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US20070014695A1 - Systems and Methods for Multiple Analyte Detection - Google Patents

Systems and Methods for Multiple Analyte Detection Download PDF

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Publication number
US20070014695A1
US20070014695A1 US11/380,327 US38032706A US2007014695A1 US 20070014695 A1 US20070014695 A1 US 20070014695A1 US 38032706 A US38032706 A US 38032706A US 2007014695 A1 US2007014695 A1 US 2007014695A1
Authority
US
United States
Prior art keywords
sample
substrate
venting
chambers
chamber
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US11/380,327
Other languages
English (en)
Inventor
Min Yue
David Liu
Yuh-Min Chiang
Joon Mo Yang
Dennis Lehto
Charles Vann
Nigel Beard
Ian Harding
John Van Camp
Alexander Dromaretsky
Sergey Ermakov
Mark Oldham
Joy Roy
Maryam Shariati
Umberto Ulmanella
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Applied Biosystems LLC
Original Assignee
Applera Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to PCT/US2006/016060 priority Critical patent/WO2006116616A2/fr
Priority to US11/380,327 priority patent/US20070014695A1/en
Priority to EP06751668.2A priority patent/EP1885839B1/fr
Application filed by Applera Corp filed Critical Applera Corp
Assigned to APPLERA CORPORATION reassignment APPLERA CORPORATION ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: ROY, JOY, SHARIATI, MARYAM, DROMARETSKY, ALEXANDER, ERMAKOV, SERGEY V., VAN CAMP, JOHN, VANN, CHARLES S., OLDHAM, MARK F., BEARD, NIGEL P., CHIANG, YUH-MIN, LIU, DAVID M., ULMANELLA, UMBERTO, YANG, JOON MO, YUE, MIN, HARDING, IAN A., LEHTO, DENNIS
Publication of US20070014695A1 publication Critical patent/US20070014695A1/en
Assigned to BANK OF AMERICA, N.A, AS COLLATERAL AGENT reassignment BANK OF AMERICA, N.A, AS COLLATERAL AGENT SECURITY AGREEMENT Assignors: APPLIED BIOSYSTEMS, LLC
Assigned to APPLIED BIOSYSTEMS, LLC reassignment APPLIED BIOSYSTEMS, LLC MERGER Assignors: APPLIED BIOSYSTEMS INC.
Assigned to APPLIED BIOSYSTEMS INC. reassignment APPLIED BIOSYSTEMS INC. CHANGE OF NAME Assignors: APPLERA CORPORATION
Priority to US12/789,363 priority patent/US8597590B2/en
Assigned to APPLIED BIOSYSTEMS, INC. reassignment APPLIED BIOSYSTEMS, INC. LIEN RELEASE Assignors: BANK OF AMERICA, N.A.
Priority to US14/093,933 priority patent/US9714444B2/en
Assigned to APPLIED BIOSYSTEMS, LLC reassignment APPLIED BIOSYSTEMS, LLC CORRECTIVE ASSIGNMENT TO CORRECT THE RECEIVING PARTY NAME PREVIOUSLY RECORDED AT REEL: 030182 FRAME: 0677. ASSIGNOR(S) HEREBY CONFIRMS THE RELEASE OF SECURITY INTEREST. Assignors: BANK OF AMERICA, N.A.
Assigned to APPLERA CORPORATION reassignment APPLERA CORPORATION ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: ROY, JOY, SHARIATI, MARYAM, DROMARETSKY, ALEXANDER, ERMAKOV, SERGEY V., VAN CAMP, JOHN, VANN, CHARLES S., OLDHAM, MARK F., BEARD, NIGEL P., CHIANG, YUH-MIN, LIU, DAVID M., ULMANELLA, UMBERTO, YANG, JOON MO, YUE, MIN, HARDING, IAN A., LEHTO, DENNIS
Priority to US15/658,016 priority patent/US20180016624A1/en
Abandoned legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502723—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by venting arrangements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/028—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having reaction cells in the form of microtitration plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00306—Reactor vessels in a multiple arrangement
    • B01J2219/00313—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
    • B01J2219/00315—Microtiter plates
    • B01J2219/00317—Microwell devices, i.e. having large numbers of wells
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00722—Nucleotides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0684—Venting, avoiding backpressure, avoid gas bubbles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0689—Sealing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/16—Reagents, handling or storing thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/041—Connecting closures to device or container
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/046—Function or devices integrated in the closure
    • B01L2300/048—Function or devices integrated in the closure enabling gas exchange, e.g. vents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0636—Integrated biosensor, microarrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0829—Multi-well plates; Microtitration plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0864—Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/087—Multiple sequential chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0481—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure squeezing of channels or chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0633—Valves, specific forms thereof with moving parts
    • B01L2400/0655—Valves, specific forms thereof with moving parts pinch valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0694—Valves, specific forms thereof vents used to stop and induce flow, backpressure valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
    • B01L3/50853—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates with covers or lids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/2575—Volumetric liquid transfer

Definitions

  • FIGS. 10B and 10C illustrate cross-sectional views of FIG. 10A taken through line 10 C- 10 C according to various embodiments of the present teachings
  • FIGS. 12A-12B are cross-sectional views of filling and sealing the substrate of FIG. 11 according to various embodiments of the present teachings
  • the substrate material defining the upper wall of the sample chambers can be optically clear
  • the chambers can be illuminated with excitation light through the sides of the chambers (in the plane defined collectively by the sample chambers in the substrate), or more typically, diagonally from above (e.g., at a 45 degree angle), and emitted light is collected from above the chambers (i.e., through the upper walls, in a direction perpendicular to the plane defined by the detection chambers).
  • the upper wall material can exhibit low dispersion of the illuminating light in order to limit Rayleigh scattering.
  • bases can be formed from a material having moderate or low thermal conductivity
  • the film can be formed form a conductive material such that the temperature of the sample chambers can be conveniently controlled by heating or cooling the substrate through the film, regardless of the thermal conductivity of the base.
  • the film can be formed of an adhesive copper-backed tape.
  • the pressure on the film layer applied by the member may be removed at a rate substantially proportional to the application of the pressure exerted by the cam and the volume of the channels that will be reduced due to the adhesive entering the channels. This may allow for accommodation of increased pressure in the sample chambers caused by the sealing operation and provide a defined sample volume in each sample chamber, which may make thermocycling more efficient.
  • a thermocycler may be configured to accommodate two sample substrates, for example, substrates 4810 or 5110 .
  • a perspective view of such a thermocycler 5300 is depicted in FIG. 53A and a partial cross-sectional view is depicted in FIG. 53B .
  • the substrates could be processed at both ends of the thermocycler 5300 (e.g., the left and right sides) shown in FIG. 53A .
  • the thermocycler 5300 may be provided with a heated plate (thermal block) 5350 having a crowned profile and pressure may be applied to the chamber array by providing pressure on the outer edges of the substrate 5310 without transmitting force through the open area (or window) 5305 directly over the sample chambers of the substrates.
  • a relatively thin, narrow heated plate 5350 may be used and transmit sufficient clamping force to the side walls of the substrates rather than through a Peltier device or other component.
  • the membrane may burst due to over-pressurization and/or sample S may leak around the edges of the membrane 2150 , as depicted by the arrow in FIG. 21C .

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Hematology (AREA)
  • Dispersion Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
US11/380,327 2005-04-26 2006-04-26 Systems and Methods for Multiple Analyte Detection Abandoned US20070014695A1 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
PCT/US2006/016060 WO2006116616A2 (fr) 2005-04-26 2006-04-26 Systemes et procedes de detection multiple d'analytes
US11/380,327 US20070014695A1 (en) 2005-04-26 2006-04-26 Systems and Methods for Multiple Analyte Detection
EP06751668.2A EP1885839B1 (fr) 2005-04-26 2006-04-26 Systemes et procedes de detection multiple d'analytes
US12/789,363 US8597590B2 (en) 2005-04-26 2010-05-27 Systems and methods for multiple analyte detection
US14/093,933 US9714444B2 (en) 2005-04-26 2013-12-02 Systems and methods for multiple analyte detection
US15/658,016 US20180016624A1 (en) 2005-04-26 2017-07-24 Systems and Methods for Multiple Analyte Detection

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US67487605P 2005-04-26 2005-04-26
US67475005P 2005-04-26 2005-04-26
US69615705P 2005-06-30 2005-06-30
US11/380,327 US20070014695A1 (en) 2005-04-26 2006-04-26 Systems and Methods for Multiple Analyte Detection

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US12/789,363 Continuation US8597590B2 (en) 2005-04-26 2010-05-27 Systems and methods for multiple analyte detection

Publications (1)

Publication Number Publication Date
US20070014695A1 true US20070014695A1 (en) 2007-01-18

Family

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Family Applications (4)

Application Number Title Priority Date Filing Date
US11/380,327 Abandoned US20070014695A1 (en) 2005-04-26 2006-04-26 Systems and Methods for Multiple Analyte Detection
US12/789,363 Active US8597590B2 (en) 2005-04-26 2010-05-27 Systems and methods for multiple analyte detection
US14/093,933 Active 2026-10-16 US9714444B2 (en) 2005-04-26 2013-12-02 Systems and methods for multiple analyte detection
US15/658,016 Abandoned US20180016624A1 (en) 2005-04-26 2017-07-24 Systems and Methods for Multiple Analyte Detection

Family Applications After (3)

Application Number Title Priority Date Filing Date
US12/789,363 Active US8597590B2 (en) 2005-04-26 2010-05-27 Systems and methods for multiple analyte detection
US14/093,933 Active 2026-10-16 US9714444B2 (en) 2005-04-26 2013-12-02 Systems and methods for multiple analyte detection
US15/658,016 Abandoned US20180016624A1 (en) 2005-04-26 2017-07-24 Systems and Methods for Multiple Analyte Detection

Country Status (3)

Country Link
US (4) US20070014695A1 (fr)
EP (1) EP1885839B1 (fr)
WO (1) WO2006116616A2 (fr)

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US20040179975A1 (en) * 2002-07-26 2004-09-16 Cox David M. Microfluidic device including displaceable material trap, and system
US20050214947A1 (en) * 2004-03-24 2005-09-29 Cox David M Liquid processing device including gas trap, and system and method
US20060029524A1 (en) * 2004-08-05 2006-02-09 3M Innovative Properties Company Sample processing device positioning apparatus and methods
US20060188396A1 (en) * 2000-06-28 2006-08-24 3M Innovative Properties Company Sample processing devices
US20060193752A1 (en) * 2005-02-25 2006-08-31 Levine Leanna M Microvolume flowcell apparatus
US20070053800A1 (en) * 2005-09-02 2007-03-08 Applera Corporation Fluid processing device comprising sample transfer feature
US20070113880A1 (en) * 1997-03-28 2007-05-24 Applera Corporation Thermal cycler for PCR
US20080233634A1 (en) * 2007-03-23 2008-09-25 Jun Okada Nucleic acid detection device
US20090081768A1 (en) * 2007-09-21 2009-03-26 Applera Corporation Devices and Methods for Thermally Isolating Chambers of an Assay Card
US20090162928A1 (en) * 2002-12-19 2009-06-25 3M Innovative Properties Company Integrated sample processing devices
US20090176312A1 (en) * 2007-12-04 2009-07-09 Selinfreund Richard H Biological and chemical test media and system
JP2009300299A (ja) * 2008-06-16 2009-12-24 Toppan Printing Co Ltd 反応チップ処理装置
JP2010022917A (ja) * 2008-07-17 2010-02-04 Toppan Printing Co Ltd 反応容器、反応装置と反応容器の閉塞方法
WO2010012281A1 (fr) 2008-07-29 2010-02-04 Jacques Jonsmann Dispositif microfluidique
WO2010028298A1 (fr) * 2008-09-04 2010-03-11 Sony Dadc Système de diagnostic à l'aide d'un boîtier de prélèvement portable
US20100267161A1 (en) * 2007-09-24 2010-10-21 Bayer Healthcare Llc Multi-Region and Potential Test Sensors, Methods, and Systems
JP2010271304A (ja) * 2009-04-20 2010-12-02 Sony Corp 試料溶液導入キット及び試料溶液注入器
US20110036862A1 (en) * 2007-12-19 2011-02-17 Masaki Kanai Dispensing device
US20110053785A1 (en) * 2000-11-10 2011-03-03 3M Innovative Properties Company Sample processing devices
US20110100823A1 (en) * 2006-04-18 2011-05-05 Advanced Liquid Logic, Inc. Droplet-Based Nucleic Acid Amplification Apparatus and System
US20110190146A1 (en) * 2008-04-28 2011-08-04 President And Fellows Of Harvard College Microfluidic device for storage and well-defined arrangement of droplets
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WO2006116616A2 (fr) 2006-11-02
EP1885839A4 (fr) 2015-05-27
EP1885839A2 (fr) 2008-02-13
WO2006116616A3 (fr) 2007-09-27
US8597590B2 (en) 2013-12-03
US20140162264A1 (en) 2014-06-12
US9714444B2 (en) 2017-07-25
US20110020179A1 (en) 2011-01-27
US20180016624A1 (en) 2018-01-18

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