UA96035C2 - Substituted indoles and a method for the production and use thereof - Google Patents
Substituted indoles and a method for the production and use thereofInfo
- Publication number
- UA96035C2 UA96035C2 UAA200912190A UAA200912190A UA96035C2 UA 96035 C2 UA96035 C2 UA 96035C2 UA A200912190 A UAA200912190 A UA A200912190A UA A200912190 A UAA200912190 A UA A200912190A UA 96035 C2 UA96035 C2 UA 96035C2
- Authority
- UA
- Ukraine
- Prior art keywords
- optionally substituted
- ris
- rand
- hydrogen
- rtogether
- Prior art date
Links
- 150000002475 indoles Chemical class 0.000 title abstract 3
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 125000003107 substituted aryl group Chemical group 0.000 abstract 2
- BCHZICNRHXRCHY-UHFFFAOYSA-N 2h-oxazine Chemical compound N1OC=CC=C1 BCHZICNRHXRCHY-UHFFFAOYSA-N 0.000 abstract 1
- 206010003757 Atypical pneumonia Diseases 0.000 abstract 1
- 208000037319 Hepatitis infectious Diseases 0.000 abstract 1
- 241000700605 Viruses Species 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 206010064097 avian influenza Diseases 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- 230000007812 deficiency Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 208000005252 hepatitis A Diseases 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000003287 optical effect Effects 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 239000008196 pharmacological composition Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 1
- 125000005346 substituted cycloalkyl group Chemical group 0.000 abstract 1
- 125000003396 thiol group Chemical group [H]S* 0.000 abstract 1
- 230000003612 virological effect Effects 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
, (1)The invention relates to novel substituted indoles, to the use thereof in the form of pharmacological composition substances and to use of said composition for producing medicinal preparations used for preventing and treating viral diseases, in particular caused by viruses of infectious hepatitis (HCV, HBV), human immune deficiency (HIV), atypical pneumonia (SARS) and bird flu. The invention proposes novel substituted indoles of general formula (1) or the racemates or the optical isomers or the pharmaceutically acceptable salts and/or hydrates thereof, wherein R, Rand Rindependently of each other are an aminogroup substituent selected for hydrogen, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted aryl or optionally substituted heterocyclyl, or Rand Rtogether with a nitrogen atom, with which they are bound, form through Rand Roptionally substituted azaheterocyclyl or guanidyl; Ris analkyl substituent selected from hydrogen, an optionally substituted mercaptogroup, optionally substituted aminogroup and optionally substituted hydroxyl; Ris lower alkyl, Ris an hydrogen atom or Rtogether with an oxygen atom with which it is linked or Rtogether with a nitrogen atom with which it is linked close, via Rand Ran oxazine cycle; Ris a cyclic system substituent selected for hydrogen, a halogen atom, cyanogroup, optionally substituted aryl or substituted heterocyclyl.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2006117557/04A RU2323210C9 (en) | 2006-05-23 | 2006-05-23 | Substituted esters of 1h-indol-3-carboxylic acid, pharmaceutical composition, method for their preparing and using |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA96035C2 true UA96035C2 (en) | 2011-09-26 |
Family
ID=38916730
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UAA200912190A UA96035C2 (en) | 2006-05-23 | 2007-05-17 | Substituted indoles and a method for the production and use thereof |
Country Status (2)
| Country | Link |
|---|---|
| RU (1) | RU2323210C9 (en) |
| UA (1) | UA96035C2 (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2421219C1 (en) * | 2009-11-19 | 2011-06-20 | Закрытое Акционерное Общество "Мастерклон" | Protein kinase c inhibitors |
| WO2010064958A2 (en) * | 2008-12-01 | 2010-06-10 | Закрытое Акционерное Общество "Мастерклон" | Protein kinase c inhibitors exhibiting an anti-inflammatory, anti-allergic and anti-asthma effect |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1560035A (en) * | 2004-03-12 | 2005-01-05 | 沈阳药科大学 | 5-Hydroxyindole-3-carboxylic acid lipid derivatives |
-
2006
- 2006-05-23 RU RU2006117557/04A patent/RU2323210C9/en not_active IP Right Cessation
-
2007
- 2007-05-17 UA UAA200912190A patent/UA96035C2/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| RU2323210C9 (en) | 2010-03-27 |
| RU2006117557A (en) | 2007-12-20 |
| RU2323210C2 (en) | 2008-04-27 |
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