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UA97837C2 - Соединения хинолина для лечения нарушений, которые реагируют на модуляцию рецептора серотонина 5-ht6 - Google Patents

Соединения хинолина для лечения нарушений, которые реагируют на модуляцию рецептора серотонина 5-ht6

Info

Publication number
UA97837C2
UA97837C2 UAA200910698A UAA200910698A UA97837C2 UA 97837 C2 UA97837 C2 UA 97837C2 UA A200910698 A UAA200910698 A UA A200910698A UA A200910698 A UAA200910698 A UA A200910698A UA 97837 C2 UA97837 C2 UA 97837C2
Authority
UA
Ukraine
Prior art keywords
serotonin
respond
modulation
treating diseases
receptor
Prior art date
Application number
UAA200910698A
Other languages
English (en)
Ukrainian (uk)
Inventor
Шон Кольм ТЕРНЕР
Андреас ХАУПТ
Вильфрид БРАЙЕ
Удо Лангэ
Карла Дрэшэр
Карстэн Виккэ
Лилиане УНГЕР
Марио МЕЦЛЕР
Вольфганг ВЕРНЕТ
Маттиас МАЙРЕР
Original Assignee
Эбботт Гмбх Унд Ко. Кг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эбботт Гмбх Унд Ко. Кг filed Critical Эбботт Гмбх Унд Ко. Кг
Publication of UA97837C2 publication Critical patent/UA97837C2/ru

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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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Abstract

Данное изобретение касается хинолиновых соединений.Соединения имеют ценные терапевтические свойства и особенно пригодны для лечения заболеваний, которые реагируют на модуляцию серотонинового рецептора 5-НТ.Соединения формулы (I), в которых R представляет собой радикал формулы (R), в которой А, с Rпо Rопределены в формуле изобретения и описании, n представляет собой 0, 1 или 2; m представляет собой 0, 1, 2 или 3; R, Rнезависимо выбирают из группы, которая состоит из галогена, CN, С-С-алкила, С-С-галогеналкила, С-С-алкокси, С-С-галогеналкокси, C(O)R, C(O)NRRи NRR; X представляет собой СН, С(О), С, S(O) или S(O); которая находится в 3 или 4 положении хинолинового кольца; Ar представляет собой радикал Ar-Arили Ar-О-Ar, в котором Ar, Arи Ar, каждый независимо, выбирают из группы, которая состоит из арила или
UAA200910698A 2007-03-23 2008-03-20 Соединения хинолина для лечения нарушений, которые реагируют на модуляцию рецептора серотонина 5-ht6 UA97837C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07104806 2007-03-23
PCT/EP2008/053387 WO2008116831A1 (en) 2007-03-23 2008-03-20 Quinoline compounds suitable for treating didorders that respond to modulation of the serotonin 5-ht6 receptor

Publications (1)

Publication Number Publication Date
UA97837C2 true UA97837C2 (ru) 2012-03-26

Family

ID=39620293

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200910698A UA97837C2 (ru) 2007-03-23 2008-03-20 Соединения хинолина для лечения нарушений, которые реагируют на модуляцию рецептора серотонина 5-ht6

Country Status (24)

Country Link
US (1) US8242102B2 (ru)
EP (1) EP2139880B1 (ru)
JP (1) JP5538907B2 (ru)
KR (1) KR20090128426A (ru)
CN (1) CN101679351B (ru)
AR (1) AR068381A1 (ru)
AT (1) ATE524456T1 (ru)
AU (1) AU2008231787A1 (ru)
BR (1) BRPI0809081A2 (ru)
CA (1) CA2681030C (ru)
CO (1) CO6230989A2 (ru)
CR (1) CR11039A (ru)
DO (1) DOP2009000228A (ru)
EC (1) ECSP099651A (ru)
ES (1) ES2373617T3 (ru)
IL (1) IL201105A0 (ru)
MX (1) MX2009010243A (ru)
NZ (1) NZ579735A (ru)
PE (1) PE20091187A1 (ru)
RU (1) RU2009139073A (ru)
TW (1) TW200940524A (ru)
UA (1) UA97837C2 (ru)
UY (1) UY31326A (ru)
WO (1) WO2008116831A1 (ru)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20140120036A1 (en) * 2012-01-06 2014-05-01 Abbvie Inc. Radiolabeled 5-ht6 ligands
US20130343993A1 (en) * 2012-01-06 2013-12-26 Abbvie Inc. Radiolabeled 5-ht6 ligands
AR106515A1 (es) * 2015-10-29 2018-01-24 Bayer Cropscience Ag Sililfenoxiheterociclos trisustituidos y análogos
WO2017157929A1 (en) * 2016-03-14 2017-09-21 AbbVie Deutschland GmbH & Co. KG Quinoline compounds suitable for treating disorders that respond to the modulation of the serotonin 5-ht6 receptor
CN109053524A (zh) * 2018-09-11 2018-12-21 山东谛爱生物技术有限公司 一种N-Boc-3-羟基氮杂环丁烷的制备方法
CN109503449A (zh) * 2018-12-17 2019-03-22 天津药明康德新药开发有限公司 一种3-硝基吖丁啶-1-甲酸叔丁酯的合成方法

Family Cites Families (12)

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Publication number Priority date Publication date Assignee Title
EP1219618A4 (en) * 1999-09-02 2002-09-18 Wakunaga Pharma Co Ltd QUINOLINECARBOXYLIC ACID DERIVATIVE OR ITS SALT
JP2003277416A (ja) 2002-03-22 2003-10-02 Daiyanitorikkusu Kk 糖類を含むアクリルアミド水溶液
ATE398108T1 (de) * 2002-03-27 2008-07-15 Glaxo Group Ltd Chinolinderivate und deren verwendung als 5-ht6 liganden
US20050165006A1 (en) 2002-04-03 2005-07-28 Dae-Yoon Chi Quinoline derivatives, their preparation and pharmaceutical compositions comprising the same
PL374401A1 (en) 2002-06-05 2005-10-17 F.Hoffmann-La Roche Ag 1-sulfonyl-4-aminoalkoxy indole derivatives as 5-ht6-receptor modulators for the treatment of cns-disorders
US7135575B2 (en) * 2003-03-03 2006-11-14 Array Biopharma, Inc. P38 inhibitors and methods of use thereof
US7227023B2 (en) 2003-04-30 2007-06-05 Wyeth Quinoline 3-amino chroman derivatives
GB0321473D0 (en) 2003-09-12 2003-10-15 Glaxo Group Ltd Novel compounds
GB0411421D0 (en) * 2004-05-21 2004-06-23 Glaxo Group Ltd Novel compounds
CA2616473A1 (en) 2005-07-27 2007-03-08 F. Hoffmann-La Roche Ag 4-aryloxy quinoline derivatives as 5-ht6 modulators
GB0519765D0 (en) * 2005-09-28 2005-11-09 Glaxo Group Ltd Novel compounds
ES2389958T3 (es) 2007-03-21 2012-11-05 Glaxo Group Limited Uso de derivados de quinolina en el tratamiento del dolor

Also Published As

Publication number Publication date
IL201105A0 (en) 2010-05-17
ECSP099651A (es) 2009-10-30
EP2139880A1 (en) 2010-01-06
KR20090128426A (ko) 2009-12-15
JP2010521520A (ja) 2010-06-24
UY31326A (es) 2009-11-10
CN101679351B (zh) 2015-01-07
CO6230989A2 (es) 2010-12-20
CA2681030A1 (en) 2008-10-02
PE20091187A1 (es) 2009-09-06
US8242102B2 (en) 2012-08-14
DOP2009000228A (es) 2009-10-15
MX2009010243A (es) 2009-12-14
WO2008116831A1 (en) 2008-10-02
CA2681030C (en) 2015-01-13
AR068381A1 (es) 2009-11-11
ES2373617T3 (es) 2012-02-07
CN101679351A (zh) 2010-03-24
EP2139880B1 (en) 2011-09-14
CR11039A (es) 2010-02-09
TW200940524A (en) 2009-10-01
JP5538907B2 (ja) 2014-07-02
HK1139933A1 (en) 2010-09-30
ATE524456T1 (de) 2011-09-15
RU2009139073A (ru) 2011-04-27
US20110009380A1 (en) 2011-01-13
NZ579735A (en) 2012-02-24
BRPI0809081A2 (pt) 2019-09-24
AU2008231787A1 (en) 2008-10-02

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