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US20040092829A1 - Spectroscope with modified field-of-view - Google Patents

Spectroscope with modified field-of-view Download PDF

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Publication number
US20040092829A1
US20040092829A1 US10/289,741 US28974102A US2004092829A1 US 20040092829 A1 US20040092829 A1 US 20040092829A1 US 28974102 A US28974102 A US 28974102A US 2004092829 A1 US2004092829 A1 US 2004092829A1
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United States
Prior art keywords
spectroscope
fiber
view
field
obstruction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US10/289,741
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English (en)
Inventor
Simon Furnish
Andres Zuluaga
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Infraredx Inc
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Infraredx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US10/289,741 priority Critical patent/US20040092829A1/en
Application filed by Infraredx Inc filed Critical Infraredx Inc
Assigned to PRIEST, WILLIAM W., MARQUARD, WILLIAM A. reassignment PRIEST, WILLIAM W. SECURITY AGREEMENT Assignors: INFRAREDX, INC.
Assigned to DEWEY JR., ROBERT M., FLAHERTY, PETER A., DENNING, RICHARD B., MARTINELLI, ALFRED, SILVERSTEIN, MARK AND HEIDI, DB SECURITIES INC CUST FBO ALAN J. ZAKON, BUTLER, JAMES C., PAUL F. MULLER LIVING TRUST DATED SEPTEMBER 25, 1997, WILHELM, LYNN, 562 MISSION STREET, LLC, OSTERWEIS REVOCABLE TRUST, THE, U/A DATED 9/13/93, GLOUTNEY, PIERRE, HOLLAND, WILLIAM, WOOD, W. DAVID, PAULI, DAVID C., MCGARTY, JOHN J., DATER, ELIZABETH, SUBRAMANIAM, SOMU, ROSSTON FAMILY REVOCABLE TRUST, THE, U/A DATED 9/22/94, KETTLE FAMILY LIMITED PARTNERSHIP reassignment DEWEY JR., ROBERT M. SECURITY AGREEMENT Assignors: INFRAREDX, INC.
Assigned to INFRAREDX, INC. reassignment INFRAREDX, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: FURNISH, SIMON M., ZULUAGA, ANDRES
Assigned to INFRAREDX, INC. reassignment INFRAREDX, INC. RELEASE BY SECURED PARTY (SEE DOCUMENT FOR DETAILS). Assignors: 562 MISSION STREET, LLC, BUTLER, JAMES C., DATER, ELIZABETH, DENNING, RICHARD B., DEWEY, JR., ROBERT M., FLAHERTY, PETER A., GLOUTNEY, PIERRE, HOLLAND, WILLIAM, KETTLE FAMILY LIMITED PARTNERSHIP, MARK & HEIDI SILVERSTEIN, MARQUARD, WILLIAM A., MARTINELLI, ALFRED, MCGARTY, JOHN J., PAUL F. MULLER LIVING TRUST DATED SEPTEMBER 25, 1997, PAULI, DAVID C., PRIEST, WILLIAM W., SUBRAMANIAM, SOMU, THE OSTERWEIS REVOCABLE TRUST U/A DATED 09/13/93 JOHN S. OSTERWEIS AS TRUSTEE, THE ROSSTON FAMILY REVOCABLE TRUST U/A DATED 09/22/94, JOHN W. ROSSTON & BARBARA H. ROSSTON AS TRUSTEES, WILHELM, LYNN, WOOD, W. DAVID, DB SECURITIES INC CUST FBO ALAN J. ZAKON R-IRA ACCOUNT # 235-85974-13
Priority to AU2003291401A priority patent/AU2003291401A1/en
Priority to PCT/US2003/035692 priority patent/WO2004043251A1/fr
Priority to JP2004551957A priority patent/JP2006505360A/ja
Priority to EP03768797A priority patent/EP1558127A4/fr
Publication of US20040092829A1 publication Critical patent/US20040092829A1/en
Priority to US11/772,887 priority patent/US7873406B2/en
Priority to US12/641,811 priority patent/US20100160792A1/en
Priority to JP2010000840A priority patent/JP2010142649A/ja
Abandoned legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0062—Arrangements for scanning
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0075—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
    • A61B5/0084—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
    • A61B5/02007—Evaluating blood vessel condition, e.g. elasticity, compliance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/02—Details of sensors specially adapted for in-vivo measurements
    • A61B2562/0233—Special features of optical sensors or probes classified in A61B5/00
    • A61B2562/0242—Special features of optical sensors or probes classified in A61B5/00 for varying or adjusting the optical path length in the tissue

Definitions

  • the invention relates to spectroscopy, and in particular, to spectroscopes for detecting vulnerable plaques within a wall of a blood vessel.
  • Atherosclerosis is a vascular disease characterized by a modification of the walls of blood-carrying vessels. Such modifications, when they occur at discrete locations or pockets of diseased vessels, are referred to as plaques. Certain types of plaques are associated with acute events such as stroke or myocardial infarction. These plaques are referred to as “vulnerable plaques.”
  • a vulnerable plaque typically includes a lipid-containing pool of necrotic debris separated from the blood by a thin fibrous cap. In response to elevated intraluminal pressure or vasospasm, the fibrous cap can become disrupted, exposing the contents of the plaque to the flowing blood. The resulting thrombus can lead to ischemia or to the shedding of emboli.
  • One method of locating vulnerable plaque is to peer through the arterial wall with infrared light. To do so, one inserts a catheter through the lumen of the artery.
  • the catheter includes a delivery fiber for illuminating a spot on the arterial wall with infrared light.
  • Various particles in the blood, as well as the arterial wall itself scatter or reflect much of this light.
  • a small portion of the light penetrates the arterial wall, scatters off structures deep within the wall. Some of this deeply-scattered light re-enters the lumen. This re-entrant light be collected by a collection fiber within the catheter and subjected to spectroscopic analysis.
  • the collection fiber preferably rejects such light and directs only re-entrant light into the collection fiber.
  • the invention is based on the recognition that one can use the differing spatial distributions of specularly reflected light and re-entrant light to preferentially guide re-entrant light into the collection fiber.
  • the invention includes a spectroscope having an optical fiber extending through a catheter.
  • An obstruction is placed so as to occlude a portion of a field-of-view of the optical fiber.
  • the obstruction includes a ledge extending across a chord of fiber core so as to occlude a region bounded by the chord and by a boundary of the core.
  • the obstruction includes a tab extending at least part way across the core.
  • the obstruction includes a disk disposed to occlude a circular portion of the core.
  • the obstruction need not be adjacent to the fiber.
  • the obstruction in spectroscopes that include a mirror in optical communication with the optical fiber, can be a non-reflective region of the mirror shaped to obstruct a portion of the fibers field-of-view.
  • the obstruction can be walls forming an aperture in optical communication with the fiber, the aperture being shaped to obstruct a portion of the fibers field-of-view.
  • the obstruction can be an opaque band in optical communication with the fiber and positioned to obstruct a portion of the fibers field-of-view.
  • the resulting field of view of the optical fiber depends in part on the shape of the obstruction.
  • the obstruction has a shape selected to form a field-of-view in the shape of a truncated ellipse. This includes the special case of a truncated circle, a circle being an ellipse with coincident foci.
  • the obstruction has a shape selected to form a crescent-shaped field-of-view.
  • the obstruction has a shape selected to form an annular field-of-view. Additional embodiments include those in which the obstruction has a diffracting edge, the geometry of which is selected to form a selected field-of-view.
  • Another aspect of the invention includes a spectroscope having an optical fiber that extends through a catheter.
  • An optical system having a finite focal length is disposed to be in optical communication with the fiber.
  • the optical system includes an optical element having a curved surface.
  • optical elements include mirrors and lenses.
  • the curved surface can be a cylindrical surface, or it can be a paraboloid, an ellipsoid, a hyperboloid, or a sphere.
  • the optical system includes an optical element with a spatially varying index of refraction.
  • Another aspect of the invention includes a spectroscope having a catheter and an optical fiber extending through the catheter.
  • a diffracting element configured to form a selected field-of-view is in optical communication with the fiber.
  • Embodiments of the spectroscope include those in which the diffracting element is a transmissive diffracting element and those in which the diffracting element is reflective diffracting element. Other embodiments include those in which the diffracting element is a diffraction grating, an amplitude grating, a phase grating, or a holographic grating.
  • FIG. 1 is a schematic of a system for identifying vulnerable plaque in a patient.
  • FIG. 2 is a cross-section of the catheter in FIG. 1.
  • FIG. 3 is a view of an optical bench at the tip assembly of the catheter in FIG. 1.
  • FIG. 4 is a schematic of the paths traveled by light from the illumination fiber of FIG. 1.
  • FIG. 5 is a cross-section of the spatial light distribution shown in FIG. 4.
  • FIG. 6 is a transverse cut of the collection fiber and optical bench showing a known collection-fiber stop.
  • FIG. 7 is a schematic of the field-of-view of the collection fiber of FIG. 6 superimposed on the spatial light distribution of FIG. 4.
  • FIGS. 8 and 9 are longitudinal and transverse cross-sections of an optical bench having an extended collection-fiber stop.
  • FIG. 10 is a schematic of a field-of-view of resulting from the extended collection-fiber stop of FIGS. 8 and 9.
  • FIGS. 11 and 12 are longitudinal and transverse cross-sections of an optical bench having a tab protruding from the collection-fiber stop.
  • FIG. 13 is a schematic of a crescent-shaped field of view resulting from the tab of FIGS. 11 and 12.
  • FIGS. 14 and 15 are longitudinal and transverse cross-sections of an optical bench having an occluding disk supported on a post protruding from the collection-fiber stop.
  • FIG. 16 is a plan view of a mask on the collection mirror.
  • FIG. 17 is a schematic of a perforated shell enclosing the distal tip assembly.
  • FIG. 18 is a schematic of a banded sheath enclosing the distal tip assembly.
  • FIG. 19 is a schematic of a mirror having a curved surface in optical communication with the collection fiber.
  • FIGS. 20 and 21 are schematics of exemplary fields-of-view as modified by mirrors having various curved surfaces.
  • FIG. 22 is a schematic of a lens in optical communication with the collection fiber.
  • FIG. 23 is a schematic of a transmissive diffracting element in optical communication with the collection fiber.
  • FIG. 24 is a schematic of a reflective diffractive element integrated onto the surface of the collection mirror.
  • FIG. 1 shows a diagnostic system 10 for identifying vulnerable plaque 12 in an arterial wall 14 of a patient.
  • the diagnostic system features a catheter 16 to be inserted into a selected artery, e.g. a coronary artery, of the patient.
  • a delivery fiber 18 and a collection fiber 20 extend between a distal end 22 and a proximal end 24 of the catheter 16 .
  • the catheter 16 includes a sheath 26 surrounding a rotatable torque cable 28 .
  • the delivery fiber 18 extends along the center of a torque cable 28
  • the collection fiber 20 extends parallel to, but radially displaced from, the delivery fiber 18 .
  • the rotatable torque cable 28 spins at a rate between approximately 1 revolution per second and 400 revolutions per second.
  • a tip assembly 30 coupled to the torque cable 28 directs light traveling axially on the delivery fiber 18 toward an illumination spot 32 on the arterial wall 14 .
  • the tip assembly 30 also collects light from a field-of-view 34 on the arterial wall 14 and directs that light into the collection fiber 20 .
  • a multi-channel coupler 36 driven by a motor 38 engages the proximal end 24 of the torque cable 28 .
  • the motor 38 spins the multi-channel coupler 36
  • both the coupler 36 , the torque cable 28 , and the tip assembly 30 spin together as a unit. This feature enables the diagnostic system 10 to circumferentially scan the arterial wall 14 with the illumination spot 32 .
  • the multi-channel coupler 36 guides light from a laser 40 (or other light source such as a light-emitting diode, a super-luminescent diode, or an arc lamp) into the delivery fiber 18 and guides light emerging from the collection fiber 20 into one or more detectors (not visible in FIG. 1).
  • a laser 40 or other light source such as a light-emitting diode, a super-luminescent diode, or an arc lamp
  • the detectors provide an electrical signal indicative of light intensity to an amplifier 42 connected to an analog-to-digital (“A/D”) converter 44 .
  • the A/D converter 44 converts this signal into digital data that can be analyzed by a processor 46 to identify the presence of a vulnerable plaque 12 hidden beneath the arterial wall 14 .
  • FIG. 3 shows an optical bench 48 in which are seated the collection fiber 20 and the delivery fiber 18 .
  • the optical bench 48 is seated in a recess 50 between first and second side walls 52 A-B of the distal end of a housing 54 .
  • the housing 54 is in turn coupled to the distal end of the torque cable 28 .
  • the recess 50 is just wide enough to enable the collection fiber 20 and the delivery fiber 18 to nestle adjacent to each other.
  • a floor 56 extending between the first and second side walls 52 A-B and across the recess 50 supports both the collection and delivery fibers 18 , 20 .
  • a portion of the optical bench 48 forms a frustum 58 .
  • the frustum 58 extends transversely only half-way across the optical bench 48 , thereby enabling the collection fiber 20 to extend distally past the end of the delivery fiber 18 .
  • the frustum 58 has an inclined surface facing the distal end of the delivery fiber 18 and a vertical surface facing the distal end of the optical bench 48 .
  • the inclined surface forms a 135 degree angle relative to the floor 56 . Other angles can be selected depending on the direction in which light from the delivery fiber 18 is to be directed.
  • a reflective material coating the inclined surface forms a beam re-director, which in this case is a delivery mirror 60 . When light exits axially from the delivery fiber 18 , the delivery mirror 60 intercepts that light and redirects it radially outward to the arterial wall 14 . Examples of other beam re-directors include prisms and diffraction gratings.
  • FIG. 5 which illustrates the spatial distribution of light from the viewpoint of the catheter 16 , shows such a re-entrant zone 70 surrounding an illumination spot 32 .
  • Photons received from within the re-entrant zone 70 are predominantly those that have been scattered from within the arterial wall 14 .
  • the re-entrant zone 70 has an inner circumference 74 and an outer circumference 76 .
  • Between the inner circumference 74 and the illumination spot 32 lies a specular zone 78 .
  • Photons received from the specular zone 78 are predominantly those that have undergone specular reflection. Proceeding radially outward beyond the outer circumference 76 , one comes to a dark zone 80 , where the number of photons of either type is so small as to be immeasurable.
  • the field-of-view 32 should overlap the re-entrant zone 70 to the greatest extent possible. To the extent that the field-of-view 32 extends outside the re-entrant zone 70 , it should extend into the dark zone 80 and away from the specular zone 78 . Modifying the field-of-view with an obstruction Referring back to FIG. 3, the collection fiber 20 extends past the end of the delivery fiber 18 until it terminates at a plane that is coplanar with the vertical face of the frustum 58 .
  • a portion of the optical bench 48 forms an inclined surface extending transversely across the optical bench 48 and making a 135 degree angle relative to the floor 56 .
  • a reflective material coating the inclined surface forms a collection mirror 82 .
  • This collection mirror 82 reflects light incident from the arterial wall 14 into the distal end of the collection fiber 20 .
  • the collection mirror 82 and the collection fiber 20 together form a collection subsystem 84 that collects light from a field-of-view 32 .
  • a delivery-fiber stop 86 molded into the optical bench 48 proximal to the frustum 58 facilitates placement of the delivery fiber 18 at a desired location proximal to the delivery mirror 60 .
  • a collection-fiber stop 88 molded into the optical bench 48 just proximal to the collection mirror 82 facilitates placement of the collection fiber 20 at a desired location proximal to the collection mirror 82 .
  • the collection fiber has an optically transmissive core 90 surrounded by a protective cladding 92 .
  • the collection-fiber stop 88 extends upward from the floor 56 to provide an abutment surface for the collection fiber 20 .
  • a portion of the cladding 92 rests on the abutment surface.
  • the core 90 does not rest on the abutment surface and therefore remains unobstructed.
  • a distal tip assembly 94 configured as shown in FIG. 6 results in a field-of-view 32 shaped like an ellipse 96 with its major axis 98 extending along the radial direction, as shown in FIG. 7.
  • the extent to which the ellipse 96 overlaps the re-entrant zone 70 is one measure of how effective the collection subsystem 84 is at guiding re-entrant light into the collection fiber 20 .
  • the extent of the overlap between the ellipse 96 and the re-entrant zone 70 depends on the eccentricity of the ellipse and its position relative to the re-entrant zone 70 .
  • the eccentricity of the ellipse 96 is governed by the angular orientation of the collection mirror 82 . Its position relative to the re-entrant zone 70 is controlled by varying the position and angle of the delivery mirror 60 relative to the collection mirror 82 .
  • the ellipse 96 is positioned to be tangent to the inner circumference 74 of the re-entrant zone 70 , with its minor axis 100 located radially outward from the point of tangency.
  • FIGS. 8 and 9 show an extended collection-fiber stop 102 forms an abutment surface that extends part-way across the core 90 of the collection fiber.
  • the occluded portion of the core 90 is bounded by a chord extending across the core 90 and by an arc that forms part of the boundary between the core 90 and the cladding 92 .
  • the resulting modified field-of-view is a truncated ellipse 106 having a base 108 , as shown in FIG. 10.
  • a dotted line 110 outlines a portion 112 of the ellipse truncated by the extended collection-fiber stop 102 .
  • the truncated ellipse 106 is positioned such that the base 108 of the truncated ellipse 106 is tangent to the inner circumference 74 of the re-entrant zone 70 .
  • the overlap between the truncated ellipse 106 and the re-entrant zone 70 in FIG. 10 is greater than the overlap between the full ellipse 96 and the re-entrant zone 70 in FIG. 7.
  • the extent to which these overlaps differ represents an increase in the number of photons gathered from the re-entrant zone 70 .
  • FIGS. 11 and 12 Other beam-shaping structures can be used to prevent light from illuminating the entire core 90 and to thereby shape the field-of-view 32 .
  • a tab 118 having a curved distal tip 119 protrudes vertically upward from the collection-fiber stop 88 and obstructs part of the core 90 .
  • FIGS. 14 and 15 Another example, shown in FIGS. 14 and 15, is an occulting disk 122 mounted on a post 124 that protrudes from the collection-fiber stop 88 .
  • the post 124 supports the occulting disk 122 so that its center coincides with the center of the core 90 .
  • the diameter of the occulting disk 122 is slightly smaller than the diameter of the core 90 .
  • the difference between the diameter of the occulting disk 122 and that of the core 90 is selected to provide an annular field-of-view that closely matches the size and shape of the re-entrant zone 70 .
  • Structures that effectively block light from entering a portion of the collection fiber need not be adjacent to the collection fiber 20 , as shown in FIGS. 11 - 12 and in FIGS. 14 - 15 .
  • such structures can be placed anywhere along the optical path between the collection fiber 20 and the arterial wall 14 .
  • a beam-shaping structure that effectively obstructs a portion of the core 90 can be a mask 125 formed directly on the collection mirror 82 , as shown in FIG. 16.
  • Another example of such a structure is a perforated shell 127 rotationally coupled to the torque cable 28 , as shown in FIG. 17.
  • the perforated shell 127 has a delivery aperture 129 to permit light from the delivery fiber 18 to pass through the shell 127 unimpeded, and a collection aperture 131 shaped to block a portion of the light incident on the collection mirror 82 .
  • an opaque band 133 on a transparent distal tip 135 of the stationary sheath 26 is positioned to obscure a portion of the collection mirror 82 .
  • the band 131 extends circumferentially around the sheath so that the collection mirror 82 is obscured as the torque cable 28 rotates the collection mirror 82 .
  • any of the foregoing beam-shaping structures can have an edge that is modified to diffract light incident thereon in a manner that causes the field-of-view to have a pre-selected geometry.
  • Such an edge can be formed by providing protrusions or indentations having a dimension on the order of the wavelength of light to be observed.
  • the beam-shaping function of the foregoing obstructions can also be achieved by providing an optical system in optical communication with the collection mirror 82 .
  • Such an optical system can include a collection mirror 82 with a curved surface, a lens assembly, or both.
  • the collection mirror 82 has a cylindrical surface rather than a planar surface.
  • the resulting field-of-view for the configuration shown in FIG. 19 is an ellipse 126 having an aspect ratio closer to unity, as shown in FIG. 20.
  • curved surfaces can result in fields-of-view or alternatively an ellipse 128 in which it is the minor axis of an ellipse 128 , rather than the major axis, that extends radially, as shown in FIG. 21.
  • Curved surfaces other than a cylindrical surface can also be used to shape the field-of-view to more closely approximate the shape of the re-entrant zone 70 .
  • the curved surface can be a conic surface, such as a paraboloid, a hyperboloid, or an ellipsoid.
  • the surface can be a spherical surface.
  • Optical elements other than reflecting surfaces can also be used to shape the field-of-view.
  • a lens assembly 130 disposed in optical communication with the collection fiber 20 provides control over the shape of the field-of-view.
  • the lens assembly 130 can include one or more discrete lenses.
  • One or more lenses in the lens assembly can have a suitably curved surface.
  • Another lens suitable for use in a lens assembly is a GRIN (graduated index of refraction) lens having a spatially varying index of refraction.
  • the lens assembly 130 need not be composed of discrete lenses but can instead include a lens that is integral with the distal end of the collection fiber 20 .
  • Such a lens 132 an example of which is shown in FIG. 22, can be made by shaping the distal end of the collection fiber 20 so that it has the desired optical characteristics.
  • the beam-shaping function provided by the foregoing examples of optical systems can also be provided by a diffracting element 134 placed along the optical path, as shown in FIG. 23.
  • diffracting elements 134 include diffraction gratings, amplitude gratings, spatial light modulators, and holographic gratings.
  • the diffracting element can be a transmissive or reflective.
  • a transmissive diffracting element 134 can be placed anywhere along the optical path traversed by the collection beam, either integrated onto the distal end of the collection fiber 20 , as shown in FIG. 23, or mounted separately on the optical path, either between the collection fiber 20 and the mirror 82 as shown in FIG. 23, or between the collection mirror 82 and the arterial wall.
  • a reflective diffracting element 134 can be integrated directly onto the surface of the collection mirror 82 as shown in FIG. 24.
  • the surfaces of the delivery and collection mirrors 60 , 82 can be coated with a reflective coating, such as gold, silver or aluminum. These coatings can be applied by known vapor deposition techniques. Alternatively, for certain types of plastic, a reflective coating can be electroplated onto those surfaces. Or, the plastic itself can have a reflective filler, such as gold or aluminum powder, incorporated within it.
  • a reflective coating such as gold, silver or aluminum.
  • the optical bench 48 is manufactured by injection molding a plastic into a mold. In addition to being simple and inexpensive, the injection molding process makes it easy to integrate the elements of the optical bench 48 into a single monolith and to fashion structures having curved surfaces.
  • suitable plastics include liquid crystal polymers (LCPs), polyphenylsulfone, polycarbonate, acrylonitrile butadiene-styrene (“ABS”), polyamide (“NYLON”), polyethersulfone, and polyetherimide.
  • the optical bench can be manufactured by micro-machining plastic or metal, by lithographic methods, by etching, by silicon optical bench fabrication techniques, or by injection molding metal. Materials other than plastics can be used to manufacture the housing 54 and the optical bench 48 . Such materials include metals, quartz or glass, and ceramics.
  • the floor 56 in the illustrated embodiment is integral to the housing 54 .
  • the floor 56 can also be made part of the optical bench 48 .
  • the housing 54 and the optical bench 48 are manufactured separately and later joined. However, the housing 54 and the optical bench 48 can also be manufactured together as a single unitary structure.
  • the distal tip assembly 94 is inserted into a blood vessel, typically an artery, and guided to a location of interest. Light is then directed into the delivery fiber 18 . This light exits the delivery fiber 18 at its distal tip, reflects off the delivery mirror 60 in a direction away from the plane containing the delivery and collection fibers 18 , 20 , and illuminates an illumination spot 32 on the wall of the artery. Light penetrating the arterial wall 14 is then scattered by structures within the wall. Some of this scattered light re-enters the blood vessel and impinges on the plane and onto the collection mirror 82 . The collection mirror 82 directs this light into the collection fiber 20 .
  • light incident on the wall 14 can stimulate fluorescence from structures on or within the wall 14 .
  • the portion of this fluorescent light that is incident on the collection mirror 82 is directed into the collection fiber 20 .

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
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  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
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  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Physiology (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Instruments For Viewing The Inside Of Hollow Bodies (AREA)
  • Endoscopes (AREA)
US10/289,741 2002-11-07 2002-11-07 Spectroscope with modified field-of-view Abandoned US20040092829A1 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
US10/289,741 US20040092829A1 (en) 2002-11-07 2002-11-07 Spectroscope with modified field-of-view
AU2003291401A AU2003291401A1 (en) 2002-11-07 2003-11-07 Spectroscope with modified field-of-view
PCT/US2003/035692 WO2004043251A1 (fr) 2002-11-07 2003-11-07 Spectroscope possedant un champ de vision modifie
JP2004551957A JP2006505360A (ja) 2002-11-07 2003-11-07 改良された視野を有する分光器
EP03768797A EP1558127A4 (fr) 2002-11-07 2003-11-07 Spectroscope possedant un champ de vision modifie
US11/772,887 US7873406B2 (en) 2002-11-07 2007-07-03 Spectroscope for recovering light from re-entrant zone of arterial wall
US12/641,811 US20100160792A1 (en) 2002-11-07 2009-12-18 Spectroscope With Modified Field-of-View
JP2010000840A JP2010142649A (ja) 2002-11-07 2010-01-06 改良された視野を有する分光器

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10/289,741 US20040092829A1 (en) 2002-11-07 2002-11-07 Spectroscope with modified field-of-view

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US7873406B2 (en) 2011-01-18
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JP2006505360A (ja) 2006-02-16
EP1558127A1 (fr) 2005-08-03
AU2003291401A1 (en) 2004-06-03
US20100160792A1 (en) 2010-06-24
JP2010142649A (ja) 2010-07-01

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