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US20010003938A1 - Knife holder for a microtome - Google Patents

Knife holder for a microtome Download PDF

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Publication number
US20010003938A1
US20010003938A1 US09/770,958 US77095801A US2001003938A1 US 20010003938 A1 US20010003938 A1 US 20010003938A1 US 77095801 A US77095801 A US 77095801A US 2001003938 A1 US2001003938 A1 US 2001003938A1
Authority
US
United States
Prior art keywords
knife
plate
cutting
microtome
knife holder
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US09/770,958
Other languages
English (en)
Inventor
Hans Heid
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Microm International GmbH
Original Assignee
Microm International GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Microm International GmbH filed Critical Microm International GmbH
Assigned to MICROM INTERNATIONAL GMBH reassignment MICROM INTERNATIONAL GMBH ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: HEID, HANS
Publication of US20010003938A1 publication Critical patent/US20010003938A1/en
Priority to US11/446,237 priority Critical patent/US7861632B2/en
Abandoned legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/02—Devices for withdrawing samples
    • G01N1/04—Devices for withdrawing samples in the solid state, e.g. by cutting
    • G01N1/06—Devices for withdrawing samples in the solid state, e.g. by cutting providing a thin slice, e.g. microtome
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/02—Devices for withdrawing samples
    • G01N1/04—Devices for withdrawing samples in the solid state, e.g. by cutting
    • G01N1/06—Devices for withdrawing samples in the solid state, e.g. by cutting providing a thin slice, e.g. microtome
    • G01N2001/061—Blade details
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T83/00—Cutting
    • Y10T83/606—Interrelated tool actuating means and guard means
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T83/00—Cutting
    • Y10T83/647—With means to convey work relative to tool station
    • Y10T83/6492—Plural passes of diminishing work piece through tool station
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T83/00—Cutting
    • Y10T83/647—With means to convey work relative to tool station
    • Y10T83/6492—Plural passes of diminishing work piece through tool station
    • Y10T83/6499—Work rectilinearly reciprocated through tool station
    • Y10T83/6508—With means to cause movement of work transversely toward plane of cut
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T83/00—Cutting
    • Y10T83/869—Means to drive or to guide tool
    • Y10T83/872—With guard means
    • Y10T83/8722—Static
    • Y10T83/8723—Adjustable
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T83/00—Cutting
    • Y10T83/929—Tool or tool with support

Definitions

  • Microtomes are used for the production of thin sections of various specimens from medicine, biology, botany, and the materials research and quality control of technical materials, principally plastics.
  • the production of these thin sections takes place with knives of various shapes and properties.
  • Steel knives of selected tool steels are known, and are produced with various kinds of grinding.
  • so-called disposable blades are widely used; for these, a distinction is principally made between so-called wide band blades and narrow band blades, which are replaced by new ones when their service life is exceeded.
  • glass knives and diamond knives are used for special purposes.
  • the knife carriers and knife holders have as their main purpose to stably clamp the respective cutting tool, in order to attain the result of cutting in the form of a thin section of, for example, 3 ⁇ .
  • most knife carriers and knife holders have devices for free angular adjustment between the knife edge and the specimen.
  • Further features of typical knife carriers and knife holders are height adjustment devices for the knife to be clamped, clamp devices for fixing the knife carrier and knife holder on a microtome baseplate or a microtome base frame, and also, in the case of knife carriers and knife holders for cryostatic microtomes, so-called section path devices. Knife carriers and knife holders are denoted hereinafter, for simplification, simply as knife holders.
  • Finger guards are therefore frequently provided, and have to be brought into their functional position, in which they cover the knife, in each working pause and in each preliminary operation of clamping the specimen in the specimen holder, or when adjusting the knife.
  • the finger guard is arranged pivotably on the knife holder for this purpose.
  • Other finger protection devices are not connected to the knife holder and can be set freely on the knife. In such cases they are frequently held in their position by means of weak magnets, or are positioned by pins.
  • other finger protection devices consist of sideways displaceable rods or guard plates, which can be displaced so that they cover the middle cutting region of the knife edge during work pauses.
  • the said finger protection devices all have the disadvantage that they offer no protection during operation, that is, when a series of sections are cut on the microtome.
  • Corresponding finger protection devices are described, for example, in U.S. Pat. No. 5,099,735 and in GB Patent 2,238,973.
  • a knife holder is described in U.S. Pat. No. 4,378,719 with covering elements for the cutting edge of the knife which are stationary relative to the knife; the covering elements only incompletely cover the blade, however.
  • a knife holder with a section straightener, which likewise partially covers the blade, is described in U.S. Pat. No. 5,040,470.
  • Microtomes with knife holders are respectively described in U.S. Pat. No. 1,925,181 and U.S. Pat. No. 5,161,446, in which the abovementioned disadvantages are avoided.
  • the finger protection devices described there respectively have a cover plate for the knife edge, pivotably arranged on the base body of the knife holder, on the specimen side of the knife. When the specimen holder and the knife come close together, this cover plate is pivoted by means of a driver cam out of its functional position in which it covers the cutting edge of the knife, and thus first releases the cutting edge of the knife directly before the section removal.
  • the invention therefore has as its object to provide a knife holder with a guard against cutting injuries which is also effective during the performance of cutting operations and section removal.
  • a knife holder for microtomes having a cutting plane comprising a knife having a cutting edge, and a blade guard comprising a plate, wherein the plate is arranged on a side of the knife remote from a specimen side and spaced apart from the cutting plane of the side of the cutting edge of the knife.
  • the knife holder according to the invention has a blade guard constituted as a plate.
  • the plate is then arranged, on the side of the knife remote from the specimen side, spaced apart from the cutting plane of the knife to be received in the knife holder or of the blade to be received in the knife holder, and to the side of the cutting edge.
  • Such a constitution of the blade guard does not need to be removed for the removal of sections. It is thus fully effective during the removal of sections, and can extend over the whole length of the knife or over the whole length of the knife or blade usually exposed for section removal.
  • the plate is preferably arranged parallel to the knife surface, spaced from the cutting plane.
  • the spacing between the cutting plane and the plate is then preferably chosen to be as large as the maximum section thickness which can be set on the microtome. However, the spacing should be at most 2 mm.
  • the plate preferably consists of a transparent material, for example PMMA, for good observability of section production and a judgment of the removed sections.
  • a gap between the knife edge and the plate is unavoidable, so as to ensure the free space required for a successful section production and section removal.
  • the width of this gap is however to be at most 2.5 mm.
  • the plate is arranged pivotably or displaceably on the base member of the knife holder. It is thereby ensured that the blade guard can be brought out of its functional position into a position in which the free access to the specimen is ensured which is necessary for adjustment operations on the specimen. So that finger protection is also ensured in this position, a known finger guard, which can be removed from the cutting edge during the cutting operation, is also to be provided.
  • the pivoting or displacement mechanism for the plate is coupled to a switch or microswitch.
  • This switch can in turn be coupled electrically to a brake or arresting device for the knife slide or the specimen slide of the microtome, such that movement of the knife slide or of the specimen slide is prevented when the plate is pivoted or displaced out of its functional position covering the cutting edge of the knife. An unintentional operation of the knife slide during adjustment operations on the microtome is thereby avoided.
  • the switch can be arranged in the circuit of the motor for the cutting drive.
  • the load circuit of the drive motor is connected such that an operation of the drive motor is only possible when the plate is located in the functional position covering the knife edge of the knife. It is thereby ensured that an erroneous operation of the operating element such as a foot switch, for example, for the motor drive does not lead to an unintentional switching-on of the cutting drive and thereby bring about the danger of an accident.
  • Possible defects of the operating elements or electrical or electronic components can likewise lead to a comparable danger of an accident, since in the case of corresponding faults the cutting drive can switch on in an uncontrolled manner. Interference influences from the exterior can produce a similar effect. The risks brought about by such faults and interference can thus be markedly reduced by the knife holder according to the invention.
  • FIG. 1 shows a perspective view of a knife holder according to the invention
  • FIG. 2 shows a simplified sectional view through the knife holder in FIG. 1;
  • FIGS. 3 a and 3 b show principle sketches of a knife holder according to the invention with pivotable (FIG. 3 a ) or displaceable (FIG. 3 b ) blade guard;
  • FIG. 4 shows a section through the mounting of a pivoting mechanism for the blade guard according to the invention
  • FIG. 5 shows a section through a traversing microtome with a knife holder according to the invention
  • FIGS. 6 a - 6 c show circuits relating to the inclusion of the switch coupled to the pivoting mechanism in the circuit of an arresting device for the microtome slide or the circuit of a motor drive for the microtome slide;
  • FIG. 7 a shows a perspective view of a disk microtome with a knife holder according to the invention.
  • FIG. 7 b shows a sectional view of the disk microtome of FIG. 7 a.
  • the knife holder in FIG. 1 has an essentially conventional construction with, removably mounted on a microtome base, a base member ( 1 ) on which a receiving member ( 2 ) for the cutting knife ( 3 ) is received, rotatable around the cutting edge of the cutting knife ( 3 ) for free angle setting.
  • the free angle set at any given time is fixedly set by means of a clamping mechanism (not shown here) which can be operated by means of a lever ( 6 ).
  • a clamping plate ( 4 ) is provided, with which the knife ( 3 ) is in a known manner clamped firmly between the receiving member ( 2 ) and the clamping plate ( 4 ) by means of a further clamping mechanism operable by means of a lever ( 5 ).
  • the base member ( 2 ) has, on the side toward the specimen and in the middle region, a recess in which the specimen to be sectioned can come into contact with the cutting edge of the knife ( 3 ) and the specimen can be guided over the knife ( 3 ) for section removal.
  • the knife is usually freely accessible precisely in the region of this recess of the receiving member ( 2 ), so that a cutting injury can very easily happen to the operator.
  • a pivotable yoke ( 7 ) is arranged on the clamping plate ( 4 ) and can be pivoted, in the case of mounting and adjusting operations on the microtome or on the specimen, so that the yoke covers the cutting edge of the knife ( 3 ). After the conclusion of the adjustment operations and before entering into section removal, this guard yoke ( 7 ) must however be pivoted back again into a position in which the knife ( 3 ) is accessible to the specimen, since otherwise section removal could not take place.
  • the knife holder in FIG. 1 corresponds to a conventional knife holder.
  • a further blade guard is provided on the base member ( 1 ) of the knife holder.
  • This blade guard consists of two arms ( 9 a , 9 b ) which are pivotably arranged at the end sides of the base member ( 1 ) and which respectively have a holding jaw ( 10 ), with a plate ( 11 ) of transparent material connecting the holding jaws ( 10 ).
  • the plate ( 11 ) preferably consists of PMMA.
  • the plate ( 11 ) together with the two holding jaws ( 10 ) extends over the whole length of the knife holder, in the direction of the cutting edge of the knife to be received.
  • the plate ( 11 ) is arranged, parallel to the cutting plane ( 14 ), on the side of the knife carrier remote from the specimen holder ( 13 ) and the specimen ( 12 ) received on it, and at the same time, is arranged spaced apart from the knife holder on the side of the cutting edge ( 3 a ) of the knife.
  • the plate ( 11 ) thus faces the cutting edge of the knife. It is ensured by this arrangement of the plate ( 11 ) that section removal can take place even with the plate ( 11 ) situated in its operating position in which the plate prevents an unintentional gripping of the knife edge ( 3 a ).
  • the plate ( 11 ) is spaced apart by a gap (d) from the cutting plane ( 14 ).
  • the width of the gap (d) then corresponds to the maximum section thickness which can be set on the microtome.
  • a small gap (b) is provided between the cutting edge ( 3 a ) of the knife and the edge of the plate ( 11 ) toward the knife, with a maximum width chosen such that the joint of a person's finger cannot come into contact with the cutting edge ( 3 a ) of the knife.
  • the width of the gap (b) is at most 2.5 mm.
  • This gap width is at the same time sufficient for the section taken from the specimen ( 12 ) to be able to slide through this gap between the plate ( 11 ) and the back face of the knife ( 3 ) and to remain lying on the freely accessible back face of the knife ( 3 ).
  • the plate ( 11 ), and thus the whole blade guard can be pivoted, by pivoting around the pivot axis of the arms ( 9 a, 9 b ), out of its functional position into an adjustment position in which the specimen is freely accessible for adjustment operations.
  • This pivotability of the plate ( 11 ) is shown schematically in FIG. 3 a, the plate ( 11 ) in the adjustment position being denoted by ( 11 ′).
  • the plate ( 11 ) can be displaced by a linear displacement from its functional position into an adjustment position ( 11 ′′), in which a free access to the specimen ( 12 ) is ensured.
  • FIG. 4 A section through the pivot mounting of the arm ( 9 a ) is shown in FIG. 4.
  • the pivoting movement of the arm ( 9 a ) is connected to a switch, preferably a microswitch ( 15 ), by means of an actuating arm ( 14 ).
  • the microswitch ( 15 ) is constituted here as a normally open contact, that is, the switch ( 15 ) is only closed when the arm ( 9 a ) is situated in the pivoting position defined by the functional position of the plate ( 11 ).
  • the specimen holder ( 13 ) with the specimen ( 12 ) received on it is horizontally, linearly displaceable on a slide ( 16 ) relative to the knife holder with the knife ( 3 ) received on it.
  • An electromagnetically actuatable brake device ( 17 ) is arranged in the microtome base member and can arrest the slide ( 16 ) in its position at any given time.
  • This brake ( 17 ) is electrically connected to the switch ( 15 ) in the pivot joint of the plate ( 11 ) of the knife holder such that the brake ( 17 ) only releases the slide ( 16 ) when the plate ( 11 ) is pivoted into its functional position in which it covers the cutting edge of the knife ( 3 ).
  • a movement of the slide ( 16 ) is locked by the brake ( 17 ), so that an unintentional displacement of the slide during adjustment operations on the specimen ( 12 ) or on the knife ( 3 ) is prevented.
  • FIG. 6 c The circuit, not shown in FIG. 5, by means of which the switch ( 15 ) on the knife holder is connected to the brake ( 17 ) is shown in FIG. 6 c.
  • the switch ( 15 ) is for this purpose connected in the circuit of a current source ( 18 ), in series with the electromagnet which opens the mechanical drive brake.
  • a further switch ( 24 ) on the control panel of the microtome, and an emergency stop switch ( 21 ), which is embodied as a normally closed contact, are provided in series with the electromagnet ( 17 ) which opens the drive brake. Opening one of the switches ( 15 , 21 , 24 ) effects an immediate arrest of the slide ( 16 ).
  • the serial connection with the further switches ( 21 , 24 ) also enables the arrest of the slide ( 16 ) to be effected in the cases in which the blade guard is in its functional position.
  • FIG. 6 a The circuit for the motor current of a motorized cutting drive is shown in FIG. 6 a .
  • the switch ( 15 ) in the pivot joint of the blade guard is arranged in series in the supply circuit of the motor ( 20 ).
  • the switch ( 15 ), together with the start switch ( 19 ) on the control panel of the microtome and the emergency stop switch ( 21 ), is in the coil circuit of a relay ( 22 ).
  • the drive motor for the disk drive ( 20 ) is in the load circuit of the relay ( 22 , 23 ).
  • a substantial protective effect results from the inclusion of the switch ( 15 ) in the circuit of a brake and/or of a motorized cutting drive, since a motor-driven movement of the cutting drive and a danger connected with this is only possible when the blade guard is located in its functional position. In this functional position, however, cutting injuries are precluded, since the cutting edge of the knife is not at all accessible to the operator. The risk of cutting injuries on the microtome knife is thereby considerably reduced.
  • the knife holder according to the invention is shown in connection with a disk microtome.
  • This disk microtome consists of a baseplate ( 30 ) on which a circular disk ( 33 ) for receiving the specimen ( 32 ) is arranged by means of a column ( 31 ).
  • the disk ( 33 ) can be rotated by a motor drive, not shown here.
  • the base portion ( 34 ) of the knife holder, with the knife ( 37 ) received in it, is arranged on the baseplate ( 30 ).
  • the previously described blade guard with the arms ( 35 a, 35 b ) and the plate ( 36 ) connecting the arms is pivotably arranged on the base portion ( 34 ) of the knife holder.

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  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Details Of Cutting Devices (AREA)
US09/770,958 1998-05-29 2001-01-25 Knife holder for a microtome Abandoned US20010003938A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US11/446,237 US7861632B2 (en) 1998-05-29 2006-06-05 Knife holder for a microtome

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19824024.4 1998-05-29
DE19824024A DE19824024B4 (de) 1998-05-29 1998-05-29 Messerhalter für ein Mikrotom
PCT/EP1999/003175 WO1999063322A1 (fr) 1998-05-29 1999-05-10 Porte-lame de microtome

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1999/003175 Continuation WO1999063322A1 (fr) 1998-05-29 1999-05-10 Porte-lame de microtome

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US11/446,237 Continuation US7861632B2 (en) 1998-05-29 2006-06-05 Knife holder for a microtome

Publications (1)

Publication Number Publication Date
US20010003938A1 true US20010003938A1 (en) 2001-06-21

Family

ID=7869277

Family Applications (2)

Application Number Title Priority Date Filing Date
US09/770,958 Abandoned US20010003938A1 (en) 1998-05-29 2001-01-25 Knife holder for a microtome
US11/446,237 Expired - Fee Related US7861632B2 (en) 1998-05-29 2006-06-05 Knife holder for a microtome

Family Applications After (1)

Application Number Title Priority Date Filing Date
US11/446,237 Expired - Fee Related US7861632B2 (en) 1998-05-29 2006-06-05 Knife holder for a microtome

Country Status (6)

Country Link
US (2) US20010003938A1 (fr)
EP (1) EP1080359B1 (fr)
JP (1) JP4280420B2 (fr)
CN (1) CN1135380C (fr)
DE (2) DE19824024B4 (fr)
WO (1) WO1999063322A1 (fr)

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040194604A1 (en) * 2003-04-03 2004-10-07 Siegfried Fischer Knife holder for a cutting knife of a microtome
US20050120854A1 (en) * 2003-12-05 2005-06-09 Jasco Engineering Corporation Thin-film slicer
US20060123800A1 (en) * 2004-11-20 2006-06-15 Rolf Metzner Desinfection device for a cryostat
US20060185490A1 (en) * 2005-02-23 2006-08-24 Mincer Mathew T Microtome blade
US20090235799A1 (en) * 2004-10-25 2009-09-24 Leica Biosystems Nussloch Gmbh Knife Holder For Microtome Blades
US20100043612A1 (en) * 2007-04-20 2010-02-25 Feather Safety Razor Co., Ltd. Replaceable blade for microtome and curl prevention plate
US20110030523A1 (en) * 2009-08-05 2011-02-10 Microm International Gmbh Safety holder for a microtome knife
WO2010130974A3 (fr) * 2009-05-12 2011-03-10 The Institute Of Cancer Research: Royal Cancer Hospital Dispositif de coupe d'échantillon et préparation de matrices de tissu
US20170336299A1 (en) * 2016-05-19 2017-11-23 Herbert Luttenberger Microtome
CN108175308A (zh) * 2018-03-16 2018-06-19 黄劬莲 一种电动果蔬料理机
CN112931054A (zh) * 2021-04-10 2021-06-11 吴超奎 一种杏鲍菇培养基木杆自动制作设备
CN113043344A (zh) * 2021-03-24 2021-06-29 江西樟树成方中药饮片有限公司 一种中药炮制用枳壳切制装置
EP4208321A4 (fr) * 2020-09-03 2024-06-05 Leica Biosystems Nussloch GmbH Microtome

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US9463119B2 (en) * 2007-01-18 2016-10-11 Abigo Medical Ab Wound dressing with a bacterial adsorbing composition and moisture holding system
US8001876B1 (en) 2008-05-14 2011-08-23 SAIC-Frederick, Inc. Block alignment for microtomes
DE202010011369U1 (de) 2009-09-08 2010-11-18 Microm International Gmbh Messerhalter
DE102011121366A1 (de) 2011-12-19 2013-06-20 Microm International Gmbh Mikrotom
DE102012010275A1 (de) * 2012-05-25 2013-11-28 Microm International Gmbh Mikrotom und Verfahren zur Steuerung einer Schutzvorrichtung eines Mikrotoms
DE102015204013B3 (de) * 2015-03-05 2016-04-14 Pfm Medical Ag Vorrichtung zum positionsgenauen Halten eines Messers oder einer Klinge auf dem Schlitten eines Schlittenmikrotoms und Schlittenmikrotom
CN105865833A (zh) * 2016-05-10 2016-08-17 张家港市光学仪器有限公司 一种切片机的刀架
WO2018089488A1 (fr) * 2016-11-08 2018-05-17 Urschel Laboratories, Inc. Ensemble couteau pour machines à trancher et machines équipées de celui-ci
KR20190097530A (ko) * 2018-02-12 2019-08-21 (의) 삼성의료재단 조직 절편기 및 조직 절편기 브레이크 모듈
CN108214576A (zh) * 2018-03-20 2018-06-29 冯胜利 可调节蔬菜料理机
CN108680380B (zh) * 2018-03-30 2020-12-11 嘉兴新博信息科技有限公司 植物检疫用组织切片装置
CN110887685B (zh) * 2018-09-10 2025-08-01 中国科学院自动化研究所 超薄切片机及其刀台
CN109291128B (zh) * 2018-12-06 2020-10-23 深圳市瑞沃德生命科技有限公司 一种刀架及切片机
CN110328712B (zh) * 2019-06-28 2020-06-16 中国科学院自动化研究所 刀刃位置切换方法、装置及包括该装置的超薄切片机
DE102019119514A1 (de) * 2019-07-18 2021-01-21 Leica Biosystems Nussloch Gmbh Mikrotom
US11898945B2 (en) * 2020-09-18 2024-02-13 Sakura Finetek U.S.A., Inc. Microtome blade guard with integrated blade alignment device
CN113524320A (zh) * 2021-07-20 2021-10-22 浙江省金华市科迪仪器设备有限公司 一种用于切片机的刀架

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US20040194604A1 (en) * 2003-04-03 2004-10-07 Siegfried Fischer Knife holder for a cutting knife of a microtome
US20050120854A1 (en) * 2003-12-05 2005-06-09 Jasco Engineering Corporation Thin-film slicer
US20080022831A1 (en) * 2003-12-05 2008-01-31 Jasco Corporation Thin-Film Slicer
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US20170336299A1 (en) * 2016-05-19 2017-11-23 Herbert Luttenberger Microtome
CN108175308A (zh) * 2018-03-16 2018-06-19 黄劬莲 一种电动果蔬料理机
EP4208321A4 (fr) * 2020-09-03 2024-06-05 Leica Biosystems Nussloch GmbH Microtome
CN113043344A (zh) * 2021-03-24 2021-06-29 江西樟树成方中药饮片有限公司 一种中药炮制用枳壳切制装置
CN112931054A (zh) * 2021-04-10 2021-06-11 吴超奎 一种杏鲍菇培养基木杆自动制作设备

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JP2002517715A (ja) 2002-06-18
CN1135380C (zh) 2004-01-21
CN1309765A (zh) 2001-08-22
DE19824024B4 (de) 2006-03-30
DE19824024A1 (de) 1999-12-02
EP1080359A1 (fr) 2001-03-07
JP4280420B2 (ja) 2009-06-17
US7861632B2 (en) 2011-01-04
EP1080359B1 (fr) 2010-11-17
US20060219080A1 (en) 2006-10-05
WO1999063322A1 (fr) 1999-12-09

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