[go: up one dir, main page]

US20050256192A1 - Nutritional composition for enhancing lean muscle stimulus, growth, strength and recovery, creating and prolonging intense muscle pumps, supporting endurance, strength, performance, size and stamina, providing a transducer effect for nitric oxide, increasing nutrient delivery and/or promoting increased vascular response in an individual - Google Patents

Nutritional composition for enhancing lean muscle stimulus, growth, strength and recovery, creating and prolonging intense muscle pumps, supporting endurance, strength, performance, size and stamina, providing a transducer effect for nitric oxide, increasing nutrient delivery and/or promoting increased vascular response in an individual Download PDF

Info

Publication number
US20050256192A1
US20050256192A1 US11/119,168 US11916805A US2005256192A1 US 20050256192 A1 US20050256192 A1 US 20050256192A1 US 11916805 A US11916805 A US 11916805A US 2005256192 A1 US2005256192 A1 US 2005256192A1
Authority
US
United States
Prior art keywords
arginine
nutritional composition
strength
serving
creatine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US11/119,168
Inventor
Paul Gardiner
Marvin Heuer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
PUMP FORMULATIONS Ltd
Original Assignee
PUMP FORMULATIONS Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by PUMP FORMULATIONS Ltd filed Critical PUMP FORMULATIONS Ltd
Priority to US11/119,168 priority Critical patent/US20050256192A1/en
Assigned to PUMP FORMULATIONS LTD. reassignment PUMP FORMULATIONS LTD. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: GARDINER, PAUL T., HEUER, MARVIN A.
Publication of US20050256192A1 publication Critical patent/US20050256192A1/en
Priority to US11/876,390 priority patent/US20080089962A1/en
Priority to US12/291,478 priority patent/US7939113B2/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine

Definitions

  • the present invention relates to a novel nutritional composition which provides for enhancing lean muscle stimulus, growth, strength and recovery, creating and prolonging muscle pumps, supporting endurance, strength, performance, size and stamina, providing a transducer effect for nitric oxide, increasing nutrient delivery and/or promoting increased vascular response, e.g., blood flow and circulation, in an individual, a method for achieving same by consuming the nutritional composition and to a method of manufacturing the nutritional composition.
  • the present invention in accordance with one embodiment thereof, provides for a novel nutritional composition for enhancing lean muscle stimulus, growth, strength and recovery, creating and prolonging muscle pumps, supporting endurance, strength, performance, size and stamina, providing a transducer effect for nitric oxide, increasing nutrient delivery and/or promoting increased vascular response, e.g., blood flow and circulation, in an individual, e.g., a human or animal.
  • the nutritional composition includes ______.
  • the present invention in accordance with one embodiment thereof, also provides, by the ingestion of the novel nutritional composition, a method for enhancing lean muscle stimulus, growth, strength and recovery, creating and prolonging muscle pumps, supporting endurance, strength, performance, size and stamina, providing a transducer effect for nitric oxide, increasing nutrient delivery and/or promoting increased vascular response, e.g., blood flow and circulation, in an individual.
  • the present invention in accordance with one embodiment thereof, provides a method of manufacturing a nutritional composition for enhancing lean muscle stimulus, growth, strength and recovery, creating and prolonging muscle pumps, supporting endurance, strength, performance, size and stamina, providing a transducer effect for nitric oxide, increasing nutrient delivery and/or promoting increased vascular response, e.g., blood flow and circulation, in an individual.
  • the present invention in accordance with one embodiment thereof, provides a timed release delivery system for a novel nutritional composition, the nutritional composition for enhancing lean muscle stimulus, growth, strength and recovery, creating and prolonging muscle pumps, supporting endurance, strength, performance, size and stamina, providing a transducer effect for nitric oxide, increasing nutrient delivery and/or promoting increased vascular response, e.g., blood flow and circulation, in an individual.
  • an effective amount refers to an amount effective for enhancing lean muscle stimulus, growth, strength and recovery, creating and prolonging muscle pumps, supporting endurance, strength, performance, size and stamina, providing a transducer effect for nitric oxide, increasing nutrient delivery and/or promoting increased vascular response, e.g., blood flow and circulation, in an individual when administered over a period of week(s) in accordance with a predetermined dosage regimen, e.g., in accordance with the dosage charts set forth in greater detail below.
  • An effective amount of the nutritional composition is preferably from about 0.1 g to about 20 g of the nutritional composition per serving. More preferably, an effective amount of the composition comprises from about 1 g to about 10 g of the nutritional composition per serving. Most preferably, an effective amount of the composition comprises about 7.5 g of the nutritional composition. In another preferred embodiment of the invention, an effective amount of the composition most preferably comprises about 5.85 g of the nutritional composition.
  • essentially pure preferably refers to a compound that is greater than about 90% pure. More preferably, “essentially pure” refers to a compound that is greater than about 95% pure. Most preferably, “essentially pure” refers to a compound that is greater than about 98% pure.
  • enriched refers to a partially purified extract or composition from which undesirable impurities have been removed.
  • the undesirable impurities may be a single compound or multiple compounds.
  • enriched refers to a composition in which at least 25% of the undesirable impurities have been removed. More preferably, “enriched” refers to a composition in which at least 50% of the undesirable impurities have been removed. Most preferably, “enriched” refers to a composition in which at least 75% of the undesirable impurities have been removed.
  • muscle pump refers to the flow of blood through the veins when muscular contraction compresses the blood veins, which increases the pressure within the veins and exerts pressure on the blood, causing it to flow, thereby acting as a pumping mechanism.
  • One embodiment of the invention provides for a nutritional composition including L-arginine, e.g., L-arginine HCL and/or L-arginine alphaketoglutarate, creatine, L-citrulline, L-aspartic acid, ginseng root extract, and maritime pine (bark) extract.
  • L-arginine e.g., L-arginine HCL and/or L-arginine alphaketoglutarate
  • creatine e.g., L-arginine HCL and/or L-arginine alphaketoglutarate
  • creatine e.g., L-citrulline, L-aspartic acid
  • ginseng root extract ginseng root extract
  • maritime pine (bark) extract maritime pine
  • the present invention in accordance with one embodiment thereof, provides a method of manufacturing such a nutritional composition.
  • the present invention in accordance with one embodiment thereof, provides a timed release delivery system for the novel nutritional composition.
  • This embodiment of the present invention may employ a 5 caplet serving.
  • this embodiment is provided in the dosage form of a drink which may be stored as a powder and reconstituted into a drink at the time of ingestion.
  • the nutritional composition is for use by men.
  • a nutritional composition including about 3.1 g of L-arginine, e.g., about 3.0 g of L-arginine HCL and about 0.1 g of L-arginine alphaketoglutarate, about 1.5 g of creatine malate, about 0.1 g of L-citrulline, about 0.1 g of L-aspartic acid, about 0.05 g of ginseng root extract, and about 2 mg of maritime pine (bark) extract per serving.
  • L-arginine e.g., about 3.0 g of L-arginine HCL and about 0.1 g of L-arginine alphaketoglutarate
  • about 1.5 g of creatine malate about 0.1 g of L-citrulline, about 0.1 g of L-aspartic acid, about 0.05 g of ginseng root extract, and about 2 mg of maritime pine (bark) extract per serving.
  • the present invention in accordance with one embodiment thereof, also provides, by the ingestion of the novel nutritional composition, a method for enhancing lean muscle stimulus, growth, strength and recovery, creating and prolonging muscle pumps, supporting endurance, strength, performance, size and stamina, providing a transducer effect for nitric oxide, increasing nutrient delivery and/or promoting increased vascular response, e.g., blood flow and circulation, in an individual. Furthermore, the present invention, in accordance with one embodiment thereof, provides a method of manufacturing such a nutritional composition. The present invention, in accordance with one embodiment thereof, provides a timed release delivery system for the novel nutritional composition.
  • Another embodiment of the invention provides for a nutritional composition including L-arginine, di-creatine malate, L-arginine alphaketoglutarate, picamilone HCL, asian ginseng powder root extract ( Panax ginseng )L-Citrulline, L-aspartic acid and French maritime pine bark extract.
  • the present invention in accordance with one embodiment thereof, also provides, by the ingestion of the novel nutritional composition, a method for enhancing lean muscle stimulus, growth, strength and recovery, creating and prolonging intense muscle pumps, supporting endurance, strength, performance, size and stamina, providing a transducer effect for nitric oxide, increasing nutrient delivery and/or promoting increased vascular response, e.g., blood flow and circulation, in an individual.
  • the present invention in accordance with one embodiment thereof, provides a method of manufacturing such a nutritional composition.
  • this embodiment is provided in the dosage form of a drink which may be stored as a powder and reconstituted into a drink at the time of ingestion.
  • Examples 7 and 9 set forth below illustrate two examples of such embodiments of the present invention.
  • this embodiment is provided in the dosage form of a caplet.
  • Example 11 set forth below illustrates an example of this embodiment of the present invention.
  • a nutritional composition including about 4.0 g L-arginine, about 1.5 g of di-creatine malate, about 0.1 g of L-arginine alpha ketaglutarate, about 0.1 g of picamilone HCL, about 0.05 g of asian ginseng powder root extract ( Panax ginseng ), about 0.5 g of L-Citrulline, about 0.05 g of L-aspartic acid and about 0.002 g of French maritime pine bark extract per serving.
  • the present invention in accordance with one embodiment thereof, also provides, by the ingestion of the novel nutritional composition, a method for enhancing lean muscle stimulus, growth, strength and recovery, creating and prolonging muscle pumps, supporting endurance, strength, performance, size and stamina, providing a transducer effect for nitric oxide, increasing nutrient delivery and/or promoting increased vascular response, e.g., blood flow and circulation, in an individual. Furthermore, the present invention, in accordance with one embodiment thereof, provides a method of manufacturing such a nutritional composition.
  • Another embodiment of the invention provides for a nutritional composition including L-arginine, e.g., L-arginine HCL and/or L-arginine alphaketoglutarate, creatine hydrates (including but not limited to creatine monohydrate), L-leucine and L-valine.
  • L-arginine e.g., L-arginine HCL and/or L-arginine alphaketoglutarate
  • creatine hydrates including but not limited to creatine monohydrate
  • L-leucine and L-valine L-valine
  • the present invention in accordance with one embodiment thereof, also provides, by the ingestion of the novel nutritional composition, a method for enhancing lean muscle stimulus, growth, strength and recovery, creating and prolonging muscle pumps, supporting endurance, strength, performance, size and stamina, providing a transducer effect for nitric oxide, increasing nutrient delivery and/or promoting increased vascular response, e.g., blood flow and circulation, in an individual.
  • the present invention in accordance with one embodiment thereof, provides a method of manufacturing such a nutritional composition.
  • the present invention in accordance with one embodiment thereof, provides a timed release delivery system for the novel nutritional composition.
  • this embodiment of the present invention employs a 5 caplet serving.
  • a nutritional composition including about 3.0 g of L-arginine, e.g., about 2.9 g of L-arginine HCL and about 0.1 g of L-arginine alphaketoglutarate, about 1.5 g of creatine monohydrate, about 0.1 g of L-valine, and about 0.1 g of L-leucine.
  • the present invention in accordance with one embodiment thereof, also provides, by the ingestion of the novel nutritional composition, a method for enhancing lean muscle stimulus, growth, strength and recovery, creating and prolonging muscle pumps, supporting endurance, strength, performance, size and stamina, providing a transducer effect for nitric oxide, increasing nutrient delivery and/or promoting increased vascular response, e.g., blood flow and circulation, in an individual. Furthermore, the present invention, in accordance with one embodiment thereof, provides a method of manufacturing such a nutritional composition. The present invention, in accordance with one embodiment thereof, provides a timed release delivery system for the novel nutritional composition.
  • Another embodiment of the invention provides for a nutritional composition including L-arginine HCL and L-arginine alpha ketoglutarate, creatine hydrates (including but not limited to creatine monohydrate), L-leucine and L-valine.
  • the present invention in accordance with one embodiment thereof, also provides, by the ingestion of the novel nutritional composition, a method for enhancing lean muscle stimulus, growth, strength and recovery, creating and prolonging muscle pumps, supporting endurance, strength, performance, size and stamina, providing a transducer effect for nitric oxide, increasing nutrient delivery and/or promoting increased vascular response, e.g., blood flow and circulation, in an individual.
  • the present invention in accordance with one embodiment thereof, provides a method of manufacturing such a nutritional composition.
  • the present invention in accordance with one embodiment thereof, provides a timed release delivery system for the novel nutritional composition.
  • this embodiment of the present invention employs a 3 caplet serving.
  • a nutritional composition including about 1.74 g of L-arginine HCL and 0.06 g of L-arginine alpha ketoglutarate, about 0.9 g of creatine monohydrate, about 0.06 g of L-valine, and about 0.06 g of L-leucine.
  • the present invention in accordance with one embodiment thereof, also provides, by the ingestion of the novel nutritional composition, a method for enhancing lean muscle stimulus, growth, strength and recovery, creating and prolonging muscle pumps, supporting endurance, strength, performance, size and stamina, providing a transducer effect for nitric oxide, increasing nutrient delivery and/or promoting increased vascular response, e.g., blood flow and circulation, in an individual.
  • the present invention in accordance with one embodiment thereof, provides a method of manufacturing such a nutritional composition.
  • the present invention in accordance with one embodiment thereof, provides a timed release delivery system for the novel nutritional composition.
  • the nutritional composition of the invention increases blood flow to skeletal muscle by exploiting the mechanisms involved in nitric oxide (NO) production and smooth muscle relaxation. It is believed that the nutritional composition of the invention increases the dilation of blood vessels, which increases the delivery of nutrients and oxygen while assisting the removal of waste byproducts of metabolism. Increasing NO production by consumption of the nutritional composition of the invention results in wider blood vessels, which can carry more blood to muscles. The increased flow of blood results in delivery of nutrients, oxygen and hormones needed for growth and repair and helps remove undesirable byproducts of metabolism that fatigue muscles.
  • NO nitric oxide
  • L-arginine also referred to as (S)-2-Amino-5-[(aminoiminomethyl)amino]pentanoic acid, (CAS Registry No. 74-79-3), is a naturally occurring amino acid.
  • L-arginine also includes derivatives of L-arginine such as esters, and amides, and salts, as well as other derivatives, including derivatives that become active upon metabolism.
  • the structure of L-arginine is as follows:
  • L-arginine is a substrate for NO synthetase and that the ingestion of L-arginine by an animal increases the plasma concentration of L-arginine. It is further believed that increased plasma concentration of L-arginine enhances nitric oxide production by enhancing the concentration of the NO synthetase substrate L-arginine.
  • the nutritional composition of the invention preferably comprises a salt of L-arginine selected from the group consisting of L-arginine hydrochloride and L-arginine alpha-ketoglutarate. More preferably, the nutritional composition of the invention comprises a combination of salts of L-arginine salts comprising L-arginine hydrochloride and L-arginine alpha-ketoglutarate.
  • the nutritional composition of the invention comprises L-arginine hydrochloride and L-arginine alpha-ketoglutarate in a ratio of at least about 10 to 1. More preferably, the nutritional composition of the invention comprises L-arginine hydrochloride and L-arginine alpha-ketoglutarate in a ratio of at least about 20 to 1. Most preferably, the nutritional composition of the invention comprises L-arginine hydrochloride and L-arginine alpha-ketoglutarate in a ratio of about 30 to 1.
  • a serving of the nutritional substrate comprises from about 1 g to about 30 g of an L-arginine salt per serving. More preferably, a serving of the nutritional substrate comprises from about 5 g to about 10 g of an L-arginine salt per serving. In one embodiment, a serving of the nutritional substrate comprises about 3.0 g to about 3.1 g of an L-arginine salt per serving. In another embodiment, a serving of the nutritional substrate comprises about 1.70 to 1.80 g of an L-arginine salt per serving.
  • the nutritional composition of the invention preferably comprises L-arginine base instead of or in addition to a L-arginine salt.
  • this nutritional composition of the invention comprises L-arginine and L-arginine alpha-ketoglutarate in a ratio of at least about 10 to 1. More preferably, this nutritional composition of the invention comprises L-arginine and L-arginine alpha-ketoglutarate in a ratio of at least about 20 to 1. Most preferably, this nutritional composition of the invention comprises L-arginine and L-arginine alpha-ketoglutarate in a ratio of about 40 to 1.
  • a serving of this nutritional substrate comprises from about 1 g to about 30 g of a L-arginine base per serving. More preferably, a serving of this nutritional substrate comprises from about 5 g to about 10 g of an L-arginine base per serving. In one embodiment, a serving of the nutritional substrate comprises about 4.0 g of an L-arginine base per serving.
  • creatine refers to the chemical compound N-methyl-N-guanyl glycine, (CAS Registry No. 57-00-1), also known as, (a-methyl guanido)acetic acid, N-(aminoiminomethyl)-N-glycine, and methylglycocyamine, and Methylguanidoacetic acid, and N-Methyl-N-guanylglycine, whose chemical structure is shown below.
  • Creatine also includes derivatives of creatine such as esters, and amides, and salts, as well as other derivatives, including derivatives that become active upon metabolism.
  • the chemical structure of creatine is as follows:
  • creatine increases strength and muscle size as well as cell volumization.
  • Creatine and creatine derivatives are widely available from a number of commercial sources.
  • Commercially available creatine derivatives include creatine phosphate, creatine citrate, magnesium creatine, alkaline creatine, creatine pyruvate, creatine hydrates (including, but not limited to creatine monohydrate), and creatine malate.
  • Glycocyamine an in vivo precursor of creatine, is also commercially available and suitable in the practice of the present invention.
  • the supplement preferably comprises creatine malate or creatine monohydrate.
  • a serving of the supplement comprises from about 0.1 g to about 10 g of creatine. More preferably, a serving of the supplement comprises from about 0.5 g to about 5 g of creatine. In one embodiment, a serving of the supplement comprises about 1.5 g of creatine. In another embodiment, a serving of the supplement comprises about 0.9 g of creatine.
  • L-citrulline is a naturally occurring amino acid, also known as L-N5-(aminocarbonyl)-Ornithine (CAS Registry No. 372-75-8). As used herein, “L-citrulline” also includes derivatives of L-citrulline such as esters, amides, and salts as well as other derivatives, including derivatives that become active upon metabolism. The chemical structure of L-citrulline is as follows:
  • L-citrulline is a metabolic precursor to L-arginine.
  • L-citrulline increases de novo arginine synthesis thereby increasing the arginine pool. It is hypothesized that ingestion of L-citrulline indirectly supports nitric oxide production by enhancing the plasma concentration of L-arginine substrate for NO synthetase.
  • a serving of the supplement comprises from about 0.01 g to about 10 g of L-citrulline. More preferably, a serving of the supplement comprises from about 0.05 g to about 2 g of L-citrulline. Most preferably, a serving of the supplement comprises about 0.1 g of L-citrulline.
  • L-leucine is a naturally occurring amino acid, also known as (S)-2-amino-4-methylpentanoic acid (CAS Registry No. 61-90-5). As used herein, “L-leucine” also includes derivatives of L-leucine such as esters, amides, and salts as well as other derivatives, including derivatives that become active upon metabolism. The chemical structure of L-leucine is as follows:
  • a serving of the supplement in one embodiment comprises from about 0.01 g to about 10 g of L-leucine. More preferably, a serving of the supplement comprises from about 0.05 g to about 2 g of L-leucine. In one embodiment, a serving of the supplement comprises about 0.1 g of L-leucine. In another embodiment, a serving of the supplement comprises about 0.06 g of L-leucine.
  • L-aspartic acid is a naturally occurring amino acid, also known as (S)-Aminobutanedioic acid (CAS Registry No. 56-84-8). As used herein, “L-aspartic acid” also includes derivatives of L-aspartic acid such as esters, amides, and salts as well as other derivatives, including derivatives that become active upon metabolism. The chemical structure of L-aspartic acid is as follows:
  • a serving of the supplement comprises from about 0.01 g to about 10 g of L-aspartic acid per serving. More preferably, a serving of the supplement comprises from about 0.02 g to about 2 g of L-aspartic acid per serving. Most preferably, a serving of the supplement comprises about 0.05 g of L-aspartic acid per serving.
  • L-valine is a naturally occurring amino acid, also known as (S)-2-amino-3-methylbutanoic acid (CAS Registry No. 72-18-4). As used herein, “L-valine” also includes derivatives of L-valine such as esters, amides, and salts as well as other derivatives, including derivatives that become active upon metabolism.
  • the chemical structure of L-valine is as follows:
  • a serving of the supplement in one embodiment comprises from about 0.01 g to about 10 g of L-valine. More preferably, a serving of the supplement comprises from about 0.05 g to about 2 g of L-valine. In one embodiment, a serving of the supplement comprises about 0.1 g of L-valine. In another embodiment, a serving of the supplement comprises about 0.06 g of L-valine.
  • Ginseng preferably refers to American ginseng ( Panax quinquefolium L.), or Korean Ginseng ( Panax Ginseng ) or Siberian Ginseng (( Eleutherococcus senticosus ) and derivatives thereof. Most preferably Ginseng refers to American Ginseng ( Panax quinquefolium L.), or Korean Ginseng ( Panax Ginseng ) and derivatives thereof.
  • Ginseng stimulates the production of nitric oxide.
  • a serving of the supplement preferably comprises from about 0.001 g to about 0.5 g of American Ginseng or Korean Ginseng per serving. More preferably, a serving of the supplement comprises from about 0.01 g to about 0.1 g of American Ginseng or Korean Ginseng per serving. Most preferably, a serving of the supplement comprises about 0.01 g of Korean Ginseng ( Panax Ginseng ) per serving.
  • French Maritime Pine extract preferably refers to an aqueous extract of the bark of the French maritime pine grown as a mono-species forest, spread over the coastal region of south-west France and preferably comprises a natural blend of genetically programmed constant proportions of bioflavonoids including catechin, epicatechin, taxifolin, monomers, dimers of catechin and epicatechin, oligomeric procyanidnins and phenolic fruit acids such as ferulic acid and caffeic acid. See U.S. Pat. No. 4,698,360, incorporated herein by reference in its entirety.
  • a serving of the supplement comprises from about 0.01 mg to about 20 mg of French maritime pine tree bark extract per serving. More preferably, a serving of the supplement comprises from about 0.1 mg to about 10 mg of French maritime pine tree bark extract per serving. Most preferably, a serving of the supplement comprises about 2 mg of French maritime pine tree bark extract per serving.
  • the nutritional composition may contain a variety of excipients.
  • the present invention in one embodiment, provides for a method for enhancing lean muscle stimulus, growth, strength and recovery, creating and prolonging muscle pumps, supporting endurance, strength, performance, size and stamina, providing a transducer effect for nitric oxide, increasing nutrient delivery and/or promoting increased vascular response, e.g., blood flow and circulation, in an individual, by consuming a nutritional composition that includes L-arginine, creatine, L-aspartic acid, L-citrulline, ginseng root extract and maritime pine (bark) extract.
  • a nutritional composition that includes L-arginine, creatine, L-aspartic acid, L-citrulline, ginseng root extract and maritime pine (bark) extract.
  • the present invention in one embodiment, provides for a nutritional composition including about 3.1 g of L-arginine, e.g., about 3.0 g of L-arginine HCL and about 0.1 g of L-arginine alphaketoglutarate, about 1.5 g of creatine, about 0.1 g of L-aspartic acid, about 0.1 g of L-citrulline, 0.05 g of ginseng root extract and about 2 mg of maritime pine (bark) extract per serving.
  • L-arginine e.g., about 3.0 g of L-arginine HCL and about 0.1 g of L-arginine alphaketoglutarate
  • about 1.5 g of creatine about 0.1 g of L-aspartic acid, about 0.1 g of L-citrulline, 0.05 g of ginseng root extract and about 2 mg of maritime pine (bark) extract per serving.
  • the method also includes a workout to facilitate the process of enhancing lean muscle stimulus, growth, strength and recovery, creating and prolonging muscle pumps, supporting endurance, strength, performance, size and stamina, providing a transducer effect for nitric oxide, increasing nutrient delivery and/or promoting increased vascular response, e.g., blood flow and circulation, in an individual.
  • the nutritional composition is consumed in accordance with the following directions and dosing chart: DIRECTIONS: Based upon a person's bodyweight, take one serving (3 to 5 caplets) with an 8 oz. glass of water, 2 times daily. On days of workout, take 1 of these servings, 30 to 60 minutes before workout. Do not exceed 10 caplets in a 24-hour period.
  • the present invention provides for a method for enhancing lean muscle stimulus, growth, strength and recovery, creating and prolonging muscle pumps, supporting endurance, strength, performance, size and stamina, providing a transducer effect for nitric oxide, increasing nutrient delivery and/or promoting increased vascular response, e.g., blood flow and circulation, in an individual, by consuming a nutritional composition comprising L-arginine, creatine, L-leucine, L-valine.
  • the present invention provides for a nutritional composition including about 3.0 g of L-arginine, e.g., about 2.9 g of L-arginine HCL and about 0.1 g of L-arginine alphaketoglutarate, about 1.5 g of creatine, about 0.1 g of L-leucine and about 0.1 g of L-valine.
  • the method further comprises a workout to facilitate the process of enhancing lean muscle stimulus, growth, strength and recovery, creating and prolonging muscle pumps, supporting endurance, strength, performance, size and stamina, providing a transducer effect for nitric oxide, increasing nutrient delivery and/or promoting increased vascular response, e.g., blood flow and circulation, in an individual.
  • the nutritional composition is consumed in accordance with the following directions and dosing chart: DIRECTIONS FOR MEN AND WOMEN: Based upon a person's gender and bodyweight, take one serving (2 to 5 caplets) with an 8 oz. glass of water, 2 times daily. On days of workout, take 1 of these servings, 30 to 60 minutes before workout. Do not exceed 10 caplets in a 24-hour period. Consume ten 8 fl. oz. glasses of water daily for general good health. Read the entire label before use and follow directions. Minimum Maximum daily serving daily serving (caplets) Second (caplets) Second Gender/lbs First serving Serving First serving Serving Women ⁇ 125 2 2 3 3 Women > 125 3 3 4 4 Men ⁇ 200 3 3 4 4 Men > 200 4 4 5 5
  • the present invention provides for a method for enhancing lean muscle stimulus, growth, strength and recovery, creating and prolonging muscle pumps, supporting endurance, strength, performance, size and stamina, providing a transducer effect for nitric oxide, increasing nutrient delivery and/or promoting increased vascular response, e.g., blood flow and circulation, in an individual, by consuming a nutritional composition comprising L-arginine, creatine, L-leucine, L-valine.
  • the present invention provides for a nutritional composition including about 1.74 g of L-arginine HCL, 0.060 g of L-arginine alpha ketoglutarate, about 0.9 g of creatine, about 0.06 g of L-leucine and about 0.06 g of L-valine.
  • the method further comprises a workout to facilitate the process of enhancing lean muscle stimulus, growth, strength and recovery, creating and prolonging muscle pumps, supporting endurance, strength, performance, size and stamina, providing a transducer effect for nitric oxide, increasing nutrient delivery and/or promoting increased vascular response, e.g., blood flow and circulation, in an individual.
  • the nutritional composition is consumed in accordance with the following directions and dosing chart: DIRECTIONS FOR MEN AND WOMEN: Based upon a person's gender and bodyweight, take one serving (2 to 5 caplets) with an 8 oz. glass of water, 2 times daily. On days of workout, take 1 of these servings, 30 to 60 minutes before workout. Do not exceed 10 caplets in a 24-hour period. Consume ten 8 fl. oz. glasses of water daily for general good health. Read the entire label before use and follow directions. Minimum Maximum daily serving daily serving (caplets) Second (caplets) Second Gender/lbs First serving Serving First serving Serving Women ⁇ 125 2 2 3 3 Women > 125 3 3 4 4 Men ⁇ 200 3 3 4 4 Men > 200 4 4 5 5
  • the present invention also provides for a method of making a nutritional composition that includes the steps of mixing the following ingredients: L-arginine HCL, L-arginine alphaketoglutarate, creatine, L-aspartic acid, L-citrulline, ginseng root extract and maritime pine (bark) extract; and in an additional step, adding the following excipients: potassium chloride, cellulose, dextrose, stearic acid, silica, magnesium stearate, ethyl cellulose, dicalcium phosphate, polyvinyl alcohol, polyethylene glycol, FD&C Red No. 40, talc, and titanium dioxide.
  • the method also includes the step of blending and mixing for 30 minutes.
  • the method includes the steps of checking for uniformity/homogeneity and then aliquoting into a serving.
  • the present invention provides for a method of making a nutritional composition including the steps of mixing the following ingredients: L-arginine HCL, L-arginine alphaketoglutarate, creatine, L-leucine and L-valine; and in an additional step, adding the following excipient: potassium chloride, cellulose, dextrose, stearic acid, silica, magnesium stearate, ethyl cellulose, dicalcium phosphate, polyvinyl alcohol, titanium dioxide, polyethylene glycol, and talc.
  • the method also includes the step of blending and mixing for 30 minutes.
  • the method includes the steps of checking for uniformity/homogeneity and then aliquoting into a serving.
  • the present invention provides for a method of making a nutritional composition including the steps of mixing the following ingredients: L-arginine HCL and L-arginine alpha ketoglutarate, creatine, L-leucine and L-valine; and in an additional step, adding the following excipient: potassium chloride, cellulose, dextrose, stearic acid, silica, magnesium stearate, ethyl cellulose, FD&C Red No. 40, polyvinyl alcohol, polyethylene glycol, talc, and dicalcium phosphate which had been pre-sifted.
  • the method also includes the step of blending and mixing for 30 minutes.
  • the method includes the steps of checking for uniformity/homogeneity and then aliquoting into a serving.
  • the present invention may also provide for a timed release delivery system for a novel nutritional composition for enhancing lean muscle stimulus, growth, strength and recovery, creating and prolonging muscle pumps, supporting endurance, strength, performance, size and stamina, providing a transducer effect for nitric oxide, increasing nutrient delivery and/or promoting increased vascular response, e.g., blood flow and circulation, in an individual, which includes a combination of pharmaceutical grade excipients including Hydroxypropyl Methyl Cellulose (Methocel K100M Premium CR EP-Hypromellose 2208 USP XXII), Ethyl Cellulose (Ethocel Standard FP Premium—NF XVII), and Hydroxypropylcellulose (Klucel LF—NF XVII).
  • a timed release delivery system for a novel nutritional composition for enhancing lean muscle stimulus, growth, strength and recovery, creating and prolonging muscle pumps, supporting endurance, strength, performance, size and stamina, providing a transducer effect for n
  • the present invention may also provide for a timed release delivery system for a novel nutritional composition for enhancing lean muscle stimulus, growth, strength and recovery, creating and prolonging muscle pumps, supporting endurance, strength, performance, size and stamina, providing a transducer effect for nitric oxide, increasing nutrient delivery and/or promoting increased vascular response, e.g., blood flow and circulation, in an individual, which comprises a hydrophilic caplet matrix system comprising water-soluble (i.e., Hydroxypropyl Methyl Cellulose and Hydroxypropylcellulose) and water-insoluble (i.e., Ethyl Cellulose) polymers uniformly incorporated at a specified ratio.
  • a hydrophilic caplet matrix system comprising water-soluble (i.e., Hydroxypropyl Methyl Cellulose and Hydroxypropylcellulose) and water-insoluble (i.e., Ethyl Cellulose) polymers uniformly incorporated at a specified ratio.
  • the novel nutritional composition includes a hydrophilic caplet matrix system which is in the ratio of 1 Hydroxypropylcellulose:1 Ethyl Cellulose:0.5 Hydroxypropyl Methyl Cellulose.
  • a serving of the nutritional supplement for enhancing lean muscle stimulus, growth, strength and recovery, creating and prolonging muscle pumps, supporting endurance, strength, performance, size and stamina, providing a transducer effect for nitric oxide, increasing nutrient delivery and/or promoting increased vascular response, e.g., blood flow and circulation, in an individual, includes the following ingredients in caplet form.
  • the caplet form may contain a coating such as Opadry II.
  • a serving of the nutritional composition for enhancing lean muscle stimulus, growth, strength and recovery, creating and prolonging muscle pumps, supporting endurance, strength, performance, size and stamina, providing a transducer effect for nitric oxide, increasing nutrient delivery and/or promoting increased vascular response, e.g., blood flow and circulation, is preferably consumed in accordance with the following directions and dosing chart:
  • An alternate embodiment of the serving of the nutritional supplement for enhancing lean muscle stimulus, growth, strength and recovery, creating and prolonging muscle pumps, supporting endurance, strength, performance, size and stamina, providing a transducer effect for nitric oxide, increasing nutrient delivery and/or promoting increased vascular response, e.g., blood flow and circulation, in an individual, includes the following ingredients in caplet form.
  • the caplet form may contain a coating such as Opadry II.
  • An alternate embodiment of the serving of the nutritional composition for enhancing lean muscle stimulus, growth, strength and recovery, creating and prolonging muscle pumps, supporting endurance, strength, performance, size and stamina providing a transducer effect for nitric oxide, increasing nutrient delivery and/or promoting increased vascular response, e.g., blood flow and circulation, is preferably consumed in accordance with the following directions and dosing chart: DIRECTIONS FOR MEN AND WOMEN: Based upon a person's gender and bodyweight, take one serving (2 to 5 caplets) with an 8 oz. glass of water, 2 times daily. On days of workout, take 1 of these servings, 30 to 60 minutes before workout. Do not exceed 10 caplets in a 24-hour period. Consume ten 8 fl. oz.
  • the average (n 6) % of labeled amount of arginine dissolved from one caplet of the nutritional supplement for inducing muscle pump and enhancing muscle stimulus and recovery in 900 ml of 0.1N Hydrochloric Acid: Average % of Labeled Amount of Arginine Average Mg of Arginine Time (Minutes) Dissolved ⁇ Std. Dev. Dissolved ⁇ Std. Dev.
  • a serving of the nutritional supplement for enhancing lean muscle stimulus, growth, strength and recovery, creating and prolonging muscle pumps, supporting endurance, strength, performance, size and stamina, providing a transducer effect for nitric oxide, increasing nutrient delivery and/or promoting increased vascular response e.g., blood flow and circulation, in an individual, includes the following ingredients in caplet form.
  • a serving of the nutritional supplement for enhancing lean muscle stimulus, growth, strength and recovery, creating and prolonging muscle pumps, supporting endurance, strength, performance, size and stamina, providing a transducer effect for nitric oxide, increasing nutrient delivery and/or promoting increased vascular response, e.g., blood flow and circulation, in an individual, includes the following ingredients in powder form reconstituted into a drink.
  • Actives % serving (g) Formula % L-arginine 4.0000 68.3527% Di-Creatine Malate 1.5000 25.6323% Creatine 63 0.9450 L-arginine alpha ketaglutarate (2:1) 0.1000 1.7088% Arginine 69 0.0690 Picamilone HCL 0.1000 1.7088% Asian Ginseng Powder root extract 0.0500 0.8544% (Panax ginseng) Ginsenosides (standardized) 25 0.0125 L-Citrulline 0.0500 0.8544% L-aspartic acid 0.0500 0.8544% French Maritime Pine Bark Extract 0.0020 0.0342% Proanthocyanidins Standardized (Pinus 70 0.0014 Maritima) 5.8520 100.00% Other Ingredients g/serving % Dextrose 6.0000 62.9% Citric Acid 2.4600 25.8% SD N&A Bitter Blocker 0.6250 6.5% SD N&A Concord Grape Fla
  • Example 7 One serving of the supplement of Example 7 is consumed by a human, twice daily.
  • a serving of the nutritional composition for enhancing lean muscle stimulus, growth, strength and recovery, creating and prolonging muscle pumps, supporting endurance, strength, performance, size and stamina, providing a transducer effect for nitric oxide, increasing nutrient delivery and/or promoting increased vascular response, e.g., blood flow and circulation, is preferably consumed in powder form reconstituted into a drink.
  • Example 9 One serving of the supplement of Example 9 is consumed by a human, twice daily.
  • a serving of the nutritional composition for enhancing lean muscle stimulus, growth, strength and recovery, creating and prolonging muscle pumps, supporting endurance, strength, performance, size and stamina, providing a transducer effect for nitric oxide, increasing nutrient delivery and/or promoting increased vascular response, e.g., blood flow and circulation, is preferably consumed in caplet form.
  • Example 11 One serving of the supplement of Example 11 is consumed by a human, twice daily, each serving including 5 caplets.

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)

Abstract

A nutritional composition, the consumption of which provides a method for enhancing lean muscle stimulus, growth, strength and recovery, creating and prolonging muscle pumps, supporting endurance, strength, performance, size and stamina, providing a transducer effect for nitric oxide, increasing nutrient delivery and/or promoting increased vascular response in individuals. The nutritional composition may include L-arginine and creatine. In addition, the nutritional composition may also include L-citrulline, L-aspartic acid, ginseng root extract, and maritime pine (bark) extract. Alternatively, the nutritional composition may also include L-leucine and L-valine. A method of manufacturing the nutritional composition is also provided.

Description

    RELATED APPLICATIONS
  • This application is related to U.S. Provisional Patent Application Ser. No. 60/658,782, filed on Mar. 3, 2005, U.S. Provisional Patent Application Ser. No. 60/613,441, filed on Sep. 24, 2004, and U.S. Provisional Patent Application Ser. No. 60/567,127, filed on Apr. 30, 2004, each of which is hereby incorporated by reference in its entirety.
    • FIELD OF THE INVENTION
  • The present invention relates to a novel nutritional composition which provides for enhancing lean muscle stimulus, growth, strength and recovery, creating and prolonging muscle pumps, supporting endurance, strength, performance, size and stamina, providing a transducer effect for nitric oxide, increasing nutrient delivery and/or promoting increased vascular response, e.g., blood flow and circulation, in an individual, a method for achieving same by consuming the nutritional composition and to a method of manufacturing the nutritional composition.
    • SUMMARY OF THE INVENTION
  • The present invention, in accordance with one embodiment thereof, provides for a novel nutritional composition for enhancing lean muscle stimulus, growth, strength and recovery, creating and prolonging muscle pumps, supporting endurance, strength, performance, size and stamina, providing a transducer effect for nitric oxide, increasing nutrient delivery and/or promoting increased vascular response, e.g., blood flow and circulation, in an individual, e.g., a human or animal. In one embodiment, the nutritional composition includes ______.
  • The present invention, in accordance with one embodiment thereof, also provides, by the ingestion of the novel nutritional composition, a method for enhancing lean muscle stimulus, growth, strength and recovery, creating and prolonging muscle pumps, supporting endurance, strength, performance, size and stamina, providing a transducer effect for nitric oxide, increasing nutrient delivery and/or promoting increased vascular response, e.g., blood flow and circulation, in an individual.
  • Furthermore, the present invention, in accordance with one embodiment thereof, provides a method of manufacturing a nutritional composition for enhancing lean muscle stimulus, growth, strength and recovery, creating and prolonging muscle pumps, supporting endurance, strength, performance, size and stamina, providing a transducer effect for nitric oxide, increasing nutrient delivery and/or promoting increased vascular response, e.g., blood flow and circulation, in an individual.
  • Still further, the present invention, in accordance with one embodiment thereof, provides a timed release delivery system for a novel nutritional composition, the nutritional composition for enhancing lean muscle stimulus, growth, strength and recovery, creating and prolonging muscle pumps, supporting endurance, strength, performance, size and stamina, providing a transducer effect for nitric oxide, increasing nutrient delivery and/or promoting increased vascular response, e.g., blood flow and circulation, in an individual.
    • DETAILED DESCRIPTION OF THE INVENTION Definitions
  • As used herein, “an effective amount” refers to an amount effective for enhancing lean muscle stimulus, growth, strength and recovery, creating and prolonging muscle pumps, supporting endurance, strength, performance, size and stamina, providing a transducer effect for nitric oxide, increasing nutrient delivery and/or promoting increased vascular response, e.g., blood flow and circulation, in an individual when administered over a period of week(s) in accordance with a predetermined dosage regimen, e.g., in accordance with the dosage charts set forth in greater detail below. An effective amount of the nutritional composition is preferably from about 0.1 g to about 20 g of the nutritional composition per serving. More preferably, an effective amount of the composition comprises from about 1 g to about 10 g of the nutritional composition per serving. Most preferably, an effective amount of the composition comprises about 7.5 g of the nutritional composition. In another preferred embodiment of the invention, an effective amount of the composition most preferably comprises about 5.85 g of the nutritional composition.
  • As used herein, “essentially pure” preferably refers to a compound that is greater than about 90% pure. More preferably, “essentially pure” refers to a compound that is greater than about 95% pure. Most preferably, “essentially pure” refers to a compound that is greater than about 98% pure.
  • As used herein, “enriched” refers to a partially purified extract or composition from which undesirable impurities have been removed. The undesirable impurities may be a single compound or multiple compounds. Preferably, “enriched” refers to a composition in which at least 25% of the undesirable impurities have been removed. More preferably, “enriched” refers to a composition in which at least 50% of the undesirable impurities have been removed. Most preferably, “enriched” refers to a composition in which at least 75% of the undesirable impurities have been removed.
  • As used herein, “muscle pump” refers to the flow of blood through the veins when muscular contraction compresses the blood veins, which increases the pressure within the veins and exerts pressure on the blood, causing it to flow, thereby acting as a pumping mechanism.
  • One embodiment of the invention provides for a nutritional composition including L-arginine, e.g., L-arginine HCL and/or L-arginine alphaketoglutarate, creatine, L-citrulline, L-aspartic acid, ginseng root extract, and maritime pine (bark) extract. The present invention, in accordance with one embodiment thereof, also provides, by the ingestion of the novel nutritional composition, a method for enhancing lean muscle stimulus, growth, strength and recovery, creating and prolonging muscle pumps, supporting endurance, strength, performance, size and stamina, providing a transducer effect for nitric oxide, increasing nutrient delivery and/or promoting increased vascular response, e.g., blood flow and circulation, in an individual. Furthermore, the present invention, in accordance with one embodiment thereof, provides a method of manufacturing such a nutritional composition. The present invention, in accordance with one embodiment thereof, provides a timed release delivery system for the novel nutritional composition. This embodiment of the present invention may employ a 5 caplet serving. Preferably, this embodiment is provided in the dosage form of a drink which may be stored as a powder and reconstituted into a drink at the time of ingestion. In one embodiment, the nutritional composition is for use by men.
  • For instance, in one such embodiment of the invention there is provided for a nutritional composition including about 3.1 g of L-arginine, e.g., about 3.0 g of L-arginine HCL and about 0.1 g of L-arginine alphaketoglutarate, about 1.5 g of creatine malate, about 0.1 g of L-citrulline, about 0.1 g of L-aspartic acid, about 0.05 g of ginseng root extract, and about 2 mg of maritime pine (bark) extract per serving. The present invention, in accordance with one embodiment thereof, also provides, by the ingestion of the novel nutritional composition, a method for enhancing lean muscle stimulus, growth, strength and recovery, creating and prolonging muscle pumps, supporting endurance, strength, performance, size and stamina, providing a transducer effect for nitric oxide, increasing nutrient delivery and/or promoting increased vascular response, e.g., blood flow and circulation, in an individual. Furthermore, the present invention, in accordance with one embodiment thereof, provides a method of manufacturing such a nutritional composition. The present invention, in accordance with one embodiment thereof, provides a timed release delivery system for the novel nutritional composition.
  • Another embodiment of the invention provides for a nutritional composition including L-arginine, di-creatine malate, L-arginine alphaketoglutarate, picamilone HCL, asian ginseng powder root extract (Panax ginseng)L-Citrulline, L-aspartic acid and French maritime pine bark extract. The present invention, in accordance with one embodiment thereof, also provides, by the ingestion of the novel nutritional composition, a method for enhancing lean muscle stimulus, growth, strength and recovery, creating and prolonging intense muscle pumps, supporting endurance, strength, performance, size and stamina, providing a transducer effect for nitric oxide, increasing nutrient delivery and/or promoting increased vascular response, e.g., blood flow and circulation, in an individual. Furthermore, the present invention, in accordance with one embodiment thereof, provides a method of manufacturing such a nutritional composition. Preferably, this embodiment is provided in the dosage form of a drink which may be stored as a powder and reconstituted into a drink at the time of ingestion. Examples 7 and 9 set forth below illustrate two examples of such embodiments of the present invention. Alternatively, this embodiment is provided in the dosage form of a caplet. Example 11 set forth below illustrates an example of this embodiment of the present invention.
  • For instance, in one such embodiment of the invention there is provided for a nutritional composition including about 4.0 g L-arginine, about 1.5 g of di-creatine malate, about 0.1 g of L-arginine alpha ketaglutarate, about 0.1 g of picamilone HCL, about 0.05 g of asian ginseng powder root extract (Panax ginseng), about 0.5 g of L-Citrulline, about 0.05 g of L-aspartic acid and about 0.002 g of French maritime pine bark extract per serving. The present invention, in accordance with one embodiment thereof, also provides, by the ingestion of the novel nutritional composition, a method for enhancing lean muscle stimulus, growth, strength and recovery, creating and prolonging muscle pumps, supporting endurance, strength, performance, size and stamina, providing a transducer effect for nitric oxide, increasing nutrient delivery and/or promoting increased vascular response, e.g., blood flow and circulation, in an individual. Furthermore, the present invention, in accordance with one embodiment thereof, provides a method of manufacturing such a nutritional composition.
  • Another embodiment of the invention provides for a nutritional composition including L-arginine, e.g., L-arginine HCL and/or L-arginine alphaketoglutarate, creatine hydrates (including but not limited to creatine monohydrate), L-leucine and L-valine. The present invention, in accordance with one embodiment thereof, also provides, by the ingestion of the novel nutritional composition, a method for enhancing lean muscle stimulus, growth, strength and recovery, creating and prolonging muscle pumps, supporting endurance, strength, performance, size and stamina, providing a transducer effect for nitric oxide, increasing nutrient delivery and/or promoting increased vascular response, e.g., blood flow and circulation, in an individual. Furthermore, the present invention, in accordance with one embodiment thereof, provides a method of manufacturing such a nutritional composition. The present invention, in accordance with one embodiment thereof, provides a timed release delivery system for the novel nutritional composition. Advantageously, this embodiment of the present invention employs a 5 caplet serving.
  • For instance, in one such embodiment of the invention there is provided for a nutritional composition including about 3.0 g of L-arginine, e.g., about 2.9 g of L-arginine HCL and about 0.1 g of L-arginine alphaketoglutarate, about 1.5 g of creatine monohydrate, about 0.1 g of L-valine, and about 0.1 g of L-leucine. The present invention, in accordance with one embodiment thereof, also provides, by the ingestion of the novel nutritional composition, a method for enhancing lean muscle stimulus, growth, strength and recovery, creating and prolonging muscle pumps, supporting endurance, strength, performance, size and stamina, providing a transducer effect for nitric oxide, increasing nutrient delivery and/or promoting increased vascular response, e.g., blood flow and circulation, in an individual. Furthermore, the present invention, in accordance with one embodiment thereof, provides a method of manufacturing such a nutritional composition. The present invention, in accordance with one embodiment thereof, provides a timed release delivery system for the novel nutritional composition.
  • Another embodiment of the invention provides for a nutritional composition including L-arginine HCL and L-arginine alpha ketoglutarate, creatine hydrates (including but not limited to creatine monohydrate), L-leucine and L-valine. The present invention, in accordance with one embodiment thereof, also provides, by the ingestion of the novel nutritional composition, a method for enhancing lean muscle stimulus, growth, strength and recovery, creating and prolonging muscle pumps, supporting endurance, strength, performance, size and stamina, providing a transducer effect for nitric oxide, increasing nutrient delivery and/or promoting increased vascular response, e.g., blood flow and circulation, in an individual. Furthermore, the present invention, in accordance with one embodiment thereof, provides a method of manufacturing such a nutritional composition. The present invention, in accordance with one embodiment thereof, provides a timed release delivery system for the novel nutritional composition. Advantageously, this embodiment of the present invention employs a 3 caplet serving.
  • For instance, in one such embodiment of the invention there is provided for a nutritional composition including about 1.74 g of L-arginine HCL and 0.06 g of L-arginine alpha ketoglutarate, about 0.9 g of creatine monohydrate, about 0.06 g of L-valine, and about 0.06 g of L-leucine. The present invention, in accordance with one embodiment thereof, also provides, by the ingestion of the novel nutritional composition, a method for enhancing lean muscle stimulus, growth, strength and recovery, creating and prolonging muscle pumps, supporting endurance, strength, performance, size and stamina, providing a transducer effect for nitric oxide, increasing nutrient delivery and/or promoting increased vascular response, e.g., blood flow and circulation, in an individual. Furthermore, the present invention, in accordance with one embodiment thereof, provides a method of manufacturing such a nutritional composition. The present invention, in accordance with one embodiment thereof, provides a timed release delivery system for the novel nutritional composition.
  • While not wishing to be bound by theory it is believed that the nutritional composition of the invention increases blood flow to skeletal muscle by exploiting the mechanisms involved in nitric oxide (NO) production and smooth muscle relaxation. It is believed that the nutritional composition of the invention increases the dilation of blood vessels, which increases the delivery of nutrients and oxygen while assisting the removal of waste byproducts of metabolism. Increasing NO production by consumption of the nutritional composition of the invention results in wider blood vessels, which can carry more blood to muscles. The increased flow of blood results in delivery of nutrients, oxygen and hormones needed for growth and repair and helps remove undesirable byproducts of metabolism that fatigue muscles.
  • L-arginine
  • L-arginine, also referred to as (S)-2-Amino-5-[(aminoiminomethyl)amino]pentanoic acid, (CAS Registry No. 74-79-3), is a naturally occurring amino acid. As used herein, “L-arginine” also includes derivatives of L-arginine such as esters, and amides, and salts, as well as other derivatives, including derivatives that become active upon metabolism. The structure of L-arginine is as follows:
    Figure US20050256192A1-20051117-C00001
  • While not being bound by theory it is believed that L-arginine is a substrate for NO synthetase and that the ingestion of L-arginine by an animal increases the plasma concentration of L-arginine. It is further believed that increased plasma concentration of L-arginine enhances nitric oxide production by enhancing the concentration of the NO synthetase substrate L-arginine.
  • The nutritional composition of the invention preferably comprises a salt of L-arginine selected from the group consisting of L-arginine hydrochloride and L-arginine alpha-ketoglutarate. More preferably, the nutritional composition of the invention comprises a combination of salts of L-arginine salts comprising L-arginine hydrochloride and L-arginine alpha-ketoglutarate.
  • Preferably, the nutritional composition of the invention comprises L-arginine hydrochloride and L-arginine alpha-ketoglutarate in a ratio of at least about 10 to 1. More preferably, the nutritional composition of the invention comprises L-arginine hydrochloride and L-arginine alpha-ketoglutarate in a ratio of at least about 20 to 1. Most preferably, the nutritional composition of the invention comprises L-arginine hydrochloride and L-arginine alpha-ketoglutarate in a ratio of about 30 to 1.
  • Preferably, a serving of the nutritional substrate comprises from about 1 g to about 30 g of an L-arginine salt per serving. More preferably, a serving of the nutritional substrate comprises from about 5 g to about 10 g of an L-arginine salt per serving. In one embodiment, a serving of the nutritional substrate comprises about 3.0 g to about 3.1 g of an L-arginine salt per serving. In another embodiment, a serving of the nutritional substrate comprises about 1.70 to 1.80 g of an L-arginine salt per serving.
  • In another preferred embodiment, the nutritional composition of the invention preferably comprises L-arginine base instead of or in addition to a L-arginine salt. Preferably, this nutritional composition of the invention comprises L-arginine and L-arginine alpha-ketoglutarate in a ratio of at least about 10 to 1. More preferably, this nutritional composition of the invention comprises L-arginine and L-arginine alpha-ketoglutarate in a ratio of at least about 20 to 1. Most preferably, this nutritional composition of the invention comprises L-arginine and L-arginine alpha-ketoglutarate in a ratio of about 40 to 1.
  • Preferably, a serving of this nutritional substrate comprises from about 1 g to about 30 g of a L-arginine base per serving. More preferably, a serving of this nutritional substrate comprises from about 5 g to about 10 g of an L-arginine base per serving. In one embodiment, a serving of the nutritional substrate comprises about 4.0 g of an L-arginine base per serving.
  • Creatine
  • As used herein, “creatine” refers to the chemical compound N-methyl-N-guanyl glycine, (CAS Registry No. 57-00-1), also known as, (a-methyl guanido)acetic acid, N-(aminoiminomethyl)-N-glycine, and methylglycocyamine, and Methylguanidoacetic acid, and N-Methyl-N-guanylglycine, whose chemical structure is shown below. As used herein, “creatine” also includes derivatives of creatine such as esters, and amides, and salts, as well as other derivatives, including derivatives that become active upon metabolism. The chemical structure of creatine is as follows:
    Figure US20050256192A1-20051117-C00002
  • While not wishing to be bound by theory it is believed that creatine increases strength and muscle size as well as cell volumization.
  • Creatine and creatine derivatives are widely available from a number of commercial sources. Commercially available creatine derivatives include creatine phosphate, creatine citrate, magnesium creatine, alkaline creatine, creatine pyruvate, creatine hydrates (including, but not limited to creatine monohydrate), and creatine malate. Glycocyamine, an in vivo precursor of creatine, is also commercially available and suitable in the practice of the present invention. The supplement preferably comprises creatine malate or creatine monohydrate.
  • As used herein, a serving of the supplement comprises from about 0.1 g to about 10 g of creatine. More preferably, a serving of the supplement comprises from about 0.5 g to about 5 g of creatine. In one embodiment, a serving of the supplement comprises about 1.5 g of creatine. In another embodiment, a serving of the supplement comprises about 0.9 g of creatine.
  • L-citrulline
  • “L-citrulline” is a naturally occurring amino acid, also known as L-N5-(aminocarbonyl)-Ornithine (CAS Registry No. 372-75-8). As used herein, “L-citrulline” also includes derivatives of L-citrulline such as esters, amides, and salts as well as other derivatives, including derivatives that become active upon metabolism. The chemical structure of L-citrulline is as follows:
    Figure US20050256192A1-20051117-C00003
  • While not being bound by theory, it is believed that L-citrulline is a metabolic precursor to L-arginine. Thus, L-citrulline increases de novo arginine synthesis thereby increasing the arginine pool. It is hypothesized that ingestion of L-citrulline indirectly supports nitric oxide production by enhancing the plasma concentration of L-arginine substrate for NO synthetase.
  • As used herein, a serving of the supplement comprises from about 0.01 g to about 10 g of L-citrulline. More preferably, a serving of the supplement comprises from about 0.05 g to about 2 g of L-citrulline. Most preferably, a serving of the supplement comprises about 0.1 g of L-citrulline.
  • L-leucine
  • “L-leucine” is a naturally occurring amino acid, also known as (S)-2-amino-4-methylpentanoic acid (CAS Registry No. 61-90-5). As used herein, “L-leucine” also includes derivatives of L-leucine such as esters, amides, and salts as well as other derivatives, including derivatives that become active upon metabolism. The chemical structure of L-leucine is as follows:
    Figure US20050256192A1-20051117-C00004
  • As used herein, a serving of the supplement in one embodiment comprises from about 0.01 g to about 10 g of L-leucine. More preferably, a serving of the supplement comprises from about 0.05 g to about 2 g of L-leucine. In one embodiment, a serving of the supplement comprises about 0.1 g of L-leucine. In another embodiment, a serving of the supplement comprises about 0.06 g of L-leucine.
  • L-aspartic Acid
  • “L-aspartic acid” is a naturally occurring amino acid, also known as (S)-Aminobutanedioic acid (CAS Registry No. 56-84-8). As used herein, “L-aspartic acid” also includes derivatives of L-aspartic acid such as esters, amides, and salts as well as other derivatives, including derivatives that become active upon metabolism. The chemical structure of L-aspartic acid is as follows:
    Figure US20050256192A1-20051117-C00005
  • While not being bound by theory it is believed that aspartic acid facilitates the production of nitric oxide.
  • As used herein, a serving of the supplement comprises from about 0.01 g to about 10 g of L-aspartic acid per serving. More preferably, a serving of the supplement comprises from about 0.02 g to about 2 g of L-aspartic acid per serving. Most preferably, a serving of the supplement comprises about 0.05 g of L-aspartic acid per serving.
  • L-valine
  • “L-valine” is a naturally occurring amino acid, also known as (S)-2-amino-3-methylbutanoic acid (CAS Registry No. 72-18-4). As used herein, “L-valine” also includes derivatives of L-valine such as esters, amides, and salts as well as other derivatives, including derivatives that become active upon metabolism. The chemical structure of L-valine is as follows:
    Figure US20050256192A1-20051117-C00006
  • As used herein, a serving of the supplement in one embodiment comprises from about 0.01 g to about 10 g of L-valine. More preferably, a serving of the supplement comprises from about 0.05 g to about 2 g of L-valine. In one embodiment, a serving of the supplement comprises about 0.1 g of L-valine. In another embodiment, a serving of the supplement comprises about 0.06 g of L-valine.
  • Ginseng
  • As used herein Ginseng preferably refers to American ginseng (Panax quinquefolium L.), or Korean Ginseng (Panax Ginseng) or Siberian Ginseng ((Eleutherococcus senticosus) and derivatives thereof. Most preferably Ginseng refers to American Ginseng (Panax quinquefolium L.), or Korean Ginseng (Panax Ginseng) and derivatives thereof.
  • While not being bound by theory it is believed that Ginseng stimulates the production of nitric oxide.
  • As used herein, a serving of the supplement preferably comprises from about 0.001 g to about 0.5 g of American Ginseng or Korean Ginseng per serving. More preferably, a serving of the supplement comprises from about 0.01 g to about 0.1 g of American Ginseng or Korean Ginseng per serving. Most preferably, a serving of the supplement comprises about 0.01 g of Korean Ginseng (Panax Ginseng) per serving.
  • French Maritime Pine Extract
  • French Maritime Pine extract preferably refers to an aqueous extract of the bark of the French maritime pine grown as a mono-species forest, spread over the coastal region of south-west France and preferably comprises a natural blend of genetically programmed constant proportions of bioflavonoids including catechin, epicatechin, taxifolin, monomers, dimers of catechin and epicatechin, oligomeric procyanidnins and phenolic fruit acids such as ferulic acid and caffeic acid. See U.S. Pat. No. 4,698,360, incorporated herein by reference in its entirety.
  • While not being bound by theory it is believed that the extract from the bark of French maritime pine tree supports circulation by preventing constriction of arteries and blood clotting.
  • As used herein, a serving of the supplement comprises from about 0.01 mg to about 20 mg of French maritime pine tree bark extract per serving. More preferably, a serving of the supplement comprises from about 0.1 mg to about 10 mg of French maritime pine tree bark extract per serving. Most preferably, a serving of the supplement comprises about 2 mg of French maritime pine tree bark extract per serving.
  • Those of skill in the art will appreciate that the nutritional composition may contain a variety of excipients.
  • As set forth above, the present invention, in one embodiment, provides for a method for enhancing lean muscle stimulus, growth, strength and recovery, creating and prolonging muscle pumps, supporting endurance, strength, performance, size and stamina, providing a transducer effect for nitric oxide, increasing nutrient delivery and/or promoting increased vascular response, e.g., blood flow and circulation, in an individual, by consuming a nutritional composition that includes L-arginine, creatine, L-aspartic acid, L-citrulline, ginseng root extract and maritime pine (bark) extract. For instance, the present invention, in one embodiment, provides for a nutritional composition including about 3.1 g of L-arginine, e.g., about 3.0 g of L-arginine HCL and about 0.1 g of L-arginine alphaketoglutarate, about 1.5 g of creatine, about 0.1 g of L-aspartic acid, about 0.1 g of L-citrulline, 0.05 g of ginseng root extract and about 2 mg of maritime pine (bark) extract per serving. Advantageously, the method also includes a workout to facilitate the process of enhancing lean muscle stimulus, growth, strength and recovery, creating and prolonging muscle pumps, supporting endurance, strength, performance, size and stamina, providing a transducer effect for nitric oxide, increasing nutrient delivery and/or promoting increased vascular response, e.g., blood flow and circulation, in an individual. Preferably, the nutritional composition is consumed in accordance with the following directions and dosing chart:
    DIRECTIONS: Based upon a person's bodyweight, take one serving
    (3 to 5 caplets) with an 8 oz. glass of water, 2 times daily. On days of
    workout, take 1 of these servings, 30 to 60 minutes before workout.
    Do not exceed 10 caplets in a 24-hour period. Consume ten 8 oz.
    glasses of water daily for general good health. Read the entire
    label before use and follow directions.
    Minimum Maximum
    daily serving daily serving
    (caplets) Second (caplets) Second
    First serving Serving First serving Serving
    Men < 200 lbs 3 3 4 4
    Men > 200 lbs 4 4 5 5
  • In an alternate embodiment, the present invention provides for a method for enhancing lean muscle stimulus, growth, strength and recovery, creating and prolonging muscle pumps, supporting endurance, strength, performance, size and stamina, providing a transducer effect for nitric oxide, increasing nutrient delivery and/or promoting increased vascular response, e.g., blood flow and circulation, in an individual, by consuming a nutritional composition comprising L-arginine, creatine, L-leucine, L-valine. For instance, in one embodiment, the present invention provides for a nutritional composition including about 3.0 g of L-arginine, e.g., about 2.9 g of L-arginine HCL and about 0.1 g of L-arginine alphaketoglutarate, about 1.5 g of creatine, about 0.1 g of L-leucine and about 0.1 g of L-valine. Advantageously, the method further comprises a workout to facilitate the process of enhancing lean muscle stimulus, growth, strength and recovery, creating and prolonging muscle pumps, supporting endurance, strength, performance, size and stamina, providing a transducer effect for nitric oxide, increasing nutrient delivery and/or promoting increased vascular response, e.g., blood flow and circulation, in an individual. Preferably, the nutritional composition is consumed in accordance with the following directions and dosing chart:
    DIRECTIONS FOR MEN AND WOMEN: Based upon a person's
    gender and bodyweight, take one serving (2 to 5 caplets) with an
    8 oz. glass of water, 2 times daily. On days of workout, take 1 of
    these servings, 30 to 60 minutes before workout. Do not exceed
    10 caplets in a 24-hour period. Consume ten 8 fl. oz. glasses of
    water daily for general good health. Read the entire label before
    use and follow directions.
    Minimum Maximum
    daily serving daily serving
    (caplets) Second (caplets) Second
    Gender/lbs First serving Serving First serving Serving
    Women < 125 2 2 3 3
    Women > 125 3 3 4 4
    Men < 200 3 3 4 4
    Men > 200 4 4 5 5
  • In an alternate embodiment, the present invention provides for a method for enhancing lean muscle stimulus, growth, strength and recovery, creating and prolonging muscle pumps, supporting endurance, strength, performance, size and stamina, providing a transducer effect for nitric oxide, increasing nutrient delivery and/or promoting increased vascular response, e.g., blood flow and circulation, in an individual, by consuming a nutritional composition comprising L-arginine, creatine, L-leucine, L-valine. For instance, in one embodiment, the present invention provides for a nutritional composition including about 1.74 g of L-arginine HCL, 0.060 g of L-arginine alpha ketoglutarate, about 0.9 g of creatine, about 0.06 g of L-leucine and about 0.06 g of L-valine. Advantageously, the method further comprises a workout to facilitate the process of enhancing lean muscle stimulus, growth, strength and recovery, creating and prolonging muscle pumps, supporting endurance, strength, performance, size and stamina, providing a transducer effect for nitric oxide, increasing nutrient delivery and/or promoting increased vascular response, e.g., blood flow and circulation, in an individual. Preferably, the nutritional composition is consumed in accordance with the following directions and dosing chart:
    DIRECTIONS FOR MEN AND WOMEN: Based upon a person's
    gender and bodyweight, take one serving (2 to 5 caplets) with an 8
    oz. glass of water, 2 times daily. On days of workout, take 1 of these
    servings, 30 to 60 minutes before workout. Do not exceed 10 caplets
    in a 24-hour period. Consume ten 8 fl. oz. glasses of water daily for
    general good health. Read the entire label before use and follow
    directions.
    Minimum Maximum
    daily serving daily serving
    (caplets) Second (caplets) Second
    Gender/lbs First serving Serving First serving Serving
    Women < 125 2 2 3 3
    Women > 125 3 3 4 4
    Men < 200 3 3 4 4
    Men > 200 4 4 5 5
  • In one embodiment, the present invention also provides for a method of making a nutritional composition that includes the steps of mixing the following ingredients: L-arginine HCL, L-arginine alphaketoglutarate, creatine, L-aspartic acid, L-citrulline, ginseng root extract and maritime pine (bark) extract; and in an additional step, adding the following excipients: potassium chloride, cellulose, dextrose, stearic acid, silica, magnesium stearate, ethyl cellulose, dicalcium phosphate, polyvinyl alcohol, polyethylene glycol, FD&C Red No. 40, talc, and titanium dioxide. The method also includes the step of blending and mixing for 30 minutes. Finally, the method includes the steps of checking for uniformity/homogeneity and then aliquoting into a serving.
  • In addition, the present invention provides for a method of making a nutritional composition including the steps of mixing the following ingredients: L-arginine HCL, L-arginine alphaketoglutarate, creatine, L-leucine and L-valine; and in an additional step, adding the following excipient: potassium chloride, cellulose, dextrose, stearic acid, silica, magnesium stearate, ethyl cellulose, dicalcium phosphate, polyvinyl alcohol, titanium dioxide, polyethylene glycol, and talc. The method also includes the step of blending and mixing for 30 minutes. Finally, the method includes the steps of checking for uniformity/homogeneity and then aliquoting into a serving.
  • In addition, the present invention provides for a method of making a nutritional composition including the steps of mixing the following ingredients: L-arginine HCL and L-arginine alpha ketoglutarate, creatine, L-leucine and L-valine; and in an additional step, adding the following excipient: potassium chloride, cellulose, dextrose, stearic acid, silica, magnesium stearate, ethyl cellulose, FD&C Red No. 40, polyvinyl alcohol, polyethylene glycol, talc, and dicalcium phosphate which had been pre-sifted. The method also includes the step of blending and mixing for 30 minutes. Finally, the method includes the steps of checking for uniformity/homogeneity and then aliquoting into a serving.
  • According to various embodiments, the present invention may also provide for a timed release delivery system for a novel nutritional composition for enhancing lean muscle stimulus, growth, strength and recovery, creating and prolonging muscle pumps, supporting endurance, strength, performance, size and stamina, providing a transducer effect for nitric oxide, increasing nutrient delivery and/or promoting increased vascular response, e.g., blood flow and circulation, in an individual, which includes a combination of pharmaceutical grade excipients including Hydroxypropyl Methyl Cellulose (Methocel K100M Premium CR EP-Hypromellose 2208 USP XXII), Ethyl Cellulose (Ethocel Standard FP Premium—NF XVII), and Hydroxypropylcellulose (Klucel LF—NF XVII).
  • The present invention, according to one embodiment thereof, may also provide for a timed release delivery system for a novel nutritional composition for enhancing lean muscle stimulus, growth, strength and recovery, creating and prolonging muscle pumps, supporting endurance, strength, performance, size and stamina, providing a transducer effect for nitric oxide, increasing nutrient delivery and/or promoting increased vascular response, e.g., blood flow and circulation, in an individual, which comprises a hydrophilic caplet matrix system comprising water-soluble (i.e., Hydroxypropyl Methyl Cellulose and Hydroxypropylcellulose) and water-insoluble (i.e., Ethyl Cellulose) polymers uniformly incorporated at a specified ratio.
  • In one timed release delivery system of the present invention, the novel nutritional composition includes a hydrophilic caplet matrix system which is in the ratio of 1 Hydroxypropylcellulose:1 Ethyl Cellulose:0.5 Hydroxypropyl Methyl Cellulose.
  • Although the following examples illustrate the practice of the present invention in some of its embodiments, the examples should not be construed as limiting the scope of the invention. Other embodiments will be apparent to one skilled in the art from consideration of the specification and examples.
    • EXAMPLE 1
  • A serving of the nutritional supplement for enhancing lean muscle stimulus, growth, strength and recovery, creating and prolonging muscle pumps, supporting endurance, strength, performance, size and stamina, providing a transducer effect for nitric oxide, increasing nutrient delivery and/or promoting increased vascular response, e.g., blood flow and circulation, in an individual, includes the following ingredients in caplet form.
    4.852
    Ingredients G/serving Formula %
    L-arginine HCL 3.000 40.000%
    Ginseng (25% ginsenosides) 0.050 0.667%
    Creatine Malate 1.500 20.000%
    L-arginine alpha ketaglutarate 0.100 1.333%
    Citrulline 0.100 1.333%
    L-aspartic acid 0.100 1.333%
    Pycnogenol 0.002 0.027%
    Other Ingredients: 2.648 35.307%
    G/serving
    Potassium Chloride 0.250 3.333%
    Cellulose 0.883 11.773%
    Dextrose 0.057 0.760%
    Stearic Acid 0.560 7.467%
    Silica 0.070 0.933%
    Magnesium Stearate 0.035 0.467%
    Ethyl Cellulose 0.455 6.067%
    Dicalcium Phosphate 0.338 4.507%
    Total 7.500 100.000%
  • Optionally, the caplet form may contain a coating such as Opadry II.
    • EXAMPLE 2
  • A serving of the nutritional composition for enhancing lean muscle stimulus, growth, strength and recovery, creating and prolonging muscle pumps, supporting endurance, strength, performance, size and stamina, providing a transducer effect for nitric oxide, increasing nutrient delivery and/or promoting increased vascular response, e.g., blood flow and circulation, is preferably consumed in accordance with the following directions and dosing chart:
  • DIRECTIONS: Reference is made to the chart below. Based upon a person's bodyweight, one serving (4 to 5 caplets) is taken with an 8 oz. glass of water, 2 times daily. On days of a person's workout, one of these servings is taken, 30 to 60 minutes before the workout. Ten caplets in a 24-hour period should not be exceeded. Ten 8 oz. glasses of water should be ingested daily for general good health. The product may be taken by men.
    CHART
    Up to 200 lbs Over 200 lbs
    8 caplets daily 10 caplets daily
    Take 4 caplets 30 minutes before Take 5 caplets 30 minutes before
    breakfast and again 30 minutes breakfast and aqain 30 minutes before
    before lunch. lunch.
    • EXAMPLE 3
  • An alternate embodiment of the serving of the nutritional supplement for enhancing lean muscle stimulus, growth, strength and recovery, creating and prolonging muscle pumps, supporting endurance, strength, performance, size and stamina, providing a transducer effect for nitric oxide, increasing nutrient delivery and/or promoting increased vascular response, e.g., blood flow and circulation, in an individual, includes the following ingredients in caplet form.
    4.700
    Ingredients g/serving Formula %
    L-arginine HCL 2.900 38.667%
    Creatine Monohydrate 1.500 20.000%
    L-arginine alpha ketaglutarate 0.100 1.333%
    L-Leucine 0.100 1.333%
    L-Valine 0.100 1.333%
    Other Ingredients: 2.800 37.333%
    g/serving
    Potassium Chloride 0.250 3.333%
    Cellulose 1.035 13.800%
    Dextrose 0.057 0.760%
    Stearic Acid 0.560 7.467%
    Silica 0.070 0.933%
    Magnesium Stearate 0.035 0.467%
    Ethyl Cellulose 0.455 6.067%
    Dicalcium Phosphate 0.338 4.507%
    Total 7.500 100.000%
    Coating: Opadry II Grey
  • Optionally, the caplet form may contain a coating such as Opadry II.
    • EXAMPLE 4
  • An alternate embodiment of the serving of the nutritional composition for enhancing lean muscle stimulus, growth, strength and recovery, creating and prolonging muscle pumps, supporting endurance, strength, performance, size and stamina providing a transducer effect for nitric oxide, increasing nutrient delivery and/or promoting increased vascular response, e.g., blood flow and circulation, is preferably consumed in accordance with the following directions and dosing chart:
    DIRECTIONS FOR MEN AND WOMEN: Based upon a person's
    gender and bodyweight, take one serving (2 to 5 caplets) with an 8
    oz. glass of water, 2 times daily. On days of workout, take 1 of these
    servings, 30 to 60 minutes before workout. Do not exceed 10 caplets
    in a 24-hour period. Consume ten 8 fl. oz. glasses of water daily for
    general good health. Read the entire label before use and follow
    directions.
    Minimum Maximum
    daily serving daily serving
    (caplets) Second (caplets) Second
    Gender/lbs First serving Serving First serving Serving
    Women < 125 2 2 3 3
    Women > 125 3 3 4 4
    Men < 200 3 3 4 4
    Men > 200 4 4 5 5
    • EXAMPLE 5
  • A timed release delivery system for a serving of the nutritional supplement for enhancing lean muscle stimulus, growth, strength and recovery, creating and prolonging muscle pumps, supporting endurance, strength, performance, size and stamina, providing a transducer effect for nitric oxide, increasing nutrient delivery and/or promoting increased vascular response, e.g., blood flow and circulation, in an individual including a hydrophilic caplet matrix of Hydroxypropyl Methyl Cellulose (Methocel K100M Premium CR EP-Hypromellose 2208 USP XXII), Ethyl Cellulose (Ethocel Standard FP Premium—NF XVII), and Hydroxypropylcellulose (Klucel LF—NF XVII). The average (n=6) % of labeled amount of arginine dissolved from one caplet of the nutritional supplement for inducing muscle pump and enhancing muscle stimulus and recovery in 900 ml of 0.1N Hydrochloric Acid:
    Average % of Labeled
    Amount of Arginine Average Mg of Arginine
    Time (Minutes) Dissolved ± Std. Dev. Dissolved ± Std. Dev.
    15 10.69 ± 1.69 53.02 ± 8.41
    30 21.18 ± 3.82 105.02 ± 18.92
    45 26.58 ± 9.62 131.63 ± 47.6 
    60 32.74 ± 5.62  161.9 ± 27.76
    120 57.66 ± 6.99 284.61 ± 34.49
    240  91.65 ± 13.76 451.18 ± 67.49
    360 113.30 ± 32.21  555.59 ± 157.52
    480 120.94 ± 38.41 590.13 ± 185.8
    • EXAMPLE 6
  • A serving of the nutritional supplement for enhancing lean muscle stimulus, growth, strength and recovery, creating and prolonging muscle pumps, supporting endurance, strength, performance, size and stamina, providing a transducer effect for nitric oxide, increasing nutrient delivery and/or promoting increased vascular response e.g., blood flow and circulation, in an individual, includes the following ingredients in caplet form.
    Serving:
    4.500
    Ingredient #: g/serving 3 Caplets
    Ingredients
    1 L-arginine HCL 1.740 38.6667%
    2 Creatine Monohydrate 0.900 20.0000%
    3 L-arginine alpha 0.060  1.3333%
    ketoglutarate
    4 L-leucine 0.060  1.3333%
    5 L-valine 0.060  1.3333%
    Other Ingredients:
    6 Potassium Chloride 0.150  3.3333%
    7 Cellulose 0.621 13.8000%
    8 Dextrose 0.034  0.7600%
    9 Stearic Acid 0.336  7.4667%
    10 Silica 0.042  0.9333%
    11 Magnesium Stearate 0.021  0.4667%
    12 Ethyl Cellulose 0.273  6.0667%
    13 Dicalcium Phosphate 0.203  4.5067%
    Coating: Opadry II Red
    4.500 100.000%
    • EXAMPLE 7
  • A serving of the nutritional supplement (PUMP-TECH GRAPE FLAVOR) for enhancing lean muscle stimulus, growth, strength and recovery, creating and prolonging muscle pumps, supporting endurance, strength, performance, size and stamina, providing a transducer effect for nitric oxide, increasing nutrient delivery and/or promoting increased vascular response, e.g., blood flow and circulation, in an individual, includes the following ingredients in powder form reconstituted into a drink.
    Dietary
    Ingredient
    per serving Actives/
    Dietary Ingredient Name Actives % (g) serving (g) Formula %
    L-arginine 4.0000 68.3527%
    Di-Creatine Malate 1.5000 25.6323%
    Creatine 63 0.9450
    L-arginine alpha ketaglutarate (2:1) 0.1000  1.7088%
    Arginine 69 0.0690
    Picamilone HCL 0.1000  1.7088%
    Asian Ginseng Powder root extract 0.0500  0.8544%
    (Panax ginseng)
    Ginsenosides (standardized) 25 0.0125
    L-Citrulline 0.0500  0.8544%
    L-aspartic acid 0.0500  0.8544%
    French Maritime Pine Bark Extract 0.0020  0.0342%
    Proanthocyanidins Standardized (Pinus 70 0.0014
    Maritima)
    5.8520  100.00%
    Other Ingredients g/serving %
    Dextrose 6.0000  62.9%
    Citric Acid 2.4600  25.8%
    SD N&A Bitter Blocker 0.6250   6.5%
    SD N&A Concord Grape Flavor 0.1870   2.0%
    Natural Sweetness Modifier Flavor 0.1750   1.8%
    Sucralose 0.0550   0.6%
    Acesulfame K 0.0270   0.3%
    FD&C Blue #1 (10%) 0.0080   0.1%
    FD&C Red #40 0.0060   0.1%
    9.5430 100.00%
    • EXAMPLE 8
  • One serving of the supplement of Example 7 is consumed by a human, twice daily.
    • EXAMPLE 9
  • A serving of the nutritional composition (PUMPTECH FRUIT PUNCH FLAVOR) for enhancing lean muscle stimulus, growth, strength and recovery, creating and prolonging muscle pumps, supporting endurance, strength, performance, size and stamina, providing a transducer effect for nitric oxide, increasing nutrient delivery and/or promoting increased vascular response, e.g., blood flow and circulation, is preferably consumed in powder form reconstituted into a drink.
    Dietary
    Ingredient
    Dietary Ingredient per serving Actives/
    Name Actives % (g) serving (g) Formula %
    L-arginine 4.0000 68.3527% 
    Di-Creatine Malate 1.5000 25.6323% 
    Creatine 63 0.9450
    L-arginine alpha 0.1000 1.7088%
    ketaglutarate (2:1)
    Arginine 69 0.0690
    Picamilone HCL 0.1000 1.7088%
    Asian Ginseng 0.0500 0.8544%
    Powder root
    extract (Panax
    ginseng)
    Ginsenosides 25 0.0125
    Standardized
    L-Citrulline 0.0500 0.8544%
    L-aspartic acid 0.0500 0.8544%
    French Maritime 0.0020 0.0342%
    Pine Bark Extract
    Proanthocyanidins 70 0.0014
    Standardized (Pinus
    Maritima)
    5.8520 100.00%
    Other Ingredients g/serving %
    Dextrose 6.0000 59.9% 
    Citric Acid 2.4600 24.5% 
    SD N&A Bitter Blocker 0.6250 6.2%
    SD Natural Pineapple Flavor WONF 0.3700 3.7%
    SD N&A Fruit Punch Flavor 0.3000 3.0%
    Natural Sweetness Modifier Flavor 0.1750 1.7%
    Sucralose 0.0550 0.5%
    Acesulfame K 0.0270 0.3%
    FD&C Red #40 0.0090 0.1%
    10.0210 100.00%  
    • EXAMPLE 10
  • One serving of the supplement of Example 9 is consumed by a human, twice daily.
    • EXAMPLE 11
  • A serving of the nutritional composition (PUMPTECH CAPLET) for enhancing lean muscle stimulus, growth, strength and recovery, creating and prolonging muscle pumps, supporting endurance, strength, performance, size and stamina, providing a transducer effect for nitric oxide, increasing nutrient delivery and/or promoting increased vascular response, e.g., blood flow and circulation, is preferably consumed in caplet form.
    Dietary
    Ingredient
    Dietary Ingredient per serving Actives/
    Name Actives % (g) serving (g) Formula %
    L-arginine 4.0000 68.3527% 
    Di-Creatine Malate 1.5000 25.6323% 
    Creatine 63 0.9450
    L-arginine alpha 0.1000 1.7088%
    ketaglutarate (2:1)
    Arginine 66 0.0660
    Picamilon HCL 0.1000 1.7088%
    Asian Ginseng 0.0500 0.8544%
    Extract (Panax
    Ginseng)
    Std to Ginsenosides 25 0.0125
    L-Citrulline 0.0500 0.8544%
    L-aspartic acid 0.0500 0.8544%
    French Maritime 0.0020 0.0342%
    Pine Bark Extract
    (Pinus maritima)
    Std to 70 0.0014
    Proanthocyanidins
    5.8520 100.00%
    Other Ingredients g/serving %
    Potassium Chloride 0.0000
    Cellulose 0.0000
    Dextrose 0.0000
    Stearic Acid 0.0000
    Silica 0.0000
    Magnesium Stearate 0.0000
    Ethyl Cellulose 0.0000
    Dicalcium Phosphate 0.0000
    Coating: Opadry II Red 0.0000
    Polyvinyl Alcohol 0.0000
    Polyethylene Glycol 0.0000
    FD & C Red #40 AC Aluminum Lake 0.0000
    Talc 0.0000
    Titanium Dioxide 0.0000
    0.0000 0.0000%
    • EXAMPLE 12
  • One serving of the supplement of Example 11 is consumed by a human, twice daily, each serving including 5 caplets.

Claims (21)

1. A nutritional composition for at least one of enhancing lean muscle stimulus, growth, strength and recovery, creating and prolonging muscle pumps, supporting endurance, strength, performance, size and stamina, providing a transducer effect for nitric oxide, increasing nutrient delivery and/or promoting increased vascular response, in individuals, the nutritional composition comprising L-arginine and creatine.
2. The nutritional composition of claim 1, further comprising L-citrulline, L-aspartic acid, ginseng root extract, and maritime pine (bark) extract.
3. The nutritional composition of claim 1, wherein the L-arginine includes L-arginine HCL and L-arginine alphaketoglutarate.
4. The nutritional composition of claim 2, wherein the L-arginine includes L-arginine base and L-arginine alphaketoglutarate.
5. The nutritional composition of claim 1, wherein the creatine includes di-creatine malate.
6. The nutritional composition of claim 1, further comprising L-leucine and L-valine.
7. The nutritional composition of claim 1, wherein the nutritional composition is provided in the form of one of a caplet and a powder suitable for reconstitution in a liquid.
8. A method for at least one of enhancing lean muscle stimulus, growth, strength and recovery, creating and prolonging muscle pumps, supporting endurance, strength, performance, size and stamina, providing a transducer effect for nitric oxide, increasing nutrient delivery and/or promoting increased vascular response in individuals, the method comprising the step of:
consuming a nutritional composition comprising L-arginine and creatine.
9. The method of claim 8, wherein the nutritional composition further comprises L-citrulline, L-aspartic acid, ginseng root extract, and maritime pine (bark) extract.
10. The method of claim 9, wherein the L-arginine includes L-arginine HCL and L-arginine alphaketoglutarate.
11. The method of claim 8, wherein the L-arginine includes L-arginine base and L-arginine alphaketoglutarate.
12. The method of claim 8, wherein the creatine includes di-creatine malate.
13. The method of claim 8, wherein the nutritional composition further comprises L-leucine and L-valine.
14. The method of claim 8, wherein the nutritional composition is consumed in the form of one of a caplet and a powder suitable for reconstitution in a liquid.
15. A method of manufacturing a nutritional composition for at least one of enhancing lean muscle stimulus, growth, strength and recovery, creating and prolonging muscle pumps, supporting endurance, strength, performance, size and stamina, providing a transducer effect for nitric oxide, increasing nutrient delivery and/or promoting increased vascular response in individuals, the method comprising the steps of:
creating a mixture of L-arginine and creatine;
blending the mixture; and
aliquoting the mixture into a serving.
16. The method of claim 15, wherein the mixture is aliquoted into a serving, the serving in the form of one of a caplet and a powder beverage mix.
17. The method of claim 15, further comprising the step of adding in the mixture at least one of L-citrulline, L-aspartic acid, ginseng root extract, and maritime pine (bark) extract.
18. The method of claim 15, further comprising the step of adding in the mixture at least one of L-leucine and L-valine.
19. The method of claim 15, wherein the step of adding in the mixture the L-arginine includes adding L-arginine HCL and L-arginine alphaketoglutarate.
20. The method of claim 15, wherein the step of adding in the mixture the L-arginine includes adding L-arginine base and L-arginine alphaketoglutarate.
21. The method of claim 15, wherein the step of adding in the mixture the creatine includes adding di-creatine malate.
US11/119,168 2004-04-30 2005-04-29 Nutritional composition for enhancing lean muscle stimulus, growth, strength and recovery, creating and prolonging intense muscle pumps, supporting endurance, strength, performance, size and stamina, providing a transducer effect for nitric oxide, increasing nutrient delivery and/or promoting increased vascular response in an individual Abandoned US20050256192A1 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US11/119,168 US20050256192A1 (en) 2004-04-30 2005-04-29 Nutritional composition for enhancing lean muscle stimulus, growth, strength and recovery, creating and prolonging intense muscle pumps, supporting endurance, strength, performance, size and stamina, providing a transducer effect for nitric oxide, increasing nutrient delivery and/or promoting increased vascular response in an individual
US11/876,390 US20080089962A1 (en) 2004-09-24 2007-10-22 Nutritional composition for facilitating muscle pumps
US12/291,478 US7939113B2 (en) 2004-04-30 2008-11-10 Nutritional composition for facilitating muscle pumps

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US56712704P 2004-04-30 2004-04-30
US61344104P 2004-09-24 2004-09-24
US65878205P 2005-03-03 2005-03-03
US11/119,168 US20050256192A1 (en) 2004-04-30 2005-04-29 Nutritional composition for enhancing lean muscle stimulus, growth, strength and recovery, creating and prolonging intense muscle pumps, supporting endurance, strength, performance, size and stamina, providing a transducer effect for nitric oxide, increasing nutrient delivery and/or promoting increased vascular response in an individual

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US11/876,390 Continuation-In-Part US20080089962A1 (en) 2004-04-30 2007-10-22 Nutritional composition for facilitating muscle pumps

Publications (1)

Publication Number Publication Date
US20050256192A1 true US20050256192A1 (en) 2005-11-17

Family

ID=35320722

Family Applications (2)

Application Number Title Priority Date Filing Date
US11/119,168 Abandoned US20050256192A1 (en) 2004-04-30 2005-04-29 Nutritional composition for enhancing lean muscle stimulus, growth, strength and recovery, creating and prolonging intense muscle pumps, supporting endurance, strength, performance, size and stamina, providing a transducer effect for nitric oxide, increasing nutrient delivery and/or promoting increased vascular response in an individual
US12/291,478 Expired - Fee Related US7939113B2 (en) 2004-04-30 2008-11-10 Nutritional composition for facilitating muscle pumps

Family Applications After (1)

Application Number Title Priority Date Filing Date
US12/291,478 Expired - Fee Related US7939113B2 (en) 2004-04-30 2008-11-10 Nutritional composition for facilitating muscle pumps

Country Status (3)

Country Link
US (2) US20050256192A1 (en)
CA (1) CA2564886A1 (en)
WO (1) WO2005107735A2 (en)

Cited By (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070014878A1 (en) * 2005-03-18 2007-01-18 Gardiner Paul T Compositions and methods for increasing metabolism, thermogenesis and/or muscular definition
WO2007002294A3 (en) * 2005-06-22 2007-03-29 Advocare International L P Composition for enhancing cellular energy
US20070141122A1 (en) * 2005-12-21 2007-06-21 Angel Sports Nutrition, Inc. Nutritional composition and method of manufacture
WO2008105325A1 (en) * 2007-02-23 2008-09-04 Kyowa Hakko Bio Co., Ltd. Citrulline-containing beverage
US20090105196A1 (en) * 2007-06-22 2009-04-23 Belinda Tsao Nivaggioli Use of creatine compounds to treat dermatitis
EP2007407A4 (en) * 2006-03-20 2009-08-19 Ripped Formulations Ltd Compositions and methods for increasing metabolism, thermogenesis and/or muscular definition
US20110044965A1 (en) * 2008-04-02 2011-02-24 Androsystems S.R.L. L-citrulline for treating endothelial dysfunction and erectile dysfunction
US20110123654A1 (en) * 2008-06-06 2011-05-26 Ralf Jaeger Synergistic enhancement of cellular ergogenic nutrient uptake, like creatine or carnitine, with tarragon
US20110217393A1 (en) * 2010-02-23 2011-09-08 Grise Michel Anti-fatigue composition
US20120045426A1 (en) * 2010-08-21 2012-02-23 St Cyr John A Compositions for reducing the deleterious effects of stress and aging
WO2016123659A1 (en) * 2015-02-05 2016-08-11 Plasmaide Pty Ltd A composition and formulation of pine bark extract (pbe) for providing health benefits
US11534419B2 (en) 2011-04-13 2022-12-27 Thermolife International, Llc N-acetyl beta alanine methods of use
US11723917B2 (en) 2007-02-26 2023-08-15 Heartbeet Ltd. Compositions of nitrates and methods of use thereof
US11759477B2 (en) 2007-02-26 2023-09-19 Heartbeet Ltd. Compositions of nitrates and methods of use thereof
US11865139B2 (en) 2020-11-12 2024-01-09 Thermolife International, Llc Method of treating migraines and headaches
US12156886B2 (en) 2020-11-12 2024-12-03 Thermolife International, Llc Methods of increasing blood oxygen saturation
US12227483B1 (en) 2007-09-18 2025-02-18 Thermolife International, Llc Amino acid compositions
US12441615B2 (en) 2021-02-11 2025-10-14 Thermolife International, Llc Method of administering nitric oxide gas

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2007009450A (en) * 2005-02-07 2007-10-23 New Cell Formulations Ltd Creatine hydroxycitric acids salts and methods for their production and use in individuals.
EP2679223A1 (en) * 2006-04-04 2014-01-01 Nestec S.A. Treatments using citrulline
ES2861583T3 (en) * 2007-10-10 2021-10-06 Kyowa Hakko Bio Co Ltd Rapid-acting oral preparation that can increase the level of arginine in the blood and comprises citrulline and arginine
CN102028230B (en) * 2010-12-08 2014-12-10 江南大学 Health care product auxiliary material and application thereof
MX2013012228A (en) * 2011-04-18 2013-12-06 Nestec Sa Nutritional compositions comprising alpha-hydroxyisocaproic acid.
CN103263018A (en) * 2013-04-27 2013-08-28 北京中国科学院老专家技术中心 Nitric oxide functional beverage and preparation method thereof
US11102994B2 (en) * 2014-08-21 2021-08-31 Clearfast Inc. Pre-operative carbohydrate-rich beverage composition and methods of treatment
US10674746B2 (en) 2015-10-27 2020-06-09 Cytozyme Animal Nutrition, Inc. Animal nutrition compositions and related methods
WO2017075289A1 (en) 2015-10-27 2017-05-04 Cytozyme Animal Nutrition, Inc. Animal nutrition compositions and related methods

Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4698360A (en) * 1985-04-09 1987-10-06 Societe Civile D'investigations Pharmacologiques D'aquitaine Plant extract with a proanthocyanidins content as therapeutic agent having radical scavenger effect and use thereof
US5783603A (en) * 1995-05-15 1998-07-21 Sabinsa Corporation Potassium hydroxycitrate for the suppression of appetite and induction of weight loss
US6160172A (en) * 1997-08-27 2000-12-12 Vittal Mallya Scientific Research Foundation Soluble double metal salt of group IA and IIA of (-) hydroxycitric acid, process of preparing the same and its use in beverages and other food products without effecting their flavor and properties
US6203820B1 (en) * 1998-05-28 2001-03-20 Brice E. Vickery Compositions and methods for enhancing protein anabolism and detoxification
US6383482B1 (en) * 2000-08-24 2002-05-07 Vitacost.Com, Inc. Weight loss composition containing green tea, hydroxycitric acid, 5-hydroxytryptophan, glucomannan, picolinate and lactobacillus
US6384087B1 (en) * 2000-09-01 2002-05-07 University Of Tennesseee Research Corporation, Inc. Materials and methods for the treatment or prevention of obesity
US6638542B2 (en) * 2001-09-20 2003-10-28 Nutricia N.V. Reducing appetite in mammals by administering procyanidin and hydroxycitric acid
US20030207942A1 (en) * 2002-04-30 2003-11-06 Unibar Corporation Hydroxycitric acid salt composition and method of making
US20040071825A1 (en) * 2002-10-15 2004-04-15 Christopher Lockwood Agglomerated granular protein-rich nutritional supplement
US20040229953A1 (en) * 2003-05-12 2004-11-18 Gokaraju Ganga Raju Process for preparing highly water soluble double salts of hydroxycitric acid particularly alkali and alkaline earth metal double salts

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3736776B2 (en) 1997-03-25 2006-01-18 宝ホールディングス株式会社 New calcium composition
JP2001527022A (en) 1997-07-14 2001-12-25 ラジュ、ジー・ガンガ Hydroxycitric acid compositions, supplements and supplements and foods made therefrom and methods of using them in reducing body weight
US20020068365A1 (en) * 1998-07-28 2002-06-06 Eric H. Kuhrts Controlled release nitric oxide producing agents
US6541026B2 (en) 1999-12-16 2003-04-01 Harry J. Siskind Nutritional composition, methods of producing said composition and methods of using said composition
AU2001282373A1 (en) * 2000-05-26 2001-12-03 Horphag Research Limited Use of proanthocyanidins as an active ingredient of a stimulator and l-arginine or its salts as a source of nitric oxide to relieve symptoms of erectile dysfuntion
US20030119913A1 (en) 2001-12-20 2003-06-26 Ohia Sunny E. Method for increasing serotonin levels in a person by administration of a composition incorporating (-)-hydroxycitric acid, and related compositions thereof
WO2003088947A1 (en) * 2002-04-22 2003-10-30 Experimental & Applied Sciences, Inc. Food supplements containing 4-hydroxyisoleucine and creatine

Patent Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4698360A (en) * 1985-04-09 1987-10-06 Societe Civile D'investigations Pharmacologiques D'aquitaine Plant extract with a proanthocyanidins content as therapeutic agent having radical scavenger effect and use thereof
US4698360B1 (en) * 1985-04-09 1997-11-04 D Investigations Pharmacologiq Plant extract with a proanthocyanidins content as therapeutic agent having radical scavenger effect and use thereof
US5783603A (en) * 1995-05-15 1998-07-21 Sabinsa Corporation Potassium hydroxycitrate for the suppression of appetite and induction of weight loss
US6160172A (en) * 1997-08-27 2000-12-12 Vittal Mallya Scientific Research Foundation Soluble double metal salt of group IA and IIA of (-) hydroxycitric acid, process of preparing the same and its use in beverages and other food products without effecting their flavor and properties
US6203820B1 (en) * 1998-05-28 2001-03-20 Brice E. Vickery Compositions and methods for enhancing protein anabolism and detoxification
US6383482B1 (en) * 2000-08-24 2002-05-07 Vitacost.Com, Inc. Weight loss composition containing green tea, hydroxycitric acid, 5-hydroxytryptophan, glucomannan, picolinate and lactobacillus
US6384087B1 (en) * 2000-09-01 2002-05-07 University Of Tennesseee Research Corporation, Inc. Materials and methods for the treatment or prevention of obesity
US6638542B2 (en) * 2001-09-20 2003-10-28 Nutricia N.V. Reducing appetite in mammals by administering procyanidin and hydroxycitric acid
US20030207942A1 (en) * 2002-04-30 2003-11-06 Unibar Corporation Hydroxycitric acid salt composition and method of making
US20040071825A1 (en) * 2002-10-15 2004-04-15 Christopher Lockwood Agglomerated granular protein-rich nutritional supplement
US20040229953A1 (en) * 2003-05-12 2004-11-18 Gokaraju Ganga Raju Process for preparing highly water soluble double salts of hydroxycitric acid particularly alkali and alkaline earth metal double salts

Cited By (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070014878A1 (en) * 2005-03-18 2007-01-18 Gardiner Paul T Compositions and methods for increasing metabolism, thermogenesis and/or muscular definition
US7943183B2 (en) 2005-03-18 2011-05-17 Gardiner Paul T Compositions and methods for increasing metabolism, thermogenesis and/or muscular definition
WO2007002294A3 (en) * 2005-06-22 2007-03-29 Advocare International L P Composition for enhancing cellular energy
US20070141122A1 (en) * 2005-12-21 2007-06-21 Angel Sports Nutrition, Inc. Nutritional composition and method of manufacture
EP2007407A4 (en) * 2006-03-20 2009-08-19 Ripped Formulations Ltd Compositions and methods for increasing metabolism, thermogenesis and/or muscular definition
WO2008105325A1 (en) * 2007-02-23 2008-09-04 Kyowa Hakko Bio Co., Ltd. Citrulline-containing beverage
US11759477B2 (en) 2007-02-26 2023-09-19 Heartbeet Ltd. Compositions of nitrates and methods of use thereof
US11723917B2 (en) 2007-02-26 2023-08-15 Heartbeet Ltd. Compositions of nitrates and methods of use thereof
US20090105196A1 (en) * 2007-06-22 2009-04-23 Belinda Tsao Nivaggioli Use of creatine compounds to treat dermatitis
US12473261B2 (en) 2007-09-18 2025-11-18 Thermolife International, Llc Amino acid compositions
US12448357B1 (en) 2007-09-18 2025-10-21 Thermolife International, Llc Amino acid compositions
US12240819B1 (en) 2007-09-18 2025-03-04 Thermolife International, Llc Amino acid compositions
US12227483B1 (en) 2007-09-18 2025-02-18 Thermolife International, Llc Amino acid compositions
US8802162B2 (en) 2008-04-02 2014-08-12 Androsystems S.R.L. L-citrulline for treating endothelial dysfunction and erectile dysfunction
US20110044965A1 (en) * 2008-04-02 2011-02-24 Androsystems S.R.L. L-citrulline for treating endothelial dysfunction and erectile dysfunction
US20110123654A1 (en) * 2008-06-06 2011-05-26 Ralf Jaeger Synergistic enhancement of cellular ergogenic nutrient uptake, like creatine or carnitine, with tarragon
US20110217393A1 (en) * 2010-02-23 2011-09-08 Grise Michel Anti-fatigue composition
US9408894B2 (en) 2010-02-23 2016-08-09 Michel Grise Anti-fatigue composition
US20160199460A1 (en) * 2010-08-21 2016-07-14 Hydropep, Llc Compositions for reducing the deleterious effects of stress and aging
US20120045426A1 (en) * 2010-08-21 2012-02-23 St Cyr John A Compositions for reducing the deleterious effects of stress and aging
US11534419B2 (en) 2011-04-13 2022-12-27 Thermolife International, Llc N-acetyl beta alanine methods of use
WO2016123659A1 (en) * 2015-02-05 2016-08-11 Plasmaide Pty Ltd A composition and formulation of pine bark extract (pbe) for providing health benefits
US12156886B2 (en) 2020-11-12 2024-12-03 Thermolife International, Llc Methods of increasing blood oxygen saturation
US11865139B2 (en) 2020-11-12 2024-01-09 Thermolife International, Llc Method of treating migraines and headaches
US12441615B2 (en) 2021-02-11 2025-10-14 Thermolife International, Llc Method of administering nitric oxide gas

Also Published As

Publication number Publication date
WO2005107735A2 (en) 2005-11-17
US20090155379A1 (en) 2009-06-18
CA2564886A1 (en) 2005-11-17
WO2005107735A3 (en) 2006-07-13
US7939113B2 (en) 2011-05-10

Similar Documents

Publication Publication Date Title
US7939113B2 (en) Nutritional composition for facilitating muscle pumps
EP2210600B1 (en) Rapid-acting, blood-arginine-level-increasable oral preparation comprising citrulline and arginine
US20060083793A1 (en) Nutritional composition for promoting muscle performance and acting as hydrogen (H+) blocker
US20110064712A1 (en) Dietary Supplement Compositions and Methods of Making and Using the Same
JP2873497B2 (en) Lipid metabolism regulator
US20200237792A1 (en) Palatinose for enhancing dietary supplement and pharmaceutical delivery
US20090297640A1 (en) Nutritional composition for increasing creatine uptake in skeletal muscle
JP2011509293A (en) Compositions and methods for increasing muscle mass, strength and functional ability of the elderly
US20090306209A1 (en) Enteric-coated formulations of polyethylene glycol and one or more soluble amino acids for oral ingestion and enhanced uptake of same
US20230089723A1 (en) Amino acid compositions and methods for muscle and myotube modulation
US5626831A (en) Method for relief and prevention of common cold, and compositions
US20080089962A1 (en) Nutritional composition for facilitating muscle pumps
US20150224136A1 (en) Performance-Enhancing Nasal Irrigation
WO1995022967A1 (en) Analgesic activity enhancer
Kobrin et al. Antihypertensive duration of action of cilazapril in patients with mild to moderate essential hypertension
EP3809882A1 (en) Nutritional compositions for enhancement of muscle performance
JP2006510640A (en) Formulations that can be administered to the gastrointestinal tract and uses thereof
TWI377937B (en) Non-essential amino acids containing pharmaceutical composition and uses thereof
JP2019142781A (en) Drunkenness countermeasure composition
JP2018121535A (en) Beverage

Legal Events

Date Code Title Description
AS Assignment

Owner name: PUMP FORMULATIONS LTD., CANADA

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:GARDINER, PAUL T.;HEUER, MARVIN A.;REEL/FRAME:016550/0077;SIGNING DATES FROM 20050719 TO 20050720

STCB Information on status: application discontinuation

Free format text: ABANDONED -- FAILURE TO RESPOND TO AN OFFICE ACTION