US20090216204A1 - Auto-replenishing, wound-dressing apparatus and method - Google Patents

Auto-replenishing, wound-dressing apparatus and method Download PDF

Info

Publication number: US20090216204A1
Authority: US; United States
Prior art keywords: fluid; distribution member; dressing; active ingredient; distribution
Prior art date: 2008-02-27
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Abandoned

Application number

US12/341,832

Other languages

English (en)

Inventor

Sai Bhavaraju

Troy C. Dayton

John Howard Gordon

Jeremy Heiser

Ashok V. Joshi

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

APLION MEDICAL LLC

Original Assignee

APLION MEDICAL LLC

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2008-02-27

Filing date

2008-12-22

Publication date

2009-08-27

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40999026&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=US20090216204(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2008-12-22 Application filed by APLION MEDICAL LLC filed Critical APLION MEDICAL LLC

2008-12-22 Priority to US12/341,832 priority Critical patent/US20090216204A1/en

2009-06-11 Assigned to APLION MEDICAL, LLC reassignment APLION MEDICAL, LLC ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: BHAVARAJU, SAI, DAYTON, TROY C., GORDON, JOHN HOWARD, HEISER, JEREMY, JOSHI, ASHOK V.

2009-08-27 Publication of US20090216204A1 publication Critical patent/US20090216204A1/en

2014-06-16 Priority to US14/305,995 priority patent/US10279156B2/en

2019-01-11 Priority to US16/245,867 priority patent/US11497652B2/en

Status Abandoned legal-status Critical Current

Images

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/05—Bandages or dressings; Absorbent pads specially adapted for use with sub-pressure or over-pressure therapy, wound drainage or wound irrigation, e.g. for use with negative-pressure wound therapy [NPWT]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M35/00—Devices for applying media, e.g. remedies, on the human body
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M35/00—Devices for applying media, e.g. remedies, on the human body
- A61M35/003—Portable hand-held applicators having means for dispensing or spreading integral media
- A61M35/006—Portable hand-held applicators having means for dispensing or spreading integral media using sponges, foams, absorbent pads or swabs as spreading means
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F2013/00089—Wound bandages
- A61F2013/0017—Wound bandages possibility of applying fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F2013/00089—Wound bandages
- A61F2013/0017—Wound bandages possibility of applying fluid
- A61F2013/00174—Wound bandages possibility of applying fluid possibility of applying pressure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F2013/00089—Wound bandages
- A61F2013/00187—Wound bandages insulating; warmth or cold applying
- A61F2013/002—Wound bandages insulating; warmth or cold applying with temperature control
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F2013/00089—Wound bandages
- A61F2013/00246—Wound bandages in a special way pervious to air or vapours
- A61F2013/00268—Wound bandages in a special way pervious to air or vapours impervious, i.e. occlusive bandage

Definitions

This invention relates to treatment of skin defects, and in particular to control and delivery of treatment substances to a dressing on a skin defect.
Skin defects may be inflicted by people, machines, tools, vehicles, animals, plants, the environment, and many other factors. Likewise, pressure, ailments, infections, and disease may create sores, open wounds, and other skin defects. Skin defects may be treated by a variety of physical processes, materials, conditions, controls, and the like, each based on a particular theory, experiment, regimen, or other basis of justification. Meanwhile, skin defects may be characterized by their significance or seriousness, as well as their nature, their susceptibility to treatment, or the like. Skin defects maybe defined as wounds, incisions, or an injury to the body (as from trauma, pathology, or surgery) that typically involves laceration or breaking of a membrane (as the skin or mucous membrane) and usually damage to underlying tissues. Furthermore a wounds or skin defect may be characterized as minor, superficial, major, traumatic, acute, chronic, fatal, or the like.
Skin defects may require isolation from an environment, exposure to a particular environment, treatment by exposure to a medicament, covering, uncovering, and so forth.
a medicament such as an antiseptic, antibiotic, or the like in tincture or ointment form
a bandage or other covering may be applied to control or limit access to the skin defects by environmental agents (e.g. air, dirt, touching, etc.).
applying a medicament may only solve part of the problem. Changing a dressing, replenishing a quantity or concentration of a medicament, controlling the access, contact, and concentration of an active ingredient applied to skin defects, and verification of the foregoing are typically difficult to do. Application of a constant or even reliable or consistent concentration of a medicament is difficult to accomplish, even for a regularly attended patient.
a salve, ointment, cream, irrigation, tincture, or the like occurs at a point in time.
the dressing itself may soak up the medicament fluid, removing the contact with the skin defects. Drying of a carrier portion of a medicament fluid may inhibit chemical activity of an active ingredient by removing the necessary transport fluid required for migration, diffusion, or the like. Drying of tissues, blood, or serum may inhibit the action or effectiveness of an active ingredient, and may even block access by an active ingredient to underlying skin defect. Thus, finding a proper delivery mechanism to consistently, regularly, or constantly apply the right amount of a therapeutically effective active ingredient may be problematic in many instances.
a medicament fluid is applied as a salve, liquid, tincture, aspersion, cream, irrigation, or the like, the problem of the concentration of the active ingredient may actually render the application ineffective relatively quickly.
Many medicaments, once applied, have a rapidly decaying, uncontrolled, or ineffective concentration.
the concentration of an active ingredient in the bulk of a medicament fluid is necessarily much higher than the concentration migrating to the affected skin defect area.
the delivered concentration may become inappropriate.
Some dressings e.g. impregnated dressings deliver either below the therapeutic range or above it causing inadequate treatment or side effects and in the case of antibiotics possible resistance.
a method and system for consistent delivery over time of a specific volume, specific concentration and/or therapeutically effective concentration of an active ingredient of a beneficial fluid to the site of skin defect Also desirable would be supplying a specific volume, specific concentration and/or therapeutically effective concentration of a fresh active ingredient in a programmable manner to be within the therapeutic window to eliminate effects due to under delivery or over delivery. Also desirable is a method for maintaining a transport fluid (e.g. carrier, moisture, tissue moisture, etc.) available to support delivery of the active ingredient to the skin defect. It would be an advance in the art to provide a system and method to maintain a prescribed transport path, and effective concentration of fresh active ingredient to the site of the skin defect.
a transport fluid e.g. carrier, moisture, tissue moisture, etc.
an apparatus and method in accordance with the invention may include a fluid delivery system that includes a housing with reservoirs for a pressurization gas and sources for a medicament fluid.
the fluid may be loaded into a reservoir at a factory and sealed, or may be filled at the point of use through a valve, septum, or the like.
Filling the device at the point of use includes the ability to select from fluids containing a variety of appropriate fresh actives or combinations thereof.
Point of use or in situ filling has the added advantage of separating the shelf life and handling requirements of the device from the self life and handling requirements of the active. This may also be referred to as In situ filling.
the system of fluid delivery may include a housing having an inextensible interior volume to contain reservoirs and fluid sources in contact with one another.
a fluid source may have a wall flexible or otherwise able to move in response to pressure, being sealed to contain and maintain a fluid comprising an active ingredient disposed in a fluid carrier.
An inlet port such as a septum may provide sterile access to the fluid source to introduce the fluid.
An outlet port is provided for the fluid source to dispense the fluid.
a reservoir containing a gas moves at least one wall in response to pressure from gas output of a galvanic cell within or outside, but in communication with the reservoir.
An electric circuit may control current flow to control the rate of generation of gas.
the circuit may use a resistor and switch, a more sophisticated control circuit, or a microprocessor controller to control current and thus the gas generation rate.
the electrical circuit may be within the reservoir or within the housing or outside the housing. The electrical circuit may be controlled remotely or directly, by electrical, electromagnetic, magnetic, optical or mechanical means.
An outlet dispenses the fluid from the fluid source in response to displacement of its wall by the gas reservoir, sending the fluid through a feed conduit to a dressing.
the term conduit, feed conduit, feed line, and tubing may be used interchangeably throughout this disclosure.
the feed conduit may be as short or as long as desired, supporting placement of the pump nearby, or remote from, the dressing.
the feed conduit may include a restricted tube providing resistance to the fluid flow, thereby establishing back pressure within the fluid source. By selection of appropriate tubing and flow rate, a certain value of back pressure can be established within the fluid source.
the fluid delivery system may generate a gas into the gas reservoir having a movable wall.
the movable wall of the gas reservoir exerts pressure and displacement against a movable wall of the fluid source or reservoir, thus displacing the fluid.
the combination of the housing, gas reservoir, and fluid source may be configured as a pump or pump mechanism.
the displaced fluid may pass through a feed conduit to a dressing and ultimately to a skin defect to which the dressing is applied.
the dressing may include a distribution member which may be a wicking layer, a manifold of tubes with apertures, or a pouch with pores that allows the fluid to be distributed substantially uniformly irrespective of orientation of the dressing.
the distribution member maintains a fluid in the dressing and in contact with the skin defect being treated.
the fluid may be a transport fluid or carrier for conveying an active ingredient to the skin defect.
a connector positioned on the dressing connects the feed conduit to a distribution member portion of the dressing.
the connector may be advantageously positioned centrally on the dressing even though it may be anywhere on the dressing.
the distribution member may distribute the fluid there across, maintaining substantially even wetting across the domain irrespective of orientation of the dressing.
the fluid may saturate the wicking portion, thus making the fluid available to be in intimate contact with the skin defect.
the orientation independence of the wicking member may be accomplished by implementing various effects, including capillary action, hydrophobic/hydrophilic nature of the layer, surface tension optimization, composition, or texture and weave patterning of the layer, or the effects of evaporation. These effects individually or in combination are referred to “wicking action.”
the fluid may exit the feed conduit and into a manifold and exit substantially evenly through the apertures irrespective of orientation by maintaining a high fluid pressure in the manifold relative to barometric pressure.
the fluid may also be delivered substantially evenly through the pores in the pouch due to the comparatively high and uniform pressure across the plenum created by the pouch.
a specific volume, specific concentration and/or therapeutically effective concentration, or in other words a predetermined range of concentration, of the active ingredient may thus be available and in intimate contact with the skin defect, providing a transport fluid, active ingredient, constant rate, controllable and renewable concentration, and intimate contact.
manifold, header, arms, distribution tubes, tree structure, and plenum are used interchangeably throughout this specification.
the dressing may function effectively with any generic source other than the specific pump system described herein. Therefore, the source may be manual, such as a syringe, or any other delivery mechanism including gravity feed, mechanical pumping etc.
the source can supply fluid continuously, discontinuously, programmably, manually, or the like.
the dressing is configured to be cut to size, and still maintain the functional properties of the dressing. This will allow the dressing to be adaptable to the size of the skin defect.
the fluid may be configured as a liquid having an active ingredient dissolved within the liquid, or suspending as a micro-pulverized particulate, all disposed within a liquid having a viscosity selected to optimize a therapeutic effect a fluid may have a viscosity ranging from a very thick, honey-like substance, to a comparatively aqueous like, such as water or other liquid base.
a fresh active is a quality of material that remains substantially in its original state and has not been degraded.
a fresh active may also be provided in quantities that need not anticipate such degradation or change in the kinetics of delivery.
the terms fluid, fresh active, and medicament may be used in similar manners discernable by one schooled in the art.
a medicament maybe a fluid or it may be in some other form.
the active ingredient may be an agent having antimicrobial, antibiotic, analgesic, anti-inflammatory, hydrating, growth promotion, enzymatic debridement, antiseptic, irrigation, anesthetic, or emollient effect, and may be systemic, penetrating, or topical.
the fluid carrier of the fluid may be a liquid, gas, gel, sol, thixotropic, colloid, or other fluid, and may carry the active ingredient dissolved therein or suspended as particles in suspension.
the housing may be substantially rigid and made of metal, metal alloy, polymer, reinforced polymer, ceramic, or the like. Steel, stainless, brass, bronze, aluminum, titanium, and copper as well as olefinic, styrenic, polycarbonate, and elastomeric hydrocarbons may serve adequately.
the housing may be transparent to visible light, which may provide sight monitoring, but opacity may provide protection of the integrity of the fluid.
the housing may not be gas tight, but vented, thus allowing point of use filling of the fluid source or other actions expelling gas from the housing during operation.
Any reservoir or fluid source may have a pressure-relief mechanism, such as a vent or check valve, to regulate pressure, resist backflow, prevent rupture, or the like.
the fluid source may be filled by a syringe, through a valve or septum, and may be overfilled in order to prime the feed conduit, the dressing, or both prior to activation of the gas generator.
Reservoirs or fluid sources may be permanent or replaceable, single use or refillable, or the like.
the housing may be disposable or reusable, sealed, or openable.
the gas present in the reservoir may be vented at any time.
the fluid source may be pre-filled or filled at the point of use, and disposable or refillable. The point of use capability allows the user to select the suitable treatment among many options and greatly extends shelf life.
Gases from the gas generator may be any of those readily generated by electrochemical means.
hydrogen, oxygen, nitrogen, or carbon dioxide may be generated by galvanic cells without any need for external power.
the gas generator may include a galvanic cell completely contained within the gas reservoir.
the gas reservoir may be formed of a dielectric material to further insulate the electric circuit inside.
the circuit may be outside the reservoir or even outside the housing, but sealing may be easier if no penetrations are required in the wall or seams or the reservoir.
Actuation may be direct or remote, from a mechanical force, magnetic field, electric pulse, radio frequency signal, acoustic wave, or the like. Any activity of the apparatus may be indicated by an indicator identifying an “on” condition.
the feed conduit may be formed to be substantially inextensible, or may respond to pressure by including a pressure accumulator or simply an elastic portion to expand to ameliorate any sudden increase in pressure
an apparatus having a housing and a flexible reservoir and fluid source may have a selected fluid introduced as a fluid, and may be filled in a manner to prime the feed conduit, dressing, or both by injecting the fluid into the fluid source. Filling may pressurize the fluid source and force open a check valve, filling the feed conduit, and partially filling or saturating the dressing. Filling may also result in the initial pressurizing of the fluid source, expediting the need for the gas bag to do so and decreasing start up time.
the distribution member may be a manifold that distributes the fluid to various regions of the wick portion thereof. Tubes having perforations or orifices to resist flow may maintain a substantially equal pressure inside the distribution manifold. Sizes of path lengths, diameters, orifices, or the like may control pressure among outlets of tubes, plenums, pouches, bags, or the like to effect even distribution of the fluid.
a multi-member dressing may include a distribution member that may be a wicking layer receiving the fluid, a protective member that may or may not be configured to protect the dressing from the environment and provide for vapor transmission, a transfer or transport member to transfer the fluid to the wicking layer, a fluid absorber to absorb excessive fluid being delivered or for absorbing the wound exudate, a tenting member positioned at the rim of the dressing to provide for lateral evaporation, and an interface member between the wicking layer and the treated skin defect to transfer the fluid thereto from the wicking layer while performing any other function needed, such as anti-adhesion, or the like.
the dressing may comprise at least one functional member consisting of a distribution member, and additionally an interface member, transport member, barrier member, fluid absorber, any of said members could be integrated to achieve multiple functions in one or more members.
An interface member may be formed as a sheet, foam, gel, gauze, porous matrix, honeycomb, mop of fibrous material, comminuted fibrous material, nanotube composite structure, or the like, or any combination thereof.
the material thereof may be a biodegradable copolymer, dermal regeneration template, bioabsorbable gel, anti-adhesion polymer, skin substitute, moisture-retaining natural or synthetic composition, angiogenic composition, antimicrobial composition, or the like, or any combination thereof.
the carrier along with the active ingredient may be delivered directly to the skin defect. Alternatively the active alone may be transferred to the skin defect by diffusion or migration.
the current device allows maintenance of fluid balance in the skin defect under treatment. For example, moisture may be provided to the skin defect and excess moisture may be removed by vapor transmission or by an absorptive member.
the interface layer may also be referred to as the non adhering layer.
the distribution member material may be a polymer sheet, woven fabric, non-woven fabric, naturally occurring fiber, sponge, fiber matrix, gauze, absorbent material, adsorbent material, gel, foam, or the like, or any combination thereof.
Systems and methods in accordance with the foregoing may treat dermatological disorders, incisions or deeper wounds.
embodiments of systems and methods in accordance with the invention may be useful for delivering a fluid prescribed for a cut, laceration, scrape, allergy eruption, skin cancer, rash, burn, undesirable growth, cyst, wart, tumor, ulcer, boil, irritation, incision, trauma or the like.
a therapeutically effective concentration of an active ingredient may be delivered to the site of a disorder and delivered by intimate contact through the dressing.
a pore size in a wicking portion of a dressing may be selected evenly distribute the fluid carrier containing the active ingredient, independent from orientation.
the described apparatus for delivering fresh fluids to the skin defects may also be coupled with other well known wound treatments such as debridement, negative pressure wound therapy, phototherapy, surgical treatments, compression therapy, tissue replacement or the like.
the system is storage stable. Due to the stability of the mechanical and chemical systems, and the empty or closed nature of the mechanical systems, all may be stored for an extended period of time (e.g. months or years) before being put to use by point of use filling of the fluid source.
a pre-selected, therapeutically effective, threshold concentration may be prescribed.
the rate may be at a threshold value or in a range.
the control points for either a threshold value or a range may be selected, and the fluid delivered to effectively control pain, biotic growth, hydration, aeration, chemical reactions, biological process, or the like, or any suitable combination thereof.
a periodically, constantly, or programmatically delivered amount of a fluid into a dressing may maintain intimate contact, a transport fluid, and a controllable concentration of fresh active ingredient to a site of skin defect.
skin defect could be any dermatological disorder such as a wound, allergy eruption, skin cancer, rash, burn, undesirable growth, cyst, wart, tumor, ulcer, boil, irritation, incision, graft, oiliness, dryness, wrinkles, blemishes, discolorations, and trauma.
skin defect may be used interchangeably with any of these terms throughout the specification, depending upon the context in which the term is used.
FIG. 1 is a perspective view of one embodiment of a fluid delivery system for delivery of a fluid to a dressing for a skin defect;
FIG. 2 is a perspective view of various alternative embodiments of a pump configured for use in a fluid delivery system and method in accordance with the invention
FIG. 3 is a perspective view of various alternative embodiments of feed conduits for conducting a fluid from a pump in accordance with the invention
FIG. 4 is a perspective view of various configurations of a dressing for use in a fluid delivery system and method in accordance with the invention
FIG. 5 is a perspective view of various embodiments of distribution systems within a dressing in accordance with the invention.
FIG. 6 is a perspective view of one embodiment of a dressing in various orientations that may be occupied during service in accordance with the invention.
FIG. 7 is a perspective view of various members that may be consolidated to form a dressing in accordance with the invention.
FIG. 8 is a schematic diagram of a gas generator with various alternative embodiments on the controller therefore in accordance with the invention.
FIG. 9 is a side plan view of a cross-section of one embodiment of a housing and reservoir and fluid source system for a pump in accordance with the invention.
FIG. 10 is a perspective cutaway view of an alternative embodiment of a housing and enclosed reservoir and fluid source in accordance with the invention.
an apparatus 10 or system 10 in accordance with the invention may include a pump 12 operating as a delivery mechanism 10 for a fluid.
the fluid may typically be of a viscosity in a configuration suitable for pumping.
a fluid may be configured as a liquid having an active ingredient dissolved within the liquid, or suspending as a micro-pulverized particulate, all disposed within a liquid having a viscosity selected to optimize performance of the apparatus 10 .
the fluid or liquid operating within the pump 12 as a fluid may have a viscosity ranging from a very thick, honey-like substance, to a comparatively aqueous like viscosity, such as water or other liquid base.
the fluid may be a gel containing gelatin or other gelling agents in a liquid solution to stabilize that solution against separation, evaporation, or the like. Accordingly, a medicament or active ingredient may be dissolved in a liquid, and the liquid may be stabilized with a gelling agent.
the active ingredient may include at least one composition chosen from an antimicrobial, an antibiotic, an antifungal, an antiviral, an antiseptic, and an antibacterial agent.
the active ingredient may also include at least one composition chosen from an analgesic, a palliative, and an anti-inflammatory agent.
the active ingredient comprises at least one composition chosen from de-ionized water, a polymeric gel, a saline composition, and a hydrocolloid.
the active ingredient may comprise at least one beneficial agent chosen from an enzymatic debrider, a tissue growth factor, a scar-reducing agent, tissue cells, topical nutrients, a coagulant, nitric oxide, oxygen gas, ozone, and a gene therapy agent.
the active ingredient may be selected to be therapeutically effective in treating a dermatological disorder chosen from a skin defect, an allergy eruption, a skin cancer, a rash, a burn, a growth, a cyst, a wart, a tumor, an ulcer, a boil, an incision, a graft, oiliness, dryness, wrinkles, blemishes, discolorations, trauma, and numerous other maladies or conditions.
a dermatological disorder chosen from a skin defect, an allergy eruption, a skin cancer, a rash, a burn, a growth, a cyst, a wart, a tumor, an ulcer, a boil, an incision, a graft, oiliness, dryness, wrinkles, blemishes, discolorations, trauma, and numerous other maladies or conditions.
an apparatus or fluid delivery system 10 may operate to deliver a fluid through a feed conduit 14 extending a distance appropriate to service a dressing 16 .
the fluid delivery system 10 may include a housing 18 .
the housing 18 may be made of any suitable material and manufacturing method.
various polymers may be formed by methods such as vacuum forming, injection molding, blow molding, casting, or the like in various suitable shapes to have an interior cavity of suitable shape.
the housing 18 may be made in one or more parts.
the housing 18 may be opened like a clam shell.
the housing 18 may be formed as a single piece.
the housing 18 may be formed as a single piece having hinge portions and latch portions in order to close the housing 18 portions upon themselves in order to enclose the contents thereof.
the housing 18 may be formed as pieces, fabricated and assembled to be permanently closed.
the housing 18 may also be manufactured by stamping, die casting, centrifugal casting, investment casting, or other methods used in forming polymers or metals.
the housing 18 may be formed to have an opaque appearance on one or both sides or halves, or may have a translucent or even transparent appearance. In a transparent configuration, the housing 18 may provide visibility of a fluid therein. Thus, a quick, visual inspection may provide feedback on whether the amount or condition of the fluid is suitable. Likewise, any malfunction or abnormality of operation of the pump 12 may be readily visible within the housing 18 .
Polymer resins for injection molding may provide a comparatively lightweight and rigid structure for the housing 18 .
various stamped or die cast metal parts may also provide a robust, rigid, strong housing 18 for containing pressurized fluids in containers.
having a comparatively small aspect ratio of thickness to length or of thickness to height, in housing 18 may benefit from a comparatively thicker wall.
a sufficiently light and strong material and construction configuration are used for the housing 18 , an aspect ratio near unity may be appropriate as containment.
a hard, rigid housing 18 may provide protection against rupture or failure under the influence of accidental over-pressurization. This may be important in preventing an accidental bolus from being delivered due to crushing or compression of a compressible container within a compressible housing 18 .
a safety or control issue may not be a problem when a housing 18 is connected by a clip or magnet to a bed frame, medical IV stand, or the like. Then, a simple containment vessel of a sack type or wire frame type may suitably act as a housing 18 .
a housing 18 may be exposed to pressure by being placed on the bed or under the pillow of a patient or in a pocket of the clothing worn by a patient. Then, the dynamics may dictate the necessity of a rigid housing 18 capable of withstanding external pressures.
a gas generator 20 may provide an integrated source of gas to fill a reservoir 22 .
the gas generator 20 may include an electrochemical cell.
the fluid delivery system 10 includes a galvanic cell in communication with the reservoir and comprising a chemical selected to produce a gas within the reservoir 22 .
a galvanic cell in which a galvanic reaction occurs generating gas as a byproduct of the chemical reaction, is a suitable mechanism for a gas generator 20 .
a control circuit may be an integrated portion of the gas generator.
the gas generator 20 may be enclosed completely with the reservoir 22 , thus easing the need for complex or unreliable sealing procedures and materials. That is, sealing different materials or hard materials to flexible materials, or the like may sometimes be problematic. Likewise, over time, seals may deteriorate, separate, or otherwise fail.
a switch or controller may be imbedded. Access may be obtained by applying pressure to the switch or controller through the wall of the reservoir 22 , by pushing on it through an opening in the wall of the housing 18 . In such a manner, control of the gas generator 20 may be exercised within a sealed system of the reservoir 22 .
a switch mounted to a circuit board is sealed contiguously onto the face of the reservoir 22 in such a manner to maintain the gas tight property of the reservoir 22 .
the galvanic cell is enclosed in the reservoir 22 and the wires from the cell where connected to the circuit board positioned on the housing 18 wall allowing easy access to the circuit board.
An electrical conductor having various elements of control may run the galvanic cell to complete the circuit between the two reactant materials.
a controller may be connected to the galvanic cell in a circuit to control the generation of the gas in the reservoir 22 , thereby controlling a delivery rate of the fluid from the fluid source.
the controller may comprise a fixed or variable resistor and a switch. Control may be exercised by something as simple as a resistor on a switch or something as sophisticated as a microprocessor-controlled circuit operating based on a sophisticated, programmed application.
the controller may include a processor programmatically controlling the value of resistance in the circuit.
the fluid delivery system 10 may also include a sensor (not shown) operably connected to provide inputs to the processor to control the value of resistance in accordance with an algorithm therewith.
At least a portion of the controller is located separately from the galvanic cell and is in communication with the cell by at least one of mechanical hardware, electromagnetic, radio frequency, magnetic, or optical feedback or circuit. In other embodiments, the controller is located inside the reservoir 22 .
the gas generator 20 acts to fill the reservoir 22 in a controlled manner. Accordingly, the reservoir 22 will expand with the volume and pressure of the gas generated by the gas generator 20 . Accordingly, the reservoir 22 , contained on one side by a shell 24 or half 24 of the housing 18 , may expand to displace the fluid source 26 . The fluid source 26 in contact with the reservoir 22 is thus compressed between the reservoir 22 and a wall of the housing 18 , resulting in expression of the fluid. Accordingly, the housing 18 , together with the reservoir 22 and the fluid source 26 may be referred to throughout the specification as a pump 12 .
the fluid source 26 within its shell 28 or half 28 of the housing 18 may actually contain any type of fluid.
gas, liquid, or gel of suitable consistency and chemical composition may dispense from the fluid source 26 .
a fluid may be loaded in the fluid source 26 at a manufacturing plant.
the fluid source 26 may there be sealed to maintain a sterile condition until use.
the fluid source 26 may be filled on site or at point of use by a doctor, pharmacist, or other medical professional responsible.
a fill port 30 may be provided with an access 32 or inlet fixture 32 .
the access 32 may be a septum 32 through which a syringe may penetrate to fill the fluid source 26 .
the fill port 30 may be made of a material of sufficient hardness and length to receive a needle without risk of puncture.
the fill port or may alternatively be a luer lock type.
the fluid source 26 may be formed of any material that will contain the liquid but not actively affect the contained fluid, for example, polyethyleneteraphthalate (PET).
PET polyethyleneteraphthalate
various other polymers such as polyethylene, polypropylene, polyvinylchloride, or the like may be suitable.
the nature of the material of the fluid source 26 should not admit any harmful substances or reactions to the contained fluid.
the shelf life of the fluid must be configured along with the shelf life of the chemical constituents, plasticizers, and other chemicals that may be leached from the wall of the fluid source 26 into the fluid of the fluid.
a medical professional may draw a fluid into a syringe.
the syringe may be fitted to a needle or other injector to penetrate the septum 32 or access 32 to the fill port 30 .
a suitable amount and concentration of a prescribed fluid may fill the fluid source 26 to a suitable level required to service the dressing 16 for a predetermined time.
the volume added to the fluid source 26 may completely fill the fluid source 26 .
the amount of the fluid added to the fluid source 26 may exceed the capacity thereof.
the apparatus 10 may be “jump started” by adding a bolus of fluid to fill the fluid source 26 , the feed conduit 14 , and some portion or all of the dressing 16 .
the dressing 16 may be pre-loaded or even pre-saturated by a fluid when first loaded. Repeated boluses are possible.
the apparatus 10 may be filled by an individual patient.
many superficial wounds such as scrapes and lacerations may benefit from an over-the-counter (OTC) solution, salve, oil, antiseptic, antibiotic or the like.
OTC over-the-counter
an OTC version of the apparatus 10 may be either pre-filled or filled by a user with an OTC fluid.
the apparatus 10 may feed a fluid from the fluid source 26 out through an exit port 34 .
the exit port 34 may be provided with a fitting 36 adapted to accomplish one or several functions.
the fitting 36 may include a check valve to prevent any back flow of the fluid from the feed conduit 14 into the fluid source 26 .
the fitting 36 may include an orifice or other metering device to limit the flow of fluid to a particular rate.
a regulator, check valve, or pressure-relief valve may be part of the fitting 36 to maintain a certain pressure within the fluid source 26 .
the regulator may be outside of, partially within, or completely within the fluid source 26 .
Pressure in the fluid source 26 may be particularly important to precise control of delivery. It may need to increase when operating with particular fluids. Perhaps most frequently, regulation of pressure may resist wide fluctuations in the rate of delivery of the fluid.
barometric pressure, ambient temperature, and the like may directly affect the pressure of gas in the reservoir 22 .
Wide fluctuations in either may be counter-productive to precise metering of a fluid through the fitting 36 .
a pressure-regulation valve is located within the fitting 36 , or otherwise associated therewith, comparatively higher pressure reduces sensitivity of the fluid source 26 or reservoir 22 to ambient pressure and temperature.
a bolus dose is not administered simply as a result of an increase in ambient temperature increasing the volume of the gas in the reservoir 22 .
the fluid source controls a fluid flow to dressing 16 or to a distribution member 40 .
the flow rate may be continuous or discontinuous.
a discontinuous flow rate may be one that turns off and on over a period of time.
a discontinuous flow rate may also be one provided under the variable force of a syringe.
flow rate may be programmatically controlled by a controller. The program may account for fluid flow patterns, either pre-selected or arbitrary, valve, conduit size, and other flow control parameters.
an aperture 38 in either shell 24 of the housing 18 may provide access to a button to control operation of the gas generator 20 .
the aperture 38 may be closed with a cover, seal, diaphragm, or the like.
a rubber cover may fit within the aperture 38 resisting entry of dirt, dust, moisture, and the like into the housing 18 .
a cover of thin, flexible, elastomeric material allows a user to apply pressure to a control button of the gas generator 20 .
a cover member 39 or protective member 39 of a dressing 16 may provide one or more useful functions.
the protective member 39 may be opaque in order to prevent unsightly appearance of the dressing 16 .
the protective member 39 may be transparent in order to provide easy monitoring. One may observe direction the distribution of the fluid throughout the dressing 16 , as well as any seeping of blood or serum back into the dressing 16 from a skin defect being treated.
a protective member 39 may typically resist abrasion, snagging, and other contact or contamination damage to itself and the underlying distribution member 40 .
Other members may exist within a dressing 16 .
a protective member 39 may resist abrasion, transport of fluid, dirt, puncture, or the like.
the protective member 39 may be perforated or porous to permit access of air to a dressing 16 .
the protective member 39 may be liquid proof to prevent escape or wicking of a fluid or other liquid in the dressing 16 into clothing, bedding, or the like.
the protective member 39 may be microperforated or formed of some suitable material that permits passage of oxygen, water vapor or other gases while resisting passage of liquids.
a distribution member 40 holds a fluid delivered from the fluid source 26 through the feed conduit 14 .
the porosity of the distribution member 40 provides distribution of comparatively aqueous like fluids throughout.
the generation of gas from the gas generator 20 into the reservoir 22 applies both pressure and volume variation into the fluid source 26 , driving a flow of fluid at some desired, engineered rate into the dressing 16 .
the fluid source may control the fluid flow to the distribution member 40 .
the feed conduit 14 is connected to the fluid source 26 for replenishing the fluid in the distribution member 40 , with or without additional human intervention.
the housing 18 may be relieved at selected locations to form, for example cradles 42 , 44 capturing the fill port 30 and exit port 34 , respectively.
the cradles 42 , 44 thus permit location of the access (inlet) fitting 32 and outlet fitting 36 outside the housing 18 .
the fitting 36 may be adapted to fit into or around the feed conduit 14 .
the feed conduit 14 may feed into a feed line 48 passing into the dressing 16 .
An inlet port 50 the center of the area of the dressing 16 may distribute the fluid throughout by capillary action the distribution member 40 of the dressing 16 .
a manifold (not shown) may be used. Without a tailored capillary capability in the distribution member 40 , distribution of a fluid throughout the dressing 16 may be enhanced by distributing throughout the distribution member 40 through a manifold.
the manifold may be configured in any suitable manner. It will be appreciated by those of skill in the art that the feed conduit may be part of the dressing 16 itself.
a large plenum having substantial area or a long linear path may present little resistance to flow of the fluid. A larger pressure drop would then occur as the fluid exits through perforations or other flow-limiting orifices.
a manifold may have apertures sized to control or balance out pressure along several paths of distribution through tubes within the manifold. These apertures may provide the major, substantial, pressure drop between the pressure upstream of the manifold, and the ambient pressure in the dressing 16 .
housing 18 may capitalize on manufacturing methods, optimization of costs, ease of manufacturing, simplicity of operation, weight, shape, or the like.
the housing 18 a provides an aspect ratio of thickness to width or thickness to height sufficiently small to fit readily into a pocket.
an active outpatient, wearing of a dressing 16 may remain active.
a comparatively thin, unobtrusive, housing 18 a fits easily into a pocket of any article of clothing.
the housing 18 b may have a lightweight, clam shell configuration.
a lattice 54 sufficient to contain the reservoir 22 and fluid source 26 may not provide puncture proofing for reservoir 22 and fluid source 26 . However, if puncture is not a practical threat to the integrity of an apparatus 10 , the lattice 54 may provide an appropriate wall.
the housing 18 b reservoir 22 and fluid source 26 are not shown, for clarity, but may fit the gas generator 20 and the inlet fitting 32 and outlet fitting as with the housing 18 a.
Each of the housings 18 may be made of suitable size to match the administration of a fluid, ease of use, and carriage needs. For example, a comparatively thinner housing 18 may operate best when the reservoir 22 and fluid source 26 are placed side by side. If the reservoir 22 and fluid source 26 are placed end to end as in the housing 18 c, then the aspect ratio of width to thickness at one end 56 of the housing 18 c may be closer to one. The length of the housing 18 c may be selected to promote complete expansion of the reservoir 22 and fluid source 26 .
the gas generator 20 filling the reservoir 22 may have a button on the outer wall of the housing 18 c, or on one end 56 . Alternatively, access to the gas generator button may be on the same end of the housing 18 c as the inlet fitting 32 and outlet fitting 36 .
the inlet fitting 32 is optional, depending upon whether a fluid is pre-loaded and sealed into a fluid source 26 by a manufacturer. If the fluid source 26 is filled or refilled at the point of use some access fitting 32 is required. However, the housing may be refillable with a pre-filled, sealed reservoir 22 and fluid source 26 in some embodiments.
the housing 18 d may have a rounded, oblong cross section, an oval cross section, or a circular cross section.
One benefit of a right circular cylinder shape is minimizing the overall dimensions of the housing 18 d. Greater volume requires less surface area material if shaped like a sphere. Other shapes are improved as all the aspect ratios of thickness, to width, to length approach unity. Thus, a sphere is capable of holding the maximum volume with the minimum area of wall. Likewise, a right circular cylinder provides a better or greater volume per unit of area of wall then does a rectangular container. Nevertheless, various considerations, including convenience, mobility, and the like may be used to determine what shape, aspect ratios, and materials may be used in each of the housings 18 .
the housing 18 e may be formed of one or more lightweight materials and may even be flexible.
the housing 18 e may actually be formed of a sparse lattice work of a polymer or fiber-reinforced polymer to sustain only internal pressure, not external pressure.
the housing 18 e may be formed as a filament-wound composite material of resin and reinforcing fibers having comparatively (compared to volume changes of liquid with ambient temperature, for example) very rigid walls in tension and compression, even sustaining very high pressures of many atmospheres.
the exit port 34 may include a fitting 36 containing a tiny orifice sized to meter flow of a fluid.
the housing 18 e may sustain pressures of several atmospheres. At higher operating pressures than atmospheric, the effects of barometric or other environmental pressures and temperatures are significantly reduced.
the housing 18 e may have aspect ratios of a pocket pen, or small pocket accessory.
a retainer 58 or clip 58 may secure the housing 18 e to a pocket, clothing, bedding, or other suitable location.
Engineered selection of aspect ratios of diameter to length for any housing 18 may promote unobtrusive location in clothing, bedding, or the like. Reliability of sealing and operation of the reservoir 22 and fluid source 26 has advantages with circular seals.
the housing 18 f has an advantage of providing no substantial corners and a comparatively small aspect ratio of thickness to diameter, suitable for carrying in a purse, pocket, or the like. Meanwhile, manufacturing of the reservoir 22 and fluid source 26 may be simplified, and sealing thereof readily adaptable to various manufacturing processes.
a feed conduit 14 may optimize any parameter affecting cost, deployment, operation, durability, reliability, or the like.
feed conduits 14 may have a round, or comparatively flat aspect.
the feed conduit 14 a may include a very inexpensive bottom layer 62 and top layer 64 sealed together along a flange portion 66 .
the interior 60 of the feed conduit a may be completely empty, forming a tube.
the feed conduit 14 a may be formed of plastic film, plastic-coated paper, foil-coated plastic, or the like. Accordingly, the feed conduit 14 a may be provided in a roll.
the feed conduit 14 a may be cut to length or have fittings on either end preformed to interface with the outlet fitting 36 and the feed line 48 of a dressing 16 .
a fixture adapted to the outlet fitting 36 or feed line 48 may speed handling, connection, and sealing.
the fluid source 26 , feed conduit 14 , and dressing 16 may be formed as an integrated, connected unit for disposable use.
polymer-coated paper may serve the structural and protective functions of all three components.
the feed conduit 14 may be filled with a core 60 or the like.
the cross-sectional area compared to the length of the feed conduit 14 a may be extremely small.
the flanges 66 may more easily sustain internal pressure, if enclosed volume is minimized within the feed conduit 14 a. This corresponds to a filled cross section that is round or square and relatively small.
a core 60 may provide wicking from the outlet fitting 36 to the dressing 16 for several reasons. For example, in certain embodiments, pressure drop through the length of a feed conduit 14 may be desirable. By providing a rather tortuous path in a core 60 , pressure in the fluid source 26 is not the direct driving force for transport. Rather, evaporation in the dressing 16 may draw the fluid by capillary action, replenishing liquids. Thus, the core 60 may provide regulation and replenishment automatically as needed.
Evaporation of liquid from a dressing 16 may provide a means of replenishment of the active suspended or dissolved therein.
one way to assure an adequate concentration of an active ingredient in the fluid in the dressing 16 is to provide a comparatively volatile liquid that will evaporate from a dressing 16 . Accordingly, as the carrier liquid evaporates, the fresh fluid is drawn in, having the concentration available from the fluid source 26 .
the entire dressing 16 , feed conduit 14 , and fluid source 26 may be embodied in a single integrated system 70 .
the volume 68 a may be directly formed or sealed at a factory as a fluid source 26 to be placed in the housing 18 with the feed conduit 14 b protruding there from.
the feed conduit 14 b may then conduct the fluid toward a header 50 or manifold 50 servicing a dressing 16 embodied as the distribution member 68 b.
the distribution member 68 b may be designed or have the same characteristics as the distribution member 40 discussed above.
the entire system can be sealed at a factory, and filled at point of use, or filled at the factory.
a seal may be required to close the reservoir 68 a against leakage into the feed conduit 14 b. If filled at point of use, the entire assembly may be shipped dry.
the disposable fluid source 26 , 68 a may be filled at point of use including optionally priming both the feed conduit 14 b and the distribution member 68 b of the dressing 16 , as desired.
the end 68 b may be an entire dressing assembly 16 , including a distribution member 40 .
the feed conduit 14 b illustrates one embodiment in which the feed conduit 14 may be rolled flat.
the entire assembly 70 may be rolled flat together or rolled together about the distribution member 40 , 68 b or dressing 16 , 68 b.
the feed conduit 14 b may be formed of any suitable material, whether paper, film, foil, other laminates, or the like.
the feed conduit 14 b may be have an integrated distribution member 68 b or dressing 68 b.
the distribution member 68 b may be fed directly by the feed conduit 14 b, or by the feed conduit 14 b through a manifold 50 .
the distribution member 68 b may be the same as a wicking layer 14 of a dressing.
the dressing 16 may be formed flat of plastic film, plastic-backed paper, foil-lined paper, or foiled plastic.
the distribution member 40 , 68 b or perhaps the entire dressing 16 , 68 b, may be formed integrally at manufacture with the feed conduit 14 b.
the dressing 16 , 68 b When the dressing 16 , 68 b is packaged, it may be sealed up and maintained sterile along with its entire feed conduit 14 b.
an integrated dressing 70 is formed to include the fluid source 26 , 68 a, distribution member 40 , 68 b and intervening feed conduit 14 b, deployment may be simplified. Upon deployment, no sealing or connection is needed between the fluid source 26 , 68 a, feed conduit 14 b, and the distribution member 40 , 68 b or dressing 16 , 68 b.
Fittings may be adapted to the feed conduit 14 b to readily connect or may be unnecessary by forming all as a single containment.
the integrated system 70 Upon opening, the integrated system 70 provides a fluid source 26 , 68 a fitting within the housing 18 , a feed conduit 14 b exiting through an appropriate cradle 44 , and a distribution member 40 , 68 b or dressing 16 , 68 b at the opposite end.
a simply activated or rupturable seal may secure the fluid source 26 against any transfer of fluid to the feed conduit 14 b prior to application.
the outlet fitting 36 may be combined with the access fitting 32 .
injection through a septum 32 may provide piercing of a plastic seal to the fluid source 26 in order to permit filling, or simply to permit emptying.
the fluid source 26 may be connected to the feed conduit 14 b as an integrated assembly relying only on the housing 18 and gas fluid source 22 supplied also at point of use.
tubing 14 c may provide a feed conduit. Such tubing may be provided on a reel 69 in bulk, or in a coil suitable for implementation as a plumbing project at point of use.
the fitting 36 may easily be connected to a feed conduit 14 c formed of a polymer or elastomer suitable to form a sealed, snug fit with the fitting 36 .
the feed line 48 may provide sufficient structural stiffness, elasticity, or both to receive a feed conduit 14 c snugly fitted there around.
the feed conduit 14 d may be formed as flat tubing formed of a plastic film, elastomeric material, treated paper, plastic film reinforced by paper, or the like.
the feed conduit 14 d may be provided with tips 72 or fittings 72 to act as seals, and as spreaders to open the feed conduit 14 d.
the fittings 72 support connection of the feed conduit 14 d to the fitting 36 of the pump 12 , as well as to the feed line 48 of the dressing 16 .
a predetermined length of feed conduit 14 d may minimize cost and still maintain reliable sealing between the feed conduit 14 d and its associated fitting 72 a, 72 b.
the fittings 72 may provide a very low cost solution to delivery of fluid from the fitting 36 to the dressing 16 .
a dressing 16 may be configured for generic or specialty purposes.
a dressing 16 a may be formed in a cylindrical configuration.
a bulky shape may be required to fit within a wound that must heal itself closed, rather than be sutured closed.
an interface member 78 may be provided as a non-adhering layer.
a non-adhering layer For example, under the brand name TELFATM a micro-perforated non-adhering polymer film is used in bandages.
a TELFATM layer may be appropriate for the interface member 78 .
the interface member 78 is or contains a non-adhering polymer.
the interface member 78 may be or contain a bioabsorbable polymer.
the interface member 78 includes one or more of the following structures, either alone or in combination: a sheet, foam, a gel, gauze, a porous matrix, a honeycomb, a mop of fibrous material, a comminuted fibrous material, and a tubular structure. It will be appreciated by those of skill in the art that the interface member 78 may be made of other materials known not to adhere to a skin defect.
the interface member 78 is a self-destructive material that can peel away from an adjacent layer or member, such as the distribution member, when the dressing 16 is removed from the skin defect and be left behind on the skin defect.
a gel may control adhesion and self-destruct to prevent adhesion, so long as properly hydrated by the fluid.
the interface may be dissolvable or absorbable over time.
the interface member 78 may also be configured to separate from the skin defect when the dressing is removed.
the distribution member may comprise a “smaller pore size” wicking layer 77 that may distribute a fluid to skin defect through or without an interface member 78 and a “larger pore size” an inner layer 76 that may transport fluid by capillary action also, but with less resistance to flow. Nevertheless, the higher effective distance (larger pore size) across porosity in an inner layer 76 may provide less orientation-independence.
an inner layer 76 may receive a fluid from the feed line 48 a. Accordingly, the inner layer 76 may distribute readily the fluid to the principal wicking layer 77 . The principal wicking layer 77 may assure even distribution thereof.
the dressing 16 b may be configured geometrically to fit any particular application.
wounds that are not of a serious or persistent nature may be closed by suturing.
chronic wounds, and wounds that may be subject to infection may be allowed or required to heal themselves closed, or may be closed only after infection has been eliminated or sufficiently reduced.
a dressing 16 b may be formed to fit within an open wound, thus delivering fluid by contact against the deep, affected, open surfaces of the wound.
the manufacture of the dressing 16 b may begin with a cylinder, such as the layered cylinder of the dressing 16 a.
the cylinder 16 a may then be molded, embedded with holding agents, stitched, heat set, or otherwise shaped as desired. Accordingly, the features of the dressing 16 a may be implemented in a dressing of the configuration of the dressing 16 b illustrated. Many specialty shapes may be made in this way to fit specific needs.
the area of a dressing 16 c may be subdivided into regions. For example, a central region may contain the wound, and a surrounding area may be clear.
two separate feed lines 48 c may be provided to address two separate areas of a dressing. For example, if a wound itself needs an antibiotic, but a surrounding area needs an antiseptic, both may be delivered to different portions of a dressing 16 c or two different dressings 16 c.
a dressing 16 c may receive a fluid through a feed line 48 c into a plenum 82 .
the plenum 82 may act as a manifold 50 feeding various runs 84 or arms 84 distributing a fluid to the farther reaches of the dressing 16 c.
the protective member 39 is shown as transparent in order to view the plenum 82 and runs 84 .
the protective member 39 may be opaque, transparent, thin, thick, or otherwise configured to accomplish its function. Functions may typically be selected from preventing evaporation, promoting evaporation, providing resistance to abrasion, puncture, or other damage, providing access to air, providing protection from air, and so forth.
perforations or other apertures may be selectively distributed.
the entire network 80 may be porous yet resistant to leakage.
each of the plenum 82 and the runs 84 may be full of liquid dispensed only slowly and evenly throughout the dressing 16 c via micropores driven only by pressure from the fluid source 26 .
the plenum 82 and arms 84 may actually be distribution tubes sized to receive and pass a liquid or other fluid readily, yet be sealed along their entire lengths except for an aperture at the end thereof.
a dendritic or branching structure of the arms 84 may take on any suitable shape, whether rectangular, triangular, circular, polygonal, repeated bifurcating, or the like, and may branch sequentially any number of times.
a tree structure may have a trunk or plenum 82 , in which the branches 84 or arms 84 branch from one another, thus providing a network of distribution tubes.
ends of the arms 84 may be drawn down or restricted in some other way in order to equalize pressure throughout, and provide control and distribution at an even rate throughout all of the end points or tips of the arms 84 throughout the dressing 16 c.
the distribution member 40 is then responsible to distribute from the arms 84 throughout itself in order to maintain a distribution of the fluid.
the dressing 16 d may include a protective member 39 , a distribution member 40 , and any other members need for distribution, promotion of flow, protection from outside environmental influences, protection against adhesion with the skin defect, or the like. Meanwhile, after penetration by the feed line 48 d, the distribution system within the dressing 16 d may take on any suitable form, such as those illustrated in FIG. 5 .
the dressing 16 e may actually contain a distribution member with a layer fed by a manifold 50 contiguous and continuous with a core 60 of a feed conduit 14 .
the feed conduit 14 a of FIG. 3 provided an upper layer 64 and base layer 62 sealed to form a feed conduit there between. Either a cavity or passage may be provided or a wicking core 60 .
a dressing 16 f may be formed with a membrane 86 forming either a protective member, or a pocket.
the membrane 86 may be formed as an envelope having distribution openings on the underside thereof against the distribution member 40 of a dressing 16 f.
the feed line 48 may feed into a pocket-like membrane 86 having porosity only around the underside edges thereof. Likewise, the edges themselves may simply be perforated with small perforations tending to render the membrane 86 a large plenum.
the membrane 86 or membrane pocket 86 may be tacked through at certain location across its area, in order to prevent it from inflating in response to the pressure and presence of a fluid therein.
suitable perforations or other porosity may be sized and distributed across its underside, around its periphery, or along the perimeter of its underside in order to deliver a fluid into the underlying dressing 16 f, or into the distribution member 40 of the dressing 16 f.
the dressing 16 g may include a protective member 39 , and an underlying interface member 88 . Between the protective member 39 and the interface member 88 may be a wicking material suitable for the function. Meanwhile, the feed conduit 14 may feed into the dressing 16 g while the dressing itself passes fluid through the microporosity of the interface member 88 .
the protective member 39 of the dressing 16 g may be the wick portion, while the interface member 88 serves as a plenum having a distribution of perforations to feed the fluid into the protective member 39 .
a feed conduit 14 may feed into the interface member 88 formed as a hollow, flat, tube perforated to feed a protective member 39 which may be the wicking layer in this embodiment associated with the dressing 16 g.
a closed, flat, tubular membrane 88 may be perforated on one or both sides to feed into a distribution member 40 .
the tube 88 acts as a plenum 88 , providing the fluid to the perforations crossing into the wicking layer, here represented by a protective member 39 .
Other members may be present in addition for other functionality as discussed hereinabove.
the dressing 16 h formed of a wicking material such as a fiber, fabric, gauze, foam, or other material may be used alone. Alternatively, it may be used to assemble a dressing. In yet another embodiment, it may be located inside other members, such as between a barrier member and a non-stick member shown in FIG. 7 . Accordingly, a full-width manifold 50 may provide an even distribution from an edge of a distribution member 40 .
the distribution member 40 may be engineered to standard or custom shapes, areas, thicknesses, widths, and lengths to meet the flow demands of a fluid to a particular skin defect. Sizes and shapes may include circular, rectangular, or cut-to-order for particular injured areas.
the distribution member 40 is configured to be cut to a desired size and still maintain a substantially uniform volume of fluid across the distribution member 40 . Accordingly, in one embodiment, a cross-section of the distribution member is substantially the same and any other cross-section of the distribution member. It will be appreciated by those of skill in the art that multiple layers or members of the dressing 16 may cut individually or collectively to customize the size of the dressing 16 .
a dressing 16 j may feed a distribution member (not shown) opposite a protective member 39 .
a distribution system 80 or distribution tubes 80 may include a plenum portion 82 as well as various arms 84 .
the plenum 82 or even the entire distribution network 80 may be formed of two layers of film. The side of the film fitted against the distribution member may have microperforations 90 sized to provide an even distribution.
the placement, size, and number of the perforations 90 may control the pressure drop from within the plenum portion 82 into the distribution member 40 .
the pressure differentials between the plenum portion 82 , and the inside of the arms 84 may be comparatively quite small compared to the pressure difference between a fluid source 26 and a plenum 82 .
the distribution pattern of the perforations 90 may provide a limited number of outlets to control distribution into a distribution member 40 .
a dressing 16 k may have spiraling distribution tubes 80 .
the distribution tubes 80 may be perforated along its entire path.
the distribution tubes 80 may be configured as a spiral having a continuously decreasing cross-sectional area.
the size of the internal diameter of the distribution tubes 80 may be constant, but the perforations may be comparatively smaller.
the distribution tubes 80 become a plenum feeding out the fluid into the distribution member 40 .
the distribution tubes 80 may have branches extending from the spiral. On the other hand, manufacturing may dictate a very simple configuration. Accordingly, a constant diameter and regular perforations of suitable size and distributed along its continuous length may operate adequately. Sealing one end of a perforated tubing, with the opposite end serving as a feed line 48 may provide a completely serviceable distribution tubes 80 .
a dressing 16 m may have a serpentine distribution tubes 80 .
the serpentine shape may be formed of commercially available tubing, flat tubing, a pocket between layers of film or other material, or the like.
Pressure drops may be engineered from the pressure of the gas in the reservoir 22 through to the pressure in the fluid source 26 holding the fluid, on to pressure drops through the exit port 34 and fitting 36 as well as the feed conduit 14 . Meanwhile, the pressure dropped from the feed conduit 14 into any manifold 50 or distribution tubes 80 and on to the ambient environment of a dressing 16 may be engineered to make uniform the distribution in the illustrated embodiments.
an engineered distribution member 40 of suitably small pore size is an independence from the effects of orientation.
a dressing is assumed to lie horizontally. Accordingly, in theory, the entire dressing is at an even height.
gravity effects do not alter dramatically the distribution of a fluid there throughout. Accordingly, the force exerted on the fluid by wicking action would be greater than or equal to the force exerted on the fluid by gravity.
an outpatient may actually be active, walking about, engaging in athletic activities, while having a dressing 16 in place on an arm, leg, foot, torso, or the like.
the effect of gravity is to bring a liquid down to the lowest contained altitude possible.
an apparatus and method in accordance with the invention may provide independence of orientation.
a dressing 16 may comprise a feed conduit (as shown and described in connection with FIGS. 1 , 3 , and 5 above) for delivering a fluid to a distribution member.
the dressing 16 m 16 p, 16 q, and 16 r and distribution member receive and distribute the fluid substantially uniformly across the distribution member, irrespective of the orientation of the distribution member.
the term “substantially uniformly” in relation to fluid distributed across the distribution member may mean that fluid is distributed to all parts of the distribution member 16 . This may occur across a particular layer of the distribution member 16 or across all layers of the distribution member 16 . “Substantially uniformly” may also mean that there is not significant pooling of fluid in one area of the distribution member while other areas of the distribution member have less fluid.
“Substantially uniformly” may also mean the volume of fluid in one cross section of the distribution member is similar to the volume of fluid in other similarly sized cross sections of the distribution member. “Substantially uniformly” may also mean that the difference in fluid from section to section across the distribution member is small enough such that the application of the dressing 16 to the skin defect will result in consistent delivery to various areas of the skin defect.
the material of the distribution member 16 may allow for movement or the spread of fluid substantially uniformly across the distribution member by wicking action.
wicking action may include or may be used interchangeably with movement of fluid by capillary action, surface tension, hydrophobic action, hydrophilic action, or similar types of forces that can move a fluid.
Orientation independence may mean that the dressing 16 m may be fed from the top and oriented vertically.
the dressing 16 b is oriented vertically, but fed horizontally, while, the dressing 16 q is oriented horizontally and fed horizontally.
the dressing 16 r is oriented vertically, and fed from below. In all of illustrated embodiments in FIG. 6 , the orientation of the dressing 16 may be ineffectual to inhibit distribution.
the distribution member comprises at least one material chosen from a polymer, a woven fabric, a non-woven fabric, a naturally occurring fiber, a sponge, a fiber matrix, a gauze, absorbent material, adsorbent material, a gel, and a foam.
the distribution member 16 is a porous pouch.
a distribution member 40 may be bonded to a protective member 39 at regular intervals along a line, across a grid, or the like. Accordingly, two members not allowed to separate more than a nominal distance resist fluid accumulation.
a dressing 16 may constructed of the distribution member 40 to effectively defy gravity and distribute the medicament, even upward from a location where introduced. Accordingly, the distribution member 40 may receive and distribute the fluid substantially uniformly across the distribution member, irrespective of the orientation of the distribution member.
the distribution member 40 maintains a predetermined amount of fluid substantially uniformly across the distribution member.
the distribution member 40 may in some configurations release fluid at a saturation point of level of the distribution member 40 . In other embodiments, the release of fluid by the distribution member 40 may occur before or after that time. It will be appreciated by those of skill in the art that the rate and amount of fluid into the distribution member 40 , coupled with the pore size of the distribution member 40 and the structure of adjacent members may be used to determine at what point the distribution member 40 may release fluid and also to what extent the fluid is distributed throughout the distribution member 40 . It will further be appreciated by those of skill in the art that by having a distribution member configured to uniformly distribute fluid, or in other words, to have similar amounts of fluid occupy the different areas of the distribution member 40 , that better application of the fluid to the skin defect can be obtained.
the distribution member 40 was tested in one test by applying the dressing vertically to a sheet of glass. An amount of colored fluid was applied to the center of the distribution member and the spread of fluid was recorded over time. Viewing the recording after various points in time revealed that fluid was radially distributed from the point of introduction uniformly in all section of the distribution member despite the down ward pull of gravity. Thus, at different points in time, the outer boundary of the spreading fluid created substantially concentric circles under the entire distribution member was filled with fluid. Dozens of tests were performed with substantially similar results.
the configuration of the distribution member 40 of the present embodiment may also allow the distribution member to maintain a concentration of active ingredient in the fluid substantially uniformly across the distribution member and allow said concentration of active ingredient in the fluid to communicate with the skin defect.
the distribution member 40 may be engineered to allow the concentration of the fluid to be uniformly distributed across the distribution member.
the distribution member 40 may allow fluid distribution such that a concentration of the fluid in one area of the distribution member is substantially similar to the concentration of the fluid in another area of the distribution member.
the distribution member may maintain a concentration of active ingredient in the fluid substantially uniformly within a predetermined range of concentration across the distribution member and may allow said concentration in said range to communicate with the skin defect.
the dressing 16 comprises a feed conduit for delivering a fluid to a distribution member 40 .
the distribution member 40 receives and distributes the fluid substantially uniformly across the distribution member 40 , irrespective of the orientation of the distribution member 40 .
the distribution member 40 comprises material that allows the spread of fluid substantially uniformly across the distribution member 40 by wicking action and can be cut to a desired size and still maintain a substantially uniform volume of fluid across the distribution member 40 .
a dressing 16 may include one or many members to accomplish their respective functions.
a member 92 may be a protective member 92 .
Protective members 92 are typically installed to prevent puncture, abrasion, snagging, evaporation, wetting, soiling, and the like.
a protective member 92 may operate to provide multiple functions. It will be appreciated by those of skill in the art that the protective member 92 may be the protective member 39 discussed above.
a durable fabric may be used as an protective member 92 to promote evaporation and aeration while still protecting against puncture, snagging, abrasion, wear, and the like.
other members such as polymeric materials may minimize access to air, optimize evaporation of fluids, or the like.
the protective member 92 may be designed according to the functionality desired.
the member 93 may be a stay-dry (hydrophobic) lining.
the wicking layer 94 may need to be separated by a stay-dry liner 93 . Accordingly, the lining member 93 rejects transport of liquids therethrough, therein, or both. Liquids preferentially stay in the wicking layer 94 .
the members 92 and 93 may be reversed.
a stay-dry material may form the protective member 92 .
the structurally protective member 92 typically serves best as the outermost member. Accordingly, the protective member 92 , may itself need to be protected against wicking from liquids being transported in a wicking transport member 94 .
a stay-dry lining member 93 rejects the transport of liquid from the wicking layer 94 into either of the protective member 92 and the outside environment.
a stay-dry lining member 93 resists wicking into the protective member 92 .
a stay-dry lining 93 may resist the transport of liquid out of the transport wicking layer 94 . If the protective member 92 is imperious to liquid, then a stay-dry linen member 93 may not be required.
the protective member 92 may be primarily a mechanical protection, very porous and susceptible to absorbing liquid from an optional transport wicking layer 94 .
the wicking layer 95 is typically formed of a material having a smaller effective pore size than that of the protective member 92 or the transport wicking layer 94 . Accordingly, the wicking material 95 preferentially attracts fluids from the transport wicking layer 94 . Thus the wicking layer 95 may be the principle delivery member for the skin defect.
the stay-dry member 93 may be integral with or one and the same as the protective member 92 and the protective member 92 may have all the characteristics and functionality of the stay-dry member 93 .
wicking layers 94 , 95 is optional. Either may suffice. However a smaller pore size promotes delivery independent from orientation, while larger pore size promotes faster capillary transport.
a member 94 may thus be thought of as a distribution member.
the distribution member 94 may provide a pore size (e.g. interstitial gap, etc.) having less resistance to flow then the wicking layer 95 . It will be appreciated by those of skill in the art that the distribution member 94 may also be the distribution member 40 and/or 68 b described above.
a non-adhering interface member 96 may cover the principal wicking layer 95 which may be part of the distribution member.
the interface member 96 may be the same interface member 78 described above.
Dimensions of the dressing 16 of FIG. 7 may be selected as appropriate. For example, the scales or sizes of the thickness of the non-adhering interface member 96 and the wicking distribution member 95 are effectively polar opposites.
the non-adhering interface member 96 (if a solid polymer) is typically as thin as possible and perforated in order to promote transport of the fluid from the wicking layer 95 .
the non-adhering interface member 96 is a gel, it may diffuse an active ingredient with or without the carrier to the treated skin defect.
a gel may also largely liquefy or disintegrate (to a greater or lesser extent, depending on formulation) in the presence of liquids, promoting direct delivery of a liquid from a wicking layer 95 to skin defect.
the interface member 96 is positioned between the distribution member 94 and a skin defect being treated by the dressing 16 .
the interface member 96 configured to transport the fluid into contact with the skin defect.
the protective member 92 may be positioned adjacent to the distribution member 94 .
the protective member 92 may protect the distribution member 94 from loss of functionality. For example, if the distribution member 94 is damaged in some way or clogged or if the structure is altered, the distribution member 94 may not spread the fluid substantially uniformly.
the protective member 92 may be semi-occlusive and may aid in directing fluid out of the distribution member 94 and onto the skin defect.
the protective member 92 might ensure ability of moisture or vapors to leave the distribution member and to leave the dressing in order to balance the moisture content of the dressing and thus the fluid level balance in the skin defect.
the dressing 16 of FIG. 7 may be configured with any of the members 92 - 96 shown, some of them, or additional members, as desired. Typically, any of the dressings 16 discussed hereinabove may be made with one or more of the members 92 - 96 illustrated in the dressing 16 . Accordingly, a multi member dressing 16 may be engineered to accomplish its functions in the most effective way by using the appropriate selection of members 92 - 96 .
the multi-member dressing may include a wicking layer receiving the fluid, a barrier member that may or may not be configured to protect the dressing from the environment and provide for vapor transmission, a transfer member to transfer the fluid to the distribution member, an fluid absorber member to absorb excessive fluid being delivered or for absorbing the wound exudate, a tenting member positioned at the rim of the dressing to provide for lateral evaporation, and an interface member between the wicking layer and the treated skin defect to transfer the fluid thereto from the wicking layer while performing any other function needed, such as sealing, anti-adhesion, or the like.
the dressing may comprise at least one functional member consisting of a distribution member an interface member, a transport member, a protective member, and an absorption member.
one or more of the members 92 - 96 may be structured to operate as at least one of an interface member, a distribution member, a fluid transport member, a protective member, a tenting member, a fluid absorber, and a combination thereof.
a controller 100 may control an electrochemical reactor 98 producing byproducts 101 or gasses 101 . These byproducts 101 a, 101 b are generated in response to the spontaneous flow of electrons and ions in the electrochemical reactor 98 or galvanic cell 98 .
the active members 102 , 106 may contribute or consume electrons. Either one may generate a byproduct 101 that becomes a gas for the reservoir 22 ( FIGS. 1 and 2 ).
one material 102 , 106 may create a byproduct 101 as a gas, while the other material 106 , 102 produces a byproduct that stays in solution or plates out at a surface of the other active material 106 , 102 .
a separator 104 may or may not be used in-between the two active materials.
the electrochemical reactor 98 may be made to generate a byproduct 101 in a gaseous state by choosing the chemistry of the electrodes 102 , 106 and controlling the electrical current through a circuit 107 .
the electricity generated or the current generated through the circuit 107 is not the object, but rather the byproduct gasses that are discharged as a result of the flow of electrons.
a battery or galvanic cell 98 is designed to optimize the generation of the byproduct 101 , rather than optimizing the output of electricity through the circuit 107 .
the circuit 107 may control electron flow, and thus the generation of gas.
a controller 100 a may include a switch 110 to close the circuit 107 .
some impedance 108 such as a resistor 108 , may be in the circuit 107 .
a controller 100 in a simplest embodiment may simply be a module 100 a or controller 100 a providing a physical switch 110 and an impedance 108 .
the switch 110 may selectively open and close.
the switch may operate a single time to move from an open position to a closed position.
the switch 110 may selectively open again to stop generation of gas.
a controller 100 b may include a control panel 112 having a display 114 .
a user may read instructions or bring up menus on the display 114 .
buttons 115 - 118 a user may select an “on” or “off” condition, provide a rate increase or decrease in the production of gas.
a controller 100 b may be a simple analog or digital circuit accomplishing certain limited functions. Likewise, the controller 100 b may include additional sophistication.
a controller 100 c may actually be a microprocessor-based controller 100 c.
a central processing unit 120 (CPU 120 ) may operably connect to a memory device 122 .
the processor 120 may operate controls 124 such as relays, gates, and the like for increasing current flow from a very low rate through the circuit 107 to a very high rate.
the processor 120 may receive instructions, data, or the like, through an input/output interface 126 (I/O interface).
I/O interface input/output interface
sensors 128 may operably connect to provide inputs to the I/O interface 126 .
Sensors 128 may monitor pressures, humidity, chemical concentration, electrochemical properties, or the like from the dressing 16 or elsewhere in the system 10 and report through the I/O interface 126 to the processor 120 to control the device operation.
the processor 120 may be programmed with an application 130 stored in a memory device 122 .
the processor 120 may execute the application 130 to provide feedback control based on sensors 128 to control a value of a desired property, parameter, or condition associated with the dressing 16 .
the pump 12 may be controlled according to humidity sensed by a sensor 128 within the dressing 16 .
a portion of the dressing 16 may be sensed to determine that the liquid of a fluid has evaporated or has a certain concentration of a chemical detected.
the pump may be as simple or sophisticated as warranted by cost, medical constraints, or desired controls for applying a fluid to a dressing 16 .
any physical parameter that may be sensed by a sensor 128 may be used to control the processor 120 through a suitable application 130 programmed to do so. Accordingly, more gas may be generated by the generator 20 , prompting the flow of additional fluid from the fluid source 26 through the feed conduit 14 and into the dressing 16 .
the application 130 will operate on top of an operating system 132 or O/S 132 .
Other functional features may be accomplished by other software 134 executed in the processor 120 based on data 134 in memory 122 .
other data 134 may include a history of operation of the gas generator 20 by time, chemical, current, gas volume, or the like. So long as physical equations are known, they can be programmed into the application 130 to detect and store data 134 .
Data 134 may also include other applications such as supporting applications, control applications, data management applications, and the like.
a cross section of a housing 18 may include a reservoir 22 storing gas.
a fluid source 26 may contact a reservoir 22 . Motion or pressure by the reservoir 22 will result in corresponding motion or pressure in the fluid source 26 .
the fluid source 26 may be pre-filled or filled at point of use.
the reservoir 22 and fluid source 26 may be installed such that initially the gas reservoir 22 occupies very little or comparatively little space. Meanwhile, upon filling, either at a factory or at point of use, the fluid source 26 typically occupies the majority of the space within the housing 18 .
the reservoir 22 and fluid source 26 may substantially occupy the available space within the housing 18 .
the reservoir 22 and fluid source 26 may have elastomeric properties. However, elastomeric materials may also react with certain fluids.
fluids involve extremely small amounts of an active ingredient in an overwhelming volume of a carrier.
an active ingredient may be very reactive.
a trace amount of a metal or other contaminant may react with a large amount of an available active ingredient.
the fluid source 26 is better served if made of less reactive materials.
the fluid source 26 should typically not have any deleterious effect on the fluid. Likewise, no constituent of the fluid's active ingredient, carrier, or other excipient should attack the integrity of the fluid source 26 during its operational lifetime. Accordingly, materials, sizes, and properties may be selected to provide an optimum chemical stability, mechanical integrity, pressure support, and so forth needed for the particular apparatus 10 and method contemplated.
the reservoir 22 and fluid source 26 may actually have elastic properties (e.g. elastic restrictions, spring pistons, etc.) and provide some resisting amount of pressure when inflated.
the reservoir 22 and fluid source 26 may have a substantially fixed wall area, capable of enclosing a fixed maximum volume. Accordingly, as either the reservoir 22 or the fluid source 26 is filled, it may expand toward its maximum volume without substantial resistance until that point is reached.
a reservoir 22 and fluid source 26 may be formed of laminated or bonded layers of materials.
the housing may be openable or sealed, disposable or re-usable.
the reservoir 22 and fluid source 26 need not be limited to a single reservoir each within the housing 18 . Multiple reservoirs 22 may be used or multiple fluid sources 26 . Likewise, reservoir 22 and fluid source 26 may be replaceable, refillable, or both.
a very simple switch 100 may control a gas generator 20 filling a reservoir 22 .
the time may be fixed by the chemistry, size, and so forth of the principle elements 102 , 104 , 106 of the electrochemical reactor 98 .
a second reservoir 22 , with a second gas generator 20 may be useful for operating the apparatus 10 a second time, after refilling of the fluid source 26 .
a multi-use, disposable unit may still result with very primitive controls 100 .
a method for treating a skin defect includes providing a dressing or fluid delivery system comprising a feed conduit and a distribution member in fluid communication with the feed conduit.
the distribution member is configured to receive a fluid and comprising a material to substantially uniformly distribute the fluid across the distribution member irrespective of the orientation of the distribution member.
the method includes applying the dressing to a skin defect and supplying a fluid to the distribution member through the feed conduit.
Supplying a fluid in one embodiment may include supplying a pre-determined quantity of fluid containing an active ingredient.
Supplying a fluid may also include priming the dressing with a quantity of fluid.
priming the dressing with a quantity of fluid is a separate step.
Supplying a fluid may also include providing a bolus of fluid to the dressing before or after an initial quantity of fluid is supplied.
supplying a quantity of fluid is provided manually from a fluid source to the dressing.
fluid is automatically provided from a fluid source to the dressing.
the dressing or system may include a controller of the type described herein which may be programmed to supply the fluid at a predetermined flow rate or time interval. The supply of fluid by any of these methods may be continuous or at intervals with varying flow rates.
the method includes the step of distributing the fluid substantially uniformly across the distribution member.
the method also includes substantially uniformly distributing the fluid to the skin defect irrespective of the orientation the distribution member.
Supplying fluid to the distribution member comprises maintaining a fluid with a concentration of active ingredient greater than, equal to, or less than a predetermined threshold over a predetermined period of time. This may include maintaining the concentration of the fluid at a minimally therapeutically effective threshold throughout the distribution member. Supplying a quantity of fluid to the distribution member may be such that the skin defect receives a concentration of the active ingredient greater than a therapeutically effective threshold corresponding to a minimum inhibitory concentration.
a concentration of active ingredient may be selected to substantially minimize the development of resistance, by a target organism, to the active ingredient, throughout a pre-selected period of time. Maintaining a concentration of active ingredient in the distribution member above, at, or below a threshold, such that the desired concentration is applied to the skin defect may be beneficial to facilitate pain or inflammation reduction or to promote healing of the tissue.
the method may also include trimming or cutting the dressing or one or more layers or member that make up the dressing to a desired shape corresponding to a treatment area.

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Animal Behavior & Ethology (AREA)
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Hematology (AREA)
Anesthesiology (AREA)
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US12/341,832 2008-02-27 2008-12-22 Auto-replenishing, wound-dressing apparatus and method Abandoned US20090216204A1 (en)

Priority Applications (3)

Application Number	Priority Date	Filing Date	Title
US12/341,832 US20090216204A1 (en)	2008-02-27	2008-12-22	Auto-replenishing, wound-dressing apparatus and method
US14/305,995 US10279156B2 (en)	2008-02-27	2014-06-16	Auto-replenishing, wound-dressing apparatus and method
US16/245,867 US11497652B2 (en)	2008-02-27	2019-01-11	Auto-replenishing, wound-dressing apparatus and method

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US1595208P	2008-02-27	2008-02-27
US12/341,832 US20090216204A1 (en)	2008-02-27	2008-12-22	Auto-replenishing, wound-dressing apparatus and method

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US14/305,995 Division US10279156B2 (en)	2008-02-27	2014-06-16	Auto-replenishing, wound-dressing apparatus and method

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US20090216204A1 true US20090216204A1 (en)	2009-08-27

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US12/341,832 Abandoned US20090216204A1 (en)	2008-02-27	2008-12-22	Auto-replenishing, wound-dressing apparatus and method
US14/305,995 Active 2032-03-12 US10279156B2 (en)	2008-02-27	2014-06-16	Auto-replenishing, wound-dressing apparatus and method
US16/245,867 Active 2031-01-29 US11497652B2 (en)	2008-02-27	2019-01-11	Auto-replenishing, wound-dressing apparatus and method

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US14/305,995 Active 2032-03-12 US10279156B2 (en)	2008-02-27	2014-06-16	Auto-replenishing, wound-dressing apparatus and method
US16/245,867 Active 2031-01-29 US11497652B2 (en)	2008-02-27	2019-01-11	Auto-replenishing, wound-dressing apparatus and method

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US (3)	US20090216204A1 (fr)
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Cited By (45)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20090264838A1 (en) *	2008-04-21	2009-10-22	Enzysurge Ltd.	Liquid streaming devices for treating wounds, method of making such devices, and method of using such devices for treating wounds
US20110276016A1 (en) *	2009-01-15	2011-11-10	Mingliang Lawrence Tsai	Aspirated wound dressing
WO2013138325A1 (fr) *	2012-03-12	2013-09-19	Ivwatch, Llc	Pansement pour un site d'insertion d'un perfusat intravasculaire
US8715256B2 (en)	2007-11-21	2014-05-06	Smith & Nephew Plc	Vacuum assisted wound dressing
WO2014031491A3 (fr) *	2012-08-23	2014-05-30	Nioxx Llc	Production prolongée d'oxyde nitrique à partir de réactifs chimiques microencapsulés
US8764732B2 (en)	2007-11-21	2014-07-01	Smith & Nephew Plc	Wound dressing
US8808274B2 (en)	2007-11-21	2014-08-19	Smith & Nephew Plc	Wound dressing
US20140330227A1 (en)	2010-03-16	2014-11-06	Kci Licensing, Inc.	Delivery-and-fluid-storage bridges for use with reduced-pressure systems
WO2014126888A3 (fr) *	2013-02-12	2015-02-26	Electrochemical Oxygen Concepts, Inc.	Pansement pour traitement des plaies
US20150119831A1 (en)	2013-10-30	2015-04-30	Kci Licensing, Inc.	Condensate absorbing and dissipating system
US20150245950A1 (en) *	2014-03-03	2015-09-03	Kci Licensing, Inc.	Low profile flexible pressure transmission conduit
US20160136364A1 (en) *	2014-11-13	2016-05-19	Barry university	Nitric oxide delivery system and methods of use
EP3030206A4 (fr) *	2013-08-07	2017-03-15	Plurogen Therapeutics, LLC	Administration de médicaments par pansement à pression négative continue
US20170100565A1 (en) *	2013-03-15	2017-04-13	Boston Scientific Scimed, Inc.	Methods and systems for treatment of a bladder
US20170258547A1 (en) *	2016-03-13	2017-09-14	Svetlana Karasina	Surgical item counting station and method of use
US9861532B2 (en)	2011-12-16	2018-01-09	Kci Licensing, Inc.	Releasable medical drapes
US9925092B2 (en)	2013-10-30	2018-03-27	Kci Licensing, Inc.	Absorbent conduit and system
US9956120B2 (en)	2013-10-30	2018-05-01	Kci Licensing, Inc.	Dressing with sealing and retention interface
US10010656B2 (en)	2008-03-05	2018-07-03	Kci Licensing, Inc.	Dressing and method for applying reduced pressure to and collecting and storing fluid from a tissue site
US10016544B2 (en)	2013-10-30	2018-07-10	Kci Licensing, Inc.	Dressing with differentially sized perforations
US10271995B2 (en)	2012-12-18	2019-04-30	Kci Usa, Inc.	Wound dressing with adhesive margin
US10299966B2 (en)	2007-12-24	2019-05-28	Kci Usa, Inc.	Reinforced adhesive backing sheet
US10350114B2 (en) *	2008-10-29	2019-07-16	Kci Licensing, Inc.	Open-cavity, reduced-pressure treatment devices and systems
US10357406B2 (en)	2011-04-15	2019-07-23	Kci Usa, Inc.	Patterned silicone coating
US10398604B2 (en)	2014-12-17	2019-09-03	Kci Licensing, Inc.	Dressing with offloading capability
US10406266B2 (en)	2014-05-02	2019-09-10	Kci Licensing, Inc.	Fluid storage devices, systems, and methods
US10456416B2 (en)	2015-01-20	2019-10-29	Plurogen Therapeutics, Llc	Compositions and methods of treating microbes
US10561534B2 (en)	2014-06-05	2020-02-18	Kci Licensing, Inc.	Dressing with fluid acquisition and distribution characteristics
US10568767B2 (en)	2011-01-31	2020-02-25	Kci Usa, Inc.	Silicone wound dressing laminate and method for making the same
US10632020B2 (en)	2014-02-28	2020-04-28	Kci Licensing, Inc.	Hybrid drape having a gel-coated perforated mesh
CN111938913A (zh) *	2020-08-10	2020-11-17	吉林大学	一种内分泌失调术后伤口防感染护理设备
US10842707B2 (en)	2012-11-16	2020-11-24	Kci Licensing, Inc.	Medical drape with pattern adhesive layers and method of manufacturing same
US10940047B2 (en)	2011-12-16	2021-03-09	Kci Licensing, Inc.	Sealing systems and methods employing a hybrid switchable drape
US10946124B2 (en)	2013-10-28	2021-03-16	Kci Licensing, Inc.	Hybrid sealing tape
US10973694B2 (en)	2015-09-17	2021-04-13	Kci Licensing, Inc.	Hybrid silicone and acrylic adhesive cover for use with wound treatment
US11096830B2 (en)	2015-09-01	2021-08-24	Kci Licensing, Inc.	Dressing with increased apposition force
US20210267540A1 (en) *	2018-07-17	2021-09-02	Vitestro Holding B.V.	Cannula insertion system
US11246975B2 (en)	2015-05-08	2022-02-15	Kci Licensing, Inc.	Low acuity dressing with integral pump
EP3773782A4 (fr) *	2018-05-16	2022-03-02	Midwest Training and Development Services, LLC	Système de pose de pansement sur une plaie à pression négative
US11633551B2 (en)	2014-11-13	2023-04-25	Hansen Pharmaceutical, Llc	Gaseous nitric oxide delivery system and methods of use
US20230381401A1 (en) *	2020-08-13	2023-11-30	Kci Manufacturing Unlimited Company	Negative-pressure therapy dressing with viewing window
US20240050361A1 (en) *	2022-08-10	2024-02-15	Annadurai Dharmarajan	Topical product hands-free applicator drug delivery system and methods of making and using the same
WO2025008231A1 (fr) *	2023-07-04	2025-01-09	Simatec Ag	Système de distribution d'un fluide de principe actif, en particulier d'un principe actif efficace sur une plante et/ou un insecte
US12458320B2 (en)	2019-01-07	2025-11-04	Vitestro Holding B.V.	Contact sensor positioning system, cannula insertion system and method to position a contact sensor
US12491121B2 (en)	2007-11-21	2025-12-09	Smith & Nephew Plc	Wound dressing

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US10058642B2 (en)	2004-04-05	2018-08-28	Bluesky Medical Group Incorporated	Reduced pressure treatment system
US8062272B2 (en)	2004-05-21	2011-11-22	Bluesky Medical Group Incorporated	Flexible reduced pressure treatment appliance
US7909805B2 (en)	2004-04-05	2011-03-22	Bluesky Medical Group Incorporated	Flexible reduced pressure treatment appliance
US8287506B2 (en) *	2007-10-26	2012-10-16	Electrochemical Oxygen Concepts, Inc.	Apparatus and methods for controlling tissue oxygenation for wound healing and promoting tissue viability
US9033942B2 (en)	2008-03-07	2015-05-19	Smith & Nephew, Inc.	Wound dressing port and associated wound dressing
US8298200B2 (en)	2009-06-01	2012-10-30	Tyco Healthcare Group Lp	System for providing continual drainage in negative pressure wound therapy
US20100324516A1 (en)	2009-06-18	2010-12-23	Tyco Healthcare Group Lp	Apparatus for Vacuum Bridging and/or Exudate Collection
ES2731200T3 (es)	2009-12-22	2019-11-14	Smith & Nephew Inc	Aparatos para terapia de herida por presión negativa
US9061095B2 (en)	2010-04-27	2015-06-23	Smith & Nephew Plc	Wound dressing and method of use
USRE48117E1 (en)	2010-05-07	2020-07-28	Smith & Nephew, Inc.	Apparatuses and methods for negative pressure wound therapy
USD714433S1 (en)	2010-12-22	2014-09-30	Smith & Nephew, Inc.	Suction adapter
CN103384538B (zh)	2010-12-22	2017-03-22	史密夫和内修有限公司	用于负压伤口治疗的设备和方法
DE102014001898B4 (de) *	2014-02-14	2021-09-09	Fresenius Medical Care Deutschland Gmbh	Abdeckungseinrichtung und Vorrichtung zur Überwachung der Konnektoren eines Schlauchsystems
EP3093031A1 (fr) *	2015-05-11	2016-11-16	3M Innovative Properties Company	Système de traitement des plaies
TWI629072B (zh) *	2017-01-13	2018-07-11	廈門聖慈醫療器材有限公司	吸盤
GB201811449D0 (en)	2018-07-12	2018-08-29	Smith & Nephew	Apparatuses and methods for negative pressure wound therapy
GB201817052D0 (en)	2018-10-19	2018-12-05	Smith & Nephew	Tissue treatment device
GB202000574D0 (en)	2020-01-15	2020-02-26	Smith & Nephew	Fluidic connectors for negative pressure wound therapy
GB2635861B (en) *	2020-04-02	2025-09-03	Smith & Nephew	Wound dressing
GB202005867D0 (en) *	2020-04-22	2020-06-03	Smith & Nephew	Tissue treatment device
USD1095846S1 (en)	2022-08-17	2025-09-30	Fisher & Paykel Healthcare Limited	Tissue care device
USD1094725S1 (en)	2023-07-11	2025-09-23	Fisher & Paykel Healthcare Limited	Tissue care device

Citations (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3951147A (en) *	1975-04-07	1976-04-20	Metal Bellows Company	Implantable infusate pump
US4382441A (en) *	1978-12-06	1983-05-10	Svedman Paul	Device for treating tissues, for example skin
US5785688A (en) *	1996-05-07	1998-07-28	Ceramatec, Inc.	Fluid delivery apparatus and method
US20020128578A1 (en) *	1997-08-01	2002-09-12	3M Innovative Properties Company	Medical article having fluid control film
US6458109B1 (en) *	1998-08-07	2002-10-01	Hill-Rom Services, Inc.	Wound treatment apparatus
US20020150720A1 (en) *	2001-04-16	2002-10-17	Howard Pamela A.	Wound dressing system
US20030108587A1 (en) *	2001-05-15	2003-06-12	Orgill Dennis P.	Methods and apparatus for application of micro-mechanical forces to tissues
US20030204329A1 (en) *	2002-04-24	2003-10-30	Marchitto Kovin S.	Feedback control device for transcutaneous drug delivery and uses therefor
US20050177118A1 (en) *	1994-05-13	2005-08-11	Hoganson David M.	Resorbable polymeric device for localized drug delivery

Family Cites Families (71)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ZA762197B (en)	1975-04-15	1977-04-27	Int Paper Co	Fluid evacuator
US4090514A (en)	1976-10-22	1978-05-23	Howard Helmut Hinck	Pressure infusion device
US4194041A (en)	1978-06-29	1980-03-18	W. L. Gore & Associates, Inc.	Waterproof laminate
US4657160A (en)	1984-09-13	1987-04-14	Andy Woods	Pressure infusion control
US4735613A (en)	1986-10-23	1988-04-05	Biomedical Dynamics Corporation	Pressure infusion device
DE3882202D1 (en)	1987-05-18	1993-08-12	Disetronic Ag	Infusionsgeraet.
US5176663A (en) †	1987-12-02	1993-01-05	Pal Svedman	Dressing having pad with compressibility limiting elements
US4969880A (en)	1989-04-03	1990-11-13	Zamierowski David S	Wound dressing and treatment method
SE462516B (sv) †	1989-07-11	1990-07-09	Paal Svedman	Spolfoerband foer djupa saar
US5358494A (en) †	1989-07-11	1994-10-25	Svedman Paul	Irrigation dressing
US5053012A (en)	1989-09-29	1991-10-01	Harmac Medical Products, Inc.	Disposable pressure cuff having flow-through pressure gauge
US5152757A (en)	1989-12-14	1992-10-06	Brigham And Women's Hospital	System for diagnosis and treatment of wounds
US5492534A (en) *	1990-04-02	1996-02-20	Pharmetrix Corporation	Controlled release portable pump
US5318540A (en)	1990-04-02	1994-06-07	Pharmetrix Corporation	Controlled release infusion device
DE4012232A1 (de)	1990-04-14	1991-10-17	Franz Josef Gross	Redon- bzw. instillationsverband, insbesondere zur behandlung tieferer und fibrinoes eitriger wunden
US5090963A (en)	1990-10-19	1992-02-25	Product Development (Z.G.S.) Ltd.	Electrochemically driven metering medicament dispenser
US5147310A (en)	1990-11-13	1992-09-15	Giannini Peter T	Pressure infusion system
IL97099A0 (en)	1991-01-30	1992-03-29	Scient Innovations Ltd	Infusion pump with safety means controlling the electrolytic cell
WO1993010391A1 (fr)	1991-11-22	1993-05-27	Denis Arthur John Patterson	Distributeur
EP0598867B1 (fr)	1992-06-15	1997-03-05	WYSSMANN, Max	Dispositif permettant de distribuer un liquide ou une matiere visqueuse de maniere ciblee et controlee
US5318557A (en)	1992-07-13	1994-06-07	Elan Medical Technologies Limited	Medication administering device
GB2272645B8 (en) †	1992-11-23	2010-02-10	Johnson & Johnson Medical	Wound dressing
US5427870A (en)	1994-09-06	1995-06-27	Ceramatec, Inc.	Gas releasing electrochemical cell for fluid dispensing applications
JPH07227424A (ja)	1994-02-17	1995-08-29	Japan Storage Battery Co Ltd	流体輸送器
CA2129210A1 (fr) †	1994-03-31	1995-10-01	Debra Jean Mcdowall	Couche de diffusion de liquides pour articles absorbants
JPH0824619A (ja)	1994-07-14	1996-01-30	Japan Storage Battery Co Ltd	流体供給装置及びその製造方法
JPH0858897A (ja)	1994-08-12	1996-03-05	Japan Storage Battery Co Ltd	流体供給装置
US6060196A (en)	1995-10-06	2000-05-09	Ceramtec, Inc.	Storage-stable zinc anode based electrochemical cell
US5707499A (en)	1995-10-06	1998-01-13	Ceramatec, Inc.	Storage-stable, fluid dispensing device using a hydrogen gas generator
WO1998011937A1 (fr) †	1996-09-17	1998-03-26	Deka Products Limited Partnership	Systeme d'administration de medicaments par transport
US5899381A (en)	1997-02-21	1999-05-04	Ceramatec, Inc.	Electrochemical device for delivery of volatile substances
US6045055A (en)	1997-03-03	2000-04-04	Ceramatec, Inc.	Device and method for delivering fluid
WO1998038953A1 (fr)	1997-03-03	1998-09-11	Medical Solutions, Inc.	Procede et appareil de perfusion sous pression et de regulation de la temperature de liquides perfuses
US6530900B1 (en)	1997-05-06	2003-03-11	Elan Pharma International Limited	Drug delivery device
US7759538B2 (en) †	1997-05-27	2010-07-20	Wilhelm Fleischmann	Process and device for application of active substances to a wound surface
DE19722075C1 (de)	1997-05-27	1998-10-01	Wilhelm Dr Med Fleischmann	Vorrichtung zur Applikation von Wirkstoffen an einer Wundoberfläche
US6787008B2 (en)	2001-10-30	2004-09-07	Microlin, L.C.	Hydrogen generating cell with cathode
US7614568B2 (en)	2000-08-24	2009-11-10	Microlin, Llc	Device employing gas generating cell for facilitating controlled release of fluid into ambient environment
US6071267A (en) †	1998-02-06	2000-06-06	Kinetic Concepts, Inc.	Medical patient fluid management interface system and method
US6767334B1 (en)	1998-12-23	2004-07-27	Kci Licensing, Inc.	Method and apparatus for wound treatment
US6220267B1 (en)	1999-01-27	2001-04-24	Ceramatec, Inc.	Apparatus and method for controllably delivering fluid to a second fluid stream
US6169223B1 (en)	1999-02-08	2001-01-02	Internationale Verbandstoff Fabrik Schaffhausen	Compress for medical treatment
EP1183059A1 (fr)	1999-06-08	2002-03-06	Medical Research Group, Inc.	Procede et appareil de perfusion de liquides par reaction chimique pour dispositif de perfusion implante
US6890553B1 (en) †	1999-07-08	2005-05-10	Johnson & Johnson Consumer Companies, Inc.	Exothermic topical delivery device
US6413238B1 (en)	1999-09-17	2002-07-02	Baxter International Inc	Fluid dispenser with stabilized fluid flow
US7112712B1 (en) *	1999-11-10	2006-09-26	Protex Healthcare (Uk) Limited	Dressing
CA2390131C (fr)	1999-11-29	2009-06-23	Hill-Rom Services, Inc.	Appareil de traitement de plaies
GB2359755A (en) †	2000-03-03	2001-09-05	Mediplus Ltd	Apparatus for assisting wound healing
US6520982B1 (en)	2000-06-08	2003-02-18	Kci Licensing, Inc.	Localized liquid therapy and thermotherapy device
US6855135B2 (en) †	2000-11-29	2005-02-15	Hill-Rom Services, Inc.	Vacuum therapy and cleansing dressing for wounds
JP4408018B2 (ja) †	2001-01-18	2010-02-03	ナワ−ハイルミッテルゲーエムベーハー	包帯材および該包帯材とともに使用される処置溶液
US6575961B2 (en) *	2001-02-20	2003-06-10	Microlin, L.C.	Fluid delivery device and associated method
US7004915B2 (en) *	2001-08-24	2006-02-28	Kci Licensing, Inc.	Negative pressure assisted tissue treatment system
US6723077B2 (en)	2001-09-28	2004-04-20	Hewlett-Packard Development Company, L.P.	Cutaneous administration system
US20030149406A1 (en) †	2002-02-07	2003-08-07	Lucie Martineau	Multi-layer dressing as medical drug delivery system
GB0224986D0 (en) †	2002-10-28	2002-12-04	Smith & Nephew	Apparatus
EP1583493B1 (fr) †	2002-12-31	2015-05-06	BSN medical GmbH	Pansement de plaie
AT413649B (de)	2003-08-04	2006-04-15	Pro Med Medizinische Produktio	Vorrichtung zur dosierten abgabe einer flüssigkeit
US7470266B2 (en) †	2003-09-16	2008-12-30	I-Flow Corporation	Fluid medication delivery device
GB0325130D0 (en) *	2003-10-28	2003-12-03	Smith & Nephew	Apparatus with scaffold
GB0409443D0 (en) †	2004-04-28	2004-06-02	Smith & Nephew	Apparatus
GB0518825D0 (en) †	2005-09-15	2005-10-26	Smith & Nephew	Apparatus with actives from tissue - sai
US8257393B2 (en)	2003-12-04	2012-09-04	Ethicon, Inc.	Active suture for the delivery of therapeutic fluids
US7316817B2 (en) †	2004-01-02	2008-01-08	New Medical Technologies, Inc.	Method and device for topical delivery of therapeutic agents to the skin
GB0508531D0 (en) †	2005-04-27	2005-06-01	Smith & Nephew	Sai with ultrasound
GB0508529D0 (en) †	2005-04-27	2005-06-01	Smith & Nephew	Sai with microstress
GB0409446D0 (en) †	2004-04-28	2004-06-02	Smith & Nephew	Apparatus
GB0417138D0 (en) †	2004-07-31	2004-09-01	Bradford Teaching Hospitals Nh	Wound simulation device
US7612247B2 (en)	2004-09-29	2009-11-03	Oyaski Michael F	Wound alternative treatment system
US7837673B2 (en) *	2005-08-08	2010-11-23	Innovative Therapies, Inc.	Wound irrigation device
JP5149201B2 (ja) †	2006-01-23	2013-02-20	ケーシーアイライセンシングインク	超音波デブリドマンを使用した傷を治療するシステム及び方法

2008
- 2008-12-22 US US12/341,832 patent/US20090216204A1/en not_active Abandoned
- 2008-12-22 WO PCT/US2008/088044 patent/WO2009108250A2/fr not_active Ceased
- 2008-12-22 EP EP08872795.3A patent/EP2244746B2/fr not_active Not-in-force
2014
- 2014-06-16 US US14/305,995 patent/US10279156B2/en active Active
2019
- 2019-01-11 US US16/245,867 patent/US11497652B2/en active Active

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3951147A (en) *	1975-04-07	1976-04-20	Metal Bellows Company	Implantable infusate pump
US4382441A (en) *	1978-12-06	1983-05-10	Svedman Paul	Device for treating tissues, for example skin
US20050177118A1 (en) *	1994-05-13	2005-08-11	Hoganson David M.	Resorbable polymeric device for localized drug delivery
US5785688A (en) *	1996-05-07	1998-07-28	Ceramatec, Inc.	Fluid delivery apparatus and method
US20020128578A1 (en) *	1997-08-01	2002-09-12	3M Innovative Properties Company	Medical article having fluid control film
US6458109B1 (en) *	1998-08-07	2002-10-01	Hill-Rom Services, Inc.	Wound treatment apparatus
US20020150720A1 (en) *	2001-04-16	2002-10-17	Howard Pamela A.	Wound dressing system
US20030108587A1 (en) *	2001-05-15	2003-06-12	Orgill Dennis P.	Methods and apparatus for application of micro-mechanical forces to tissues
US20030204329A1 (en) *	2002-04-24	2003-10-30	Marchitto Kovin S.	Feedback control device for transcutaneous drug delivery and uses therefor

Cited By (110)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US9220822B2 (en)	2007-11-21	2015-12-29	Smith & Nephew Plc	Wound dressing
US10123909B2 (en)	2007-11-21	2018-11-13	Smith & Nephew Plc	Wound dressing
US10016309B2 (en)	2007-11-21	2018-07-10	Smith & Nephew Plc	Wound dressing
US9962474B2 (en)	2007-11-21	2018-05-08	Smith & Nephew Plc	Vacuum assisted wound dressing
US9956121B2 (en)	2007-11-21	2018-05-01	Smith & Nephew Plc	Wound dressing
US12491121B2 (en)	2007-11-21	2025-12-09	Smith & Nephew Plc	Wound dressing
US8715256B2 (en)	2007-11-21	2014-05-06	Smith & Nephew Plc	Vacuum assisted wound dressing
US12290627B2 (en)	2007-11-21	2025-05-06	Smith & Nephew Plc	Wound dressing
US10744041B2 (en)	2007-11-21	2020-08-18	Smith & Nephew Plc	Wound dressing
US8808274B2 (en)	2007-11-21	2014-08-19	Smith & Nephew Plc	Wound dressing
US10231875B2 (en)	2007-11-21	2019-03-19	Smith & Nephew Plc	Wound dressing
US12285318B1 (en)	2007-11-21	2025-04-29	Smith & Nephew Plc	Vacuum assisted wound dressing
US11045598B2 (en)	2007-11-21	2021-06-29	Smith & Nephew Plc	Vacuum assisted wound dressing
US11110010B2 (en)	2007-11-21	2021-09-07	Smith & Nephew Plc	Wound dressing
US9844475B2 (en)	2007-11-21	2017-12-19	Smith & Nephew Plc	Wound dressing
US11974902B2 (en)	2007-11-21	2024-05-07	Smith & Nephew Plc	Vacuum assisted wound dressing
US8764732B2 (en)	2007-11-21	2014-07-01	Smith & Nephew Plc	Wound dressing
US11701266B2 (en)	2007-11-21	2023-07-18	Smith & Nephew Plc	Vacuum assisted wound dressing
US10555839B2 (en)	2007-11-21	2020-02-11	Smith & Nephew Plc	Wound dressing
US11364151B2 (en)	2007-11-21	2022-06-21	Smith & Nephew Plc	Wound dressing
US11351064B2 (en)	2007-11-21	2022-06-07	Smith & Nephew Plc	Wound dressing
US11129751B2 (en)	2007-11-21	2021-09-28	Smith & Nephew Plc	Wound dressing
US11179276B2 (en)	2007-11-21	2021-11-23	Smith & Nephew Plc	Wound dressing
US10299966B2 (en)	2007-12-24	2019-05-28	Kci Usa, Inc.	Reinforced adhesive backing sheet
US12097094B2 (en)	2008-03-05	2024-09-24	Solventum Intellectual Properties Company	Dressing and method for applying reduced pressure to and collecting and storing fluid from a tissue site
US11020516B2 (en)	2008-03-05	2021-06-01	Kci Licensing, Inc.	Dressing and method for applying reduced pressure to and collecting and storing fluid from a tissue site
US10010656B2 (en)	2008-03-05	2018-07-03	Kci Licensing, Inc.	Dressing and method for applying reduced pressure to and collecting and storing fluid from a tissue site
US20090264838A1 (en) *	2008-04-21	2009-10-22	Enzysurge Ltd.	Liquid streaming devices for treating wounds, method of making such devices, and method of using such devices for treating wounds
US20110046577A1 (en) *	2008-04-21	2011-02-24	Enzysurge Ltd.	Liquid streaming devices and method of using such devices for treating wounds
US9044532B2 (en)	2008-04-21	2015-06-02	Enzysurge Ltd.	Liquid streaming devices and method of using such devices for treating wounds
US8491548B2 (en)	2008-04-21	2013-07-23	Enzysurge Ltd.	Liquid streaming devices and method of using such devices for treating wounds
US8241260B2 (en) *	2008-04-21	2012-08-14	Enzysurge Ltd.	Liquid streaming devices for treating wounds, method of making such devices, and method of using such devices for treating wounds
US10905594B2 (en)	2008-10-29	2021-02-02	Kci Licensing, Inc.	Reduced-pressure, abdominal treatment systems and methods
US11246758B2 (en)	2008-10-29	2022-02-15	Kci Licensing, Inc.	Open-cavity, reduced-pressure treatment devices and systems
US10350114B2 (en) *	2008-10-29	2019-07-16	Kci Licensing, Inc.	Open-cavity, reduced-pressure treatment devices and systems
US9259558B2 (en) *	2009-01-15	2016-02-16	Convatec Technologies, Inc.	Aspirated wound dressing
US20110276016A1 (en) *	2009-01-15	2011-11-10	Mingliang Lawrence Tsai	Aspirated wound dressing
US10279088B2 (en)	2010-03-16	2019-05-07	Kci Licensing, Inc.	Delivery-and-fluid-storage bridges for use with reduced-pressure systems
US11400204B2 (en)	2010-03-16	2022-08-02	Kci Licensing, Inc.	Delivery-and-fluid-storage bridges for use with reduced-pressure systems
US20140330227A1 (en)	2010-03-16	2014-11-06	Kci Licensing, Inc.	Delivery-and-fluid-storage bridges for use with reduced-pressure systems
US10568767B2 (en)	2011-01-31	2020-02-25	Kci Usa, Inc.	Silicone wound dressing laminate and method for making the same
US10357406B2 (en)	2011-04-15	2019-07-23	Kci Usa, Inc.	Patterned silicone coating
US12279932B2 (en)	2011-12-16	2025-04-22	Solventum Intellectual Properties Company	Releasable medical drapes
US10940047B2 (en)	2011-12-16	2021-03-09	Kci Licensing, Inc.	Sealing systems and methods employing a hybrid switchable drape
US9861532B2 (en)	2011-12-16	2018-01-09	Kci Licensing, Inc.	Releasable medical drapes
US11944520B2 (en)	2011-12-16	2024-04-02	3M Innovative Properties Company	Sealing systems and methods employing a hybrid switchable drape
US11969318B2 (en)	2011-12-16	2024-04-30	Solventum Intellectual Properties Company	Releasable medical drapes
US10945889B2 (en)	2011-12-16	2021-03-16	Kci Licensing, Inc.	Releasable medical drapes
WO2013138325A1 (fr) *	2012-03-12	2013-09-19	Ivwatch, Llc	Pansement pour un site d'insertion d'un perfusat intravasculaire
WO2014031491A3 (fr) *	2012-08-23	2014-05-30	Nioxx Llc	Production prolongée d'oxyde nitrique à partir de réactifs chimiques microencapsulés
US9445996B2 (en)	2012-08-23	2016-09-20	Nioxx Llc	Extended production of nitric oxide from a microencapsulated nitrite salt and an aqueous acidified gel
US12156786B2 (en)	2012-11-16	2024-12-03	Solventum Intellectual Properties Company	Medical drape with pattern adhesive layers and method of manufacturing same
US10842707B2 (en)	2012-11-16	2020-11-24	Kci Licensing, Inc.	Medical drape with pattern adhesive layers and method of manufacturing same
US11839529B2 (en)	2012-11-16	2023-12-12	Kci Licensing, Inc.	Medical drape with pattern adhesive layers and method of manufacturing same
US11395785B2 (en)	2012-11-16	2022-07-26	Kci Licensing, Inc.	Medical drape with pattern adhesive layers and method of manufacturing same
US10271995B2 (en)	2012-12-18	2019-04-30	Kci Usa, Inc.	Wound dressing with adhesive margin
US11141318B2 (en)	2012-12-18	2021-10-12	KCl USA, INC.	Wound dressing with adhesive margin
AU2014216501A8 (en) *	2013-02-12	2018-09-20	Electrochemical Oxygen Concepts, Inc.	Dressing for wound treatment
JP2016511029A (ja) *	2013-02-12	2016-04-14	エレクトロケミカルオキシジェンコンセプツインコーポレーテッド	創傷処置用被覆材
AU2014216501B2 (en) *	2013-02-12	2018-05-17	Electrochemical Oxygen Concepts, Inc.	Dressing for wound treatment
CN105073077A (zh) *	2013-02-12	2015-11-18	电化学氧概念公司	用于伤口治疗的敷料
AU2014216501B8 (en) *	2013-02-12	2018-09-20	Electrochemical Oxygen Concepts, Inc.	Dressing for wound treatment
WO2014126888A3 (fr) *	2013-02-12	2015-02-26	Electrochemical Oxygen Concepts, Inc.	Pansement pour traitement des plaies
US10105265B2 (en)	2013-02-12	2018-10-23	Electrochemical Oxygen Concepts, Inc.	Dressing for wound treatment
US20170100565A1 (en) *	2013-03-15	2017-04-13	Boston Scientific Scimed, Inc.	Methods and systems for treatment of a bladder
US10315005B2 (en) *	2013-03-15	2019-06-11	Boston Scientific Scimed, Inc.	Methods and systems for treatment of a bladder
EP3030206A4 (fr) *	2013-08-07	2017-03-15	Plurogen Therapeutics, LLC	Administration de médicaments par pansement à pression négative continue
US10946124B2 (en)	2013-10-28	2021-03-16	Kci Licensing, Inc.	Hybrid sealing tape
US11154650B2 (en)	2013-10-30	2021-10-26	Kci Licensing, Inc.	Condensate absorbing and dissipating system
US20150119831A1 (en)	2013-10-30	2015-04-30	Kci Licensing, Inc.	Condensate absorbing and dissipating system
US12324725B2 (en)	2013-10-30	2025-06-10	Solventum Intellectual Properties Company	Dressing with sealing and retention interface
US9925092B2 (en)	2013-10-30	2018-03-27	Kci Licensing, Inc.	Absorbent conduit and system
US10398814B2 (en)	2013-10-30	2019-09-03	Kci Licensing, Inc.	Condensate absorbing and dissipating system
US11793923B2 (en)	2013-10-30	2023-10-24	Kci Licensing, Inc.	Dressing with differentially sized perforations
US9956120B2 (en)	2013-10-30	2018-05-01	Kci Licensing, Inc.	Dressing with sealing and retention interface
US11964095B2 (en)	2013-10-30	2024-04-23	Solventum Intellectual Properties Company	Condensate absorbing and dissipating system
US10016544B2 (en)	2013-10-30	2018-07-10	Kci Licensing, Inc.	Dressing with differentially sized perforations
US10967109B2 (en)	2013-10-30	2021-04-06	Kci Licensing, Inc.	Dressing with differentially sized perforations
US11744740B2 (en)	2013-10-30	2023-09-05	Kci Licensing, Inc.	Dressing with sealing and retention interface
US10940046B2 (en)	2013-10-30	2021-03-09	Kci Licensing, Inc.	Dressing with sealing and retention interface
US10849792B2 (en)	2013-10-30	2020-12-01	Kci Licensing, Inc.	Absorbent conduit and system
US10632020B2 (en)	2014-02-28	2020-04-28	Kci Licensing, Inc.	Hybrid drape having a gel-coated perforated mesh
US12127917B2 (en)	2014-03-03	2024-10-29	Solventum Intellectual Properties Company	Low profile flexible pressure transmission conduit
US20150245950A1 (en) *	2014-03-03	2015-09-03	Kci Licensing, Inc.	Low profile flexible pressure transmission conduit
US11026844B2 (en) *	2014-03-03	2021-06-08	Kci Licensing, Inc.	Low profile flexible pressure transmission conduit
US10406266B2 (en)	2014-05-02	2019-09-10	Kci Licensing, Inc.	Fluid storage devices, systems, and methods
US10561534B2 (en)	2014-06-05	2020-02-18	Kci Licensing, Inc.	Dressing with fluid acquisition and distribution characteristics
US11957546B2 (en)	2014-06-05	2024-04-16	3M Innovative Properties Company	Dressing with fluid acquisition and distribution characteristics
US11633551B2 (en)	2014-11-13	2023-04-25	Hansen Pharmaceutical, Llc	Gaseous nitric oxide delivery system and methods of use
US20160136364A1 (en) *	2014-11-13	2016-05-19	Barry university	Nitric oxide delivery system and methods of use
US10391266B2 (en) *	2014-11-13	2019-08-27	Hansen Pharmaceutical, Llc	Nitric oxide delivery system and methods of use
US12226289B2 (en)	2014-12-17	2025-02-18	Solventum Intellectual Properties Company	Dressing with offloading capability
US10398604B2 (en)	2014-12-17	2019-09-03	Kci Licensing, Inc.	Dressing with offloading capability
US10456416B2 (en)	2015-01-20	2019-10-29	Plurogen Therapeutics, Llc	Compositions and methods of treating microbes
US11246975B2 (en)	2015-05-08	2022-02-15	Kci Licensing, Inc.	Low acuity dressing with integral pump
US11096830B2 (en)	2015-09-01	2021-08-24	Kci Licensing, Inc.	Dressing with increased apposition force
US11950984B2 (en)	2015-09-01	2024-04-09	Solventum Intellectual Properties Company	Dressing with increased apposition force
US12220302B2 (en)	2015-09-01	2025-02-11	Solventum Intellectual Properties Company	Dressing with increased apposition force
US10973694B2 (en)	2015-09-17	2021-04-13	Kci Licensing, Inc.	Hybrid silicone and acrylic adhesive cover for use with wound treatment
US12396894B2 (en)	2015-09-17	2025-08-26	Solventum Intellectual Properties Company	Hybrid silicone and acrylic adhesive cover for use with wound treatment
US10383697B2 (en) *	2016-03-13	2019-08-20	Svetlana Karasina	Surgical item counting station and method of use
US20170258547A1 (en) *	2016-03-13	2017-09-14	Svetlana Karasina	Surgical item counting station and method of use
EP3773782A4 (fr) *	2018-05-16	2022-03-02	Midwest Training and Development Services, LLC	Système de pose de pansement sur une plaie à pression négative
US20210267540A1 (en) *	2018-07-17	2021-09-02	Vitestro Holding B.V.	Cannula insertion system
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Publication number	Publication date
US10279156B2 (en)	2019-05-07
US20190247634A1 (en)	2019-08-15
US11497652B2 (en)	2022-11-15
US20140296774A1 (en)	2014-10-02
EP2244746A4 (fr)	2011-06-22
EP2244746B2 (fr)	2019-01-02
EP2244746A2 (fr)	2010-11-03
WO2009108250A2 (fr)	2009-09-03
WO2009108250A3 (fr)	2009-10-22
EP2244746B1 (fr)	2013-07-31

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