US20110046116A1 - Sedative for use during eye surgery - Google Patents
Sedative for use during eye surgery Download PDFInfo
- Publication number
- US20110046116A1 US20110046116A1 US12/858,475 US85847510A US2011046116A1 US 20110046116 A1 US20110046116 A1 US 20110046116A1 US 85847510 A US85847510 A US 85847510A US 2011046116 A1 US2011046116 A1 US 2011046116A1
- Authority
- US
- United States
- Prior art keywords
- sedative
- eye surgery
- patient
- nicotine
- mixture
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 230000001624 sedative effect Effects 0.000 title claims abstract description 24
- 239000000932 sedative agent Substances 0.000 title claims abstract description 22
- 238000001356 surgical procedure Methods 0.000 title claims abstract description 18
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 claims abstract description 13
- 229960002715 nicotine Drugs 0.000 claims abstract description 13
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 claims abstract description 13
- 239000000203 mixture Substances 0.000 claims abstract description 12
- 239000003814 drug Substances 0.000 claims abstract description 9
- 229940079593 drug Drugs 0.000 claims abstract description 8
- DDLIGBOFAVUZHB-UHFFFAOYSA-N midazolam Chemical compound C12=CC(Cl)=CC=C2N2C(C)=NC=C2CN=C1C1=CC=CC=C1F DDLIGBOFAVUZHB-UHFFFAOYSA-N 0.000 claims abstract description 8
- 229960003793 midazolam Drugs 0.000 claims abstract description 8
- 238000000034 method Methods 0.000 claims description 8
- 208000002177 Cataract Diseases 0.000 description 3
- 206010028347 Muscle twitching Diseases 0.000 description 3
- 238000002513 implantation Methods 0.000 description 2
- 206010039897 Sedation Diseases 0.000 description 1
- 230000036461 convulsion Effects 0.000 description 1
- 230000004438 eyesight Effects 0.000 description 1
- 230000008014 freezing Effects 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 238000010253 intravenous injection Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000036280 sedation Effects 0.000 description 1
- 229940125723 sedative agent Drugs 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
- A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/465—Nicotine; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
Definitions
- the present invention relates generally to pharmaceuticals and, more particularly, to an intravenous drug for use prior to eye surgery.
- the patient is mildly sedated with a sedative, such as midazolam, which is sold under the trademark Versed®.
- a sedative such as midazolam
- Versed® a sedative for many people, sedation by midazolam together with freezing the eye is sufficient to render the eye sufficiently stable permit the surgical procedure.
- the present invention provides a drug which overcomes all of the above-mentioned disadvantages of the previously known drugs.
- a sedative such as midazolam
- nicotine is mixed with nicotine to form an injectable dose.
- the ratio of sedative to nicotine ranges from 2:1 to 1:2.
- the mixture of the sedative and nicotine Prior to the eye surgery, the mixture of the sedative and nicotine is injected into the patient in the standard fashion. It has been found, however, that the addition of the nicotine to the sedative reduces twitching and fidgeting of patients who are smokers and particularly patients who are heavy smokers.
- FIGURE is a flowchart illustrating the method of the present invention.
- a sedative and nicotine are intermixed at step 10 . Both the sedative and the nicotine are in liquid form.
- the sedative comprises midazolam although other sedatives may alternatively be used without deviation from the scope or spirit of the invention.
- the ratio of sedative to nicotine in the mixture ranges between 2:1 to 1:2 by volume.
- the mixture is injected into the patient at step 20 .
- the addition of the nicotine to the sedative reduces twitching and fidgeting by the patient, particularly when the patient is a heavy smoker. This, in tam, allows the doctor to perform the eye surgery without the need to perform higher risk medical procedures on the patient prior to the eye surgery.
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Anesthesiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
A drug for sedating a patient, and especially a smoker, during eye surgery. The drug includes a sedative such as midazolam in a mix with nicotine. The mixture is injected into the patient prior to the eye surgery.
Description
- This application claims priority of U.S. Provisional Patent Application Ser. No. 61/235,470 filed Aug. 20, 2009, which is incorporated herein by reference.
- I. Field of the Invention
- The present invention relates generally to pharmaceuticals and, more particularly, to an intravenous drug for use prior to eye surgery.
- II. Description of Related Art
- Eye surgery for the removal of cataracts and the subsequent implantation of an artificial lens, after the cataract has been removed has become an increasingly common surgical procedure. During such procedure, it is necessary that the patient and his or her eye remain perfectly still to allow the proper insertion not only of the surgical tools, but also the artificial lens, during the eye surgery.
- Typically, the patient is mildly sedated with a sedative, such as midazolam, which is sold under the trademark Versed®. For many people, sedation by midazolam together with freezing the eye is sufficient to render the eye sufficiently stable permit the surgical procedure.
- Smokers, and particularly heavy smokers, however, have presented a new challenge to eye surgery involving the removal of cataracts and the subsequent implantation of the artificial lens. It has been discovered that when such patients are sedated by a sedative, such as midazolam, alone, the patient nevertheless fidgets and twitches during the eye surgery. When this occurs, it is necessary to use other medical procedures to completely sedate the patient and completely prevent the movement of the patient's eye during the surgical procedure. These other medical procedures, however, disadvantageously pose greater surgical risk, even the loss of eyesight, for the patient as opposed to a simple intravenous injection of a sedative.
- The present invention provides a drug which overcomes all of the above-mentioned disadvantages of the previously known drugs.
- In brief, in the present invention a sedative, such as midazolam, is mixed with nicotine to form an injectable dose. The ratio of sedative to nicotine ranges from 2:1 to 1:2.
- Prior to the eye surgery, the mixture of the sedative and nicotine is injected into the patient in the standard fashion. It has been found, however, that the addition of the nicotine to the sedative reduces twitching and fidgeting of patients who are smokers and particularly patients who are heavy smokers.
- A better understanding of the present invention will be had upon reference to the following detailed description when read in conjunction with the accompanying drawing in which the single FIGURE is a flowchart illustrating the method of the present invention.
- With reference to the drawing, prior to eye surgery of a patient, and especially a patient who is a heavy smoker, a sedative and nicotine are intermixed at
step 10. Both the sedative and the nicotine are in liquid form. - Preferably, the sedative comprises midazolam although other sedatives may alternatively be used without deviation from the scope or spirit of the invention. Furthermore, the ratio of sedative to nicotine in the mixture ranges between 2:1 to 1:2 by volume.
- After the mixture is formed in
step 10, the mixture is injected into the patient at step 20. In practice, it has been discovered that the addition of the nicotine to the sedative reduces twitching and fidgeting by the patient, particularly when the patient is a heavy smoker. This, in tam, allows the doctor to perform the eye surgery without the need to perform higher risk medical procedures on the patient prior to the eye surgery. - Having described my invention, however, many modifications thereto will become apparent to those skilled in the art to which it pertains without deviation from the spirit of the invention as defined by the scope of the appended claims.
Claims (6)
1. A drug for sedating a patient during eye surgery comprising:
a sedative, and
nicotine intermixed with said sedative to form a mixture, said mixture being injected into the patient prior to the eye surgery.
2. The drug mixture as defined in claim 1 wherein said sedative comprises midazolam.
3. The drug mixture as defined in claim 1 wherein the ratio of sedative to nicotine by volume is in the range of 2:1 to 1:2.
4. A method of sedating a patient prior to eye surgery comprising the steps of:
mixing a sedative and nicotine together to form a mixture, and
injecting said mixture into the patient.
5. The method of claim 4 wherein said sedative comprises midazolam.
6. The method of claim 4 wherein the ratio of sedative to nicotine by volume is in the range of 2:1 to 1:2.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12/858,475 US20110046116A1 (en) | 2009-08-20 | 2010-08-18 | Sedative for use during eye surgery |
| US13/971,970 US8722666B2 (en) | 2009-08-20 | 2013-08-21 | Sedative for use during eye surgery |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23547009P | 2009-08-20 | 2009-08-20 | |
| US12/858,475 US20110046116A1 (en) | 2009-08-20 | 2010-08-18 | Sedative for use during eye surgery |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| US13/971,970 Division US8722666B2 (en) | 2009-08-20 | 2013-08-21 | Sedative for use during eye surgery |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| US20110046116A1 true US20110046116A1 (en) | 2011-02-24 |
Family
ID=43605838
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| US12/858,475 Abandoned US20110046116A1 (en) | 2009-08-20 | 2010-08-18 | Sedative for use during eye surgery |
| US13/971,970 Active US8722666B2 (en) | 2009-08-20 | 2013-08-21 | Sedative for use during eye surgery |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| US13/971,970 Active US8722666B2 (en) | 2009-08-20 | 2013-08-21 | Sedative for use during eye surgery |
Country Status (1)
| Country | Link |
|---|---|
| US (2) | US20110046116A1 (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10821087B2 (en) | 2015-07-24 | 2020-11-03 | Neon Laboratories Limited | Stabilized injectable emulsion of Propofol and Ketamine |
| US10925864B2 (en) | 2015-07-18 | 2021-02-23 | Neon Laboratories Limited | Stable liquid injectable solution of midazolam and pentazocine |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040102440A1 (en) * | 2002-07-01 | 2004-05-27 | Wong Erik Ho Fong | Method of promoting smoking cessation |
-
2010
- 2010-08-18 US US12/858,475 patent/US20110046116A1/en not_active Abandoned
-
2013
- 2013-08-21 US US13/971,970 patent/US8722666B2/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040102440A1 (en) * | 2002-07-01 | 2004-05-27 | Wong Erik Ho Fong | Method of promoting smoking cessation |
Non-Patent Citations (1)
| Title |
|---|
| Imidazolam Injection, Drug Indications-Dosage. * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10925864B2 (en) | 2015-07-18 | 2021-02-23 | Neon Laboratories Limited | Stable liquid injectable solution of midazolam and pentazocine |
| US10821087B2 (en) | 2015-07-24 | 2020-11-03 | Neon Laboratories Limited | Stabilized injectable emulsion of Propofol and Ketamine |
Also Published As
| Publication number | Publication date |
|---|---|
| US8722666B2 (en) | 2014-05-13 |
| US20130338149A1 (en) | 2013-12-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| STCB | Information on status: application discontinuation |
Free format text: ABANDONED -- FAILURE TO RESPOND TO AN OFFICE ACTION |