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US20110286573A1 - Method and apparatus for large field of view imaging and detection and compensation of motion artifacts - Google Patents

Method and apparatus for large field of view imaging and detection and compensation of motion artifacts Download PDF

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Publication number
US20110286573A1
US20110286573A1 US13/145,128 US200913145128A US2011286573A1 US 20110286573 A1 US20110286573 A1 US 20110286573A1 US 200913145128 A US200913145128 A US 200913145128A US 2011286573 A1 US2011286573 A1 US 2011286573A1
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motion
projection data
detector
during
image
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Colas Schretter
Matthias Bertram
Christoph Neukirchen
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Koninklijke Philips NV
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Koninklijke Philips Electronics NV
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Publication of US20110286573A1 publication Critical patent/US20110286573A1/en
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    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T11/00—2D [Two Dimensional] image generation
    • G06T11/003—Reconstruction from projections, e.g. tomography
    • G06T11/005—Specific pre-processing for tomographic reconstruction, e.g. calibration, source positioning, rebinning, scatter correction, retrospective gating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/02—Arrangements for diagnosis sequentially in different planes; Stereoscopic radiation diagnosis
    • A61B6/03—Computed tomography [CT]
    • A61B6/032—Transmission computed tomography [CT]
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61B6/40—Arrangements for generating radiation specially adapted for radiation diagnosis
    • A61B6/4064—Arrangements for generating radiation specially adapted for radiation diagnosis specially adapted for producing a particular type of beam
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    • A61B6/4208—Arrangements for detecting radiation specially adapted for radiation diagnosis characterised by using a particular type of detector
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61B6/44—Constructional features of apparatus for radiation diagnosis
    • A61B6/4429—Constructional features of apparatus for radiation diagnosis related to the mounting of source units and detector units
    • A61B6/4452—Constructional features of apparatus for radiation diagnosis related to the mounting of source units and detector units the source unit and the detector unit being able to move relative to each other
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61B6/48—Diagnostic techniques
    • A61B6/488—Diagnostic techniques involving pre-scan acquisition
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/52—Devices using data or image processing specially adapted for radiation diagnosis
    • A61B6/5211—Devices using data or image processing specially adapted for radiation diagnosis involving processing of medical diagnostic data
    • A61B6/5217—Devices using data or image processing specially adapted for radiation diagnosis involving processing of medical diagnostic data extracting a diagnostic or physiological parameter from medical diagnostic data
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/54—Control of apparatus or devices for radiation diagnosis
    • A61B6/542—Control of apparatus or devices for radiation diagnosis involving control of exposure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61B6/58—Testing, adjusting or calibrating thereof
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    • G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/30—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indices; for individual health risk assessment
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Definitions

  • a conventional CT imaging device includes an x-ray source and an x-ray sensitive detector disposed on opposite sides of an examination region.
  • a human patient or other object to be examined is supported in the examination region by a suitable support.
  • the source emits x-ray radiation which transverses the examination region and is detected by the detector as the source and detector rotate about a center of rotation.
  • a CT imaging device capable of having an offset geometry includes an x-ray source and an x-ray sensitive detector that may be transversely displaced from the center of rotation in the transaxial plane in certain configurations. Such offset geometry CT imaging devices are desirable because they allow for an increased field of view or allow for the use of a smaller sized detector.
  • the quality of images obtained from CT imaging devices is also frequently degraded by uncontrolled patient movement, such as the patient's failure to hold his or her breath, intestinal contractions, nervous shaking, natural cyclic motion, heartbeat, respiration, or other forms of motion.
  • iterative algorithmic motion compensation methods are used to improve image quality for images that contain motion artifacts. While such methods are capable of improving image quality for certain types of motion, the motion compensation effects accomplished by these methods are often inaccurate and they also can introduce artifacts into image regions that have not been affected by any motion.
  • a method and apparatus are provided for the detection and compensation of motion artifacts when reconstructing tomographic images.
  • a method and apparatus for creating a motion map is provided. The motion map is utilized to indicate which image regions may be corrupted by motion artifacts and/or for motion compensation to prevent motion artifacts in the reconstructed tomographic image.
  • the invention may take form in various components and arrangements of components, and in various process operations and arrangements of process operations.
  • FIG. 1 is a transaxial view of a centered CT acquisition geometry according to an embodiment of the invention
  • FIG. 2A is a transaxial view of a virtual detector which results from combining the data gathered from the centered geometry of FIG. 1 and the offset geometry of FIG. 2 ;
  • FIG. 3 is an imaging system according to an embodiment of the invention.
  • FIG. 4 depicts an imaging method according to an embodiment of the invention
  • FIG. 5 depicts a method for detecting motion according to an embodiment of the invention
  • FIGS. 6A and 6B depict optional methods for refining a motion map in accordance with an embodiment of the present invention
  • FIG. 7 is exemplary image generated by a software program depicting a motion map in accordance with an embodiment of the present invention.
  • FIG. 8 is an exemplary image generated by a software program depicting a motion-corrupted reconstructed image without any motion correction
  • FIG. 9 is an exemplary image generated by a software program depicting the reconstructed image of FIG. 8 after a global motion correction.
  • FIG. 10 is an exemplary image generated by a software program depicting the reconstructed image of FIG. 8 after a local motion correction.
  • One aspect of the present invention is directed generally to a method and apparatus for CT image acquisition, and more particularly to a method and apparatus for providing a large field of view (“FOV”) with improved image quality by utilizing at least two scanning procedures taken by a CT image apparatus. At least one scan is taken with the radiation source and detector of the CT image apparatus in a centered geometry and at least one scan is taken with the detector and/or source in an offset geometry. The image data obtained from the at least two scanning procedures is then combined to produce a reconstructed image.
  • FOV large field of view
  • FIG. 1 depicts an exemplary centered geometry 100 for a CT imaging apparatus.
  • the exemplary centered geometry 100 has an x-ray source 102 , such as an x-ray tube, and an x-ray sensitive detector 104 , such as a flat panel area detector array extending in the transverse and axial directions.
  • the center of rotation 114 may also serve as the center of the transverse field of view (FOV) 118 .
  • FOV transverse field of view
  • center of rotation 114 is not necessarily always aligned with the center of the transverse FOV 118 in every application.
  • an object support 110 supports the object 108 under examination in an examination region 106 .
  • a central ray or projection 116 of the x-ray beam 112 is perpendicular to the detector center 119 , which is aligned with the center of rotation 114 .
  • the x-ray source 102 and the x-ray sensitive detector 104 rotate about the center of rotation 114 .
  • the source 102 and detector 104 are generally mounted to a rotating gantry (not shown) for rotation about the examination region 106 . In some embodiments, however, the source 102 and detector 104 may remain at a constant angular position while the object 108 is moved and/or rotated to produce the requisite angular sampling. While the figures and description are focused on the use of flat panel detectors, arcuate detectors or detectors having yet other shapes may also be used. Furthermore, while the figures and discussion focus on a CT system in which the source 102 is a point source, other alternatives are contemplated. For example, the source 102 may be a line source. Gamma and other radiation sources may also be used. Multiple sources 102 and detectors 104 may also be provided, in which case corresponding sets of sources and detectors may be offset angularly and/or longitudinally from one another.
  • the x-ray source 102 and detector 104 of the exemplary centered geometry 100 are depicted in two opposing positions in the transaxial plane, position A in solid lines and position B in dotted lines.
  • position B the x-ray source 102 and detector 104 are rotated 180 degrees about the center of rotation 114 from position A.
  • the central ray 116 of the x-ray beam 112 and the detector center 119 are aligned with the center of rotation 114 when the x-ray source 102 and detector 104 are in both position A and position B.
  • FIG. 2 depicts an exemplary offset geometry 200 for an imaging apparatus.
  • the detector center 119 of the detector 104 of the exemplary offset geometry 200 is transversely displaced or offset from the center of rotation 114 in the transaxial plane by a distance D.
  • the x-ray source 102 and the x-ray sensitive detector 104 of the offset geometry 200 rotate about the center of rotation 114 .
  • the x-ray source 102 and detector 104 of the exemplary offset geometry 100 are depicted in two opposing positions in the transaxial plane, position A in solid lines and position B in dotted lines. In position B, the x-ray source 102 and detector 104 are rotated 180 degrees about the center of rotation 140 from position A.
  • the detector center 119 is offset from the center of rotation 114 in the transaxial plane by a distance D in both position A and position B.
  • the transverse FOV 218 of the offset geometry 200 is larger than the transverse FOV 118 of the centered geometry 100 .
  • the detector center 119 may be offset from the center of rotation 114 in the transaxial plane by various distances in different embodiments of the present invention by varying the distance D.
  • the detector center 114 may be offset from the center of rotation 119 by a distance D between 0 and 35 centimeters or greater.
  • the distance D may approximate, or even exceed, the transverse half-width of the detector, so that there is a “hole” 222 in the center of the transverse FOV 218 .
  • the distance D may be varied in multiple ways to customize the size of the transverse FOV 218 .
  • the detector 104 may be shifted to vary the size of the transverse FOV 118 by any suitable means.
  • the detector 104 may be moved in various directions relative to the rotating gantry and the center of rotation 114 either manually by a human user or by a mechanical drive. It can be shifted linearly, as is useful with a flat panel detector, or rotationally, as is useful for a curved detector.
  • the exemplary offset geometry 200 described includes a centered source and an offset detector, it should be understood that additional CT imaging device geometries, which include an offset source or an offset source and an offset detector are contemplated.
  • FIG. 2A depicts an overlay of the exemplary centered geometry 100 and the exemplary offset geometry 200 .
  • the x-ray source 102 and detector 104 of the exemplary centered geometry 100 and exemplary offset geometry 200 are overlaid each other in two opposing positions in the transaxial plane, position A in solid lines and position B in dotted lines.
  • the area of the detector 104 of the exemplary centered geometry 100 in position A that overlaps with the detector 104 of the exemplary offset geometry 200 in position A is indicated by the cross-hatched section 220 in FIG. 2A .
  • projection data obtained from the exemplary centered geometry 100 and exemplary offset geometry 200 can be combined together, as if they were measured by a single larger virtual detector V. This may be accomplished, for example, with faded weighting and/or averaging the projection data obtained in the overlapping region 220 .
  • projection data may not be obtained from a centered geometry and an offset geometry, but, rather, projection data may be obtained from two different offset geometries. For example, projection data could be obtained from a scan taken with the detector center 114 offset from the center of rotation 119 by a first distance D and a second set of projection data could be obtained from another scan taken with the detector center 114 offset from the center of rotation 199 by a second distance D.
  • FIG. 3 depicts a CT imaging system 300 suitable for use with the exemplary centered geometry 100 and offset geometry 200 described above.
  • the CT imaging system 300 includes a CT data acquisition system 302 , a reconstructor 304 , an image processor 306 , a user interface 308 , and a user input 310 .
  • the CT data acquisition system 302 includes the source 102 and detector 104 , which are mounted to a rotating gantry 312 for rotation about the examination region. Circular or other angular sampling ranges as well as axial, helical, circle and line, saddle, or other desired scanning trajectories are contemplated.
  • the embodiment of the CT imaging device system 300 illustrated in FIG. 3 includes a drive 318 , such as a microstep motor, that provides the requisite force required to move the source 102 and/or detector 104 .
  • the reconstructor 304 reconstructs the data generated by the data acquisition system 302 using reconstruction techniques to generate volumetric data indicative of the imaged subject.
  • Reconstruction techniques include analytical techniques such as filtered backprojection, as well as iterative techniques.
  • the image processor 306 processes the volumetric data as required, for example for display in a desired fashion on the user interface 308 , which may include one or more output devices such as a monitor and printer and one or more input devices such as a keyboard and mouse.
  • the user interface 308 which is advantageously implemented using software instructions executed by a general purpose or other computer so as to provide a graphical user interface (“GUI”), allows the user to control or otherwise interact with the imaging system 300 , for example by selecting a desired FOV configuration or dimension, initiating and/or terminating scans, selecting desired scan or reconstruction protocols, manipulating the volumetric data, and the like.
  • GUI graphical user interface
  • a user input 310 operatively connected to the user interface 308 controls the operation of the CT data acquisition system 302 , for example to carry out a desired scanning protocol, optionally position the detector 104 and/or the source 102 so as to provide the desired FOV, and the like.
  • FIG. 4 An exemplary imaging process 400 according to one aspect of the present invention is illustrated in FIG. 4 .
  • the CT imaging system 300 is utilized to take at least one scan of the imaged subject with the source 102 and detector 104 in the centered geometry 100 to acquire projection data at a sufficient plurality of angular positions about the examination region 106 .
  • at least one scan is taken by the CT imaging system 300 with the source 102 and detector 104 in an offset geometry 200 .
  • the order of steps 402 and 404 may be reversed, as the first scan(s) may be taken with the CT imaging system 300 in the offset geometry 200 followed by scan(s) with the CT imaging system 300 in the centered geometry 100 .
  • the detector 104 and/or the source 102 of the offset geometry 200 may be offset by a variety of distances D from the center of rotation 114 in the transaxial plane.
  • one or more scanning procedures may be conducted with the detector 104 and/or the source 102 offset from the center of rotation 114 in the transaxial plane by a different distance D in each scan.
  • centered geometry projection data 406 is obtained from the centered geometry scan(s) of step 402 and offset geometry projection data 408 is obtained from the offset geometry scan(s) of step 404 .
  • the reconstructor 304 reconstructs the centered geometry projection data 406 and offset geometry projection data 408 at step 410 using known reconstruction techniques currently used in connection with offset geometry CT imaging devices to generate volumetric data indicative of the imaged subject 108 , i.e., reconstructed image data 412 .
  • the centered geometry projection data 406 and the offset geometry projection data 408 are pair-wised stitched together using the overlapping region between the projection data 406 and 408 resulting from the overlapping region 220 of the detector 104 for the registration of the projection data 406 and 408 with each other. Faded weighting and/or averaging may be optionally applied in the overlap regions of the centered geometry projection data 406 and the offset geometry projection data 408 during the reconstruction process.
  • the combined reconstruction of the projection data 406 and 408 emulates a single scan with the large virtual detector V illustrated in FIG. 2A .
  • the image acquisition method disclosed herein involves the usage of at least two scanning operations provides certain freedom with the distribution of radiation dosage during the scanning procedures.
  • Different levels of radiation dosage may be associated with each of the scan(s) of step 404 and 402 as desired by the operator of the CT imaging device 300 .
  • the offset geometry scan(s) of step 404 may be adapted to deliver less than half of the radiation dosage that is used in connection with the centered geometry scan(s) of step 402 .
  • dosage techniques can result in a better contrast-to-noise ratio being obtained for the centered geometry scan(s) of step 402 .
  • the border areas of the imaged subject scanned by the offset geometry scan(s) of step 404 which are less relevant for medical diagnosis but useful for attenuation correction, will be exposed to relatively less radiation.
  • the radiation dosage delivered to a patient during the scanning procedures of steps 402 and 404 can be tailored to be generally equivalent or less than the radiation dosage delivered to a patient during a single scan with a wide detector, such as those used in helical CT imaging.
  • Another aspect of the present invention is directed generally to a method and apparatus for the detection, estimation and/or compensation of motion artifacts encountered when reconstructing tomographic images.
  • a method and apparatus are provided for generating a motion map.
  • the motion map is utilized to indicate which image regions may be corrupted by motion artifacts and/or for motion estimation and motion compensation to prevent or diminish motion artifacts in the reconstructed tomographic image.
  • FIG. 5 An exemplary method 500 of detecting motion in reconstructed tomographic images according to one aspect of the present invention is illustrated in FIG. 5 .
  • the CT imaging system 300 is used to obtain a set of acquired projection data 504 of the imaged subject 108 .
  • tomographic reconstruction is applied to this acquired projection data 504 using known reconstruction techniques, such as filtered backprojection (FBP), to generate a reconstructed image (i.e., the “reference” image) 508 .
  • the reference image 508 may have artifacts as a result of object movement during the scanning process.
  • known forward projection techniques are applied to the previously reconstructed reference image 508 to derive reference projection data 512 .
  • reference projection data by the forward projection of a reconstructed image is a conventional aspect of iterative image reconstruction, it should be understood by those skilled in the art that the accuracy of image space interpolations and the possible truncation of projections are two important potential issues that may need to be addressed during this process. Furthermore, if the reference image 508 is reconstructed using the classical Feldkamp-Davis-Kress (FDK) algorithm, cone beam artifacts may corrupt the reference projections and hence should be accounted for.
  • FDK Feldkamp-Davis-Kress
  • the line integral differences 516 between the acquired projection data 504 and the reference projection data 512 are computed. Any such differences likely result from artifacts caused by movement of the object during the imaging scan 502 .
  • the line integral differences 516 between the acquired projection data 504 and the reference projection data 512 are computed independently for each pair of corresponding projections from the acquired projection data 504 and reference projection data 512 .
  • a data correction step could be optionally employed at this stage using, for example, the Helgason-Ludwig conditions or other similar data correction measures to correct any data inconsistencies.
  • the line integral differences 516 represent an isolation of motion that occurred during the scanning procedure 502 in projection space.
  • FIG. 6A An optional exemplary method 600 for refining the motion map 520 in accordance with an embodiment of the present invention is illustrated in FIG. 6A .
  • the line integral differences 516 may be processed or refined, such as for example by windowing, normalization, or filtering, to produce pre-processed line integral differences 604 .
  • a windowing refinement is a non-linear mapping of input values to modified output values, where input values below a given minimum value and above a given maximum value are ignored or set to zero.
  • thresholding may be applied, where input values below a given threshold are set to zero and values above the threshold are set to one.
  • Another sort of refinement is normalization, wherein the line integral differences are transformed to values between 0 and 1 to standardize and simplify subsequent mathematical calculations.
  • Yet another sort of refinement is to apply a volumetric median filter, a Gaussian blur, or some other filtering process.
  • the size of the neighborhood for the volumetric median filter and the size of the convolution kernel for the Gaussian blur are set to 3 ⁇ 3 ⁇ 3.
  • the pre-processing refinement 602 may also involve other kinds of image processing in additional embodiments.
  • the pre-processed line integral differences 604 are reconstructed using known reconstruction techniques, such as filtered backprojection (FBP), at step 606 .
  • the resulting image that is generated is a refined motion map 608 , that has been windowed, normalized, filtered, or otherwise refined.
  • the refined motion map 608 could be adapted to be either a binary motion map that simply indicates whether or not motion exists in a given image voxel or the refined motion map 608 could indicate the amplitude of the motion that exists in any given image voxel.
  • FIG. 6B Another optional exemplary method 610 for refining the motion map 520 in accordance with an embodiment of the present invention is illustrated in FIG. 6B .
  • the line integral differences 516 are reconstructed using known reconstruction techniques, such as filtered backprojection (FBP).
  • FBP filtered backprojection
  • the resulting image that is generated is an initial motion map 614 .
  • the initial motion map 614 is then processed or refined at step 616 , such as for example by windowing, normalization, filtering, to produce a post-processed refined motion map 618 .
  • the initial motion map 614 is thresholded at 150 Hounsfield units (HU).
  • Such processing or refining of the motion map 614 serves to remove “reconstruction noise” or other inconsistencies in the data and to avoid streaking
  • a motion map such as the motion map 520 , 608 or 618 has multiple uses.
  • the motion map can be used as a reference by a radiologist or other individual performing the imaging process to indicate which voxels of a particular reconstructed image could potentially contain reconstruction artifacts due to motion, e.g., regions of an image with potential motion artifacts that cause them to be unsuitable for diagnosis or localization.
  • the motion map serves as a reliability indicator to be used in conjunction with a reconstructed image, as it supplies information about the location of in-scan motion present in the reconstructed image.
  • the motion map can be combined with a motion estimation and compensation scheme to apply local motion correction during image reconstruction.
  • Conventional global motion compensation techniques are applied universally to the entire image during the reconstruction process. This can result in artifacts being introduced into regions of the reconstructed image which were not affected by any motion. As a result, in practice, these global motion compensation methods can corrupt static regions of reconstructed images with artifacts resulting from incorrect motion compensation.
  • the use of the motion map in conjunction with local motion correction prevents the application of motion compensation in static regions where no motion occurred during the scanning procedure. This can prevent artifacts in such static regions.
  • the motion map could be used as a “blending map” with motion correction techniques being applied only in those areas which are indicated to have experienced motion based upon the motion map.
  • the motion map could also be used as a “weighting map.” Under this approach, the motion map would be used to determine a “weighted” amount of motion correction that would be applied to any given image voxel, which would be an adjusted value between zero motion correction being applied and, at most, the amount of motion correction that would be applied under current conventional global motion correction techniques.
  • FIG. 8 an exemplary motion-corrupted image generated by a software program is illustrated in FIG. 8 .
  • FIG. 9 is a reconstruction of the image in FIG. 8 that has undergone global motion correction.
  • FIG. 10 is a reconstruction of the image in FIG. 8 that has undergone local motion correction using a motion map.
  • Logic includes but is not limited to hardware, firmware, software and/or combinations of each to perform a function(s) or an action(s), and/or to cause a function or action from another component.
  • logic may include a software controlled microprocessor, discrete logic such as an application specific integrated circuit (ASIC), or other programmed logic device.
  • ASIC application specific integrated circuit
  • Software includes but is not limited to one or more computer readable and/or executable instructions that cause a computer or other electronic device to perform functions, actions, and/or behave in a desired manner.
  • the instructions may be embodied in various forms such as routines, algorithms, modules or programs including separate applications or code from dynamically linked libraries.
  • Software may also be implemented in various forms such as a stand-alone program, a function call, a servlet, an applet, instructions stored in a memory, part of an operating system or other type of executable instructions. It will be appreciated by one of ordinary skill in the art that the form of software is dependent on, for example, requirements of a desired application, the environment it runs on, and/or the desires of a designer/programmer or the like.
  • the systems and methods described herein can be implemented on a variety of platforms including, for example, networked control systems and stand-alone control systems. Additionally, the logic, databases or tables shown and described herein preferably reside in or on a computer readable medium, such as a component of the imaging system 300 . Examples of different computer readable media include Flash Memory, Read-Only Memory (ROM), Random-Access Memory (RAM), programmable read-only memory (PROM), electrically programmable read-only memory (EPROM), electrically erasable programmable read-only memory (EEPROM), magnetic disk or tape, optically readable mediums including CD-ROM and DVD-ROM, and others. Still further, the processes and logic described herein can be merged into one large process flow or divided into many sub-process flows. The order in which the process flows herein have been described is not critical and can be rearranged while still accomplishing the same results. Indeed, the process flows described herein may be rearranged, consolidated, and/or re-organized in their implementation as warranted or desired.

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US9710936B2 (en) 2017-07-18
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EP2586374A2 (fr) 2013-05-01
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CN102325499A (zh) 2012-01-18
US20160005194A1 (en) 2016-01-07
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