation material, and substantially thermally sealed connections between the one or more segments of the first ultra efficient insulation material and the one or more segments of the second ultra efficient insulation material. With reference now to FIGS. 4 and 5, an integrally thermally sealed medicinal storage container may include one or more segments of an ultra efficient insulation material 400, 470 principally defining at least one substantially thermally sealed medicinal storage region, and at least one edge seal 410, wherein the edge seal includes one or more segments of a second ultra efficient insulation material in proximity to at least one edge of the one or more segments of the first ultra efficient insulation material, and substantially thermally sealed connections 450 between the one or more segments of first ultra efficient insulation material and the one or more segments of second ultra efficient insulation material. In some embodiments, the first ultra efficient insulation material is substantially the same as the second ultra efficient insulation material. In some embodiments, the first ultra efficient insulation material includes at least one superinsulation material. In some embodiments, the first ultra efficient insulation material includes at least two layers of thermal reflective material separated from each other by magnetic suspension. In some embodiments, the integrally thermally sealed container includes no active cooling units. In some embodiments, the integrally thermally sealed container includes no heat sink units. In some embodiments, the one or more regions of substantially thermally sealed connections principally define at least one substantially thermally sealed medicinal storage region 420, 430, 440. In some embodiments, there are a plurality of storage regions within the container. Some embodiments may include a layer of nontoxic material (e.g. 490) on an interior surface of one or more of the at least one substantially thermally sealed storage region. Some embodiments may include at least one marking 460 indicating a region where the container may be broken open, punctured or cracked to release stored material within one or more of the at least one substantially thermally sealed storage region.
With reference now for example to FIG. 4, in some embodiments an integrally thermally sealed medicinal storage container may include one or more regions of substantially thermally sealed connections 450, 480, between the at least one of the one or more surface regions of the one or more segments of first ultra efficient insulation material 400 and the one or more segments of second ultra efficient insulation material 470 wherein the one or more regions of substantially thermally sealed connections 450, 480 and the one or more segments 400, 470 form at least one integrally thermally sealed medicinal storage region 420, 430, 440. The substantially thermally sealed connections may provide extremely low heat conductance and extremely low heat radiation transfer between integrally thermally sealed medicinal storage regions. The substantially thermally sealed connections may provide virtually zero heat conductance and virtually zero heat radiation transfer between substantially thermally sealed medicinal storage regions. In some embodiments, the substantially thermally sealed connections will allow less heat leak than the entire remainder of the container. In some embodiments, the substantially thermally sealed connections may double the heat seal relative to the remainder of the structure. For example, the heat leak through the substantially thermally sealed connections may be a factor of about 0.5 to a factor of about 2.0 relative to the heat leak through the remainder of the container. For example, the heat leak through the substantially thermally sealed connections may be a factor of about 0.1 to a factor of about 0.5 relative to the heat leak through the remainder of the container. The substantially thermally sealed connections may include any material or structure appropriate to the embodiment, for example: glues; adhesives; fasteners; welds; at least one layer of an ultra efficient insulation material; or at least one layer of a superinsulation material. In some embodiments, one or more regions of substantially thermally sealed connections may include physical structure to encourage at least one connection between the one or more segments of first ultra efficient insulation material and the one or more segments of second ultra insulation material, for example ridges, notches, strips, tongues, ribs, grooves or indentations on the surface regions of one or more segments of first ultra efficient insulation material which mate with ridges, notches, strips, tongues, ribs, grooves or indentations on the surface regions of one or more segments of second ultra insulation material to form at least one connection. In some embodiments, there are a plurality of medicinal storage regions 420, 430, 440 within the container. Although the plurality of medicinal storage regions 420, 430, 440 shown in FIGS. 4 and 5 are of similar size and shape, there may be a plurality of medicinal storage regions in varying sizes and shapes, depending on the embodiment.
Some embodiments include at least one marking indicating a region where an integrally thermally sealed container may be broken open to release stored material within one or more of the at least one substantially thermally sealed storage region. For example, FIG. 4 depicts marking 460 on the exterior of the container. The at least one marking may include superficial markings on the exterior of the container, such as those indicated with superficial colorations on the exterior of the container, for example, markings painted or stamped on the exterior of the container. The at least one marking may include markings that include the interior of the container, including markings that may alter the structure of the container such as scratches or perforations. The at least one marking may include superficial markings on the exterior of the container that indicate one or more locations on the container which are amenable to pressure or force due to structural aspects of the interior of the container which are not visible from the exterior of the container, for example superficial markings that indicate regions where a container may be pushed, twisted, punctured or cut in alignment with interior structures to break open the container to release stored material from one or more of the at least one substantially thermally sealed storage region.
FIG. 5 depicts further features of possible embodiments of an integrally thermally sealed medicinal storage container such as that depicted in FIG. 4. Some embodiments may include at least one temperature indicator 530, 540, 550. Some embodiments may include one or more sensors 500, 510, 520. In some embodiments, the one or more sensors (e.g. 500, 510, 520) include at least one sensor of gaseous pressure within one or more of the at least one substantially thermally sealed storage region, sensor of a mass within one or more of the at least one substantially thermally sealed storage region, sensor of a stored volume within one or more of the at least one substantially thermally sealed storage region, or sensor of an identity of an item within one or more of the at least one substantially thermally sealed storage region. In some embodiments, the integrally thermally sealed container includes one or more recording devices. In some embodiments, the integrally thermally sealed container includes one or more transmission devices. In some embodiments, the integrally thermally sealed container includes one or more display devices 560, 570, 580. A display device may be located remotely from the container, such as the one depicted as 580.
A medicinal storage container may include an outer assembly including one or more sections of ultra efficient insulation material substantially defining at least one substantially thermally sealed medicinal storage region, and an inner assembly including one or more interlocks configured to provide controllable egress of a quantity of a material from one or more of the at least one thermally sealed medicinal storage region. A medicinal storage container may include one or more medicinal units, for example pills, capsules, syringes containing medicinals, unijets containing medicinals, vaccine vials, medicinal vials, patches or bandages, or packages containing any of these. One or more medicinal units may be stored at a temperature between approximately 2° Centigrade and approximately 8° Centigrade. For example, one or more medicinal units may be stored between approximately 2° Centigrade and approximately 8° Centigrade to ensure maximum stability and efficacy of the stored medicinal material at the time of use or administration. One or more medicinal units may be stored at a temperature between approximately 2° Centigrade and approximately 8° Centigrade may include at least one of: at least one vaccine vial, at least one medicinal vial, at least one medicinal syringe, at least one needless injector, or at least one unijet.
As used herein, an “interlock” includes at least one connection between regions, wherein the interlock acts so that the motion or operation of one part is constrained by another. An interlock may be in an open position, allowing the movement of material from one region to another, or an interlock may be in a closed position to restrict the movement or transfer of material. In some embodiments, an interlock may have intermediate stages or intermediate open positions to regulate or control the movement of material. For example, an interlock may have at least one position that restricts egress of a discrete quantity of a material from at least one storage region. For example, an interlock may act to restrict the egress of a stored unit of a material from a storage region until another previously-stored unit of a material egresses from the container. For example, an interlock may act to allow the egress of only a fixed quantity of stored material or stored units of material from a storage region during a period of time. At least one of the one or more interlocks may operate independently of an electrical power source, or at least one of the one or more interlocks may be electrically operable interlocks. An electrical power source may originate, for example, from municipal electrical power supplies, electric batteries, or an electrical generator device. Interlocks may be mechanically operable interlocks. For example, mechanically operable interlocks may include at least one of: electrically actuated mechanically operable interlocks, electromagnetically operable interlocks, magnetically operable interlocks, mechanically actuated interlocks, ballistically actuated interlocks, dynamically actuated interlocks, centrifugally actuated interlocks, optically actuated interlocks, orientationally actuated interlocks, thermally actuated interlocks, or gravitationally actuated interlocks. In some embodiments, at least one of the one or more interlocks includes at least one magnet.
An interlock may operate to allow the transfer or movement of material from one region to another in a unidirectional or a bidirectional manner. For example, an interlock may operate to allow the transfer of material from a storage region within a container to an intermediate region or a region external to the container in a unidirectional manner, while restricting the transfer or movement of material from a region external to the container into the container. For example, an interlock may operate to allow the transfer of material into at least one storage region within a container, such as for refilling or recharging a supply of material stored within the container. For example, an interlock may operate to restrict the egress of stored material from a storage region while allowing for the ingress of a heat sink material such as dry ice, wet ice, liquid nitrogen, or other heat sink material. For example, an interlock may operate to restrict the egress of stored material from a storage region while allowing the ingress of gas or vapor, such as to equalize the gaseous pressure within at least one region within the container with a gaseous pressure external to the container.
For example, FIG. 7 illustrates an example of a substantially thermally sealed storage container, including an outer assembly 780 substantially defining a thermally sealed storage region 700. FIG. 7 depicts interlocks 745, 755, 765, 775 configured to provide controllable egress of a discrete quantity of material from the storage region 700. Interlocks 745, 755, 765, 775 are configured to provide controllable egress through regions 740, 750, 760 and 770 respectively. In some embodiments, there may be two or more intermediate regions one or more of the at least one substantially thermally sealed storage region of the container and the exterior of the container. The interlocks 745, 755, 765, 775 depicted in FIG. 7 are adjacent to intermediate regions 730, 720, 710. FIG. 7 depicts optional sensors 785, 793, and 797. Some embodiments may include at least one heat sink unit such as illustrated as 790.
Some embodiments include a medicinal storage container, including an outer assembly including one or more sections of ultra efficient insulation material defining at least one substantially thermally sealed medicinal storage region; and an inner assembly including one or more interlocks, wherein the one or more interlocks includes one or more first selectively operable passageway between one or more of the at least one storage region and at least one intermediate region, one or more second selectively operable passageway between the at least one intermediate region and an exterior of the container, and one or more actuators operably coupled to one or more of the at least one first or second selectively operable passageway configured to open or close said passageway. At least one of the actuators may be a mechanical actuator. At least one of the one or more actuators may include at least one of: electrically actuated mechanically operable actuators, electromagnetically operable actuators, magnetically operable actuators, mechanically actuated actuators, ballistically actuated actuators, dynamically actuated actuators, centrifugally actuated actuators, optically actuated actuators, orientationally actuated actuators, thermally actuated actuators, or gravitationally actuated actuators. For example, a magnetically operable actuator may include a magnetic switching component, so that the actuator opens or closes at least one passageway when the container is in proximity to a magnetic field, such as when a magnet is moved across an outer surface of the container. For example, a gravitationally actuated actuator may include at least one component which is weighted so that the actuator opens or closes at least one passageway when the container is in a particular orientation relative to the earth's gravitational field. For example, a gravitationally actuated actuator may close at least one passageway when the container is in an upright orientation and close the at least one passageway when the container is in a sideways orientation.
FIGS. 8A and 8B depict a medicinal storage container including an outer assembly 870 including one or more sections of ultra efficient insulation material substantially defining at least one medicinal storage region 800 and an inner assembly including one or more interlocks 825, 835 configured to provide controllable egress of a quantity of a material from one or more of the at least one substantially thermally sealed medicinal storage region 800. As depicted in FIGS. 8A and 8B, a container may include a rotatable region 850 which may rotate through a thermally sealed rotation region 860. For example a thermally sealed rotation region 860 may include hinges, curves or grooves to allow for movement of rotatable region 850 around an axis of the at least one medicinal storage region 800. Interlock 825 includes a selectively operable passageway 820 between medicinal storage region 800 and intermediate region 810. As depicted in FIG. 8B, when the rotatable region 850 is in a position to allow for alignment of interlock 835 with mechanical actuator 845, mechanical actuator 845 may be operably coupled to the selectively operable passageway formed by regions 830, 840 between intermediate region 810 and the exterior of the container. As depicted in FIG. 8A, rotatable region 850 also may be in a position to not allow alignment of interlock 835 with mechanical actuator 845. Rotatable region 850 may therefore include an externally-operable closure operably coupled to one or more of the at least one second selectively operable passageway. As may be readily apparent from FIGS. 8A and 8B, material stored in the medicinal storage region may include liquids, fluids, semi-fluids, solids, semi-solids, particulates, or medicinal storage units (e.g. one or more packaged medicinal units).
FIG. 9 depicts a medicinal storage container with an outer assembly including sections of ultra efficient insulation material 900, 940 substantially defining a medicinal storage region 935, and an inner assembly including one or more interlocks 910 configured to provide controllable egress of a quantity of material (as depicted by triangles e.g. 903) from the storage region 935. The container depicted in FIG. 9 includes sections of ultra efficient insulation material 900, 940 attached via thermally insulating attachment regions 945. FIG. 9 depicts a passageway 905 between medicinal storage region 935 and intermediate region 925. The movement of stored material 903 though passageway 905 may be controlled by closure 930. In some embodiments, closure 930 may be externally-operable, for example via direct force, remote electronic control, remote magnetic control or shifting the alignment of the container relative to the earth's gravitational field. Material 920 in the intermediate region 925 may have controllable egress from intermediate region 925 via interlock 910. As depicted in FIG. 9, material 920 may align with an appropriately sized and shaped region 915 of interlock 910, and interlock 910 may then rotate to allow for the egress of material (e.g. 950). Interlock 910 may be externally-operable, for example the rotation of interlock 910 may be via mechanical force, magnetic force, gravitational force, thermal energy, optical force, dynamic force or electromagnetic force, or other externally-operable forces. Although FIG. 9 illustrates multiple medicinal units stored in the storage region 935, in some embodiments there may be a liquid, fluid, multiple medicinal units of different size, multiple medicinal units of different shape, or a single medicinal unit stored in storage region 435.
In some embodiments, a medicinal storage container includes a structural assembly including one or more sections of ultra efficient insulation material primarily defining at least one substantially thermally sealed medicinal storage region, an inner assembly including one or more interlocks configured to provide controllable egress of a quantity of a material from one or more of the at least one thermally sealed medicinal storage region, and an outlet assembly including one or more outlet channels, wherein the one or more outlet channels are arranged to provide controllable egress of a quantity of a medicinal material from the at least one medicinal storage region, and the one or more outlet channels substantially follow an extended thermal pathway. For example, an extended thermal pathway may have a high aspect ratio. For example, as illustrated in FIG. 10, views 10A, 10B and 10C, a substantially thermally sealed container includes an outlet channel 1010 to provide controllable egress of a quantity of a stored material from the at least one medicinal storage region 1040. View 10A depicts a top-down cross-section view of a medicinal storage container, view 10B depicts a side-facing cross-section view of the container, and view 10C depicts an external side-facing view of the container. In some embodiments, a medicinal storage container includes inner assembly including one or more interlocks configured to provide controllable egress of a quantity of a material from one or more of the at least one thermally sealed medicinal storage region. For example, FIG. 10 shows a substantially thermally sealed container including an outlet channel 1010 and an interlock 1000 between the outlet channel and the at least one thermally sealed medicinal storage region 1040. In some embodiments, a medicinal storage container includes at least one externally-controllable opening between at least one of the one or more outlet channels and the exterior of the container. For example, FIG. 10 shows a medicinal storage container including an outlet channel 1010 and an externally-controllable opening 1020 between the outlet channel and the exterior of the container. A medicinal storage container may include a sealable cover 1030 for an externally-controllable opening 1020. A sealable cover for an externally-controllable opening may include a thermally sealable cover, and may include at least one ultra efficient insulation material.
FIG. 11 depicts some aspects of a medicinal storage container. Embodiments may include a medicinal storage container including one or more segments of an ultra efficient insulation material shaped to define at least one substantially temperature-stabilized medicinal storage region, and at least one access region, including at least one region of the one or more segments of an ultra efficient insulation material configured for at least one perforation by a perforation device, wherein one or more of the at least one perforation is configured to provide for a controlled egress of a quantity of a medicinal material from the at least one substantially temperature-stabilized medicinal storage region.
A medicinal storage container may include at least one thermally sealable cover external to the at least one region of the one or more segments of an ultra efficient insulation material configured for at least one perforation by a perforation device, wherein the at least one thermally sealable cover includes a sealing portion positioned for mating to the at least one region of the one or more segments of an ultra efficient insulation material configured for at least one perforation by a perforation device. For example, a thermally sealable cover may include a sealing portion of a similar size and shape as the at least one region of the one or more segments of an ultra efficient insulation material configured for at least one perforation by a perforation device. For example, a thermally sealable cover may include a sealing portion that encompasses the at least one region of the one or more segments of an ultra efficient insulation material configured for at least one perforation by a perforation device. In some embodiments, the thermally sealable cover includes a second ultra efficient insulation material. An ultra efficient insulation material may be predominately the same as a second ultra efficient insulation material. Some embodiments may include at least one thermally sealable supplemental segment shaped to substantially replace the one or more segments of an ultra efficient insulation material configured for at least one perforation by a perforation device, wherein the at least one supplemental segment includes a third ultra efficient insulation material. For example, at least one supplemental segment may be of a similar size and shape as the at least one region of the one or more segments of an ultra efficient insulation material configured for at least one perforation by a perforation device. A third ultra efficient insulation material may be predominately the same as an ultra efficient insulation material.
As shown in FIGS. 11 and 14, an access region may include multiple regions 1140, 1130, 1420, 1430, 1440 of one or more segments of an ultra efficient insulation material configured for at least one perforation by a perforation device. Some embodiments may include a container with at least one exterior wall and at least one interior wall wherein one or more of the at least one exterior wall and one or more of the at least one interior wall are movable relative to each other, and the relative movement of the exterior wall to the interior wall alters the accessibility of one or more of the at least one region of the one or more segments of an ultra efficient insulation material configured for at least one perforation by a perforation device. For example, FIG. 11 depicts an exterior wall 1110 and an interior wall 1120 which may be movable relative to each other. In some embodiments, the relative movement of the at least one exterior wall and the at least one interior wall may facilitate access to the at least one storage region. For example, in FIG. 11, the relative movement of an exterior wall 1110 and an interior wall 1120 may allow the alignment of an access region, including at least one region of one or more segments of ultra-efficient insulation material configured for at least one perforation by a perforation device. In some embodiments, layers of ultra efficient insulation material may be movable relative to each other to facilitate access to the at least one medicinal storage region. For example, FIG. 14 depicts layers of ultra efficient insulation material 1420, 1430 and 1440 which are movable relative to each other along axis of rotation 1410 of the container 1400 to align and facilitate access to medicinal storage region 1450.
Some embodiments may include wherein the at least one access region includes at least one substantially tubular structure, wherein the at least one substantially tubular structure is of a size and shape to provide for controlled egress of a discrete quantity of a medicinal material from the at least one substantially temperature-stabilized storage region. A substantially tubular structure may include a tube made of a variety of materials appropriate to the embodiment, or a tube-like structure made of a variety of materials appropriate to the embodiment. In some embodiments, the at least one substantially tubular structure includes at least one hypodermic syringe. In some embodiments, one or more of the at least one substantially tubular structure are located external to the container, and may be transiently inserted from the exterior of the container to the interior of the container to provide for the controlled egress of a discrete quantity of a substance from the at least one storage region. For example, FIG. 11 depicts a movable perforation device with a substantially tubular structure 1170 located external to the container, wherein substantially tubular structure 1170 is positioned for piercing at least one region of the one or more segments of an ultra efficient insulation material configured for at least one perforation by a perforation device. In some embodiments, the one or more of the at least one substantially tubular structure are located internal to the container, and may be transiently inserted from the interior of the container to the exterior of the container to provide for the controlled egress of a discrete quantity of a substance from the at least one storage region. For example, FIG. 11 depicts a movable perforation device with a substantially tubular structure 1160 located within storage region 1100, wherein substantially tubular structure 1170 is positioned for piercing at least one region of the one or more segments of an ultra efficient insulation material configured for at least one perforation by a perforation device. There may be a plurality of movable perforation devices with at least one substantially tubular structure stored within or external to the storage structure. At least one substantially tubular structure may be replaceable.
Some embodiments of a medicinal storage container may include an ingress region, including at least one region of the one or more segments of an ultra efficient insulation material which may be displaced to allow for the transient insertion of at least one ingress structure from an exterior of the container to an interior of the at least one substantially temperature-stabilized medicinal storage region. For example, FIG. 12 depicts regions 1200, 1210, 1220, 1230 of one or more segments of an ultra efficient insulation material which may be displaced to allow for the transient insertion of ingress structure 1240 from the exterior of the container to the interior of the at least one substantially temperature-stabilized medicinal storage region 1200. In some embodiments, the access region may include the ingress region, for example an ingress region may be operably-coupled or integrally connected to an access region.
Some embodiments may include a coupling mechanism, wherein the coupling mechanism may create a coupled unit between at least one perforation device internal to the container and at least one perforation device external to the container, thereby creating an egress mechanism for material from the at least one substantially temperature-stabilized medicinal storage region. As depicted in FIG. 13, a perforation device originally external to the container 1300 and a perforation device originally internal to the container 1310 may combine between layers 120, 130 to create a coupled unit. In some embodiments, the coupling mechanism may be located within layers of the ultra efficient insulation material as depicted in FIG. 13, while in other embodiments the coupling mechanism may be otherwise located internal to the container or external to the container. In some embodiments, there may be components of the coupling mechanism located within the layers of ultra efficient insulation material, such as depicted as 1320 in FIG. 13. In some embodiments, the perforation units may create the coupling mechanism without additional components. For example, some embodiments may include perforation units that are shaped or sized to fit or align together and thereby create a coupled unit.
In some embodiments, a medicinal storage container may include at least one access region including an elongated thermal pathway. For example, the elongated thermal pathway may be a pathway for the controlled egress of a quantity of a medicinal material from the at least one substantially temperature-stabilized storage region. For example, the at least one access region including an elongated thermal pathway may be configured to include a high aspect ratio. Some embodiments may include at least one egress structure external to the container which may be transiently inserted from an exterior of the container to an interior of the container to provide for the controlled egress of a quantity of a material from the at least one storage region. The at least one egress structure external to the container may be configured to include an elongated thermal pathway for the controlled egress of a quantity of a medicinal material from the at least one substantially temperature-stabilized storage region. For example, the at least one egress structure external to the container may be configured to include a high aspect ratio.
In reference now to FIG. 15, a medicinal storage container with a medicinal storage region 1500 may include a relatively rotatable portion 1550 which may move to align segments of ultra efficient insulation material 1545, 1535 configured for at least one perforation by a perforation device. Note that the segments configured for at least one perforation by a perforation device 1545, 1535 may include the same or different material from each other. The relatively rotatable portion 1550 may be connected to the relatively fixed portion of the container via thermally insulated rotation regions 1560. For example, the thermally insulated rotation regions may include low thermal conductivity bead-like units or low thermal conductivity solids in a structure that allows rotation. The thermally insulated rotation regions may provide virtually zero heat conductance and virtually zero heat radiation transfer between substantially thermally sealed storage regions. The thermally insulated rotation regions may include any material appropriate to the embodiment, for example: glues; adhesives; fasteners; welds; at least one layer of an ultra efficient insulation material; or at least one layer of a superinsulation material. In some embodiments, one or more regions of thermally insulated rotation regions may include physical structure to encourage at least one rotatable connection between one or more segments of first ultra efficient insulation material and one or more segments of second ultra insulator material, for example ridges, notches, strips, tongues, ribs, grooves or indentations on the one or more segments of first ultra efficient insulation material which mate with ridges, notches, strips, tongues, ribs, grooves or indentations on the one or more segments of second ultra insulation material to form at least one rotatable connection. In some embodiments, the rotation of the container to align segments configured for at least one perforation by a perforation device 1545, 1535 may allow access to an intermediate portion of the container 1510. An intermediate portion of the container 1510 may have an access opening 1520 to one or more medicinal storage regions 1500. In some embodiments, the access opening 1520 may be closed through an interlock or closing mechanism 1525.
In some embodiments, a medicinal storage container includes at least one marking on the exterior of the container indicating at least one access region. For example, at least one marking may include ink, paint, UV-visible markings, coded markings, tell-tale marks or structural marks on the exterior of the container (e.g. indentations or scratch marks). In some embodiments, a medicinal storage container includes a framework attached to an exterior of the container identifying one or more of the at least one region of one or more segments of an ultra efficient insulation material configured for at least one perforation by a perforation device. For example, a framework may include an access structure or provide an appropriate alignment for perforation by a perforation device.
In some embodiments, a medicinal storage container includes at least one authentication device. An authentication device may be operably coupled to one or more communications devices, sensors, or access mechanisms. For example, an authentication device may include a device which may be authenticated with a key, or a device that may be authenticated with a code, such as a password or a combination. For example, an authentication device may include a device that may be authenticated using biometric parameters, such as fingerprints, retinal scans, hand spacing, voice recognition or biofluid composition (e.g. blood, sweat, or saliva).
In some embodiments, a medicinal storage container includes at least one logging device. A logging device may be operably coupled to one or more communications devices, sensors, perforation devices or access mechanisms. For example, a logging device may include a record of authentication via an authentication device, such as a record of times of authentication, operation of authentication or individuals making the authentication. For example, a logging device may record that an authentication device was authenticated with a specific code which identifies a specific individual at one or more specific times. For example, a logging device may record egress of a quantity of a material from one or more of at least one storage region, such as recording that some quantity or units of material egressed at a specific time. For example, a logging device may record information from one or more sensors, one or more temperature indicators, or one or more communications devices.
In some embodiments, a medicinal storage container may include at least one control ingress device, wherein the at least one control ingress device is operably connected to at least one inner assembly or portion of an inner assembly. In some embodiments, a medicinal storage container includes at least one control ingress device, wherein the at least one control ingress device may be operably connected to at least one externally-operable opening, control egress device, communications device, or other component. For example, at least one control ingress device may control ingress into the inner assembly of the container, such as ingress of: substance or material to be stored, heat sink material, one or more devices, electromagnetic radiation, gas, or vapor.
One skilled in the art will recognize that the herein described components (e.g., steps), devices, and objects and the discussion accompanying them are used as examples for the sake of conceptual clarity and that various configuration modifications are within the skill of those in the art. Consequently, as used herein, the specific exemplars set forth and the accompanying discussion are intended to be representative of their more general classes. In general, use of any specific exemplar herein is also intended to be representative of its class, and the non-inclusion of such specific components (e.g., steps), devices, and objects herein should not be taken as indicating that limitation is desired. Furthermore, the use of particular shapes within a Figure herein is not intended to connote a shape of any particular element. For example, the use of a star-shape for element 500 in FIG. 5 should not be interpreted as meaning that the element 500 in practice should be star-shaped.
All of the above U.S. patents, U.S. patent application publications, U.S. patent applications, foreign patents, foreign patent applications and non-patent publications referred to in this specification or listed in any Application Data Sheet, are incorporated herein by reference, to the extent not inconsistent herewith.
In addition to the foregoing, other system aspects are described in the claims, drawings, and text forming a part of the present disclosure.
With respect to the use of substantially any plural or singular terms herein, those having skill in the art can translate from the plural to the singular or from the singular to the plural as is appropriate to the context or application. The various singular/plural permutations are not expressly set forth herein for sake of clarity.
While particular aspects of the present subject matter described herein have been shown and described, it will be apparent to those skilled in the art that, based upon the teachings herein, changes and modifications may be made without departing from the subject matter described herein and its broader aspects and, therefore, the appended claims are to encompass within their scope all such changes and modifications as are within the true spirit and scope of the subject matter described herein. Furthermore, it is to be understood that the invention is defined by the appended claims. It will be understood by those within the art that, in general, terms used herein, and especially in the appended claims (e.g., bodies of the appended claims) are generally intended as “open” terms (e.g., the term “including” should be interpreted as “including but not limited to,” the term “having” should be interpreted as “having at least,” the term “includes” should be interpreted as “includes but is not limited to,” etc.). It will be further understood by those within the art that if a specific number of an introduced claim recitation is intended, such an intent will be explicitly recited in the claim, and in the absence of such recitation no such intent is present. For example, as an aid to understanding, the following appended claims may contain usage of the introductory phrases “at least one” and “one or more” to introduce claim recitations. However, the use of such phrases should not be construed to imply that the introduction of a claim recitation by the indefinite articles “a” or “an” limits any particular claim containing such introduced claim recitation to inventions containing only one such recitation, even when the same claim includes the introductory phrases “one or more” or “at least one” and indefinite articles such as “a” or “an” (e.g., “a” or “an” should typically be interpreted to mean “at least one” or “one or more”); the same holds true for the use of definite articles used to introduce claim recitations. In addition, even if a specific number of an introduced claim recitation is explicitly recited, those skilled in the art will recognize that such recitation should typically be interpreted to mean at least the recited number (e.g., the bare recitation of “two recitations,” without other modifiers, typically means at least two recitations, or two or more recitations). Furthermore, in those instances where a convention analogous to “at least one of A, B, and C, etc.” is used, in general such a construction is intended in the sense one having skill in the art would understand the convention (e.g., “a system having at least one of A, B, and C” would include but not be limited to systems that have A alone, B alone, C alone, A and B together, A and C together, B and C together, or A, B, and C together, etc.). In those instances where a convention analogous to “at least one of A, B, or C, etc.” is used, in general such a construction is intended in the sense one having skill in the art would understand the convention (e.g., “a system having at least one of A, B, or C” would include but not be limited to systems that have A alone, B alone, C alone, A and B together, A and C together, B and C together, or A, B, and C together, etc.). It will be further understood by those within the art that virtually any disjunctive word or phrase presenting two or more alternative terms, whether in the description, claims, or drawings, should be understood to contemplate the possibilities of including one of the terms, either of the terms, or both terms. For example, the phrase “A or B” will be understood to include the possibilities of “A” or “B” or “A and B.”

EXAMPLES

Example 1

A medicinal storage container may be used to maintain a vaccine at an optimal storage temperature. The optimal storage temperature for many vaccines including those for tuberculosis, diphtheria, tetanus, pertussis, hepatitis, influenza, measles, mumps, rubella, and polio, for example, ranges from 2 to 8° C. (Center for Disease Control/Department of Health & Human Services, Vaccine Management: Recommendations for storage and handling of selected biologicals (January 2007), which is herein incorporated by reference). A vaccine may lose potency upon exposure to inappropriate temperature conditions and the loss in vaccine potency is dependent, for example, upon whether an adjuvant is present, whether the vaccine is live or inactivated and whether the vaccine is liquid or lyophilized (Pickering et al., Too hot, too cold: Issues with vaccine storage, Pediatrics 118:1738-1739 (2006), which is herein incorporated by reference). For example, live attenuated vaccines are stable at freezing temperatures but lose potency after exposure to temperatures above the recommended range. In contrast, vaccines containing aluminum adjuvants irreversibly lose potency when exposed to freezing temperatures. Maintaining a vaccine at a constant temperature between 2 to 8° C. from the time it is manufactured to the time it is administered to a patient poses a challenge for both industrialized as well as developing countries. In one study, for example, 20% of physician offices or health care facilities in Ontario, Canada did not meet the necessary requirements for vaccine storage and handling, including having refrigerators that were either too hot or too cold for safe vaccine storage and leaving vaccines out of the refrigerator for too long (Weir & Hatch, Preventing cold chain failure: vaccine storage and handling, JAMC 171:1050 (2004), which is herein incorporated by reference). In a developing or resource-limited country or region, the challenges are even greater with potentially limited refrigeration and often extreme heat and humidity.

Example 2

A medicinal storage container may be used to maintain a vaccine at a temperature of 2 to 8° C. for use in an industrialized, developing or resource-limited country or region. For example, the World Health Organization (WHO) currently recommends the following vaccinations for children from birth to nine months of age: BCG (tuberculosis), oral polio (in endemic countries), diphtheria-tetanus-pertussis, hepatitis B, Haemophilus influenzae type B, yellow fever (where this disease poses a threat), and measles (Disease Control Priorities Project). As such, a single dose of a vaccine may be stored in an integrally sealed medicinal storage container and may be packaged, for example, in a preloaded, single-use syringe, a vial, or a single-dose injection device such as, for example, the Uniject (see, e.g. Levin et al., The costs of home delivery of a birth dose of hepatitis B vaccine in a prefilled syringe in Indonesia, Bull. World Health Org. 83:456-461 (2005), which is herein incorporated by reference). Alternatively, multiple doses of a vaccine may be enclosed in an integrally sealed medicinal storage container for use by multiple individuals on a given day. As such, the vaccine may be packaged as single dose units, as described above or as multi-dose units in, for example, a multi-dose vial. A medicinal storage container may contain only a single type of vaccine. Alternatively, a medicinal storage container may contain multiple vaccines intended to be administered all at once, for example, to a child of a particular age. Optionally, multiple single or multi-dose units of a vaccine or vaccines may be enclosed in a medicinal storage container and as such a single unit or multiple units may be dispensed over time without compromising the temperature stability of the remaining units. In some instances, single or multiple doses of a vaccine may be directly packaged in a medicinal storage container and accessed via an access region of the container.

Example 3

A medicinal storage container may be used to maintain oral medications such as, for example, tablets or capsules at an optimal temperature. The shelf-life or expiration date of a medication is based on specified storage requirements. While temperate climate conditions generally satisfy these requirements, the potentially extreme heat and humidity of tropical climates in resource-limited areas lacking appropriate storage capability may significantly increase the rate of drug decomposition and consequently decrease the expected shelf-life. For example, three month exposure of tablets and capsules of the antibiotics sulphathathiazole, tetracycline hydrochloride, and chloramphenicol to a temperature of 30° C. and relative humidity of 75% decreases the shelf-lives of these drugs from 6-30 months down to 2.5-9 months (Ette, Conscience, the law, and donation of expired drugs, Ann. Pharmacother. 38:1310-1313 (2004), which is herein incorporated by reference). As such, a medicinal storage container may be used in extreme tropical conditions, for example, to maintain a medication at a temperature consistent with an optimal shelf life.

Example 4

A medicinal storage container may be used, for example, to maintain a drug or drugs used for the treatment of HIV/AIDS at or below 25° C. For example, the combination of lopinavir and ritonavir, one of several anti-retroviral options recommended by the WHO for the treatment of HIV/AIDS in developing or resource-limited countries, is optimally stored at 2-8° C. until dispensing, after which it may be kept at 25° C. or less for approximately two months. However, sustained exposure of lopinavir/ritonavir to 35° C. for eight weeks, for example, results in a 10-20% loss in drug potency, while exposure to as little as 7 days at 45° C. results in a 40% reduction in potency and physical melting of the capsules (Pau et al., Instability of lopinavir/ritonavir capsules at ambient temperatures in sub-Saharan Africa: relevance to WHO antiretroviral guidelines, AIDS (2005) 19:1233-1234, which is herein incorporated by reference). As such, a single dose of an HIV/AIDS medication or medication combination may be enclosed in an integrally sealed medicinal storage container. Alternatively, multiple doses of an HIV/AIDS medication or medication combination may be enclosed in an integrally sealed medicinal storage container for use by multiple individuals on a given day, or for dosing one individual over a short time frame such as, for example, several days to a week. Multiple doses of an HIV/AIDS medication or medication combination may be optionally enclosed in a medicinal storage container and as such a single unit or multiple units may be dispensed over time without compromising the temperature of the remaining stored units.

Example 5

A medicinal storage container may also be used to maintain oral medications used for the treatment of malaria, for example, at an optimal temperature. For example, chloroquine in tablet form is commonly used for the treatment of malaria in developing countries, but loses as much as 50% of its bioavailability after 6 months of storage at 40° C. and 75% relative humidity (Risha et al., In vitro evaluation of the quality of essential drugs on the Tanzanian market, Trop. Med. Int. Health 7:701-707 (2002), which is herein incorporated by reference). Sulfadoxine and pyrimethamine, a common anti-malarial combination, may also experience decreased bioavailability after sustained exposure to the heat and humidity commonly encountered in tropical climates (Risha et al., In vitro evaluation of the quality of essential drugs on the Tanzanian market, Trop. Med. Int. Health 7:701-707 (2002), which is herein incorporated by reference). As such, a single dose of an anti-malarial medication or medication combination may be enclosed in an integrally sealed medicinal storage container. Alternatively, multiple doses of an anti-malarial medication or medication combination may be enclosed in an integrally sealed medicinal storage container for use by multiple individuals on a given day, or for dosing one individual over a short period of time such as, for example, a 3 to 5 day treatment course (see, e.g. Llanos-Cuentas et al., Atovaquone and proguanil hydrochloride compared with chloroquine or pyrimethamine/sulfadoxine for treatment of acute Plasmodium falciparum malaria in Peru, Braz. J. Infect. Dis. 5:67:72 (2001), which is herein incorporated by reference). Multiple doses of an anti-malarial medication or medication combination may be optionally enclosed in a medicinal storage container and as such a single unit or multiple units may be dispensed over time without compromising the temperature of the remaining units.

Example 6

A medicinal storage container may also be used to maintain oral medications such as, for example, oral solutions used for pediatric care at an optimal temperature. For example, an oral solution of stavudine is commonly used for treating young children with HIV/AIDS in developing countries, but loses 84% of its activity after 2 weeks of storage at 35° C. (Lockman et al., Stability of didanosine and stavudine pediatric oral solutions and Kaletra capsules at temperatures from 4° C. to 55° C. Conf. Retrovir. Opportunistic Infect. (2005) Feb. 22-25; 12: abstract no. 668, which is herein incorporated by reference). In some instances, an oral solution might be a vaccine such as, for example, an oral polio vaccine or a rotavirus vaccine. As such, a single dose of an oral solution medication such as an HIV/AIDS medication or vaccine, for example, may be enclosed in an integrally thermally sealed medicinal storage container to maintain an optimal storage temperature, for example, of 2 to 8° C. In some instances, the optimal temperature may range from 2 to 25° C. The solution may be directly packaged in a medicinal storage container. Alternatively, the solution may be separately packaged in a tube, cup, vial, or other dosing unit. Optionally, multiple doses of an oral solution medication may be enclosed in an integrally sealed medicinal storage container, either with or without separate packaging, for use by multiple individuals on a given day, or for dosing one individual over a short time frame such as, for example, several days to a week. Multiple doses of an oral solution medication may be optionally enclosed in a medicinal storage container and as such a single unit or multiple units may be dispensed over time without compromising the temperature of the remaining units. Optionally, a single or multiple doses of an oral solution medication may be stored in medicinal storage container with an access region, as described herein.

Example 7

A medicinal storage container may be used to maintain prepackaged single use injectable medications at an optimal storage temperature. For example, a medicinal storage container may contain single doses of depot-medroxyprogesterone (DMPA-SC) (birth control), Hepatitis B vaccines, oxytocin (postpartum hemorrhage prevention), and gentamicin (sepsis prevention in neonates) prefilled, for example, in a Uniject syringe device (see, e.g. PATH, The Radically Simple Uniject™ Device; Levin et al., The costs of home delivery of a birth dose of hepatitis B vaccine in a prefilled syringe in Indonesia, Bull. World Health Org., 83:456-462 (2005); and Bang et al., Effect of home-based neonatal care and management of sepsis on neonatal mortality: field trial in rural India, Lancet, 354:1955-1961 (1999), which are each herein incorporated by reference). As such, one or more single-dose, prepackaged injectable medication devices may be stored at an optimal temperature in an integrally thermally sealed medicinal storage container. Optionally, one or more prepackaged injectable medication devices may be stored at an optimal temperature in a medicinal storage container with an inner assembly as described herein. Alternatively, a medicinal storage container may maintain cartridges, vials, or ampules at an optimal temperature for use with a needle-free injection device, for example. A medicinal storage container may include an operable attachment to a medicinal dispensing device, such as a needle-free injection device.

Example 8

A medicinal storage container may be used to maintain a diagnostic test kit or kits, for example, at an optimal storage temperature. A diagnostic kit might be a rapid diagnostic test, for example, such as those used to screen for malaria, HIV, hepatitis B, and syphilis in developing or resource-limited countries. These diagnostic kits are optimally stored in a temperature range of 2° C. to 30° C., but the anticipated shelf-life of any given kit is dependent upon maintaining the product within the optimal temperature range. This poses a challenge in remote or resource-limited parts of the world where temperatures may easily exceed 35° C. in summer months, with little or no available refrigeration. For example, investigators have found that malaria rapid diagnostic tests are routinely stored for extended periods of time above 30° C. in remote villages in Cambodia and the Philippines, diminishing the potential efficacy of the tests (Jorgensen et al., Malaria rapid diagnostic tests in tropical climates: The need for a cool chain, Am. J. Trop. Med. Hyg. (2006) 74:750-754, which is herein incorporated by reference). Similar issues regarding storage of malaria rapid diagnostic tests exist in remote and resource-limited areas in Africa (see, e.g., Moonasar et al., An exploratory study of factors that affect the performance and usage of rapid diagnostic tests for malaria in the Limpopo Province, South Africa, Malaria J. (2007) 6:74, which is herein incorporated by reference). As such, a medicinal storage container may be used to maintain a rapid diagnostic test in a temperature range of 2° C. to 30° C. from manufacture in or out of country to an end-user in a remote village, for example. A single rapid diagnostic test may be enclosed in an integrally thermally sealed medicinal storage container for testing a single individual, for example. Alternatively, multiple rapid diagnostic tests may be enclosed in an integrally thermally sealed medicinal storage container for testing multiple individuals on a given day or over a few days. Multiple rapid diagnostic tests may be optionally enclosed in a medicinal storage container with an inner assembly and as such a single unit or multiple units may be dispensed over time without compromising the temperature of the remaining units.

Example 9

In some instances, it may be appropriate to maintain a medical treatment at an elevated temperature. For example, a medicinal storage container may be used to maintain fluids intended for intravenous (IV) administration at or slightly above body temperature (generally 98.6° F./37° C.). In a medical or surgical setting, for example, a medicinal storage container may be used to hold artificial plasma or other blood product at appropriate temperature for immediate use. For example, plasma substitutes such as hydroxylethyl starch (HES) are often administered rapidly to patients with hypovolemia and for hemodilutional autotransfusion (HAT) during surgery and anesthesia (Yamakage et al. Safety and beneficial effect on body core temperature of prewarmed plasma substitute hydroxyethyl starch during anesthesia Anesthesiology (2004) 101:A1285, which is herein incorporated by reference). Addition of these agents at room temperature may result in a drop in the patient's core temperature and as such are best administered at or slightly above body temperature. HES has been shown to be stable at 40° C. for at least 3 months. As such, a blood product such as HES, for example, may be stored at 40° C. in an integrally thermally sealed medicinal storage container. The blood product may be packaged directly into the integrally thermally sealed medicinal storage container. Alternatively, the blood product may be packaged separately in an IV bag ranging in size, for example, from 50 to 1000 milliliters and stored in an integrally thermally sealed medicinal storage container. Optionally, multiple units of prepackaged blood product may be stored in a medicinal storage container with an inner assembly and as such a single unit or multiple units may be dispensed over time without compromising the temperature of the remaining stored units. In some instances, a blood product may be directly packaged in a medicinal storage container with an access region, as described herein.

Example 10

A medicinal storage container may also be used to maintain units of an intravenous (IV) fluid at or slightly above body temperature. For example, a medicinal storage container may hold one or more units of an IV fluid containing dextrose or saline for use, for example, in treating dehydration associated with hypothermia. As the core temperature of a hypothermic individual may already be below normal, administration of intravenous fluids should optimally be performed at body temperature to prevent further cooling (Department of Health & Social Services, State of Alaska, Cold Injuries Guidelines Revised version 2005, which is herein incorporated by reference). As such, a medicinal storage container may contain varying units of prewarmed rehydration fluid. For example, a medicinal storage container with an inner assembly including one or more interlocks and containing prewarmed rehydration solution may be used by first responders in the field such as, for example, a paramedic, an emergency medical technician, search and rescue, coast guard, or military personnel.

Example 11

A medicinal storage container with direct access under pressure may be used to maintain humidified air or oxygen in the range of 43-45° C. (107-122° F.), for example. In a hypothermic individual, loss of heat during respiration may account for 10% to 30% of the body's heat loss, particularly under conditions in which the ambient air temperature is cold. As such, inhalation of warm, water-saturated air is a non-invasive treatment suitable for active core rewarming in the field and donates heat directly to the head, neck, and thoracic core, warming the hypothalamus, the temperature regulation center, the respiratory center, and the cardiac center at the base of the brainstem. (Department of Health & Social Services, State of Alaska, Cold Injuries Guidelines Revised version 2005, which is herein incorporated by reference). In many cases, this rewarming of the central nervous system at the brainstem reverses the cold-induced depression of the respiratory centers and improves the level of consciousness. Alternatively, a medicinal storage container with an access region may contain water ranging in temperature, for example, from 99 to 212° F. (37-100° C.) that may be used in conjunction with a face mask to provide prewarmed, humidified air to a hypothermic individual. For example, inhaled ambient air may be passed over steaming, prewarmed water prior to entering an individual's lungs. As such, a temperature stabilized storage container with an access region may dispense a unit of prewarmed water to an external vessel attached to the breathing apparatus.
While various aspects and embodiments have been disclosed herein, other aspects and embodiments will be apparent to those skilled in the art. The various aspects and embodiments disclosed herein are for purposes of illustration and are not intended to be limiting, with the true scope and spirit being indicated by the following claims.

Claims

What is claimed is:

1.-50. (canceled)

51. A medicinal storage container, comprising:

at least one medicinal storage structure, including:

one or more segments of an ultra efficient insulation material shaped to define at least one substantially temperature-stabilized medicinal storage region, wherein the medicinal storage region is substantially temperature-stabilized between approximately 2° Centigrade and approximately 8° Centigrade; and

at least one access region, including:

at least one region of the one or more segments of an ultra efficient insulation material configured for at least one perforation by at least one perforation device, wherein one or more of the at least one perforation is configured to provide for a controlled egress of a quantity of a medicinal material from the at least one substantially temperature-stabilized medicinal storage region.

52. The medicinal storage container of claim 51, wherein the at least one medicinal storage structure includes no active cooling units.

53. The medicinal storage container of claim 51, comprising:

one or more heat sink units thermally coupled to one or more of the at least one substantially temperature-stabilized medicinal storage region.

54. The medicinal storage container of claim 53, wherein at least one of the one or more heat sink units is removable.

55. The medicinal storage container of claim 53, wherein at least one of the one or more heat sink units is rechargeable.

56. The medicinal storage container of claim 53, wherein there are a plurality of substantially temperature-stabilized medicinal storage regions within the container.

57. The medicinal storage container of claim 51, wherein the ultra efficient insulation material includes:

at least one superinsulation material.

58. The medicinal storage container of claim 51, wherein the ultra efficient insulation material includes:

at least one multilayer insulation material.

59. The medicinal storage container of claim 51, wherein the ultra efficient insulation material includes:

at least two layers of thermal reflective material separated from each other by magnetic suspension.

60.-61. (canceled)

62. The medicinal storage container of claim 51, wherein the at least one access region includes an elongated thermal pathway.

63. The medicinal storage container of claim 51, wherein the at least one access region includes:

at least one substantially tubular structure, wherein the at least one substantially tubular structure is of a size and shape to provide for a controlled egress of a quantity of a medicinal material from the at least one substantially temperature-stabilized medicinal storage region.

64. The medicinal storage container of claim 63, wherein the at least one substantially tubular structure includes at least one hypodermic syringe.

65. The medicinal storage container of claim 63, wherein one or more of the at least one substantially tubular structure are located external to the container, and may be transiently inserted from an exterior of the container to an interior of the container to provide for a controlled egress of a quantity of a medicinal material from the at least one storage region.

66. The medicinal storage container of claim 63, wherein one or more of the at least one substantially tubular structure are located internal to the container, and may be transiently inserted from an interior of the container to an exterior of the container to provide for a controlled egress of a quantity of a medicinal material from the at least one substantially temperature-stabilized medicinal storage region.

67. The medicinal storage container of claim 51, comprising:

a coupling mechanism, wherein the coupling mechanism may create a coupled unit between at least one perforation device internal to the container and at least one perforation device external to the container, thereby creating an egress mechanism for medicinal material from the at least one substantially temperature-stabilized medicinal storage region.

68. The medicinal storage container of claim 51, comprising:

at least one thermally-insulated cover, wherein the at least one thermally insulated cover includes a sealing portion positioned for mating to the at least one access region.

69. The medicinal storage container of claim 51, comprising:

at least one marking on an exterior of the container indicating the at least one access region.

70. The medicinal storage container of claim 51, comprising:

at least one framework attached to an exterior of the container identifying one or more of the at least one region of the one or more segments of an ultra efficient insulation material configured for at least one perforation by a perforation device.

71. The medicinal storage container of claim 51, comprising:

at least one external wall of the container; and

at least one internal wall of the container, wherein one or more of the at least one exterior wall and one or more of the at least one interior wall are movable relative to each other, and the relative movement of one or more of the at least one exterior wall to one or more of the at least one interior wall alters the accessability of one or more of the at least one region of the one or more segments of an ultra efficient insulation material configured for at least one perforation by at least one perforation device.

72. The medicinal storage container of claim 51, comprising:

at least one layer of nontoxic material on an interior surface of one or more of the at least one substantially temperature-stabilized medicinal storage region.

73. The medicinal storage container of claim 51, comprising:

at least one layer of material including at least one metal on an interior surface of one or more of the at least one substantially temperature-stabilized medicinal storage region.

74. The medicinal storage container of claim 73, wherein the at least one layer of material including at least one metal includes silver.

75. The medicinal storage container of claim 51, comprising:

one or more removable inserts within one or more of the at least one substantially temperature-stabilized medicinal storage region.

76. The medicinal storage container of claim 51, comprising:

one or more temperature indicators.

77. The medicinal storage container of claim 51, comprising:

one or more sensors.

78. The medicinal storage container of claim 77, wherein the one or more sensors includes at least one:

sensor of a gaseous pressure within one or more of the at least one storage region, sensor of a mass within one or more of the at least one storage region, sensor of a stored volume within one or more of the at least one storage region, or sensor of an identity of an item within one or more of the at least one storage region.

79. The medicinal storage container of claim 51, comprising:

one or more communications devices.

80. The medicinal storage container of claim 79, wherein the one or more communications devices includes at least one:

one or more recording devices, one or more transmission devices, one or more display devices, or one or more receivers.

81. The medicinal storage container of claim 51, comprising:

at least one compartment within the at least one substantially temperature-stabilized medicinal storage region that is at a higher gaseous pressure than an atmospheric pressure exterior to the container.

82. The medicinal storage container of claim 51, comprising:

at least one operable attachment to a medicinal dispensing device.

83. The medicinal storage container of claim 51, comprising:

an ingress region, including:

at least one region of the one or more segments of an ultra efficient insulation material which may be displaced to allow for at least one transient insertion of an ingress structure from an exterior of the container to an interior of the at least one substantially temperature-stabilized medicinal storage region.

84. The medicinal storage container of claim 83, wherein the at least one access region includes the ingress region.

85. A medicinal storage container, comprising:

at least one medicinal storage structure, including:

one or more segments of an ultra efficient insulation material shaped to define at least one substantially temperature-stabilized medicinal storage region including one or more medicinal units stored between approximately 2° Centigrade and approximately 8° Centigrade; and

at least one access region, including:

86. A medicinal storage container, comprising:

at least one medicinal storage structure, including:

one or more segments of an ultra efficient insulation material shaped to define at least one substantially temperature-stabilized medicinal storage region, wherein the medicinal storage region is substantially temperature-stabilized to ensure maximum stability and efficacy of the stored medicinal material at the time of use or administration; and

at least one access region, including: