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US20130029914A1 - Sebum secretion-blocking composition, and food or beverage containing same - Google Patents

Sebum secretion-blocking composition, and food or beverage containing same Download PDF

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Publication number
US20130029914A1
US20130029914A1 US13/519,581 US201013519581A US2013029914A1 US 20130029914 A1 US20130029914 A1 US 20130029914A1 US 201013519581 A US201013519581 A US 201013519581A US 2013029914 A1 US2013029914 A1 US 2013029914A1
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Prior art keywords
parts
weight
collagen
sebum
sebum secretion
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Abandoned
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US13/519,581
Inventor
Masanori Ito
Masayuki Yugi
Katsumasa Shimizu
Chiharu Takamatsu
Eriko Otani
Takaya Hashizume
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Lotte Co Ltd
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Lotte Co Ltd
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Assigned to LOTTE CO., LTD. reassignment LOTTE CO., LTD. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: HASHIZUME, TAKAYA, ITO, MASANORI, OTANI, ERIKO, SHIMIZU, KATSUMASA, TAKAMATSU, CHIHARU, YUGI, MASAYUKI
Publication of US20130029914A1 publication Critical patent/US20130029914A1/en
Abandoned legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G1/00—Cocoa; Cocoa products, e.g. chocolate; Substitutes therefor
    • A23G1/30—Cocoa products, e.g. chocolate; Substitutes therefor
    • A23G1/32—Cocoa products, e.g. chocolate; Substitutes therefor characterised by the composition containing organic or inorganic compounds
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G1/00—Cocoa; Cocoa products, e.g. chocolate; Substitutes therefor
    • A23G1/30—Cocoa products, e.g. chocolate; Substitutes therefor
    • A23G1/32—Cocoa products, e.g. chocolate; Substitutes therefor characterised by the composition containing organic or inorganic compounds
    • A23G1/44—Cocoa products, e.g. chocolate; Substitutes therefor characterised by the composition containing organic or inorganic compounds containing peptides or proteins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
    • A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
    • A23G3/36—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
    • A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
    • A23G3/36—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds
    • A23G3/44—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds containing peptides or proteins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G4/00—Chewing gum
    • A23G4/06—Chewing gum characterised by the composition containing organic or inorganic compounds
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G4/00—Chewing gum
    • A23G4/06—Chewing gum characterised by the composition containing organic or inorganic compounds
    • A23G4/14—Chewing gum characterised by the composition containing organic or inorganic compounds containing peptides or proteins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G9/00—Frozen sweets, e.g. ice confectionery, ice-cream; Mixtures therefor
    • A23G9/32—Frozen sweets, e.g. ice confectionery, ice-cream; Mixtures therefor characterised by the composition containing organic or inorganic compounds
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G9/00—Frozen sweets, e.g. ice confectionery, ice-cream; Mixtures therefor
    • A23G9/32—Frozen sweets, e.g. ice confectionery, ice-cream; Mixtures therefor characterised by the composition containing organic or inorganic compounds
    • A23G9/38—Frozen sweets, e.g. ice confectionery, ice-cream; Mixtures therefor characterised by the composition containing organic or inorganic compounds containing peptides or proteins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
    • A23J3/00—Working-up of proteins for foodstuffs
    • A23J3/30—Working-up of proteins for foodstuffs by hydrolysis
    • A23J3/32—Working-up of proteins for foodstuffs by hydrolysis using chemical agents
    • A23J3/34—Working-up of proteins for foodstuffs by hydrolysis using chemical agents using enzymes
    • A23J3/341—Working-up of proteins for foodstuffs by hydrolysis using chemical agents using enzymes of animal proteins
    • A23J3/342—Working-up of proteins for foodstuffs by hydrolysis using chemical agents using enzymes of animal proteins of collagen; of gelatin
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Preparation or treatment thereof
    • A23L2/52—Adding ingredients
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Preparation or treatment thereof
    • A23L2/52—Adding ingredients
    • A23L2/66—Proteins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/18—Peptides; Protein hydrolysates
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/20—Reducing nutritive value; Dietetic products with reduced nutritive value
    • A23L33/21—Addition of substantially indigestible substances, e.g. dietary fibres
    • A23L33/28—Substances of animal origin, e.g. gelatin or collagen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/01—Hydrolysed proteins; Derivatives thereof
    • A61K38/012—Hydrolysed proteins; Derivatives thereof from animals
    • A61K38/014—Hydrolysed proteins; Derivatives thereof from animals from connective tissue peptides, e.g. gelatin, collagen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/08—Antiseborrheics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Definitions

  • the present invention relates to a sebum secretion inhibitor (blocker) and a food or drink product and a composition using the same.
  • Sebum refers to lipid found in the human epidermis and is a mixture of a sebaceous secretion and the lipids derived from the epidermis, comprising triglycerides, fatty acids, wax esters, etc. In the human epidermis, 0.05 to 0.4 mg/cm 2 of sebum is considered to be always present. Sebum moisturizes and softens the stratum corneum and also prevents external harmful substances and bacteria from invading and prevents substances such as water from being released out of the body. The amount of sebum varies depending on sites of the body, age, sex, the season, temperature, fat intake, etc. Generally, in humans, the sebum amount is known to be greater in mens than in women, and is further abundant in fetuses and newborns, adolescents, and middle-aged to elderly men.
  • the sebum amount is an important factor to determine the skin type.
  • the skin with a large amount of sebum is classified as oily skin, whereas the skin with a small amount of sebum is classified as not oily skin.
  • the skin becomes greasy, which gives an unpleasant feeling not only to the person him or herself but also to others.
  • sebum amount is excessive, sebum accumulates together with the stratum corneum inside the pores and may induce acnes.
  • the orally administrable sebum secretion inhibitor is desirably comprising ingredients derived from food products or natural products to assure safety.
  • the present invention provides a sebum secretion inhibitor comprising a collagen degradation product.
  • Patent Literature 1 discloses a composition for fine skin and a hair growth formula containing as an active ingredient a polar solvent extract of kiwi fruit seeds.
  • Patent Literature 1 does not mention the relationship between the active ingredient and the sebum secretion inhibition.
  • Patent Literature 2 discloses a preventive and therapeutic composition for psilosis and seborrheic skin diseases containing the extract of kiwi fruit.
  • Patent Literature 2 mainly describes inhibition of psilosis and does not discuss the sebum secretion inhibitory effect in detail.
  • Patent Literature 3 discloses a composition for fine skin containing ingredients such as collagen, hyaluronic acid, etc., obtained by digesting skin of birds, etc., with protease, or the like.
  • Patent Literature 4 discloses an orally administrable composition for promoting fine skin comprising collagen, and the like, and other substances.
  • Patent Literature 5 discloses a composition containing a collagen hydrolysate.
  • An object is to provide a sebum secretion inhibitor and a food or drink product and a composition using the same.
  • the present inventors have conducted extensive studies and consequently found that the sebum secretion is inhibited by orally ingesting a collagen peptide, which is hydrolyzed collagen, whereby the present invention has been accomplished. More specifically, the present invention provides an oral sebum secretion inhibiting composition comprising a collagen hydrolysate and a food or drink product containing the composition.
  • Collagen accounts for high percentage in the total protein in vivo in the mammals and can be obtained at a low cost. Collagen is also a raw material for a gelatin and glue and has long been used as a food material. Collagen is further ingested in everyday life from a meat stew, etc., and thus its safety is widely acknowledged.
  • the sebum secretion inhibitor of the present invention provides the significant sebum secretion inhibitory effect in a short period of time.
  • FIG. 1 is a graph showing the sebum amounts of the subjects before, during and after the ingestion of the powder test meal.
  • the orally administrable sebum secretion inhibiting composition comprising a collagen hydrolysate of the present invention and the food or drink product containing the composition are described.
  • Collagen is a main protein component constituting connective tissue in animals and is characterized by having a collagen triple helical structure.
  • a total of not less than 30 types of collagen have been reported which are respectively termed Type I, Type II, and so on.
  • Type I collagen is the primary component of the derma, ligaments, tendons, bones and the like; and Type II collagen is the primary component of articular cartilage.
  • Type IV collagen is mainly contained in a basal membrane, which is the undercoat of all epithelial tissues.
  • Type I collagen is the most abundant collagen in the body.
  • the collagen origin is not limited, and usable are those derived from mammals such as cow, pig, etc., birds such as chicken, ostrich, etc., fishes such as sharks, etc. Those derived from livestock such as cow, pig, chicken, etc., are easily obtainable in a large amount, hence particularly preferable.
  • the type of collagen is not limited and any type can be used, or a plurality of collagen types may be used in mixture.
  • the collagen hydrolysate refers to a low molecular collagen obtained by hydrolyzing collagen with an acid, alkali or enzyme.
  • a collagen hydrolysate can be obtained by immersing skins and joints of animals such as pig, cow and chicken or scales and skins of fish in an acid or alkali solution to extract gelatin and treating the extracted gelatin with an enzyme or acid.
  • the gelatin refers to the collagen pre-treated with an acid or alkali and then solubilized by heat hydrolysis.
  • the sebum secretion inhibiting composition of the present invention is for oral administration, but the dosage form is not limited and can be administered in the form of, for example, tablets, capsules, drinks, etc. Further, the sebum secretion inhibiting composition of the present invention may be administered by being contained in a food or drink product, and, in that case, the food or drink product in which the composition is contained are not limited, and examples include carbonated drinks, nutritional drinks, liquors, sweets, nutritional food products, frozen sweets, dairy products, meats, etc., and food products as a raw material to be used for these products.
  • the sebum secretion inhibiting composition of the present invention refers to a composition which inhibits sebum secreted from skin and the skin may be derived from any site of the body, but face, head, chest, back, armpits, genital area, etc., known as the areas where sebaceous glands are dense have abundant sebum secretion, hence are included as target sites.
  • the collagen hydrolysate a commercial “Collagen Peptide” (pig) having a molecular weight of 20000 or less was used.
  • the collagen peptide used was obtained by immersing the pig skin in an acid or alkali solution to extract gelatin and further enzymolyzing the extracted gelatin.
  • the collagen peptide is mainly derived from pig Type I collagen.
  • a powder test meal comprising the composition shown in Table 1 was prepared.
  • the powder test meal contains 10000 mg of collagen peptide and 100 mg of vitamin C per meal. Vitamin C is added because it is required to synthesize collagen in vivo.
  • the value (arbitrary unit a.u.) indicated as an oil content measurement value by the measurement apparatus was referred to as the sebum value.
  • 10 of the subjects had a sebum amount of 40 a.u. or more, whereas 6 subjects had a sebum amount of below 40 a.u.
  • These groups were termed as the preingestion sebum amount ⁇ the 40-group and the preingestion sebum amount ⁇ the 40-group, respectively.
  • Table 2 shows the average value of the sebum amount of all subjects, the average value of the sebum amount of the preingestion sebum amount ⁇ the 40-group and the average value of the sebum amount of the preingestion sebum amount ⁇ the 40-group before ingesting the powder test meal, 1 week and 2 weeks after the start of ingestion and 1 week after the completion of ingestion.
  • ⁇ represents the average value for all subjects
  • ⁇ represents the average value of the sebum amount of the preingestion sebum amount ⁇ the 40-group
  • ⁇ represents the average value of the sebum amount of the preingestion sebum amount ⁇ the 40-group.
  • the sebum secretion inhibitory effect was significant in the preingestion sebum amount ⁇ the 40-group which leads to the presumption that people with oily skin inherently are most likely to benefit the effect.
  • the effect already started showing within 1 week after the ingestion and the sebum amount increased again 1 week later from the ingestion which leads to the presumption that the effect can be attained in a comparatively short period of time.
  • a drink, a powder, a tablet, a chewing gum, a candy, a tablet candy, a gummy jelly, a chocolate and a sorbet were produced with the following formula.
  • Collagen peptide 5.0 parts by weight High fructose corn syrup 8.0 parts by weight Sugar 4.0 parts by weight Flavor 0.5 parts by weight Vitamin C 0.5 parts by weight After adjusting pH to 3.8 using an acidifier, the drink was prepared to be 100 parts by volume with purified water.
  • Collagen peptide 5.0 parts by weight Sucralose 0.005 parts by weight Stevioside 0.008 parts by weight Rebaudioside 0.008 parts by weight Acesulfame potassium 0.01 parts by weight Peach flavor 0.5 parts by weight Vitamin C 0.5 parts by weight After adjusting pH to 3.8 using an acidifier, the drink was prepared to be 100 parts by volume with purified water.
  • Collagen peptide 5.0 parts by weight Acidic lactic beverage 5.0 parts by weight High fructose corn syrup 10.0 parts by weight Flavor 0.5 parts by weight Vitamin C 0.5 parts by weight After adjusting pH to 3.8 using an acidifier, the drink was prepared to be 100 parts by volume with purified water.
  • Collagen peptide 5.0 parts by weight High fructose corn syrup 10.0 parts by weight Honey 5.0 parts by weight Flavor 0.5 parts by weight Vitamin C 0.5 parts by weight After adjusting pH to 3.8 using an acidifier, the drink was prepared to be 100 parts by volume with purified water.
  • Collagen peptide 5.0 parts by weight Sucralose 0.005 parts by weight Stevioside 0.008 parts by weight Rebaudioside 0.008 parts by weight Acesulfame potassium 0.01 parts by weight Peach flavor 0.5 parts by weight Vitamin C 0.5 parts by weight Gelation stabilizer 0.5 parts by weight After adjusting pH to 3.8 using an acidifier, the drink was prepared to be 100 parts by volume with purified water.
  • Collagen peptide 5.0 parts by weight High fructose corn syrup 8.0 parts by weight Sugar 4.0 parts by weight Flavor 0.5 parts by weight Vitamin C 0.5 parts by weight Gelation stabilizer 0.5 parts by weight After adjusting pH to 3.8 using an acidifier, the drink was prepared to be 100 parts by volume with purified water.
  • Collagen peptide 5.0 parts by weight Coffee extract 5.0 parts by weight Sugar 4.0 parts by weight Flavor 0.5 parts by weight Vitamin C 0.5 parts by weight After adjusting pH to 6.5 using sodium bicarbonate, the drink was prepared to be 100 parts by volume with purified water.
  • Collagen peptide 5.0 parts by weight Green tea extract 10.0 parts by weight Flavor 0.5 parts by weight Vitamin C 0.5 parts by weight After adjusting pH to 6.5 using sodium bicarbonate, the drink was prepared to be 100 parts by volume with purified water.
  • Collagen peptide 5.0 parts by weight Gum base 20.0 parts by weight Sugar 55.0 parts by weight Glucose 10.5 parts by weight Starch syrup 9.0 parts by weight Vitamin C 0.05 parts by weight Flavor 0.5 parts by weight
  • Collagen peptide 5.0 parts by weight Sugar 50.0 parts by weight Starch syrup 29.5 parts by weight Flavor 0.5 parts by weight Vitamin C 0.05 parts by weight Water 15.0 parts by weight
  • Collagen peptide 5.0 parts by weight Sugar 73.5 parts by weight Glucose 17.0 parts by weight Sucrose esters of fatty acids 0.2 parts by weight Flavor 0.2 parts by weight Vitamin C 0.05 parts by weight Water 4.1 parts by weight
  • Collagen peptide 5.0 parts by weight Gelatin 55.0 parts by weight Starch syrup 23.0 parts by weight Sugar 8.5 parts by weight Vegetable oil and fat 4.5 parts by weight Mannitol 3.0 parts by weight Vitamin C 0.05 parts by weight Lemon juice 1.0 parts by weight
  • Collagen peptide 5.0 parts by weight Powder sugar 36.8 parts by weight Cacao bitter 20.0 parts by weight Whole milk powder 20.0 parts by weight Cacao butter 17.0 parts by weight Mannitol 1.0 parts by weight Vitamin C 0.05 parts by weight Flavor 0.2 parts by weight
  • Collagen peptide 5.0 parts by weight Orange juice 25.0 parts by weight Sugar 23.0 parts by weight Egg white 9.0 parts by weight Vitamin C 0.05 parts by weight Water 38.0 parts by weight

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Abstract

An object is to provide a sebum secretion inhibiting composition and a food or drink product using the same. The present inventors have conducted extensive studies and consequently found that the sebum secretion is inhibited by orally ingesting a collagen peptide, which is hydrolyzed collagen, and provide an oral sebum secretion inhibiting composition comprising a collagen hydrolysate and a food or drink product containing the composition.

Description

    TECHNICAL FIELD
  • The present invention relates to a sebum secretion inhibitor (blocker) and a food or drink product and a composition using the same.
    • BACKGROUND ART
  • Sebum refers to lipid found in the human epidermis and is a mixture of a sebaceous secretion and the lipids derived from the epidermis, comprising triglycerides, fatty acids, wax esters, etc. In the human epidermis, 0.05 to 0.4 mg/cm2 of sebum is considered to be always present. Sebum moisturizes and softens the stratum corneum and also prevents external harmful substances and bacteria from invading and prevents substances such as water from being released out of the body. The amount of sebum varies depending on sites of the body, age, sex, the season, temperature, fat intake, etc. Generally, in humans, the sebum amount is known to be greater in mens than in women, and is further abundant in fetuses and newborns, adolescents, and middle-aged to elderly men.
  • The sebum amount is an important factor to determine the skin type. The skin with a large amount of sebum is classified as oily skin, whereas the skin with a small amount of sebum is classified as not oily skin. When the oiliness increases, the skin becomes greasy, which gives an unpleasant feeling not only to the person him or herself but also to others. Also, when a sebum amount is excessive, sebum accumulates together with the stratum corneum inside the pores and may induce acnes.
  • Accordingly, there is a need for a sebum secretion inhibitor which inhibits the sebum secretion. Although there are a variety of topical sebum secretion inhibitors, inhibition by an external medicine often fails to provide a fundamental solution, and there is a need for an orally administrable sebum secretion inhibitor. The orally administrable sebum secretion inhibitor is desirably comprising ingredients derived from food products or natural products to assure safety. Thus, the present invention provides a sebum secretion inhibitor comprising a collagen degradation product.
  • The following products are reported as orally administrable compositions for fine skin comprising food products or ingredients derived from natural products. Patent Literature 1 discloses a composition for fine skin and a hair growth formula containing as an active ingredient a polar solvent extract of kiwi fruit seeds. However, Patent Literature 1 does not mention the relationship between the active ingredient and the sebum secretion inhibition. Further, Patent Literature 2 discloses a preventive and therapeutic composition for psilosis and seborrheic skin diseases containing the extract of kiwi fruit. However, Patent Literature 2 mainly describes inhibition of psilosis and does not discuss the sebum secretion inhibitory effect in detail.
  • The following compositions are reported as orally administrable compositions for fine skin associated with collagen or degradation products thereof. More specifically, Patent Literature 3 discloses a composition for fine skin containing ingredients such as collagen, hyaluronic acid, etc., obtained by digesting skin of birds, etc., with protease, or the like. Patent Literature 4 discloses an orally administrable composition for promoting fine skin comprising collagen, and the like, and other substances. Patent Literature 5 discloses a composition containing a collagen hydrolysate. However, none of these literatures suggests or discloses the relation between collagen or a collagen degradation product and the sebum secretion inhibition.
    • CITATION LIST Patent Literature
    • PTL 1: Japanese Patent Application Laid-Open No. 2007-99751
    • PTL 2: Japanese National Publication of International Patent Application No. 2008-509905
    • PTL 3: Japanese Patent Application Laid-Open No. H11-308977
    • PTL 4: Japanese Patent Application Laid-Open No. 2007-320891
    • PTL 5: Japanese Patent Application Laid-Open No. 2008-194010
    SUMMARY OF INVENTION Technical Problem
  • An object is to provide a sebum secretion inhibitor and a food or drink product and a composition using the same.
    • Solution to Problem
  • The present inventors have conducted extensive studies and consequently found that the sebum secretion is inhibited by orally ingesting a collagen peptide, which is hydrolyzed collagen, whereby the present invention has been accomplished. More specifically, the present invention provides an oral sebum secretion inhibiting composition comprising a collagen hydrolysate and a food or drink product containing the composition.
    • Advantageous Effects of Invention
  • Collagen accounts for high percentage in the total protein in vivo in the mammals and can be obtained at a low cost. Collagen is also a raw material for a gelatin and glue and has long been used as a food material. Collagen is further ingested in everyday life from a meat stew, etc., and thus its safety is widely acknowledged.
  • Furthermore, the sebum secretion inhibitor of the present invention provides the significant sebum secretion inhibitory effect in a short period of time.
    • BRIEF DESCRIPTION OF DRAWINGS
  • FIG. 1 is a graph showing the sebum amounts of the subjects before, during and after the ingestion of the powder test meal.
    •  DESCRIPTION OF EMBODIMENTS
  • Hereinafter, the orally administrable sebum secretion inhibiting composition comprising a collagen hydrolysate of the present invention and the food or drink product containing the composition are described.
  • Collagen is a main protein component constituting connective tissue in animals and is characterized by having a collagen triple helical structure. A total of not less than 30 types of collagen have been reported which are respectively termed Type I, Type II, and so on. Type I collagen is the primary component of the derma, ligaments, tendons, bones and the like; and Type II collagen is the primary component of articular cartilage. Further, Type IV collagen is mainly contained in a basal membrane, which is the undercoat of all epithelial tissues. Type I collagen is the most abundant collagen in the body.
  • In the sebum secretion inhibiting composition of the present invention, the collagen origin is not limited, and usable are those derived from mammals such as cow, pig, etc., birds such as chicken, ostrich, etc., fishes such as sharks, etc. Those derived from livestock such as cow, pig, chicken, etc., are easily obtainable in a large amount, hence particularly preferable. Further, the type of collagen is not limited and any type can be used, or a plurality of collagen types may be used in mixture.
  • In the present invention, the collagen hydrolysate (hereinafter sometimes referred to as collagen peptide) refers to a low molecular collagen obtained by hydrolyzing collagen with an acid, alkali or enzyme. For example, a collagen hydrolysate can be obtained by immersing skins and joints of animals such as pig, cow and chicken or scales and skins of fish in an acid or alkali solution to extract gelatin and treating the extracted gelatin with an enzyme or acid. The gelatin refers to the collagen pre-treated with an acid or alkali and then solubilized by heat hydrolysis.
  • The sebum secretion inhibiting composition of the present invention is for oral administration, but the dosage form is not limited and can be administered in the form of, for example, tablets, capsules, drinks, etc. Further, the sebum secretion inhibiting composition of the present invention may be administered by being contained in a food or drink product, and, in that case, the food or drink product in which the composition is contained are not limited, and examples include carbonated drinks, nutritional drinks, liquors, sweets, nutritional food products, frozen sweets, dairy products, meats, etc., and food products as a raw material to be used for these products.
  • The sebum secretion inhibiting composition of the present invention refers to a composition which inhibits sebum secreted from skin and the skin may be derived from any site of the body, but face, head, chest, back, armpits, genital area, etc., known as the areas where sebaceous glands are dense have abundant sebum secretion, hence are included as target sites.
    • EXAMPLE
  • Hereinafter, the present invention will be described in detail with reference to Examples. However, the present invention is not limited to the following Examples.
    • Example 1
  • For the collagen hydrolysate, a commercial “Collagen Peptide” (pig) having a molecular weight of 20000 or less was used. The collagen peptide used was obtained by immersing the pig skin in an acid or alkali solution to extract gelatin and further enzymolyzing the extracted gelatin. The collagen peptide is mainly derived from pig Type I collagen.
  • For the test meal containing the collagen peptide, a powder test meal comprising the composition shown in Table 1 was prepared. The powder test meal contains 10000 mg of collagen peptide and 100 mg of vitamin C per meal. Vitamin C is added because it is required to synthesize collagen in vivo.
  • TABLE 1
    Ingredient name g/meal
    Collagen peptide 10.0
    Excipient, sweetener 1.7
    Flavor 0.2
    Vitamin C 0.1
    Total 12.0
  • Sixteen men in their twenties and thirties as the subjects orally ingested the powder test meal. The subjects took one meal of the powder test meal added to milk, juice, miso soup or the like at any convenient time once a day for 12 consecutive days. The sebum amount of the subjects was measured before, during and after the ingestion of the powder test meal. On the measurement day, the subjects washed their faces with warm water and a facial soap at 1 p.m., and 2 hours later, i.e., around 3 p.m., the measurement was carried out. The measurement was carried out, using an optical sebum measurement apparatus, Triplesense (Moritex Precision Corporation), by pressing the sensor part of the measurement apparatus against a spot about 3 cm below the eye on the face of the subject. The value (arbitrary unit a.u.) indicated as an oil content measurement value by the measurement apparatus was referred to as the sebum value. Before ingesting the powder test meal, 10 of the subjects had a sebum amount of 40 a.u. or more, whereas 6 subjects had a sebum amount of below 40 a.u. These groups were termed as the preingestion sebum amount≧the 40-group and the preingestion sebum amount<the 40-group, respectively. Table 2 shows the average value of the sebum amount of all subjects, the average value of the sebum amount of the preingestion sebum amount≧the 40-group and the average value of the sebum amount of the preingestion sebum amount<the 40-group before ingesting the powder test meal, 1 week and 2 weeks after the start of ingestion and 1 week after the completion of ingestion. Similarly, the results in the form of graph are shown in FIG. 1. In FIG. 1, Δ represents the average value for all subjects, ∘ represents the average value of the sebum amount of the preingestion sebum amount≧the 40-group, and □ represents the average value of the sebum amount of the preingestion sebum amount<the 40-group.
  • TABLE 2
    Preingestion Week 1 Week 2 Postingestion
    (a.u.) (a.u.) (a.u.) Week 1 (a.u.)
    Overall average 42.6 35.4 36.3 41.3
    Preingestion sebum 52.1 41.9 43.4 47.6
    amount ≧ 40-group
    Preingestion sebum 26.9 24.7 24.4 31.8
    amount < 40-group
  • After ingesting the powder test meal, all groups had reduced sebum amounts in comparison with before ingestion which revealed that the sebum secretion was inhibited owing to the ingestion of the powder test meal. In particular, the sebum secretion inhibitory effect was significant in the preingestion sebum amount≧the 40-group which leads to the presumption that people with oily skin inherently are most likely to benefit the effect. The effect already started showing within 1 week after the ingestion and the sebum amount increased again 1 week later from the ingestion which leads to the presumption that the effect can be attained in a comparatively short period of time.
  • The same test was also carried out for the group which did not ingest the powder test meal but the sebum inhibitory effect was not observed.
  • Examples of application of the deodorized collagen peptide obtained based on the above test results to drink or food products or compositions, are shown below.
  • Using the present product (collagen peptide) prepared by the methods described in Example 1, a drink, a powder, a tablet, a chewing gum, a candy, a tablet candy, a gummy jelly, a chocolate and a sorbet were produced with the following formula.
    • Example 2 Formula for a Drink
  • Collagen peptide 5.0 parts by weight
    High fructose corn syrup 8.0 parts by weight
    Sugar 4.0 parts by weight
    Flavor 0.5 parts by weight
    Vitamin C 0.5 parts by weight

    After adjusting pH to 3.8 using an acidifier, the drink was prepared to be 100 parts by volume with purified water.
    • Example 3 Formula for a Drink
  • Collagen peptide 5.0 parts by weight
    Sucralose 0.005 parts by weight
    Stevioside 0.008 parts by weight
    Rebaudioside 0.008 parts by weight
    Acesulfame potassium 0.01 parts by weight
    Peach flavor 0.5 parts by weight
    Vitamin C 0.5 parts by weight

    After adjusting pH to 3.8 using an acidifier, the drink was prepared to be 100 parts by volume with purified water.
    • Example 4 Formula for a Drink
  • Collagen peptide 5.0 parts by weight
    Acidic lactic beverage 5.0 parts by weight
    High fructose corn syrup 10.0 parts by weight 
    Flavor 0.5 parts by weight
    Vitamin C 0.5 parts by weight

    After adjusting pH to 3.8 using an acidifier, the drink was prepared to be 100 parts by volume with purified water.
    • Example 5 Formula for a Drink
  • Collagen peptide 5.0 parts by weight
    High fructose corn syrup 10.0 parts by weight 
    Honey 5.0 parts by weight
    Flavor 0.5 parts by weight
    Vitamin C 0.5 parts by weight

    After adjusting pH to 3.8 using an acidifier, the drink was prepared to be 100 parts by volume with purified water.
    • Example 6 Formula for a Jelly Drink
  • Collagen peptide 5.0 parts by weight
    Sucralose 0.005 parts by weight
    Stevioside 0.008 parts by weight
    Rebaudioside 0.008 parts by weight
    Acesulfame potassium 0.01 parts by weight
    Peach flavor 0.5 parts by weight
    Vitamin C 0.5 parts by weight
    Gelation stabilizer 0.5 parts by weight

    After adjusting pH to 3.8 using an acidifier, the drink was prepared to be 100 parts by volume with purified water.
    • Example 7 Formula for a Jelly Drink
  • Collagen peptide 5.0 parts by weight
    High fructose corn syrup 8.0 parts by weight
    Sugar 4.0 parts by weight
    Flavor 0.5 parts by weight
    Vitamin C 0.5 parts by weight
    Gelation stabilizer 0.5 parts by weight

    After adjusting pH to 3.8 using an acidifier, the drink was prepared to be 100 parts by volume with purified water.
    • Example 8 Formula for a Coffee Drink
  • Collagen peptide 5.0 parts by weight
    Coffee extract 5.0 parts by weight
    Sugar 4.0 parts by weight
    Flavor 0.5 parts by weight
    Vitamin C 0.5 parts by weight

    After adjusting pH to 6.5 using sodium bicarbonate, the drink was prepared to be 100 parts by volume with purified water.
    • Example 9 Formula for a Green Tea Drink
  • Collagen peptide 5.0 parts by weight
    Green tea extract 10.0 parts by weight 
    Flavor 0.5 parts by weight
    Vitamin C 0.5 parts by weight

    After adjusting pH to 6.5 using sodium bicarbonate, the drink was prepared to be 100 parts by volume with purified water.
    • Example 10 Formula for a Powder
  • Collagen peptide 90.0 parts by weight 
    Lactose 5.0 parts by weight
    Dextrin 4.0 parts by weight
    Vitamin C 0.9 parts by weight
    • Example 11 Formula for a Tablet
  • Collagen peptide 5.0 parts by weight
    D-mannitol 40.0 parts by weight
    Lactose 40.0 parts by weight
    Crystalline cellulose 10.0 parts by weight
    Vitamin C 0.05 parts by weight
    Hydroxypropyl cellulose 5.0 parts by weight
    • Example 12 Formula for a Chewing Gum
  • Collagen peptide 5.0 parts by weight
    Gum base 20.0 parts by weight
    Sugar 55.0 parts by weight
    Glucose 10.5 parts by weight
    Starch syrup 9.0 parts by weight
    Vitamin C 0.05 parts by weight
    Flavor 0.5 parts by weight
    • Example 13 Formula for a Candy
  • Collagen peptide 5.0 parts by weight
    Sugar 50.0 parts by weight
    Starch syrup 29.5 parts by weight
    Flavor 0.5 parts by weight
    Vitamin C 0.05 parts by weight
    Water 15.0 parts by weight
    • Example 14 Formula for a Tablet Candy
  • Collagen peptide 5.0 parts by weight
    Sugar 73.5 parts by weight
    Glucose 17.0 parts by weight
    Sucrose esters of fatty acids 0.2 parts by weight
    Flavor 0.2 parts by weight
    Vitamin C 0.05 parts by weight
    Water 4.1 parts by weight
    • Example 15 Formula for a Gummy Jelly
  • Collagen peptide 5.0 parts by weight
    Gelatin 55.0 parts by weight
    Starch syrup 23.0 parts by weight
    Sugar 8.5 parts by weight
    Vegetable oil and fat 4.5 parts by weight
    Mannitol 3.0 parts by weight
    Vitamin C 0.05 parts by weight
    Lemon juice 1.0 parts by weight
    • Example 16 Formula for a Chocolate
  • Collagen peptide 5.0 parts by weight
    Powder sugar 36.8 parts by weight
    Cacao bitter 20.0 parts by weight
    Whole milk powder 20.0 parts by weight
    Cacao butter 17.0 parts by weight
    Mannitol 1.0 parts by weight
    Vitamin C 0.05 parts by weight
    Flavor 0.2 parts by weight
    • Example 17 Formula for a Sorbet
  • Collagen peptide 5.0 parts by weight
    Orange juice 25.0 parts by weight
    Sugar 23.0 parts by weight
    Egg white 9.0 parts by weight
    Vitamin C 0.05 parts by weight
    Water 38.0 parts by weight
  • Hereinabove, the present invention has been described with reference to Examples but can be carried out without being limited to these embodiments of the present invention.
  • This application claims the priority to the Japanese Patent Application No. 2009-297848, filed on Dec. 28, 2009, and the contents of which is hereby incorporated by reference as a part of the present application.

Claims (2)

1. An oral sebum secretion inhibiting composition comprising a collagen hydrolysate.
2. A food or drink product containing an oral sebum secretion inhibiting composition according to claim 1.
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10253090B2 (en) 2016-03-22 2019-04-09 Avicenna Nutraceutical, Llc Hydrolyzed collagen compositions and methods of making thereof

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2948003B1 (en) 2013-01-23 2020-03-18 Bottled Science Limited Skin enhancing beverage composition
JP6296792B2 (en) * 2013-12-27 2018-03-20 丸善製薬株式会社 Method for stabilizing quality of beverage composition and beverage composition
JP6338396B2 (en) * 2014-02-21 2018-06-06 新田ゼラチン株式会社 Collagen peptide-containing tea beverage
MX2022010745A (en) * 2020-03-03 2022-11-08 Lonza Greenwood Llc UNDESNATURALIZED TYPE II COLLAGEN IN FOOD AND BEVERAGE APPLICATIONS AND USES THEREOF.
TWI842364B (en) * 2021-08-23 2024-05-11 大陸商廣州市技嘉貿易有限公司 A facial mask containing red grape algae extract for inhibiting sebum secretion
CN115869207A (en) * 2022-12-08 2023-03-31 山东省科学院生物研究所 A composition based on tuna collagen peptide and its application in cosmetics

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050266137A1 (en) * 2003-09-08 2005-12-01 Slim-Fast Foods Company, Division Of Conopco, Inc. Food composition
US20060275345A1 (en) * 2003-08-21 2006-12-07 Gelita Ag Collagen hydrolysate
US20110039767A1 (en) * 2007-07-06 2011-02-17 Arie Gijsbert Nieuwenhuizen Food compositions

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3929740A1 (en) * 1989-09-07 1991-03-14 Hoechst Ag HIGHLY MOLECULAR PROTEIN FATIGUE ACIDICONDUCTIVE PRODUCTS WITH VERY GOOD SKIN AND SWEATBAR CONFIDENTIALITY
JPH03220129A (en) * 1990-01-22 1991-09-27 Shiseido Co Ltd Sebum suppressant
JP3782122B2 (en) * 1994-04-11 2006-06-07 サンスター株式会社 Metabolism promoter for oral intake and food containing the same
JPH11308977A (en) * 1998-04-28 1999-11-09 Ox:Kk Beauty skin cosmetic composition
JP4057163B2 (en) * 1998-09-18 2008-03-05 日本メナード化粧品株式会社 Beauty food
JP2002255847A (en) * 2001-02-26 2002-09-11 Miyagi Kagaku Kogyo Kk Collagen production promoter, functional food and pharmaceutical preparation
US20090226555A1 (en) 2004-08-10 2009-09-10 Helixir Co., Ltd. Extract of actinidia arguta for preventing and treating baldness disorders and seborrheic skin disorders
JP4925692B2 (en) 2005-09-12 2012-05-09 オリザ油化株式会社 Skin care composition
JP2007320891A (en) * 2006-05-31 2007-12-13 Im Press Kk Oral composition for promoting skin beauty
JP2008194010A (en) * 2007-02-15 2008-08-28 Nihon Koken Kk Method for producing collagen peptide-containing composition, and use of the composition
JP2008297241A (en) 2007-05-31 2008-12-11 Fujifilm Corp Acne skin preparations for acne

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060275345A1 (en) * 2003-08-21 2006-12-07 Gelita Ag Collagen hydrolysate
US20050266137A1 (en) * 2003-09-08 2005-12-01 Slim-Fast Foods Company, Division Of Conopco, Inc. Food composition
US20110039767A1 (en) * 2007-07-06 2011-02-17 Arie Gijsbert Nieuwenhuizen Food compositions

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10253090B2 (en) 2016-03-22 2019-04-09 Avicenna Nutraceutical, Llc Hydrolyzed collagen compositions and methods of making thereof
US11028147B2 (en) 2016-03-22 2021-06-08 Avicenna Nutraceutical, Llc Hydrolyzed collagen compositions and methods of making thereof

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