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UA99132C2 - Производные дикарбоновых кислот как агонисты рецепторов s1p1 - Google Patents

Производные дикарбоновых кислот как агонисты рецепторов s1p1

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Publication number
UA99132C2
UA99132C2 UAA200912896A UAA200912896A UA99132C2 UA 99132 C2 UA99132 C2 UA 99132C2 UA A200912896 A UAA200912896 A UA A200912896A UA A200912896 A UAA200912896 A UA A200912896A UA 99132 C2 UA99132 C2 UA 99132C2
Authority
UA
Ukraine
Prior art keywords
dicarboxylic acid
acid derivatives
receptor agonists
compounds
conditions
Prior art date
Application number
UAA200912896A
Other languages
English (en)
Ukrainian (uk)
Inventor
Марк Капе
Никола Левуан
Изабелла Берреби-Бертран
Филипп Робер
Жан-Шарль Шварц
Жан-Мари Леконт
Джайрадж Дилипбхаи Арадхье
Мутхукумаран Натараджан Пиллаи
Бхавеш Моханбхаи Панчал
Джигнеш Кантилал Дживани
Бисваджит Саманта
Ранджан Кумар Пал
Раджаманнар Тхеннати
Original Assignee
Биопроже
Сан Фарма Эдванст Рисёч Компани Лтд
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Биопроже, Сан Фарма Эдванст Рисёч Компани Лтд filed Critical Биопроже
Publication of UA99132C2 publication Critical patent/UA99132C2/ru

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    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
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    • A—HUMAN NECESSITIES
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    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
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    • A61P19/00—Drugs for skeletal disorders
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    • A61P9/08—Vasodilators for multiple indications
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    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Neurology (AREA)
  • Communicable Diseases (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Transplantation (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)

Abstract

Представленное изобретение касается новых соединений формулы (I), обладающих агонистической активность относительно рецепторов сфингозин-1-фосфата (S1P), способов их получения и их применения в качестве иммунодепрессантов.Изобретение касается также фармацевтических композиций, которые содержат упомянутые соединения, и применения таких композиций для лечения и профилактики заболеваний и состояний, опосредствованных иммунной системой, или воспалительных заболеваний и состояний.
UAA200912896A 2007-06-15 2008-06-16 Производные дикарбоновых кислот как агонисты рецепторов s1p1 UA99132C2 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP07290748A EP2014653A1 (en) 2007-06-15 2007-06-15 Novel dicarboxylic acid derivatives as S1P1 receptor agonists

Publications (1)

Publication Number Publication Date
UA99132C2 true UA99132C2 (ru) 2012-07-25

Family

ID=38645817

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200912896A UA99132C2 (ru) 2007-06-15 2008-06-16 Производные дикарбоновых кислот как агонисты рецепторов s1p1

Country Status (17)

Country Link
US (1) US8809539B2 (ru)
EP (2) EP2014653A1 (ru)
JP (1) JP5346016B2 (ru)
KR (1) KR20100040853A (ru)
CN (1) CN101784535A (ru)
BR (1) BRPI0811712A2 (ru)
CA (1) CA2693126A1 (ru)
CO (1) CO6251262A2 (ru)
EA (1) EA018826B1 (ru)
IL (1) IL202741A0 (ru)
MA (1) MA31447B1 (ru)
MX (1) MX2009013733A (ru)
NZ (1) NZ581933A (ru)
TN (1) TN2009000524A1 (ru)
UA (1) UA99132C2 (ru)
WO (1) WO2008152149A1 (ru)
ZA (1) ZA200908851B (ru)

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CN105816453B (zh) 2008-08-27 2021-03-05 艾尼纳制药公司 用于治疗自身免疫性病症和炎性病症的作为s1p1受体激动剂的经取代的三环酸衍生物
WO2010043000A1 (en) * 2008-10-17 2010-04-22 Akaal Pharma Pty Ltd S1p receptors modulators and their use thereof
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CA2789480A1 (en) 2010-03-03 2011-09-09 Arena Pharmaceuticals, Inc. Processes for the preparation of s1p1 receptor modulators and crystalline forms thereof
WO2011133734A1 (en) * 2010-04-23 2011-10-27 Bristol-Myers Squibb Company 4 - (5 - isoxazolyl or 5 - pyrrazolyl -1,2,4- oxadiazol - 3 - yl) -mandelic acid amides as sphingosin- 1 - phosphate 1 rreceptor agonists
US8318783B2 (en) 2010-04-27 2012-11-27 Allergan, Inc. 3-(4-((1H-imidazol-1-yl)methyl)phenyl)-5-aryl-1,2,4-oxadiazole derivatives as sphingosine-1 phosphate receptors modulators
PT2592933T (pt) 2010-07-16 2017-05-23 Gaweco Anderson Inibidores de mif e suas utilizações
CN103124727B (zh) 2010-07-20 2015-03-25 百时美施贵宝公司 取代的3-苯基-1,2,4-噁二唑化合物
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BR112017027656B1 (pt) 2015-06-22 2023-12-05 Arena Pharmaceuticals, Inc. Hábito cristalino de placa livre de sal de l-arginina de ácido (r)-2-(7-(4- ciclopentil-3-(trifluorometil)benzilóxi)- 1,2,3,4-tetra-hidrociclo-penta[b]indol-3- il)acético, composição farmacêutica que o compreende, seus usos e método de preparação do mesmo
WO2018119080A1 (en) * 2016-12-21 2018-06-28 Cornell University Compositions and methods for treating hepatic disorders
CA3053418A1 (en) 2017-02-16 2018-08-23 Arena Pharmaceuticals, Inc. Compounds and methods for treatment of primary biliary cholangitis
JP2020507610A (ja) 2017-02-16 2020-03-12 アリーナ ファーマシューティカルズ， インコーポレイテッド 腸管外症状を伴う炎症性腸疾患の治療のための化合物および方法
CN107827837B (zh) * 2017-11-21 2021-09-24 苏州朗科生物技术股份有限公司 鞘氨醇-1-磷酸受体调节剂化合物及其制备方法与应用
BR112020015567A2 (pt) * 2018-02-02 2021-02-02 Kyoto University medicamento para prevenir ou tratar doença oftálmica associada com neovascularização intraocular e/ou permeabilidade vascular intraocular realçadas
BR112020024762A2 (pt) 2018-06-06 2021-03-23 Arena Pharmaceuticals, Inc. métodos de tratamento de condições relacionadas ao receptor s1p1
CN119751336A (zh) 2018-09-06 2025-04-04 艾尼纳制药公司 可用于治疗自身免疫性病症和炎性病症的化合物
CN111803636B (zh) * 2020-07-22 2022-08-30 四川大学 1-磷酸鞘氨醇受体1作为microRNA-9调控血管生成的药物靶点的应用
TWI825672B (zh) * 2021-04-14 2023-12-11 南韓商Ｌｇ化學股份有限公司 製備用於合成神經鞘胺醇－１－磷酸酯受體促效劑的中間體之方法
RU2765464C1 (ru) * 2021-05-20 2022-01-31 Федеральное государственное бюджетное учреждение науки Институт органической химии им. Н.Д. Зеленского Российской академии наук (ИОХ РАН) Способ получения эфиров пиперидин-4,4-дикарбоновых кислот
JP7464075B2 (ja) 2022-04-20 2024-04-09 株式会社大林組 プレストレス構造及びそれを用いたプレキャストコンクリート部材

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Also Published As

Publication number Publication date
EP2170850B1 (en) 2014-09-24
CN101784535A (zh) 2010-07-21
ZA200908851B (en) 2010-07-28
EP2170850A1 (en) 2010-04-07
WO2008152149A1 (en) 2008-12-18
CO6251262A2 (es) 2011-02-21
JP5346016B2 (ja) 2013-11-20
US8809539B2 (en) 2014-08-19
IL202741A0 (en) 2010-06-30
AU2008263817A1 (en) 2008-12-18
JP2010529977A (ja) 2010-09-02
CA2693126A1 (en) 2008-12-18
MA31447B1 (fr) 2010-06-01
EA018826B1 (ru) 2013-11-29
KR20100040853A (ko) 2010-04-21
EA201000024A1 (ru) 2010-06-30
MX2009013733A (es) 2010-04-22
US20100249187A1 (en) 2010-09-30
TN2009000524A1 (en) 2011-03-31
BRPI0811712A2 (pt) 2014-11-04
EP2014653A1 (en) 2009-01-14
NZ581933A (en) 2012-01-12

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