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US20060118106A1 - Inhaler for powdery, in particular, medical substances - Google Patents

Inhaler for powdery, in particular, medical substances Download PDF

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Publication number
US20060118106A1
US20060118106A1 US10/526,241 US52624105A US2006118106A1 US 20060118106 A1 US20060118106 A1 US 20060118106A1 US 52624105 A US52624105 A US 52624105A US 2006118106 A1 US2006118106 A1 US 2006118106A1
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US
United States
Prior art keywords
inhaler according
spindle
rotary part
dosing chamber
mouthpiece
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US10/526,241
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English (en)
Inventor
Alfred Von Schuckmann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Siegfried Pharma International AG
Sanofi SA
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of US20060118106A1 publication Critical patent/US20060118106A1/en
Priority to US12/098,601 priority Critical patent/US8342174B2/en
Priority to US12/098,612 priority patent/US8342175B2/en
Assigned to SIEGFRIED GENERICS INTERNATIONAL AG reassignment SIEGFRIED GENERICS INTERNATIONAL AG ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: SCHUCKMANN, ALFRED VON
Assigned to SIEGFRIED PHARMA INTERNATIONAL AG reassignment SIEGFRIED PHARMA INTERNATIONAL AG ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: SIEGFRIED GENERICS INTERNATIONAL AG
Assigned to SANOFI SA reassignment SANOFI SA ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: SIEGFRIED PHARMA INTERNATIONAL AG
Priority to US13/685,745 priority patent/US8978646B2/en
Abandoned legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0001—Details of inhalators; Constructional features thereof
    • A61M15/0005—Details of inhalators; Constructional features thereof with means for agitating the medicament
    • A61M15/0006—Details of inhalators; Constructional features thereof with means for agitating the medicament using rotating means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/06—Solids
    • A61M2202/064—Powder

Definitions

  • the invention relates to an inhaler for powdery, in particular medical substances, with a suction air channel leading to a mouthpiece, also a storage chamber for the substance and a linearly moving dosing chamber for apportioning a specific amount of substance from the storage chamber into the region of a transfer point to the suction air stream.
  • An inhaler of this type is known from DE-A 40 27 391.
  • the amount of substance to be discharged is transferred in a downwardly tapering storage chamber to the dosing chamber, which is capable of moving out.
  • the delivery means is a linearly movable slide comprising said dosing chamber. Placed into the channel of the mouthpiece, a rearward space of the dosing chamber docks onto a volume of air stored in a piston/cylinder unit.
  • the inhalation takes place in the sense of a suction air stream, the volume of air is abruptly set free and released.
  • the suction stroke mechanically flow-assisted in this way, clears the dosing chamber in an emptying manner.
  • the expulsion of compressed air triggered by the reduced pressure requires considerable structural complexity; for most patients, it also takes some time and effort to get used to the suddenly occurring surge of air.
  • An object of the invention is to form an inhaler of the generic type in a structurally simple way, such that there is no longer any need to provide an external air stream but nevertheless a complete discharge of a reproducible portion is obtained.
  • the dosing chamber is configured as a transverse bore of a spindle which can be displaced in dependence on a closure cap.
  • the ready-to-discharge position is as it were automatically brought about, simply by the customary handling of closing and opening taking place.
  • the preferably continuous transverse bore can be cleared out from two sides.
  • a particularly effective measure is obtained by a conical transverse bore. The apportioned amount of substance is transferred even more quickly via the component of the suction air stream from the widening end.
  • an air passage adjoining the suction air stream is associated with the dosing chamber. This produces as it were a localized zone of reduced pressure. It is advantageous for an air passage to be respectively provided upstream of each of the two openings of the dosing chamber.
  • an air passage In the case of the conical transverse bore, it is suitable also to provide that associated with the larger clear diameter end of the dosing chamber is an air passage of a smaller diameter than it and associated with the smaller clear diameter end is an air passage of a larger diameter than it.
  • the invention proposes that the air passages are formed on a cup-shaped rotary part guiding the spindle and are in flow communication with air inlets in the lateral wall of a mouthpiece.
  • the corresponding air inlets are disposed on the lateral wall of the inhaler in such a way that they cannot be kept closed either by the user's lips or by the gripping hand holding the stick-shaped body of the inhaler. The risk of them being kept closed is minimized moreover by a number of air inlets that are spaced apart from one another being formed.
  • the air passages are disposed axially offset in relation to the air inlets lying closer to the mouthpiece. This produces an initially contra-acting flow path.
  • the rotary part it proves to be advantageous for the rotary part to form with its cup base the top of the storage chamber, the center of which has a guiding opening for the spindle acting as a plunger slide. In this way, the cup base is given a dual function: indirect or direct cover and guiding hole for the spindle.
  • the spindle which is pointed at the end in the plunging direction in the manner of a screwdriver blade, to be rotationally connected to the rotary part by means of radial fins.
  • the knife-like blade achieved in this way not only brings about an effective rotationally loosening action in the central region but at the same time also helps the spindle to plunge into the mass of powder, and on the other hand it provides welcome support for the spindle with respect to the rotary part, and what is more makes it possible for the alignment of the air passages with the dosing chamber to be retained.
  • the necessary relative linear movement of the spindle and the rotary part in relation to each other is achieved by simple means, in that the cup wall of the cup-shaped rotary part has axial guiding slots in which the fins are guided.
  • This solution is further characterized by an extension limiting stop of the spindle that is provided by the mouthpiece, defining the ready-to-empty position of the dosing chamber, which with its base wall portion provides the transfer point.
  • the closure-cap dependent mounting of the spindle is further characterized by a docking point between the spindle and the closure cap that lies on the mouthpiece side and disengages if overloaded. When the inhaler is closed again, renewed docking between the spindle and the closure cap is conversely obtained.
  • a configuration that is even of independent significance is then embodied by the fact that the rotary part has a rotor with which a stator is associated, with a scooping effect acting so as to carry substance into the dosing chamber when the rotary part is reversed in its rotation.
  • the scoop assembly is formed by web-carried rotor blades extending from an annular disk of the base of the rotary part. Said blades have a lancet- or sickle-shaped outline. Two rotor blades lying diametrically opposite each other are realized.
  • the rotor blades extend substantially on a quarter sector, with a flank directed radially toward the center of the spindle and a blade flank lying approximately at right angles thereto in tangential alignment with the spindle in such a way as to leave a gap. This rules out points of excessive compression.
  • the medical substance adhering for example to a carrier is not rubbed off from it. It is then provided that the flanks lie in a common diametral line.
  • the further structural features are also conducive to the scooping action but do not adversely effect the medicament, in that the rotor engages under the stator in such a way that the stator is formed as a projection protruding radially inward from the inside wall of the storage chamber and extending freely into a rotational path of the rotor.
  • the stator has a trapezoidal outline and is rooted with its base in the inside wall of the storage chamber.
  • the rotational path is axially limited by the underside of the annular disk of the rotary part and the inner side of the rotor blades facing it.
  • a configuration that is advantageous in terms of the association between parts consists in that the stator lies in outline beneath the quarter sector, leaving an interspace between two rotor blades.
  • a sealing bush enclosing the cylindrical portion of the spindle. It may comprise rubber or rubber-like material. Powdery substance deposited on the stem of the spindle is wiped off by the sealing bush. There is no falsification of the dose ready to be discharged.
  • a likewise sealing-related measure of the dispenser mechanism is obtained by a sealing ring inserted with preloading between the inside wall of the storage chamber and the rotary part.
  • rubber or rubber-like material may be used.
  • the sealing ring is snap-fitted in annular grooves of both parts, the annular groove located on the rotary part taking the form of a V-shaped notched groove and the annular groove of the storage chamber, lying at the same height as said notched groove, being of a semicircular form.
  • the said notched groove is involved in the rotational guidance of the rotary part.
  • the closure cap is formed as a screw cap and interacts with the mouthpiece via co-rotating means. The latter are similar to a claw coupling and disengage when there is a separation of the threads.
  • FIG. 1 shows the inhaler according to the invention in a vertical section, enlarged, in the basic position with the cap closed
  • FIG. 2 shows the plan view of this
  • FIG. 3 shows the inhaler in side view
  • FIG. 4 shows the inhaler in section, as in FIG. 1 , but with the closure cap removed and therefore embodying the ready-to-remove position
  • FIG. 5 shows an enlargement taken from FIG. 1 with the spindle in an intermediate position, the dosing chamber extending at the height of the stator
  • FIG. 6 shows the section along the line VI-VI in FIG. 5 .
  • FIG. 7 shows a detailed representation of the rotary part with the rotor and the stator in a perspective view from below, showing the knife-like shape of the lower end of the spindle, and
  • FIG. 8 shows an exploded drawing of the parts forming the inhaler, to be precise in vertical section with respect all the parts, in partial section with regard to the spindle.
  • the inhaler 1 represented in the drawing is realized as a conveniently portable pocket device in the form of a short stick.
  • a stepped, cylindrical housing 2 determines its shape.
  • the cylindrical housing 2 which is like a small tube, passes at the top end of the inhaler 1 into an attached mouthpiece 3 . This is flattened appropriately for a mouth and can be protectively engaged over by means of a cup-shaped closure cap 4 .
  • the closure cap 4 is realized as a screw cap. An internal thread 5 associated with it engages in a corresponding external thread 6 on the lateral wall of the housing 2 . In the region where the mouthpiece 3 is attached, a clip 7 is integrally formed on the closure cap 4 .
  • the end edge of the cup-shaped closure cap 4 butts against an annular shoulder 8 with a stop-limiting and sealing effect, achieved on account of the aforementioned step of the cylindrical housing 2 .
  • the closure cap 4 acts at the same time as an actuating handle 9 for delivering a powdery substance 10 in reproducible portions 10 ′, which substance is accommodated in a storage chamber 11 of the housing 2 in an optionally refillable manner.
  • the dosing device respectively transporting the portion 10 ′ to a transfer point Ü lying outside the storage chamber 11 , is designated as a whole by D.
  • the material that can be dosed it is a medical, powdery substance 10 , for example of the nature that basic substances (lactose) capable of being transported by suction stream act as a vehicle for carrying the micronized fine particles of medicament sticking to their surface.
  • basic substances lactose
  • the suction air channel leading to the mouthpiece 3 has the reference numeral 12 .
  • the lower termination of the storage chamber 11 is formed by a cup-shaped pressure-exerting base 13 . This is under spring loading in the direction of the mouthpiece 3 .
  • the corresponding compression spring has the reference numeral 14 . It is supported by the bottom end winding on a base cap 15 closing the housing 2 there. Said base cap is in latching engagement with the portion of the housing 2 of larger cross-section there.
  • the corresponding latching collar 16 engages in a matching annular groove of the housing 2 .
  • the top end winding of the biased compression spring 14 loads an inner shoulder 17 of a hollow piston 18 of the piston-shaped device 13 / 18 .
  • the stepped cup-shaped pressure-exerting base 13 is connected in a latching manner to the inner shoulder 17 .
  • the cup edge of the pressure-exerting base 13 provides an annular lip 19 , which on account of its rubber-elastic material wipes off the wall of the storage chamber 21 without any substance being lost.
  • a central standing spigot 20 extends from the base cap 15 .
  • Said standing spigot is hollow and, together with the hollow piston 18 , forms a spring chamber 21 for the compression spring 14 .
  • the storage chamber 11 terminates with a cup-shaped rotary part 22 . This forms by its cup base the top 23 of the storage chamber 11 engaging over the housing 2 .
  • a guiding opening 24 is left at the center of the top 23 .
  • This indirectly or directly formed guiding opening 24 receives a spindle 25 , as the key component of the dosing device D.
  • said spindle acts as a linearly moving dosing chamber 26 for the portion 10 ′ to be lifted out, representing a plunger slide. It moves in the longitudinal center axis x-x of the substantially rotationally symmetrically configured inhaler 1 .
  • the spindle 25 forms a point similar to a screwdriver blade. On account of the co-rotation of the spindle 25 , this has a loosening effect on the central region with respect to the mass of powdery substance 10 .
  • the blade 27 virtually resembling a pointed roof, has two mirror-symmetrical oblique flanks and, at the base, adjoins the cylindrical stem of the spindle 25 .
  • the oblique flanks enclose an angle of about 60°.
  • the cylindrical base cross-section of the spindle 25 is retained in the region of the blade 27 (see FIG.
  • the stroke of the linearly moving dosing chamber 26 makes allowance in both end positions of the spindle 25 for the cross-section of the guiding opening 24 to be kept closed with a doctor-blade or wiping-off effect, filling the dosing chamber, over the length of said opening 24 .
  • the end of the closure 4 toward the mouthpiece forms a docking point 28 between the spindle 25 and the closure cap 4 .
  • the latching means on the closure cap is in this case a ring of hooks capable of resilient deflection.
  • Inwardly directed lugs 29 of the resilient tongues of the ring of hooks engage in a narrow waist-like annular groove 30 of the stem 25 .
  • the annular groove 30 continues into a latching head 31 . This can be overcome in both directions by the lugs 29 .
  • the accumulation of material forming the latching head is approximately lenticular.
  • the lugs 29 are realized on a small tube 32 which protrudes into the mouthpiece opening 3 ′ and extends from the inner side of the top of the closure 4 . It is rooted therein.
  • the stem 25 is rotationally connected to the rotary part 22 by means of radial fins 33 formed in the manner of spokes.
  • the fins 33 engage with their free end portions, crossing the suction air channel 12 , in axial guiding slots 34 —three are already sufficient—of the rotary part 22 .
  • the guiding slots 34 distributed at equal angles, are located on the inside of the cup wall 35 of the cup-shaped rotary part 22 .
  • the axial guiding slots 34 are, moreover, of such a length that the powder-drawing plunging stroke of the stem 25 out f a filling plane in the storage chamber 11 to the described transfer point Ü above the top 23 is ensured.
  • the defined ready-to-empty position of the dosing chamber 26 is obtained by an extension limiting stop of the spindle 25 that is provided by the mouthpiece 3 . That is the extreme end of a turned-back wall of the mouthpiece 3 , which in this way keeps the outlet of the guiding slots 34 closed.
  • the mouthpiece 3 acts via a lateral wall 37 in an anchoring manner on the neck of the housing 2 .
  • a latching point 38 is formed between the two parts 2 , 3 . It may be an irreversible latching point 38 .
  • the top 23 of the rotary part 22 is engaged over in a supported manner by an annular shoulder 39 .
  • the dosing chamber 26 is realized as a transverse bore running substantially perpendicularly in relation to the longitudinal center axis x-x. Transferred into the ready-to-empty position, the dosing chamber 26 is in the effective region of the central suction air stream S.
  • An air passage 40 adjoining the suction air channel 12 is associated with the dosing chamber 26 .
  • Said air passage is formed in the cup wall 35 of the rotary part 22 . It comprises radial bores. They extend in the vicinity of the base of the cup-shaped rotary part 22 , that is at the height of, or just above, the upper side of the top 23 .
  • an air passage 40 is provided upstream and at a radial spacing from both open ends of the dosing chamber 26 .
  • One precaution in this connection is that associated with the larger clear diameter end of the dosing chamber 26 formed by a conical transverse bore is an air passage 40 of a smaller diameter than it and associated with the smaller clear diameter end of the dosing chamber 26 is an air passage 40 of a larger diameter than it. This produces a greater reduced pressure with a predominant discharging effect with respect to the administered portion 10 ′ downstream of the air passage 40 of smaller diameter. Nevertheless, the discharge, i.e. emptying of the dosing chamber 26 , takes place from both ends.
  • the passages 40 formed on the cup-shaped rotary part 22 , guiding the stem 25 in a sealed manner, are also in flow communication via a rearward annular space 41 with air inlets 42 which are at a radial distance. These air inlets 42 are also configured as bores and provide the connection to the atmosphere. Said annular space 41 is located between the outer side of the cup wall 35 of the cup-shaped rotary part 22 and the inner side of the lateral wall 37 of the mouthpiece 3 .
  • the air passages 40 are disposed axially offset in relation to the air inlets 42 .
  • the air inlets 42 lie closer to the mouthpiece 3 .
  • the described spatial distancing leads to an initially contra-acting inflow of sucked-in air following on from the main suction air stream S. This and the fact that a component of the suction air stream S lying in the direction in which the dosing chamber 26 extends is built up has the effect that the dosing chamber 26 is completely emptied.
  • the user inhales a precise dose each time.
  • the transfer point Ü is provided here by the base portion of the dosing chamber 26 .
  • the rotary part 22 is used in particular for this purpose, by way of a development. It has a rotor R acting in the upper region of the storage chamber 11 . A stator St is associated with said rotor.
  • annular collar 43 keeps the annular space 41 closed toward the mouthpiece end.
  • Said annular collar extends from the lateral wall of the cup wall 35 and lies with its outer edge against the inner side of the lateral wall 37 of the mouthpiece 3 .
  • FIGS. 1 and 4 reveal, the co-rotation between the mouthpiece 3 and the closure cap 4 , lifting off by an unscrewing action, takes place by a claw coupling 44 between the two.
  • This comprises a longitudinal toothing 45 on the lateral wall 37 of the mouthpiece 3 , which longitudinal toothing engages in corresponding tooth gaps 46 on the inner side of the closure cap 43 .
  • the scoop is formed by two rotor blades 47 . These have a basically sickle-shaped outline.
  • the two rotor blades 47 are located diametrically opposite with respect to the longitudinal center axis x-x of the inhaler 1 . They are mounted on axially running webs 48 spaced at a distance from the center. The webs are rooted in the underside of an arm or an annular disk 49 of the rotary part 22 providing the rotor R.
  • the freely extending rotor blades 47 protruding from he base or the top 23 of the rotary part 22 on the storage chamber side are positioned diametrically opposite in such a way that they are sufficiently spaced apart in the circumferential direction. Geometrically, they substantially take up a quarter sector of the circular cross-section of the storage chamber 11 . Reference should be made to FIG. 6 .
  • the two rotor blades 47 each have a flank 50 aligned radially with the center of the spindle 25 and each have a scoop flank 51 lying at right angles thereto. It runs at a distance from the lateral wall of the spindle 25 in such a way as to leave a gap.
  • the gap has the symbol 52 . In this way, an abrasive effect is avoided.
  • flanks 50 are diametral.
  • the common diametral line of the flanks 50 is designated in FIG. 6 by y-y.
  • the spatially parallel scoop flanks 51 extend perpendicularly in relation to the diametral line y-y and spatially parallel to the axis z-z of the transverse bore of the dosing chamber 26 , which in turn coincides with the axis of the bore of the air passages 40 .
  • the annular disk 49 or two arms in which the rotor blades 47 are rooted continues via an annular wall 53 into the top 23 of the rotary part 22 .
  • FIG. 5 illustrates particularly clearly that the rotor R engages underneath the stator St in such a way that the stator St is formed as a projection protruding radially inward from the inside wall of the storage chamber 11 and extending freely into a rotational path 54 of the rotor R.
  • the rotational path 54 is axially limited by the underside of the annular disk 49 of the rotary part 22 and the inner side of the rotor blades 47 facing it.
  • the axial distance forming the rotational path is significantly greater than the thickness of the stator St, that is the projection, measured in this direction. Therefore, mechanical loads with respect to the frictionally sensitive powdery substance 10 to be discharged do not occur here either.
  • the stator St has a trapezoidal outline. Its arcuate base is rooted in the inside wall of the storage chamber 11 . The base is dimensioned such that the stator St narrowing radially inward in its surface area lies in outline beneath the quarter sector, leaving an interspace 55 between two rotor blades 47 . As FIG. 6 reveals, this at the same time provides an adequate mounting opening for the stator to engage in the rotational path 54 .
  • the radial projection of the stator St in the inward direction is of such a radial length that the plateau of the trapezoid ends before the outer side of the web 48 , likewise forming a gap.
  • FIG. 6 The scooping effect is clear from FIG. 6 if the arrows are observed.
  • Arrow a indicates the direction of reversed rotation of the rotary part 22 .
  • the scoop flanks 51 therefore act as a face pushing the powder lying in front of it.
  • Arrow b shows the approaching scooping-in direction with respect to the end of the dosing chamber 26 having the larger clear diameter.
  • Arrow c indicates the corresponding action at the other rotor blade 47 , that is here also with respect to the scooping action of the scoop flank 51 .
  • the stator St then stands as it were as a fixed chicane in the way of the rotational path 54 .
  • the powdery substance 10 is displaced with a rapidly chamber-filling effect by the scoop flank 51 lying closer to the directing-in flank of the trapezoid, so that, as already stated, consistent filling conditions always occur.
  • the dosing chamber 26 moves in an ascending manner through the zone of the dosing device D in a number of rotations until it has reached with its transfer point Ü the upper side of the top 23 of the cup-shaped rotary part 22 .
  • Said opening is not formed directly by the rotary part 22 , but by a sealing bush 56 lining this passage.
  • Said sealing bush consists of rubber-elastic material and is held by being clipped into the top 23 by latching means 57 . In terms of its plane, it reaches at the top up to the height of the upper side of the annular disk 49 .
  • the groove contour has a centering and rotationally guiding effect.
  • the other annular groove 60 lying at the same height, is located on the inner side of the housing 2 , to be precise in the upper inlet region of the storage chamber 11 .
  • the spindle 25 formed as a lifting spindle, can be varied with respect to the volume of its dosing chamber 26 , i.e. the key component of the dosing device D merely has to be exchanged to achieve a different, precisely reproducible dosing of portions 10 ′.
  • the pressure-exerting base 13 acting in the manner of a piston, is not impaired in its ability to move with respect to the cylinder space, provided by the central portion of the housing 2 , since there the housing has an air-equalizing opening 62 lying to the rear of the annular lip 19 .
  • the cup-shaped pressure-exerting base 13 has a central indentation, directed away from the storage chamber 11 . It is of such a depth on the inside that the end portion of the spindle 25 projecting axially downward beyond the rotor blades 47 in the basic position is accommodated in it.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pulmonology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
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  • Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
  • Medicinal Preparation (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
US10/526,241 2002-09-16 2002-09-16 Inhaler for powdery, in particular, medical substances Abandoned US20060118106A1 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US12/098,601 US8342174B2 (en) 2002-09-16 2008-04-07 Inhaler for powdery substances, in particular medicinal substances
US12/098,612 US8342175B2 (en) 2002-09-16 2008-04-07 Inhaler for powdery substances, in particular medicinal substances
US13/685,745 US8978646B2 (en) 2002-09-16 2012-11-27 Inhaler for powdery substances, in particular medicinal substances

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/EP2002/010353 WO2004033009A1 (fr) 2002-09-16 2002-09-16 Inhalateur pour substances pulverulentes, notamment pour substances medicales

Related Child Applications (2)

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US12/098,601 Division US8342174B2 (en) 2002-09-16 2008-04-07 Inhaler for powdery substances, in particular medicinal substances
US12/098,612 Division US8342175B2 (en) 2002-09-16 2008-04-07 Inhaler for powdery substances, in particular medicinal substances

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US20060118106A1 true US20060118106A1 (en) 2006-06-08

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US10/526,241 Abandoned US20060118106A1 (en) 2002-09-16 2002-09-16 Inhaler for powdery, in particular, medical substances
US12/098,601 Expired - Fee Related US8342174B2 (en) 2002-09-16 2008-04-07 Inhaler for powdery substances, in particular medicinal substances
US12/098,612 Expired - Fee Related US8342175B2 (en) 2002-09-16 2008-04-07 Inhaler for powdery substances, in particular medicinal substances
US13/685,745 Expired - Fee Related US8978646B2 (en) 2002-09-16 2012-11-27 Inhaler for powdery substances, in particular medicinal substances

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US12/098,601 Expired - Fee Related US8342174B2 (en) 2002-09-16 2008-04-07 Inhaler for powdery substances, in particular medicinal substances
US12/098,612 Expired - Fee Related US8342175B2 (en) 2002-09-16 2008-04-07 Inhaler for powdery substances, in particular medicinal substances
US13/685,745 Expired - Fee Related US8978646B2 (en) 2002-09-16 2012-11-27 Inhaler for powdery substances, in particular medicinal substances

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US (4) US20060118106A1 (fr)
EP (3) EP1539286B1 (fr)
JP (1) JP4332502B2 (fr)
AU (1) AU2002368278A1 (fr)
DK (1) DK1539286T3 (fr)
WO (1) WO2004033009A1 (fr)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060289002A1 (en) * 2005-06-24 2006-12-28 Pari Gmbh Spezialisten Fur Effektive Inhalation Inhalation therapy device
US20090050149A1 (en) * 2006-03-10 2009-02-26 Astrazeneca Ab Inhaler for Powdery Substances
US20110232637A1 (en) * 2009-10-02 2011-09-29 Boehringer Ingelheim International Gmbh Powder inhaler
US20120111326A1 (en) * 2008-12-23 2012-05-10 Sanofi Sa Dosing Device for Generating a Gas Flow with an Active Substance Finely Dispersed in the Latter
US8915246B2 (en) 2008-12-30 2014-12-23 Sanofi Sa Dosing device
US20170035977A1 (en) * 2014-04-16 2017-02-09 Sanofi Sa Sealing Member for a Medical Device
WO2018051371A3 (fr) * 2016-09-16 2018-07-26 Cipla Limited Distributeur de poudre

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1905474A3 (fr) 2002-09-16 2008-04-16 von Schuckmann, Alfred Inhalateur pour substances pulvérulentes, en particulier pour substances médicales
US20060118106A1 (en) * 2002-09-16 2006-06-08 Alfred Von Schuckmann Inhaler for powdery, in particular, medical substances
DE102004041524B4 (de) * 2004-08-27 2013-03-21 Sanofi Sa Inhalator für pulverförmige, insbesondere medizinische Substanzen
DE102005033397A1 (de) * 2005-07-18 2007-01-25 Alfred Von Schuckmann Inhalator für pulverförmige, insbesondere medizinische Substanzen
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US20080185000A1 (en) 2008-08-07
EP2497514A3 (fr) 2012-11-07
EP1539286A1 (fr) 2005-06-15
US20080184999A1 (en) 2008-08-07
EP2497513A3 (fr) 2012-10-17
EP1539286B1 (fr) 2015-01-21
AU2002368278A1 (en) 2004-05-04
US20130112199A1 (en) 2013-05-09
DK1539286T3 (en) 2015-04-27
EP2497514B8 (fr) 2015-12-16
EP2497514A2 (fr) 2012-09-12
WO2004033009A1 (fr) 2004-04-22
US8342174B2 (en) 2013-01-01
US8978646B2 (en) 2015-03-17
JP4332502B2 (ja) 2009-09-16
JP2005538816A (ja) 2005-12-22
US8342175B2 (en) 2013-01-01
EP2497514B1 (fr) 2015-10-28
EP2497513B1 (fr) 2015-11-04
EP2497513B8 (fr) 2015-12-16

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