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UA98473C2 - СОЛИ И КРИСТАЛЛИЧЕСКИЕ ФОРМЫ 2-МЕТИЛ-2-[4-(3-МЕТИЛ-2-ОКСО-8-ХИНОЛИН-3-ИЛ-2,3-ДИГИДРОИМИДАЗО[4,5-с]ХИНОЛИН-1-ИЛ)ФЕНИЛ]ПРОПИОНИТРИЛА - Google Patents

СОЛИ И КРИСТАЛЛИЧЕСКИЕ ФОРМЫ 2-МЕТИЛ-2-[4-(3-МЕТИЛ-2-ОКСО-8-ХИНОЛИН-3-ИЛ-2,3-ДИГИДРОИМИДАЗО[4,5-с]ХИНОЛИН-1-ИЛ)ФЕНИЛ]ПРОПИОНИТРИЛА

Info

Publication number
UA98473C2
UA98473C2 UAA200905006A UAA200905006A UA98473C2 UA 98473 C2 UA98473 C2 UA 98473C2 UA A200905006 A UAA200905006 A UA A200905006A UA A200905006 A UAA200905006 A UA A200905006A UA 98473 C2 UA98473 C2 UA 98473C2
Authority
UA
Ukraine
Prior art keywords
methyl
quinolin
salts
propionitrile
oxo
Prior art date
Application number
UAA200905006A
Other languages
English (en)
Ukrainian (uk)
Inventor
Франк Штовассер
Маркус Бенцігер
Судхакар Девідасрао Гарад
Original Assignee
Новартіс Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39345299&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UA98473(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Новартіс Аг filed Critical Новартіс Аг
Publication of UA98473C2 publication Critical patent/UA98473C2/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/29—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings
    • C07C309/30—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings of six-membered aromatic rings substituted by alkyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Neurosurgery (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

В заявке описаны кристаллические формы 2-метил-2-[4-(3-метил-2-оксо-8-хинолин-3-ил-2,3-дигидроимидазо[4,5-с]хинолин-1-ил)фенил]пропионитрила, его гидратов и сольватов, его солей и гидратов и сольватов его солей, способы их получения, фармацевтические композиции, содержащие эти кристаллические формы, и их применение в диагностических методиках или, преимущественно, для терапевтического лечения теплокровных животных, преимущественно - людей, а также их применение в качестве промежуточного продукта для изготовления фармацевтических препаратов, предназначенных для применения в диагностических методиках или, преимущественно, для терапевтического лечения теплокровных животных, преимущественно - людей.
UAA200905006A 2006-11-20 2007-11-16 СОЛИ И КРИСТАЛЛИЧЕСКИЕ ФОРМЫ 2-МЕТИЛ-2-[4-(3-МЕТИЛ-2-ОКСО-8-ХИНОЛИН-3-ИЛ-2,3-ДИГИДРОИМИДАЗО[4,5-с]ХИНОЛИН-1-ИЛ)ФЕНИЛ]ПРОПИОНИТРИЛА UA98473C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US86648306P 2006-11-20 2006-11-20
PCT/US2007/084893 WO2008064093A2 (en) 2006-11-20 2007-11-16 Salts and crystal forms of 2-methyl-2-[4-(3-methyl-2-oxo-8-quinolin-3-yl-2,3-dihydro-imidazo[4,5-c]quinolin-1-yl)-phenyl]-propionitrile

Publications (1)

Publication Number Publication Date
UA98473C2 true UA98473C2 (ru) 2012-05-25

Family

ID=39345299

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200905006A UA98473C2 (ru) 2006-11-20 2007-11-16 СОЛИ И КРИСТАЛЛИЧЕСКИЕ ФОРМЫ 2-МЕТИЛ-2-[4-(3-МЕТИЛ-2-ОКСО-8-ХИНОЛИН-3-ИЛ-2,3-ДИГИДРОИМИДАЗО[4,5-с]ХИНОЛИН-1-ИЛ)ФЕНИЛ]ПРОПИОНИТРИЛА

Country Status (35)

Country Link
US (2) US8436177B2 (ru)
EP (2) EP2094700B1 (ru)
JP (2) JP5562033B2 (ru)
KR (3) KR20140091718A (ru)
CN (5) CN102993202A (ru)
AR (1) AR064256A1 (ru)
AU (1) AU2007323820B2 (ru)
BR (1) BRPI0719112A2 (ru)
CA (1) CA2669199C (ru)
CL (1) CL2007003316A1 (ru)
CO (1) CO6382134A2 (ru)
CR (1) CR10757A (ru)
DO (1) DOP2009000116A (ru)
EA (1) EA015677B1 (ru)
EC (1) ECSP099340A (ru)
GE (1) GEP20125436B (ru)
GT (1) GT200900133A (ru)
HR (1) HRP20140627T1 (ru)
IL (2) IL198467A (ru)
JO (1) JO2903B1 (ru)
MA (1) MA30967B1 (ru)
MX (1) MX2009005360A (ru)
MY (1) MY150216A (ru)
NI (1) NI200900091A (ru)
NO (1) NO20092227L (ru)
NZ (1) NZ576357A (ru)
PE (2) PE20081780A1 (ru)
PH (1) PH12013502100A1 (ru)
RS (1) RS53335B (ru)
SM (1) SMP200900041B (ru)
TN (1) TN2009000191A1 (ru)
TW (2) TWI417292B (ru)
UA (1) UA98473C2 (ru)
UY (1) UY30728A1 (ru)
WO (1) WO2008064093A2 (ru)

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Publication number Publication date
IL219877A0 (en) 2012-06-28
IL198467A (en) 2014-11-30
CN109970735A (zh) 2019-07-05
JP5562033B2 (ja) 2014-07-30
JP2010510240A (ja) 2010-04-02
BRPI0719112A2 (pt) 2013-12-10
EP2094700A2 (en) 2009-09-02
CR10757A (es) 2009-06-11
AU2007323820A1 (en) 2008-05-29
PE20081780A1 (es) 2009-01-01
HRP20140627T1 (hr) 2014-09-26
US8436177B2 (en) 2013-05-07
AR064256A1 (es) 2009-03-25
RS53335B (sr) 2014-10-31
SMP200900041B (it) 2009-09-07
NZ576357A (en) 2011-01-28
CA2669199A1 (en) 2008-05-29
GT200900133A (es) 2010-05-21
CN102993202A (zh) 2013-03-27
WO2008064093A3 (en) 2008-08-14
EA200900638A1 (ru) 2009-12-30
MA30967B1 (fr) 2009-12-01
TWI417292B (zh) 2013-12-01
PH12013502100A1 (en) 2015-09-21
JO2903B1 (en) 2015-09-15
KR20140091718A (ko) 2014-07-22
EA015677B1 (ru) 2011-10-31
MX2009005360A (es) 2009-06-05
CL2007003316A1 (es) 2008-06-27
WO2008064093A2 (en) 2008-05-29
CO6382134A2 (es) 2012-02-15
JP2013173788A (ja) 2013-09-05
PE20120083A1 (es) 2012-03-01
IL198467A0 (en) 2010-02-17
CN101541793A (zh) 2009-09-23
HK1132739A1 (en) 2010-03-05
TW201402567A (zh) 2014-01-16
MY150216A (en) 2013-12-13
CA2669199C (en) 2015-12-29
UY30728A1 (es) 2008-07-03
EP2364981A1 (en) 2011-09-14
US20130289064A1 (en) 2013-10-31
US20100168153A1 (en) 2010-07-01
CN106045993A (zh) 2016-10-26
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TN2009000191A1 (en) 2010-10-18
SMAP200900041A (it) 2009-07-14
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KR20140129396A (ko) 2014-11-06
CN102336752A (zh) 2012-02-01
ECSP099340A (es) 2009-06-30
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