US20080195126A1 - Suture and method for repairing a heart - Google Patents

Suture and method for repairing a heart Download PDF

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Publication number: US20080195126A1
Authority: US; United States
Prior art keywords: anchor; heart; elongate member; suture; tissue
Prior art date: 2007-02-14
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Abandoned

Application number

US12/031,490

Other languages

English (en)

Inventor

Jan Otto Solem

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Edwards Lifesciences Corp

Original Assignee

Edwards Lifesciences Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-02-14

Filing date

2008-02-14

Publication date

2008-08-14

2008-02-14 Application filed by Edwards Lifesciences Corp filed Critical Edwards Lifesciences Corp

2008-02-14 Priority to US12/031,490 priority Critical patent/US20080195126A1/en

2008-04-22 Assigned to EDWARDS LIFESCIENCES CORPORATION reassignment EDWARDS LIFESCIENCES CORPORATION ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: SOLEM, JAN OTTO

2008-08-14 Publication of US20080195126A1 publication Critical patent/US20080195126A1/en

2012-10-26 Priority to US13/662,128 priority patent/US20130110230A1/en

2016-08-09 Priority to US15/232,274 priority patent/US9572667B2/en

2017-01-10 Priority to US15/402,603 priority patent/US10154838B2/en

Status Abandoned legal-status Critical Current

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Classifications

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Definitions

the present invention relates generally to medical devices, and more particularly, to implantable medical devices for treating diseases, disorders, and malformations of a heart
the function of the heart may be seriously impaired if any of the heart valves is not functioning properly.
the heart valves may lose their ability to close properly due to disease or defects, such as (for example) by a mitral or tricuspid valve leaflet becoming partially or completely detached from a papillary muscle (e.g., by ruptured chordae tendinae) thereby resulting in prolapsing of the leaflet.
the inability of the heart valve to close will cause a leak backwards, commonly referred to as regurgitation, through the valve.
a traditional surgical suture typically has a needle attached to one or both ends of a thread.
one needle is passed through the tissue one or several times and advanced to about the middle of the thread.
the thread may or may not be knotted at this point to prevent the thread from moving slidingly through the tissue. Whether knotted or not, the end result is that the thread is attached to the tissue.
a first end of a suture thread is attached to a papillary muscle inside the left ventricle of a heart.
the appropriate length of the thread is determined, and the other end of the suture thread is stitched through one or more of the leaflets of the mitral valve for creating artificial chordae tendinae.
This procedure can be performed for treating a regurgitant mitral valve when the reason for the regurgitation (i.e., leak) is prolapse of a mitral valve leaflet into the left atrium.
attaching a thread (i.e., suture) to the papillary muscle can be cumbersome due to difficulties in accessing the surgical site, including limitations in physical and visual access.
the limited visual access results from the relatively narrow space between the leaflets of a mitral valve. Furthermore, access to the desired portion of the heart can be difficult while performing conventional open-heart surgery (i.e., with a sternal split). Further difficulties can arise as a result of the difficult angles at which the instruments are held.
Embodiments of the present invention provide devices and methods for securely attaching a thread to tissue without the need for conventional suturing, thereby eliminating the need for surgical instruments such as needle holders and forceps. Some embodiments are adapted for attaching thread to heart wall tissue; however, the features of the invention are also applicable to a wide variety of other medical procedures wherein it is desirable to securely anchor a suture thread or other structure to a portion of tissue without using a needle and forceps.
Embodiments of the invention include new devices and methods for creating artificial chordae and for repairing various other heart defects without suturing.
embodiments may be used to reduce dilation of a heart wall, such as in the left ventricle.
these treatments are performed in a percutaneous manner by means of catheter access.
a suture device for repairing a human heart comprises a thread, an anchor, and a delivery system.
the anchor is configured to engage tissue, such as tissue of an inner wall of the heart.
the thread is attached to the anchor at one end and configured to be attached (via conventional suture tying, clipping, or otherwise) to heart tissue (such as valve leaflet tissue) at another end.
the delivery system is configured to deliver the anchor in a delivery configuration, and to deploy the anchor into tissue at a desired location (such as at or adjacent papillary muscles of the heart).
the anchor comprises memory materials (such as Nitinol) and/or is biased toward the deployed state so that the anchor is configured to expand from a delivered state to a deployed state when ejected from a distal end of a sheath on the delivery catheter.
memory materials such as Nitinol
the anchor is configured for attachment at or adjacent papillary muscle tissue
the thread is configured to be coupled to the anchor and attached to a leaflet for creating an artificial chordae tendinae.
the delivery system includes a sheath or other structure for delivering the anchor in a collapsed condition to the desired deployment location.
a method for repairing a human heart comprises gaining access to the inner portion of a human heart and deploying a suture anchor. A thread is then attached to tissue and coupled to the anchor. The thread may be foreshortened to a desired length and then locked in the foreshortened position. This method may be used for replacing chordae tendinae, for treating dilation of a left ventricle, or for other heart treatments.
a method of treating mitral valve regurgitation comprises performing open heart surgery for gaining direct access to the left atrium and the mitral valve.
An anchor is deployed along or adjacent to the papillary muscle, and an elongate member (e.g., thread) is attached at a first end to the anchor and at a second end to a mitral valve leaflet.
the length of the elongate member may be adjusted to close a gap in the mitral valve, and the thread is then knotted or otherwise locked to the mitral valve leaflet to maintain the desired length.
a method of treating an enlargement of a left ventricle of a heart comprises accessing the inside of a heart (e.g., through surgical incision) and deploying multiple anchor members at locations along the left ventricular muscular wall. Threads extending from the anchor members are connected to a lock. The threads are shortened to pull the anchors, and therefore the muscular wall, into closer proximity to the lock and to the other anchors. The threads are then locked in the shortened condition to maintain the anchors in closer proximity, thereby reducing the size of the left ventricle.
the lock is located within the left ventricle.
the lock is located within a different chamber of the heart, such as the right atrium or the right ventricle.
the lock is located outside of the heart, such as, for example, at or adjacent the apex of the heart.
a method of treating an enlargement of a ventricle of a heart comprises accessing the inside of a heart via a percutaneous or surgical incision, deploying anchors in the left ventricular muscular wall wherein suture threads extend from the anchors, and connecting the suture threads to a lock.
the anchors are allowed to grow into the tissue such that they are securely attached to the heart wall.
the inside of the heart may be re-accessed by means of catheter-based technology for localizing the lock, and the suture threads are then foreshortened and locked.
FIG. 1 shows a cross-sectional view of a human heart with a device according to an embodiment of the invention deployed therein;
FIG. 2A illustrates a device comprising an anchor, an elongate member, and hooks according to an embodiment of the invention
FIG. 2B illustrates a device comprising an anchor and an elongate member according to a further embodiment of the invention
FIG. 2C illustrates a device comprising an anchor and an elongate member according to a further embodiment of the invention
FIG. 3A depicts a device comprising an anchor and rod-like elongate member according to a further embodiment of the invention
FIG. 3B depicts a device similar to that of FIG. 3A with a magnetic connector secured thereto according to an embodiment of the invention
FIGS. 4A and 4B illustrate an expandable anchor, in unexpanded and expanded configurations, respectively, according to an embodiment of the invention
FIGS. 5A through 5D illustrate a method of delivering the device wherein a delivery system comprises a sheath for maintaining the anchor in the collapsed position during advancement according to an embodiment of the invention
FIG. 6 illustrates an embodiment of the invention during implantation wherein a suture thread is stitched through the anterior mitral valve leaflet to create replacement chordae tendinae;
FIG. 7 illustrates a device wherein suture is stitched through the mitral valve annulus for pulling the papillary muscle closer to the annulus, thereby relieving strain on the chordae tendinae according to an embodiment of the invention
FIG. 8A illustrates anchors are configured for engaging the inner wall of the left ventricle and aneurysms according to an embodiment of the invention
FIG. 8B illustrates the device of FIG. 8A after foreshortening and locking the threads for reshaping the left ventricle according to an embodiment of the invention
FIG. 8C illustrates an embodiment of the invention wherein the threads are captured and held in a locking mechanism located outside the left ventricle;
FIG. 8D illustrates an embodiment of the invention wherein the threads are captured and held in a locking mechanism located in the right ventricle along the interventricular septum;
FIG. 9 illustrates a further embodiment of the invention wherein the anchor of the suture is deployed inside a papillary muscle and the elongate member (e.g., thread) is locked inside the right atrium close to the annulus of the mitral valve, thereby closing the papillary muscle to the annulus and relieving tension on the chordae tendinae;
the elongate member e.g., thread
FIG. 10A illustrates a further embodiment of the invention wherein the anchor is located just below the mitral valve in the left ventricle wall and the locking mechanism is located in the right ventricle on the septum, thereby pulling the posterior leaflet from lateral towards the septum and shortening the antero-posterior diameter (also called septo-lateral distance) for repairing a mitral valve leak;
FIG. 10B depicts an embodiment of the invention wherein the anchor is located close to the mitral valve in the ventricular septum and the thread is running through the coronary sinus and the elongate member (e.g., thread) is locked inside the coronary sinus, in the orifice of or just outside the coronary sinus orifice, thereby pulling the posterior leaflet from lateral towards the septum and shortening the anterior-posterior diameter for repairing a mitral valve leak;
the elongate member e.g., thread
FIG. 11 depicts an anchor deployed in a heart according to an embodiment of the invention
FIGS. 12A 12 D depict a method for deploying a device according to an embodiment of the invention
FIG. 13A is a perspective view of a suture deployment device according to an embodiment of the invention.
FIGS. 13B and 13C are top and side views, respectively, in partial cross section of the distal portion of the suture deployment device of FIG. 13A ;
FIG. 14A is a front view of a heart, in cross section, with a suture deployment device advanced to a valve leaflet to deploy suture according to an embodiment of the invention
FIG. 14B-14C are side views, in cross section, of the distal end of the suture deployment device of FIG. 14A deploying suture through valve leaflet tissue;
FIG. 14A is a front view of the heart, in cross section, from FIG. 14A with the suture deployment device having secured suture to the valve leaflet;
FIG. 15 is a front view of a heart, in cross section, with a suture, anchor, and elongate member deployed therein according to an embodiment of the invention
FIG. 16A is a side view of a suture securing and cutting catheter for use in securing suture according to an embodiment of the invention
FIGS. 16B-16D are exploded and assembled views of the distal portion of the suture securing and cutting catheter of FIG. 16A ;
FIGS. 17A and 17 B are front views of a heart, in cross section, with a suture securing and cutting catheter advancing a suture clip along suture lines and an elongate member to form a replacement chordae tendinae according to an embodiment of the invention;
FIG. 17C is a front view of the heart of FIGS. 17A-17B with the suture clip deployed and excess suture removed to form a replacement chordae tendinae according to an embodiment of the invention.
FIGS. 18A-18B are front views of a heart, in cross section, with a suture delivery catheter deploying suture through papillary muscle tissue according to an embodiment of the invention.
a device 10 according to the invention is depicted deployed within a heart 12 .
the heart 12 has four chambers, known as the right atrium 14 , right ventricle 16 , left atrium 18 , and left ventricle 20 .
the device 10 is deployed in the left ventricle 20 .
the heart 12 has a muscular outer wall 22 , with an interatrial septum 24 (not visible in FIG. 1 ) dividing the right atrium 14 and left atrium 18 , and a muscular interventricular septum 26 dividing the right ventricle 16 and left ventricle 20 .
the apex 28 At the base of the heart 12 is the apex 28 .
the tricuspid valve 34 which has three leaflets 36 , controls blood flow between the right atrium 14 and the right ventricle 16 .
the tricuspid valve 34 is closed when blood is pumped out from the right ventricle 16 to the lungs. Thereafter, the tricuspid valve 34 is opened to refill the right ventricle 16 with blood from the right atrium 14 .
Lower portions and free edges 42 of leaflets 36 of the tricuspid valve 34 are connected via tricuspid chordae tendinae 44 to papillary muscles 46 in the right ventricle 16 for controlling the movements of the tricuspid valve 34 .
Blood from the right ventricle 18 is pumped through the pulmonary valve 38 to the pulmonary artery 40 which branches into arteries leading to the lungs.
the newly-oxygenated blood flows through the pulmonary veins 48 and enters the left atrium 18 of the heart 12 .
the mitral valve 50 controls blood flow between the left atrium 18 and the left ventricle 20 .
the mitral valve 50 is closed during ventricular systole when blood is ejected from the left ventricle 20 into the aorta 52 . Thereafter, the mitral valve 50 is opened to refill the left ventricle 20 with blood from the left atrium 18 .
the mitral valve has two leaflets (anterior leaflet 54 a and posterior leaflet 54 p ), lower portions and free edges 56 of which are connected via mitral chordae tendinae 58 to papillary muscles 60 in the left ventricle 20 for controlling the movements of the mitral valve 50 .
Blood from the left ventricle 20 is pumped by power from the musculature of the heart wall 22 and the muscular interventricular septum 26 through the aortic valve 62 into the aorta 52 which branches into arteries leading to all parts of the body.
the treatment device 10 generally comprises an anchor 70 and an elongate member 72 .
the anchor 70 provides a mechanism for attaching the device to an inner heart wall or other deployment site without requiring the use of a suturing needle.
the elongate member 72 is coupled to the anchor 70 , such as by being looped therethrough or by other attachment thereto.
the elongate member 72 may be used for replacing a damaged or ruptured chordae tendinae or may be used for pulling a heart wall inward to reduce dilation of a heart wall.
the elongate member 72 comprises a thread 74 terminating at either end 76 in hooks or needles 78 .
the thread 74 passes through a hoop-like structure 80 on the anchor 70 .
the hooks or needles 78 on the free ends 76 of the thread 74 provide a physician or other user with the ability to penetrate tissue in the heart or elsewhere for fixing the free ends 76 of the elongate member 72 .
thread 74 or other elongate member could terminate at free ends 76 without books, as depicted in FIG. 2B , which could be useful where one or more of the free ends 76 are to be passed through tissue using a detachable needle 82 or similar suturing device.
an elongate member 72 such as one or more threads 74 , could be secured permanently or through other methods to the anchor 70 , such as being secured directly and fixedly to the attachment point 84 depicted in FIG. 2C .
a thread portion of a device 10 may be formed of various materials, including PTFE (polytetrafluoroethylene, aka Goretex®), polypropylene (e.g. Prolene), or other suture materials such as Ti-crone or Ethibond.
PTFE polytetrafluoroethylene
Prolene polypropylene
suture materials such as Ti-crone or Ethibond.
the hooks or needles could be attached to the threads according to known techniques, including techniques applied by suture material producers.
FIG. 3A depicts a further embodiment of the invention, wherein the elongate member 72 comprises a rod-like structure 86 .
the rod-like structure 86 is generally cylindrical, although other configurations are also possible.
the rod-like structure 86 may be solid or hollow, depending on the particular configuration and application.
the rod-like structure 86 may be generally rigid or may be generally flexible, or may be configured to be partially rigid but still have some flexibility so that it acts as a shock-absorbing structure when under compression.
FIG. 3B depicts a further embodiment of the invention, wherein the elongate member 72 comprises a rod-like structure 86 having a magnet 88 secured at the free end 76 .
the magnet 88 might be used to pick up the elongate member 72 (in the form of a rod 76 or thread, etc.) at a later point of time, e.g., after the anchor has been deployed and grown solid into the tissue and the user desires to pull hard on the elongate member 72 .
the magnet 88 might be used to change an attached part of a device after a long time has passed, such as where the attached part is degenerated and has to be changed (e.g. a lock or a valve).
the magnet 88 may also be used as a guiding aid, for instance when homing in and locking an elongate member (such as a thread) in a lock under open or percutaneous operations when the heart is beating and full of blood.
the anchor portion 100 comprises a tubular body 102 having a distal end 104 and a proximal end 106 , with a plurality of elongated prongs 108 located on the distal end 104 and a coupling member 110 located on the proximal end 106 .
the coupling member 110 takes the form of a loop.
the elongated prongs 108 may be configured to self-expand from the compressed configuration of FIG. 4A to a “flowered” or expanded configuration of FIG. 4B . This expansion may be achieved with a self-curving area 112 that deflects the elongated prongs 108 radially outward from the center of the generally tubular body 102 .
the prongs 108 may be pointed and/or barbed to facilitate penetration of and engagement with the muscular wall of the heart.
the anchor portion 100 may be formed from various materials and/or combinations thereof.
the anchor portion 100 is formed from a single tube of shape memory material, such as, for example, Nitinol.
shape memory material such as, for example, Nitinol.
the shape memory material or other material forming the anchor portion 100
the shape memory material may be cut using a mechanical or laser cutting tool. After cutting the tube, the expanded or flowered shape can be imparted to the memory of the shape memory material with techniques known in the art (e.g. heat setting the shape).
the anchor 100 is not limited to construction from Nitinol or other shape memory materials, and could be formed from any number of materials, including metals, plastics, composite structures, etc.
All or part of the surface of the anchor portion 100 may be configured to promote tissue growth onto and even into its surface. In one example this growth is achieved by providing a relatively rough and/or porous surface along the anchor portion 100 . Another example is to have one or multiple holes 114 drilled through the anchor portion 100 and its prongs 108 , allowing scar tissue fibrocytes to grow through these holes 114 and thereby add strength to the fixation. Additionally, biological coatings of the types known in the art can be included on the surface of the anchor portion 100 to promote healing and tissue growth.
an anchor portion 100 is secured within a distal end portion 120 of an anchor delivery catheter 122 .
the distal end portion 120 includes a distal end sheath 124 that surrounds the anchor portion 100 and maintains the anchor portion 100 in a compressed configuration during delivery to a treatment site.
the anchor delivery catheter 122 may also includes an expandable structure such as an expandable balloon 126 , which in the embodiment depicted is positioned around a portion of the distal end sheath 124 .
the anchor delivery catheter distal end portion 120 containing the anchor portion 100 is advanced through a chest wall and through the cardiac tissue (or through other delivery routes) into a desired heart chamber.
the expandable balloon 126 can be expanded, as depicted in FIG. 5B .
the expandable balloon 126 when expanded may be just a little smaller than the valve orifice, but larger than the distance between chordae tendinae and allow advancement of the anchor delivery catheter distal end portion 120 past the chordae tendinae and other sub-valvular structures by preventing the anchor delivery catheter distal end portion 120 from becoming entangled within or otherwise passing between such structures in an undesired manner.
the distal end sheath 124 opening remains in contact with the target location while the anchor portion 100 is pushed distally with respect to the distal end portion 120 by means of pushing on the rod 86 or 72 at the proximal end of the delivery catheter 122 , as illustrated in FIGS. 5C and 5D .
the prongs 108 expand outwardly.
the expansion of the prongs 108 to tissue may advantageously pull the anchor portion 100 out of the anchor delivery catheter 122 and outer sheath 126 and dig into the tissue by its inherent force.
a light push forward on the delivery catheter 122 can enable a continuous tissue contact of the delivery catheter orifice 124 to ensure tissue contact with the prongs 108
the prongs 108 on the anchor portion 100 may continue to expand, bending back around towards the generally tubular body 102 while grabbing nearby heart tissue. This tissue-engaging action by the prongs 108 can help to maintain the anchor portion 100 in a stable position within the heart that resists movement due to heart beats, blood flow, and similar actions.
the anchor portion 100 may at least partially “self-deploy” within the heart, requiring little or no extra pressure from the anchor delivery catheter 122 to anchor within the muscular wall of the heart.
FIGS. 5C and 5D depict the expandable balloon 126 in a deflated condition during deployment (which may be preferable in some applications), the expandable balloon 126 (if present) may alternatively be left inflated during deployment of the anchor portion 100
the elongate member 72 took the form of an elongated rod-like structure 86 secured to the anchor portion 100 via an anchor portion connection in the form of a screw-like connection 130 .
the elongated rod-like structure 86 can be relatively thick and configured to transmit axially rotational movement along its length.
the user can rotate a proximal portion of the elongated rod-like structure 86 (or a proximal portion of a wire secured to the proximal end of the elongated rod-like structure 86 , wherein the wire may be positioned outside of the patient's body), thereby causing a corresponding rotation of the distal portion of the elongated rod-like structure 86 and the screw-like connection 130 to the anchor portion 100 .
This rotation will essentially unscrew the screw-like connection 130 , thereby disconnecting the elongated rod-like structure 86 from the anchor portion 100 .
the elongate member 72 can also serve to retract the anchor portion 100 back into the distal end sheath 124 during or after deployment thereof.
the user can pull on the elongated rod-like structure 86 while holding still or even advancing the distal end sheath 124 .
inward pressure on the prongs 108 from the distal end sheath 124 will cause the prongs 108 of the anchor portion 100 to collapse inwardly, thereby collapsing the anchor portion 100 back to its delivery (i.e., predeployment) condition as the anchor portion 100 is pulled back into the distal end sheath 124 .
the user can then redeploy the anchor portion 100 in a new position, or can remove the anchor portion 100 entirely from the patient.
the anchor portion can be implanted without having the elongate member attached thereto during the implantation procedure.
the elongate member could be secured to the anchor portion after the anchor portion is deployed.
the anchor portion can be deployed with an elongate member secured thereto, but then after the implantation a surgeon or other user could remove the original elongate member and replace it with a substitute elongate member.
a thread elongated member 72 may be attached to the anchoring portion permanently while the stiff elongated member 86 is detached.
FIG. 6 depicts an embodiment of a chordae tendinae replacement procedure using a device 10 according to an embodiment of the invention, wherein an anchor 100 is shown after deployment in a papillary muscle 60 , thereby completing the first stage of the implantation procedure.
the two free ends 76 of the suture threads 74 can then be passed (via, e.g., needles 78 ) through a leaflet (which is a posterior leaflet 54 p in the particular embodiment depicted) of the mitral valve 50 (or other tissue, depending on the particular application) by the surgeon or other user.
the threads 74 are knotted or locked by other fixation means like a suture clip or locking mechanism.
the device could be used to replace chordae tendinae of the posterior leaflet 54 p and/or anterior leaflet 54 a of the mitral valve 50 , or of any other leaflet of other valves.
a papillary muscle 60 may have moved away from the mitral valve annulus 51 and thereby be pulling the corresponding leaflet down into the ventricle.
the two leaflets 54 a , 54 p can no longer meet properly, and regurgitation through the valve 50 may occur.
the anchor can be deployed at or adjacent to the papillary muscle, and one or more of the suture ends 76 may be attached to the valve annulus 51 (instead of to the valve leaflets 54 a , 54 p ), thereby shortening the distance between the displaced papillary muscle 60 and the annulus 51 and thereby allowing the leaflets 54 a , 54 p to meet again and the valve 50 to again be competent.
FIGS. 8A and 8B depict a method of treating myocardial infarction, a condition which occurs regularly after blockage of the arteries, resulting in heart muscle cell death.
a weakening of a portion of the heart wall 22 or other structure may occur, with a corresponding bulge or other structural deformation to the heart portion.
a considerable dilation or bulge can occur in the left ventricular wall area 23 .
the left ventricle 20 With each heart contraction in systole, the left ventricle 20 will bulge outwards instead of properly contracting, causing less blood to leave into the aorta and thereby causing low cardiac output and heart failure.
the current invention may be used to treat this condition.
multiple anchors 100 may be deployed in the left ventricular wall area 23 .
the suture threads 74 can be collected in the center by means of a knot or other locking mechanism (such as a suture clip 140 ) and each thread 74 may be pulled inwards toward the center until the bulging is adequately reduced.
the suture threads 74 or other elongate members are then locked via the knot or other locking mechanism to maintain the left ventricle 20 in the reshaped condition, as depicted in FIG. 8B .
FIG. 8C illustrates an alternative configuration for treating a weakened heart wall area 23 , wherein the threads 74 are pulled and locked at a location outside of the heart wall 22 .
the suture clip 140 is positioned at the apex 28 .
FIG. 8D illustrates a further embodiment of the invention, wherein the suture threads 74 are passed through the ventricular septum 26 and into the right ventricle 16 .
the suture threads 74 are then collected on the opposite (i.e., right ventricle) side of the ventricular septum 16 , and each thread 74 may be pulled until the bulging is overcome.
the suture threads 74 can then be locked in the desired position by means of a locking mechanism, such as the suture clip 140 depicted
a similar treatment may also be applied to papillary muscles that have dislocated outwards due to myocardial infarction, thereby causing the mitral valve to leak.
a thread or threads may be passed through the papillary muscle and then through the ventricular septum.
the thread or threads As the thread or threads are tightened, they will cause inwards movement of the papillary muscle and thereby cause the mitral valve to be competent again, at which point the thread or threads can be locked on the right side of the septum by means of a locking mechanism, e.g., a knot or other fixation mechanism.
a locking mechanism e.g., a knot or other fixation mechanism.
FIG. 9 another alternative embodiment is illustrated wherein the anchor 100 is deployed inside a papillary muscle 60 , and the elongate member 72 (e.g., suture thread 74 ) is locked via a suture clip 140 inside the right atrium 14 , e.g., at a location close to the annulus 51 of the mitral valve 50 , thereby pulling the papillary muscle 60 toward the annulus 51 and relieving pressure on the chordae tendinae 58 .
a suture arrangement could treat left ventricular bulging, papillary muscle displacement and mitral regurgitation simultaneously.
FIG. 10A another alternative embodiment is illustrated wherein an anchor 100 is deployed in the heart wall 22 just below the mitral valve 50 , and the suture thread 74 (or other elongate member) is locked via a suture clip 140 in the right ventricle 16 on the interventricular septum 26 , with tension in the suture thread 74 pulling the posterior mitral leaflet 54 p from lateral towards the interventricular septum 26 and thereby shortening the antero-posterior diameter of the mitral valve annulus 51 to repair a mitral valve leak.
the suture thread 74 or other elongate member
an anchor may be deployed in the heart wall adjacent the left atrium, just above or otherwise adjacent the mitral valve, adjacent to or in the mitral valve annulus, and the suture thread (or other elongate member) can be locked via a suture clip in the right atrium on the atrial septum, with tension in the suture thread pulling the posterior mitral leaflet from lateral towards the atrial septum and thereby shortening the antero-posterior diameter of the mitral valve annulus to repair a mitral valve leak.
FIG. 10B yet another embodiment is illustrated wherein the anchor 100 is located adjacent the mitral valve 50 .
the particular embodiment of FIG. 10B depicts anchor deployment in the interventricular septum 26 , although other deployment locations (such as in the heart wall 22 in an area adjacent an upper portion of the left ventricle 20 ) are also within the scope of the invention.
the anchor 100 may be deployed by means of a catheter (such as the delivery catheter 122 from FIGS. 5A-5D ) from inside the coronary sinus 25 .
the anchor 100 can be advanced out of the distal end sheath 124 so the prongs 108 are exposed to the coronary sinus wall and released to dig into the left ventricular wall 22 through the coronary sinus wall.
the elongate member 72 in the form of a suture thread 74 passes from the anchor 100 and runs along the inside of the coronary sinus and extends out from the ostium 27 of the coronary sinus 25 into the right atrium, thereby at least partially encircling the mitral valve annulus 51 .
the free end 76 of the suture thread 74 is locked in or outside of the coronary sinus 25 by means of a suture knot or lock (not shown), pulling the mitral valve posterior leaflet 54 p from lateral towards the interatrial septum 24 and thereby shortening the antero-posterior diameter of the mitral valve annulus 51 to repair a mitral valve leak.
the treatments described herein may demand robust attachment strength.
a two stage procedure might be preferred.
the device may be provided with a coupling member to attach and/or release the elongate member to/from the anchor.
the coupling member provides a point of attachment for connecting an elongate member, such as a suture thread, to the anchor during a second or later implantation stage.
the thread portion may be delivered into the heart by means of a catheter-based technique, similar to that described above with respect to FIGS. 5A-5D .
the elongate member is delivered into the heart using a delivery catheter and is subsequently coupled to the previously-deployed anchor or to a first part of another elongate member already attached to a coupling member of the pre-deployed anchor.
an anchor portion 100 is shown some time after anchor deployment into the muscular heart wall 22 of the left ventricle 20 (i.e., after the first stage of the implantation procedure).
endocardial tissue 150 has grown over the exposed tubular portion 152 of the anchor portion 100 that is protruding from the muscular wall 22 into the left ventricle 20 , preferably leaving only the anchor coupling member 110 exposed within the left ventricle 20 .
a scarring healing takes place, wherein fibrocytes create strong scarring tissue surrounding the prongs 108 , thereby integrating them with the muscle of the heart wall 22 to create a very strong attachment.
the coupling member 110 provides a point of attachment for connecting an elongate member 72 (such as the suture threads 74 and rod-like members 86 previously described embodiments) during a second or later implantation stage.
an elongate member 72 such as the suture threads 74 and rod-like members 86 previously described embodiments
FIG. 11 does not depict an elongate member (such as a suture thread 74 or rod-like member 86 from earlier embodiments) as being present—the reason being that the elongate member is to be attached as a second or later stage of a multi-stage procedure. While a user may be able to couple the elongate member to the previously-deployed anchor portion by simply searching around the patient's heart, additional techniques can be used to facilitate this procedure.
both the coupling member on the anchor and an attachment mechanism of the thread portion may be magnetized, thereby allowing the two to be drawn together when in close proximity.
a vacuum-assisted connection can be used to facilitate connection of the elongate member to the anchor.
anchor lines could be used, such as where an anchor line (e.g., a suture thread) is left secured to the coupling member of the anchor during the first implantation stage (i.e., anchor deployment) and left within the patient for use during the second stage (i.e., attaching the elongate member to the anchor).
the locking mechanism of the elongate member portion can be advanced along the guide element (e.g., originally-deployed suture thread or wire, etc.) until the locking mechanism reaches the coupling member of the previously-deployed anchor.
the guide element e.g., originally-deployed suture thread or wire, etc.
the elongate member 72 may be delivered into the heart using a multi-stage procedure similar to that depicted in FIGS. 12A-12D ) wherein an anchor portion 100 is deployed in the first stage, and then the elongate member 72 is advanced to the site and connected to the anchor portion 70 in situ.
an anchor deployment catheter 160 is shown having a distal end 162 advanced to a desired deployment site within the left ventricle 20 .
the anchor portion 100 is positioned at the anchor deployment catheter distal end 162 , and more specifically is contained within the anchor deployment catheter distal end 162 .
the anchor portion 100 includes multiple anchor members 108 configured to expand outward and embed within the heart tissue when released from the anchor deployment catheter 160 , which can be accomplished by pushing the anchor portion 100 out of the anchor deployment catheter 160 and/or withdrawing the anchor deployment catheter 160 from around the anchor portion 100 .
the anchor portion 100 has been deployed, with the anchor members 108 embedded into the heart tissue in the lower portion of the left ventricle 20 adjacent the apex 28 .
the anchor portion 100 has a top portion 152 having an anchor connector 110 configured to received a mating connector from an elongate member which will be deployed in the second stage (discussed below).
the anchor portion 100 also includes an anchor line opening 164 , which is a loop or lumen through which an anchor line 166 can be passed.
the particular anchor line 166 depicted in FIG. 12B is a line of suture that passes into the patient and into the heart 12 , passes through the anchor line opening 164 , and then passes back out of the heart 12 and the patient to form a double suture line.
the anchor line 166 is left trailing from the anchor portion 100 and out of the heart 12 and patient. While allowing the anchor portion 100 to heal in over some time, the free ends of the anchor line might also be left under the skin of the patient and then retrieved when needed.
FIG. 12C depicts the second stage of the deployment procedure, wherein the elongate member 72 is advanced into the heart 12 and secured to the anchor portion 100 .
a second deployment catheter 170 to which is secured an elongate member 72 , is advanced to the area in the left ventricle 20 at or adjacent the previously-deployed anchor portion 100 .
the second deployment catheter 170 is an over-the-wire type catheter having an inner lumen configured to permit the anchor line 166 to slidingly pass therethrough. Note, however, that a so-called rapid-exchange type of delivery catheter could also be used.
the second deployment catheter 170 includes a canopy container in the form of a side pocket 174 configured to contain and restrain the elongate member 72 during delivery.
the second deployment catheter 170 is advanced along the anchor line 166 to the anchor portion 100 .
the elongate member 72 includes a distal end 176 having a connector 178 configured to be secured to an anchor portion connector 110 on the exposed upper surface 152 of the anchor portion 100 .
the elongate body portion distal end 176 and connector 178 will be led into alignment and contact with the anchor portion connector 110 .
the elongate body portion connector 178 contacts the anchor portion connector 110 , the two connectors 110 , 178 are connected together.
the connectors may be snap-type or quick-connect connections which automatically connect when the two connectors are brought into contact.
the connectors may be manually operated, and/or may include a release device to permit disconnection at a later time.
connection of the two connectors 110 , 178 effectively secures the anchor portion 100 to the elongate member 72 .
the second deployment catheter 170 can be withdrawn, which will release the elongate member 72 from the side pocket 174 to deploy the elongate member 72 , as depicted in FIG. 12D .
the anchor line 166 is still depicted in position passing through the anchor line loop 164 (although the anchor line 166 could have been removed along with, or even prior to, removal of the second deployment catheter 170 ).
the anchor line 166 can now be removed, which in the case of the double suture line depicted can involve releasing one end of the line that passes outside of the heart, and pulling on the other end passing outside the heart.
the loose end of the double suture line will thus be pulled into the heart 12 and will be pulled out of the anchor line loop 164 , thus releasing the anchor line 166 from the anchor portion 100 .
the free end 76 of the elongate member 72 can be secured to the desired tissue (e.g., a valve leaflet) to complete deployment of the device 10 .
the opening 92 through which the catheters 160 , 170 were advanced into and removed from the heart 12 can be closed using a purse-string suture 94 .
a two-stage deployment device and method such as that depicted in FIGS. 12A-12D could be useful for situations where a user may desire to replace an initially-deployed elongate member. For example, if after the device is entirely deployed in a patient's heart, a user may determine that the initially-deployed elongate member is not of the optimal size/configuration or not optimally secured to desired tissue. Such situations may arise where one or more portions of the patient's heart (e.g., the valve, etc.) has deformed since the initial deployment procedure. In such a situation, a user could remove the initially deployed elongate member while leaving the anchor portion in place.
the initially-deployed elongate member e.g., the valve, etc.
the user could then attach another elongate member to the anchor portion, and secure the free ends of the elongate member as desired. Alternatively, the user could simply leave the initial anchor portion in place without attaching another elongate member thereto. The user could also deploy a second elongate member using a second anchor portion.
Deployment of the device and/or of specific elements thereof can be facilitated with cameras, X-rays, or similar techniques which allow the user to visualize the device elements within the patient.
FIG. 13A depicts a suture deployment device 200 for use in deploying an elongated member, such as a suture line, into a valve leaflet.
the suture deployment device 200 comprises an elongated body 202 , a proximal end 204 having a handle 206 , and a distal end 208 .
FIGS. 13B-13C depict a close-up views of the distal end 208 of the suture deployment device 200 .
a vacuum port 210 is positioned on a side of the distal end 208 and is in fluid communication with a suction lumen 212 passing the length of the suture deployment device and configured to be attached at the device proximal end 204 to a vacuum source (not shown).
the vacuum applied to the vacuum port 210 is controlled by a user via one or more controls 214 positioned on the handle 206 .
Two needles 216 a , 216 b are positioned in needle lumens 218 a , 218 b and configured to be advanced and retracted across the vacuum port 210 .
the needles 216 a , 216 b may be independently controlled for separate advancement and retraction.
the needles 216 a , 216 b are coupled to or otherwise in communication with actuators 220 a , 220 b located on the device handle 206 .
the forward and rearward movement of the actuators 220 a , 220 b results in corresponding longitudinal movement of their respective needles 216 a , 216 b , thereby permitting the first and second needles 216 a , 216 b to extend from and retract into the first and second needle lumens 218 a , 218 b via first and second needle ports 222 a , 222 b .
the first and second needles 216 a , 216 b may be capable of individual and/or simultaneous movement.
a guidewire lumen 224 configured to receive a guidewire 226 or similar guide line therein may be positioned in the suture deployment device 200 , and may pass the length of the device (in a so-called over-the-wire configuration) or may pass only through a portion of the distal end and exit through a side just proximal of the distal end (in a so-called rapid-exchange configuration).
first and second needle-receiving ports 228 a , 228 b may be positioned within or proximate the vacuum port 210 and co-aligned with and opposing the first and second needle ports 222 a , 222 b , respectively.
the first needle-receiving port 228 a is in communication with the first suture lumen 230 a and contains a first needle catch 232 a attached to the first suture portion 234 a that passes into the first suture lumen 230 a .
the second needle-receiving port 228 b is in communication with the second suture lumen 230 b and contains a second needle catch 232 b attached to the second suture portion 234 b that passes into the second suture lumen 230 b.
first and second suture portions 234 a , 234 b may be entirely separate suture lines, or may comprise opposing portions of a single common suture line that forms a loop between the first needle catch 232 a and the second needle catch 232 b . If the first and second suture portions 234 a , 234 b are part of a single common suture line, the first and second needle-receiving ports 228 a , 228 b may form a single opening, and the first and second suture lumens 230 a , 230 b may form a single lumen, in order to permit the single common suture line loop to exit freely from the suture deploying device 200
FIGS. 14A-D depict a method of using the suture deployment device 200 of FIGS. 13A-13C to deploy suture line through a valve leaflet to create a replacement chordae tendinae.
the suture deployment device 200 is introduced into a patient's body until the distal end 208 is advanced into the heart 12 , and more specifically (in the particular embodiment depicted) to a position where the vacuum port 210 is adjacent the posterior mitral valve leaflet 54 p , in which one of the several chordae 58 has ruptured into two separate pieces 58 a , 58 b.
the suture deployment device 200 has been advanced percutaneously in a trans-septal approach, using a guide catheter 240 , via the inferior vena cava 32 and right atrium 14 and through an opening 242 in the atrial septum 24 (or through a patent foramen ovale, not shown) into the left atrium 18 to the desired position adjacent the valve leaflet 54 p , which in the particular embodiment depicted is a posterior leaflet of the mitral valve 50 .
other approaches are also within the scope of the invention, including other percutaneous and minimally invasive approaches, such as approaches via the aorta, superior vena cava, or directly through the outer heart wall, etc.
the same procedure may be used for attachment to an anterior leaflet of the mitral valve.
the suture deployment device 200 uses the vacuum port 210 to grasp the valve leaflet 54 p .
the suture deployment device 200 advances a needle 216 a through the valve leaflet tissue 244 , with the needle 216 a engaging against and becoming secured to a needle catcher 232 a on the far side of the valve leaflet tissue 244 and vacuum port 210 , as depicted in FIG. 14C .
the needle 232 a is then withdrawn back through the valve leaflet tissue 244 , thus dragging the needle catcher 232 a and attached suture line portion 234 a back through the valve leaflet tissue 244 , as depicted in FIG. 14D .
the device distal end 208 is then moved away from the valve leaflet 54 p , with the suture line portion 234 a trailing out of the device 200 , as depicted in FIG. 14E .
FIG. 15 depicts an embodiment wherein an anchor 100 has previously been deployed in a papillary muscle 60 (e.g., using devices and methods such as those previously described with respect to FIG. 11 , etc.), with an elongate member portion in the form of a papillary-anchored suture line 250 passing from the anchor 100 and out of the patient via the left atrium 18 , atrial septum 24 , right atrium 14 , and inferior vena cava 32 , i.e., along the same path through which the suture deployment device 200 was advanced in FIGS. 14A-14E .
the previously-deployed papillary-anchored suture line 250 can actually serve as a guide line over which the suture deployment device 200 can be advanced similar to the technique of FIGS. 14A-14E , but with the papillary-anchored suture line 250 serving as a guide line there may be no need for a guide catheter 240 such as that depicted in FIGS. 14A and 14E .
the suture deployment device 200 can, after having passed a leaflet-secured suture line 234 through a valve leaflet 54 p , be withdrawn from the patient as shown, with the leaflet-secured suture line 234 trailing out of the suture deployment device 200 and eventually out of the patient once the suture deployment device is completely withdrawn from the patient.
FIGS. 16A-16D an embodiment of a suture securing and cutting device 260 is depicted.
the fastener catheter 260 has a generally tubular main body 262 , a proximal end 264 , and a distal end 266 .
the proximal end 264 includes a handle knob 268 .
the distal end 266 includes a suture clip 270 positioned thereon.
the fastener catheter 260 may be manufactured in a variety of shapes, sizes, lengths, widths, and biologically-compatible materials as desired for a particular application.
the generally tubular main body 262 has a longitudinal inner lumen 272 therethrough which terminates in a distal opening 274 .
a longitudinally slidable inner body 276 is slidably positioned within the main body 262 .
the inner body 276 includes an inner tubular member distal end 278 which extends out of the main body distal opening 274 .
the inner tubular member distal end 278 itself includes an inner tubular member distal opening 280 , which leads to an inner body lumen 282 .
the inner body 276 includes a suture recess 284 formed in the side thereof, which in turn is in communication with the inner body lumen 282 .
Inner body 276 also includes a pin 286 extending radially outward therefrom.
the main body 262 has a cutting recess 288 formed in an axial side thereof and a cutting member 290 which, in the embodiment depicted, is on a proximal edge of cutting recess 288 .
a pin recess in the form of a slot 292 extends parallel to the axis of the main body 262 and radially through to main body lumen 272 . The slot 292 is thus configured to receive pin 286 in sliding relation.
the inner body 276 is slidably positioned within main body 262 , such that suture recess 284 is in alignment with cutting recess 288 .
Pin 286 is in slidable communication with slot 292 thereby permitting relative linear motion, but preventing relative rotational motion, between inner body 276 and main body 262 .
a clip 270 is positioned on the inner body distal end 278 , which protrudes from the main body distal opening 274 .
the clip 270 includes a clip distal opening 294 , clip proximal opening 296 , and engagement members 298 . As depicted in FIG.
the clip 270 has been placed on inner member distal end 278 by deflecting the engagement members 298 radially outward until they can be placed around the outer circumference of inner body distal end 278 . Accordingly, the clip 270 is secured to the inner body distal end 278 by means of the frictional engagement between the engagement members 298 and the outer surface of inner body distal end 278 .
Suture 234 extends through the fastener clip 270 , with suture leads 234 a and 234 b extending through the clip distal opening 294 , engagement members 298 , and proximal opening 296 , passing through inner member distal opening 280 and inner member lumen 282 , exiting the inner member 276 via suture recess 284 , and exiting the side of main body 262 through cutting recess 288 .
the inner member 276 can be retracted with respect to the main body member 262 , thereby causing the inner body distal end 278 to be pulled inside the main body member 262 .
the clip 270 will thus be pushed off of the inner body distal end 278 by the main body 262 , at which point the clip engagement members 298 move inwardly to block the clip proximal opening 296 and thereby lock the clip 270 onto the suture 234 .
the retraction of the inner member 276 with respect to the main body member 262 also causes the suture portions 234 a , 234 b to be pinched between the inner member opening 284 and the cutting member 190 , so that the suture portions 234 a , 234 b are cut by the cutting member 290 .
FIGS. 17A-17C depict a method of securing the deployed suture lines 234 , 250 together at a desired length in order to create a replacement chordae tendinae.
the suture securing and cutting device 260 is shown with the distal end 266 being advanced along the previously-deployed suture lines 234 , 250 , with the papillary-anchored suture line 250 serving to guide the suture securing and cutting device 260 into the patient's heart 12 and left ventricle 20 .
the user (such as a surgeon or cardiologist) pulls on the proximal end of the papillary-anchored suture line 250 (which is positioned outside of the patient) to maintain slight tension as the suture securing and cutting device 260 is advanced into the left ventricle 20 .
the user may also pull on the proximal ends of the leaflet-secured suture line 234 to prevent it from being pushed into the patient as the suture securing and cutting device is advanced.
FIG. 17B the suture securing and cutting device distal end 266 , with suture securing clip 270 thereon, is depicted advanced to a desired location in the left ventricle.
the user pulls on the papillary-anchored suture line 250 and/or on the leaflet-secured suture line 234 to achieve a replacement chordae tendinae of a desired length. While adjusting the length of the replacement chordae tendinae, the user can monitor the heart function using various devices known in the art, such as fluoroscopy, radiography, ultrasound, etc. In one example, the user can verify the effectiveness of the replacement chordae tendinae length by monitoring blood flow using radiopaque dyes combined with fluoroscopy or by means of ultrasound.
the user When the user sees via the heart function monitoring system(s) that the heart valve is functioning as desired, the user then knows that the replacement chordae tendinae (formed by the sutures 234 , 250 ) is at the appropriate length. The user can then activate the suture securing and cutting device 266 to release the suture clip 270 so that it secures the sutures 234 , 250 at the desired position, thereby forming the desired replacement chordae tendinae. The user also activates the suture securing and cutting device 266 to cut the excess suture portions away adjacent the clip 270 .
FIG. 17C depicts the clip 270 deployed and the excess portions 234 e , 250 e (i.e., portions proximal of the clip 270 ) of the suture lines 234 , 250 having been cut.
the suture securing and cutting device 266 is being withdrawn from the patient, along with the excess cut-off suture portions 234 e , 250 e .
the deployed suture lines 234 , 250 are held firmly by the clip 270 to serve as a replacement chordae tendinae.
the suture deployment device 200 can be used to secure the suture line 234 directly to the papillary muscle or other heart tissue, and/or to a previously-deployed anchor.
the suture deployment device is used to deploy the suture line 234 through the papillary muscle 60 , as depicted and described with respect to FIGS. 118A-B .
FIG. 18A depicts the suture deployment device 200 having already passed a one portion of suture line 234 a through a valve leaflet 54 p (as was depicted in FIGS. 14A-14E ), and then being maneuvered so that the distal end 208 and vacuum port 210 positioned adjacent a papillary muscle 60 and the vacuum activated, so that the papillary muscle 60 has been grasped and held by the vacuum port 210 .
the suture deployment device distal end 208 is moved from its previous position adjacent the valve leaflet 54 p (i.e., the position depicted in FIGS. 14A-D )
the leaflet-secured suture line 234 a plays out from the suture deployment device 200 .
a needle from the suture deployment device is used to pass a second suture line 234 b through the papillary muscle 60 , using an apparatus and technique such as that depicted in FIGS. 14B-14D that was used to pass the leaflet-secured suture line 234 a through the leaflet 54 p .
needle 216 a could be used to pass the leaflet-secured suture line 234 a through the leaflet 54 p
needle 216 b could be used to pass the papillary-secured suture line 234 b through a portion of the papillary muscle 60 .
a suture clip can then be advanced over the suture line portions 234 a , 234 b and secured at a desired place thereon to create a replacement chordae of the desired length, using devices and methods such as those depicted in FIGS. 16 and 17 A- 17 C.
the leaflet-secured suture line(s) can be secured to the leaflet before, after, or simultaneously with deployment of the papillary-secured suture line(s).
the suture deployment device could be used to secure a papillary-secured suture line or lines directly to the papillary muscle, or to an anchor or other device deployed in the papillary muscle.
the suture deployment device may have a magnet near its distal end to assist in guiding the suture deployment device to an anchor that has a magnet.
the suture deploying method and device can vary.
the suture deploying device could be configured to drive a pledget, barb-like device or similar structure into the leaflet, papillary muscle, and/or anchor, with a suture line being secured to the pledget, barb-like device, or similar structure.
the anchor, suture clip, suture lines, suture deployment device, and/or suture securing/cutting device may include one or more visualization references.
visualization references in the form of radiopaque marker bands may be positioned on or adjacent the distal end of the suture deployment device and/or suture securing/cutting device, and/or on the anchor, etc.
the radiopaque marker bands are viewable under a fluoroscope, so that a surgeon or other user can use a fluoroscope to visualize the positions of the devices and anchors within the patient and with respect to any devices present, such as guidewires, etc.
the visualization markers on a particular device may be identical or may be different from each other.
Radiopaque marker bands or other visualization references that provide different radiopaque or other visualization signatures permit a user to differentiate between particular elements (e.g., between an anchor and a suture deployment device, etc.).
the efficacy of an implant (or implants) and its deployed position can be confirmed and monitored at various times during and after the deployment procedure via various techniques, including visualization methods such as fluoroscopy.
ANIMAL EXPERIMENTS Two sixty kilograms adult sheep were sedated, anesthetized and connected to mechanical ventilation. A tracheal tube was inserted and the sheep put on the right side on an operating table. Under sterile conditions the chest was opened under the 5 th rib and the pericardium was opened. A purse-string suture with a tourniquet was put on the left atrial appendage. A device of the type described above was inserted through the purse-string suture and advanced to the apex of the left ventricle. At this location, the anchor was deployed. Four weeks after the procedure, the sheep were taken back to the animal facility, anesthetized, and sacrificed by means of high dose potassium. The hearts were extracted and inspected.
the anchors were found not to have penetrated the left ventricular wall and had remained in the position where they were placed during surgery. At gross inspection the anchors had healed smoothly in normal thin scar tissue and were covered by a thin layer of endothelium. A pull test was performed by pulling in the thread. At a pulling force of 1.6 Kilogram, the anchor tore out the scar tissue with surrounding heart muscle while still being intact inside the chunk of muscle. Thus one could conclude that the healing in into the left ventricular wall was stronger than the muscle itself. Using a third sheep of sixty kilograms, the same surgical procedure was performed. This time the animal was sacrificed immediately and the heart extracted.
the 800 gram fixation force is redundant to what is needed for strength when attaching a chordae tendinae to a papillary muscle and more than sufficient for treating a dilated ventricular wall.

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Health & Medical Sciences (AREA)
Cardiology (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Biomedical Technology (AREA)
Heart & Thoracic Surgery (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Transplantation (AREA)
Oral & Maxillofacial Surgery (AREA)
Vascular Medicine (AREA)
Surgery (AREA)
Molecular Biology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medical Informatics (AREA)
Rheumatology (AREA)
Prostheses (AREA)
Surgical Instruments (AREA)

US12/031,490 2007-02-14 2008-02-14 Suture and method for repairing a heart Abandoned US20080195126A1 (en)

Priority Applications (4)

Application Number	Priority Date	Filing Date	Title
US12/031,490 US20080195126A1 (en)	2007-02-14	2008-02-14	Suture and method for repairing a heart
US13/662,128 US20130110230A1 (en)	2007-02-14	2012-10-26	Suture and method for repairing a heart
US15/232,274 US9572667B2 (en)	2007-02-14	2016-08-09	Suture and method for repairing a heart
US15/402,603 US10154838B2 (en)	2007-02-14	2017-01-10	Suture and method for repairing a heart

Applications Claiming Priority (2)

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US88992107P	2007-02-14	2007-02-14
US12/031,490 US20080195126A1 (en)	2007-02-14	2008-02-14	Suture and method for repairing a heart

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US12/031,490 Abandoned US20080195126A1 (en)	2007-02-14	2008-02-14	Suture and method for repairing a heart
US13/662,128 Abandoned US20130110230A1 (en)	2007-02-14	2012-10-26	Suture and method for repairing a heart
US15/232,274 Active US9572667B2 (en)	2007-02-14	2016-08-09	Suture and method for repairing a heart
US15/402,603 Active 2028-07-19 US10154838B2 (en)	2007-02-14	2017-01-10	Suture and method for repairing a heart

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US13/662,128 Abandoned US20130110230A1 (en)	2007-02-14	2012-10-26	Suture and method for repairing a heart
US15/232,274 Active US9572667B2 (en)	2007-02-14	2016-08-09	Suture and method for repairing a heart
US15/402,603 Active 2028-07-19 US10154838B2 (en)	2007-02-14	2017-01-10	Suture and method for repairing a heart

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US (4)	US20080195126A1 (fr)
EP (2)	EP2114304B1 (fr)
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Cited By (177)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20050004668A1 (en) *	2003-07-02	2005-01-06	Flexcor, Inc.	Annuloplasty rings and methods for repairing cardiac valves
US20090222081A1 (en) *	2008-01-24	2009-09-03	Coherex Medical, Inc.	Methods and apparatus for reducing valve prolapse
US20100023118A1 (en) *	2008-07-24	2010-01-28	Edwards Lifesciences Corporation	Method and apparatus for repairing or replacing chordae tendinae
US20100042147A1 (en) *	2008-08-14	2010-02-18	Edwards Lifesciences Corporation	Method and apparatus for repairing or replacing chordae tendinae
US20100161043A1 (en) *	2008-12-22	2010-06-24	Valtech Cardio, Ltd.	Implantation of repair chords in the heart
US20100280604A1 (en) *	2009-05-04	2010-11-04	Valtech Cardio, Ltd.	Over-wire rotation tool
US20110190879A1 (en) *	2010-02-03	2011-08-04	Edwards Lifesciences Corporation	Devices and Methods for Treating a Heart
US20110264208A1 (en) *	2010-04-27	2011-10-27	Medtronic, Inc.	Prosthetic Heart Valve Devices and Methods of Valve Repair
WO2012040865A1 (fr)	2010-10-01	2012-04-05	Alberto Weber	Appareil médical et procédé de réparation d'une valvule cardiaque
US8241351B2 (en)	2008-12-22	2012-08-14	Valtech Cardio, Ltd.	Adjustable partial annuloplasty ring and mechanism therefor
US20140107769A1 (en) *	2009-03-31	2014-04-17	The Cleveland Clinic Foundation	Pre-sized prosthetic chordae implantation system
US8715342B2 (en)	2009-05-07	2014-05-06	Valtech Cardio, Ltd.	Annuloplasty ring with intra-ring anchoring
US8734467B2 (en)	2009-12-02	2014-05-27	Valtech Cardio, Ltd.	Delivery tool for implantation of spool assembly coupled to a helical anchor
US20140148898A1 (en) *	2005-03-17	2014-05-29	Valtech Cardio Ltd.	Mitral valve treatment techniques
US8858623B2 (en)	2011-11-04	2014-10-14	Valtech Cardio, Ltd.	Implant having multiple rotational assemblies
US8926696B2 (en)	2008-12-22	2015-01-06	Valtech Cardio, Ltd.	Adjustable annuloplasty devices and adjustment mechanisms therefor
US8926695B2 (en)	2006-12-05	2015-01-06	Valtech Cardio, Ltd.	Segmented ring placement
US8940044B2 (en)	2011-06-23	2015-01-27	Valtech Cardio, Ltd.	Closure element for use with an annuloplasty structure
US9011520B2 (en)	2009-10-29	2015-04-21	Valtech Cardio, Ltd.	Tissue anchor for annuloplasty device
US9011530B2 (en)	2008-12-22	2015-04-21	Valtech Cardio, Ltd.	Partially-adjustable annuloplasty structure
US20150157311A1 (en) *	2012-10-16	2015-06-11	Rasiklal Shamji Shah	Laparoscopic device for anchoring an organ to thoracic diaphragm
WO2015103434A1 (fr)	2014-01-03	2015-07-09	Tozzi Luigi P	Appareil et procédé pour remodeler la géométrie d'une valve cardiaque malade
US20150257883A1 (en) *	2014-03-17	2015-09-17	Evalve, Inc.	Mitral valve fixation device removal devices and methods
US9180007B2 (en)	2009-10-29	2015-11-10	Valtech Cardio, Ltd.	Apparatus and method for guide-wire based advancement of an adjustable implant
US9198756B2 (en)	2010-11-18	2015-12-01	Pavilion Medical Innovations, Llc	Tissue restraining devices and methods of use
WO2016008058A1 (fr)	2014-07-17	2016-01-21	Coremedic Ag	Appareil et procédé médicaux pour réparation de valvule cardiaque
US9277994B2 (en)	2008-12-22	2016-03-08	Valtech Cardio, Ltd.	Implantation of repair chords in the heart
US9289295B2 (en)	2010-11-18	2016-03-22	Pavilion Medical Innovations, Llc	Tissue restraining devices and methods of use
US9351830B2 (en)	2006-12-05	2016-05-31	Valtech Cardio, Ltd.	Implant and anchor placement
WO2016126699A1 (fr) *	2015-02-02	2016-08-11	On-X Life Technologies, Inc.	Système de cordage tendineux artificiel à déploiement rapide
US9561104B2 (en)	2009-02-17	2017-02-07	Valtech Cardio, Ltd.	Actively-engageable movement-restriction mechanism for use with an annuloplasty structure
US9610162B2 (en)	2013-12-26	2017-04-04	Valtech Cardio, Ltd.	Implantation of flexible implant
US9724192B2 (en)	2011-11-08	2017-08-08	Valtech Cardio, Ltd.	Controlled steering functionality for implant-delivery tool
US9730793B2 (en)	2012-12-06	2017-08-15	Valtech Cardio, Ltd.	Techniques for guide-wire based advancement of a tool
EP3146904A4 (fr) *	2014-05-20	2018-01-24	Taupnumedical Co., Ltd	Dispositif de protection des tissus pour procédure de cerclage d'une membrane de valvule mitrale
EP3158940A4 (fr) *	2014-06-17	2018-01-24	Taupnumedical Co. Ltd.	Dispositif de protection de tissu pour une chirurgie de régurgitation tricuspidienne
US9883943B2 (en)	2006-12-05	2018-02-06	Valtech Cardio, Ltd.	Implantation of repair devices in the heart
US9949828B2 (en)	2012-10-23	2018-04-24	Valtech Cardio, Ltd.	Controlled steering functionality for implant-delivery tool
US9968452B2 (en)	2009-05-04	2018-05-15	Valtech Cardio, Ltd.	Annuloplasty ring delivery cathethers
US10022224B2 (en)	2012-08-17	2018-07-17	On-X Life Technologies, Inc.	Biological chord repair system and methods
US20180235758A1 (en) *	2015-10-27	2018-08-23	Xeltis, Bv	Medical device using bioabsorbable material
US10098737B2 (en)	2009-10-29	2018-10-16	Valtech Cardio, Ltd.	Tissue anchor for annuloplasty device
JP2018531092A (ja) *	2015-10-21	2018-10-25	コアメディックアーゲーＣｏｒｅｍｅｄｉｃＡｇ	心臓弁の修復用の医療インプラントおよび方法
US10195030B2 (en)	2014-10-14	2019-02-05	Valtech Cardio, Ltd.	Leaflet-restraining techniques
WO2019034081A1 (fr) *	2017-08-17	2019-02-21	杭州德晋医疗科技有限公司	Système d'implantation de cordages tendineux artificiels et appareil d'aide au serrage associé
US10213306B2 (en)	2017-03-31	2019-02-26	Neochord, Inc.	Minimally invasive heart valve repair in a beating heart
US10226342B2 (en)	2016-07-08	2019-03-12	Valtech Cardio, Ltd.	Adjustable annuloplasty device with alternating peaks and troughs
US10231831B2 (en)	2009-12-08	2019-03-19	Cardiovalve Ltd.	Folding ring implant for heart valve
US10299793B2 (en)	2013-10-23	2019-05-28	Valtech Cardio, Ltd.	Anchor magazine
WO2019105073A1 (fr) *	2017-11-28	2019-06-06	杭州德晋医疗科技有限公司	Système d'implantation de cordages tendineux artificiels à deux côtés
EP3505077A1 (fr) *	2014-09-17	2019-07-03	Cardiomech AS	Dispositif de réparation du coeur
US10363138B2 (en)	2016-11-09	2019-07-30	Evalve, Inc.	Devices for adjusting the curvature of cardiac valve structures
WO2019145941A1 (fr) *	2018-01-26	2019-08-01	Valtech Cardio, Ltd.	Techniques pour faciliter la fixation de valve cardiaque et le remplacement de cordon
US10376266B2 (en)	2012-10-23	2019-08-13	Valtech Cardio, Ltd.	Percutaneous tissue anchor techniques
US10390943B2 (en)	2014-03-17	2019-08-27	Evalve, Inc.	Double orifice device for transcatheter mitral valve replacement
US10426616B2 (en)	2016-11-17	2019-10-01	Evalve, Inc.	Cardiac implant delivery system
FR3079409A1 (fr) *	2018-04-03	2019-10-04	Seguin Jacques	Systeme de traitement d'une valve cardiaque, en particulier une valve mitrale ou tricuspide
US10449333B2 (en)	2013-03-14	2019-10-22	Valtech Cardio, Ltd.	Guidewire feeder
WO2019217638A1 (fr) *	2018-05-09	2019-11-14	Neochord, Inc.	Systèmes et procédés de réparation de valvule cardiaque par transcathéter
US10499941B2 (en)	2012-12-14	2019-12-10	Mayo Foundation For Medical Education And Research	Mitral valve repair devices
US10517719B2 (en)	2008-12-22	2019-12-31	Valtech Cardio, Ltd.	Implantation of repair devices in the heart
JP2020503165A (ja) *	2016-12-30	2020-01-30	パイプラインメディカルテクノロジーズ，インコーポレイテッド	新生腱索の経血管的埋め込み方法及び装置
US10548733B2 (en) *	2016-12-30	2020-02-04	Pipeline Medical Technologies, Inc.	Method of transvascular prosthetic chordae tendinae implantation
CN110897763A (zh) *	2018-09-17	2020-03-24	东莞市先健医疗有限公司	医疗器械输送装置
US10639151B2 (en)	2016-07-29	2020-05-05	Cephea Valve Technologies, Inc.	Threaded coil
US10646689B2 (en)	2016-07-29	2020-05-12	Cephea Valve Technologies, Inc.	Mechanical interlock for catheters
US10661052B2 (en)	2016-07-29	2020-05-26	Cephea Valve Technologies, Inc.	Intravascular device delivery sheath
WO2020109582A1 (fr) *	2018-11-29	2020-06-04	Cardiomech As	Dispositif pour réparation cardiaque
US10682232B2 (en)	2013-03-15	2020-06-16	Edwards Lifesciences Corporation	Translation catheters, systems, and methods of use thereof
GB2579433A (en) *	2018-11-29	2020-06-24	Cardiomech As	Device for heart repair
US10695046B2 (en)	2005-07-05	2020-06-30	Edwards Lifesciences Corporation	Tissue anchor and anchoring system
US10702274B2 (en)	2016-05-26	2020-07-07	Edwards Lifesciences Corporation	Method and system for closing left atrial appendage
US10736632B2 (en)	2016-07-06	2020-08-11	Evalve, Inc.	Methods and devices for valve clip excision
US10751182B2 (en)	2015-12-30	2020-08-25	Edwards Lifesciences Corporation	System and method for reshaping right heart
US10765514B2 (en)	2015-04-30	2020-09-08	Valtech Cardio, Ltd.	Annuloplasty technologies
US10792152B2 (en)	2011-06-23	2020-10-06	Valtech Cardio, Ltd.	Closed band for percutaneous annuloplasty
US10828160B2 (en)	2015-12-30	2020-11-10	Edwards Lifesciences Corporation	System and method for reducing tricuspid regurgitation
US10835221B2 (en)	2017-11-02	2020-11-17	Valtech Cardio, Ltd.	Implant-cinching devices and systems
US20200368022A1 (en) *	2011-06-01	2020-11-26	Neochord, Inc.	Minimally Invasive Repair of Heart Valve Leaflets
US10874512B2 (en)	2016-10-05	2020-12-29	Cephea Valve Technologies, Inc.	System and methods for delivering and deploying an artificial heart valve within the mitral annulus
WO2021003375A1 (fr) *	2019-07-03	2021-01-07	Boston Scientific Scimed, Inc.	Dispositifs, systèmes et procédés d'ancrage d'un cordage tendineux artificiel à un muscle papillaire ou à une paroi cardiaque
US10918374B2 (en)	2013-02-26	2021-02-16	Edwards Lifesciences Corporation	Devices and methods for percutaneous tricuspid valve repair
US10918373B2 (en)	2013-08-31	2021-02-16	Edwards Lifesciences Corporation	Devices and methods for locating and implanting tissue anchors at mitral valve commissure
US10925731B2 (en)	2016-12-30	2021-02-23	Pipeline Medical Technologies, Inc.	Method and apparatus for transvascular implantation of neo chordae tendinae
US10925610B2 (en)	2015-03-05	2021-02-23	Edwards Lifesciences Corporation	Devices for treating paravalvular leakage and methods use thereof
WO2021034538A1 (fr) *	2019-08-22	2021-02-25	Edwards Lifesciences Corporation	Accrochage de feuillet de valvule cardiaque
US10933216B2 (en)	2016-08-29	2021-03-02	Cephea Valve Technologies, Inc.	Multilumen catheter
US10974027B2 (en)	2016-07-29	2021-04-13	Cephea Valve Technologies, Inc.	Combination steerable catheter and systems
US20210137679A1 (en) *	2019-11-07	2021-05-13	Primo Medical Group, Inc.	Systems, apparatus and methods to repair operation of a heart valve
US11026791B2 (en)	2018-03-20	2021-06-08	Medtronic Vascular, Inc.	Flexible canopy valve repair systems and methods of use
US11026672B2 (en)	2017-06-19	2021-06-08	Harpoon Medical, Inc.	Method and apparatus for cardiac procedures
CN113017927A (zh) *	2021-03-22	2021-06-25	上海骊霄医疗技术有限公司	一种可捕捉和固定的二尖瓣修复装置
US11045627B2 (en)	2017-04-18	2021-06-29	Edwards Lifesciences Corporation	Catheter system with linear actuation control mechanism
US11045315B2 (en)	2016-08-29	2021-06-29	Cephea Valve Technologies, Inc.	Methods of steering and delivery of intravascular devices
US11071564B2 (en)	2016-10-05	2021-07-27	Evalve, Inc.	Cardiac valve cutting device
US11090155B2 (en) *	2012-07-30	2021-08-17	Tendyne Holdings, Inc.	Delivery systems and methods for transcatheter prosthetic valves
US11103350B2 (en)	2016-06-01	2021-08-31	On-X Life Technologies, Inc.	Pull-through chordae tendineae system
CN113347946A (zh) *	2018-11-29	2021-09-03	卡尔迪欧迈科公司	心脏修复装置
US11109967B2 (en)	2016-08-29	2021-09-07	Cephea Valve Technologies, Inc.	Systems and methods for loading and deploying an intravascular device
US11116633B2 (en)	2016-11-11	2021-09-14	Evalve, Inc.	Opposing disk device for grasping cardiac valve tissue
US11123191B2 (en)	2018-07-12	2021-09-21	Valtech Cardio Ltd.	Annuloplasty systems and locking tools therefor
US11135062B2 (en)	2017-11-20	2021-10-05	Valtech Cardio Ltd.	Cinching of dilated heart muscle
US11147673B2 (en)	2018-05-22	2021-10-19	Boston Scientific Scimed, Inc.	Percutaneous papillary muscle relocation
US11173030B2 (en)	2018-05-09	2021-11-16	Neochord, Inc.	Suture length adjustment for minimally invasive heart valve repair
US11253360B2 (en)	2018-05-09	2022-02-22	Neochord, Inc.	Low profile tissue anchor for minimally invasive heart valve repair
US11259924B2 (en)	2006-12-05	2022-03-01	Valtech Cardio Ltd.	Implantation of repair devices in the heart
CN114206265A (zh) *	2019-04-16	2022-03-18	尼奥绰德有限公司	用于微创心脏瓣膜修复的横向螺旋心脏锚固器
US11285000B2 (en)	2017-02-01	2022-03-29	Tau Pnu Medical Co., Ltd.	Tool for tricuspid regurgitation operation
US11285003B2 (en)	2018-03-20	2022-03-29	Medtronic Vascular, Inc.	Prolapse prevention device and methods of use thereof
US11324495B2 (en)	2016-07-29	2022-05-10	Cephea Valve Technologies, Inc.	Systems and methods for delivering an intravascular device to the mitral annulus
US20220142778A1 (en) *	2019-01-28	2022-05-12	Vesalius Cardiovascular Inc.	Apparatus for use in repairing mitral valves and method of use thereof
CN114502082A (zh) *	2019-09-23	2022-05-13	W.L.戈尔及同仁股份有限公司	用于二尖瓣腱索修复的锚定件
CN114680968A (zh) *	2020-12-31	2022-07-01	深圳市健心医疗科技有限公司	心尖闭合装置
US11395648B2 (en)	2012-09-29	2022-07-26	Edwards Lifesciences Corporation	Plication lock delivery system and method of use thereof
WO2022173780A1 (fr) *	2021-02-09	2022-08-18	Edwards Lifesciences Corporation	Fils haute résistance pour interventions cardiaques
US20220305251A1 (en) *	2018-03-05	2022-09-29	Harmony Development Group, Inc.	Force transducting implant system for the mitigation of atrioventricular pressure gradient loss and the restoration of healthy ventricular geometry
US11478351B2 (en) *	2018-01-22	2022-10-25	Edwards Lifesciences Corporation	Heart shape preserving anchor
US11529233B2 (en)	2016-04-22	2022-12-20	Edwards Lifesciences Corporation	Beating-heart mitral valve chordae replacement
US11590321B2 (en)	2015-06-19	2023-02-28	Evalve, Inc.	Catheter guiding system and methods
US11612389B2 (en)	2018-03-23	2023-03-28	Neochord, Inc.	Device for suture attachment for minimally invasive heart valve repair
US11653910B2 (en)	2010-07-21	2023-05-23	Cardiovalve Ltd.	Helical anchor implantation
US11660190B2 (en)	2007-03-13	2023-05-30	Edwards Lifesciences Corporation	Tissue anchors, systems and methods, and devices
US11660191B2 (en)	2008-03-10	2023-05-30	Edwards Lifesciences Corporation	Method to reduce mitral regurgitation
US11678872B2 (en)	2014-01-03	2023-06-20	University Of Maryland, Baltimore	Method and apparatus for transapical procedures on a mitral valve
US11696828B2 (en)	2016-12-30	2023-07-11	Pipeline Medical Technologies, Inc.	Method and apparatus for mitral valve chord repair
US11724068B2 (en)	2018-11-16	2023-08-15	Cephea Valve Technologies, Inc.	Intravascular delivery system
US11759318B2 (en)	2012-07-28	2023-09-19	Tendyne Holdings, Inc.	Multi-component designs for heart valve retrieval device, sealing structures and stent assembly
US11766331B2 (en)	2020-05-27	2023-09-26	Politecnico Di Milano	Device and assembly to repair a heart valve
US11779458B2 (en)	2016-08-10	2023-10-10	Cardiovalve Ltd.	Prosthetic valve with leaflet connectors
US11779463B2 (en)	2018-01-24	2023-10-10	Edwards Lifesciences Innovation (Israel) Ltd.	Contraction of an annuloplasty structure
US11801135B2 (en)	2015-02-05	2023-10-31	Cardiovalve Ltd.	Techniques for deployment of a prosthetic valve
US11819411B2 (en)	2019-10-29	2023-11-21	Edwards Lifesciences Innovation (Israel) Ltd.	Annuloplasty and tissue anchor technologies
US11844691B2 (en)	2013-01-24	2023-12-19	Cardiovalve Ltd.	Partially-covered prosthetic valves
US11937795B2 (en)	2016-02-16	2024-03-26	Cardiovalve Ltd.	Techniques for providing a replacement valve and transseptal communication
US11969348B2 (en)	2011-12-12	2024-04-30	Edwards Lifesciences Corporation	Cardiac valve replacement
US12023247B2 (en)	2020-05-20	2024-07-02	Edwards Lifesciences Corporation	Reducing the diameter of a cardiac valve annulus with independent control over each of the anchors that are launched into the annulus
US12029646B2 (en)	2017-08-03	2024-07-09	Cardiovalve Ltd.	Prosthetic heart valve
US12048448B2 (en)	2020-05-06	2024-07-30	Evalve, Inc.	Leaflet grasping and cutting device
US12053380B2 (en)	2014-07-30	2024-08-06	Cardiovalve Ltd.	Anchoring of a prosthetic valve
US12053379B2 (en)	2016-08-01	2024-08-06	Cardiovalve Ltd.	Minimally-invasive delivery systems
US12090048B2 (en)	2017-08-03	2024-09-17	Cardiovalve Ltd.	Prosthetic heart valve
US12102531B2 (en)	2018-10-22	2024-10-01	Evalve, Inc.	Tissue cutting systems, devices and methods
US20240325730A1 (en) *	2010-12-29	2024-10-03	Medtronic, Inc.	Implantable medical device fixation
US12128203B2 (en)	2016-07-07	2024-10-29	Primo Medical Group, Inc.	Septum for access port
US12138165B2 (en)	2011-06-23	2024-11-12	Edwards Lifesciences Innovation (Israel) Ltd.	Annuloplasty implants
US12137897B2 (en)	2018-09-07	2024-11-12	Neochord, Inc.	Device for suture attachment for minimally invasive heart valve repair
US20240407914A1 (en) *	2009-12-04	2024-12-12	Edwards Lifesciences Corporation	Prosthetic valve having a multi-part frame
US12171662B1 (en)	2023-10-26	2024-12-24	Approxima Srl	Heart chamber reshaping and valve repair system
US12171486B2 (en)	2020-05-06	2024-12-24	Evalve, Inc.	Devices and methods for clip separation
US12171485B2 (en)	2020-05-06	2024-12-24	Evalve, Inc.	Systems and methods for leaflet cutting using a hook catheter
US12178444B2 (en)	2020-05-06	2024-12-31	Evalve, Inc.	Clip removal systems and methods
US20250000645A1 (en) *	2008-05-01	2025-01-02	Edwards Lifesciences Corporation	Method of implanting a prosthetic heart valve assembly
US12201525B2 (en)	2015-10-02	2025-01-21	Harpoon Medical, Inc.	Tissue anchor deployment
US12208007B2 (en)	2020-01-16	2025-01-28	Neochord, Inc.	Helical cardiac anchors for minimally invasive heart valve repair
US12208006B2 (en)	2019-09-25	2025-01-28	Edwards Lifesciences Corporation	Constricting a cardiac valve annulus using a cord that has a loop portion and a single second portion
US12226096B2 (en)	2019-05-29	2025-02-18	Edwards Lifesciences Innovation (Israel) Ltd.	Tissue anchor handling systems and methods
US12290439B2 (en)	2017-07-24	2025-05-06	Emory University	Cardiac valve leaflet enhancer devices and systems
US12318296B2 (en)	2015-12-30	2025-06-03	Pipeline Medical Technologies, Inc.	Mitral leaflet tethering
US12350155B2 (en)	2020-06-17	2025-07-08	Pipeline Medical Technologies, Inc.	Method and apparatus for mitral valve chord repair
US12357459B2 (en)	2020-12-03	2025-07-15	Cardiovalve Ltd.	Transluminal delivery system
US12364606B2 (en)	2019-07-23	2025-07-22	Edwards Lifesciences Innovation (Israel) Ltd.	Fluoroscopic visualization of heart valve anatomy
US12369905B2 (en)	2020-09-10	2025-07-29	Edwards Lifesciences Corporation	Closing tissue openings
US12396718B2 (en)	2020-06-19	2025-08-26	Edwards Lifesciences Corporation	Self-stopping tissue anchors
US12396855B1 (en)	2024-07-25	2025-08-26	Nyra Medical, Inc.	Systems, devices, and methods for reducing heart valve regurgitation
US12414811B2 (en)	2020-05-06	2025-09-16	Evalve, Inc.	Devices and methods for leaflet cutting
US12419631B2 (en)	2020-04-22	2025-09-23	Edwards Lifesciences Corporation	Controlled suture tensioning
US12419749B2 (en)	2019-08-30	2025-09-23	Edwards Lifesciences Innovation (Israel) Ltd.	Anchor channel tip
US12433749B2 (en)	2023-08-25	2025-10-07	Emory University	Systems, devices, and methods for reducing heart valve regurgitation
US12440206B2 (en)	2019-02-12	2025-10-14	Edwards Lifesciences Corporation	Controlled tissue anchor spacing
US12440648B2 (en)	2019-08-28	2025-10-14	Edwards Lifesciences Innovation (Israel) Ltd.	Low-profile steerable catheter
US12440204B2 (en)	2022-12-06	2025-10-14	Boston Scientific Scimed, Inc.	Medical device for cutting a suture during a minimally invasive procedure
US12458498B2 (en)	2021-02-10	2025-11-04	Edwards Lifesciences Corporation	Implanting grafts to valve leaflets for cardiac procedures
US12458493B2 (en)	2017-09-19	2025-11-04	Cardiovalve Ltd.	Prosthetic heart valve and delivery systems and methods
US12472062B2 (en)	2016-12-30	2025-11-18	Pipeline Medical Technologies, Inc.	Method and apparatus for mitral valve chord repair
US12485010B2 (en)	2009-05-07	2025-12-02	Edwards Lifesciences Innovation (Israel) Ltd.	Multiple anchor delivery tool
US12485009B2 (en)	2017-12-20	2025-12-02	W. L. Gore & Associates, Inc.	Artificial chordae tendineae repair devices and delivery thereof
US12502170B2 (en)	2023-06-23	2025-12-23	Edwards Lifesciences Corporation	Trigger-based tissue anchor deployment

Families Citing this family (96)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP5186366B2 (ja)	2005-06-20	2013-04-17	スーチュラ，インコーポレイテッド	縫合糸に結び目を作る装置
US20080195126A1 (en) *	2007-02-14	2008-08-14	Jan Otto Solem	Suture and method for repairing a heart
JP5411125B2 (ja)	2007-03-29	2014-02-12	ノーブルズメディカルテクノロジーズ、インコーポレイテッド	卵円孔開存を閉鎖するための縫合装置、及びシステム
DE102007043830A1 (de)	2007-09-13	2009-04-02	Lozonschi, Lucian, Madison	Herzklappenstent
WO2010070649A1 (fr)	2008-12-21	2010-06-24	Mor Research Applications Ltd.	Corps allongé pour son déploiement dans un sinus coronaire
EP2367505B1 (fr)	2008-09-29	2020-08-12	Edwards Lifesciences CardiAQ LLC	Valvule cardiaque
EP2845569A1 (fr)	2008-10-01	2015-03-11	Cardiaq Valve Technologies, Inc.	Système d'administration pour implant vasculaire
WO2010121076A2 (fr)	2009-04-15	2010-10-21	Cardiaq Valve Technologies, Inc.	Implant vasculaire et système d'introduction
EP3838223B1 (fr)	2009-12-08	2025-08-20	Avalon Medical Ltd.	Dispositif et système de remplacement de valvule mitrale par transcathéter
US9307980B2 (en)	2010-01-22	2016-04-12	4Tech Inc.	Tricuspid valve repair using tension
US8475525B2 (en)	2010-01-22	2013-07-02	4Tech Inc.	Tricuspid valve repair using tension
US10058323B2 (en)	2010-01-22	2018-08-28	4 Tech Inc.	Tricuspid valve repair using tension
US8579964B2 (en)	2010-05-05	2013-11-12	Neovasc Inc.	Transcatheter mitral valve prosthesis
US9554897B2 (en)	2011-04-28	2017-01-31	Neovasc Tiara Inc.	Methods and apparatus for engaging a valve prosthesis with tissue
US9308087B2 (en)	2011-04-28	2016-04-12	Neovasc Tiara Inc.	Sequentially deployed transcatheter mitral valve prosthesis
WO2013028387A2 (fr)	2011-08-11	2013-02-28	Tendyne Holdings, Inc.	Améliorations apportées à des valves prothétiques et inventions associées
US9827092B2 (en)	2011-12-16	2017-11-28	Tendyne Holdings, Inc.	Tethers for prosthetic mitral valve
CA2900930A1 (fr)	2012-02-13	2013-08-22	Mitraspan, Inc.	Procede et appareil de reparation d'une valvule mitrale
US10076414B2 (en)	2012-02-13	2018-09-18	Mitraspan, Inc.	Method and apparatus for repairing a mitral valve
US9345573B2 (en)	2012-05-30	2016-05-24	Neovasc Tiara Inc.	Methods and apparatus for loading a prosthesis onto a delivery system
EP2943132B1 (fr)	2013-01-09	2018-03-28	4Tech Inc.	Organes d'ancrage de tissu mou
US10583002B2 (en)	2013-03-11	2020-03-10	Neovasc Tiara Inc.	Prosthetic valve with anti-pivoting mechanism
CN105208978B (zh)	2013-03-14	2016-12-07	4科技有限公司	具有系绳接口的支架
US9681951B2 (en)	2013-03-14	2017-06-20	Edwards Lifesciences Cardiaq Llc	Prosthesis with outer skirt and anchors
US11224510B2 (en)	2013-04-02	2022-01-18	Tendyne Holdings, Inc.	Prosthetic heart valve and systems and methods for delivering the same
US10463489B2 (en)	2013-04-02	2019-11-05	Tendyne Holdings, Inc.	Prosthetic heart valve and systems and methods for delivering the same
US9572665B2 (en)	2013-04-04	2017-02-21	Neovasc Tiara Inc.	Methods and apparatus for delivering a prosthetic valve to a beating heart
US10478293B2 (en)	2013-04-04	2019-11-19	Tendyne Holdings, Inc.	Retrieval and repositioning system for prosthetic heart valve
US9610159B2 (en)	2013-05-30	2017-04-04	Tendyne Holdings, Inc.	Structural members for prosthetic mitral valves
CA2919221C (fr) *	2013-06-17	2021-09-21	Alan HELDMAN	Prothese de valvule cardiaque avec element de liaison et procedes d'implantation associe
CA2914856C (fr)	2013-06-25	2021-03-09	Chad Perrin	Caracteristiques de gestion de thrombus et de conformite structurelle pour valvules cardiaques prothetiques
EP3473189B1 (fr)	2013-07-02	2024-11-20	Med-venture Investments, LLC	Dispositifs de suture d'une structure anatomique
JP6465883B2 (ja)	2013-08-01	2019-02-06	テンダインホールディングス，インコーポレイテッド	心外膜アンカーデバイス及び方法
WO2015058039A1 (fr)	2013-10-17	2015-04-23	Robert Vidlund	Appareil et procedes d'alignement et de deploiement de dispositifs intracardiaques
AU2014342935B2 (en)	2013-10-28	2019-05-16	Tendyne Holdings, Inc.	Prosthetic heart valve and systems and methods for delivering the same
US9526611B2 (en)	2013-10-29	2016-12-27	Tendyne Holdings, Inc.	Apparatus and methods for delivery of transcatheter prosthetic valves
US10052095B2 (en)	2013-10-30	2018-08-21	4Tech Inc.	Multiple anchoring-point tension system
US10022114B2 (en)	2013-10-30	2018-07-17	4Tech Inc.	Percutaneous tether locking
EP3079602B1 (fr)	2013-12-06	2020-01-22	Med-venture Investments, LLC	Appareils de suture
WO2015120122A2 (fr)	2014-02-05	2015-08-13	Robert Vidlund	Appareil et procédés pour la mise en place d'une valve mitrale prothétique par l'artère fémorale
US9986993B2 (en)	2014-02-11	2018-06-05	Tendyne Holdings, Inc.	Adjustable tether and epicardial pad system for prosthetic heart valve
CA2937566C (fr)	2014-03-10	2023-09-05	Tendyne Holdings, Inc.	Dispositifs et procedes de positionnement et de controle de charge de cable d'attache pour valvule mitrale prothetique
US9801720B2 (en) *	2014-06-19	2017-10-31	4Tech Inc.	Cardiac tissue cinching
JP6717820B2 (ja)	2014-12-02	2020-07-08	４テックインコーポレイテッド	偏心組織アンカー
CA2972966C (fr)	2015-01-07	2023-01-10	Tendyne Holdings, Inc.	Protheses de valvules mitrales et appareil et procedes de mise en place associe
ES2877699T3 (es)	2015-02-05	2021-11-17	Tendyne Holdings Inc	Válvula cardiaca protésica con ligación y almohadilla epicárdica expandible
WO2016144391A1 (fr)	2015-03-11	2016-09-15	Mvrx, Inc.	Dispositifs, systèmes et procédés de refaçonnage d'anneau de valvule cardiaque
JP6694948B2 (ja)	2015-04-16	2020-05-20	テンダインホールディングス，インコーポレイテッド	経カテーテル人工弁の送達、再配置及び回収のための装置及び方法
US10327894B2 (en)	2015-09-18	2019-06-25	Tendyne Holdings, Inc.	Methods for delivery of prosthetic mitral valves
ES2777609T3 (es)	2015-12-03	2020-08-05	Tendyne Holdings Inc	Características del marco para válvulas mitrales protésicas
WO2017100927A1 (fr)	2015-12-15	2017-06-22	Neovasc Tiara Inc.	Système d'administration trans-septale
WO2017117109A1 (fr)	2015-12-28	2017-07-06	Tendyne Holdings, Inc.	Fermetures de poche auriculaire pour valvules cardiaques prothétiques
US10441274B2 (en) *	2016-01-13	2019-10-15	St. Jude Medical, Cardiology Division, Inc.	Suture clips and methods of deploying same
CN108882981B (zh)	2016-01-29	2021-08-10	内奥瓦斯克迪亚拉公司	用于防止流出阻塞的假体瓣膜
EP3448317B1 (fr)	2016-04-25	2025-12-03	Valfix Medical Ltd.	Réparation et remplacement de valve percutanée
US10470877B2 (en)	2016-05-03	2019-11-12	Tendyne Holdings, Inc.	Apparatus and methods for anterior valve leaflet management
EP3468480B1 (fr)	2016-06-13	2023-01-11	Tendyne Holdings, Inc.	Administration séquentielle de valvule mitrale prothétique en deux parties
CN109640887B (zh)	2016-06-30	2021-03-16	坦迪尼控股股份有限公司	假体心脏瓣膜及用于输送其的装置和方法
EP3484411A1 (fr)	2016-07-12	2019-05-22	Tendyne Holdings, Inc.	Appareil et procédés de récupération transseptale de valvules cardiaques prothétiques
CN109996581B (zh)	2016-11-21	2021-10-15	内奥瓦斯克迪亚拉公司	用于快速收回经导管心脏瓣膜递送系统的方法和系统
WO2018178901A2 (fr)	2017-03-28	2018-10-04	Cardiac Success Ltd.	Procédé permettant d'améliorer le fonctionnement cardiaque
US11318018B2 (en)	2017-03-28	2022-05-03	Cardiac Success Ltd.	Method of improving cardiac function
EP3641663B1 (fr)	2017-06-19	2022-03-02	Heartstitch, Inc.	Systèmes et procédés de suture destinés à suturer un tissu corporel
CN111050702B (zh)	2017-07-13	2022-07-05	坦迪尼控股股份有限公司	人工心脏瓣膜及用于递送人工心脏瓣膜的设备和方法
CN107569301B (zh)	2017-07-31	2023-10-31	杭州德晋医疗科技有限公司	人工腱索及其人工腱索植入系统
US10898180B2 (en)	2017-07-31	2021-01-26	Hangzhou Valgen Medtech Co., Ltd.	Heart valve repair method
CA3073834A1 (fr)	2017-08-25	2019-02-28	Neovasc Tiara Inc.	Prothese de valvule mitrale transcatheter a deploiement sequentiel
US11191639B2 (en)	2017-08-28	2021-12-07	Tendyne Holdings, Inc.	Prosthetic heart valves with tether coupling features
US11591554B2 (en)	2017-09-11	2023-02-28	Heartstitch, Inc.	Methods and devices for papillary suturing
EP3681439B1 (fr)	2017-09-12	2021-07-28	Boston Scientific Scimed, Inc.	Relocalisation percutanée de muscle papillaire
US11464638B2 (en)	2017-10-23	2022-10-11	Cardiac Success Ltd	Adjustable self-locking papillary muscle band
CA3079785A1 (fr)	2017-10-23	2019-05-02	Cardiac Success Ltd.	Bande de muscles papillaires a auto-verrouillage reglable
ES3039962T3 (en) *	2018-03-12	2025-10-28	Pipeline Medical Tech Inc	Apparatus for mitral valve chord repair
US11737877B2 (en)	2018-06-08	2023-08-29	Hangzhou Valgen Medtech Co., Ltd.	Adjustable heart valve repair system
CN108814678B (zh) *	2018-07-06	2020-12-01	李庆臣	用于心脏外科手术中的心尖探查装置
AU2019374743B2 (en)	2018-11-08	2022-03-03	Neovasc Tiara Inc.	Ventricular deployment of a transcatheter mitral valve prosthesis
EP3886766A1 (fr) *	2018-11-27	2021-10-06	Boston Scientific Scimed Inc.	Systèmes et procédés de traitement de valvules cardiaques régurgitantes
GB2579387B (en) *	2018-11-29	2021-01-20	Cardiomech As	Device for heart repair
CN113727674B (zh) *	2019-01-14	2025-05-27	瓦尔菲克斯医疗有限公司	经皮瓣膜植入物的锚定件和锁定件
CA3132873C (fr)	2019-03-08	2024-07-02	Neovasc Tiara Inc	Systeme de pose de prothese recuperable
WO2020206012A1 (fr)	2019-04-01	2020-10-08	Neovasc Tiara Inc.	Valve prothétique déployable de manière contrôlable
CN113924065A (zh)	2019-04-10	2022-01-11	内奥瓦斯克迪亚拉公司	具有自然血流的假体瓣膜
US11779742B2 (en)	2019-05-20	2023-10-10	Neovasc Tiara Inc.	Introducer with hemostasis mechanism
EP3986332A4 (fr)	2019-06-20	2023-07-19	Neovasc Tiara Inc.	Valve mitrale prothétique à profil bas
WO2021072193A1 (fr)	2019-10-11	2021-04-15	Opus Medical Therapies, LLC	Dispositifs d'implantation de cordages par transcathéter et procédés d'implantation
EP3831343B1 (fr)	2019-12-05	2024-01-31	Tendyne Holdings, Inc.	Ancrage tressé pour valvule mitrale
US11648114B2 (en)	2019-12-20	2023-05-16	Tendyne Holdings, Inc.	Distally loaded sheath and loading funnel
WO2021135347A1 (fr) *	2019-12-31	2021-07-08	杭州德晋医疗科技有限公司	Dispositif de distribution d'ancrage et appareil d'implant de tendon artificiel
US11951002B2 (en)	2020-03-30	2024-04-09	Tendyne Holdings, Inc.	Apparatus and methods for valve and tether fixation
GB202008286D0 (en)	2020-06-02	2020-07-15	Cardiomech As	Device for heart repair
EP4199860A1 (fr)	2020-08-19	2023-06-28	Tendyne Holdings, Inc.	Tampon apical entièrement transseptal doté d'une poulie pour la mise sous tension
GB2601146B (en)	2020-11-19	2023-02-22	Cardiomech As	Device for heart repair
CN113303861B (zh) *	2021-05-28	2022-04-26	中国计量大学	血管结扎装置
KR20240156617A (ko)	2022-03-03	2024-10-30	카디오멕 에이에스	심장 복구를 위한 연질 조직 앵커 시스템
GB2634009A (en)	2023-06-08	2025-04-02	Cardiomech As	Device for heart repair
US20250302464A1 (en) *	2024-04-02	2025-10-02	inQB8 Medical Technologies, LLC	Systems for percutaneous ventriculoplasty using ventricular anchors

Citations (29)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3394704A (en) *	1965-10-20	1968-07-30	Torrington Co	Surgical needle with bonded suture
US6136010A (en) *	1999-03-04	2000-10-24	Perclose, Inc.	Articulating suturing device and method
US6165183A (en) *	1998-07-15	2000-12-26	St. Jude Medical, Inc.	Mitral and tricuspid valve repair
US6210432B1 (en) *	1999-06-29	2001-04-03	Jan Otto Solem	Device and method for treatment of mitral insufficiency
US6332863B1 (en) *	1997-01-02	2001-12-25	Myocor, Inc.	Heart wall tension reduction kit
US6537314B2 (en) *	2000-01-31	2003-03-25	Ev3 Santa Rosa, Inc.	Percutaneous mitral annuloplasty and cardiac reinforcement
US20030069628A1 (en) *	2001-09-07	2003-04-10	Solem Jan Otto	Apparatus and a method for delivery of a self-expanding medical device
US20030069636A1 (en) *	1999-06-30	2003-04-10	Solem Jan Otto	Method for treatment of mitral insufficiency
US6626930B1 (en) *	1999-10-21	2003-09-30	Edwards Lifesciences Corporation	Minimally invasive mitral valve repair method and apparatus
US20050177228A1 (en) *	2003-12-16	2005-08-11	Solem Jan O.	Device for changing the shape of the mitral annulus
US20050228422A1 (en) *	2002-11-26	2005-10-13	Ample Medical, Inc.	Devices, systems, and methods for reshaping a heart valve annulus, including the use of magnetic tools
US20060004248A1 (en) *	2004-06-30	2006-01-05	Ethicon Incorporated	Magnetic capture and placement for cardiac assist device
US6997951B2 (en) *	1999-06-30	2006-02-14	Edwards Lifesciences Ag	Method and device for treatment of mitral insufficiency
US7011669B2 (en) *	2000-08-11	2006-03-14	Edwards Lifesciences Corporation	Device and method for treatment of atrioventricular regurgitation
US20060058871A1 (en) *	2004-09-14	2006-03-16	Edwards Lifesciences, Ag	Device and method for treatment of heart valve regurgitation
US7083628B2 (en) *	2002-09-03	2006-08-01	Edwards Lifesciences Corporation	Single catheter mitral valve repair device and method for use
US7094244B2 (en) *	2002-03-26	2006-08-22	Edwards Lifesciences Corporation	Sequential heart valve leaflet repair device and method of use
US20060207607A1 (en) *	2005-02-08	2006-09-21	Mark Hirotsuka	System and method for percutaneous palate remodeling
US20060241745A1 (en) *	2005-04-21	2006-10-26	Solem Jan O	Blood flow controlling apparatus
US20070061010A1 (en) *	2005-09-09	2007-03-15	Hauser David L	Device and method for reshaping mitral valve annulus
US7192443B2 (en) *	2002-01-11	2007-03-20	Edwards Lifesciences Ag	Delayed memory device
US20070073391A1 (en) *	2005-09-28	2007-03-29	Henry Bourang	System and method for delivering a mitral valve repair device
US20070270943A1 (en) *	2006-05-18	2007-11-22	Jan Otto Solem	Device and method for improving heart valve function
US20070282429A1 (en) *	2006-06-01	2007-12-06	Hauser David L	Prosthetic insert for improving heart valve function
US7381210B2 (en) *	2003-03-14	2008-06-03	Edwards Lifesciences Corporation	Mitral valve repair system and method for use
US7431692B2 (en) *	2006-03-09	2008-10-07	Edwards Lifesciences Corporation	Apparatus, system, and method for applying and adjusting a tensioning element to a hollow body organ
US20090054724A1 (en) *	2007-08-22	2009-02-26	Hauser David L	Implantable device for treatment of ventricular dilation
US7500989B2 (en) *	2005-06-03	2009-03-10	Edwards Lifesciences Corp.	Devices and methods for percutaneous repair of the mitral valve via the coronary sinus
US7507252B2 (en) *	2000-01-31	2009-03-24	Edwards Lifesciences Ag	Adjustable transluminal annuloplasty system

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6616684B1 (en) *	2000-10-06	2003-09-09	Myocor, Inc.	Endovascular splinting devices and methods
US20050177180A1 (en)	2001-11-28	2005-08-11	Aptus Endosystems, Inc.	Devices, systems, and methods for supporting tissue and/or structures within a hollow body organ
US20030120341A1 (en) *	2001-12-21	2003-06-26	Hani Shennib	Devices and methods of repairing cardiac valves
US7316706B2 (en)	2003-06-20	2008-01-08	Medtronic Vascular, Inc.	Tensioning device, system, and method for treating mitral valve regurgitation
DE602004007630T2 (de) *	2004-05-25	2008-06-05	William Cook Europe Aps	Stent und Stentbeseitigungsvorrichtung
WO2006039223A2 (fr) *	2004-09-30	2006-04-13	Usgi Medical Inc.	Ensemble d'aiguille pour manipulation de tissus
US20060079736A1 (en) *	2004-10-13	2006-04-13	Sing-Fatt Chin	Method and device for percutaneous left ventricular reconstruction
EP1865887A1 (fr) *	2005-03-25	2007-12-19	Ample Medical, Inc.	Dispositif, systemes et procedes pour retablir la forme d'un anneau de valvule cardiaque
US20070078297A1 (en) *	2005-08-31	2007-04-05	Medtronic Vascular, Inc.	Device for Treating Mitral Valve Regurgitation
US7632308B2 (en) *	2005-11-23	2009-12-15	Didier Loulmet	Methods, devices, and kits for treating mitral valve prolapse
US20080195126A1 (en) *	2007-02-14	2008-08-14	Jan Otto Solem	Suture and method for repairing a heart
WO2010070649A1 (fr) *	2008-12-21	2010-06-24	Mor Research Applications Ltd.	Corps allongé pour son déploiement dans un sinus coronaire

2008
- 2008-02-14 US US12/031,490 patent/US20080195126A1/en not_active Abandoned
- 2008-02-14 EP EP08729902.0A patent/EP2114304B1/fr active Active
- 2008-02-14 EP EP17189396.9A patent/EP3345572A1/fr active Pending
- 2008-02-14 WO PCT/US2008/054007 patent/WO2008101113A1/fr not_active Ceased
2012
- 2012-10-26 US US13/662,128 patent/US20130110230A1/en not_active Abandoned
2016
- 2016-08-09 US US15/232,274 patent/US9572667B2/en active Active
2017
- 2017-01-10 US US15/402,603 patent/US10154838B2/en active Active

Patent Citations (34)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3394704A (en) *	1965-10-20	1968-07-30	Torrington Co	Surgical needle with bonded suture
US6332863B1 (en) *	1997-01-02	2001-12-25	Myocor, Inc.	Heart wall tension reduction kit
US6165183A (en) *	1998-07-15	2000-12-26	St. Jude Medical, Inc.	Mitral and tricuspid valve repair
US6136010A (en) *	1999-03-04	2000-10-24	Perclose, Inc.	Articulating suturing device and method
US20050043792A1 (en) *	1999-06-29	2005-02-24	Edwards Lifesciences Ag	Device and method for treatment of mitral insufficiency
US6210432B1 (en) *	1999-06-29	2001-04-03	Jan Otto Solem	Device and method for treatment of mitral insufficiency
US7044967B1 (en) *	1999-06-29	2006-05-16	Edwards Lifesciences Ag	Device and method for treatment of mitral insufficiency
US7192442B2 (en) *	1999-06-30	2007-03-20	Edwards Lifesciences Ag	Method and device for treatment of mitral insufficiency
US20040102840A1 (en) *	1999-06-30	2004-05-27	Solem Jan Otto	Method and device for treatment of mitral insufficiency
US20030069636A1 (en) *	1999-06-30	2003-04-10	Solem Jan Otto	Method for treatment of mitral insufficiency
US6997951B2 (en) *	1999-06-30	2006-02-14	Edwards Lifesciences Ag	Method and device for treatment of mitral insufficiency
US20060116756A1 (en) *	1999-06-30	2006-06-01	Solem Jan O	Method and device for treatment of mitral insufficiency
US6626930B1 (en) *	1999-10-21	2003-09-30	Edwards Lifesciences Corporation	Minimally invasive mitral valve repair method and apparatus
US7507252B2 (en) *	2000-01-31	2009-03-24	Edwards Lifesciences Ag	Adjustable transluminal annuloplasty system
US6537314B2 (en) *	2000-01-31	2003-03-25	Ev3 Santa Rosa, Inc.	Percutaneous mitral annuloplasty and cardiac reinforcement
US7011669B2 (en) *	2000-08-11	2006-03-14	Edwards Lifesciences Corporation	Device and method for treatment of atrioventricular regurgitation
US20030069628A1 (en) *	2001-09-07	2003-04-10	Solem Jan Otto	Apparatus and a method for delivery of a self-expanding medical device
US7192443B2 (en) *	2002-01-11	2007-03-20	Edwards Lifesciences Ag	Delayed memory device
US7094244B2 (en) *	2002-03-26	2006-08-22	Edwards Lifesciences Corporation	Sequential heart valve leaflet repair device and method of use
US7083628B2 (en) *	2002-09-03	2006-08-01	Edwards Lifesciences Corporation	Single catheter mitral valve repair device and method for use
US20050228422A1 (en) *	2002-11-26	2005-10-13	Ample Medical, Inc.	Devices, systems, and methods for reshaping a heart valve annulus, including the use of magnetic tools
US7381210B2 (en) *	2003-03-14	2008-06-03	Edwards Lifesciences Corporation	Mitral valve repair system and method for use
US20050177228A1 (en) *	2003-12-16	2005-08-11	Solem Jan O.	Device for changing the shape of the mitral annulus
US20060004248A1 (en) *	2004-06-30	2006-01-05	Ethicon Incorporated	Magnetic capture and placement for cardiac assist device
US20060058871A1 (en) *	2004-09-14	2006-03-16	Edwards Lifesciences, Ag	Device and method for treatment of heart valve regurgitation
US20060207607A1 (en) *	2005-02-08	2006-09-21	Mark Hirotsuka	System and method for percutaneous palate remodeling
US20060241745A1 (en) *	2005-04-21	2006-10-26	Solem Jan O	Blood flow controlling apparatus
US7500989B2 (en) *	2005-06-03	2009-03-10	Edwards Lifesciences Corp.	Devices and methods for percutaneous repair of the mitral valve via the coronary sinus
US20070061010A1 (en) *	2005-09-09	2007-03-15	Hauser David L	Device and method for reshaping mitral valve annulus
US20070073391A1 (en) *	2005-09-28	2007-03-29	Henry Bourang	System and method for delivering a mitral valve repair device
US7431692B2 (en) *	2006-03-09	2008-10-07	Edwards Lifesciences Corporation	Apparatus, system, and method for applying and adjusting a tensioning element to a hollow body organ
US20070270943A1 (en) *	2006-05-18	2007-11-22	Jan Otto Solem	Device and method for improving heart valve function
US20070282429A1 (en) *	2006-06-01	2007-12-06	Hauser David L	Prosthetic insert for improving heart valve function
US20090054724A1 (en) *	2007-08-22	2009-02-26	Hauser David L	Implantable device for treatment of ventricular dilation

Cited By (363)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US8052751B2 (en)	2003-07-02	2011-11-08	Flexcor, Inc.	Annuloplasty rings for repairing cardiac valves
US20050004668A1 (en) *	2003-07-02	2005-01-06	Flexcor, Inc.	Annuloplasty rings and methods for repairing cardiac valves
US20140148898A1 (en) *	2005-03-17	2014-05-29	Valtech Cardio Ltd.	Mitral valve treatment techniques
US11497605B2 (en)	2005-03-17	2022-11-15	Valtech Cardio Ltd.	Mitral valve treatment techniques
US9526613B2 (en) *	2005-03-17	2016-12-27	Valtech Cardio Ltd.	Mitral valve treatment techniques
US10561498B2 (en)	2005-03-17	2020-02-18	Valtech Cardio, Ltd.	Mitral valve treatment techniques
US10695046B2 (en)	2005-07-05	2020-06-30	Edwards Lifesciences Corporation	Tissue anchor and anchoring system
US9351830B2 (en)	2006-12-05	2016-05-31	Valtech Cardio, Ltd.	Implant and anchor placement
US10363137B2 (en)	2006-12-05	2019-07-30	Valtech Cardio, Ltd.	Implantation of repair devices in the heart
US8926695B2 (en)	2006-12-05	2015-01-06	Valtech Cardio, Ltd.	Segmented ring placement
US11259924B2 (en)	2006-12-05	2022-03-01	Valtech Cardio Ltd.	Implantation of repair devices in the heart
US9872769B2 (en)	2006-12-05	2018-01-23	Valtech Cardio, Ltd.	Implantation of repair devices in the heart
US9883943B2 (en)	2006-12-05	2018-02-06	Valtech Cardio, Ltd.	Implantation of repair devices in the heart
US9974653B2 (en)	2006-12-05	2018-05-22	Valtech Cardio, Ltd.	Implantation of repair devices in the heart
US10357366B2 (en)	2006-12-05	2019-07-23	Valtech Cardio, Ltd.	Implantation of repair devices in the heart
US11344414B2 (en)	2006-12-05	2022-05-31	Valtech Cardio Ltd.	Implantation of repair devices in the heart
US11660190B2 (en)	2007-03-13	2023-05-30	Edwards Lifesciences Corporation	Tissue anchors, systems and methods, and devices
US20090222081A1 (en) *	2008-01-24	2009-09-03	Coherex Medical, Inc.	Methods and apparatus for reducing valve prolapse
US11660191B2 (en)	2008-03-10	2023-05-30	Edwards Lifesciences Corporation	Method to reduce mitral regurgitation
US20250000645A1 (en) *	2008-05-01	2025-01-02	Edwards Lifesciences Corporation	Method of implanting a prosthetic heart valve assembly
US12376961B2 (en) *	2008-05-01	2025-08-05	Edwards Lifesciences Corporation	Method of implanting a prosthetic heart valve assembly
US20100023118A1 (en) *	2008-07-24	2010-01-28	Edwards Lifesciences Corporation	Method and apparatus for repairing or replacing chordae tendinae
US8778016B2 (en) *	2008-08-14	2014-07-15	Edwards Lifesciences Corporation	Method and apparatus for repairing or replacing chordae tendinae
US20100042147A1 (en) *	2008-08-14	2010-02-18	Edwards Lifesciences Corporation	Method and apparatus for repairing or replacing chordae tendinae
US8252050B2 (en) *	2008-12-22	2012-08-28	Valtech Cardio Ltd.	Implantation of repair chords in the heart
US11116634B2 (en)	2008-12-22	2021-09-14	Valtech Cardio Ltd.	Annuloplasty implants
US9011530B2 (en)	2008-12-22	2015-04-21	Valtech Cardio, Ltd.	Partially-adjustable annuloplasty structure
US12138168B2 (en)	2008-12-22	2024-11-12	Edwards Lifesciences Innovation (Israel) Ltd.	Adjustable annuloplasty devices and adjustment mechanisms therefor
US10470882B2 (en)	2008-12-22	2019-11-12	Valtech Cardio, Ltd.	Closure element for use with annuloplasty structure
US8808368B2 (en)	2008-12-22	2014-08-19	Valtech Cardio, Ltd.	Implantation of repair chords in the heart
US8241351B2 (en)	2008-12-22	2012-08-14	Valtech Cardio, Ltd.	Adjustable partial annuloplasty ring and mechanism therefor
US10856986B2 (en)	2008-12-22	2020-12-08	Valtech Cardio, Ltd.	Adjustable annuloplasty devices and adjustment mechanisms therefor
US10517719B2 (en)	2008-12-22	2019-12-31	Valtech Cardio, Ltd.	Implantation of repair devices in the heart
US9713530B2 (en)	2008-12-22	2017-07-25	Valtech Cardio, Ltd.	Adjustable annuloplasty devices and adjustment mechanisms therefor
US9662209B2 (en)	2008-12-22	2017-05-30	Valtech Cardio, Ltd.	Contractible annuloplasty structures
US9636224B2 (en)	2008-12-22	2017-05-02	Valtech Cardio, Ltd.	Deployment techniques for annuloplasty ring and over-wire rotation tool
US8926696B2 (en)	2008-12-22	2015-01-06	Valtech Cardio, Ltd.	Adjustable annuloplasty devices and adjustment mechanisms therefor
US9277994B2 (en)	2008-12-22	2016-03-08	Valtech Cardio, Ltd.	Implantation of repair chords in the heart
US20100161043A1 (en) *	2008-12-22	2010-06-24	Valtech Cardio, Ltd.	Implantation of repair chords in the heart
US10350068B2 (en)	2009-02-17	2019-07-16	Valtech Cardio, Ltd.	Actively-engageable movement-restriction mechanism for use with an annuloplasty structure
US9561104B2 (en)	2009-02-17	2017-02-07	Valtech Cardio, Ltd.	Actively-engageable movement-restriction mechanism for use with an annuloplasty structure
US11202709B2 (en)	2009-02-17	2021-12-21	Valtech Cardio Ltd.	Actively-engageable movement-restriction mechanism for use with an annuloplasty structure
US9480562B2 (en) *	2009-03-31	2016-11-01	The Cleveland Clinic Foundation	Pre-sized prosthetic chordae implantation system
US10368987B2 (en)	2009-03-31	2019-08-06	The Cleveland Clinic Foundation	Pre-sized prosthetic chordae implantation system
US20140107769A1 (en) *	2009-03-31	2014-04-17	The Cleveland Clinic Foundation	Pre-sized prosthetic chordae implantation system
US11389296B2 (en)	2009-03-31	2022-07-19	The Cleveland Clinic Foundation	Pre-sized prosthetic chordae implantation system
US12350149B2 (en)	2009-05-04	2025-07-08	Edwards Lifesciences Innovation (Israel) Ltd.	Method and apparatus for repairing a heart valve
US9474606B2 (en)	2009-05-04	2016-10-25	Valtech Cardio, Ltd.	Over-wire implant contraction methods
US11766327B2 (en)	2009-05-04	2023-09-26	Edwards Lifesciences Innovation (Israel) Ltd.	Implantation of repair chords in the heart
US10548729B2 (en)	2009-05-04	2020-02-04	Valtech Cardio, Ltd.	Deployment techniques for annuloplasty ring and over-wire rotation tool
US9968452B2 (en)	2009-05-04	2018-05-15	Valtech Cardio, Ltd.	Annuloplasty ring delivery cathethers
US20100280603A1 (en) *	2009-05-04	2010-11-04	Valtech Cardio, Ltd.	Implantation of repair chords in the heart
US20100280604A1 (en) *	2009-05-04	2010-11-04	Valtech Cardio, Ltd.	Over-wire rotation tool
US8500800B2 (en)	2009-05-04	2013-08-06	Valtech Cardio Ltd.	Implantation of repair chords in the heart
US8545553B2 (en)	2009-05-04	2013-10-01	Valtech Cardio, Ltd.	Over-wire rotation tool
US12350158B2 (en)	2009-05-04	2025-07-08	Edwards Lifesciences Innovation (Israel) Ltd.	Annuloplasty ring delivery catheters
US11076958B2 (en)	2009-05-04	2021-08-03	Valtech Cardio, Ltd.	Annuloplasty ring delivery catheters
US11844665B2 (en)	2009-05-04	2023-12-19	Edwards Lifesciences Innovation (Israel) Ltd.	Deployment techniques for annuloplasty structure
US11185412B2 (en)	2009-05-04	2021-11-30	Valtech Cardio Ltd.	Deployment techniques for annuloplasty implants
US10856987B2 (en)	2009-05-07	2020-12-08	Valtech Cardio, Ltd.	Multiple anchor delivery tool
US12485010B2 (en)	2009-05-07	2025-12-02	Edwards Lifesciences Innovation (Israel) Ltd.	Multiple anchor delivery tool
US8715342B2 (en)	2009-05-07	2014-05-06	Valtech Cardio, Ltd.	Annuloplasty ring with intra-ring anchoring
US9119719B2 (en)	2009-05-07	2015-09-01	Valtech Cardio, Ltd.	Annuloplasty ring with intra-ring anchoring
US9937042B2 (en)	2009-05-07	2018-04-10	Valtech Cardio, Ltd.	Multiple anchor delivery tool
US9592122B2 (en)	2009-05-07	2017-03-14	Valtech Cardio, Ltd	Annuloplasty ring with intra-ring anchoring
US11723774B2 (en)	2009-05-07	2023-08-15	Edwards Lifesciences Innovation (Israel) Ltd.	Multiple anchor delivery tool
US12097118B2 (en)	2009-10-29	2024-09-24	Edwards Lifesciences Innovation (Israel) Ltd.	Tissue anchor for heart implant
US10098737B2 (en)	2009-10-29	2018-10-16	Valtech Cardio, Ltd.	Tissue anchor for annuloplasty device
US20160058557A1 (en) *	2009-10-29	2016-03-03	Valtech Cardio, Ltd.	Apparatus and method for guide-wire based advancement of a rotation assembly
US9968454B2 (en) *	2009-10-29	2018-05-15	Valtech Cardio, Ltd.	Techniques for guide-wire based advancement of artificial chordae
US9011520B2 (en)	2009-10-29	2015-04-21	Valtech Cardio, Ltd.	Tissue anchor for annuloplasty device
US9414921B2 (en)	2009-10-29	2016-08-16	Valtech Cardio, Ltd.	Tissue anchor for annuloplasty device
US11141271B2 (en)	2009-10-29	2021-10-12	Valtech Cardio Ltd.	Tissue anchor for annuloplasty device
US9180007B2 (en)	2009-10-29	2015-11-10	Valtech Cardio, Ltd.	Apparatus and method for guide-wire based advancement of an adjustable implant
US10751184B2 (en)	2009-10-29	2020-08-25	Valtech Cardio, Ltd.	Apparatus and method for guide-wire based advancement of an adjustable implant
US11617652B2 (en)	2009-10-29	2023-04-04	Edwards Lifesciences Innovation (Israel) Ltd.	Apparatus and method for guide-wire based advancement of an adjustable implant
US10492909B2 (en)	2009-12-02	2019-12-03	Valtech Cardio, Ltd.	Tool for actuating an adjusting mechanism
US11602434B2 (en)	2009-12-02	2023-03-14	Edwards Lifesciences Innovation (Israel) Ltd.	Systems and methods for tissue adjustment
US8734467B2 (en)	2009-12-02	2014-05-27	Valtech Cardio, Ltd.	Delivery tool for implantation of spool assembly coupled to a helical anchor
US9622861B2 (en)	2009-12-02	2017-04-18	Valtech Cardio, Ltd.	Tool for actuating an adjusting mechanism
US20240407914A1 (en) *	2009-12-04	2024-12-12	Edwards Lifesciences Corporation	Prosthetic valve having a multi-part frame
US12409031B2 (en) *	2009-12-04	2025-09-09	Edwards Lifesciences Corporation	Prosthetic valve having a multi-part frame
US11141268B2 (en)	2009-12-08	2021-10-12	Cardiovalve Ltd.	Prosthetic heart valve with upper and lower skirts
US10548726B2 (en)	2009-12-08	2020-02-04	Cardiovalve Ltd.	Rotation-based anchoring of an implant
US10660751B2 (en)	2009-12-08	2020-05-26	Cardiovalve Ltd.	Prosthetic heart valve with upper skirt
US10231831B2 (en)	2009-12-08	2019-03-19	Cardiovalve Ltd.	Folding ring implant for heart valve
US11351026B2 (en)	2009-12-08	2022-06-07	Cardiovalve Ltd.	Rotation-based anchoring of an implant
US11839541B2 (en)	2009-12-08	2023-12-12	Cardiovalve Ltd.	Prosthetic heart valve with upper skirt
US10548730B2 (en)	2010-02-03	2020-02-04	Edwards Lifesciences Corporation	Devices for remodeling a valve annulus and ventricle
US20110190879A1 (en) *	2010-02-03	2011-08-04	Edwards Lifesciences Corporation	Devices and Methods for Treating a Heart
US9107749B2 (en)	2010-02-03	2015-08-18	Edwards Lifesciences Corporation	Methods for treating a heart
US12016776B2 (en)	2010-02-03	2024-06-25	Edwards Lifesciences Corporation	Devices for remodeling a valve annulus and ventricle
US20110264208A1 (en) *	2010-04-27	2011-10-27	Medtronic, Inc.	Prosthetic Heart Valve Devices and Methods of Valve Repair
US9795482B2 (en) *	2010-04-27	2017-10-24	Medtronic, Inc.	Prosthetic heart valve devices and methods of valve repair
US11653910B2 (en)	2010-07-21	2023-05-23	Cardiovalve Ltd.	Helical anchor implantation
US12310575B2 (en)	2010-07-21	2025-05-27	Cardiovalve Ltd.	Helical anchor implantation
WO2012040865A1 (fr)	2010-10-01	2012-04-05	Alberto Weber	Appareil médical et procédé de réparation d'une valvule cardiaque
US9554906B2 (en)	2010-11-18	2017-01-31	Pavillion Medical Innovations, LLC	Tissue restraining devices and methods of use
US9198756B2 (en)	2010-11-18	2015-12-01	Pavilion Medical Innovations, Llc	Tissue restraining devices and methods of use
US9289295B2 (en)	2010-11-18	2016-03-22	Pavilion Medical Innovations, Llc	Tissue restraining devices and methods of use
US20240325730A1 (en) *	2010-12-29	2024-10-03	Medtronic, Inc.	Implantable medical device fixation
US12268868B2 (en)	2010-12-29	2025-04-08	Medtronic, Inc.	Implantable medical device fixation
US12268867B2 (en) *	2010-12-29	2025-04-08	Medtronic, Inc.	Implantable medical device fixation
US11974920B2 (en) *	2011-06-01	2024-05-07	Neochord, Inc.	Minimally invasive repair of heart valve leaflets
US20200368022A1 (en) *	2011-06-01	2020-11-26	Neochord, Inc.	Minimally Invasive Repair of Heart Valve Leaflets
US12409032B2 (en)	2011-06-23	2025-09-09	Edwards Lifesciences Innovation (Israel) Ltd.	Percutaneous implantation of an annuloplasty structure
US8940044B2 (en)	2011-06-23	2015-01-27	Valtech Cardio, Ltd.	Closure element for use with an annuloplasty structure
US12138165B2 (en)	2011-06-23	2024-11-12	Edwards Lifesciences Innovation (Israel) Ltd.	Annuloplasty implants
US10792152B2 (en)	2011-06-23	2020-10-06	Valtech Cardio, Ltd.	Closed band for percutaneous annuloplasty
US9775709B2 (en)	2011-11-04	2017-10-03	Valtech Cardio, Ltd.	Implant having multiple adjustable mechanisms
US9265608B2 (en)	2011-11-04	2016-02-23	Valtech Cardio, Ltd.	Implant having multiple rotational assemblies
US8858623B2 (en)	2011-11-04	2014-10-14	Valtech Cardio, Ltd.	Implant having multiple rotational assemblies
US10363136B2 (en)	2011-11-04	2019-07-30	Valtech Cardio, Ltd.	Implant having multiple adjustment mechanisms
US11197759B2 (en)	2011-11-04	2021-12-14	Valtech Cardio Ltd.	Implant having multiple adjusting mechanisms
US12274620B2 (en)	2011-11-04	2025-04-15	Edwards Lifesciences Innovation (Israel) Ltd.	Implant having multiple adjusting mechanisms
US9724192B2 (en)	2011-11-08	2017-08-08	Valtech Cardio, Ltd.	Controlled steering functionality for implant-delivery tool
US11857415B2 (en)	2011-11-08	2024-01-02	Edwards Lifesciences Innovation (Israel) Ltd.	Controlled steering functionality for implant-delivery tool
US10568738B2 (en)	2011-11-08	2020-02-25	Valtech Cardio, Ltd.	Controlled steering functionality for implant-delivery tool
US11969348B2 (en)	2011-12-12	2024-04-30	Edwards Lifesciences Corporation	Cardiac valve replacement
US11759318B2 (en)	2012-07-28	2023-09-19	Tendyne Holdings, Inc.	Multi-component designs for heart valve retrieval device, sealing structures and stent assembly
US11090155B2 (en) *	2012-07-30	2021-08-17	Tendyne Holdings, Inc.	Delivery systems and methods for transcatheter prosthetic valves
US10987219B2 (en)	2012-08-17	2021-04-27	On-X Life Technologies, Inc	Biological chord repair system and methods
US10022224B2 (en)	2012-08-17	2018-07-17	On-X Life Technologies, Inc.	Biological chord repair system and methods
US12076242B2 (en)	2012-08-17	2024-09-03	On-X Life Technologies, Inc.	Biological chord repair system and methods
US11395648B2 (en)	2012-09-29	2022-07-26	Edwards Lifesciences Corporation	Plication lock delivery system and method of use thereof
US20150157311A1 (en) *	2012-10-16	2015-06-11	Rasiklal Shamji Shah	Laparoscopic device for anchoring an organ to thoracic diaphragm
US9566059B2 (en) *	2012-10-16	2017-02-14	Rasiklal Shamji Shah	Laparoscopic device for anchoring an organ to thoracic diaphragm
US9949828B2 (en)	2012-10-23	2018-04-24	Valtech Cardio, Ltd.	Controlled steering functionality for implant-delivery tool
US12414772B2 (en)	2012-10-23	2025-09-16	Edwards Lifesciences Innovation (Israel) Ltd.	Percutaneous tissue anchor techniques
US11890190B2 (en)	2012-10-23	2024-02-06	Edwards Lifesciences Innovation (Israel) Ltd.	Location indication system for implant-delivery tool
US10893939B2 (en)	2012-10-23	2021-01-19	Valtech Cardio, Ltd.	Controlled steering functionality for implant delivery tool
US10376266B2 (en)	2012-10-23	2019-08-13	Valtech Cardio, Ltd.	Percutaneous tissue anchor techniques
US11344310B2 (en)	2012-10-23	2022-05-31	Valtech Cardio Ltd.	Percutaneous tissue anchor techniques
US12274618B2 (en)	2012-10-23	2025-04-15	Edwards Lifesciences Innovation (Israel) Ltd.	Location indication system for implant-delivery tool
US10610360B2 (en)	2012-12-06	2020-04-07	Valtech Cardio, Ltd.	Techniques for guide-wire based advancement of a tool
US9730793B2 (en)	2012-12-06	2017-08-15	Valtech Cardio, Ltd.	Techniques for guide-wire based advancement of a tool
US12251307B2 (en)	2012-12-06	2025-03-18	Edwards Lifesciences Innovation (Israel) Ltd.	Techniques for guide-wire based advancement of a tool
US11583400B2 (en)	2012-12-06	2023-02-21	Edwards Lifesciences Innovation (Israel) Ltd.	Techniques for guided advancement of a tool
US10499941B2 (en)	2012-12-14	2019-12-10	Mayo Foundation For Medical Education And Research	Mitral valve repair devices
US11844691B2 (en)	2013-01-24	2023-12-19	Cardiovalve Ltd.	Partially-covered prosthetic valves
US11793505B2 (en)	2013-02-26	2023-10-24	Edwards Lifesciences Corporation	Devices and methods for percutaneous tricuspid valve repair
US10918374B2 (en)	2013-02-26	2021-02-16	Edwards Lifesciences Corporation	Devices and methods for percutaneous tricuspid valve repair
US12419633B2 (en)	2013-02-26	2025-09-23	Edwards Lifesciences Corporation	Devices and methods for percutaneous tricuspid valve repair
US10449333B2 (en)	2013-03-14	2019-10-22	Valtech Cardio, Ltd.	Guidewire feeder
US11534583B2 (en)	2013-03-14	2022-12-27	Valtech Cardio Ltd.	Guidewire feeder
US12156981B2 (en)	2013-03-14	2024-12-03	Edwards Lifesciences Innovation (Israel) Ltd.	Guidewire feeder
US10682232B2 (en)	2013-03-15	2020-06-16	Edwards Lifesciences Corporation	Translation catheters, systems, and methods of use thereof
US11890194B2 (en)	2013-03-15	2024-02-06	Edwards Lifesciences Corporation	Translation catheters, systems, and methods of use thereof
US10918373B2 (en)	2013-08-31	2021-02-16	Edwards Lifesciences Corporation	Devices and methods for locating and implanting tissue anchors at mitral valve commissure
US11744573B2 (en)	2013-08-31	2023-09-05	Edwards Lifesciences Corporation	Devices and methods for locating and implanting tissue anchors at mitral valve commissure
US12396720B2 (en)	2013-08-31	2025-08-26	Edwards Lifesciences Corporation	Devices and methods for locating and implanting tissue anchors at mitral valve commissure
US10299793B2 (en)	2013-10-23	2019-05-28	Valtech Cardio, Ltd.	Anchor magazine
US11766263B2 (en)	2013-10-23	2023-09-26	Edwards Lifesciences Innovation (Israel) Ltd.	Anchor magazine
US12408918B2 (en)	2013-10-23	2025-09-09	Edwards Lifesciences Innovation (Israel) Ltd.	Anchor magazine
US11065001B2 (en)	2013-10-23	2021-07-20	Valtech Cardio, Ltd.	Anchor magazine
US10265170B2 (en)	2013-12-26	2019-04-23	Valtech Cardio, Ltd.	Implantation of flexible implant
US9610162B2 (en)	2013-12-26	2017-04-04	Valtech Cardio, Ltd.	Implantation of flexible implant
US10973637B2 (en)	2013-12-26	2021-04-13	Valtech Cardio, Ltd.	Implantation of flexible implant
US11678872B2 (en)	2014-01-03	2023-06-20	University Of Maryland, Baltimore	Method and apparatus for transapical procedures on a mitral valve
WO2015103434A1 (fr)	2014-01-03	2015-07-09	Tozzi Luigi P	Appareil et procédé pour remodeler la géométrie d'une valve cardiaque malade
EP3089706A4 (fr) *	2014-01-03	2017-08-30	Luigi P. Tozzi	Appareil et procédé pour remodeler la géométrie d'une valve cardiaque malade
US10667804B2 (en) *	2014-03-17	2020-06-02	Evalve, Inc.	Mitral valve fixation device removal devices and methods
US9572666B2 (en) *	2014-03-17	2017-02-21	Evalve, Inc.	Mitral valve fixation device removal devices and methods
US10390943B2 (en)	2014-03-17	2019-08-27	Evalve, Inc.	Double orifice device for transcatheter mitral valve replacement
US11666433B2 (en)	2014-03-17	2023-06-06	Evalve, Inc.	Double orifice device for transcatheter mitral valve replacement
US20170143330A1 (en) *	2014-03-17	2017-05-25	Evalve, Inc.	Mitral valve fixation device removal devices and methods
US12213661B2 (en)	2014-03-17	2025-02-04	Evalve, Inc.	Mitral valve fixation device removal devices and methods
US20150257883A1 (en) *	2014-03-17	2015-09-17	Evalve, Inc.	Mitral valve fixation device removal devices and methods
EP3146904A4 (fr) *	2014-05-20	2018-01-24	Taupnumedical Co., Ltd	Dispositif de protection des tissus pour procédure de cerclage d'une membrane de valvule mitrale
EP3158940A4 (fr) *	2014-06-17	2018-01-24	Taupnumedical Co. Ltd.	Dispositif de protection de tissu pour une chirurgie de régurgitation tricuspidienne
US10973524B2 (en)	2014-06-17	2021-04-13	Tau-Pnu Medical Co., Ltd.	Device for transcatheter treatment for tricuspid regurgitation
WO2016008058A1 (fr)	2014-07-17	2016-01-21	Coremedic Ag	Appareil et procédé médicaux pour réparation de valvule cardiaque
US10405979B2 (en)	2014-07-17	2019-09-10	Coremedic Ag	Medical apparatus and method for heart valve repair
US12053380B2 (en)	2014-07-30	2024-08-06	Cardiovalve Ltd.	Anchoring of a prosthetic valve
EP3505077A1 (fr) *	2014-09-17	2019-07-03	Cardiomech AS	Dispositif de réparation du coeur
EP3193740B1 (fr) *	2014-09-17	2021-07-21	Cardiomech AS	Dispositif pour réparation cardiaque
US11253247B2 (en)	2014-09-17	2022-02-22	Cardiomech As	Device for heart repair
US10945718B2 (en)	2014-09-17	2021-03-16	Cardiomech As	Device for heart repair
US11071628B2 (en)	2014-10-14	2021-07-27	Valtech Cardio, Ltd.	Leaflet-restraining techniques
US10195030B2 (en)	2014-10-14	2019-02-05	Valtech Cardio, Ltd.	Leaflet-restraining techniques
WO2016126699A1 (fr) *	2015-02-02	2016-08-11	On-X Life Technologies, Inc.	Système de cordage tendineux artificiel à déploiement rapide
US10213303B2 (en)	2015-02-02	2019-02-26	On-X Life Technologies, Inc.	Rapid deployment artificial chordae Tendinae system
US9480565B2 (en)	2015-02-02	2016-11-01	On-X Life Technologies, Inc.	Rapid deployment artificial chordae tendinae system
US11801135B2 (en)	2015-02-05	2023-10-31	Cardiovalve Ltd.	Techniques for deployment of a prosthetic valve
US12396851B2 (en)	2015-02-05	2025-08-26	Cardiovalve Ltd.	Prosthetic valve with arms and flanges
US10925610B2 (en)	2015-03-05	2021-02-23	Edwards Lifesciences Corporation	Devices for treating paravalvular leakage and methods use thereof
US10765514B2 (en)	2015-04-30	2020-09-08	Valtech Cardio, Ltd.	Annuloplasty technologies
US12138164B2 (en)	2015-04-30	2024-11-12	Edwards Lifesciences Innovation (Israel) Ltd.	Annuloplasty technologies
US11590321B2 (en)	2015-06-19	2023-02-28	Evalve, Inc.	Catheter guiding system and methods
US12201525B2 (en)	2015-10-02	2025-01-21	Harpoon Medical, Inc.	Tissue anchor deployment
JP2018531092A (ja) *	2015-10-21	2018-10-25	コアメディックアーゲーＣｏｒｅｍｅｄｉｃＡｇ	心臓弁の修復用の医療インプラントおよび方法
CN112618107A (zh) *	2015-10-21	2021-04-09	核心医疗股份公司	用于心脏瓣膜修复的医学植入物及方法
US11510782B2 (en) *	2015-10-27	2022-11-29	Xetis AG	Medical device using bioabsorbable material
US20180235758A1 (en) *	2015-10-27	2018-08-23	Xeltis, Bv	Medical device using bioabsorbable material
US12318296B2 (en)	2015-12-30	2025-06-03	Pipeline Medical Technologies, Inc.	Mitral leaflet tethering
US11890193B2 (en)	2015-12-30	2024-02-06	Edwards Lifesciences Corporation	System and method for reducing tricuspid regurgitation
US10751182B2 (en)	2015-12-30	2020-08-25	Edwards Lifesciences Corporation	System and method for reshaping right heart
US10828160B2 (en)	2015-12-30	2020-11-10	Edwards Lifesciences Corporation	System and method for reducing tricuspid regurgitation
US11660192B2 (en)	2015-12-30	2023-05-30	Edwards Lifesciences Corporation	System and method for reshaping heart
US11937795B2 (en)	2016-02-16	2024-03-26	Cardiovalve Ltd.	Techniques for providing a replacement valve and transseptal communication
US12295844B2 (en)	2016-04-22	2025-05-13	Edwards Lifesciences Corporation	Artificial chordae deployment
US11529233B2 (en)	2016-04-22	2022-12-20	Edwards Lifesciences Corporation	Beating-heart mitral valve chordae replacement
US10702274B2 (en)	2016-05-26	2020-07-07	Edwards Lifesciences Corporation	Method and system for closing left atrial appendage
US11540835B2 (en)	2016-05-26	2023-01-03	Edwards Lifesciences Corporation	Method and system for closing left atrial appendage
US11103350B2 (en)	2016-06-01	2021-08-31	On-X Life Technologies, Inc.	Pull-through chordae tendineae system
US12193935B2 (en)	2016-06-01	2025-01-14	On-X Life Technologies, Inc.	Pull-through chordae tendineae system
US12408917B2 (en)	2016-07-06	2025-09-09	Evalve, Inc.	Methods and devices for valve clip excision
US10736632B2 (en)	2016-07-06	2020-08-11	Evalve, Inc.	Methods and devices for valve clip excision
US12128203B2 (en)	2016-07-07	2024-10-29	Primo Medical Group, Inc.	Septum for access port
US10959845B2 (en)	2016-07-08	2021-03-30	Valtech Cardio, Ltd.	Adjustable annuloplasty device with alternating peaks and troughs
US12102533B2 (en)	2016-07-08	2024-10-01	Edwards Lifesciences Innovation (Israel) Ltd.	Adjustable annuloplasty device with alternating peaks and troughs
US10226342B2 (en)	2016-07-08	2019-03-12	Valtech Cardio, Ltd.	Adjustable annuloplasty device with alternating peaks and troughs
US11324495B2 (en)	2016-07-29	2022-05-10	Cephea Valve Technologies, Inc.	Systems and methods for delivering an intravascular device to the mitral annulus
US10661052B2 (en)	2016-07-29	2020-05-26	Cephea Valve Technologies, Inc.	Intravascular device delivery sheath
US12364840B2 (en)	2016-07-29	2025-07-22	Cephea Valve Technologies, Inc.	Mechanical interlock for catheters
US11471645B2 (en)	2016-07-29	2022-10-18	Cephea Valve Technologies, Inc.	Intravascular device delivery sheath
US10974027B2 (en)	2016-07-29	2021-04-13	Cephea Valve Technologies, Inc.	Combination steerable catheter and systems
US10639151B2 (en)	2016-07-29	2020-05-05	Cephea Valve Technologies, Inc.	Threaded coil
US11793973B2 (en)	2016-07-29	2023-10-24	Cephea Valve Technologies, Inc.	Combination steerable catheter and systems
US11679236B2 (en)	2016-07-29	2023-06-20	Cephea Valve Technologies, Inc.	Mechanical interlock for catheters
US10646689B2 (en)	2016-07-29	2020-05-12	Cephea Valve Technologies, Inc.	Mechanical interlock for catheters
US12053379B2 (en)	2016-08-01	2024-08-06	Cardiovalve Ltd.	Minimally-invasive delivery systems
US11779458B2 (en)	2016-08-10	2023-10-10	Cardiovalve Ltd.	Prosthetic valve with leaflet connectors
US11109967B2 (en)	2016-08-29	2021-09-07	Cephea Valve Technologies, Inc.	Systems and methods for loading and deploying an intravascular device
US12440332B2 (en)	2016-08-29	2025-10-14	Cephea Valve Technologies, Inc.	Systems and methods for loading and deploying an intravascular device
US11045315B2 (en)	2016-08-29	2021-06-29	Cephea Valve Technologies, Inc.	Methods of steering and delivery of intravascular devices
US10933216B2 (en)	2016-08-29	2021-03-02	Cephea Valve Technologies, Inc.	Multilumen catheter
US11653947B2 (en)	2016-10-05	2023-05-23	Evalve, Inc.	Cardiac valve cutting device
US11071564B2 (en)	2016-10-05	2021-07-27	Evalve, Inc.	Cardiac valve cutting device
US11723768B2 (en)	2016-10-05	2023-08-15	Cephea Valve Technologies, Inc.	Systems and methods for delivering and deploying an artificial heart valve within the mitral annulus
US10874512B2 (en)	2016-10-05	2020-12-29	Cephea Valve Technologies, Inc.	System and methods for delivering and deploying an artificial heart valve within the mitral annulus
US10363138B2 (en)	2016-11-09	2019-07-30	Evalve, Inc.	Devices for adjusting the curvature of cardiac valve structures
US11166818B2 (en)	2016-11-09	2021-11-09	Evalve, Inc.	Devices for adjusting the curvature of cardiac valve structures
US11116633B2 (en)	2016-11-11	2021-09-14	Evalve, Inc.	Opposing disk device for grasping cardiac valve tissue
US10426616B2 (en)	2016-11-17	2019-10-01	Evalve, Inc.	Cardiac implant delivery system
US10682230B2 (en)	2016-12-30	2020-06-16	Pipeline Medical Technologies, Inc.	Apparatus for transvascular implantation of neo chordae tendinae
US10675150B2 (en)	2016-12-30	2020-06-09	Pipeline Medical Technologies, Inc.	Method for transvascular implantation of neo chordae tendinae
US10925731B2 (en)	2016-12-30	2021-02-23	Pipeline Medical Technologies, Inc.	Method and apparatus for transvascular implantation of neo chordae tendinae
US11666441B2 (en)	2016-12-30	2023-06-06	Pipeline Medical Technologies, Inc.	Endovascular suture lock
US11083580B2 (en)	2016-12-30	2021-08-10	Pipeline Medical Technologies, Inc.	Method of securing a leaflet anchor to a mitral valve leaflet
US11690719B2 (en)	2016-12-30	2023-07-04	Pipeline Medical Technologies, Inc.	Leaflet capture and anchor deployment system
US11684475B2 (en)	2016-12-30	2023-06-27	Pipeline Medical Technologies, Inc.	Method and apparatus for transvascular implantation of neo chordae tendinae
US12213883B2 (en)	2016-12-30	2025-02-04	Pipeline Medical Technologies, Inc.	Method and apparatus for transvascular implantation of neo chordae tendinae
US12472062B2 (en)	2016-12-30	2025-11-18	Pipeline Medical Technologies, Inc.	Method and apparatus for mitral valve chord repair
US11696828B2 (en)	2016-12-30	2023-07-11	Pipeline Medical Technologies, Inc.	Method and apparatus for mitral valve chord repair
US10667910B2 (en)	2016-12-30	2020-06-02	Pipeline Medical Technologies, Inc.	Method and apparatus for transvascular implantation of neo chordae tendinae
JP2024073411A (ja) *	2016-12-30	2024-05-29	パイプラインメディカルテクノロジーズ，インコーポレイテッド	僧帽弁弁尖拘束部
US12357462B2 (en)	2016-12-30	2025-07-15	Pipeline Medical Technologies, Inc.	Method and apparatus for transvascular implantation of neo chordae tendinae
JP2020503165A (ja) *	2016-12-30	2020-01-30	パイプラインメディカルテクノロジーズ，インコーポレイテッド	新生腱索の経血管的埋め込み方法及び装置
JP7136806B2 (ja)	2016-12-30	2022-09-13	パイプラインメディカルテクノロジーズ，インコーポレイテッド	新生腱索の経血管的埋め込み方法及び装置
US11931262B2 (en)	2016-12-30	2024-03-19	Pipeline Medical Technologies, Inc.	Method and apparatus for transvascular implantation of neo chordae tendinae
US10660753B2 (en)	2016-12-30	2020-05-26	Pipeline Medical Techologies, Inc.	Leaflet capture and anchor deployment system
US10617523B2 (en)	2016-12-30	2020-04-14	Pipeline Medical Technologies, Inc.	Tissue anchor with dynamic depth indicator
US10548733B2 (en) *	2016-12-30	2020-02-04	Pipeline Medical Technologies, Inc.	Method of transvascular prosthetic chordae tendinae implantation
US11285000B2 (en)	2017-02-01	2022-03-29	Tau Pnu Medical Co., Ltd.	Tool for tricuspid regurgitation operation
US10213306B2 (en)	2017-03-31	2019-02-26	Neochord, Inc.	Minimally invasive heart valve repair in a beating heart
US12208009B2 (en)	2017-03-31	2025-01-28	Neochord, Inc.	Minimally invasive heart valve repair in a beating heart
US11589989B2 (en)	2017-03-31	2023-02-28	Neochord, Inc.	Minimally invasive heart valve repair in a beating heart
US11045627B2 (en)	2017-04-18	2021-06-29	Edwards Lifesciences Corporation	Catheter system with linear actuation control mechanism
US11883611B2 (en)	2017-04-18	2024-01-30	Edwards Lifesciences Corporation	Catheter system with linear actuation control mechanism
US11026672B2 (en)	2017-06-19	2021-06-08	Harpoon Medical, Inc.	Method and apparatus for cardiac procedures
US12370048B2 (en)	2017-07-24	2025-07-29	Emory University	Cardiac valve leaflet enhancer devices and systems
US12290439B2 (en)	2017-07-24	2025-05-06	Emory University	Cardiac valve leaflet enhancer devices and systems
US12064347B2 (en)	2017-08-03	2024-08-20	Cardiovalve Ltd.	Prosthetic heart valve
US12232958B2 (en)	2017-08-03	2025-02-25	Cardiovalve Ltd.	Prosthetic heart valve
US12090048B2 (en)	2017-08-03	2024-09-17	Cardiovalve Ltd.	Prosthetic heart valve
US12029646B2 (en)	2017-08-03	2024-07-09	Cardiovalve Ltd.	Prosthetic heart valve
US11819409B2 (en)	2017-08-17	2023-11-21	Hangzhou Valgen Medtech Co., Ltd.	Artificial chordae tendineae implantation system and clamp aiding apparatus thereof
WO2019034081A1 (fr) *	2017-08-17	2019-02-21	杭州德晋医疗科技有限公司	Système d'implantation de cordages tendineux artificiels et appareil d'aide au serrage associé
US12458493B2 (en)	2017-09-19	2025-11-04	Cardiovalve Ltd.	Prosthetic heart valve and delivery systems and methods
US11832784B2 (en)	2017-11-02	2023-12-05	Edwards Lifesciences Innovation (Israel) Ltd.	Implant-cinching devices and systems
US10835221B2 (en)	2017-11-02	2020-11-17	Valtech Cardio, Ltd.	Implant-cinching devices and systems
US11135062B2 (en)	2017-11-20	2021-10-05	Valtech Cardio Ltd.	Cinching of dilated heart muscle
US12364605B2 (en)	2017-11-20	2025-07-22	Edwards Lifesciences Innovation (Israel) Ltd.	Cinching of dilated heart muscle
WO2019105073A1 (fr) *	2017-11-28	2019-06-06	杭州德晋医疗科技有限公司	Système d'implantation de cordages tendineux artificiels à deux côtés
US12485009B2 (en)	2017-12-20	2025-12-02	W. L. Gore & Associates, Inc.	Artificial chordae tendineae repair devices and delivery thereof
US11478351B2 (en) *	2018-01-22	2022-10-25	Edwards Lifesciences Corporation	Heart shape preserving anchor
US11779463B2 (en)	2018-01-24	2023-10-10	Edwards Lifesciences Innovation (Israel) Ltd.	Contraction of an annuloplasty structure
US11666442B2 (en)	2018-01-26	2023-06-06	Edwards Lifesciences Innovation (Israel) Ltd.	Techniques for facilitating heart valve tethering and chord replacement
WO2019145941A1 (fr) *	2018-01-26	2019-08-01	Valtech Cardio, Ltd.	Techniques pour faciliter la fixation de valve cardiaque et le remplacement de cordon
US20220305251A1 (en) *	2018-03-05	2022-09-29	Harmony Development Group, Inc.	Force transducting implant system for the mitigation of atrioventricular pressure gradient loss and the restoration of healthy ventricular geometry
US11026791B2 (en)	2018-03-20	2021-06-08	Medtronic Vascular, Inc.	Flexible canopy valve repair systems and methods of use
US12343257B2 (en)	2018-03-20	2025-07-01	Medtronic Vascular, Inc.	Prolapse prevention device and methods of use thereof
US11931261B2 (en)	2018-03-20	2024-03-19	Medtronic Vascular, Inc.	Prolapse prevention device and methods of use thereof
US11701228B2 (en)	2018-03-20	2023-07-18	Medtronic Vascular, Inc.	Flexible canopy valve repair systems and methods of use
US11285003B2 (en)	2018-03-20	2022-03-29	Medtronic Vascular, Inc.	Prolapse prevention device and methods of use thereof
US11612389B2 (en)	2018-03-23	2023-03-28	Neochord, Inc.	Device for suture attachment for minimally invasive heart valve repair
US12310577B2 (en)	2018-03-23	2025-05-27	Neochord, Inc.	Device for suture attachment for minimally invasive heart valve repair
FR3079409A1 (fr) *	2018-04-03	2019-10-04	Seguin Jacques	Systeme de traitement d'une valve cardiaque, en particulier une valve mitrale ou tricuspide
US11957584B2 (en)	2018-05-09	2024-04-16	Neochord, Inc.	Suture length adjustment for minimally invasive heart valve repair
US11253360B2 (en)	2018-05-09	2022-02-22	Neochord, Inc.	Low profile tissue anchor for minimally invasive heart valve repair
US11173030B2 (en)	2018-05-09	2021-11-16	Neochord, Inc.	Suture length adjustment for minimally invasive heart valve repair
EP3790509A4 (fr) *	2018-05-09	2022-03-09	NeoChord, Inc.	Systèmes et procédés de réparation de valvule cardiaque par transcathéter
WO2019217638A1 (fr) *	2018-05-09	2019-11-14	Neochord, Inc.	Systèmes et procédés de réparation de valvule cardiaque par transcathéter
US12290438B2 (en)	2018-05-22	2025-05-06	Boston Scientific Scimed, Inc.	Percutaneous papillary muscle relocation
US11678988B2 (en)	2018-05-22	2023-06-20	Boston Scientific Scimed, Inc.	Percutaneous papillary muscle relocation
US11147673B2 (en)	2018-05-22	2021-10-19	Boston Scientific Scimed, Inc.	Percutaneous papillary muscle relocation
US11123191B2 (en)	2018-07-12	2021-09-21	Valtech Cardio Ltd.	Annuloplasty systems and locking tools therefor
US11890191B2 (en)	2018-07-12	2024-02-06	Edwards Lifesciences Innovation (Israel) Ltd.	Fastener and techniques therefor
US12137897B2 (en)	2018-09-07	2024-11-12	Neochord, Inc.	Device for suture attachment for minimally invasive heart valve repair
CN110897763A (zh) *	2018-09-17	2020-03-24	东莞市先健医疗有限公司	医疗器械输送装置
US12102531B2 (en)	2018-10-22	2024-10-01	Evalve, Inc.	Tissue cutting systems, devices and methods
US11724068B2 (en)	2018-11-16	2023-08-15	Cephea Valve Technologies, Inc.	Intravascular delivery system
US12350157B2 (en)	2018-11-29	2025-07-08	Cardiomech As	Device for heart repair
WO2020109582A1 (fr) *	2018-11-29	2020-06-04	Cardiomech As	Dispositif pour réparation cardiaque
CN113347946A (zh) *	2018-11-29	2021-09-03	卡尔迪欧迈科公司	心脏修复装置
GB2579433A (en) *	2018-11-29	2020-06-24	Cardiomech As	Device for heart repair
JP2022509308A (ja) *	2018-11-29	2022-01-20	カーディオメクアクティーゼルスカブ	心臓修復デバイス
US20220117734A1 (en) *	2018-11-29	2022-04-21	Cardiomech As	Device for Heart Repair
JP7526726B2 (ja)	2018-11-29	2024-08-01	カーディオメクアクティーゼルスカブ	アンカー、カテーテルデバイス、及びアンカーを製造する方法
GB2579433B (en) *	2018-11-29	2021-01-20	Cardiomech As	Device for heart repair
EP3917455A4 (fr) *	2019-01-28	2023-04-05	Vesalius Cardiovascular Inc.	Appareil destiné à être utilisé dans la réparation de valves mitrales et son procédé d'utilisation
US20220142778A1 (en) *	2019-01-28	2022-05-12	Vesalius Cardiovascular Inc.	Apparatus for use in repairing mitral valves and method of use thereof
US11963874B2 (en)	2019-01-28	2024-04-23	Vesalius Cardiovascular Inc.	Apparatus for use in repairing mitral valves and method of use thereof
US12440206B2 (en)	2019-02-12	2025-10-14	Edwards Lifesciences Corporation	Controlled tissue anchor spacing
US11376126B2 (en)	2019-04-16	2022-07-05	Neochord, Inc.	Transverse helical cardiac anchor for minimally invasive heart valve repair
CN114206265A (zh) *	2019-04-16	2022-03-18	尼奥绰德有限公司	用于微创心脏瓣膜修复的横向螺旋心脏锚固器
US11918468B2 (en)	2019-04-16	2024-03-05	Neochord, Inc.	Transverse helical cardiac anchor for minimally invasive heart valve repair
EP3955855A4 (fr) *	2019-04-16	2023-01-25	NeoChord, Inc.	Ancrage cardiaque hélicoïdal transversal pour réparation de valvule cardiaque minimalement invasive
US12226096B2 (en)	2019-05-29	2025-02-18	Edwards Lifesciences Innovation (Israel) Ltd.	Tissue anchor handling systems and methods
EP4454611A3 (fr) *	2019-07-03	2024-11-20	Boston Scientific Scimed, Inc.	Système d'ancrage d'un cordage tendineux artificiel à un muscle papillaire ou à une paroi cardiaque
CN114007550A (zh) *	2019-07-03	2022-02-01	波士顿科学国际有限公司	用于将人工腱索锚固在乳头肌或心壁上的装置、系统和方法
JP2022532500A (ja) *	2019-07-03	2022-07-15	ボストンサイエンティフィックサイムド，インコーポレイテッド	人工腱索を乳頭筋または心臓壁に係留するための装置、システムおよび方法
US11903831B2 (en)	2019-07-03	2024-02-20	Boston Scientific Scimed, Inc.	Devices, systems, and methods for anchoring an artificial chordae tendineae to a papillary muscle or heart wall
JP7410178B2 (ja)	2019-07-03	2024-01-09	ボストンサイエンティフィックサイムド，インコーポレイテッド	人工腱索を乳頭筋または心臓壁に係留するための装置、システムおよび方法
WO2021003375A1 (fr) *	2019-07-03	2021-01-07	Boston Scientific Scimed, Inc.	Dispositifs, systèmes et procédés d'ancrage d'un cordage tendineux artificiel à un muscle papillaire ou à une paroi cardiaque
US12364606B2 (en)	2019-07-23	2025-07-22	Edwards Lifesciences Innovation (Israel) Ltd.	Fluoroscopic visualization of heart valve anatomy
WO2021034538A1 (fr) *	2019-08-22	2021-02-25	Edwards Lifesciences Corporation	Accrochage de feuillet de valvule cardiaque
CN114269293A (zh) *	2019-08-22	2022-04-01	爱德华兹生命科学公司	心脏瓣膜小叶束缚
US12440648B2 (en)	2019-08-28	2025-10-14	Edwards Lifesciences Innovation (Israel) Ltd.	Low-profile steerable catheter
US12419749B2 (en)	2019-08-30	2025-09-23	Edwards Lifesciences Innovation (Israel) Ltd.	Anchor channel tip
CN114502082A (zh) *	2019-09-23	2022-05-13	W.L.戈尔及同仁股份有限公司	用于二尖瓣腱索修复的锚定件
US12208006B2 (en)	2019-09-25	2025-01-28	Edwards Lifesciences Corporation	Constricting a cardiac valve annulus using a cord that has a loop portion and a single second portion
US11819411B2 (en)	2019-10-29	2023-11-21	Edwards Lifesciences Innovation (Israel) Ltd.	Annuloplasty and tissue anchor technologies
US20240164904A1 (en) *	2019-11-07	2024-05-23	Primo Medical Group, Inc.	Systems, apparatus and methods to repair operation of a heart valve
US12465490B2 (en) *	2019-11-07	2025-11-11	Primo Medical Group, Inc.	Systems, apparatus and methods to repair operation of a heart valve
US20210137679A1 (en) *	2019-11-07	2021-05-13	Primo Medical Group, Inc.	Systems, apparatus and methods to repair operation of a heart valve
US11678985B2 (en) *	2019-11-07	2023-06-20	Primo Medical Group, Inc.	Systems, apparatus and methods to repair operation of a heart valve
US12208007B2 (en)	2020-01-16	2025-01-28	Neochord, Inc.	Helical cardiac anchors for minimally invasive heart valve repair
US12419631B2 (en)	2020-04-22	2025-09-23	Edwards Lifesciences Corporation	Controlled suture tensioning
US12171486B2 (en)	2020-05-06	2024-12-24	Evalve, Inc.	Devices and methods for clip separation
US12178444B2 (en)	2020-05-06	2024-12-31	Evalve, Inc.	Clip removal systems and methods
US12048448B2 (en)	2020-05-06	2024-07-30	Evalve, Inc.	Leaflet grasping and cutting device
US12414811B2 (en)	2020-05-06	2025-09-16	Evalve, Inc.	Devices and methods for leaflet cutting
US12171485B2 (en)	2020-05-06	2024-12-24	Evalve, Inc.	Systems and methods for leaflet cutting using a hook catheter
US12023247B2 (en)	2020-05-20	2024-07-02	Edwards Lifesciences Corporation	Reducing the diameter of a cardiac valve annulus with independent control over each of the anchors that are launched into the annulus
US12290440B2 (en)	2020-05-27	2025-05-06	Approxima Srl	Device and assembly to repair a heart valve
US12251310B2 (en)	2020-05-27	2025-03-18	Approxima Srl	Device and assembly to repair a heart valve
US11766331B2 (en)	2020-05-27	2023-09-26	Politecnico Di Milano	Device and assembly to repair a heart valve
US12350155B2 (en)	2020-06-17	2025-07-08	Pipeline Medical Technologies, Inc.	Method and apparatus for mitral valve chord repair
US12396718B2 (en)	2020-06-19	2025-08-26	Edwards Lifesciences Corporation	Self-stopping tissue anchors
US12502167B2 (en)	2020-07-14	2025-12-23	Edwards Lifesciences Corporation	Tissue remodeling systems and methods
US12369905B2 (en)	2020-09-10	2025-07-29	Edwards Lifesciences Corporation	Closing tissue openings
US12357459B2 (en)	2020-12-03	2025-07-15	Cardiovalve Ltd.	Transluminal delivery system
CN114680968A (zh) *	2020-12-31	2022-07-01	深圳市健心医疗科技有限公司	心尖闭合装置
WO2022173780A1 (fr) *	2021-02-09	2022-08-18	Edwards Lifesciences Corporation	Fils haute résistance pour interventions cardiaques
US12458498B2 (en)	2021-02-10	2025-11-04	Edwards Lifesciences Corporation	Implanting grafts to valve leaflets for cardiac procedures
CN113017927A (zh) *	2021-03-22	2021-06-25	上海骊霄医疗技术有限公司	一种可捕捉和固定的二尖瓣修复装置
US12440204B2 (en)	2022-12-06	2025-10-14	Boston Scientific Scimed, Inc.	Medical device for cutting a suture during a minimally invasive procedure
US12502170B2 (en)	2023-06-23	2025-12-23	Edwards Lifesciences Corporation	Trigger-based tissue anchor deployment
US12433749B2 (en)	2023-08-25	2025-10-07	Emory University	Systems, devices, and methods for reducing heart valve regurgitation
US12171662B1 (en)	2023-10-26	2024-12-24	Approxima Srl	Heart chamber reshaping and valve repair system
US12396855B1 (en)	2024-07-25	2025-08-26	Nyra Medical, Inc.	Systems, devices, and methods for reducing heart valve regurgitation

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Publication number	Publication date
US20170119368A1 (en)	2017-05-04
US20160346086A1 (en)	2016-12-01
EP2114304A1 (fr)	2009-11-11
US9572667B2 (en)	2017-02-21
EP3345572A1 (fr)	2018-07-11
EP2114304B1 (fr)	2017-09-06
WO2008101113A1 (fr)	2008-08-21
US20130110230A1 (en)	2013-05-02
US10154838B2 (en)	2018-12-18

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JP7661383B2 (ja)	2025-04-14	弁膜逆流の治療のための僧帽弁インプラント
US7588582B2 (en)	2009-09-15	Methods for remodeling cardiac tissue
EP3355804B1 (fr)	2020-07-15	Appareil d'ancrage distal pour réparation de valvule mitrale
CN108697418B (zh)	2022-02-18	用于二尖瓣瓣膜修复的远侧锚固设备和方法
US20120179184A1 (en)	2012-07-12	Heart valve remodeling
US20040260317A1 (en)	2004-12-23	Tensioning device, system, and method for treating mitral valve regurgitation
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EP1954214A2 (fr)	2008-08-13	Procedes, dispositifs et trousses pour le traitement du prolapsus valvulaire mitral
EP2023822A2 (fr)	2009-02-18	Méthode et appareil de réparation de la valvule mitrale à l'aide d'un cathéter
CN109152573B (zh)	2021-04-13	用于二尖瓣修复的远侧锚固件设备和方法
HK40042599A (en)	2021-09-03	Distal anchor apparatus for mitral valve repair
JP2023552437A (ja)	2023-12-15	心臓弁輪を再成形するためのデバイス、方法、及びシステム
HK40026227A (en)	2020-12-31	Delivery system and methods for reshaping a heart valve annulus, including the use of magnetic tools
HK40002341A (en)	2020-03-20	Distal anchor apparatus and methods for mitral valve repair

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