US20100241185A1 - Steerable epicardial pacing catheter system placed via the subxiphoid process - Google Patents

Steerable epicardial pacing catheter system placed via the subxiphoid process Download PDF

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Publication number: US20100241185A1
Authority: US; United States
Prior art keywords: catheter; epicardial pacing; epicardial; pacing catheter; communication
Prior art date: 2007-11-09
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Abandoned

Application number

US12/741,710

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English (en)

Inventor

Srijoy Mahapatra

George T. Gillies

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

UVA Licensing and Ventures Group

Original Assignee

University of Virginia Patent Foundation

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-11-09

Filing date

2008-11-07

Publication date

2010-09-23

2008-11-07 Application filed by University of Virginia Patent Foundation filed Critical University of Virginia Patent Foundation

2008-11-07 Priority to US12/741,710 priority Critical patent/US20100241185A1/en

2010-08-13 Assigned to UNIVERSITY OF VIRGINIA reassignment UNIVERSITY OF VIRGINIA ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: MAHAPATRA, SRIJOY, GILLIES, GEORGE T.

2010-08-13 Assigned to UNIVERSITY OF VIRGINIA PATENT FOUNDATION reassignment UNIVERSITY OF VIRGINIA PATENT FOUNDATION ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: UNIVERSITY OF VIRGINIA

2010-09-23 Publication of US20100241185A1 publication Critical patent/US20100241185A1/en

Status Abandoned legal-status Critical Current

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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
- A61N1/0587—Epicardial electrode systems; Endocardial electrodes piercing the pericardium

Definitions

the present technology relates generally to the field of medical devices to be used for cardiological procedures. More specifically, the technology is in the subfield of catheterization devices to be used for epicardial pacing.
LV leads left ventricular leads
the electrical lead can not be placed directly into the LV due to the unacceptably high risk of stroke.
the lead must, therefore, be placed on the surface of the LV.
a lead is threaded through the right atrium (RA) using a venous system, and passed through the coronary sinus (CS) to any of a number of small veins in communication with the surface of the LV.
RA right atrium
CS coronary sinus
An aspect of an embodiment (or partial embodiment thereof) of the present invention includes an apparatus and means for treating congestive heart failure and arrhythmias (both bradycardias and tachycardias) of the heart.
the invention provides for a novel means and method of placing an epicardial lead within a patient for the purpose of permanent multi-site, cardiac pacing and defibrillation, including left ventricular pacing.
An aspect of an embodiment (or partial embodiment thereof) of the present invention includes a lead that paces LV, RV, LA and RA at the same time or in sequence. It could even pace two separate points on the same chamber (the LV or the RV) at the same time or at some offset. This has an important advantage, for example, if a region of tissue ever dies in heart attack, the present invention method can still pace from elsewhere.
An aspect of an embodiment (or partial embodiment thereof) of the present invention may include placing a bipolar pacing lead through a subxiphoid incision and then channeling it back to a pacemaker.
the procedure may evolve through three distinct stages. In the earliest stage, one would place the lead on the left ventricle and tunnel it underneath the pectoral muscle back to the chest wall where the pacemaker would normally be placed. In the second, one would place the lead back to the subxiphoid process, attach it to a battery that is positioned just on the outside of the xiphoid process and have it wirelessly communicate with the main pacemaker. Lastly one would place a button-like object right on the top of the left ventricle and then communicate wirelessly back to the main pacemaker. Still yet, another embodiment of the means and method of the invention may include having the battery, anode and cathode means all compounded on the end of the lead so that there would not be any need to have another excision to bring any of the components back out of the heart.
An aspect of an embodiment or partial embodiment of the present invention comprises an epicardial pacing system.
the system may comprise: an epicardial catheter configured to be disposed in the middle mediastinum of the thorax of a subject for use in electrical pacing of the heart at one or more locations on the epicardial surface.
the epicardial pacing catheter comprising: a proximal portion, distal portion, and a longitudinal structure there between; and at least one electrode in communication with the distal portion, wherein the at least one electrode is insulated on at least one side to allow pacing of the heart without damage to adjacent anatomical structures.
An aspect of an embodiment or partial embodiment of the present invention comprises a method for use with an epicardial pacing catheter.
the method may comprise: disposing the epicardial pacing catheter in the middle mediastinum of the thorax of a subject; and pacing the heart at one or more locations with electrical energy from an at least one electrode; and at least partially insulating the electrical energy to allow pacing of the heart without damage to adjacent anatomical structures.
the epicardial pacing system and related method includes an epicardial catheter configured to be disposed in the middle mediastinum of the thorax of a subject for use in electrical pacing (and/or other diagnostic or therapeutic procedure) of the heart at one or more locations on the epicardial surface.
the epicardial pacing catheter may include at least one electrode whereby the electrode is insulated on at least one side to allow pacing of the heart without damage to adjacent anatomical structures.
FIG. 1 schematically illustrates the overall configuration of the epicardial pacing catheter system.
FIG. 2 schematically illustrates the pericardium and heart alone ( FIG. 2(A) ) and an example embodiment in position relative to the heart ( FIG. 2(B) ).
FIG. 3 schematically illustrates an example embodiment passively disposed within the pericardial sack of the heart.
FIGS. 4 (A)-(C) schematically illustrate a number of exemplary embodiments of the steering means employed to position the distal portion of an exemplary embodiment of the epicardial pacing catheter in un-tensioned, partial steering, and full steering modes, respectively.
FIGS. 5(A)-5(D) schematically illustrate a number of exemplary embodiments of the epicardial pacing catheter 10 near the distal portion.
FIGS. 6(A)-6(F) schematically illustrate cross sectional views of an exemplary embodiment of the technology from the most distal end to a more proximal point.
FIGS. 7(A) and (B) schematically illustrate cross sectional views of an exemplary embodiment of the most proximal portion of an exemplary embodiment of the epicardial pacing catheter and the most distal portion of an exemplary embodiment of the control means, respectively.
FIGS. 8 (A)-(C) schematically illustrate cross-sectional views of an example embodiment further comprising a stabilization means for stabilizing the example embodiment.
the stabilization means illustrated in an un-deployed position, partially deployed position, and deployed position, respectively.
FIG. 9 schematically illustrates an example embodiment of the epicardial pacing catheter further comprising deployable electrodes fixed or adjacent to the heart.
FIG. 10(A) schematically illustrates a top view of an exemplary embodiment of the epicardial pacing catheter.
FIG. 10(B) schematically illustrates a bottom view of an exemplary embodiment of the epicardial pacing catheter.
FIG. 10(C) schematically illustrates an axial view of an exemplary embodiment of the epicardial pacing catheter looking at the distal tip of the insulating hood.
FIG. 10(D) schematically illustrates a perspective view of an exemplary embodiment of the epicardial pacing catheter.
FIG. 11(A)-11(E) schematically illustrate cross sectional views of an exemplary embodiment of the epicardial pacing catheter from a point located proximal to the at least one electrode and distal to the distal point of curvature to a point located at the most proximal point of the epicardial pacing catheter.
FIG. 11(F) schematically illustrates a cross sectional view of an exemplary embodiment of the control handle at the most distal point.
FIG. 12(A) schematically illustrates a cross section of an exemplary embodiment of the epicardial pacing catheter comprising a deployable anode and cathode in an un-deployed state.
FIG. 12(B) schematically illustrates a cross section of an exemplary embodiment of the epicardial pacing catheter comprising a deployable anode and cathode in a fully-deployed state.
FIG. 13(A) schematically illustrates a cross section of an exemplary embodiment of the epicardial pacing catheter comprising a deployable screw or the like in an un-deployed state.
FIG. 13(B) schematically illustrates a cross section of an exemplary embodiment of the epicardial pacing catheter comprising a deployable screw or the like in a fully-deployed state.
FIG. 14(A) schematically illustrates a cross section of an exemplary embodiment of the epicardial pacing catheter comprising a deployable anode and cathode in an un-deployed state.
FIG. 14(B) schematically illustrates a cross section of an exemplary embodiment of the epicardial pacing catheter comprising a deployable anode and cathode in a fully-deployed state.
FIG. 15(A) schematically illustrates an example embodiment of an external control handle.
FIG. 15(B) schematically illustrates an example embodiment of the proximal steering control means or a least part of the steering control means integral to the control handle.
FIG. 15(C) schematically illustrates an example embodiment wherein the proximal steering control means or a least part of the steering control means integral to the control handle has been activated.
FIG. 1 schematically illustrates an overview of an exemplary embodiment of the epicardial pacing system 5 comprising an epicardial pacing catheter 10 in communication with at least one electrode 43 , a control means or control handle 150 , an interface member 162 , a processor 164 or computer, power supply 166 or battery, or voice control instrumentation/system 168 .
the control means 150 may be in communication with the proximal portion of the catheter 10 , wherein the control means 150 is controllably connected to at least one electrode 43 .
the control means may be a control handle or controller as desired or required.
the control handle (or control means) may be removable.
the epicardial pacing catheter 10 may further comprises a processor 164 or computer.
the processor 164 may be in communication with said epicardial pacing catheter 10 and system.
the processor 164 may be located at or near the patient's shoulder, for example.
the epicardial pacing catheter 10 further comprises an interface member 162 in communication with said epicardial pacing catheter 10 .
the interface member 162 may be in remote and/or local communication with the processor 164 , pacing system 5 , catheter 10 , controller 150 , power supply 166 , and/or voice control instrumentation to provide information to and/or from a patient, physician, technician, or a clinician. Further, any of the components and systems illustrated in FIG. 1 may be in communication with each other, as well as other systems, computers, devices, printers, displays, PDAs, networks, memory storage, and voice control instrumentations as desired or required.
the epicardial pacing system 5 may comprise a power supply 166 .
the power supply 166 may comprise a small battery located at the subxiphoid area, preferably of a silicone silver-gallium kind designed specifically for use in implantable cardiac defibrillators (ICDs).
ICDs implantable cardiac defibrillators
the power characteristics of the particular battery may be such that it can maintain the same voltage for a long period of time before falling off suddenly.
the epicardial pacing system 5 and epicardial pacing catheter 10 may further comprise a wireless communication system, wherein the processor 164 , power supply 166 , voice control instrumentation 168 , interface member 162 or desired components of the system 5 may be wirelessly connected to one another.
the battery and processor 164 are both located in the subxiphoid area.
any of the components or modules referred to with regards to any of the present technology embodiments discussed herein, may be integrally or separately formed with one another. Further, redundant functions or structures of the components or modules may be implemented. Moreover, the various components may be communicated locally and/or remotely with any user/clinician/patient or machine/system/computer/processor. Moreover, the various components may be in communication via wireless and/or hardwire or other desirable and available communication means, systems and hardwares.
the epicardial pacing catheter 10 in accordance with the present technology may comprise a proximal portion, a distal portion, and a longitudinal structure there between. It should be appreciated that the distal portion may be considered at the distal end tip of the epicardial pacing catheter 10 ; or a portion or segment at or in the vicinity of the distal end tip of the epicardial pacing catheter 10 or a portion or segment leading up to (or partially up to but not all the way up to) the distal end of the catheter 10 as desired or required. The length and location of the distal portion may vary as desired or required in order to practice the technology according to medical procedures and anatomical considerations.
proximal portion may be considered the tip of the beginning of the catheter 10 ; or a portion or segment at or in the vicinity of the proximal end of the catheter 10 or a portion or segment leading up to (or partially up to but not all the way up to) the proximal end of the catheter 10 as desired or required.
the length and location of the proximal portion may vary as desired or required in order to practice the technology according to medical procedures and anatomical considerations.
the proximal portion, distal portion and longitudinal structure there between may be integrally formed from a biocompatible material having requisite strength and flexibility for deployment within a patient.
the proximal portion, distal portion, and longitudinal structure there between may have a lubricious outer surface comprising a material having a low coefficient of friction, such as, but not limited to, silicone, polyurethane, or Teflon, or combination thereof.
the proximal portion, distal portion, and longitudinal structure there between may further have an outer surface comprising a drug eluting surface and/or a surface impregnated with sirilimus to prevent the production of fibrosis within a patient.
the longitudinal structure may be between about 15 cm and about 100 cm in length, and between about 2 mm and about 6 mm in diameter. It should be appreciated that the length of the longitudinal structure may be longer or shorter as may be desired or required according to medical procedures, device/system operations and anatomical considerations.
the cross section of the longitudinal structure comprises an oval, circle, ellipse, polygon, or semi-circular shape.
the longitudinal structure may be any one of: lumen, conduit, channel, passage, pip, tunnel or bounded tubular surface.
the epicardial pacing catheter 10 further comprises at least one electrode 43 in communication with the distal portion, wherein the at least one electrode 43 is insulated on at least one side to allow pacing of the heart without damage to adjacent structures.
the at least one electrode 43 may be constructed of platinum, gold, silver, iridium, or any alloy thereof, or other conducting materials known in the art.
the at least one electrode 43 may comprise a roughened, profiled, or otherwise prepared surface to increase the total surface area for energy transmission.
the at least one electrode 43 may be semi-cylindrical or arc-like in shape, and may be contoured to be compatible with proximate anatomical structures.
the at least one electrode 43 may be between about 0.3 mm and about 4 mm in length, and may be spaced between about 1 mm and about 25 mm from each other.
the at least one electrode 43 may be a pair of electrodes, commonly referred to as an anode and cathode in the art.
the at least one electrode 43 may be deployable. It should be appreciated that the length of the electrodes may be longer or shorter as may be desired or required according to medical procedures, device/system operations and anatomical considerations.
various sheaths, catheters and guidewires, or any related components disclosed herein may have a circular or oval-shaped cross-section or various combinations thereof. Further, it should be appreciated that various sheaths, catheters and guidewires, or any related components disclosed herein may have any variety of cross sections as desired or required for the medical procedure or anatomy.
any of the components or modules referred to with regards to any of the present invention embodiments discussed herein may be a variety of materials and/or composites as necessary or required. Still further, it should be appreciated that any of the components or modules (or combination thereof) may provide shape, size and volume contoured by adjusting its geometry and flexibility/rigidity according to the target location or anatomy (or region, including structure and morphology of any location) being treated.
FIG. 2(A) schematically illustrates the pericardium and heart alone.
the pericardium 22 is shown in close proximity to the epicardium 23 .
FIG. 2(B) schematically illustrates three contiguous sections of an example embodiment implanted around the heart 21 .
the epicardial pacing catheter 10 of the epicardial pacing system 5 is positioned in the pericardial space, cavity or sack 24 , or the area between the pericardium 22 and epicardium 23 . All of the electrodes 43 are facing the heart 21 .
the epicardial pacing catheter 10 further comprises outward facing bumper tabs 31 and inward facing friction tabs 32 to stabilize the epicardial pacing catheter 10 from moving within the pericardial sack 24 , once it is implanted.
an aspect of an embodiment of the present technology may be implemented with an access needle (introducer needle), conduit or the like.
the access needle or conduit is adapted to be inserted into the epicardial region or other body part or body space so as to provide an access or guideway for the epicardial pacing catheter 10 .
An example of an access system is disclosed in PCT International Application No. Serial No. PCT/US2008/056643, filed Mar. 12, 2008, entitled, “Access Needle Pressure Sensor Device and Method of Use,” of which is hereby incorporated by reference herein in its entirety. See for example, but not limited thereto, FIGS. 2 and 5 of the '056643 PCT Application.
the access needle sensor device or the like serves as a guideway for introducing other devices into the pericardium 22 , for instance, sheath catheters that might subsequently be employed for procedures within the pericardium 22 or other applicable regions, space or anatomy.
Other devices that the access device may accommodate with the practice of this invention include, but are not limited thereto, the following: ablation catheters, guide wires, other catheters, visualization and recording devices, drugs, and drug delivery devices, lumens, steering devices or systems, drug or cell delivery catheters, fiber endoscopes, suctioning devices, irrigation devices, electrode catheters, needles, optical fiber sensors, sources of illumination, vital signs sensors, and the like. These devices may be deployed for procedures in an integral body part or space.
any data, feedback, readings, or communication from the system may be received by the user, clinician, physician, or technician or the like by visual graphics, audible signals (such as voice or tones, for example) or any combination thereof. Additionally, the data, feedback, or communication may be reduced to hard copy (e.g., paper) or computer storage medium. It should be appreciated that the pressure related readings and data may be transmitted not only locally, but remotely as well.
an aspect of the invention may be in the field of voice control over medical systems and devices of use in specialized electrophysiology procedures that employ subxiphoid access for the purpose of navigating an interventional or surgical probe onto the epicardial surface of the heart, via pericardial transit.
the invention may be in the specialized category of voice control over instruments and systems that measure the intrathoracic and intrapericardial pressures during the process of navigating said intrathoracic or surgical probe within the patient following subxiphoid insertion.
An aspect of an embodiment or partial embodiment of the subject invention is one of providing the working electrophysiologist with a means and method for controlling the operational parameters (e.g., the display functions) of diagnostic and therapeutic cardiological equipment by voice, thus eliminating either the need to temporarily take their hands off the patient or the need to have an additional EP Lab technician available to perform such tasks. (Such personnel are often needed to insure that the clinician need never touch anything outside the sterile field.).
voice control instrumentation that teach applications in medical applications but not in electrophysiological approaches to cardiological problems include U.S. Pat. Nos.
present invention system and method may further comprise imaging said the access needle and the epicardial pacing system (and components thereof) with at least one of magnetic resonance imaging, computed tomography, fluoroscopy, or other radiological modalities.
readings are provided from said sensing of pressure for navigating said needle access and the epicardial pacing system (and components thereof).
the deploying of the epicardial pacing catheter 10 into the pericardial sack 24 may be minimally invasive, non-surgical, and/or interventional.
the deploying of the epicardial pacing catheter 10 may be performed by a non-surgeon and/or cardiologist through use of an access needle and subsequent passage of a guidewire.
the access needle may first be inserted through the chest and into the pericardium 22 , with the guidewire then put in place.
the epicardial pacing catheter 10 may then be coaxially slid over the guidewire to access the pericardial sack 24 .
the insertion of a sheath into the pericardial sack 24 may be aided by the use of an access needle and subsequent passage of a guidewire.
the access needle may first be inserted into the epicardium, with the guidewire then put in place.
the sheath may then be coaxially slid over the guidewire to access the pericardial sack 24 .
the epicardial pacing catheter 10 may then be inserted through the sheath to reach the epicardium 23 .
the guideway provides coaxial alignment for the at least one of guide wire, sheath or catheter, which can be inside or outside the needle.
the at least one guide wire, sheath, or catheter can also be coaxially aligned with one another.
multiple lumens may be implement and configured between the plurality of distal apertures and plurality proximal apertures. It should be appreciated that coaxial alignment does not need to be exact, but rather one conduit, lumen, sheath, or guidewire slid outside or inside of another.
an epicardial access needle-stick may be implemented in the subxiphoid area of the chest and the epicardial pacing catheter 10 only need be advanced a short distance to get to the heart 21 . However, it may immediately be steered though an acute angle to avoid the heart itself Because of this, aspects of the present invention devices and those used in conventional techniques can be contrasted.
conventional endocardial catheters may typically be up to 100 cm in length or longer since they must go from the shoulder to the heart, while an embodiment of the present technology could be, for example, about 20 cm or less since it may only need to go from the chest to the heart. It should be appreciated that the length may be greater than about 20 cm as well. It should be appreciated that the length of the present invention catheter may be longer or shorter as may be desired or required according to medical procedures, device/system operations and anatomical considerations.
a subject may be a human or any animal. It should be appreciated that an animal may be a variety of any applicable type, including, but not limited thereto, mammal, veterinarian animal, livestock animal or pet type animal, etc. As an example, the animal may be a laboratory animal specifically selected to have certain characteristics similar to a human (e.g. rat, dog, pig, monkey), etc. It should be appreciated that the subject may be any applicable human patient.
FIG. 3 schematically illustrates an example embodiment of the epicardial pacing catheter 10 of the epicardial pacing system 5 passively disposed within the pericardial sack 24 (shown with hash marks) of the heart 21 .
the epicardial pacing catheter 10 may be used to pace the left ventricle, right ventricle, right atrium, and left atrium. It should be appreciated that the present technology may be used to pace the left ventricle, left atrium, right atrium, right ventricle and/or any combination thereof.
the epicardial pacing catheter 10 may first be inserted into the pericardium 22 at the insertion point 33 , which may be located at an anterior portion (towards the sternum) of the pericardium 22 , adjacent to the left ventricle. The catheter is then advanced posteriorly (towards the spine) within the pericardial sack 24 towards the left atrium, right atrium and transverse sinus. The catheter is further advanced around the posterior of the heart, and pushed anteriorly toward the right ventricle. Once the catheter is in contact with the left ventricle, right ventricle, right atrium and left atrium, a deployable stabilization means may be deployed. Both outward facing bumper tabs 31 and inward facing friction tabs 32 are shown, and prevent the catheter from moving or slipping.
the inward facing friction tabs 32 may interact with the outside wall of structures such as, but not limited to, the transverse sinus, superior vena cava, right inferior pulmonary vein, and the right superior pulmonary vein to prevent the catheter from dislodging.
the outward facing bumper tabs 31 may push on the pericardium to further secure the catheter 10 against the epicardium (for example, as shown in FIG. 2 ).
FIGS. 4 (A)-(C) provide schematic illustrations of some of the operational aspects of an exemplary embodiment of the steering means, system or device associated with the epicardial pacing catheter 10 of the epicardial pacing system.
the epicardial pacing catheter 10 further comprises a distal steering means (not shown) and a proximal steering means (not shown) which may have the steering characteristics taught by Mahapatra et al. in PCT International Application No. PCT/US2008/056816, filed Mar. 13, 2008, entitled, “Epicardial Ablation Catheter and Method of Use,” hereby incorporated by reference herein in its entirety.
the steering means may comprise guidewires, tensioning lines, pull strings, digitating distal tips, magnetic guidance means, wires, rods, chains, bands, chords, ropes, string tubes, filaments, threads, fibers, strands, other extended elements, or any other method known in the art.
FIGS. 7(A)-7(B) of '056816 PCT International Application there is provided some details of an exemplary mechanism of action for directional steering of the proximal segment of the device that may be implemented for the present technology.
proximal steering means as shown in FIG. 15(B)
distal steering means not shown
the proximal point of curvature 42 may be located between about 1 cm and about 25 cm from the proximal end and the distal point of curvature 41 may be located between about 1 cm and about 20 cm from the distal end. It should be appreciated that the proximal and distal points of curvature may be located at other longer or shorter points and may be implemented as may be desired or required according to medical procedures, device/system operations and anatomical considerations.
the steering means are used to direct the epicardial pacing catheter 10 through or navigate it within a patient's body. It should be noted that, while two steering means and points of curvature are shown, the epicardial pacing catheter 10 may further comprise a third and fourth steering means for steering the epicardial pacing catheter 10 around a third and fourth point of curvature. Moreover, though a bi-directional distal point of curvature 41 is shown, it should be appreciated that all points of curvature may be uni-directional, bi-direction, tri-direction, quadra-directional, or greater than quadra-directional.
FIG. 4(A) shows an embodiment of the epicardial pacing catheter 10 in the non-deflected state.
FIG. 4(B) shows the epicardial pacing catheter 10 in a partially-deflected state.
FIG. 4(C) shows the epicardial pacing catheter 10 in a fully-deflected state, as would be the case when it has been navigated into the pericardial space of a subject's heart, or other space or structure.
the at least one electrode 43 is held against a patient's heart by the stabilization means, shown as the inward facing friction tabs 32 and outward facing bumper tabs 31 .
FIGS. 5(A)-5(D) schematically illustrate a number of embodiments of the epicardial pacing catheter 10 of the epicardial pacing system near the distal portion.
FIG. 5(A) schematically illustrates an exemplary embodiment wherein the epicardial pacing catheter 10 may be used to pace the left ventricle (LV) of a patient's heart.
a number of electrodes 43 are adapted to transmit electrical energy to the left ventricle, and are shown facing the left ventricle.
the number of electrodes 43 may vary depending on the number of locations required or desired to be paced.
the electrodes 43 may be insulated on at least one side away from the heart, as to prevent electrical energy from being transmitted to proximate anatomical structures. The insulation may be about 2 mm thick, and may extend longitudinally through the epicardial pacing catheter 10 .
the thickness may be wider or narrower as desired or required according to medical procedures, device/system operations and anatomical considerations.
the insulation may comprise Teflon, silicone, polyurethane, and/or any combination thereof or any other non-conductive material known in the art.
Outward facing bumper tabs 31 are deployable, and are used to stabilize the epicardial pacing catheter 10 by pushing against the pericardium. As shown, the outward facing bumper tabs 31 are in the non-deployed state as to allow the epicardial pacing catheter 10 to move within the pericardium. Although not shown, the epicardial pacing catheter may further comprise inward facing friction tabs 32 or other stabilization means.
the epicardial pacing catheter 10 further comprises a distal tip 51 in communication with the epicardial pacing catheter 10 .
the distal tip 51 extends from the body of the catheter 10 and may further insulate the electrodes 43 from proximate anatomical structures and/or be used to push through harder anatomical structures and adhesions as desired or required.
FIG. 5(B) schematically illustrates an exemplary embodiment wherein the epicardial pacing catheter 10 may be used to pace the left ventricle (LV) and left atrium (LA) of a patient's heart. Additional electrodes 43 near the distal point of curvature 41 are shown. These electrodes 43 may be in communication with the outside wall of the left atrium in order to pace said structure. Additional outward facing bumper tabs 31 are present to press against the pericardium in more distal locations. Inward facing friction tabs 32 are now shown. The inward facing friction tabs 32 may be deployed to catch, drag, stick to, or pull on adjacent anatomical structures to keep the epicardial pacing catheter 10 from moving. FIG. 5(B) shows an example embodiment wherein both the inward facing friction tabs 32 and outward facing bumper tabs 33 are in the non-deployed state to allow movement of the catheter 10 .
FIG. 5(C) schematically illustrates an exemplary embodiment wherein the epicardial pacing catheter 10 may be used to pace the left ventricle (LV), left atrium (LA), and right atrium (RA). Additional electrodes 43 are located near the distal point of curvature 41 . These electrodes 43 may be in communication with the outside wall of the right atrium in order to pace said structure. Further, additional outward facing bumper tabs 31 are present to press against the pericardium in more distal locations.
LV left ventricle
LA left atrium
RA right atrium
FIG. 5(D) shows an example embodiment wherein the epicardial pacing catheter 10 may be used to pace multiple points on the left ventricle (LV), left atrium (LA), right atrium (RA), and right ventricle (RV). Additional electrodes 43 are shown in a more distal location in order to transmit electrical energy to the right ventricle. Further, additional inward facing bumper tabs 32 are present to catch, drag, stick to, or pull on adjacent anatomical structures to keep the epicardial pacing catheter 10 from moving.
LV left ventricle
LA left atrium
RA right atrium
RV right ventricle
both the number of inward facing friction tabs 32 and outward facing bumper tabs 31 may vary as desired or required to stabilize the epicardial pacing catheter 10 .
inward facing friction tabs 32 may be located proximal or distal to any outward facing bumper tab 31 .
outward facing bumper tabs 31 may be located proximal or distal to any inward facing friction tab 32 .
outward facing bumper tabs 31 and inward facing friction tabs 32 may be positioned at the same location on the epicardial pacing catheter 10 as desired or required.
each electrode 43 could be turned on separately in a unipolar or bipolar fashion, allowing for pacing of different chambers and different parts of the same chamber at different times. This has an important advantage: if a region of tissue ever dies in heart attack, pacing can be accomplished from a different location.
inward facing friction tabs and outward facing bumper tabs may be alternated with one another, be staggered with one another, or grouped in numbers among each other as desired or required according to medical procedures, device/system operations and anatomical considerations.
FIGS. 6(A)-6(F) schematically illustrate cross sectional views of an exemplary embodiment of the epicardial pacing catheter 10 of the epicardial pacing system from the most distal end to a more proximal point.
FIG. 6(A) schematically illustrates a cross sectional view of an exemplary embodiment of the most distal portion of the epicardial pacing catheter 10 of the epicardial pacing system.
the epicardial pacing catheter 10 further comprises a fluid lumen 61 .
the fluid lumen occupies internal cross-sectional area of the epicardial pacing catheter 10 .
the fluid lumen 61 may extend from an aperture (not shown) in the proximal end of the catheter 10 to a distal fluid aperture 55 . Both the distal fluid aperture 55 and a proximal fluid aperture (not shown) are adapted for the emitting and extracting of a fluid, drug, or agent.
the fluid, drug, or agent may be used, but is not necessarily used, to cool the electrodes 43 , regulate heart activity, or distend proximal anatomical structures.
the proximal fluid aperture (not shown) is connected to an external fluid, drug, or agent source (not shown).
the emitting and extracting of a fluid, drug, or agent may be controlled by an external control handle 150 (as shown, for example, in FIG. 15 ) in communication with the proximal end and fluid, drug, or agent source.
the fluid, drug, or agent to flow through the epicardial pacing catheter 10 may be at least one of the following: agent, substance, material, saline solutions, thrombolytic agents, clot lysis agents, chemotherapies, cell slurries, gene therapy vectors, growth factors, contrast agents, angiogenesis factors, radionuclide slurries, anti-infection agents, anti-tumor compounds, receptor-bound agents and/or other types of drugs, therapeutic agent and/or diagnostic agent or any combination thereof.
FIG. 6(B) schematically illustrates a more proximal cross section of an example embodiment of the epicardial pacing catheter 10 of the epicardial pacing system located proximal to the distal point of curvature 41 .
Both the first distal steering pull-wire 68 and second distal steering pull-wire 69 occupy internal cross-sectional area of the epicardial pacing catheter 10 and extend longitudinally to the most proximal portion of said catheter 10 .
the first distal steering pull-wire 68 and second distal steering pull-wire 69 may be controllably connected to a control means (as shown, for example, in FIG. 15 ) in communication with the proximal portion of the epicardial pacing catheter 10 .
the epicardial pacing catheter 10 may further comprise a stabilization means.
the stabilization means may be deployable and may comprise an inward facing friction tab 32 , an outward facing bumper tab 31 , a non-deployable protrusion, a screw, a hook, or other means known in the art.
a tab deployment rod 64 extends longitudinally from the most proximal portion of the epicardial pacing lead 10 to the most distal inward facing friction tab 32 or outward facing bumper tab 31 .
the tab deployment rod 64 may be a longitudinal structure, such as, but not limited to, a push-rod, pull-rod, wire, string, or rope.
the tab deployment rod 64 made be made of a non-conductive material having high tensile strength as is known in the art.
the tab deployment rod 64 may further be controllably connected to a control means (as shown, for example, in FIG. 15 ) in communication with the epicardial pacing catheter 10 , said control means used to control the deployment of the stabilization means.
the tab deployment rod 64 is in communication with a number of tab deployment arms 65 , wherein each tab deployment arm 65 can be actuated to deploy the inward facing friction tab 32 or outward facing bumper tab 31 .
FIG. 6(C) schematically illustrates a more proximal cross section of an exemplary embodiment of the epicardial pacing catheter 10 of the epicardial pacing system.
the anode wire 62 extends longitudinally from the most proximal portion of the epicardial pacing catheter 10 to the most distal anode 63 .
the anode wire 62 may be in communication with one or more anodes 63 located throughout the epicardial pacing catheter 10 . Further, the anode wire 62 is adapted for transmitting and receiving electrical energy.
the anode wire 62 may be controllably connected to a control means (as shown, for example, in FIG. 15 ) in communication with the proximal portion of the epicardial pacing catheter 10 .
An outward facing bumper tab 31 is shown in communication with the epicardial pacing catheter 10 .
the outward facing bumper tab 31 may be deployed by a tab deployment arm 65 in communication with the tab deployment rod 64 .
FIG. 6(D) schematically illustrates a more proximal cross section of an exemplary embodiment of the epicardial pacing catheter 10 of the epicardial pacing system located proximal to the proximal point of curvature 42 .
the epicardial pacing catheter 10 further comprises a second steering means.
the second steering means comprises a first proximal steering pull-wire 70 and a second proximal steering pull-wire 71 . Both the first proximal steering pull-wire 70 and second proximal steering pull-wire 71 occupy internal cross-sectional area of the epicardial pacing catheter 10 and extend longitudinally to the most proximal portion of said catheter 10 .
the first proximal steering pull-wire 70 and second proximal steering pull-wire 71 may be controllably connected to a control means (as shown, for example, in FIG. 15 ) in communication the proximal portion of the epicardial pacing catheter 10 .
FIG. 6(E) schematically illustrates a more proximal cross section of an example embodiment of the epicardial pacing catheter 10 of the epicardial pacing system.
a cathode wire 66 extends longitudinally from the most proximal portion of the epicardial pacing catheter 10 to the most distal cathode 67 .
the cathode wire 66 may be in communication with one or more cathodes 67 located throughout the epicardial pacing catheter 10 . Further, the cathode wire 66 is adapted for transmitting and receiving electrical energy.
the cathode wire 66 may be controllably connected to a control means (as shown, for example, in FIG. 15 ) in communication with the proximal portion of the epicardial pacing catheter 10 .
FIG. 6(F) schematically illustrates a more proximal cross section of an example embodiment of the epicardial pacing catheter 10 of the epicardial pacing system.
An outward facing bumper tab 31 is shown in communication with the epicardial pacing catheter 10 .
the outward facing bumper tab 31 may be deployed by a tab deployment arm 65 in communication with a tab deployment rod 64 .
the number of port holes, lumens, wires or rods may vary as may be desired or required according to medical procedures, device/system operations and anatomical considerations.
FIGS. 7(A) and 7(B) schematically illustrate a cross sectional view of an exemplary embodiment of the proximal end 73 of the epicardial pacing catheter 10 of the epicardial pacing system and the most distal end 74 of the control means 150 respectively.
twelve electrode wires including six anode wires 62 and six cathode wires 66 , occupy internal cross-sectional area of the epicardial pacing catheter 10 .
Each anode wire 62 and cathode wire 66 extends longitudinally through the epicardial pacing catheter 10 towards the distal portion.
the cathode wire 66 may be in communication with one or more cathodes 67 located throughout the epicardial pacing catheter 10 .
the anode wire 62 may be in communication with one or more anodes 63 located throughout the epicardial pacing catheter 10 .
any number of electrodes 43 may be present as desired or required to pace a number of locations on the heart of a patient.
a single anode wire 62 may be used to provide electrical energy to a multitude of anodes 63 , or each anode wire 62 can provide electrical energy to a single anode 63 .
a single cathode wire 66 may be used to provide electrical energy to a multitude of cathodes 67 , or each cathode wire 66 can provide electrical energy to a single cathode 67 .
electrical energy can be transmitted to each electrode 43 separately in a unipolar or bipolar fashion, allowing for pacing of different chambers and different parts of the same chamber at different times.
first proximal steering pull-wire 70 , first distal steering pull-wire 68 , second proximal steering pull-wire 71 , and second distal steering pull-wire 69 occupy internal cross-sectional area of the epicardial pacing catheter 10 .
Each first proximal steering pull-wire 70 , first distal steering pull-wire 68 , second proximal steering pull-wire 71 , and second distal steering pull-wire 69 extends longitudinally through the epicardial pacing catheter 10 towards the distal portion.
Each first proximal steering pull-wire 70 , first distal steering pull-wire 68 , second proximal steering pull-wire 71 , and second distal steering pull-wire 69 may comprise guidewires, tensioning lines, pull strings, digitating distal tips, magnetic guidance means, wires, rods, chains, bands, chords, ropes, string tubes, filaments, threads, fibers, strands, other extended elements, or any other method known in the art.
first tab deployment rod 64 and second tab deployment rod 72 occupy internal cross-sectional area of the epicardial pacing catheter 10 .
Each first tab deployment rod 64 and second tab deployment rod 72 extends longitudinally from the most proximal portion 73 of the epicardial pacing lead 10 to the most distal inward facing friction tab 32 or outward facing bumper tab 31 .
the first tab deployment rod 64 and second tab deployment rod 72 may comprise a longitudinal structure, such as, but not limited to, a push-rod, pull-rod, wire, string, magnetic guidance means, chains, bands, chords, or rope.
the first tab deployment rod 64 and second tab deployment rod 72 may comprise a non-conductive material having high tensile strength as is known in the art.
the first tab deployment rod 64 and second tab deployment rod 72 may further be controllably connected to the distal end 74 of a control means 150 in communication with the proximal end 73 of the epicardial pacing catheter 10 , said control means used to control the deployment of the tabs.
first tab deployment rod 64 and second tab deployment rod 72 are shown, any number of tab deployment rods may be present as desired or required, up to an including the sum of inward facing friction tabs 32 and outward facing bumper tabs 31 (See FIGS. 6 (A)-(E)).
a biocompatible cover may be in communication with the most proximal end 73 of the epicardial pacing catheter 10 .
the biocompatible cover may prevent fibrosis from occurring around the exposed structures of the epicardial pacing catheter 10 .
the proximal end 73 of the epicardial pacing catheter 10 may be located just under the skin of a patient.
the proximal end 73 can be reached by a non-surgical, minimally-invasive incision of the skin, carried out by a clinician or cardiologist.
proximal end 73 may protrude from said proximal end 73 of the epicardial pacing catheter 10 .
the proximal end 73 could act as a male connector in a male-female connection. It should be appreciated that the corresponding male-female connection may be reversed as well.
FIG. 7(B) shows a cross sectional view of an example embodiment of the most distal portion 74 of a control handle 150 .
the control handle 150 can be controllably connected to the most proximal portion 73 of the epicardial pacing catheter 10 .
Wire grippers 75 around each of the internal structures facilitate a secure connection between structures integral the control handle 150 and structures integral the epicardial pacing catheter 10 .
all structures within the control handle 150 may end before the distal end 74 .
the distal end 74 can act as a female connector in a male-female connection.
FIGS. 8 (A)-(C) schematically illustrate cross-sectional views of an example embodiment wherein the epicardial pacing catheter 10 further comprises a stabilization means for stabilizing the epicardial pacing catheter 10 .
the stabilization means may comprise at least one deployable member.
the stabilization means allows the rotational orientation of the distal portion of the epicardial pacing catheter 10 to remain fixed in place relative to the surface of the heart. If the distal portion of the epicardial pacing catheter 10 were allowed to rotate so that the electrodes 43 faced away from the heart, pacing could not be achieved and adjacent anatomical structures would receive harmful electronic energy.
FIGS. 8 (A)-(C) illustrate an exemplary embodiment wherein the stabilization means is an inward facing friction tab 32 .
the inward facing friction tab 32 comprises a catheter-side surface 82 and an anatomical-side surface 83 .
the anatomical-side surface 83 comprises a lubricious surface that may be navigated through anatomical structures without sticking or catching.
the catheter-side surface 82 comprises a rough surface having a larger coefficient of friction than the anatomical-side surface.
the catheter-side surface may further comprise a textured surface to increase friction.
Both the catheter-side surface 82 and anatomical-side surface 83 comprise a non-conductive material, such as, but not limited to polyurethane, Teflon, silicone, a radio-opaque material, or similarly lubricious material, or other materials known in the art.
a non-conductive material such as, but not limited to polyurethane, Teflon, silicone, a radio-opaque material, or similarly lubricious material, or other materials known in the art.
FIG. 8(A) illustrates an exemplary embodiment wherein the stabilization means further comprises a stabilizer actuator, wherein said stabilizer actuator deploys the inward facing friction tab 32 .
the stabilizer actuator is illustrated as a tab deployment rod 64 in communication with a tab joint 84 , tab hinge 81 , and tab deployment arm 65
the stabilizer actuator may comprise any longitudinal member in communication with at least one of the following: gear, hinge, joint, rack and pinion, pulley, linear actuator, or linear-rotational actuator, or any combination thereof.
the longitudinal member may be, for example, a push-rod, pull-wire, wire, string, rope, pole, thread, filament, cord, strand or other means known in the art.
the stabilizer actuator may further comprise a micro electrical mechanical system (MEMS).
MEMS micro electrical mechanical system
a tab deployment rod 64 extends longitudinally from the most proximal portion of the epicardial pacing lead 10 to the most distal inward facing friction tab 32 .
the tab deployment rod 64 may be a longitudinal structure, such as, but not limited to, a push-rod, pull-rod, wire, string, pole, thread, filament, cord, strand or rope.
the tab deployment rod 64 made be made of a non-conductive material having high tensile strength as is known in the art.
the tab deployment rod may further be controllably connected to a control means or control handle (as shown, for example, in FIG. 15 ) in communication with the epicardial pacing catheter 10 of the epicardial pacing system 5 , and the control means may be used to control the deployment of the tabs.
the tab deployment rod 64 is in communication with a tab joint 84 , the tab joint 84 in connection with a tab deployment arm 65 having its endpoint within the inward facing friction tab 32 .
the tab deployment arm is in further communication with a tab hinge 81 .
the epicardial pacing catheter 10 When the inward facing friction tab 32 is in the non-deployed state, the epicardial pacing catheter 10 may be moved, navigated, or slid within the middle mediastinum. In this way, the epicardial pacing catheter 10 can be inserted, placed, navigated or removed from the pericardial sack.
FIG. 8(B) illustrates an embodiment wherein the stabilization means is an inward facing friction tab 32 in the partially-deployed state.
the tab deployment rod 64 When the tab deployment rod 64 is pushed toward the distal end of the epicardial pacing catheter 10 , the tab deployment arm 65 is pulled or tensioned. This causes the inward facing friction tab 32 to separate from the catheter body, exposing the rough catheter-side 82 to proximate anatomical structures.
FIG. 8(C) illustrates an embodiment wherein the stabilization means is an inward facing friction tab 32 in the fully-deployed state.
outward facing bumper tabs 31 may be deployed using the same means and methods as described above.
the stabilization means may comprise one or more protrusions for engaging proximal anatomical structures such as the pericardium and/or the epicardium.
the protrusions may be non-deployable.
the protrusions may comprise a non-conductive material, such as, but not limited to, silicone, polyurethane, Teflon, a radio-opaque material, or other materials known in the art.
hinge devices and joint devices may be a number of elements such as, but not limited thereto, a fulcrum, swivel, gear, elbow, pivot, thrust or the like.
tab devices may be a number of elements such as, but not limited thereto, finger, stud, post, tongue, spring, projection, pin, pedestal, extension, offset, knob, protuberance or the like.
FIG. 9 schematically illustrates an example embodiment of the epicardial pacing catheter 10 of the epicardial pacing system in relation to the heart 21 and further comprising at least one deployable member.
the epicardial pacing catheter 10 has been steered around its distal point of curvature 41 , and is positioned in the pericardial space, cavity or sack 24 , or the area between the pericardium 22 and epicardium 23 .
the deployable member comprises at least one electrode 43 , and each electrode 43 is facing the heart 21 .
the electrodes 43 may be deployed from the epicardial pacing catheter 10 and are fixed to the epicardium 23 when in the fully-deployed state.
the epicardial pacing catheter 10 may further comprises an insulating hood 101 in communication with the epicardial pacing catheter 10 .
FIG. 10(A) schematically illustrates a top view of an example embodiment of the epicardial pacing catheter 10 of the epicardial pacing system.
the epicardial pacing catheter further comprises a insulating hood 101 extending from beyond the distal point of curvature 41 to a distal tip 51 .
the hood may serve as a cushioning and/or alignment means for the distal tip 51 relative to adjacent anatomical structures. It should be appreciated that some portion of the distal tip shall have insulation to protect from adjacent anatomical structures.
the shape of the distal tip and hood may vary according to medical procedures, device/system operations and anatomical considerations.
FIG. 10(B) schematically illustrates a bottom view of an exemplary embodiment of the epicardial pacing catheter 10 of the epicardial pacing system.
An anode 63 and cathode 67 are shown in communication with the epicardial pacing catheter 10 .
the contact zones containing the anode 63 and cathode 67 electrodes are about 2 mm in length and about 1 mm in width, and are located centrally within the underside surface of the insulating hood 101 . It should be appreciated that the width of the electrodes may be longer or shorter as may be desired or required according to medical procedures, device/system operations and anatomical considerations.
the insulating hood extends from a distal location beyond the distal point of curvature 41 to a distal tip 51 .
FIG. 10(C) schematically illustrates an axial view of an exemplary embodiment of the epicardial pacing catheter 10 of the epicardial pacing system looking at the distal tip 51 of the insulating hood 101 .
a single electrode 43 can be seen on the underside of the epicardial pacing catheter 10 .
FIG. 10(D) schematically illustrates a side view of an exemplary embodiment of the epicardial pacing catheter 10 comprising an insulating hood 101 , distal tip 51 , and two electrodes 43 .
the insulating hood 101 extends over the side of the epicardial pacing catheter 10 .
each electrode 43 could be powered separately in a unipolar or bipolar fashion, allowing for pacing of different parts of the same chamber at different times.
FIG. 11(A)-11(E) schematically illustrate cross sectional views of an exemplary embodiment of the epicardial pacing catheter 10 of the epicardial pacing system from a point located proximal to the most distal anode 62 or cathode 67 and distal to the distal point of curvature 41 to a point located at the most proximal point 73 of the epicardial pacing catheter 10 .
FIG. 11(F) schematically illustrates a cross sectional view of an exemplary embodiment of the external control handle 150 at the most distal point 74 .
FIG. 11(A) schematically illustrates a cross section of an example embodiment of the epicardial pacing catheter 10 located more distal than the distal point of curvature 41 and proximal to the most distal anode 62 or cathode 67 .
An anode wire 62 , cathode wire 66 , electrode pull-wire 112 , and second-electrode pull-wire 113 occupy internal cross-sectional area of the epicardial pacing catheter 10 and extend longitudinally to the most proximal portion 73 of said catheter 10 .
the anode wire 62 , cathode wire 66 , electrode pull-wire 112 , and second-electrode pull-wire 113 may comprise longitudinal structures, such as, but not limited to, push-rods, pull-rods, wires, strings, or ropes. Further, the anode wire 62 , cathode wire 66 , electrode pull-wire 112 , and second-electrode pull-wire 113 may be controllably connected to a control handle 150 in electrical communication with the most proximal point 73 of the epicardial pacing catheter 10 .
the anode wire 62 and electrode pull-wire 112 extend longitudinally from the most proximal portion 73 of the epicardial pacing catheter 10 to the most distal anode 63 .
the cathode wire 66 and second electrode pull-wire 113 extend longitudinally from the most proximal portion 73 of the epicardial pacing catheter 10 to the most distal cathode 67 .
FIG. 11(B) schematically illustrates a more proximal cross section of an example embodiment of the epicardial pacing catheter 10 located at the distal point of curvature 41 .
the epicardial pacing catheter 10 further comprises a first distal steering pull-wire 68 and a second distal steering pull-wire 69 fixed to distal steering anchors 110 in communication with the epicardial pacing catheter 10 .
the distal steering anchors 110 comprise a material with requisite strength to hold the first distal steering pull-wire 68 and second distal steering pull-wire 69 in place.
the first distal steering pull-wire 68 and second distal steering pull-wire 69 occupy internal cross-sectional area of the epicardial pacing catheter 10 and extend longitudinally to the most proximal point 73 of said catheter 10 .
the first proximal steering pull-wire 68 and second proximal steering pull-wire 69 may be controllably connected to a control handle 150 in communication with the most proximal point 73 of the epicardial pacing catheter 10 .
FIG. 11(C) schematically illustrates a more proximal cross section of an example embodiment of the epicardial pacing catheter 10 located between the distal point of curvature 41 and proximal point of curvature 42 .
FIG. 11(D) schematically illustrates a more proximal cross section of an example embodiment of the epicardial pacing catheter 10 located at the proximal point of curvature 42 .
the epicardial pacing catheter 10 further comprises a proximal steering pull-wire 70 fixed to a proximal steering anchor 111 in communication with the epicardial pacing catheter 10 .
the proximal steering anchor 111 comprises a material with requisite strength to hold the proximal steering pull-wire 70 .
the proximal steering pull-wire 70 occupies internal cross-sectional area of the epicardial pacing catheter 10 and extends longitudinally to the most proximal point 73 of said catheter 10 .
the proximal steering pull-wire 70 can be controllably connected to a control handle 150 or control means in communication with the most proximal point 73 of the epicardial pacing catheter 10 .
FIG. 11(E) schematically illustrates a more proximal cross section of an example embodiment of the epicardial pacing catheter 10 located at the most proximal point 73 .
anode wire 62 electrode pull-wire 112 , cathode wire 66 , and second electrode pull-wire 113 are shown, any number of anode wires 62 , electrode pull-wires 112 , cathode wires 66 , and second electrode pull-wires 113 may be present as desired or required, up to and including, for example, the total number of electrodes 43 (or the sum of the anodes 63 and cathodes 67 ).
a biocompatible cover may be in communication with the most proximal end 73 of the epicardial pacing catheter 10 .
the biocompatible cover can prevent fibrosis from occurring around the exposed wires of the epicardial pacing catheter 10 .
the proximal end 73 of the epicardial pacing catheter 10 is located just under the skin of a patient (or location(s) as desired or required).
the proximal end 73 can be reached by a non-surgical, minimally-invasive incision of the skin, carried out by a clinician or cardiologist.
all structures beginning at the proximal end 73 may protrude from said proximal end 73 of the epicardial pacing catheter 10 .
the proximal end 73 could act as a male connector in a male-female connection.
the male-female arrangement may be reversed if desired or required.
FIG. 11(F) schematically illustrates a cross sectional view of an example embodiment of the most distal portion 74 of a control handle 150 .
the control handle 150 can be controllably connected to the most proximal portion 73 of the epicardial pacing catheter 10 .
Wire grippers 75 (or other retention means or devices) around each of the internal structures facilitate a secure connection between structures integral the control handle 150 and structures integral the epicardial pacing catheter 10 .
control handle or control means may end before the distal end 74 .
distal end 74 can act as a female connector in a male-female connection (or female-male connection).
FIG. 12(A) schematically illustrates a cross section of an exemplary embodiment of the epicardial pacing catheter 10 of the epicardial pacing system comprising a deployable stabilization means in an un-deployed state.
the deployable stabilization means comprises an anode 63 and cathode 67 in communication with a hook 124 .
the hook 124 , anode 63 , and cathode 67 comprise conductive materials, such as, but not limited to, copper, platinum, gold, silver or iridium, and/or alloys thereof.
the stabilization means further comprises a stabilizer actuator, wherein said stabilizer actuator deploys the anode 63 and cathode 67 in communication with the hooks 124 .
the stabilizer actuator is illustrated as an electrode pull-wire 112 in communication with a joint 121 , and hinge 122 , the stabilizer actuator may comprise any longitudinal member in communication with at least one of the following: gear, hinge, joint, rack and pinion, pulley, linear actuator, or linear-rotational actuator, or any combination thereof.
the longitudinal member may be, for example, a push-rod, pull-wire, wire, string, rope, pole, thread, filament, cord, strand or other means known in the art.
the stabilizer actuator may further comprise a micro electrical mechanical system (MEMS).
MEMS micro electrical mechanical system
hook devices may be a number of elements such as, but not limited thereto, pin, claw, latch, finger, stud, spring, post, tongue, projection, pin, pedestal, extension, offset, knob, protuberance or the like.
an electrode pull-wire 112 extends longitudinally from the most proximal portion of the epicardial pacing lead 10 to the most distal electrode 43 , which may comprise an anode 63 or cathode 67 .
the electrode pull-wire 112 is in communication with a joint 121 , the joint 121 in further communication with a hinge 122 .
the electrode pull-wire 112 may comprise a conductive material having high tensile strength as is known in the art.
the electrode-pull wire 112 may further be controllably connected to a control means (for example, as shown in FIG. 15 ) in communication with the epicardial pacing catheter 10 and epicardial pacing system.
the control means may be used to control the deployment of the anode 63 and cathode 67 in communication with hooks 124 , and any of the devices, systems, subsystems, elements, and devices discussed throughout this disclosure.
the epicardial pacing catheter 10 further comprises an insulating distal tip 51 in communication with the epicardial pacing catheter.
the epicardial pacing catheter 10 further comprises a number of bumpers 120 in communication with the bottom of the epicardial pacing catheter 10 .
the bumpers enable the epicardial pacing catheter 10 to sit on the surface of the heart in a non-deployed state without allowing the anode 63 or cathode 67 to be in communication with the epicardium.
the epicardial pacing catheter 10 When the deployable anode 63 and cathode 67 are in the non-deployed state, the epicardial pacing catheter 10 may be moved or navigated within the middle mediastinum. In this way, the epicardial pacing catheter 10 can be inserted, placed, navigated or removed from the pericardial sack.
FIG. 12(B) schematically illustrates a cross section of an exemplary embodiment of the epicardial pacing catheter 10 comprising a deployable anode 63 and cathode 67 in a fully-deployed state.
the electrode pull-wire 112 is pushed toward the distal end of the epicardial pacing catheter 10 , the anode 63 and cathode 67 are splayed outward to a 90 degree angle, or an angel(s) as desired or required. This causes the anode 63 and cathode 67 to separate from the catheter body, allowing the hooks 124 to engage proximate anatomical structures, such as the epicardial wall.
the rotational orientation of the distal portion of the epicardial pacing catheter 10 remains fixed in place relative to the surface of the heart. If the distal portion of the epicardial pacing catheter 10 were allowed to rotate so that the electrodes 43 faced away from the heart, pacing could not be achieved and adjacent anatomical structures would receive harmful electronic energy.
any number of deployable electrodes 43 may be present as desired or required to pace any number of locations on the heart of a patient.
FIG. 13(A) schematically illustrates a cross section of an exemplary embodiment of the epicardial pacing catheter 10 of the epicardial pacing system comprising a deployable stabilization means in an un-deployed state.
the deployable stabilization means comprises a number of screws 130 in communication with an anode 63 and cathode 67 .
the screws 130 , anode 63 , and cathode 67 comprise conductive materials, such as, but not limited to, copper, platinum, gold, silver and/or iridium, and/or alloys thereof.
the stabilization means further comprises a stabilizer actuator, wherein said stabilizer actuator deploys the screws 130 in communication with the anode 63 and cathode 67 .
the stabilizer actuator is illustrated as an electrode pull-wire 112 in communication with a gear 131
the stabilizer actuator may comprise any longitudinal member in communication with at least one of the following: gear, hinge, joint, rack and pinion, pulley, linear actuator, or linear-rotational actuator, or any combination thereof.
the longitudinal member may be, for example, a push-rod, pull-wire, wire, string, rope, pole, thread, filament, cord, strand, or other means known in the art.
the stabilizer actuator may further comprise a micro electrical mechanical system (MEMS).
MEMS micro electrical mechanical system
screw devices may comprise a number of elements such as, but not limited thereto, any translatable protrusion or extension for instance.
Some non-limiting examples may include: toggle, press, slide, spring, stud, post, tongue, projection, pedestal, protuberance, contact, or the like.
an electrode pull-wire 112 extends longitudinally from the most proximal portion of the epicardial pacing lead 10 to the most distal electrode 43 , which may be an anode 63 or cathode 67 .
the electrode pull-wire 112 may be a longitudinal structure, such as, but not limited to, a push-rod, pull-rod, wire, string, or rope.
the electrode pull-wire 112 may be made of a conductive material having high tensile strength as is known in the art.
the electrode-pull wire 112 may further be controllably connected to a control means (as shown, for example, in FIG. 15 ) in communication with the epicardial pacing catheter 10 and epicardial pacing system.
the control means may be used to control the deployment of the screws 130 in communication with the anode 63 and cathode 67 .
the epicardial pacing catheter 10 further comprises an insulating distal tip 51 in communication with the epicardial pacing catheter.
the epicardial pacing catheter 10 When the screws 130 are in the non-deployed state, the epicardial pacing catheter 10 may be moved or navigated within the middle mediastinum. In this way, the epicardial pacing catheter 10 can be inserted, placed, navigated, translated, rotated or removed from the pericardial sack.
FIG. 13(B) schematically illustrates a cross section of an exemplary embodiment of the epicardial pacing catheter 10 comprising fully-deployed screws 130 in communication with the anode 63 and cathode 67 .
the gears 131 are activated and the screws 130 are rotationally-actuated. This causes the screws 130 to engage proximate anatomical structures, such as the epicardial wall.
the rotational orientation of the distal portion of the epicardial pacing catheter 10 remains fixed in place relative to the surface of the heart.
the electrical energy is transmitted from the anode 63 and cathode 67 through the screws 130 and into the heart.
any number of deployable screws 130 may be present as desired or required to pace any number of locations on the heart of a patient.
FIG. 14(A) schematically illustrates a cross section of an exemplary embodiment of the epicardial pacing catheter 10 epicardial pacing system comprising a deployable stabilization means in an un-deployed state.
the deployable stabilization means comprises an anode 63 and cathode 67 in communication with a hook 124 .
the hooks 124 , anode 63 , and cathode 67 comprise conductive materials, such as, but not limited to, copper, platinum, gold, silver and/or iridium, or alloys thereof.
the deployable stabilization means further comprises a stabilizer actuator, wherein said stabilizer actuator deploys the anode 63 and cathode 67 in communication with the hooks 124 .
the stabilizer actuator is illustrated as an electrode pull-wire 112 and second electrode pull-wire 113 in communication with a number of joints 121 , and hinges 122
the stabilizer actuator may comprise any longitudinal member in communication with at least one of the following: gear, hinge, joint, rack and pinion, pulley, linear actuator, or linear-rotational actuator, or any combination thereof.
the longitudinal member may be, for example, a push-rod, pull-wire, wire, string, thread, filament, cord, strand, rope, pole, or other means known in the art.
the stabilizer actuator may further comprise a micro electrical mechanical system (MEMS).
MEMS micro electrical mechanical system
an electrode pull-wire 112 and second electrode pull-wire 113 extend longitudinally from the most proximal portion of the epicardial pacing lead 10 to the most distal anode 63 and cathode 67 respectively.
the electrode pull-wire and second electrode pull-wire 113 are in communication with a number of joints 121 , the joints 121 in further communication with a number of hinges 122 .
the electrode pull-wire 112 and second electrode pull-wire 113 may comprise longitudinal structures, such as, but not limited to, push-rods, pull-rods, wires, thread, filament, cord, strand, strings, or ropes.
the electrode pull-wire 112 and second electrode pull-wire 113 may be made of a conductive material having high tensile strength as is known in the art.
the electrode-pull wire 112 and second electrode pull-wire 113 may further be controllably connected to a control means (for example, as shown in FIG. 15 ) in communication with the epicardial pacing catheter 10 and epicardial pacing system.
the control means may used to control the deployment of the anode 63 and cathode 67 in communication with hooks 124 .
the epicardial pacing catheter 10 further comprises an insulating distal tip 51 in communication with the epicardial pacing catheter.
the epicardial pacing catheter 10 may further comprise a number of bumpers 120 in communication with the epicardial pacing catheter 10 .
the bumpers 120 enable the epicardial pacing catheter 10 to sit on the surface of the heart in a non-deployed state without allowing the anode 63 or cathode 67 to communicate with the heart.
the epicardial pacing catheter 10 When the deployable anode 63 and cathode 67 are in the non-deployed state, the epicardial pacing catheter 10 may be moved or navigated within the middle mediastinum. In this way, the epicardial pacing catheter 10 can be inserted, placed, navigated, translated, rotated or removed from the pericardial sack.
FIG. 14(B) schematically illustrates a cross section of an exemplary embodiment of the epicardial pacing catheter 10 comprising a deployable anode 63 and cathode 67 in a fully-deployed state.
the electrode pull-wire 112 and second electrode pull-wire 113 are pulled toward the proximal end of the epicardial pacing catheter 10 , the anode 63 and cathode 67 are splayed outward to a 90 degree angle. This causes the anode 63 and cathode 67 to separate from the catheter body, allowing the hooks 124 to engage proximate anatomical structures, such as the epicardial wall.
the rotational orientation of the distal portion of the epicardial pacing catheter 10 remains fixed in place relative to the surface of the heart.
the electrical energy is transmitted from the anode 63 and cathode 67 through the hooks 124 and into the heart.
any number of deployable anodes 63 and cathodes 67 may be present as desired or required to pace any number of locations on the heart of a patient.
FIG. 15(A) schematically illustrates an example embodiment of an external control handle 150 (that may be associated with, although not shown, the epicardial pacing catheter of the system).
the epicardial pacing catheter and system further comprises a control means, wherein said control means is an external control handle 150 .
the external control handle 150 may be in communication with the most proximal point 73 of the epicardial pacing catheter 10 .
the external control handle 150 may have integral to it the distal steering control means 154 , the proximal control means 154 , the irrigation control means (not shown) and the control means for the stabilization means 151 .
the stabilization control means 154 may be used to regulate the degree of extension of said stabilization means via a pull-wire or pushrod arrangement or some other suitable tensioning or actuating means know in the art.
the external control handle 150 may further comprise a pull-rod control aperture 152 , wherein a tab deployment rod 64 and second tab deployment rod (not shown) may be inserted.
the external control handle 150 is preferably sized to be grasped, held and operated by a user. It should be appreciated that other control and operating interface members, devices, or means may be utilized for the handle. Attached to the proximal end of the control handle 150 is the handle proximal port (not shown) from which anode wires 62 and cathode wires 67 extend in order to make electrical connections to diagnostic or electrical devices (not shown). Electrical wires (for example, shown in FIGS. 6 , 7 , and 11 ) may extend through the proximal portion to each of the electrodes 43 of the epicardial pacing catheter 10 .
FIG. 15(B) schematically illustrates an example embodiment of the proximal steering control means 153 integral to the control handle 150 .
the proximal steering control means 153 is controllably connected to the first proximal steering pull-wire 70 and second proximal steering pull-wire 71 .
FIG. 15(C) schematically illustrates an example embodiment wherein the proximal steering control means 153 integral to the control handle 150 has been activated.
the proximal steering control means 153 is activated by a user, the first proximal steering pull-wire 70 becomes taught, and the second proximal steering pull-wire 71 loosens, creating slack 155 .
Both the first proximal steering pull-wire 70 and second proximal steering pull-wire 71 extend longitudinally through the control handle 150 , into the epicardial pacing catheter 10 , and are anchored at the proximal point of curvature 42 .
the epicardial pacing catheter bends toward the proximal steering anchor and around the proximal point of curvature 42 .
control handle may have channels for the steering pull wires and thumb wheel knobs for tightening or loosening the pull wires.
catheter device and epicardial system and their related components discussed herein may can take on all shapes along the entire continual geometric spectrum of manipulation of x, y and z planes to provide and meet the anatomical and structural demands and requirements.
Step 1 Access and place a guidewire in the pericardial space using our EpiNeedle Access system.
Step 2 Use a sheath, preferably our EpiSheath, or a general long 8 Fr sheath to place over the guidewire and maintain access.
Step 3 Place the lead of the subject invention with handle though the sheath.
Step 4 Guide the lead in the epicardial space using the two steering points and the sheath under fluoroscopic guidance (although this lead may be guided via one or more other imaging methods to include ICE, CT, MRI, Visual Endoscopy, or Echo Methods).
the lead should be advanced along the border of the heart apically to base along the LV. Once it crosses the AV groove to the LA it should be deflected downward and advanced through the transverse sinus. Once across the transverse sinus it will need to be deflected up to the SVC and then down to the RA and finally the RV.
Step 5 Segment the sheath back to the inferior portion of the RV.
Step 6 the handle should be hooked up to an EP analyzer.
the lead should be clocked for a more anterior position or counter-clocked for a more posterior position until the largest LV signals are found. If multi-chamber pacing is sought one should pick a point when at least two poles of the LV, and of each other chamber, has an amplitude of at least 1 mV in the atrium and 5 mV in the ventricle. Note there is no need for all points to have high amplitudes.
the tabs should be deployed. This should push the lead more tightly against the heart and actually increase the voltage. Then, pacing should be attempted in the LV. If threshold is less than 2.5 V it is a good site on any pole. The same should then be done with the other points. If no point is good the tab should be let down and then the lead repositioned.
Step 7 Once a good position is found the handle should be removed and the sheath withdrawn completely outside of the patient.
Step 8 The lead should be plugged into either a custom ICD/BiV or attached to our wire interface for a standard ICD.
the poles that are not used to pace should be plugged in this case.
all poles would be active and the user (or an automated system) may decide when to pace.
Step 9 The lead extender to the ICD would then either be tunneled back to the ICD in the shoulder (or elsewhere), placed by the nearby abdominal ICD. Or a battery-powered wireless box will be used to communicate with the main ICD in the shoulder. At this point the patient should be recovered. No stitch is needed for the lead access.
any activity can be repeated, any activity can be performed by multiple entities, and/or any element can be duplicated. Further, any activity or element can be excluded, the sequence of activities can vary, and/or the interrelationship of elements can vary. Unless clearly specified to the contrary, there is no requirement for any particular described or illustrated activity or element, any particular sequence or such activities, any particular size, speed, material, dimension or frequency, or any particularly interrelationship of such elements. Accordingly, the descriptions and drawings are to be regarded as illustrative in nature, and not as restrictive. Moreover, when any number or range is described herein, unless clearly stated otherwise, that number or range is approximate. When any range is described herein, unless clearly stated otherwise, that range includes all values therein and all sub ranges therein.

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Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
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Electrotherapy Devices (AREA)

US12/741,710 2007-11-09 2008-11-07 Steerable epicardial pacing catheter system placed via the subxiphoid process Abandoned US20100241185A1 (en)

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US12/741,710 US20100241185A1 (en)	2007-11-09	2008-11-07	Steerable epicardial pacing catheter system placed via the subxiphoid process

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US98678607P	2007-11-09	2007-11-09
US2372708P	2008-01-25	2008-01-25
PCT/US2008/082835 WO2009062061A1 (fr)	2007-11-09	2008-11-07	Système de cathéter de stimulation épicardiaque orientable placé via le processus sous-xiphoïde
US12/741,710 US20100241185A1 (en)	2007-11-09	2008-11-07	Steerable epicardial pacing catheter system placed via the subxiphoid process

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PCT/US2008/082835 A-371-Of-International WO2009062061A1 (fr)	2007-11-09	2008-11-07	Système de cathéter de stimulation épicardiaque orientable placé via le processus sous-xiphoïde

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US15/960,137 Active US11951303B2 (en)	2007-11-09	2018-04-23	Steerable epicardial pacing catheter system placed via the subxiphoid process

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Publication number	Publication date
US11951303B2 (en)	2024-04-09
US20180361145A1 (en)	2018-12-20
WO2009062061A1 (fr)	2009-05-14

Publication	Publication Date	Title
US11951303B2 (en)	2024-04-09	Steerable epicardial pacing catheter system placed via the subxiphoid process
US12397152B2 (en)	2025-08-26	Systems and methods for implanting a medical device
US10702335B2 (en)	2020-07-07	Electrode catheter for ablation purposes and related method thereof
CN102065781B (zh)	2014-05-07	导航和组织俘获系统
EP2291212B1 (fr)	2015-09-02	Cathéter de délivrance comprenant un orifice latéral et des électrodes
US9597514B2 (en)	2017-03-21	Epicardial heart rhythm management devices, systems and methods
CA2699536C (fr)	2019-08-20	Carte epicardiale et catheter d'ablation
CA2134904C (fr)	2000-01-25	Procede de cartographie par voie non chirurgicale et traitement de l'arythmie auriculaire au moyen de catheters guides par des introducteurs profiles
EP0745406B1 (fr)	2003-08-13	Cathéter pour le sinus coronaire
JP2018089431A (ja)	2018-06-14	カテーテル、カテーテルシステム、及び組織構造を刺通する方法
WO2007073435A1 (fr)	2007-06-28	Electrodes helicoidales pour une stimulation electrique et une détection intramyocardiques
CA2160510A1 (fr)	1996-05-12	Methode de traitement de l'arythmie auriculaire grace a un catheter guide par des dispositifs d'introduction mis en forme
JPH08299359A (ja)	1996-11-19	誘導導入器を用いた異所性心房性頻拍の非外科的マッピングおよび／または治療方法
US20100087725A1 (en)	2010-04-08	Novel Sheath and Electrical Lead
US12458798B2 (en)	2025-11-04	Implanting a lead in the internal thoracic vasculature
CN117797397A (zh)	2024-04-02	环扎心脏起搏器导线
US20040138651A1 (en)	2004-07-15	Pericardial maze procedure
JPH09173343A (ja)	1997-07-08	心房性不整脈の非外科的マッピングおよび治療用の形状付与された誘導導入器
JP2004275786A (ja)	2004-10-07	心房性不整脈の非外科的マッピングおよび治療用の形状付与された誘導導入器

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