US20030162818A1

US20030162818A1 - Acylsulfonamide derivative

Info

Publication number: US20030162818A1
Application number: US10/377,726
Authority: US
Inventors: Hiroshi Ikawa; Masato Nishimura; Keiji Okada; Takashi Nakamura
Original assignee: Ajinomoto Co Inc
Current assignee: Ajinomoto Co Inc
Priority date: 1997-09-26
Filing date: 2003-03-04
Publication date: 2003-08-28
Also published as: US6555584B1

Abstract

This invention provides a novel acylsulfonamide derivative which can be used as an ACC activity inhibitor effective for the treatment of visceral fat syndrome that becomes the risk-factor of diseases of adult people such as myocardial infarction, cerebral infarction and diabetes.

Particularly, it relates to an acylsulfonamide derivative represented by a general formula 1

wherein R¹is substituted/unsubstituted C₁-C₁₂alkyl or alkoxy group or substituted/unsubstituted C₂-C₁₂alkenyl or alkynyl group, R²is hydrogen atom, hydroxyl group, mercapto group, substituted/unsubstituted C₁-C₆alkoxy or alkylthio group, nitro group, halogen atom, trichloromethyl group, trifluoromethyl group or cyano group, R³is substituted/unsubstituted C₁-C₂₀alkyl or alkoxy group, substituted/unsubstituted C₂-C₂₀alkenyl or alkynyl group, substituted/unsubstituted aromatic hydrocarbon or aromatic heterocyclic group, substituted amino group, substituted/unsubstituted C₂-C₂₀alkenyloxy or alkynyloxy group or R⁴O— (wherein R⁴is substituted/unsubstituted aromatic hydrocarbon or aromatic heterocyclic group), Y is —CH═CH—, —N═CH—, —CH═N—, sulfur or oxygen, and ring A is aromatic hydrocarbon, aromatic heterocyclic ring or cyclic alkyl group.

Description

FIELD OF THE INVENTION

This invention relates to acylsulfonamide derivatives, more particularly to a novel acylsulfonamide derivative which has the activity to inhibit acetyl-CoA carboxylase (also to be referred to as “ACC” hereinafter).

BACKGROUND ART

It has been revealed in recent years that excess accumulation of neutral fat, particularly triglyceride, in visceral fat tissue is an important risk-factor for various diseases such as hyperlipemia, hypertension, arteriosclerosis, myocardial infarction and glucose tolerance abnormality. That is, it is considered that fatty acid synthesis is activated in the visceral fat tissue, and the fatty acids accelerate insulin resistance when released in the portal vein and are further incorporated into the liver and used as materials of triglyceride which is then released into blood plasma to cause hypertriglyceridemia.

On the other hand, ACC is an enzyme which catalyzes synthesis of malonyl-CoA from acetyl-CoA and is a rate-limiting enzyme in the biosynthesis of long chain fatty acids. Also, it is known that the malonyl-CoA itself synthesized from acetyl-CoA by the action of ACC controls carnitine acyltransferase which is concerned in the consumption of free long chain fatty acids as energy source. In addition, it is considered that activation of ACC is concerned in the activation of fatty acid synthesis in the visceral fat tissue. In consequence, an agent capable of inhibiting the ACC activity inhibits biosynthesis of long chain fatty acids in the living body, while simultaneously accelerating their metabolism, and thereby reduces the amount of long chain fatty acids in the living body and inhibits biosynthesis of triglyceride as a result, so that it has a possibility as a drug for the treatment and prevention of various diseases caused by the accumulation of visceral fat.

SUMMARY OF THE INVENTION

Based on such a viewpoint, the present inventors have conducted intensive studies with the aim of finding an ACC activity inhibitor effective for the treatment of visceral fat syndrome which becomes the risk-factor for diseases of adult people such as myocardial infarction, cerebral infarction and diabetes, and have newly found as a result of the efforts that excellent ACC inhibition activity can be found in acylsulfonamide derivatives represented by a general formula (I) shown in the following. The invention has been accomplished based on this finding. Thus, the invention contemplates providing a novel acylsulfonamide derivative and a medicament, particularly an ACC activity inhibitor, which uses such compound as the active ingredient.

Accordingly, an object of the invention is to provide an acylsulfonamide derivative represented by a general formula 1

wherein R ¹represents a substituted or unsubstituted C₁-C₁₂alkyl group, a substituted or unsubstituted C₂-C₁₂alkenyl group, a substituted or unsubstituted C₂-C₁₂alkynyl group or a substituted or unsubstituted C₁-C₁₂alkoxy group, R²represents a hydrogen atom, a hydroxyl group, a mercapto group, a substituted or unsubstituted C₁-C₆alkoxy group, a substituted or unsubstituted C₁-C₆alkylthio group, a nitro group, a halogen atom, a trichloromethyl group, a trifluoromethyl group or a cyano group, R³represents a substituted or unsubstituted C₁-C₂₀alkyl group, a substituted or unsubstituted C₂-C₂₀alkenyl group, a substituted or unsubstituted C₂-C₂₀alkynyl group, a substituted or unsubstituted aromatic hydrocarbon group, a substituted or unsubstituted aromatic heterocyclic group, a substituted amino group, a substituted or unsubstituted C₁-C₂₀alkoxy group, a substituted or unsubstituted C₂-C₂₀alkenyloxy group, a substituted or unsubstituted C₂-C₂₀alkynyloxy group or a group represented by R⁴O— (wherein R⁴represents a substituted or unsubstituted aromatic hydrocarbon group or a substituted or unsubstituted aromatic heterocyclic group), Y is a group represented by —CH═CH—, —N═CH— or —CH═N—, sulfur atom or oxygen atom, and ring A represents a substituted or unsubstituted aromatic hydrocarbon group, a substituted or unsubstituted aromatic heterocyclic group or a substituted or unsubstituted cyclic alkyl group.

Other objects and advantages of the invention will be made apparent as the description progresses.

DETAILED DESCRIPTION OF THE INVENTION

The acylsulfonamide derivatives represented by the general formula (I), to be provided by the invention, are novel rounds which have not been known to date, and the presence of ACC activity inhibition action in these compounds has not been known either. However, as is evident from the results of pharmacological tests which will be described later, it was revealed that these compounds have excellent ACC activity inhibition action. In consequence, these compounds are markedly useful particularly as the ACC activity inhibitor effective for the treatment of visceral fat syndrome that becomes the risk-factor for diseases of adult people such as myocardial infarction, cerebral infarction and diabetes. Thus, as its another embodiment, the invention also provides a medicament which uses the acylsulfonamide derivative represented by the general formula (I) as an active ingredient.

The acylsulfonamide derivatives to be provided by the invention are described in detail in the following. The term “C ₁-C₁₂alkyl group” as used herein means any one of straight, branched and cyclic groups, and its examples include methyl, ethyl, n-propyl, 1-methylethyl, cyclopropyl, n-butyl, 2-methylpropyl, 1-methylpropyl, 1,1-dimethylethyl, cyclobutyl, n-pentyl, 1-methylbutyl, 2-methylbutyl, 3-methylbutyl, cyclopentyl, 2,2-dimethylpropyl, n-hexyl, 1-methylpentyl, 2-methylpentyl, 4-methylpentyl, 1-ethylbutyl, 2-ethylbutyl, 3,3-dimethylbutyl, cyclohexyl, n-heptyl, 1-methylhexyl, 2-methylhexyl, 5-methylhexyl, 4,4-dimethylpentyl, 1-propylbutyl, 2-ethylpentyl, cyclohexylmethyl, 1,1-diethylpropyl, cycloheptyl, n-octyl, 1-methylheptyl, 6-methylheptyl, 1-ethylhexyl, 2-ethylhexyl, 2-cyclohexylethyl, 5,5-dimethylhexyl, cyclooctyl, n-nonyl, 1-methyloctyl, 7-methyloctyl, 6,6-dimethylheptyl, n-decyl, 1-methylnonyl, 8-dimethylnonyl, 7,7-dimethyloctyl, n-undecyl, 1-methyldecyl, 9-methyldecyl, 8,8-dimethylnonyl, n-dodecyl, 1-methylundecyl, 10-methylundecyl, 5-methylundecyl and 9,9-dimethyldecyl. Also, these alkyl groups may further have various substituents. Examples of such substituents include halogen atoms such as chlorine, bromine, iodine and fluorine, nitro group, amino group, cyano group, hydroxyl group, alkoxy group, thiol group, trichloromethyl group, trifluoromethyl group, aromatic hydrocarbon groups such as phenyl group and naphthyl group, and aromatic heterocyclic groups such as thienyl, furyl and pyridyl. In addition, these aromatic hydrocarbon groups and aromatic heterocyclic groups may also have substituents such as halogen atom, alkyl group, alkoxy group, nitro group, amino group, cyano group, hydroxyl group and thiol group.

The term “C ₁-C₂₀alkyl group” as used herein means any one of straight, branched and cyclic groups, and its examples include dodecyl, tetradecyl, pentadecyl, hexadecyl, heptadecyl, octadecyl, nonadecyl and eicosyl, in addition to those which are exemplified regarding the “C₁-C₁₂alkyl group”. These alkyl groups may further have various substituents. The same substituents of the “C₁-C₂₀alkyl group” can be exemplified as such substituents.

The term “substituted or unsubstituted aromatic hydrocarbon group” means an aromatic hydrocarbon group which is monocyclic or polycyclic and may have one or more of various substituents on the ring, and its examples include phenyl, methylphenyl, dimethylphenyl, methoxyphenyl, dimethoxyphenyl, nitrophenyl, dinitrophenyl, chlorophenyl, dichlorophenyl, bromophenyl, dibromophenyl, iodophenyl, fluorophenyl, trifluoromethylphenyl, aminophenyl, hydroxyphenyl, mercaptophenyl, α-naphthyl and β-naphthyl.

The term “substituted or unsubstituted aromatic heterocyclic group” means a five- or six-membered ring group containing at least one hetero atom such as nitrogen atom, sulfur atom or oxygen atom as a ring-constituting atom, which may be condensed with benzene ring(s) and may have one or more of various substituents on the ring, and its examples include pyridyl, furyl, thienyl, indolyl, quinolyl, isoquinolyl, benzofuranyl, benzothienyl, imidazolyl, benzimidazolyl, thiazolyl, oxazolyl, pyrazolyl, pyrimidyl, pyrazinyl, isoxazolyl, isoindolyl and pyrrolyl.

The term “C ₂-C₁₂alkenyl group” means a linear or branched group, and its examples include 1-methyl-1-propenyl, 1-methyl-2-propenyl, 2-methyl-2-propenyl, ethenyl, 1-methylethenyl, 1-propenyl, 2-propenyl, 1-butenyl, 2-butenyl, 2-pentenyl, 1-pentenyl, 3-methylbutenyl, 1,3-butanedienyl, 1-hexenyl, 2-hexenyl, 3,3-dimethyl-1-butenyl, 4,4-dimethyl-1-pentenyl, 1,3-pentanedienyl, 1,3-hexanedienyl, 2-cyclohexylethenyl, octenyl, nonenyl, decenyl, undecenyl and dodecenyl. These alkenyl groups may further have various substituents. The same substituents of the “C₁-C₁₂alkyl group” can be exemplified as such substituents.

The term “C ₂-C₂₀alkenyl group” means any one of linear, branched or cyclic groups, and its examples include tridecenyl, tridecadienyl, tetradecenyl, tetradecadienyl, pentadecenyl, pentadecadienyl, pentadecatrienyl, hexadecenyl, hexadecadienyl, hexadecatrienyl, heptadecenyl, heptadecadienyl, heptadecatrienyl, octadecenyl, octadecadienyl, octadecatrienyl, nonadecenyl, nonadecadienyl, nonadecatrienyl, eicosenyl, eicosadienyl and eicosatrienyl, in addition to those which are exemplified regarding the “C₂-C₁₂alkyl group”. These alkenyl groups may further have various substituents. The same substituents of the “C₁-C₁₂alkyl group” can be exemplified as such substituents.

The term “C ₂-C₁₂alkynyl group” means a linear or branched group, and its examples include 1-propynyl, 2-propynyl, 1-methyl-2-propynyl, 1-ethyl-2-propynyl, ethynyl, 1-butynyl, 2-butynyl, 1,3-butadiynyl, 1-pentynyl, 2-pentynyl, 1,3-pentadiynyl, 1-hexynyl, 2-hexynyl and 1,3-hexadiynyl. These groups may further have various substituents. The same substituents of the “C₁-C₁₂alkyl group” can be exemplified as such substituents.

The term “C ₂-C₂₀alkynyl group” means any one of linear, branched and cyclic groups, and its examples include tridecynyl, tridecadiynyl, tetradecynyl, tetradecadiynyl, pentadecynyl, pentadecadiynyl, pentadecatriynyl, hexadecynyl, hexadecadiynyl, hexadecatriynyl, heptadecnyl, heptadecadiynyl, heptadecatriynyl, octadecynyl, octadecadiynyl, octadecatriynyl, nonadecynyl, nonadecadiynyl, nonadecatriynyl, eicosynyl, eicosadiynyl and eicosatriynyl, in addition to those which are exemplified regarding the “C₂-C₁₂alkyl group”. These alkenyl groups may further have various substituents. The same substituents of the “C₁-C₁₂alkyl group” can be exemplified as such substituents.

The term “substituted amino group” means a group in which its nitrogen atom is substituted by one or two of a substituted or unsubstituted C ₁-C₂₀alkyl group, a substituted or unsubstituted C₂-C₂₀alkenyl group, a substituted or unsubstituted C₂-C₂₀alkynyl group, a substituted or unsubstituted aromatic hydrocarbon group and a substituted or unsubstituted aromatic heterocyclic group, and the alkyl group together with the binding nitrogen atom may form a five- to seven-membered saturated heterocyclic ring which may contain nitrogen atom, oxygen atom or sulfur atom. Examples of this substituted amino group include methylamino, ethylamino, propylamino, butylamino, pentylamino, hexylamino, dimethylamino, diethylamino, dipropylamino, 2-propenylamino, 2-butenylamino, 3-butenylamino, 1-pyrrolidinyl, piperidino, 1-piperazinyl, morpholino, thiomorpholino, perhydroazepinyl, phenylamino, naphthylamino, pyridylamino, furylamino and thienylamino.

The term “C ₁-C₁₂alkoxy group” means an alkyl-substituted oxy group wherein the alkyl group is as described in the foregoing, and its examples include methoxy, ethoxy, n-propoxy, 1-methylethoxy, n-butoxy, 2-methylpropoxy, 1-methylpropoxy, 2-methyl-2-propoxy, n-pentyloxy, 3-methylbutoxy, n-hexyloxy, 4-methylpentoxy, n-pentyloxy, n-octyloxy, n-nonyloxy, n-decyloxy and n-undecyloxy. These alkyl groups may further have various substituents. The same substituents of the “C₁-C₁₂alkyl group” can be exemplified as such substituents.

The term “C ₁-C₂₀alkoxy group” means any one of linear, branched and cyclic groups, and its examples include tridecyloxy, tetradecyloxy, pentadecyloxy, hexadecyloxy, heptadecyloxy, octadecyloxy, nonadecyloxy and eicosyloxy, in addition to those which are exemplified regarding the “C₁-C₁₂alkoxy group”. These alkoxy groups may further have various substituents. The same substituents of the “C₁-C₁₂alkyl group” can be exemplified as such substituents.

The term “C ₁-C₆alkylthio group” means an alkyl-substituted thio group wherein the alkyl group is as described in the foregoing, and its examples include methylthio, ethylthio, n-propylthio, 1-methylethylthio, n-butylthio, 2-methylpropylthio, 1-methylpropylthio, 2-methyl-2-propylthio, n-pentylthio, 3-methylbutylthio, n-hexylthio and 4-methylpentylthio. These alkylthio groups may further have various substituents. The same substituents of the “C₁-C₁₂alkyl group” can be exemplified as such substituents.

In the acylsulfonamide derivatives represented by the general formula (I), which are provided by the invention, the ring shown by A is the aromatic hydrocarbon group or aromatic heterocyclic group described in the foregoing. As the substitution mode of these groups, it is desirable that the acylsulfonamide side chain and amide side chain have their substitution sites at the 1,2-position, or at the 1,1-position when A is a cyclic alkyl group.

Also, in the acylsulfonamide derivatives represented by the general formula (I), it is desirable that R ¹is a C₁-C₄alkyl group having a substituted or unsubstituted aromatic hydrocarbon group or a substituted or unsubstituted aromatic heterocyclic group as a substituent, a C₂-C₄alkenyl group having a substituted or unsubstituted aromatic hydrocarbon group or a substituted or unsubstituted aromatic heterocyclic group as a substituent, a C₂-C₄alkynyl group having a substituted or unsubstituted aromatic hydrocarbon group or a substituted or unsubstituted aromatic heterocyclic group as a substituent or a C₁-C₄alkoxy group having a substituted or unsubstituted aromatic hydrocarbon group or a substituted or unsubstituted aromatic heterocyclic group as a substituent.

Also, in the acylsulfonamide derivatives represented by the general formula (I), it is desirable that R ¹is an unsubstituted C₅-C₁₂alkyl group, an unsubstituted C₅-C₁₂alkenyl group, an unsubstituted C₅-C₁₂alkynyl group or an unsubstituted C₅-C₁₂alkoxy group.

The following compounds can be exemplified as the acylsulfonamide derivatives of the invention.

N-[2-(3-Benzyloxybenzamido)benzenesulfonyl]benzamide;

N-[2-(3-benzyloxybenzamido)benzenesulfonyl]acetamide;

N-[2-(3-benzyloxybenzamido)benzenesulfonyl]-4-benzyloxybenzamide;

N-[2-(3-benzyloxybenzamido)benzenesulfonyl]-3-benzyloxybenzamide;

N-[2-(3-benzyloxybenzamido)benzenesulfonyl]-2-benzyloxybenzamide;

N-[2-(4-benzyloxybenzamido)benzenesulfonyl]-4-trifluoromethylbenzamide;

N-[2-(3-benzyloxybenzamido)benzenesulfonyl]-4-trifluoromethylbenzamide;

N-[2-(3-benzyloxybenzamido)benzenesulfonyl]-4-methoxybenzamide;

N-[2-(3-benzyloxybenzamido)benzenesulfonyl]-4-nitrobenzamide;

N-[2-(4-phenylethynylbenzamido)benzenesulfonyl]-3-benzyloxybenzamide;

N-[2-[4-(2-phenyl-(E)-ethenyl)benzamido]benzenesulfonyl]-4-trifluoromethylbenzamide;

N-[2-(4-phenylethynylbenzamido)benzenesulfonyl]-3-benzyloxybenzamide;

N-[2-(4-phenylethynylbenzamido)benzenesulfonyl]-4-trifluoromethylbenzamide;

N-[2-(4-phenylethynylbenzamido)benzenesulfonyl]-4-nitrobenzamide;

N-[2-(3-benzyloxybenzamido)benzenesulfonyl]-3,4-difluorobenzamide;

N-[2-(3-benzyloxybenzamido)benzenesulfonyl]-3,4,5-trifluorobenzamide;

N-[2-(3-benzyloxybenzamido)benzenesulfonyl]hexanamide;

N-[2-(3-benzyloxybenzamido)benzenesulfonyl]decanamide;

N-[2-(3-benzyloxybenzamido)benzenesulfonyl]dodecanamide;

N-[2-(3-benzyloxybenzamido)benzenesulfonyl]cyclohexanamide;

N-[2-(3-benzyloxybenzamido)benzenesulfonyl]-3-benzyloxy-5-nitrobenzamide;

N-[2-(3-benzyloxybenzamido)benzenesulfonyl]-3-benzyloxy-5-trifluoromethylbenzamide;

N-[2-(3-benzyloxybenzamido)benzenesulfonyl]-3-benzyloxy-5-chlorobenzamide;

N-[2-(3-benzyloxybenzamido)benzenesulfonyl]-3-benzyloxy-5-fluorobenzamide;

N-[2-(3-benzyloxybenzamido)benzenesulfonyl]-3-benzyloxy-4-nitrobenzamide;

N-[2-(3-benzyloxybenzamido)benzenesulfonyl]-3-benzyloxy-4-trifluoromethylbenzamide;

N-[2-(3-benzyloxybenzamido)benzenesulfonyl]-3-benzyloxy-4-chlorobenzamide;

N-[2-(3-benzyloxybenzamido)benzenesulfonyl]-3-benzyloxy-4-fluorobenzamide;

N-[2-(4-phenylethynylbenzamido)pyridinesulfonyl]-4-nitrobenzamide;

N-[2-(4-phenylethynylbenzamido)pyrazinesulfonyl]-4-nitrobenzamide;

N-[2-(3-naphthyloxybenzamido)benzenesulfonyl]butanamide;

N-[2-(3-naphthylmethoxybenzamido)benzenesulfonyl]butanamide;

N-[2-(3-furyloxybenzamido)benzenesulfonyl]butanamide;

N-[2-(3-furylmethoxybenzamido)benzenesulfonyl]butanamide;

N-[2-(3-thienyloxybenzamido)benzenesulfonyl]butanamide;

N-[2-(3-thienylmethoxybenzamido)benzenesulfonyl]butanamide;

N-[2-(3-pyridyloxybenzamido)benzenesulfonyl]butanamide;

N-[2-(3-pyridylmethoxybenzamido)benzenesulfonyl]butanamide;

N-[2-(3-phenyloxybenzamido)benzenesulfonyl]butanamide;

N-[2-(3-benzyloxybenzamido)benzenesulfonyl]butanamide;

N-[2-(3-benzyloxybenzamido)benzenesulfonyl]pentanamide;

N-[2-(3-benzyloxybenzamido)benzenesulfonyl]heptanamide;

N-[2-(3-benzyloxybenzamido)benzenesulfonyl]octanamide;

N-[2-(3-benzyloxybenzamido)benzenesulfonyl]nonanamide;

N-[2-(3-benzyloxybenzamido)benzenesulfonyl]decanamide;

N-[2-(3-benzyloxybenzamido)benzenesulfonyl]dodecanamide;

N-[2-(3-benzyloxybenzamido)benzenesulfonyl]tetradecanamide;

N-[2-(4-benzyloxybenzamido)benzenesulfonyl]butanamide;

N-[2-(4-benzyloxybenzamido)benzenesulfonyl]pentanamide;

N-[2-(4-benzyloxybenzamido)benzenesulfonyl]heptanamide;

N-[2-(4-benzyloxybenzamido)benzenesulfonyl]octanamide;

N-[2-(4-benzyloxybenzamido)benzenesulfonyl]nonanamide;

N-[2-(4-benzyloxybenzamido)benzenesulfonyl]decanamide;

N-[2-(4-benzyloxybenzamido)benzenesulfonyl]dodecanamide;

N-[2-(4-benzyloxybenzamido)benzenesulfonyl]tetradecanamide;

N-[2-(3-benzyloxybenzamido)benzenesulfonyl]hexadecanamide;

N-[2-(3-benzyloxybenzamido)benzenesulfonyl]octadecanamide;

N-[2-(3-benzyloxybenzamido)benzenesulfonyl]pentafluorobenzamide;

N-[2-(3-benzyloxybenzamido)benzenesulfonyl]eicosanamide;

N-[2-(3-benzyloxybenzamido)benzenesulfonyl]-2,4-difluorobenzamide;

N-[2-[3-(4-t-butylbenzyloxy)benzamido]benzenesulfonyl]pivalamide;

N-[2-[3-(4-t-butylbenzyloxy)benzamido]benzenesulfonyl]cinnamamide;

N-[2-(3-benzyloxybenzamido)benzenesulfonyl]oleinamide;

N-[2-(3-benzyloxybenzamido)benzenesulfonyl]linolamide;

N-[2-(3-benzyloxy-4-nitrobenzamido)benzenesulfonyl]decanamide;

N-[2-(4-chloro-3-benzyloxybenzamido)benzenesulfonyl]decanamide;

N-[2-(3-benzyloxy-4-hydroxybenzamido))benzenesulfonyl]decananide;

N-[2-(3-benzyloxy-4-cyanobenzamido)benzenesulfonyl]decananide;

N-[2-(3-benzyloxy-4-methoxybenzamido)benzenesulfonyl]decanamide;

N-[2-[3-(4-chlorobenzyloxy)benzamido]benzenesulfonyl]acetamide;

N-[2-[3-(4-chlorobenzyloxy)benzamido]benzenesulfonyl]hexanamide;

N-[2-[3-(4-chlorobenzyloxy)benzamido]benzenesulfonyl]decanamide;

N-[2-[3-(4-nitrobenzyloxy)benzamido]benzenesulfonyl acetamide;

N-[2-[3-(4-nitrobenzyloxy)benzamido]benzenesulfonyl]hexanamide;

N-[2-[3-(4-nitrobenzyloxy)benzamido]benzenesulfonyl]decanamide;

N-[2-[3-(4-methoxybenzyloxy)benzamido]benzenesulfonyl]acetamide;

N-[2-[3-(4-methoxybenzyloxy)benzamido]benzenesulfonyl]hexanamide;

N-(2-[3-(4-methoxybenzyloxy)benzamido]benzenesulfonyl]decanamide;

N-[2-(3-cyclohexylmethoxybenzamido)benzenesulfonyl]acetamide;

N-[2-(3-cyclohexylmethoxybenzamido)benzenesulfonyl]hexanamide;

N-[2-(3-cyclohexylmethoxybenzamido)benzenesulfonyl]decananide;

N-[2-[3-(4-t-butylbenzyloxy)benzamido]benzenesulfonyl]acetamide;

N-[2-[3-(4-t-butylbenzyloxy)benzamido]benzenesulfonyl]hexanamide;

N-[2-[3-(4-t-butylbenzyloxy)benzamido]benzenesulfonyl]decanamide;

N-[2-[3-(4-trifluoromethylbenzyloxy)benzamido]benzenesulfonyl]acetamide;

N-[2-[3-(4-trifluoromethylbenzyloxy)benzamido]benzenesulfonyl]hexanamide;

N-[2-[3-(4-trifluoromethylbenzyloxy)benzamido]benzenesulfonyl]decanamide;

N-[2-(3-heptyloxybenzamido)benzenesulfonyl]acetamide;

N-[2-(3-octyloxybenzamido)benzenesulfonyl]acetamide;

N-[2-(3-decyloxybenzamido)benzenesulfonyl]acetamide;

N-[2-(3-heptyloxybenzamido)benzenesulfonyl]hexanamide;

N-[2-(3-heptyloxybenzamido)benzenesulfonyl]decanamide;

N-[2-(4-phenylethynylbenzamido)benzenesulfonyl]acetamide;

N-[2-[4-(1-hexynyl)benzamido]benzenesulfonyl]acetamide;

N-[2-[4-(1-hexynyl)benzamido]benzenesulfonyl]hexanamide;

N-[2-[4-(1-octynyl)benzamido]benzenesulfonyl]acetamide;

N-[2-[4-(1-octynyl)benzamido]benzenesulfonyl]hexanamide;

N-[2-[4-(3,3-dimethylbutan-1-yl)benzamido]benzenesulfonyl]acetamide;

N-[2-[4-(3,3-dimethylbutan-1-yl)benzamido]benzenesulfonyl]hexanamide;

N-[2-[4-(1-hexenyl)benzamido]benzenesulfonyl]acetamide;

N-[2-[4-(1-hexenyl)benzamido]benzenesulfonyl]hexanamide;

N-[2-[4-(1-octenyl)benzamido]benzenesulfonyl]acetamide;

N-[2-[4-(1-octenyl)benzamido]benzenesulfonyl]hexanamide;

N-[2-[4-(3,3-dimethylbutan-1-enyl)benzamido]benzenesulfonyl]acetamide;

N-[2-[4-(3,3-dimethylbutan-1-enyl)benzamido]benzenesulfonyl]hexanamide;

N-[2-(4-phenylethynylbenzamido)benzenesulfonyl]hexamamide;

N-[2-(4-phenylethynylbenzamido)benzenesulfonyl]decanamide;

N-[2-(4-phenylethynylbenzamido)benzenesulfonyl]pivalamide;

3-methyl-N-[2-(4-phenylethynylbenzamido)benzenesulfonyl]-2-butenamide;

trans-N-[2-(4-phenylethynylbenzamido)benzenesulfonyl]-2,4-hexadienamide;

trans-N-[2-(4-phenylethynylbenzamido)benzenesulfonyl]-3-hexenamide;

3-benzyloxy-N-[2-[(phenyloxycarbonylamino)sulfonyl]phenyl]benzamide;

3-benzyloxy-N-[2-[[(butylamino)carbonylamino]sulfonyl]phenyl]benzamide; and

3-benzyloxy-N-[2-[[(octylamino)carbonylamino]sulfonyl]phenyl]benzamide.

The acylsulfonamide derivatives of the invention can be produced in accordance, for example, with the following method. This production method can be summarized by the following chemical formulae.

In the above formulae, R ¹, R², R³, Y and ring A are as defined in the foregoing, and X is a halogen atom such as chlorine or bromine, succinimido group or imidazolyl group.

(First step) In this step, a sulfonamide compound represented by the formula (IV) is produced by carrying out condensation reaction of an aminosulfonamide compound represented by the formula (II) with a carboxylic acid represented by the formula (III). This step includes a method in which a condensing agent such as carbonyldiimidazole, dicyclohexylcarbodiimide or 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride is used, a method in which the carboxylic acid represented by the formula (III) is converted into a corresponding acid halide using a halogenation agent such as thionyl chloride or phosphorus pentachloride and then condensed in the presence of an appropriate base and a method in which the carboxylic acid represented by the formula (III) is converted into an acid anhydride using p-toluenesulfonic acid chloride, ethyl chlorocarbonate or pivaloyl chloride and then condensed in the presence of an appropriate base.

In this reaction, it is desirable to use the aminosulfonamide compound represented by the formula (II) and the carboxylic acid represented by the formula (III) in almost equimolar amounts. The reaction temperature and reaction period are not generally limited due, for example, to the kinds of compounds, but the compound of interest can be obtained with a high yield by carrying out the reaction at a temperature of from about 0° C. to about boiling point of the solvent to be used for a period of approximately from 0.1 to 25 hours. Regarding amount of the condensing agent to be used, it is desirable to add the agent in an amount of about 1.2 equivalents based on the carboxylic acid represented by the formula (III).

Organic bases and inorganic bases can be cited as examples of the base to be used, which include alkali metal hydrides such as sodium hydride and potassium hydride; alkali metal hydroxides such as sodium hydroxide and potassium hydroxide; alkali metal carbonates such as sodium carbonate and potassium carbonate; alkali metal bicarbonates such as sodium bicarbonate and potassium bicarbonate; alkali metal alkoxides such as sodium methoxide, sodium ethoxide, potassium methoxide and potassium tert-butoxide; trialkylamines such as trimethylamine and triethylamine; and pyridines such as pyridine, dimethylaminopyridine, picoline and lutidine. It is desirable to use the base in an amount of from 1 to 10 equivalents based on the carboxylic acid compound.

In this step, the reaction can be carried out in an inert solvent, and examples of such a solvent include ethers such as diethyl ether, tetrahydrofuran and dioxane; aromatic hydrocarbons such as benzene, toluene and xylene; hydrocarbons such as cyclopentane and cyclohexane; halogenated hydrocarbons such as dichloromethanea, dichloroethane, trichloroethane and chloroform; nitrites such as acetonitrile and propionitrile; esters such as ethyl acetate; and N,N-dimethylformamide and dimethyl sulfoxide, or their mixtures with water.

(Second step) In this step, an acylsulfonamide sound represented by the formula (I) is produced by allowing a sulfonamide compound represented by the formula (IV) to react with an acyl compound represented by the formula (V) in the presence of a base. In the acyl compound of formula (V) to be used in this step, X is a halogen atom such as chlorine or bromine, succinimido group or imidazolyl group. Regarding the base to be used, the same base used in the first step can be used, and it is desirable to use it in an amount of from 1 to 10 equivalents based on the carboxylic acid compound. In this reaction, it is desirable to use the sulfonamide compound represented by the formula (IV) and the acyl compound represented by the formula (V) in almost equimolar amounts. The reaction temperature and reaction period are not generally limited due, for example, to the kinds of compounds, but the compound of interest can be obtained with a high yield by carrying out the reaction at a temperature of from about 0° C. to about boiling point of the solvent to be used for a period of approximately from 0.1 to 25 hours. The reaction can be carried out in an inert solvent. The same solvent used in the first step can be exemplified as this inert solvent.

By optionally combining these reactions, the acylsulfonamide derivative of interest represented by the general formula (I) can be obtained, and it can be isolated and purified as occasion demands by subjecting the reaction solution to generally used purification means such as filtration, decantation, extraction, washing, solvent evaporation, column or thin layer chromatography, recrystallization and distillation.

When the acylsulfonamide derivative of the invention represented by the formula (I) is administered to human as a medicament, it is desirable to administer its effective amount, e.g., generally from 5 to 30 mg per day, by oral administration by dividing the daily dose into 1 to 3 doses per day, though it varies depending on various conditions such as the age of each patient and symptoms of the disease to be treated. The medicament of the invention can be made into various dosage forms, e.g., oral administration preparations such as tablets, capsules, granules, powders, troches and solutions. These preparations can be obtained by generally known methods. For example, tablets, capsules, granules, powders or troches can be produced by formulating the compound of general formula (I) of the invention in optional combination, for example, with fillers such as starch, mannitol and lactose; binders such as carboxymethylcellulose sodium and hydroxypropylcellulose; disintegrators such as crystalline cellulose and carboxymethylcellulose; lubricants such as talk and magnesium stearate; and fluidity improving agents such as soft silicic anhydride. Also, the medicament of the invention can be used as injections. Regarding their preparation method, the compound may be dispersed or solubilized in advance in an aqueous carrier such as physiological saline using a surface active agent or a dispersing agent, or made into a crystalline or freeze-dried preparation for injection use which can be dispersed or solubilized prior to its use. A pH adjusting agent and a stabilizing agent may be added to the aqueous carrier as optional components. The dose and the route of administration of such injections are not particularly limited, and a safe and necessary amount can be administered in one portion or continuously by intravenous, intraarterial, subcutaneous or intraperitoneal administration, in response to the condition of each disease and characteristics of each patient.

The following describes the invention further in detail with reference to Examples and Pharmacological Test Examples, but the invention is not limited to the following descriptions.

REFERENCE EXAMPLE 1

3-Benzyloxy-N-(2-sulfamoylphenyl)benzamide

[0149]
A benzene (40 ml) solution containing 2 g (8.8 mmol) of 3-benzyloxybenzoic acid and 8 ml of thionyl chloride was heated under reflux for 2 hours and then the solvent was evaporated. A dioxane (10 ml) solution of the resulting residue was added dropwise to a water-dioxane 1:1 (20 ml) solution containing 1.5 g (8.8 mmol) of 2-aminobenzenesulfonamide and 1.62 g (19 mmol) of sodium bicarbonate, and the mixture was stirred at room temperature for 1 hour. After completion of the reaction, dioxane was evaporated, the resulting residue was acidified by adding 1 N HCl under ice-cooling and extracted with ethyl acetate. The extract was washed with water and saturated brine and dried over anhydrous sodium sulfate, and then the solvent was evaporated under a reduced pressure. By recrystallizing the resulting residue from acetonitrile, 2.0 g (yield: 60%) of the title compound was obtained. [0150]
NMR (CDCl[0151] ₃) δ: 4.86 (2H, s), 5.15 (2H, s), 7.18 (1H, dd, J=8 Hz, 1 Hz), 7.26 (1H, ddd, J=8 Hz, 8 Hz, 2 Hz), 7.25-7.48 (6H, m), 7.59 (1H, dd, J=1 Hz, 1 Hz), 7.63 (1H, dd, J=8 Hz, 8 Hz), 7.97 (1H, dd, J=8 Hz, 2 Hz), 8.56 (1H, d, J=8 Hz), 10.03 (1H, s)
IR (ν, cm[0152] ⁻¹, KBr): 1662, 1332, 1151
EI-MS (m/z, %): 382 (M[0153] ⁺, 18), 302 (6), 211 (15), 91 (100)
Melting point: 181-182° C. [0154]

EXAMPLE 1

N-[2-(3-Benzyloxybenzamido)benzenesulfonyl]-3-benzyloxybenzamide

[0155]
A benzene (10 ml) solution containing 600 mg (2.3 mmol) of 3-benzyloxybenzoic acid and 1.5 ml of thionyl chloride was heated under reflux for 2 hours and then the solvent was evaporated. A dioxane (10 ml) solution of the resulting residue was added dropwise to a water-dioxane 1:1 (10 ml) solution containing 248 mg (1.44 mmol) of 2-amino-benzenesulfonamide and 726 mg (5.2 mmol) of potassium carbonate, and the mixture was stirred at room temperature for 3 hours. After completion of the reaction, dioxane was evaporated, the resulting residue was acidified by adding 1 N HCl under ice-cooling and extracted with ethyl acetate. The extract was washed with water and saturated brine and dried over anhydrous sodium sulfate, and then the solvent was evaporated under a reduced pressure. By recrystallizing the resulting residue from acetonitrile, 200 mg (yield: 90%) of the title compound was obtained. [0156]
NMR (CDCl[0157] ₃) δ: 5.01 (2H, s), 5.13 (2H, s), 7.13-7.50 (17H, m), 7.63-7.78 (3H, m), 8.02 (1H, dd, J=8 Hz, 2 Hz), 8.78 (1H, d, J=8 Hz), 8.87 (1H, br-s), 10.59 (1H, s)
IR (ν, cm[0158] ⁻¹, KBr): 1693, 1585, 1340, 1278, 1159, 1029
EI-MS (m/z, %): 592 (M[0159] ⁺, 24), 368 (7), 300 (11), 212 (7), 211 (41), 181 (10), 121 (10)
Melting point: 172-173° C. [0160]

EXAMPLE 2

N-[2-(3-Benzyloxybenzamido)benzenesulfonyl]benzamide

[0161]
In a stream of nitrogen and under ice-cooling, 88 mg (0.78 mmol) of potassium t-butoxide was added to an anhydrous tetrahydrofuran (10 ml) solution containing 300 mg (0.78 mmol) of 2-(3-benzyloxybenzamido)benzenesulfonamide produced in Reference Example 1, and the mixture was stirred for 1 hour. This solution was mixed with 111 mg (0.78 mmol) of benzoyl chloride and stirred at room temperature for 3 hours. After completion of the reaction, this was neutralized by adding an ammonium chloride aqueous solution and then the solvent was evaporated. The resulting residue was extracted with ethyl acetate, washed with water and saturated brine and dried over anhydrous sodium sulfate, and then the solvent was evaporated under a reduced pressure. The resulting residue was purified by a silica gel column chromatography to obtain 247 mg (yield: 65%) of the title compound. [0162]
NMR (CDCl[0163] ₃) δ: 5.15 (2H, s), 7.17-7.46 (10H, m), 7.59 (1H, dd, J=8 Hz, 8 Hz), 7.66-7.76 (5H, m), 8.03 (1H, d, J=8 Hz), 8.78 (1H, d, J=8 Hz), 8.81 (1H, s), 10.61 (1H, s)
IR (ν, cm[0164] ⁻¹, KBr): 3396, 3255, 1687, 1675, 1578, 1529, 1440, 1340, 1303, 1162, 707
EI-MS (m/z, %): 486 (M[0165] ⁺, 10), 365 (6), 303 (8), 302 (5), 212 (4), 211 (16)
Melting point: 201-202° C. [0166]

EXAMPLE 3

N-[2-(3-Benzyloxybenzamido)benzenesulfonyl]acetamide

[0167]
In a stream of nitrogen and under ice-cooling, 162 mg (1.44 mmol) of potassium t-butoxide was added to an anhydrous tetrahydrofuran (10 ml) solution containing 400 mg (1.04 mmol) of 2-(3-benzyloxybenzamido)benzenesulfonamide produced in Reference Example 1, and the mixture was stirred for 1 hour. This solution was mixed with 121 mg (1.54 mmol) of acetyl chloride and stirred at room temperature for 3 hours. After completion of the reaction, this was neutralized by adding an ammonium chloride aqueous solution and then the solvent was evaporated. The resulting residue was extracted with ethyl acetate, washed with water and saturated brine and dried over anhydrous sodium sulfate, and then the solvent was evaporated under a reduced pressure. The resulting residue was purified by a silica gel column chromatography to obtain 160 mg (yield: 35%) of the title [0168]
NMR (DMSO-d[0169] ₆) δ: 1.99 (3H, s), 5.20 (2H, s), 7.28-7.62 (10H, m), 7.76 (1H, dd, J=8 Hz, 8 Hz), 7.95 (1H, dd, J=8 Hz, 1 Hz), 8.41 (1H, dd, J=8 Hz, 1 Hz), 10.45 (1H, s), 12.58 (1H, s)
IR (ν, cm[0170] ⁻¹, KBr): 3342, 3118, 2871, 1708, 1660, 1585, 1531, 1444, 1162, 1029, 862, 752, 694
EI-MS (m/z, %): 424 (M[0171] ⁺, 69), 365 (13), 303 (27), 302 (22), 301 (10), 212 (16), 211 (71), 210 (20), 183 (16)
Melting point: 195-196° C. [0172]

EXAMPLE 4

N-[2-(3-Benzyloxybenzamido)benzenesulfonyl]-4-trifluoromethylbenzamide

[0173]
A 275 mg (0.72 mmol) portion of 2-(3-benzyloxybenzamido)benzenesulfonamide produced in Reference Example 1, 0.24 ml (1.44 mmol) of 4-trifluoromethylbenzyl chloride and 300 mg (2.16 mmol) of potassium carbonate were dissolved in water-dioxane 1:1 (10 ml), and the solution was stirred for 18 hours. The solvent was evaporated, the resulting residue was extracted with ethyl acetate, washed with water and saturated brine and dried over anhydrous sodium sulfate, and then the solvent was evaporated under a reduced pressure. The resulting residue was purified by a silica gel column chromatography to obtain 322 mg (yield: 88%) of the title compound. [0174]
NMR (CDCl[0175] ₃) δ: 5.13 (2H, s), 7.18 (1H, dd, J=6 Hz, 1 Hz), 7.23-7.43 (7H, m), 7.64-7.72 (5H, m), 7.85 (2H, d, J=8 Hz), 8.02 (1H, dd, J=6 Hz, 1 Hz), 8.75 (1H, dd, J=6 Hz, 1 Hz), 9.25 (1H, br-s), 10.53 (1H, br-s)
IR (ν, cm[0176] ⁻¹, KBr): 1698, 1658, 1536, 1478, 1442, 1358, 1324, 1310, 1174
EI-MS (m/z, %): 554 (M[0177] ⁺, 14), 368 (7), 211 (15), 173 (13)
Melting point: 220-221° C. [0178]

EXAMPLE 5

N-[2-(3-Benzyloxybenzamido)benzenesulfonyl]-4-nitrobenzamide

[0179]
A 300 mg (0.78 mmol) portion of 2-(3-benzyloxybenzamido)benzenesulfonamide produced in Reference Example 1, 290 mg (1.56 mmol) of 4-nitrobenzoyl chloride and 325 mg (2.34 mmol) of potassium carbonate were dissolved in water-dioxane 1:1 mixture (10 ml), and the solution was stirred for 18 hours. The solvent was evaporated, the resulting residue was extract with ethyl acetate, washed with water and saturated brine and dried over anhydrous sodium sulfate, and then the solvent was evaporated under a reduced pressure. The resulting residue was purified by a silica gel column chromatography to obtain 320 mg (yield: 77%) of the title compound. [0180]
NMR (CDCl[0181] ₃) δ: 5.14 (2H, s), 7.20 (1H, dd, J=6 Hz, 1 Hz), 7.22-7.46 (7H, m), 7.64 (1H, d, J=6 Hz), 7.65-7.70 (2H, m), 7.90 (2H, d, J=8 Hz), 8.04 (1H, d, J=6 Hz), 8.25 (2H, d, J=8 Hz), 8.74 (1H, d, J=6 Hz), 9.25 (1H, br-s), 10.53 (1H, br-s)
IR (ν, cm[0182] ⁻¹, KBr): 1696, 1662, 1608, 1474, 1442, 1344, 1320, 1276, 1250
EI-MS (m/z, %): 531 (M[0183] ⁺, 3), 303 (3), 212 (4), 211 (12)
Melting point: 233-234° C. [0184]

EXAMPLE 6

N-[2-(3-Benzyloxybenzamido)benzenesulfonyl]-4-methoxybenzamide

[0185]
A 300 mg (0.78 mmol) portion of 2-(3-benzyloxybenzamido)benzenesulfonamide produced in Reference Example 1, 267 mg (1.56 mmol) of 4-methoxybenzoyl chloride and 325 mg (2.34 mmol) of potassium carbonate were dissolved in water-dioxane 1:1 mixture (10 ml), and the solution was stirred for 18 hours. The solvent was evaporated, the resulting residue was extracted with ethyl acetate, washed with water and saturated brine and dried over anhydrous sodium sulfate, and then the solvent was evaporated under a reduced pressure. The resulting residue was purified by a silica gel column chromatography to obtain 282 mg (yield: 70%) of the title [0186]
NMR (CDCl[0187] ₃) δ: 3.38 (3H, s), 5.14 (2H, s), 6.90 (2H, d, J=8 Hz), 7.19 (1H, dd, J=7 Hz, 1 Hz), 7.22-7.46 (8H, m), 7.64-7.74 (3H, m), 7.77 (1H, m), 8.02 (1H, dd, J=7 Hz, 1 Hz), 8.73 (1H, br-s), 8.76 (1H, dd, J=7 Hz, 1 Hz), 10.63 (1H, br-s)
IR (ν, cm[0188] ⁻¹, KBr): 1702, 1688, 1606, 1582, 1536, 1516, 1490, 1472, 1444, 1414, 1344, 1310, 1270, 1248
EI-MS (m/z, %): 516 (M[0189] ⁺, 4), 424 (4), 303 (6), 302 (4), 212 (5), 211 (14)
Melting point: 189-190° C. [0190]

EXAMPLE 7

N-[2-(3-Benzyloxybenzamido)benzenesulfonyl]cyclohexamide

[0191]
In a stream of nitrogen and under ice-cooling, 196 mg (1.56 mmol) of potassium tert-butoxide was added to an anhydrous tetrahydrofuran (10 ml) solution containing 300 mg (0.78 mmol) of 2-(3-benzyloxybenzamido)benzenesulfonamide produced in Reference Example 1, and the mixture was stirred for 1 hour. This solution was mixed with 176 mg (1.19 mmol) of cyclohexanecarbonyl chloride and stirred at room temperature for 3 hours. After completion of the reaction, this was neutralized by adding an ammonium chloride aqueous solution and then the solvent was evaporated. The resulting residue was extracted with ethyl acetate, washed with water and saturated brine and dried over anhydrous sodium sulfate, and then the solvent was evaporated under a reduced pressure. The resulting residue was purified by a silica gel column chromatography to obtain 257 mg (yield: 67%) of the title compound. [0192]
NMR (CDCl[0193] ₃) δ: 1.03-1.39 (4H, m), 1.53-1.80 (6H, m), 2.04-2.18 (1H, m), 5.13 (2H, s), 7.17 (1H, dd, J=6 Hz, 1 Hz), 7.21-7.25 (1H, m), 7.31-7.43 (6H, m), 7.61-7.69 (2H, m), 7.70-7.72 (1H, m), 7.96 (1H, dd, J=6 Hz, 1 Hz), 8.49 (1H, s), 8.70 (1H, d, J=6 Hz), 10.46 (1H, s)
IR (ν, cm[0194] ⁻¹, KBr): 1710, 1662, 1582, 1530, 1488, 1476, 1448, 1382, 1342, 1304, 1274, 1246
EI-MS (m/z, %): 492 (M[0195] ⁺, 82), 382 (39), 302 (45), 211 (84), 91 (100)

EXAMPLE 8

N-[2-(3-Benzyloxybenzamido)benzenesulfonyl]-n-hexanamide

[0196]
In a stream of nitrogen and under ice-cooling, 210 mg (1.67 mmol) of potassium tert-butoxide was added to an anhydrous tetrahydrofuran (10 ml) solution containing 300 mg (0.78 mmol) of 2-(3-benzyloxybenzamido)benzenesulfonamide produced in Reference Example 1, and the mixture was stirred for 1 hour. This solution was mixed with 176 mg (1.19 mmol) of n-hexanoyl chloride and stirred at room temperature for 3 hours. After completion of the reaction, this was neutralized by adding an ammonium chloride aqueous solution and then the solvent was evaporated. The resulting residue was extracted with ethyl acetate, washed with water and saturated brine and dried over anhydrous sodium sulfate, and then the solvent was evaporated under a reduced pressure. The resulting residue was purified by a silica gel column chromatography to obtain 300 mg (yield: 86%) of the title compound. [0197]
NMR (CDCl[0198] ₃) δ: 0.80 (3H, t, J=7 Hz), 1.13-1.23 (4H, m), 1.47-1.58 (2H, m), 2.20 (2H, t, J=7 Hz), 5.13 (2H, s), 7.16 (1H, dd, J=6 Hz, 1 Hz), 7.21-7.25 (1H, m), 7.30-7.72 (6H, m), 7.61-7.72 (3H, m), 7.96 (1H, dd, J=6 Hz, IHz), 8.47 (1H, br-s), 8.70 (1H, dd, J=6 Hz, 1 Hz), 10.45 (1H, s)
IR (ν, cm[0199] ⁻¹, KBr): 1710, 1660, 1606, 1588, 1538, 1472, 1430, 1316, 1272
EI-MS (m/z, %): 480 (M[0200] ⁺, 57), 382 (27), 302 (31), 211 (71), 91 (100)
Melting point: 133-134° C. [0201]

EXAMPLE 9

N-[2-(3-Benzyloxybenzamido)benzenesulfonyl]decanamide

[0202]
In a stream of nitrogen and at 0° C., 117 mg (1.04 mmol) of potassium t-butoxide was added to an anhydrous tetrahydrofuran (10 ml) solution containing 200 mg (0.52 mmol) of 3-benzyloxy-N-(2-sulfamoylphenyl)benzamide produced in Reference Example 1, and the mixture was stirred for 1 hour. Next, this solution was mixed with 0.16 ml (0.78 mmol) of decanoyl chloride and stirred at room temperature for 3 hours. After completion of the reaction, this was neutralized by adding an ammonium chloride aqueous solution and then the solvent was evaporated. The resulting residue was extracted with ethyl acetate, washed with water and saturated brine in that order and dried over anhydrous sodium sulfate, and then the solvent was evaporated under a reduced pressure. The resulting residue was purified by a silica gel column chromatography to obtain 150 mg (yield: 50.0%) of the title compound. [0203]
NMR (CDCl[0204] ₃) δ: 0.80 (3H, t, J=7 Hz), 1.17-1.26 (12H, m), 1.50-1.59 (2H, m), 2.21 (2H, t, J=7 Hz), 5.14 (2H, s), 7.17 (1H, dd, J=8 Hz, 1 Hz), 7.24 (1H, ddd, J=8 Hz, 8 Hz, 1 Hz), 7.31-7.48 (8H, m), 7.61-7.72 (3H, m), 7.98 (1H, dd, J=8 Hz, 2 Hz), 8.30 (1H, br-s), 8.72 (1H, d, J=8 Hz), 10.43 (1H, s)
IR (ν, cm[0205] ⁻¹, KBr): 1704, 1662, 1606, 1588, 1540, 1472, 1342, 1166
FAB-MS (neg: m/z, %): 535 ([M—H]+100) [0206]
Melting point: 85-86° C. [0207]

EXAMPLE 10

N-[2-(3-Benzyloxybenzamido)benzenesulfonyl]pentafluorobenzamide

[0208]
A 300 mg (0.78 mmol) portion of 3-benzyloxy-N-(2-sulfamoylphenyl)benzamide produced in Reference Example 1, 271 mg (1.18 mmol) of pentafluorobenzoyl chloride and 374 mg (2.70 mmol) of potassium carbonate were dissolved in a mixed solvent (10 ml) of water and dioxane (1:1) and stirred at room temperature for 18 hours. After completion of the reaction, the solvent was evaporated under a reduced pressure. The resulting residue was extracted with ethyl acetate, washed with water and saturated brine in that order and dried over anhydrous sodium sulfate, and then the solvent was evaporated under a reduced pressure. The resulting residue was purified by a silica gel column chromatography to obtain 350 mg (yield: 77.0%) of the title compound. [0209]
NMR (CDCl[0210] ₃) δ: 5.14 (2H, s), 7.19 (1H, ddd, J=8 Hz, 2 Hz, 1 Hz), 7.31-7.48 (7H, m), 7.60 (1H, ddd, J=8 Hz, 2 Hz, 1 Hz), 7.66 (1H, dd, J=2 Hz, 1 Hz), 7.73 (1H, ddd, J=8 Hz, 8 Hz, 1 Hz), 8.06 (1H, dd, J=8 Hz, 1 Hz), 8.76 (1H, dd, J=1 Hz), 10.31 (1H, s)
EI-MS (m/z, %): 576 (m+, 20), 211 (14), 91 (100) [0211]
IR (ν, cm[0212] ⁻¹, KBr): 1704, 1654, 1582, 1536, 1506, 1440

EXAMPLE 11

N-[2-(3-Benzyloxybenzamido)benzenesulfonyl]-2,4-difluorobenzamide

[0213]
A 300 mg (0.78 mmol) portion of benzyloxy-N-(2-sulfamoylphenyl)benzamide, 273 mg (1.55 mmol) of 2,4-difluorobenzoyl chloride and 374 mg (2.70 mmol) of potassium carbonate were dissolved in a mixed solvent (10 ml) of water and dioxane (1:1) and stirred at room temperature for 18 hours. After completion of the reaction, the solvent was evaporated under a reduced pressure. The resulting residue was extracted with ethyl acetate, washed with water and saturated brine in that order and dried over anhydrous sodium sulfate, and then the solvent was evaporated under a reduced pressure. The resulting residue was purified by a silica gel column chromatography to obtain 350 mg (yield: 86.0%) of the title compound. [0214]
NMR (CDCl[0215] ₃) δ: 5.15 (2H, s), 6.92 (1H, ddd, J=8 Hz, 8 Hz, 2 Hz), 7.05 (1H, ddd, J=8 Hz, 8 Hz, 2 Hz), 7.17 (1H, ddd, J=8 Hz, 8 Hz, 1 Hz), 7.22 (1H, ddd, J=8 Hz, 2 Hz, 1 Hz), 7.30-7.50 (7H, m), 7.58 (1H, dd, J=8 Hz, 1 Hz), 7.70 (1H, dd, J=2 Hz, 1 Hz), 7.73-7.78 (1H, m), 7.83 (1H, dd, J=8 Hz, 2 Hz), 8.41 (1H, dd, J=8 Hz, 1 Hz), 11.36 (1H, s)
IR (ν, cm[0216] ⁻¹, KBr): 1678, 1608, 1580, 1546, 1498
FAB-MS (neg: m/z, %): 521 ([M—H]+100) [0217]
Melting point: 208-209° C. [0218]

REFERENCE EXAMPLE 2

3-(4-t-Butylbenzyloxy)-N-(2-sulfamoylphenyl)benzamide

[0219]
A benzene (30 ml) solution containing 4.00 g (14.0 mmol) of 3-(4-t-butylbenzyloxy)benzoic acid and 3 ml of thionyl chloride was heated under reflux for 2 hours and then the solvent was evaporated under a reduced pressure. The resulting residue was dissolved in methylene chloride (30 ml), this solution was added dropwise under ice-cooling to a pyridine (50 ml) solution containing 2.42 g (14.0 mmol) of 2-aminobenzenesulfonamide, the mixture was stirred at room temperature for 18 hours and then methylene chloride was evaporated under a reduced pressure. The resulting residue was dissolved in ethyl acetate, washed with a 1 N hydrochloric acid aqueous solution, water and saturated brine in that order and dried over anhydrous sodium sulfate, and then the solvent was evaporated under a reduced pressure. The thus obtained crude crystals were recrystallized from an ether-hexane mixed solvent to obtain 4.2 g (yield: 68.0%) of the title compound. [0220]
NMR (CDCl[0221] ₃) δ: 1.38 (9H, s), 4.92 (2H, s), 5.09 (2H, s), 7.16 (1H, ddd, J=8 Hz, 2 Hz, 1 Hz), 7.23 (1H, ddd, J=8 Hz, 8 Hz, 2 Hz), 7.36-7.44 (5H, m), 7.49 (1H, dd, J=8 Hz, 1 Hz), 7.56-7.63 (2H, m), 7.94 (1H, dd, J=8 Hz, 2 Hz), 8.53 (1H, dd, J=8 Hz, 1 Hz), 10.04 (1H, s)
EI-MS (m/z, %): 438 (m+, 37), 147 (100), 132 (84), 117 (65) [0222]
IR (ν, cm[0223] ⁻¹, KBr): 1674, 1658, 1586, 1538, 1446, 1332, 1168
Melting point: 117-118° C. [0224]

EXAMPLE 12

N-[2-[3-(4-t-Butylbenzyloxy)benzamido]benzenesulfonyl]pivalamide

[0225]
In a stream of nitrogen and at 0° C., 0.09 ml (0.75 mmol) of pivaloyl chloride was added to an anhydrous tetrahydrofuran (10 ml) solution containing 300 mg (0.68 mmol) of 3-(4-t-butylbenzyloxy)-N-(2-sulfamoylphenyl)benzamide produced in Reference Example 2 and 167 mg (1.36 mmol) of 4-dimethylaminopyridine, the mixture was stirred at room temperature for 1 hour and then the solvent was evaporated under a reduced pressure. The resulting residue was dissolved in ethyl acetate, washed with water, a potassium hydrgensulfate aqueous solution and saturated brine in that order and dried over anhydrous sodium sulfate, and then the solvent was evaporated under a reduced pressure. The resulting residue was purified by a silica gel column chromatography to obtain 284 mg (yield: 80.0%) of the title compound. [0226]
NMR (CDCl[0227] ₃) δ: 1.14 (9H, s), 1.33 (9H, s), 5.10 (2H, s), 7.18 (1H, dd, J=8 Hz, 2 Hz), 7.25 (1H, ddd, J=8 Hz, 8 Hz, 2 Hz), 7.38-7.45 (10H, m), 7.63 (1H, dd, J=8 Hz, 2 Hz), 7.67 (1H, ddd, J=8 Hz, 8 Hz, 2 Hz), 7.72-7.75 (1H, m), 7.97 (1H, dd, J=8 Hz, 2 Hz), 8.27 (1H, br-s), 8.72 (1H, dd, J=8 Hz, 2 Hz), 10.41 (1H, s)
IR (ν, cm[0228] ⁻¹, KBr): 1702, 1660, 1580, 1538, 1478, 1448, 1342, 1312, 1292
EI-MS (m/z, %): 522 (m+, 72), 147 (100) [0229]
Melting point: 193-194° C. [0230]

EXAMPLE 13

N-[2-[3-(4-t-Butylbenzyloxy)benzamido]benzenesulfonyl]cinnamamide

[0231]
In a stream of nitrogen and at 0° C., 126 mg (0.75 mmol) of cinnamoyl chloride was added to an anhydrous tetrahydrofuran (10 ml) solution containing 300 mg (0.68 mmol) of 3-(4-t-butylbenzyloxy)-N-(2-sulfamoylphenyl)benzamide produced in Reference Example 2 and 167 mg (1.36 mmol) of 4-dimethylaminopyridine, the mixture was stirred at room temperature for 1 hour and then the solvent was evaporated under a reduced pressure. The resulting residue was dissolved in ethyl acetate, washed with water, a potassium hydrgensulfate aqueous solution and saturated brine in that order and dried over anhydrous sodium sulfate, and then the solvent was evaporated under a reduced pressure. The resulting crude crystals were washed with methanol to obtain 370 mg (yield: 95.0%) of the title compound. [0232]
NMR (CDCl[0233] ₃) δ: 1.31 (9H, s), 5.11 (2H, s), 6.31 (1H, d, J=16 Hz), 7.17 (1H, ddd, J=8 Hz, 2 Hz, 1 Hz), 7.24 (1H, ddd, J=8 Hz, 8 Hz, 1 Hz), 7.31-7.44 (10H, m), 7.64-7.70 (3H, m), 7.77-7.78 (1H, m), 8.01 (1H, dd, J=8 Hz, 2 Hz), 8.74 (1H, dd, J=8 Hz, 1 Hz), 10.60 (1H, s)
IR (ν, cm[0234] ⁻¹, KBr): 1688, 1668, 1630, 1582, 1534, 1476, 1442, 1334, 1310, 1272
EI-MS (m/z, %): 568 (m+, 3), 437 (3), 147 (100) [0235]
Melting point: 110-111° C. [0236]

EXAMPLE 14

N-[2-(3-Benzyloxybenzamido)benzenesulfonyl]oleinamide

[0237]
In a stream of nitrogen and at 0° C., 787 mg (2.62 mmol) of oleyl chloride was added to an anhydrous tetrahydrofuran (10 ml) solution containing 500 mg (1.30 mmol) of 3-benzyloxy-(2-sulfamoylphenyl)benzamide produced in Reference Example 1 and 480 mg (3.93 mmol) of 4-dimethylaminopyridine, the mixture was stirred at room temperature for 1 hour and then the solvent was evaporated under a reduced pressure. The resulting residue was dissolved in ethyl acetate, washed with water, a potassium hydrgensulfate aqueous solution and saturated brine in that order and dried over anhydrous sodium sulfate, and then the solvent was evaporated under a reduced pressure. The resulting residue was purified by a silica gel column chromatography to obtain 625 mg (yield: 74.0%) of the title compound. [0238]
NMR (CDCl[0239] ₃) δ: 0.87 (3H, t, J=7 Hz), 1.15-1.38 (19H, m), 1.45-1.62 (4H, m), 1.85-2.01 (3H, m), 2.20 (2H, t, J=7 Hz), 5.14 (2H, s), 5.30-5.42 (2H, m), 7.17 (1H, ddd, J=8 Hz, 2 Hz, 1 Hz), 7.50 (1H, ddd, J=8 Hz, 8 Hz, 1 Hz), 7.31-7.48 (6H, m), 7.61-7.72 (3H, m), 7.78 (1H, dd, J=8 Hz, 2 Hz), 8.31 (1H, br-s), 8.72 (1H, dd, J=8 Hz, 1 Hz), 10.43 (1H, s)
IR (ν, cm[0240] ⁻¹, KBr): 1708, 1660, 1606, 1588, 1542, 1472, 1448, 1338
EI-MS (m/z, %): 646 (m+, 14), 383 (57), 302 (12), 211 (97), 91 (100) [0241]
Melting point: 82-83° C. [0242]

EXAMPLE 15

N-[2-(3-Benzyloxybenzamido)benzenesulfonyl]linolamide

[0243]
A benzene (30 ml) solution containing 440 mg (1.57 mmol) of linoleic acid and 3 ml of thionyl chloride was heated under reflux for 2 hours, and then the solvent was evaporated under a reduced pressure. The thus obtained residue was dissolved in anhydrous tetrahydrofuran (10 ml), this solution was added dropwise under ice-cooling to an anhydrous tetrahydrofuran (10 ml) solution containing 500 mg (1.30 mmol) of 3-benzyloxy-N-(2-sulfamoylphenyl)benzamide produced in Reference Example 1 and 352 mg (2.88 mmol) of 4-dimethylaminopyridine, and the mixture was stirred at roam temperature for 1 hour. After evaporation of the solvent under a reduced pressure, the resulting residue was dissolved in ethyl acetate, washed with water, a potassium hydrgensulfate aqueous solution and saturated brine in that order and dried over anhydrous sodium sulfate, and then the solvent was evaporated under a reduced pressure. The resulting residue was purified by a silica gel column chromatography to obtain 625 mg (yield: 74.0%) of the title compound. [0244]
NMR (CDCl[0245] ₃) δ: 0.88 (3H, t, J=7 Hz), 1.10-1.38 (12H, m), 1.40-1.70 (4H, m), 1.93-2.10 (4H, m), 2.20 (2H, t, J=8 Hz), 2.74 (2H, dd, J=6 Hz, 6 Hz), 5.13 (2H, s), 5.25-5.42 (4H, m), 7.16 (1H, dd, J=8 Hz, 2 Hz), 7.24 (1H, ddd, J=8 Hz, 8 Hz, 1 Hz), 7.30-7.50 (6H, m), 7.60-7.71 (3H, m), 7.96 (1H, dd, J=8 Hz, 2 Hz), 8.54 (1H, br-s), 8.70 (1H, dd, J=8 Hz, 1 Hz), 10.45 (1H, s)
IR (ν, cm[0246] ⁻¹, KBr): 1714, 1660, 1606, 1588, 1540, 1472, 1448, 1338
FAB-MS (neg: m/z, %): 643 ([M—H]+100) [0247]

REFERENCE EXAMPLE 3

3-Benzyloxy-4-nitro-N-(2-sulfamoylphenyl)benzamide

[0248]
A benzene (30 ml) solution containing 2.00 g (7.30 mmol) of 3-benzyloxy-4-nitrobenzoic acid and 3 ml of thionyl chloride was heated under reflux for 2 hours and then the solvent was evaporated under a reduced pressure. The resulting residue was dissolved in methylene chloride (30 ml), this solution was added dropwise under ice-cooling to a pyridine (50 ml) solution containing 1.38 g (8.00 mmol) of 2-aminobenzenesulfonamide, the mixture was stirred at room temperature for 18 hours and then methylene chloride was evaporated under a reduced pressure. The resulting residue was dissolved in ethyl acetate, washed with a 1 N hydrochloric acid aqueous solution, water and saturated brine in that order and dried over anhydrous sodium sulfate, and then the solvent was evaporated under a reduced pressure. The thus obtained crude crystals were washed with methanol to obtain 2.50 g (yield: 80.0%) of the title compound. [0249]
NMR (DMSO-d[0250] ₆) δ: 5.41 (2H, s), 7.34-7.52 (6H, m), 7.61 (1H, dd, J=8 Hz, 2 Hz), 7.69 (1H, ddd, J=8 Hz, 8 Hz, 2 Hz), 7.91-7.96 (2H, m), 8.11 (1H, d, J=8 Hz), 8.33 (1H, d, J=8 Hz), 10.41 (1H, s)

EXAMPLE 16

N-[2-(3-Benzyloxy-4-nitrobenzamido)benzenesulfonyl]decanamide

[0251]
In a stream of nitrogen and at 0° C., 0.24 ml (1.16 mmol) of decanoyl chloride was added to an anhydrous tetrahydrofuran (10 ml) solution containing 435 mg (1.02 ml) of 3-benzyloxy-4-nitro-N-(2-sulfamoylphenyl)benzamide produced in Reference Example 3 and 274 mg (2.23 mmol) of 4-dimethylaminopyridine, the mixture was stirred at room temperature for 1 hour and then the solvent was evaporated under a reduced pressure. The resulting residue was dissolved in ethyl acetate, washed with water, a potassium hydrgensulfate aqueous solution and saturated brine in that order and dried over anhydrous sodium sulfate, and then the solvent was evaporated under a reduced pressure. The resulting residue was purified by a silica gel column chromatography to obtain 490 mg (yield: 83.0%) of the title compound. [0252]
NMR (CDCl[0253] ₃) δ: 0.86 (3H, t, J=7 Hz), 1.10-1.30 (12H, m), 1.48-1.65 (2H, m), 2.25 (2H, t, J=7 Hz), 5.32 (2H, s), 7.24-7.43 (4H, m), 7.47-7.51 (2H, m), 7.68-7.74 (2H, m), 7.92-7.99 (3H, m), 8.71 (1H, dd, J=8 Hz, 2 Hz), 10.64 (1H, s)
IR (ν, cm[0254] ⁻¹, KBr): 1722, 1668, 1614, 1588, 1538, 1472, 1444, 1404, 1342, 1322, 1292
EI-MS (m/z, %): 581 (m+, 2), 321 (11), 211 (2), 91 (100) [0255]
Melting point: 129-130° C. [0256]

REFERENCE EXAMPLE 4

3-(4-Chlorobenzyloxy)-N-(2-sulfamoylphenyl)benzamide

[0257]
A benzene (30 ml) solution containing 4.00 g (15.2 mmol) of 3-(4-chlorobenzyloxy)benzoic acid and 3 ml of thionyl chloride was heated under reflux for 2 hours and then the solvent was evaporated under a reduced pressure. The resulting residue was dissolved in methylene chloride (30 ml), this solution was added dropwise under ice-cooling to a pyridine (50 ml) solution containing 2.75 g (16.0 mmol) of 2-aminobenzenesulfonamide, the mixture was stirred at room temperature for 18 hours and then methylene chloride was evaporated under a reduced pressure. The resulting residue was dissolved in ethyl acetate, washed with a 1 N hydrochloric acid aqueous solution, water and saturated brine in that order and dried over anhydrous sodium sulfate, and then the solvent was evaporated under a reduced pressure. The thus obtained crude crystals were washed with methanol to obtain 4.70 g (yield: 74.0%) of the title compound. [0258]
NMR (DMSO-d[0259] ₆) δ: 5.20 (2H, s), 7.27-7.31 (1H, m), 7.34 (1H, ddd, J=8 Hz, 8 Hz, 2 Hz), 7.45-7.56 (7H, m), 7.65 (1H, ddd, J=8 Hz, 8 Hz, 2 Hz), 7.77 (2H, s), 7.92 (1H, dd, J=8 Hz, 2 Hz), 8.47 (1H, dd, J=8 Hz, 1 Hz), 10.38 (1H, s)
EI-MS (m/z, %): 418 (m+2, 6), 416 (m+, 17) [0260]
IR (ν, cm[0261] ⁻¹, KBr): 1672, 1586, 1542, 1446, 1154
Melting point: 174-175° C. [0262]

EXAMPLE 17

N-[2-[3-(4-Chlorobenzyloxy)benzamido]benzenesulfonyl]acetamide

[0263]
In a stream of nitrogen and at 0° C., 0.12 ml (1.30 mmol) of acetic anhydride was added to an anhydrous tetrahydrofuran (10 ml) solution containing 500 mg (1.20 mmol) of 3-(4-chlorobenzyloxy)-N-(2-sulfamoylphenyl)benzamide produced in Reference Example 4 and 293 mg (2.40 mmol) of 4-dimethylaminopyridine, the mixture was stirred at room temperature for 1 hour and then the solvent was evaporated under a reduced pressure. The resulting residue was dissolved in ethyl acetate, washed with water, a potassium hydrgensulfate aqueous solution and saturated brine in that order and dried over anhydrous sodium sulfate, and then the solvent was evaporated under a reduced pressure. The resulting residue was recrystallized from an ethyl acetate-diethyl-ether mixed solvent to obtain 290 mg (yield: 52.7%) of the title compound. [0264]
NMR (CDCl[0265] ₃) δ: 2.06 (3H, s), 5.11 (2H, s), 7.16 (1H, ddd, J=8 Hz, 2 Hz, 1 Hz), 7.23-7.29 (1H, m), 7.34-7.44 (5H, m), 7.61-7.72 (3H, m), 7.98 (1H, dd, J=8 Hz, 1 Hz), 8.18 (1H, br-s), 8.73 (1H, dd, J=8 Hz, 1 Hz), 10.41 (1H, br-s)
IR (ν, cm[0266] ⁻¹, KBr): 3768, 3108, 2872, 1716, 1666, 1580, 1538, 1478, 1448
EI-MS (m/z, %): 460 (9), 458 (23), 336 (5), 245 (11), 183 (6), 127 (53), 125 (100), 92 (10) [0267]
Melting point: 176-179° C. [0268]

EXAMPLE 18

N-[2-[3-(4-Chlorobenzyloxy)benzamido]benzenesulfonyl]hexanamide

[0269]
In a stream of nitrogen and at 0° C., 0.18 ml (1.30 mmol) of hexanoyl chloride was added to an anhydrous tetrahydrofuran (10 ml) solution containing 500 mg (1.2 mmol) of 3-(4-chlorobenzyloxy)-N-(2-sulfamoylphenyl)benzamide produced in Reference Example 4 and 293 mg (2.40 mmol) of 4-dimethylaminopyridine, the mixture was stirred at room temperature for 1 hour and then the solvent was evaporated under a reduced pressure. The resulting residue was dissolved in ethyl acetate, washed with water, a potassium hydrgensulfate aqueous solution and saturated brine in that order and dried over anhydrous sodium sulfate, and then the solvent was evaporated under a reduced pressure. The resulting residue was purified by a silica gel column chromatography to obtain 600 mg (yield: 97%) of the title compound. [0270]
NMR (CDCl[0271] ₃) δ: 0.81 (3H, t, J=7 Hz), 1.13-1.28 (4H, m), 1.48-1.60 (2H, m), 2.22 (2H, t, J=7 Hz), 5.11 (2H, s), 7.15 (1H, ddd, J=8 Hz, 2 Hz, 1 Hz), 7.23-7.28 (1H, m), 7.34-7.43 (5H, m), 7.62-7.70 (1H, m), 7.97 (1H, dd, J=8 Hz, 2 Hz), 8.21 (1H, br-s), 8.73 (1H, dd, J=8 Hz, 1 Hz), 10.45 (1H, br-s)
IR (ν, cm[0272] ⁻¹, KBr): 3392, 3080, 2952, 2932, 2868, 1720, 1658, 1580, 1536, 1486, 1474, 1448, 1412
EI-MS (m/z, %): 526 (4), 514 (8), 336 (4), 245 (9), 183 (4), 127 (31), 125 (100) [0273]
Melting point: 148-149° C. [0274]

EXAMPLE 19

N-[2-[3-(4-Chlorobenzyloxy)benzamido]benzenesulfonyl]decanamide

[0275]
In a stream of nitrogen and at 0° C., 0.27 ml (1.30 mmol) of decanoyl chloride was added to an anhydrous tetrahydrofuran (10 ml) solution containing 500 mg (1.20 mmol) of 3-(4-chlorobenzyloxy)-N-(2-sulfamoylphenyl)benzamide produced in Reference Example 4 and 293 mg (2.40 mmol) of 4-dimethylaminopyridine, the mixture was stirred at roam temperature for 1 hour and then the solvent was evaporated under a reduced pressure. The resulting residue was dissolved in ethyl acetate, washed with water, a potassium hydrgensulfate aqueous solution and saturated brine in that order and dried over anhydrous sodium sulfate, and then the solvent was evaporated under a reduced pressure. The resulting residue was purified by a silica gel column chromatography to obtain 640 mg (yield: 93.0%) of the title [0276]
NMR (CDCl[0277] ₃) δ: 0.86 (3H, t, J=7 Hz), 1.15-1.30 (12H, m), 1.48-1.59 (2H, m), 2.22 (2H, t, J=7 Hz), 5.11 (2H, s), 7.15 (1H, ddd, J=8 Hz, 2 Hz, 1 Hz), 7.23-7.28 (1H, m), 7.34-7.44 (5H, m), 7.62-7.70 (3H, m), 7.97 (1H, dd, J=8 Hz, 1 Hz), 8.18 (1H, br-s), 8.73 (1H, dd, J=8 Hz, 1 Hz), 10.45 (1H, br-s)
IR (ν, cm[0278] ⁻¹, KBr): 3368, 3032, 2920, 2852, 1702, 1662, 1604, 1586, 1542, 1494, 1472, 1448, 1438
EI-MS (m/z, %): 572 (2), 570 (4), 336 (4), 245 (10), 183 (3), 127 (32), 125 (100) [0279]
Melting point: 159-161° C. [0280]

REFERENCE EXAMPLE 5

3-(4-Nitrobenzyloxy)-N-(2-sulfamoylphenyl)benzamide

[0281]
A benzene (20 ml) solution containing 1.40 g (5.1 mmol) of 3-(4-nitrobenzyloxy)benzoic acid and 2 ml of thionyl chloride was heated under reflux for 2 hours and then the solvent was evaporated under a reduced pressure. The resulting residue was dissolved in methylene chloride (20 ml), this solution was added dropwise under ice-cooling to a pyridine (30 ml) solution containing 0.97 g (5.6 mmol) of 2-aminobenzenesulfonamide, the mixture was stirred at room temperature for 18 hours and then methylene chloride was evaporated under a reduced pressure. The resulting residue was dissolved in ethyl acetate, washed with a 1 N hydrochloric acid aqueous solution, water and saturated brine in that order and dried over anhydrous sodium sulfate, and then the solvent was evaporated under a reduced pressure. The thus obtained crude crystals were washed with methanol to obtain 1.9 g (yield: 87.0%) of the title compound. [0282]
NMR (DMSO-d[0283] ₆) δ: 5.39 (2H, s), 7.30-7.38 (2H, m), 7.50-7.58 (3H, m), 7.65 (1H, ddd, J=8 Hz, 8 Hz, 2 Hz), 7.75-7.80 (4H, m), 7.91 (1H, dd, J=8 Hz, 2 Hz), 8.25-8.30 (2H, m), 8.46 (1H, dd, J=8, 1 Hz), 10.38 (1H, s)
EI-MS (m/z, %): 427 (m+, 23), 347 (82), 256 (100), 121 (50) [0284]
IR (ν, cm[0285] ⁻¹, KBr): 1658, 1590, 1530, 1446, 1344, 1152, 1046
Melting point: 177-178° C. [0286]

EXAMPLE 20

N-[2-[3-(4-Nitrobenzyloxy)benzamido]benzenesulfonyl]acetamide

[0287]
In a stream of nitrogen and at 0° C., 0.07 ml (0.80 mmol) of acetic anhydride was added to an anhydrous tetrahydrofuran (10 ml) solution containing 300 mg (0.70 mmol) of 3-(4-nitrobenzyloxy)-N-(2-sulfamoylphenyl)benzamide produced in Reference Example 5 and 171 mg (1.40 mmol) of 4-dimethylaminopyridine, the mixture was stirred at roam temperature for 1 hour and then the solvent was evaporated under a reduced pressure. The resulting residue was dissolved in ethyl acetate, washed with water, a potassium hydrgensulfate aqueous solution and saturated brine in that order and dried over anhydrous sodium sulfate, and then the solvent was evaporated under a reduced pressure. The resulting residue was purified by a silica gel column chromatography to obtain 290 mg (yield: 89.8%) of the title compound. [0288]
NMR (CDCl[0289] ₃) δ: 2.05 (3H, s), 5.25 (2H, s), 7.15-7.19 (1H, m), 7.23-7.29 (1H, m), 7.40-7.45 (1H, m), 7.60-7.71 (5H, m), 7.96 (1H, dd, J=8 Hz, 1 Hz), 8.22-8.27 (2H, m), 8.47 (1H, br-s), 8.72 (1H, dd, J=8 Hz, 1H, z), 10.45 (1H, br-s)
IR (ν, cm[0290] ⁻¹, KBr): 3384, 3124, 2856, 1714, 1660, 1580, 1532, 1520, 1490, 1476, 1446
EI-MS (m/z, %): 469 (9), 347 (15), 256 (27), 182 (8), 154 (4), 125 (100), 121 (27) [0291]
Melting point: 189-192° C. [0292]

EXAMPLE 21

N-[2-[3-(4-Nitrobenzyloxy)benzamido]benzenesulfonyl]hexanamide

[0293]
In a stream of nitrogen and at 0° C., 0.11 ml (0.80 mmol) of hexanoyl chloride was added to an anhydrous tetrahydrofuran (10 ml) solution containing 300 mg (0.70 mmol) of 3-(4-nitrobenzyloxy)-N-(2-sulfamoylphenyl)benzamide produced in Reference Example 5 and 171 mg (1.40 mmol) of 4-dimethylaminopyridine, the mixture was stirred at room temperature for 1 hour and then the solvent was evaporated under a reduced pressure. The resulting residue was dissolved in ethyl acetate, washed with water, a potassium hydrgensulfate aqueous solution and saturated brine in that order and dried over anhydrous sodium sulfate, and then the solvent was evaporated under a reduced pressure. The resulting residue was purified by a silica gel column chromatography to obtain 320 mg (yield: 86.8%) of the title compound. [0294]
NMR (CDCl[0295] ₃) δ: 0.81 (3H, t, J=7 Hz), 1.13-1.28 (4H, m), 1.49-1.59 (2H, m), 2.23 (2H, t, J=7 Hz), 5.25 (2H, s), 7.15-7.20 (1H, m), 7.23-7.29 (1H, m), 7.61-7.71 (5H, m), 7.97 (1H, dd, J=8 Hz, 1 Hz), 8.22-8.29 (3H, m), 8.73 (1H, dd, J=8 Hz, 1 Hz), 10.48 (1H, br-s)
IR (ν, cm[0296] ⁻¹, KBr): 3372, 3064, 2956, 2932, 2860, 1714, 1664, 1604, 1586, 1526, 1490, 1472, 1446
EI-MS (m/z, %): 525 (32), 411 (6), 347 (86), 256 (100), 182 (20), 121 (50), 92 (17) [0297]
Melting point: 138-141° C. [0298]

EXAMPLE 22

N-[2-[3-(4-Nitrobenzyloxy)benzamido]benzenesulfonyl]decananide

[0299]
In a stream of nitrogen and at 0° C., 0.16 ml (0.80 mmol) of decanoyl chloride was added to an anhydrous tetrahydrofuran (10 ml) solution containing 300 mg (0.70 mmol) of 3-(4-nitrobenzyloxy)-N-(2-sulfamoylphenyl)benzamide produced in Reference Example 5 and 171 mg (1.40 mmol) of 4-dimethylaminopyridine, the mixture was stirred at room temperature for 1 hour and then the solvent was evaporated under a reduced pressure. The resulting residue was dissolved in ethyl acetate, washed with water, a potassium hydrgensulfate aqueous solution and saturated brine in that order and dried over anhydrous sodium sulfate, and then the solvent was evaporated under a reduced pressure. The resulting residue was purified by a silica gel column chromatography to obtain 400 mg (yield: 97.9%) of the title compound. [0300]
NMR (CDCl[0301] ₃) δ: 0.86 (3H, t, J=7 Hz), 1.15-L 1.30 (12H, m), 1.48-1.59 (2H, m), 2.23 (2H, t, J=7 Hz), 5.25 (2H, s), 7.15-7.20 (1H, m), 7.23-7.29 (1H, m), 7.40-7.46 (1H, m), 7.61-7.71 (5H, m), 7.96 (1H, dd, J=8 Hz, 1 Hz), 8.22 (1H, br-s), 8.23-8.29 (2H, m), 8.73 (1H, dd, J=8 Hz, 1 Hz), 10.48 (1H, br-s)
IR (ν, cm[0302] ⁻¹, KBr): 3376, 3068, 2924, 2852, 1704, 1668, 1606, 1588, 1256, 1490, 1472, 1446
EI-MS (m/z, %): 581 (20), 411 (8), 347 (87), 256 (100), 182 (19), 136 (22) [0303]
Melting point: 145-148° C. [0304]

REFERENCE EXAMPLE 6

3-(4-Methoxybenzyloxy)-N-(2-sulfamoylphenyl)benzamide

[0305]
A benzene (30 ml) solution containing 4.00 g (15.5 mmol) of 3-(4-methoxybenzyloxy)benzoic acid and 3 ml of thionyl chloride was heated under reflux for 2 hours and then the solvent was evaporated under a reduced pressure. The resulting residue was dissolved in methylene chloride (30 ml), this solution was added dropwise under ice-cooling to a pyridine (50 ml) solution containing 2.93 g (17.0 mmol) of 2-aminobenzenesulfonamide, the mixture was stirred at room temperature for 18 hours and then methylene chloride was evaporated under a reduced pressure. The resulting residue was dissolved in ethyl acetate, washed with a 1 N hydrochloric acid aqueous solution, water and saturated brine in that order and dried over anhydrous sodium sulfate, and then the solvent was evaporated under a reduced pressure. The thus obtained residue was purified by a silica gel chromatography to obtain 1.5 g (yield: 31.0%) of the title compound. [0306]
NMR (DMSO-d[0307] ₆) δ: 3.76 (3H, s), 5.11 (2H, s), 6.96 (2H, d, J=8 Hz), 7.25-7.30 (1H, m), 7.33 (1H, ddd, J=8 Hz, 8 Hz, 1 Hz), 7.73 (2H, br-s), 7.90 (1H, dd, J=8 Hz, 1 Hz), 8.48 (1H, d, J=8 Hz), 10.38 (1H, br-s)
EI-MS (m/z, %): 412 (m+, 6), 370 (6), 292 (3), 279 (10), 121 (100) [0308]
IR (ν, cm[0309] ⁻¹, KBr): 1676, 1612, 1586, 1538, 1518, 1152
Melting point: 164-165° C. [0310]

EXAMPLE 23

N-[2-[3-(4-methoxybenzyloxy)benzamido]benzenesulfonyl]acetamide

[0311]
In a stream of nitrogen and at 0° C., 0.1 ml (1.10 mmol) of acetic anhydride was added to an anhydrous tetrahydrofuran (10 ml) solution containing 400 mg (1.00 mmol) of 3-(4-methoxybenzyloxy)-N-(2-sulfamoylphenyl)benzamide produced in Reference Example 6 and 237 mg (1.90 mmol) of 4-dimethylaminopyridine, the mixture was stirred at room temperature for 1 hour and then the solvent was evaporated under a reduced pressure. The resulting residue was dissolved in ethyl acetate, washed with water, a potassium hydrgensulfate aqueous solution and saturated brine in that order and dried over anhydrous sodium sulfate, and then the solvent was evaporated under a reduced pressure. The resulting residue was purified by a silica gel column chromatography to obtain 430 mg (yield: 97.6%) of the title compound. [0312]
NMR (CDCl[0313] ₃) δ: 2.04 (3H, s), 3.82 (3H, s), 5.07 (2H, s), 6.90-6.96 (2H, m), 7.16 (1H, ddd, J=8 Hz, 2 Hz, 1 Hz), 7.22-7.29 (1H, m), 7.35-7.43 (3H, m), 7.58-7.63 (1H, m), 7.65-7.71 (2H, m), 7.98 (1H, dd, J=8 Hz, 1 Hz), 8.27 (1H, br-s), 8.73 (1H, dd, J=8 Hz, 1 Hz), 10.34 (1H, br-s)
IR (ν, cm[0314] ⁻¹, KBr): 3384, 3084, 2872, 1718, 1658, 1612, 1580, 1538, 1518, 1476, 1448
EI-MS (m/z, %): 454 (7), 334 (37), 240 (9), 121 (100) [0315]
Melting point: 114-117° C. [0316]

EXAMPLE 24

N-[2-[3-(4-Methoxybenzyloxy)benzamido]benzenesulfonyl]hexanamide

[0317]
In a stream of nitrogen and at 0° C., 0.15 ml (1.10 mmol) of hexanoyl chloride was added to an anhydrous tetrahydrofuran (10 ml) solution containing 400 mg (1.00 mmol) of 3-(4-methoxybenzyloxy)-N-(2-sulfamoylphenyl)benzamide produced in Reference Example 6 and 237 mg (1.90 mmol) of 4-dimethylaminopyridine, the mixture was stirred at room temperature for 1 hour and then the solvent was evaporated under a reduced pressure. The resulting residue was dissolved in ethyl acetate, washed with water, a potassium hydrgensulfate aqueous solution and saturated brine in that order and dried over anhydrous sodium sulfate, and then the solvent was evaporated under a reduced pressure. The resulting residue was purified by a silica gel column chromatography to obtain 490 mg (yield: 98.8%) of the title compound. [0318]
NMR (CDCl[0319] ₃) δ: 0.81 (3H, t, J=7 Hz), 1.13-1.27 (4H, m), 1.48-1.59 (2H, m), 2.21 (2H, t, J=7 Hz), 3.82 (3H, s), 5.07 (2H, s), 6.90-6.96 (2H, m), 7.16 (1H, ddd, J=8 Hz, 2 Hz, 1 Hz), 7.22-7.29 (1H, m), 7.36-7.44 (3H, m), 7.60-7.72 (3H, m), 7.99 (1H, dd, J=8 Hz, 1 Hz), 8.13 (1H, br-s), 8.73 (1H, dd, J=8 Hz, 1 Hz), 10.42 (1H, br-s)
IR (ν, cm[0320] ⁻¹, KBr): 3392, 3072, 2956, 2932, 2872, 1716, 1658, 1614, 1580, 1538, 1520, 1450, 1412
EI-MS (m/z, %): 510 (2), 390 (2), 178 (6), 154 (2), 121 (100) [0321]
Melting point: 154-157° C. [0322]

EXAMPLE 25

N-[2-[3-(4-methoxybenzyloxy)benzamido]benzenesulfonyl]decanamide

[0323]
In a stream of nitrogen and at 0° C., 0.22 ml (1.10 mmol) of decanoyl chloride was added to an anhydrous tetrahydrofuran (10 ml) solution containing 400 mg (1.00 mmol) of 3-(4-methoxybenzyloxy)-N-(2-sulfamoylphenyl)benzamide produced in Reference Example 6 and 237 mg (1.90 mmol) of 4-dimethylaminopyridine, the mixture was stirred at room temperature for 1 hour and then the solvent was evaporated under a reduced pressure. The resulting residue was dissolved in ethyl acetate, washed with water, a potassium hydrgensulfate aqueous solution and saturated brine in that order and dried over anhydrous sodium sulfate, and then the solvent was evaporated under a reduced pressure. The resulting residue was purified by a silica gel column chromatography to obtain 520 mg (yield: 94.6%) of the title compound. [0324]
NMR (CDCl[0325] ₃) δ: 0.87 (3H, t, J=7 Hz), 1.15-1.32 (12H, m), 1.49-1.60 (2H, m), 2.22 (2H, t, J=7 Hz), 3.83 (3H, s), 5.08 (2H, s), 6.91-6.96 (2H, m), 7.17 (1H, ddd, J=8 Hz, 2 Hz, 1 Hz), 7.23-7.30 (1H, m), 7.36-7.44 (3H, m), 7.61-7.73 (3H, m), 8.00 (1H, dd, J=8 Hz, 1 Hz), 8.05 (1H, br-s), 8.74 (1H, dd, J=8 Hz, 1 Hz), 10.43 (1H, br-s)
IR (ν, cm[0326] ⁻¹, KBr): 3364, 3036, 2920, 2852, 1704, 1660, 1602, 1586, 1540, 1518, 1490, 1472, 1448, 1440
EI-MS (m/z, %): 566 (3), 275 (9), 211 (8), 121 (100) [0327]
Melting point: 148-149° C. [0328]

REFERENCE EXAMPLE 7

3-Cyclohexylmethoxy-N-(2-sulfamoylphenyl)benzamide

[0329]
A benzene (30 ml) solution containing 3.00 g (12.8 mmol) of 3-cyclohexylmethoxybenzoic acid and 3 ml of thionyl chloride was heated under reflux for 2 hours and then the solvent was evaporated under a reduced pressure. The resulting residue was dissolved in methylene chloride (30 ml), this solution was added dropwise under ice-cooling to a pyridine (50 ml) solution containing 2.43 g (14.1 mmol) of 2-aminobenzenesulfonamide, the mixture was stirred at room temperature for 18 hours and then methylene chloride was evaporated under a reduced pressure. The resulting residue was dissolved in ethyl acetate, washed with a 1 N hydrochloric acid aqueous solution, water and saturated brine in that order and dried over anhydrous sodium sulfate, and then the solvent was evaporated under a reduced pressure. The thus obtained crude crystals were recrystallized from acetonitrile to obtain 2.80 g (yield: 56.0%) of the title compound. [0330]
NMR (CDCl[0331] ₃) δ: 1.00-1.39 (5H, m), 1.68-1.90 (6H, m), 3.82 (2H, d, J=7 Hz), 4.95 (2H, s), 7.10 (1H, ddd, J=8 Hz, 2 Hz, 1 Hz), 7.25 (1H, ddd, J=8 Hz, 8 Hz, 1 Hz), 7.38 (1H, dd, J=8 Hz, 8 Hz), 7.45-7.50 (2H, m), 7.62 (1H, ddd, J=8 Hz, 8 Hz, 2 Hz), 7.96 (1H, dd, J=8 Hz, 2 Hz), 8.53 (1H, dd, J=8 Hz, 1 Hz), 10.03 (1H, s)
EI-MS (m/z, %): 388 (m+, 44), 217 (86), 212 (95), 121 (100) [0332]
IR (ν, cm[0333] ⁻¹, KBr): 1670, 1580, 1538, 1450, 1158, 1522, 1034
Melting point: 161-162° C. [0334]

EXAMPLE 26

N-[2-(3-Cyclohexylmethoxybenzamido)benzenesulfonyl acetamide

[0335]
In a stream of nitrogen and at 0° C., 0.11 ml (1.10 mmol) of acetic anhydride was added to an anhydrous tetrahydrofuran (10 ml) solution containing 400 mg (1.00 mmol) of 3-cyclohexylmethoxy-N-(2-sulfamoylphenyl)benzamide produced in Reference Example 7 and 237 mg (1.90 mmol) of 4-dimethylaminopyridine, the mixture was stirred at room temperature for 1 hour and then the solvent was evaporated under a reduced pressure. The resulting residue was dissolved in ethyl acetate, washed with water, a potassium hydrgensulfate aqueous solution and saturated brine in that order and dried over anhydrous sodium sulfate, and then the solvent was evaporated under a reduced pressure. The resulting residue was purified by a silica gel column chromatography to obtain 430 mg (yield: 96.9%) of the title compound. [0336]
NMR (CDCl[0337] ₃) δ: 1.00-1.13 (2H, m), 1.14-1.37 (3H, m), 1.66-1.92 (6H, m), 2.06 (3H, s), 3.83 (2H, d, J=6 Hz), 7.07-7.12 (1H, m), 7.22-7.29 (1H, m), 7.35-7.42 (1H, m), 7.54-7.60 (2H, m), 7.65-7.72 (1H, m), 7.98 (1H, dd, J=8 Hz, 1 Hz), 8.30 (1H, br-s), 8.73 (1H, dd, J=8 Hz, 1 Hz), 10.34 (1H, br-s)
IR (ν, cm[0338] ⁻¹, KBr): 3368, 3036, 2932, 2856, 1712, 1662, 1604, 1586, 1542, 1492, 1472, 1450, 1440
EI-MS (m/z, %): 430 (37), 308 (12), 275 (14), 183 (8), 121 (100) [0339]
Melting point: 164-167° C. [0340]

EXAMPLE 27

N-[2-(3-Cyclohexylmethoxybenzamido)benzenesulfonyl]hexanamide

[0341]
In a stream of nitrogen and at 0° C., 0.16 ml (1.10 mmol) of hexanoyl chloride was added to an anhydrous tetrahydrofuran (10 ml) solution containing 400 mg (1.00 mmol) of 3-cyclohexylmethoxy-N-(2-sulfamoylphenyl)benzamide produced in Reference Example 7 and 237 mg (1.90 mmol) of 4-dimethylaminopyridine, the mixture was stirred at room temperature for 1 hour and then the solvent was evaporated under a reduced pressure. The resulting residue was dissolved in ethyl acetate, washed with water, a potassium hydrgensulfate aqueous solution and saturated brine in that order and dried over anhydrous sodium sulfate, and then the solvent was evaporated under a reduced pressure. The resulting residue was purified by a silica gel column chromatography to obtain 490 mg (yield: 97.8%) of the title compound. [0342]
NMR (CDCl[0343] ₃) δ: 0.84 (3H, t, J=7 Hz), 1.00-1.13 (2H, m), 1.14 1.38 (7H, m), 1.50-1.61 (2H, m), 1.66-1.92 (6H, m), 2.23 (2H, t, J=7 Hz), 3.83 (2H, d, J=6 Hz), 7.07-7.12 (1H, m), 7.22-7.29 (1H, m), 7.36-7.42 (1H, m), 7.55-7.61 (2H, m), 7.65-7.71 (1H, m), 7.99 (1H, dd, J=8 Hz, 1 Hz), 8.11 (1H, br-s), 8.73 (1H, dd, J=8 Hz, 1 Hz), 10.40 (1H, br-s)
IR (ν, cm[0344] ⁻¹, KBr): 3380, 3080, 2924, 2856, 1714, 1690, 1664, 1580, 1538, 1476, 1448, 1406
EI-MS (m/z, %): 486 (46), 275 (14), 183 (8), 121 (100) [0345]
Melting point: 112-113° C. [0346]

EXAMPLE 28

N-[2-(3-Cyclohexylmethoxybenzamido)benzenesulfonyl]decanamide

[0347]
In a stream of nitrogen and at 0° C., 0.24 ml (1.10 mmol) of decanoyl chloride was added to an anhydrous tetrahydrofuran (10 ml) solution containing 400 mg (0.68 mmol) of 3-cyclohexylmethoxy-N-(2-sulfamoylphenyl)benzamide produced in Reference Example 7 and 237 mg (1.90 mmol) of 4-dimethylaminopyridine, the mixture was stirred at room temperature for 1 hour and then the solvent was evaporated under a reduced pressure. The resulting residue was dissolved in ethyl acetate, washed with water, a potassium hydrgensulfate aqueous solution and saturated brine in that order and dried over anhydrous sodium sulfate, and then the solvent was evaporated under a reduced pressure. The resulting residue was purified by a silica gel column chromatography to obtain 550 mg (yield: 98.4%) of the title compound. [0348]
NMR (CDCl[0349] ₃) δ: 0.87 (3H, t, J=7 Hz), 1.01-1.13 (2H, m), 1.15-1.37 (15H, m), 1.49-1.59 (2H, m), 1.66-1.92 (6H, m), 2.23 (2H, t, J=7 Hz), 3.83 (2H, d, J=6 Hz), 7.07-7.12 (1H, m), 7.22-7.29 (1H, m), 7.36-7.42 (1H, m), 7.55-7.62 (2H, m), 7.64-7.72 (1H, m), 7.99 (1H, dd, J=8 Hz, 1 Hz), 8.08 (1H, br-s), 8.73 (1H, dd, J=8 Hz, 1 Hz), 10.40 (1H, br-s)
IR (ν, cm[0350] ⁻¹, KBr): 3360, 3028, 2924, 2856, 1708, 1658, 1540, 1472, 1448
EI-MS (m/z, %): 542 (29), 275 (9), 183 (6), 121 (100) [0351]
Melting point: 124-127° C. [0352]

EXAMPLE 29

N-[2-[3-(4-t-Butylbenzyloxy)benzamido]benzenesulfonyl]acetamide

[0353]
In a stream of nitrogen and at 0° C., 0.11 ml (1.10 mmol) of acetic anhydride was added to an anhydrous tetrahydrofuran (10 ml) solution containing 438 mg (1.00 mmol) of 3-(4-t-butylbenzyloxy)-N-(2-sulfamoylphenyl)benzamide produced in Reference Example 2 and 249 mg (2.00 mmol) of 4-dimethylaminopyridine, the mixture was stirred at room temperature for 1 hour and then the solvent was evaporated under a reduced pressure. The resulting residue was dissolved in ethyl acetate, washed with water, a potassium hydrgensulfate aqueous solution and saturated brine in that order and dried over anhydrous sodium sulfate, and then the solvent was evaporated under a reduced pressure. The resulting residue was purified by a silica gel column chromatography to obtain 456 mg (yield: 96.0%) of the title compound. [0354]
NMR (CDCl[0355] ₃) δ: 1.29 (9H, s), 1.93 (3H, s), 5.15 (2H, s), 7.17 (1H, ddd, J=8 Hz, 2 Hz, 1 Hz), 7.22-7.29 (1H, m), 7.38-7.44 (5H, m), 7.60-7.63 (1H, m), 7.65-7.71 (2H, m), 7.99 (1H, dd, J=8 Hz, 2 Hz), 8.73 (1H, dd, J=8 Hz, 1 Hz), 7.56 (1H, d, J=7 Hz), 7.60 (1H, s), 7.72 (1H, m), 7.91 (1H, d, J=8 Hz), 8.40 (1H, d, J=8 Hz), 10.40 (1H, br-s)
EI-MS (m/z, %): 480 (m+, 26), 422 (1), 267 (4), 147 (100) [0356]
IR (ν, cm[0357] ⁻¹, KBr): 3384, 2956, 2868, 1714, 1658, 1580, 1538
Melting point: 190-191° C. [0358]

EXAMPLE 30

N-[2-[3-(4-t-Butylbenzyloxy)benzamido]benzenesulfonyl]hexanamide

[0359]
In a stream of nitrogen and at 0° C., 0.16 ml (1.10 mmol) of hexanoyl chloride was added to an anhydrous tetrahydrofuran (10 ml) solution containing 438 mg (1.00 mmol) of 3-(4-t-butylbenzyloxy)-N-(2-sulfamoylphenyl)benzamide produced in Reference Example 2 and 249 mg (2.00 mmol) of 4-dimethylaminopyridine, the mixture was stirred at room temperature for 1 hour and then the solvent was evaporated under a reduced pressure. The resulting residue was dissolved in ethyl acetate, washed with water, a potassium hydrgensulfate aqueous solution and saturated brine in that order and dried over anhydrous sodium sulfate, and then the solvent was evaporated under a reduced pressure. The resulting residue was purified by a silica gel column chromatography to obtain 488 mg (yield: 91.0%) of the title compound. [0360]
NMR (CDCl[0361] ₃) δ: 0.82 (3H, t, J=7 Hz), 1.21 (4H, m), 1.33 (9H, s), 1.54 (2H, m), 2.23 (2H, t, J=7 Hz), 5.10 (2H, s), 7.18 (1H, ddd, J=8 Hz, 2 Hz, 1 Hz), 7.26 (1H, ddd, J=8 Hz, 8 Hz, 2 Hz), 7.38-7.44 (5H, m), 7.62 (1H, d, J=8 Hz), 7.65-7.74 (2H, m), 7.96 (1H, br-s), 8.00 (1H, dd, J=8 Hz, 2 Hz), 8. 74 (1H, dd, J=8 Hz, 1 Hz), 10.43 (1H, br-s)
EI-MS (m/z, %): 536 (m+, 49), 422 (4), 267 (14), 147 (100), 91 (21), 71 (4) [0362]
IR (ν, cm[0363] ⁻¹, KBr): 3368, 2960, 2868, 1702, 1662, 1586, 1538
Melting point: 163-164° C. [0364]

EXAMPLE 31

N-[2-[3-(4-t-Butylbenzyloxy)benzamido]benzenesulfonyl]decanamide

[0365]
In a stream of nitrogen and at 0° C., 0.24 ml (1.10 mmol) of decanoyl chloride was added to an anhydrous tetrahydrofuran (10 ml) solution containing 438 mg (1.00 mmol) of 3-(4-t-butylbenzyloxy)-N-(2-sulfamoylphenyl)benzamide produced in Reference Example 2 and 249 mg (2. 00 mmol) of 4-dimethylaminopyridine, the mixture was stirred at room temperature for 1 hour and then the solvent was evaporated under a reduced pressure. The resulting residue was dissolved in ethyl acetate, washed with water, a potassium hydrgensulfate aqueous solution and saturated brine in that order and dried over anhydrous sodium sulfate, and then the solvent was evaporated under a reduced pressure. The resulting residue was purified by a silica gel column chromatography to obtain 535 mg (yield: 99. 0%) of the title compound. [0366]
NMR (CDCl[0367] ₃) δ: 0.86 (3H, t, J=7 Hz), 1.22 (14H, m), 1.33 (9H, s), 2.23 (2H, t, J=7 Hz), 5.10 (2H, s), 7.18 (1H, ddd, J=8 Hz, 2 Hz, 1 Hz), 7.26 (1H, ddd, J=8 Hz, 8 Hz, 2 Hz), 7.38-7.44 (5H, m), 7.62 (1H, d, J=8 Hz), 7.65-7.74 (2H, m), 7.94 (1H, br-s), 8.00 (1H, dd, J=8 Hz, 2 Hz), 8.74 (1H, dd, J=8 Hz, 1 Hz), 10.43 (1H, br-s)
EI-MS (m/z, %): 592 (m+, 30), 422 (3), 267 (16), 147 (100) [0368]
IR (ν, cm[0369] ⁻¹, KBr): 3368, 3064, 3036, 2960, 2924, 2856, 1704, 1660, 1586, 1540
Melting point: 132-133° C. [0370]

REFERENCE EXAMPLE 8

3-(4-Trifluoromethylbenzyloxy)-N-(2-sulfamoylphenyl)benzamide

[0371]
A benzene (30 ml) solution containing 4.00 g (14.1 mmol) of 3-(4-trifluoromethylbenzyloxy)benzoic acid and 3 ml of thionyl chloride was heated under reflux for 2 hours and then the solvent was evaporated under a reduced pressure. The resulting residue was dissolved in methylene chloride (30 ml), this solution was added dropwise under ice-cooling to a pyridine (50 ml) solution containing 2.66 g (15.4 mmol) of 2-aminobenzenesulfonamide, the mixture was stirred at room temperature for 18 hours and then methylene chloride was evaporated under a reduced pressure. The resulting residue was dissolved in ethyl acetate, washed with a 1 N hydrochloric acid aqueous solution, water and saturated brine in that order and dried over anhydrous sodium sulfate, and then the solvent was evaporated under a reduced pressure. The thus obtained crude crystals were washed with methanol to obtain 5.10 g (yield: 80.0%) of the title compound. [0372]
NMR (DMSO-d[0373] ₆) δ: 5.33 (2H, s), 7.29-7.36 (2H, m), 7.50-7.58 (3H, m), 7.65 (1H, ddd, J=8 Hz, 8 Hz, 2 Hz), 7.69 (2H, d, J=8 Hz), 7.78 (2H, d, J=8 Hz), 7.90 (1H, dd, J=8 Hz, 2 Hz), 8.47 (1H, dd, J=8 Hz, 1 Hz)
EI-MS (m/z, %): 450 (m+, 68), 371 (100), 279 (100), 159 (100) [0374]
IR (ν, cm[0375] ⁻¹, KBr): 1678, 1586, 1538, 1326, 1066
Melting point: 169-170° C. [0376]

EXAMPLE 32

N-[2-[3-(4-Trifluoromethylbenzyloxy)benzamido]benzenesulfonyl]acetamide

[0377]
In a stream of nitrogen and at 0° C., 0.11 ml (1.10 mmol) of acetic anhydride was added to an anhydrous tetrahydrofuran (10 ml) solution containing 451 mg (1.00 mmol) of 3-(4-trifluoromethylbenzyloxy)-N-(2-sulfamoylphenyl)benzamide produced in Reference Example 8 and 249 mg (2.00 mmol) of 4-dimethylaminopyridine, the mixture was stirred at room temperature for 1 hour and then the solvent was evaporated under a reduced pressure. The resulting residue was dissolved in ethyl acetate, washed with water, a potassium hydrgensulfate aqueous solution and saturated brine in that order and dried over anhydrous sodium sulfate, and then the solvent was evaporated under a reduced pressure. The resulting residue was purified by a silica gel column chromatography to obtain 476 mg (yield: 96.7%) of the title [0378]
NMR (CDCl[0379] ₃) δ: 2.05 (3H, s), 5.21 (2H, s), 7.16 (1H, ddd, J=8 Hz, 2 Hz, 1 Hz), 7.26 (1H, ddd, J=8 Hz, 8 Hz, 2 Hz), 7.42 (1H, dd, J=8 Hz, 8 Hz), 7.57 (2H, d, J=8 Hz), 7.65-7.74 (5H, m), 7.96 (1H, dd, J=8 Hz, 2 Hz), 8.30 (1H, br-s), 8.73 (1H, dd, J=8 Hz, 1 Hz), 10.44 (1H, br-s)
EI-MS (m/z, %): 492 (m+, 3), 370 (35), 279 (92), 159 (100), 121 (22) [0380]
IR (ν, cm[0381] ⁻¹, KBr): 3372, 3124, 2880, 1724, 1678, 1614, 1588, 1546
Melting point: 164-165° C. [0382]

EXAMPLE 33

N-[2-[3-(4-Trifluoromethylbenzyloxy)benzamido]benzenesulfonyl]hexanamide

[0383]
In a stream of nitrogen and at 0° C., 0.16 ml (1.10 mmol) of hexanoyl chloride was added to an anhydrous tetrahydrofuran (10 ml) solution containing 451 mg (1.00 mmol) of 3-(4-trifluoromethylbenzyloxy)-N-(2-sulfamoylphenyl)benzamide produced in Reference Example 8 and 249 mg (2.00 mmol) of 4-dimethylaminopyridine, the mixture was stirred at room temperature for 1 hour and then the solvent was evaporated under a reduced pressure. The resulting residue was dissolved in ethyl acetate, washed with water, a potassium hydrgensulfate aqueous solution and saturated brine in that order and dried over anhydrous sodium sulfate, and then the solvent was evaporated under a reduced pressure. The resulting residue was purified by a silica gel column chromatography to obtain 439 mg (yield: 80.0%) of the title compound. [0384]
NMR (CDCl[0385] ₃) δ: 0.82 (3H, t, J=7 Hz), 1.21 (4H, m), 1.55 (2H, m), 2.23 (2H, t, J=7 Hz), 5.21 (2H, s), 7.17 (1H, ddd, J=8 Hz, 2 Hz, 1 Hz), 7.26 (1H, ddd, J=8 Hz, 8 Hz, 2 Hz), 7.43 (1H, dd, J=8 Hz, 8 Hz), 7.57 (2H, d, J=8 Hz), 7.63-7.72 (5H, m), 7.98 (1H, dd, J=8 Hz, 2 Hz), 8.02 (1H, br-s), 8.74 (1H, dd, J=8 Hz, 1 Hz), 10.46 (1H, br-s)
EI-MS (m/z, %): 548 (m+, 25), 370 (50), 279 (100), 159 (96), 121 (25) [0386]
IR (ν, cm[0387] ⁻¹, KBr): 3380, 3080, 2960, 2932, 2872, 1708, 1660, 1584, 1540
Melting point: 142-143° C. [0388]

EXAMPLE 34

N-[2-[3-(4-Trifluoromethylbenzyloxy)benzamido]benzenesulfonyl]decanamide

[0389]
In a stream of nitrogen and at 0° C., 0.24 ml (1.10 mmol) of decanoyl chloride was added to an anhydrous tetrahydrofuran (10 ml) solution containing 451 mg (1.00 mmol) of 3-(4-trifluoromethylbenzyloxy)-N-(2-sulfamoylphenyl)benzamide produced in Reference Example 8 and 249 mg (2.00 mmol) of 4-dimethylaminopyridine, the mixture was stirred at room temperature for 1 hour and then the solvent was evaporated under a reduced pressure. The resulting residue was dissolved in ethyl acetate, washed with water, a potassium hydrgensulfate aqueous solution and saturated brine in that order and dried over anhydrous sodium sulfate, and then the solvent was evaporated under a reduced pressure. The resulting residue was purified by a silica gel column chromatography to obtain 512 mg (yield: 84.6%) of the title compound. [0390]
NMR (CDCl[0391] ₃) δ: 0.86 (3H, t, J=7 Hz), 1.16-1.28 (12H, m), 1.53 (2H, m), 2.23 (2H, t, J=7 Hz), 5.21 (2H, s), 7.16 (1H, ddd, J=8 Hz, 2 Hz, 1 Hz), 7.26 (1H, ddd, J=8 Hz, 8 Hz, 2 Hz), 7.43 (1H, dd, J=8 Hz, 8 Hz), 7.58 (2H, d, J=8 Hz), 7.63-7.73 (5H, m), 7.97 (1H, dd, J=8 Hz, 2 Hz), 8.25 (1H, br-s), 8.73 (1H, dd, J=8 Hz, 1 Hz), 10.47 (1H, br-s)
EI-MS (m/z, %): 604 (m+, 28), 370 (57), 279 (100), 159 (82) [0392]
IR (ν, cm[0393] ⁻¹, KBr): 3372, 3036, 2924, 2852, 2788, 1702, 1666, 1606, 1588, 1544
Melting point: 164° C. [0394]

REFERENCE EXAMPLE 9

3-Heptyloxy-N-(2-sulfamoylphenyl)benzamide

[0395]
A benzene (30 ml) solution containing 3 g (12.5 mmol) of 3-heptyloxybenzoic acid and 3 ml of thionyl chloride was heated under reflux for 2 hours and then the solvent was evaporated under a reduced pressure. The resulting residue was dissolved in methylene chloride (30 ml), this solution was added dropwise under ice-cooling to a pyridine (50 ml) solution containing 2.50 g (14.5 mmol) of 2-aminobenzenesulfonamide, the mixture was stirred at room temperature for 18 hours and then methylene chloride was evaporated under a reduced pressure. The resulting residue was dissolved in ethyl acetate, washed with a 1 N hydrochloric acid aqueous solution, water and saturated brine in that order and dried over anhydrous sodium sulfate, and then the solvent was evaporated under a reduced pressure. The thus obtained crude crystals were recrystallized from acetonitrile to obtain 3.00 g (yield: 60.0%) of the title compound. [0396]
NMR (DMSO-d[0397] ₆) δ: 0.87 (3H, t, J=7 Hz), 1.22-1.50 (8H, m), 1.70-1.80 (2H, m), 4.41 (2H, t, J=7 Hz), 7.17-7.23 (1H, m), 7.33 (1H, ddd, J=8 Hz, 8 Hz, 2 Hz), 7.77 (2H, s), 7.90 (1H, dd, J=8 Hz, 2 Hz), 8.48 (1H, d, J=8 Hz), 10.38 (1H, s)
EI-MS (m/z, %): 390 (m+, 82), 311 (43), 310 (100), 219 (100) [0398]
IR (ν, cm[0399] ⁻¹, KBr): 1674, 1612, 1586, 1544, 1336, 1140
Melting point: 112-113° C. [0400]

EXAMPLE 35

N-[2-(3-Heptyloxybenzamido)benzenesulfonyl]acetamide

[0401]
In a stream of nitrogen and at 0° C., 0.11 ml (1.10 mmol) of acetic anhydride was added to an anhydrous tetrahydrofuran (10 ml) solution containing 391 mg (1.00 mmol) of 3-heptyloxy-N-(2-sulfamoylphenyl)benzamide produced in Reference Example 9 and 249 mg (2.00 mmol) of 4-dimethylaminopyridine, the mixture was stirred at room temperature for 1 hour and then the solvent was evaporated under a reduced pressure. The resulting residue was dissolved in ethyl acetate, washed with water, a potassium hydrgensulfate aqueous solution and saturated brine in that order and dried over anhydrous sodium sulfate, and then the solvent was evaporated under a reduced pressure. The resulting residue was purified by a silica gel column chromatography to obtain 411 mg (yield: 95.0%) of the title compound. [0402]
NMR (DMSO-d[0403] ₆) δ: 0.87 (3H, t, J=7 Hz), 1.35 (8H, m), 1.68 (3H, s), 1.75 (2H, m), 4.04 (2H, t, J=6 Hz), 7.10-7.15 (2H, m), 7.38-7.46 (2H, m), 7.57-7.64 (2H, m), 7.75 (1H, dd, J=8 Hz, 2 Hz), 8.34 (1H, dd, J=8 Hz, 1 Hz), 11.51 (1H, s)
EI-MS (m/z, %): 432 (m+, 7), 310 (31), 219 (100), 121 (12) [0404]
IR (ν, cm[0405] ⁻¹, KBr): 2928, 2856, 1684, 1586, 1552, 1494
Melting point: 194-195° C. [0406]

EXAMPLE 36

N-[2-(3-Heptyloxybenzamido)benzenesulfonyl]hexanamide

[0407]
In a stream of nitrogen and at 0° C., 0.16 ml (1.10 mmol) of hexanoyl chloride was added to an anhydrous tetrahydrofuran (10 ml) solution containing 390 mg (1.00 mmol) of 3-heptyloxy-N-(2-sulfamoylphenyl)benzamide produced in Reference Example 9 and 249 mg (2.00 mmol) of 4-dimethylaminopyridine, the mixture was stirred at roam temperature for 1 hour and then the solvent was evaporated under a reduced pressure. The resulting residue was dissolved in ethyl acetate, washed with water, a potassium hydrgensulfate aqueous solution and saturated brine in that order and dried over anhydrous sodium sulfate, and then the solvent was evaporated under a reduced pressure. The resulting residue was purified by a silica gel column chromatography to obtain 412 mg (yield: 84.4%) of the title compound. [0408]
NMR (DMSO-d[0409] ₆) δ: 0.76 (3H, t, J=7 Hz), 0.87 (3H, d, J=7 Hz), 1.12 (4H, m), 1.26-1.47 (10H, m), 1.75 (2H, m), 1.92 (2H, m), 4.03 (2H, t, J=6 Hz), 7.10-7.15 (2H, m), 7.38-7.46 (2H, m), 7.58 (1H, ddd, J=8 Hz, 2 Hz, 1 Hz), 7.65 (1H, dd, J=2 Hz, 1 Hz), 7.74 (1H, dd, J=8 Hz, 2 Hz), 8.34 (1H, dd, J=8 Hz, 1 Hz), 11.46 (1H, s)
EI-MS (m/z, %): 488 (m+, 2), 310 (12), 219 (69), 196 (100), 121 (40) [0410]
IR (ν, cm[0411] ⁻¹, KBr): 2928, 2860, 1684, 1594, 1552, 1494
Melting point: 200-201° C. [0412]

EXAMPLE 37

N-[2-(3-Heptyloxybenzamido]benzenesulfonyl]decanamide

[0413]
In a stream of nitrogen and at 0° C., 0.24 ml (1.10 mmol) of decanoyl chloride was added to an anhydrous tetrahydrofuran (10 ml) solution containing 390 mg (1.00 mmol) of 3-heptyloxy-N-(2-sulfamoylphenyl)benzamide produced in Reference Example 9 and 249 mg (2.00 mmol) of 4-dimethylaminopyridine, the mixture was stirred at room temperature for 1 hour and then the solvent was evaporated under a reduced pressure. The resulting residue was dissolved in ethyl acetate, washed with water, a potassium hydrgensulfate aqueous solution and saturated brine in that order and dried over anhydrous sodium sulfate, and then the solvent was evaporated under a reduced pressure. The resulting residue was purified by a silica gel column chromatography to obtain 495 mg (yield: 91.0%) of the title compound. [0414]
NMR (DMSO-d[0415] ₆) δ: 0.84 (6H, m), 1.04-1.47 (2H, m), 1.75 (2H, m), 1.91 (2H, t, J=7 Hz), 4.04 (2H, t, J=6 Hz), 7.10-7.15 (2H, m), 7.38-7.46 (2H, m), 7.58 (1H, d, J=8 Hz), 7.66 (1H, dd, J=2 Hz, 1 Hz), 7.74 (1H, dd, J=8 Hz, 2 Hz), 8.34 (1H, dd, J=8 Hz, 1 Hz), 11.43 (1H, s)
EI-MS (m/z, %): 544 (m+, 2), 310 (21), 219 (100), 121 (36) [0416]
IR (ν, cm[0417] ⁻¹, KBr): 2928, 2856, 1684, 1592, 1552, 1494
Melting point: 172-174° C. [0418]

REFERENCE EXAMPLE 10

4-Phenylethynyl-N-(2-sulfamoylphenyl)benzamide

[0419]
A benzene (30 ml) solution containing 3.00 g (13.5 mmol) of 4-phenylethynylbenzoic acid and 2 ml of thionyl chloride was heated under reflux for 2 hours and then the solvent was evaporated under a reduced pressure. The resulting residue was dissolved in methylene chloride (30 ml), this solution was added dropwise under ice-cooling to a pyridine (50 ml) solution containing 2.32 g (13.50 mmol) of 2-aminobenzenesulfonamide, the mixture was stirred at room temperature for 18 hours and then methylene chloride was evaporated under a reduced pressure. The resulting residue was dissolved in ethyl acetate, washed with a 1 N hydrochloric acid aqueous solution, water and saturated brine in that order and dried over anhydrous sodium sulfate, and then the solvent was evaporated under a reduced pressure. The resulting residue was recrystallized from ethyl acetate-hexane to obtain 4.00 g (yield: 78.7%) of the title compound. [0420]
NMR (DMSO-d[0421] ₆) δ: 7.34-7.39 (1H, m), 7.44-7.50 (3H, m), 7.58-7.70 (3H, m), 7.77 (2H, d, J=8 Hz), 7.92 (1H, dd, J=8 Hz, 1 Hz), 7.97 (2H, d, J=8 Hz), 8.44 (1H, d, J=8 Hz), 10.50 (1H, br-s)

EXAMPLE 38

N-[2-(4-Phenylethynylbenzamido)benzenesulfonyl]acetamide

[0422]
In a stream of nitrogen and at 0° C., 0.15 ml (1.60 mmol) of acetic anhydride was added to an anhydrous tetrahydrofuran (10 ml) solution containing 500 mg (1.30 mmol) of 4-phenylethynyl-N-(2-sulfamoylphenyl)benzamide produced in Reference Example 10 and 320 mg (2.60 mmol) of 4-dimethylaminopyridine, the mixture was stirred at room temperature for 1 hour and then the solvent was evaporated under a reduced pressure. The resulting residue was dissolved in ethyl acetate, washed with water, a potassium hydrgensulfate aqueous solution and saturated brine in that order and dried over anhydrous sodium sulfate, and then the solvent was evaporated under a reduced pressure. The resulting residue was recrystallized from methanol to obtain 430 mg (yield: 77.6%) of the title compound. [0423]
NMR (CDCl[0424] ₃) δ: 2.07 (3H, s), 7.24-7.30 (1H, m), 7.34-7.40 (3H, m), 7.53-7.60 (2H, m), 7.65 (2H, d, J=8 Hz), 7.66-7.72 (1H, m), 7.99 (1H, dd, J=8, 1 Hz), 8.03 (2H, d, J=8 Hz), 8.42 (1H, dd, J=8, 1 Hz), 10.47 (1H, s)
IR (ν, cm[0425] ⁻¹, KBr): 3384, 1712, 1658, 1588, 1538, 1342, 1172, 764
EI-MS (m/z, %): 418 (m+, 25), 296 (13), 267 (3), 205 (100), 176 (22) [0426]
Melting point: 214-215° C. [0427]

EXAMPLE 39

N-[2-(4-Phenylethynylbenzamido)benzenesulfonyl]acetamide

[0428]
In a stream of nitrogen and at 0° C., 0.20 ml (1.46 mmol) of hexanoyl chloride was added to an anhydrous tetrahydrofuran (10 ml) solution containing 500 mg (1.30 mmol) of 4-phenylethynyl-N-(2-sulfamoylphenyl)benzamide produced in Reference Example 10 and 320 mg (2.60 mmol) of 4-dimethylaminopyridine, the mixture was stirred at room temperature for 1 hour and then the solvent was evaporated under a reduced pressure. The resulting residue was dissolved in ethyl acetate, washed with water, a potassium hydrgensulfate aqueous solution and saturated brine in that order and dried over anhydrous sodium sulfate, and then the solvent was evaporated under a reduced pressure. The resulting residue was purified by a silica gel column chromatography to obtain 460 mg (yield: 74.6%) of the title compound. [0429]
NMR (CDCl[0430] ₃) δ: 0.84 (3H, t, J=7 Hz), 1.16 1.30 (4H, m), 1.52-1.60 (2H, m), 2.24 (2H, t, J=7 Hz), 7.24-7.29 (1H, m), 7.35-7.40 (3H, m), 7.54-7.59 (2H, m), 7.65 (2H, d, J=8 Hz), 7.66-7.72 (1H, m), 7.98 (1H, dd, J=8 Hz, 1 Hz), 8.04 (2H, d, J=8 Hz), 8.16 (1H, br-s), 8.74 (1H, dd, J=8 Hz, 1 Hz), 10.49 (1H, s)
IR (ν, cm[0431] ⁻¹, KBr): 3372, 2956, 1712, 1662, 1590, 1440, 1340, 1142, 766 EI-MS (m/z, %): 474 (m+, 22), 376 (3), 296 (16), 267 (3), 205 (100), 176 (17)
Melting point: 175-176° C. [0432]

EXAMPLE 40

N-[2-(4-Phenylethynylbenzamido)benzenesulfonyl]decanamide

[0433]
In a stream of nitrogen, 0.30 ml (1.46 mmol) of decanoyl chloride was added to an anhydrous tetrahydrofuran (10 ml) solution containing 500 mg (1.30 mmol) of 4-phenylethynyl-N-(2-sulfamoylphenyl)benzamide produced in Reference Example 10 and 320 mg (2.60 mmol) of 4-dimethylaminopyridine, the mixture was stirred at room temperature for 1 hour and then the solvent was evaporated under a reduced pressure. The resulting residue was dissolved in ethyl acetate, washed with water, a potassium hydrgensulfate aqueous solution and saturated brine in that order and dried over anhydrous sodium sulfate, and then the solvent was evaporated under a reduced pressure. The resulting residue was purified by a silica gel column chromatography to obtain 540 mg (yield: 76.4%) of the title compound. [0434]
NMR (CDCl[0435] ₃) δ: 0.86 (3H, t, J=7 Hz), 1.18-1.32 (12H, m), 1.50-1.62 (4H, m), 2.24 (2H, t, J=7 Hz), 7.24-7.29 (1H, m), 7.35-7.40 (3H, m), 7.54-7.58 (2H, m), 7.65 (2H, d, J=8 Hz), 7.66-7.72 (1H, m), 7.98 (1H, dd, J=8 Hz, 1 Hz), 8.04 (2H, d, J=8 Hz), 8.16 (1H, br-s), 8.74 (1H, dd, J=8 Hz, 1 Hz), 10.49 (1H, s)
IR (ν, cm[0436] ⁻¹, KBr): 3368, 2956, 1712, 1660, 1588, 1540, 1442, 1340, 1144, 764
EI-MS (m/z, %): 530 (m+, 21), 376 (5), 296 (18), 267 (3), 205 (100), 176 (14) [0437]
Melting point: 155-156° C. [0438]

EXAMPLE 41

N-[2-(4-Phenylethynylbenzamido)benzenesulfonyl]pivalamide

[0439]
In a stream of nitrogen and at 0° C., 0.16 ml (1.31 mmol) of pivaloyl chloride was added to an anhydrous tetrahydrofuran (10 ml) solution containing 400 mg (1.06 mmol) of 4-phenylethynyl-N-(2-sulfamoylphenyl)benzamide produced in Reference Example 10 and 260 mg (2.12 mmol) of 4-dimethylaminopyridine, the mixture was stirred at room temperature for 1 hour and then the solvent was evaporated under a reduced pressure. The resulting residue was dissolved in ethyl acetate, washed with water, a potassium hydrgensulfate aqueous solution and saturated brine in that order and dried over anhydrous sodium sulfate, and then the solvent was evaporated under a reduced pressure. The resulting residue was purified by a silica gel column chromatography to obtain 360 mg (yield: 73.0%) of the title compound. [0440]
NMR (CDCl[0441] ₃) δ: 1.15 (9H, s), 7.27 (1H, ddd, J=8 Hz, 8 Hz, 2 Hz), 7.32-7.42 (3H, m), 7.52-7.60 (2H, m), 7.65-7.72 (3H, m), 7.97 (1H, dd, J=8 Hz, 2 Hz), 8.04 (2H, dd, J=9 Hz, 2 Hz), 8.23 (1H, br-s), 8.73 (1H, dd, J=8 Hz, 2 Hz), 10.47 (1H, s)
IR (ν, cm[0442] ⁻¹, KBr): 2220, 1712, 1680, 1606, 1588, 1532, 1474, 1440, 1256, 1108
EI-MS (m/z, %): 460 (m+, 55), 296 (34), 205 (100), 176 (30) [0443]
Melting point: 236-237° C. [0444]

EXAMPLE 42

3-Methyl-N-[2-(4-phenylethynylbenzamido)benzenesulfonyl]-2-butenamide

[0445]
In a stream of nitrogen and at 0° C., 0.10 ml (0.96 mmol) of 3,3-dimethylacryloyl chloride was added to an anhydrous tetrahydrofuran (10 ml) solution containing 300 mg (0.80 mmol) of 4-phenylethynyl-N-(2-sulfamoylphenyl)benzamide produced in Reference Example 10 and 195 mg (1.60 mmol) of 4-dimethylaminopyridine, the mixture was stirred at room temperature for 1 hour and then the solvent was evaporated under a reduced pressure. The resulting residue was dissolved in ethyl acetate, washed with water, a potassium hydrgensulfate aqueous solution and saturated brine in that order and dried over anhydrous sodium sulfate, and then the solvent was evaporated under a reduced pressure. The resulting residue was purified by a silica gel column chromatography to obtain 183 mg (yield: 50.0%) of the title compound. [0446]
NMR (CDCl[0447] ₃) δ: 1.55 (3H, s), 1.88 (3H, s), 5.51 (1H, s), 7.27 (1H, ddd, J=8 Hz, 8 Hz, 2 Hz), 7.37-7.41 (3H, m), 7.55-7.59 (2H, m), 7.64-7.60 (3H, m), 7.93 (1H, br-s), 8.00 (1H, dd, J=8 Hz, 2 Hz), 8.07 (2H, dd, J=8 Hz, 2 Hz), 8.72 (1H, dd, J=8 Hz, 2 Hz), 10.60 (1H, s)
IR (ν, cm[0448] ⁻¹, KBr): 2216, 1698, 1684, 1658, 1644, 1608, 1442, 1334, 1300, 1118
EI-MS (m/z, %): 458 (m+, 65), 376 (15), 296 (39), 205 (100), 176 (52) [0449]
Melting point: 187-188° C. [0450]

EXAMPLE 43

trans-N-[2-(4-Phenylethynylbenzamido)benzenesulfonyl]-2,4-hexadienamide

[0451]
In a stream of nitrogen and at 0° C., 0.10 ml (0.96 mmol) of 2,4-hexadienoyl chloride was added to an anhydrous tetrahydrofuran (10 ml) solution containing 300 mg (0.80 mmol) of 4-phenylethynyl-N-(2-sulfamoylphenyl)benzamide produced in Reference Example 10 and 195 mg (1.60 mmol) of 4-dimethylaminopyridine, the mixture was stirred at room temperature for 1 hour and then the solvent was evaporated under a reduced pressure. The resulting residue was dissolved in ethyl acetate, washed with water, a potassium hydrgensulfate aqueous solution and saturated brine in that order and dried over anhydrous sodium sulfate, and then the solvent was evaporated under a reduced pressure. The thus formed crude crystals were recrystallized from methanol to obtain 180 mg (yield: 48.0%) of the title compound. [0452]
NMR (CDCl[0453] ₃) δ: 1.86 (3H, d, J=6 Hz), 5.65 (1H, d, J=15 Hz), 6.10-6.26 (2H, m), 7.22-7.30 (2H, m), 7.34-7.40 (3H, m), 7.54-7.59 (2H, m), 7.64-7.70 (3H, m), 7.99 (1H, dd, J=8 Hz, 2 Hz), 8.02 (1H, br-s), 8.06-8.10 (2H, m), 8.75 (1H, dd, J=8 Hz, 2 Hz), 10.61 (1H, s)
IR (ν, cm[0454] ⁻¹, KBr): 2220, 1698, 1668, 1640, 1590, 1538, 1474, 1440, 1346, 1160
EI-MS (m/z, %): 470 (m+, 39), 360 (24), 296 (40), 205 (100), 176 (100), 151 (42) [0455]
Melting point: 208-209° C. [0456]

EXAMPLE 44

trans-N-[2-(4-Phenylethynylbenzamido)benzenesulfonyl]-3-hexenamide

[0457]
In a stream of nitrogen and at 0° C., 249 mg (1.30 mmol) of tosylic chloride was added to an anhydrous tetrahydrofuran (10 ml) solution containing 149 mg (1.30 mmol) of 3-hexenoic acid and 532 mg (4.35 mmol) of 4-dimethylaminopyridine, and the mixture was stirred for 1 hour. Next, this was mixed with 300 mg (0.80 ml) of 4-phenylethynyl-N-(2-sulfamoylphenyl)benzamide produced in Reference Example 10 and stirred at room temperature for 1 hour, and then the solvent was evaporated under a reduced pressure. The resulting residue was dissolved in ethyl acetate, washed with water, a potassium hydrgensulfate aqueous solution and saturated brine in that order and dried over anhydrous sodium sulfate, and then the solvent was evaporated under a reduced pressure. The resulting residue was purified by a silica gel chromatography to obtain 250 mg (yield: 65.0%) of the title compound. [0458]
NMR (CDCl[0459] ₃) δ: 0.97 (3H, t, J=7 Hz), 2.00-2.10 (2H, m), 2.98 (2H, d, J=7 Hz), 5.34-5.42 (1H, m), 5.65-5.72 (1H, m), 7.27 (1H, ddd, J=8 Hz, 8 Hz, 2 Hz), 7.35-7.41 (3H, m), 7.53-7.59 (2H, m), 7.63-7.72 (3H, m), 7.97 (1H, dd, J=8 Hz, 2 Hz), 8.04 (2H, dd, J=8 Hz, 2 Hz), 8.23 (1H, br-s), 8.73 (1H, dd, J=8 Hz, 2 Hz), 10.45 (1H, s)
IR (ν, cm[0460] ⁻¹, KBr): 2220, 1718, 1660, 1602, 1590, 1538, 1444, 1430, 1340, 1128
EI-MS (m/z, %): 470 (m+, 71), 360 (19), 296 (39), 205 (100), 176 (76), 151 (32) [0461]
Melting point: 185.5-186.5° C. [0462]

EXAMPLE 45

3-Benzyloxy-N-[2-[(phenyloxycarbonylamino)sulfonyl]phenyl]benzamide

[0463]
In a stream of nitrogen and at 0° C., 0.36 ml (2.87 mmol) of phenyl chlorocarbonate was added to an anhydrous tetrahydrofuran (10 ml) solution containing 1 g (2.60 mmol) of 3-benzyloxy-N-(2-sulfamoylphenyl)benzamide produced in Reference Example 1 and 702 mg (5.75 mmol) of 4-dimethylaminopyridine, the mixture was stirred at room temperature for 1 hour and then the solvent was evaporated under a reduced pressure. The resulting residue was dissolved in ethyl acetate, washed with water, a potassium hydrgensulfate aqueous solution and saturated brine in that order and dried over anhydrous sodium sulfate, and then the solvent was evaporated under a reduced pressure. The resulting residue was recrystallized from acetonitrile to obtain 1.00 g (yield: 77.0%) of the title compound. [0464]
NMR (CDCl[0465] ₃) δ: 5.10 (2H, s), 6.98-7.01 (2H, m), 7.14-7.21 (2H, m), 7.24-7.32 (4H, m), 7.33-7.46 (5H, m), 7.55 (1H, ddd, J=8 Hz, 2 Hz, 1 Hz), 7.60 (1H, dd, J=2 Hz, 1 Hz), 7.71 (1H, ddd, J=8, 8, 2 Hz), 7.80 (1H, br-s), 8.07 (1H, dd, J=8 Hz, 2 Hz), 8.78 (1H, dd, J=8 Hz, 1 Hz), 10.33 (1H, s)
IR (ν, cm[0466] ⁻¹, KBr): 1762, 1664, 1582, 1534, 1462, 1442, 1360, 1164
FAB-MS (neg: m/z, %): 501 ([M—H]+27), 407 (38), 381 (100) [0467]
Melting point: 163-164° C. [0468]

EXAMPLE 46

3-Benzyloxy-N-[2-[[(butylamino)carbonylamino]sulfonyl]phenyl]benzamide

[0469]
A benzene (10 ml) solution containing 200 mg (0.40 mmol) of 3-benzyloxy-N-[2-[(phenyloxycarbonylamino)sulfonyl]phenyl]benzamide produced in Example 45 and 0.09 ml (0.88 mmol) of butylamine was heated under reflux for 2 hours. The reaction mixture was dissolved in ethyl acetate, washed with water, a potassium hydrgensulfate aqueous solution and saturated brine in that order and dried over anhydrous sodium sulfate, and then the solvent was evaporated under a reduced pressure. The resulting residue was recrystallized from acetonitrile to obtain 130 mg (yield: 68.0%) of the title compound. [0470]
NMR (CDCl[0471] ₃) δ: 0.83 (3H, t, J=7 Hz), 1.14-1.29 (2H, m), 1.31-1.37 (2H, m), 2.98 (2H, dt, J=7, 7 Hz), 5.14 (2H, s), 6.11 (1H, br-s), 7.16 (1H, ddd, J=8 Hz, 2 Hz, 1 Hz), 7.23 (1H, ddd, J=8 Hz, 8 Hz, 1 Hz), 7.31-7.42 (5H, m), 7.45 (2H, dd, J=8, 2 Hz), 7.53 (1H, d, J=8 Hz), 7.63-7.69 (2H, m), 7.85 (1H, dd, J=8 Hz, 2 Hz), 8.38 (1H, br-s), 8.70 (1H, dd, J=8 Hz, J=1 Hz), 10.13 (1H, s)
IR (ν, cm[0472] ⁻¹, KBr): 1698, 1650, 1580, 1538, 1484, 1450, 1330, 1166
FAB-MS (neg: m/z, %): 480 ([M—H]+100), 381 (27) [0473]
Melting point: 177-178° C. [0474]

EXAMPLE 47

3-Benzyloxy-N-[2-[[(octylamino)carbonylamino]sulfonyl]phenyl]benzamide

[0475]
A benzene (10 ml) solution containing 200 mg (0.40 mmol) of 3-benzyloxy-N-[2-[(phenyloxycarbonylamino)sulfonyl]phenyl]benzamide produced in Example 45 and 0.15 ml (0.88 mmol) of octylamine was heated under reflux for 2 hours. The reaction mixture was dissolved in ethyl acetate, washed with water, a potassium hydrgensulfate aqueous solution and saturated brine in that order and dried over anhydrous sodium sulfate, and then the solvent was evaporated under a reduced pressure. The resulting residue was purified by a silica gel chromatography to obtain 210 mg (yield: 98.0%) of the title compound. [0476]
NMR (CDCl[0477] ₃) δ: 0.88 (3H, t, J=7 Hz), 1.10-1.40 (12H, m), 3.00 (2H, dt, J=7, 7 Hz), 5.14 (2H, s), 6.15 (1H, br-s), 7.17 (1H, ddd, J=8 Hz, 2 Hz, 1 Hz), 7.23 (1H, ddd, J=8 Hz, 8 Hz, 1 Hz), 7.31-7.42 (5H, m), 7.46 (2H, d, J=8 Hz), 7.53 (1H, d, J=8 Hz), 7.62-7.70 (2H, m), 7.86 (1H, dd, J=8 Hz, 2 Hz), 8.07 (1H, br-s), 8.71 (1H, d, J=8 Hz), 10.11 (1H, s)
IR (ν, cm[0478] ⁻¹, KBr): 1702, 1650, 1580, 1540, 1450, 1356, 1332, 1164
FAB-MS (neg: m/z, %): 536 ([M—H]+63), 368 (70), 272 (100) [0479]
Melting point: 124-125° C. PHARMACOLOGICAL TEST EXAMPLE 1 [0480]

Measurement of ACC Inhibition Activity

1. Purification of ACC [0481]
After 2 days of fasting, a male SD rat of 12 weeks of age was allowed to feed on a high sucrose feed (67% sucrose, 17.1% casein, 9.8% cellulose, 5% sodium chloride, 0.1% choline chloride and 1% vitamins) for 2 days and then subjected to decapitation and bloodletting under ether anesthesia to quickly take out the liver. The thus obtained liver was sliced in an ice-cooled buffer A (225 mM mannitol, 75 mM sucrose, 10 mM Tris/HCl (pH 7.5), 0.05 mM EDTA-2Na, 5 mM potassium citrate, 2.5 mM MnCl[0482] ₂, 10 mg/l aprotinin, 10 mg/l leupeptin and 10 mg/l antitrypsin) and then, after removal of moisture, adjusted to 5 ml/g by adding the buffer A and homogenized for 4 minutes using Polytron homogenizer. This was centrifuged for 10 minutes at 1,000 g and then the resulting supernatant was subjected to 10 minutes of high speed centrifugation at 17,000 g.
Ammonium sulfate was added to the thus obtained supernatant to a final concentration of 35%, and the mixture was stirred for 45 minutes and then subjected to 10 minutes of high speed centrifugation at 17,000 g. The thus obtained precipitate was mixed with 100 ml of a buffer B (100 mM Tris/HCl (pH 7.5), 0.5 M NaCl, 1 mM EDTA-2Na, 0.1 mM DTT, 10% glycerol, 10 mg/l aprotinin, 10 mg/l leupeptin and 10 mg/l antitrypsin) and subjected to 20 minutes of ultracentrifugation at 40,000, and the resulting supernatant was dialyzed overnight against 150 volumes of a buffer C (100 mM Tris/HCl (pH 7.5), 0.5 M NaCl, 1 mM EDTA-2Na, 0.1 mM DTT and 10% glycerol) and then filtered through a 5 μm filter. The filtrate was applied to a biotin affinity column, washed with the buffer B and then eluted with the buffer B supplemented with 5 mM biotin. [0483]
2. Measurement of ACC Inhibition Activity [0484]
Each of the compounds produced in the Examples was dissolved in DMSO, and the solution was put into a glass vial, mixed with 250 μl of an ACC-containing reagent 1 (40 mM Tris/HCl (pH 7.5), 40 mM MgCl[0485] ₂, 40 mM sodium citrate, 2 mM DTT and 100 μg/ml fatty acid-free BSA),incubated at 37° C. for 30 minutes in a thermostatic chamber, cooled with ice, mixed with 250 μl of a reagent 2 (40 mM Tris/HCl (pH 7.5), 2 mM DTT, 8 mM ATP and 0.5 mM acetyl-CoA) containing 74 kBq of NaH¹⁴CO₃, again incubated at 37° C. for 10 minutes in a thermostatic chamber and then mixed with 0.1 ml of 1 N HCl to terminate the reaction. After complete removal of moisture in the glass vial under a reduced pressure, an emulsified scintillator (Cleasol I) was added to the glass vial, and the ¹⁴C radioactivity was measured using a liquid scintillation counter. The inhibition activity of each compound (5.6×10⁻⁶mmol) was calculated based on the following formula.
Inhibition activity ratio (%)=(1−radioactivity when a drug to be tested is added/radioactivity when the drug to be rested is not added)×100
The results are shown in Table 1. [0486]

PHARMACOLOGICAL TEST 2

Measurement of Intracellular Fatty Acid Synthesis Inhibition Activity (FA Biosynthesis Inhibition Activity)

Each of the compounds produced in the Examples was dissolved in DMSO and added to an experimental culture medium (DMEM; 0.05 μg/ml insulin, 0.1 mg/ml glucose and 18.5 kBq/ml [ ¹⁴C]-glucose). The HepG2 cells were adjusted to a density of 0.75×10⁶cells/ml, inoculated into a 12 well plate in an amount of 1 ml/well and cultured overnight at 37° C. in an atmosphere of 5% CO₂(culture medium: DMEM, 4.5 g/ml glucose and 10% FBS), and the resulting cells were washed twice with PBS(−) buffer, mixed with the experimental culture medium in an amount of 0.5 ml/well and then cultured at 37° C. for 3 hours in an atmosphere of 5% CO₂. After the culturing, the cells were washed twice with ice-cooled PBS(−) buffer and peeled off, and lipids were extracted from the resulting cells with a lipid extraction solution (chloroform:methanol=2:1). The extract was mixed with 2.5 ml of ethanol and 0.1 ml of 33% potassium hydroxide and incubated at 70° C. for 1 hour. Lipids were again extracted from the reaction mixture, and the extract was applied to a silica gel thin layer plate. This was developed with a developing solution (hexane:diethyl ether:acetic acid=80:20:1) and then the fatty acid iodine-coloring part was collected to measure its radioactivity using a liquid scintillation counter. The inhibition activity % (3.0×10⁻⁵M) of each compound was calculated. The results are shown in Table 1.

TABLE 1


		ACC inhibition	FA synthesis
Example		activity (%)	inhibition (%)
No.	Compound name	(5.6 × 10⁻⁶M)	(3.0 × 10⁻⁵M)

2	3-benzyloxy-N-[2-(3-benzylobenzamido)	60.7	43.8
	benzenesulfonyl]benzamide
9	N-[2-(3-benzyloxybenzamido)	65.0	86.8
	benzenesulfonyl]decanamide
13	N-[2-[3- (4-t-butylbenzyloxy)benzamido]	79.5	38.1
	benzenesulfonyl]cinnamide
15	N-[2-(3-benzyloxybenzamido)	84.8	30.6
	benzenesulfonyl]linolamide
16	N-[2-(3-benzyloxy-4-nitrobenzamido)	79.9	94.3
	benzenesulfonyl]decanamide
19	N-[2-[3-(4-chlorobenzyloxy)	83.3	90.5
	benzamido]benzenesulfonyl]decanamide
22	N-[2-[3-(4-nitrobenzyloxy)	88.4	95.2
	benzamido]benzenesulfonyl]decanamide
25	N-[2-[3-(4-methoxybenzyloxy)	81.6	92.0
	benzamido]benzenesulfonyl]decanamide
28	N-[2-(3-cyclohexylmethoxybezamido)	89.4	84.6
	benzenesulfonyl]decanamide
30	N-[2-[3-(4-t-butylbenzyloxy)	53.2	87.1
	benzamido]benzenesulfonyl]hexanamide
31	N-[2-[3-(4-t-butylbenzyloxy)	67.6	66.4
	benzamido]benzenesulfonyl]decanamide
33	N-[2-[3-(4-trifluoronmethylbenzyloxy)	52.3	97.5
	benzamido]benzenesulfonyl]hexanamide
34	N-[2-[3-(4-trifluoromethylbenzyloxy)	81.3	87.7
	benzamido]benzenesulfonyl]decanamide
37	N-[2-(3-heptyloxybenzamido)	83.6	64.3
	benzenesulfonyl]decanamide
39	N-[2-(4-phenylethynylbenzamido)	61.3	92.2
	benzenesulfonyl]hexanamide
40	N-[2-(4-phenylethynylbenzamido)	76.0	57.4
	benzenesulfonyl]decanamide
43	trans-N-[2-(4-phenylethynylbenzamido)	54.3	92.3
	benzenesulfonyl]-2,4-hexadienamide

Thus, as has been described in the foregoing, the invention provides a novel acylsulfonamide derivative represented by the general formula (I), which can be used as an ACC activity inhibitor effective for the treatment of visceral fat syndrome that becomes the risk-factor of diseases of adult people such as myocardial infarction, cerebral infarction and diabetes, so that its effects in terms of medical treatment are considerable. [0488]
This application is based on a Japanese patent application No. 9-277943 filed on Sep. 26, 1997 and a Japanese patent application No. 10-270728 filed on Sep. 25, 1998, both incorporated herein by reference. [0489]

Claims

What is claimed is:

1. An acylsulfonamide derivative represented by a general formula 1

wherein

R¹represents a substituted or unsubstituted C₁-C₁₂alkyl group, a substituted or unsubstituted C₂-C₁₂alkenyl group, a substituted or unsubstituted C₂-C₁₂alkynyl group or a substituted or unsubstituted C₁-C₁₂alkoxy group,

R²represents a hydrogen atom, a hydroxyl group, a mercapto group, a substituted or unsubstituted C₁-C₆alkoxy group, a substituted or unsubstituted C₁-C₆alkylthio group, a nitro group, a halogen atom, a trichloromethyl group, a trifluoromethyl group or a cyano group,

R³represents a substituted or unsubstituted C₁-C₂₀alkyl group, a substituted or unsubstituted C₂-C₂₀alkenyl group, a substituted or unsubstituted C₂-C₂₀alkynyl group, a substituted or unsubstituted aromatic hydrocarbon group, a substituted or unsubstituted aromatic heterocyclic group, a substituted amino group, a substituted or unsubstituted C₁-C₂₀alkoxy group, a substituted or unsubstituted C₂-C₂₀alkenyloxy group, a substituted or unsubstituted C₂-C₂₀alkynyloxy group or a group represented by R⁴O— (wherein R⁴represents a substituted or unsubstituted aromatic hydrocarbon group or a substituted or unsubstituted aromatic heterocyclic group),

Y is a group represented by CH═CH—, —N═CH— or —CH═N—, sulfur atom or oxygen atom, and

ring A represents a substituted or unsubstituted aromatic hydrocarbon group, a substituted or unsubstituted aromatic heterocyclic group or a substituted or unsubstituted cyclic alkyl group.

2. An acylsulfonamide derivative according to claim 1, wherein the ring A is an aromatic hydrocarbon group having a substitution position at the 1,2-position, an aromatic heterocyclic group having a substitution position at the 1,2-position or a cyclic alkyl group having a substitution position at the 1,1-position.

3. An acylsulfonamide derivative according to claim 2, wherein R¹is a C₁-C₄alkyl group having a substituted or unsubstituted aromatic hydrocarbon group or a substituted or unsubstituted aromatic heterocyclic group as a substituent, a C₂-C₄alkenyl group having a substituted or unsubstituted aromatic hydrocarbon group or a substituted or unsubstituted aromatic heterocyclic group as a substituent, a C₂-C₄alkynyl group having a substituted or unsubstituted aromatic hydrocarbon group or a substituted or unsubstituted aromatic heterocyclic group as a substituent or a C₁-C₄alkoxy group having a substituted or unsubstituted aromatic hydrocarbon group or a substituted or unsubstituted aromatic heterocyclic group as a substituent.

4. An acylsulfonamide derivative according to claim 2, wherein R¹is an unsubstituted C₅-C₁₂alkyl group, an unsubstituted C₅-C₁₂alkenyl group, an unsubstituted C₅-C₁₂alkynyl group or an unsubstituted C₅-C₁₂alkoxy group.

5. A medicament which comprises any one of the acylsulfonamide derivatives of claims 1 to 4, or a pharmacologically acceptable salt thereof, as an active ingredient.