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UA97598C2 - Ингибиторы fxа с циклическим амидоксимом или циклическим амидразоном как р4 субъединица, способы их получения и их фармацевтические композиции и производные - Google Patents

Ингибиторы fxа с циклическим амидоксимом или циклическим амидразоном как р4 субъединица, способы их получения и их фармацевтические композиции и производные

Info

Publication number
UA97598C2
UA97598C2 UAA201101142A UAA201101142A UA97598C2 UA 97598 C2 UA97598 C2 UA 97598C2 UA A201101142 A UAA201101142 A UA A201101142A UA A201101142 A UAA201101142 A UA A201101142A UA 97598 C2 UA97598 C2 UA 97598C2
Authority
UA
Ukraine
Prior art keywords
cyclic
pharmaceutical compositions
derivatives
amidoxime
subunit
Prior art date
Application number
UAA201101142A
Other languages
English (en)
Ukrainian (uk)
Inventor
Хо Йоунг СОНГ
Йоунг Лаг ЧО
Дае Йон ЛИ
Хее Сок ПАРК
Сунг Йоон БАЕК
Санг Еун ЧАЕ
Санг Хой ДЗО
Йеон Ок КИМ
Хианг Соок ЛИ
Дзу Хиун ПАРК
Тае Кио ПАРК
Сунг Хо ВОО
Йонг Зу КИМ
Original Assignee
Легокем Байосайенс Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Легокем Байосайенс Лтд. filed Critical Легокем Байосайенс Лтд.
Publication of UA97598C2 publication Critical patent/UA97598C2/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Данное изобретение касается оксазолидиноновых производных с циклической амидоксимной или циклической амидразоновой группой, их фармацевтически приемлемых солей, способов их получения и фармацевтических композиций, которые их содержат. Оксазолидиноновые производные с циклической амидоксимной или циклической амидразоновой группой или их фармацевтически приемлемые соли можно эффективно применять как антикоагулянты для лечения тромбоэмболии и опухолей на основе ингибирования фактора Ха.
UAA201101142A 2008-07-03 2009-06-05 Ингибиторы fxа с циклическим амидоксимом или циклическим амидразоном как р4 субъединица, способы их получения и их фармацевтические композиции и производные UA97598C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020080064178A KR100898361B1 (ko) 2008-07-03 2008-07-03 Ｐ4 위치에 사이클릭 아미독심 또는 사이클릭 아미드라존기를 가지는 ＦＸａ 저해제, 이의 유도체, 제조방법 및이를 함유하는 의약 조성물
PCT/KR2009/003008 WO2010002115A2 (en) 2008-07-03 2009-06-05 Fxa inhibitors with cyclic amidoxime or cyclic amidrazone as p4 subunit, processes for their preparations, and pharmaceutical compositions and derivatives thereof

Publications (1)

Publication Number Publication Date
UA97598C2 true UA97598C2 (ru) 2012-02-27

Family

ID=40862256

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA201101142A UA97598C2 (ru) 2008-07-03 2009-06-05 Ингибиторы fxа с циклическим амидоксимом или циклическим амидразоном как р4 субъединица, способы их получения и их фармацевтические композиции и производные

Country Status (17)

Country Link
US (1) US8178525B2 (ru)
EP (1) EP2307407B1 (ru)
JP (1) JP5325289B2 (ru)
KR (1) KR100898361B1 (ru)
CN (1) CN102083825B (ru)
AU (1) AU2009266631B2 (ru)
BR (1) BRPI0915326B8 (ru)
CA (1) CA2728350C (ru)
CL (1) CL2010001618A1 (ru)
ES (1) ES2566755T3 (ru)
IL (1) IL210384A (ru)
MX (1) MX2010013969A (ru)
MY (1) MY165573A (ru)
NZ (1) NZ590315A (ru)
RU (1) RU2468024C2 (ru)
UA (1) UA97598C2 (ru)
WO (1) WO2010002115A2 (ru)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101023174B1 (ko) * 2008-09-24 2011-03-18 주식회사 레고켐 바이오사이언스 사이클릭 아미독심 또는 사이클릭 아미드라존 기를 가지는 신규한 옥사졸리디논 유도체 및 이를 함유하는 의약 조성물
KR101037052B1 (ko) 2009-07-08 2011-05-26 주식회사 레고켐 바이오사이언스 5-클로로-ｎ-(((5ｓ)-2-옥소-3-(4-(5,6-디하이드로-1,2,4-트리아진-1(4ｈ)-일)페닐)-1,3-옥사졸리딘-5-일)메틸)티오펜-2-카르복사미드 유도체의 제조방법 및 그 제조중간체
KR101037051B1 (ko) 2009-07-08 2011-05-26 주식회사 레고켐 바이오사이언스 (ｓ)-5-클로로-ｎ-((3-(4-(5,6-다이하이드로-4ｈ-1,2,4-옥사다이아진-3-일)페닐)-2-옥소옥사졸리딘-5-일)메틸)싸이오펜-2-카르복사미드 유도체의 제조방법
JP6325978B2 (ja) * 2011-05-06 2018-05-16 エギシュ ヂョヂセルヂャール ザートケルエン ミケデ レースヴェーニタールササーグ リバロキサバンの製法及び該方法において形成される中間体
US8877628B2 (en) 2012-07-12 2014-11-04 Micron Technologies, Inc. Methods of forming nano-scale pores, nano-scale electrical contacts, and memory devices including nano-scale electrical contacts, and related structures and devices
MX376690B (es) * 2014-07-18 2025-03-07 Green Cross Corp Forma cristalina novedosa de metansulfonato de 5-cloro-n-({(5s)-2-oxo-3-[4-(5,6-dihidro-4h-[1,2,4]triazin-1-il)fenil]-1,3-oxazolidin-5-il}metil)tiofen-2-carboxamida y composicion farmaceutica que contiene la misma.
CN114591337A (zh) * 2022-03-31 2022-06-07 武汉工程大学 一种吡唑并[1,2-a][1,2,4]三嗪-3,6-二酮衍生物及其制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19962924A1 (de) * 1999-12-24 2001-07-05 Bayer Ag Substituierte Oxazolidinone und ihre Verwendung
DE10129725A1 (de) * 2001-06-20 2003-01-02 Bayer Ag Kombinationstherapie substituierter Oxazolidinone
DE10342570A1 (de) 2003-09-15 2005-04-14 Bayer Healthcare Ag Verfahren zur Herstellung von 4-(4-Aminophenyl)-3-morpholinon
US20080051578A1 (en) * 2006-08-24 2008-02-28 Georg Dahmann Substituted biaryls, process for their manufacture and use thereof as medicaments
WO2008140220A1 (en) * 2007-05-09 2008-11-20 Legochem Bioscience Ltd. Fxa inhibitors with cyclic amidines as p4 subunit, processes for their preparations, and pharmaceutical compositions and derivatives thereof

Also Published As

Publication number Publication date
CL2010001618A1 (es) 2011-10-28
CN102083825A (zh) 2011-06-01
RU2468024C2 (ru) 2012-11-27
WO2010002115A2 (en) 2010-01-07
BRPI0915326A2 (pt) 2015-08-04
CN102083825B (zh) 2014-07-30
IL210384A0 (en) 2011-03-31
EP2307407B1 (en) 2016-03-16
EP2307407A4 (en) 2011-08-24
WO2010002115A3 (en) 2010-03-11
MX2010013969A (es) 2011-05-02
JP2011526624A (ja) 2011-10-13
US8178525B2 (en) 2012-05-15
RU2011103766A (ru) 2012-08-10
AU2009266631A1 (en) 2010-01-07
IL210384A (en) 2014-09-30
AU2009266631B2 (en) 2012-03-15
MY165573A (en) 2018-04-05
JP5325289B2 (ja) 2013-10-23
ES2566755T3 (es) 2016-04-15
US20110112083A1 (en) 2011-05-12
NZ590315A (en) 2012-11-30
BRPI0915326B1 (pt) 2021-04-06
CA2728350A1 (en) 2010-01-07
CA2728350C (en) 2013-09-24
BRPI0915326B8 (pt) 2021-05-25
EP2307407A2 (en) 2011-04-13
KR100898361B1 (ko) 2009-05-20

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