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UA96474C2 - Anti-sclerostin antibodies - Google Patents

Anti-sclerostin antibodies

Info

Publication number
UA96474C2
UA96474C2 UAA200909553A UAA200909553A UA96474C2 UA 96474 C2 UA96474 C2 UA 96474C2 UA A200909553 A UAA200909553 A UA A200909553A UA A200909553 A UAA200909553 A UA A200909553A UA 96474 C2 UA96474 C2 UA 96474C2
Authority
UA
Ukraine
Prior art keywords
antibodies
bone
sclerostin antibodies
sclerostin
osteoporosis
Prior art date
Application number
UAA200909553A
Other languages
Russian (ru)
Ukrainian (uk)
Inventor
Эндрю Игор Коритко
Дейвид Метью Маквис
Эрик Майкл Смит
Барбара Энн Свенсон
Original Assignee
Эли Лилли Энд Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эли Лилли Энд Компани filed Critical Эли Лилли Энд Компани
Publication of UA96474C2 publication Critical patent/UA96474C2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Humanized and chimeric antibodies are provided that specifically bind human sclerostin and are characterized as having high affinity and strong neutralizing properties. The antibodies of the invention are useful for increasing bone mass, bone mineral density and bone strength and for the treatment of various disorders, e.g., osteoporosis, in human subject.
UAA200909553A 2007-03-20 2008-03-11 Anti-sclerostin antibodies UA96474C2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US89581307P 2007-03-20 2007-03-20

Publications (1)

Publication Number Publication Date
UA96474C2 true UA96474C2 (en) 2011-11-10

Family

ID=39756356

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200909553A UA96474C2 (en) 2007-03-20 2008-03-11 Anti-sclerostin antibodies

Country Status (31)

Country Link
US (3) US7744874B2 (en)
EP (2) EP2131860B1 (en)
JP (2) JP2010524846A (en)
KR (1) KR101123487B1 (en)
CN (1) CN101646457B (en)
AU (1) AU2008229141B2 (en)
BR (1) BRPI0809026A2 (en)
CA (1) CA2682212C (en)
CO (1) CO6230999A2 (en)
CR (1) CR11004A (en)
CY (1) CY1114784T1 (en)
DK (1) DK2131860T3 (en)
DO (1) DOP2009000223A (en)
EA (1) EA018204B1 (en)
EC (1) ECSP099658A (en)
ES (1) ES2446293T3 (en)
HR (1) HRP20140108T1 (en)
IL (1) IL200437A0 (en)
MA (1) MA31308B1 (en)
MX (1) MX2009010051A (en)
MY (1) MY149129A (en)
NZ (1) NZ578870A (en)
PL (1) PL2131860T3 (en)
PT (1) PT2131860E (en)
RS (1) RS53157B (en)
SI (1) SI2131860T1 (en)
SV (1) SV2009003374A (en)
TN (1) TN2009000383A1 (en)
UA (1) UA96474C2 (en)
WO (1) WO2008115732A2 (en)
ZA (1) ZA200906345B (en)

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US20040009535A1 (en) * 1998-11-27 2004-01-15 Celltech R&D, Inc. Compositions and methods for increasing bone mineralization
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US8461155B2 (en) * 2003-09-22 2013-06-11 University Of Connecticut Sclerostin and the inhibition of WNT signaling and bone formation
US7592429B2 (en) 2005-05-03 2009-09-22 Ucb Sa Sclerostin-binding antibody
US8003108B2 (en) 2005-05-03 2011-08-23 Amgen Inc. Sclerostin epitopes
FI3345607T3 (en) 2006-12-29 2022-11-30 Methods of altering bone growth by administration of sost or wise antagonist or agonist
MY149129A (en) * 2007-03-20 2013-07-15 Lilly Co Eli Anti-sclerostin antibodies
CL2008002775A1 (en) * 2007-09-17 2008-11-07 Amgen Inc Use of a sclerostin binding agent to inhibit bone resorption.
TWI489993B (en) 2007-10-12 2015-07-01 Novartis Ag Compositions and methods of use for antibodies against sclerostin
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SMT202000095T1 (en) 2010-05-14 2020-03-13 Amgen Inc High concentration anti-sclerostin antibody formulations
US8834883B2 (en) 2010-06-14 2014-09-16 Vaccinex, Inc. Anti-VEGF antibodies and uses thereof
HRP20251174T1 (en) 2010-11-05 2025-11-21 Novartis Ag METHODS FOR TREATING PSORIATIC ARTHRITIS USING IL-17 ANTAGONISTS
JP5319651B2 (en) * 2010-11-18 2013-10-16 日本電信電話株式会社 Analysis method
MX365235B (en) 2010-11-30 2019-05-28 Chugai Pharmaceutical Co Ltd Antigen-binding molecule capable of binding to plurality of antigen molecules repeatedly.
DK2663579T3 (en) 2011-01-14 2017-07-31 Univ California THERAPEUTIC ANTIBODIES AGAINST ROR-1 PROTEIN AND PROCEDURES FOR USE THEREOF
JP2014509588A (en) 2011-03-01 2014-04-21 アムジエン・インコーポレーテツド Bispecific binding agent
WO2012135035A1 (en) 2011-03-25 2012-10-04 Amgen Inc. Anti - sclerostin antibody crystals and formulations thereof
EP2699261B1 (en) 2011-04-19 2018-07-11 Amgen Inc. Method for treating osteoporosis
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SI2739311T1 (en) 2011-08-04 2018-07-31 Amgen Inc. Method for treating bone gap defects
CN104093739A (en) 2011-10-24 2014-10-08 艾伯维公司 Immunobinders directed against TNF
JP2014533659A (en) 2011-10-24 2014-12-15 アッヴィ・インコーポレイテッド Immunobinder for sclerostin
UY34410A (en) 2011-10-24 2013-05-31 Abbvie Inc BISPECIFIC IMMUNOLIGANTS DIRECTED AGAINST TNF
ES2813524T3 (en) * 2011-12-28 2021-03-24 Amgen Inc Method of treating alveolar bone loss using antisclerostin antibodies
WO2014006100A1 (en) 2012-07-05 2014-01-09 Ucb Pharma S.A. Treatment for bone diseases
US9221904B2 (en) 2012-07-19 2015-12-29 National Cheng Kung University Treatment of osteoarthritis using IL-20 antagonists
US20140065144A1 (en) * 2012-08-30 2014-03-06 National Cheng Kung University Use of il-20 antagonists for promoting bone fracture healing
UY35148A (en) 2012-11-21 2014-05-30 Amgen Inc HETERODIMERIC IMMUNOGLOBULINS
WO2014118705A1 (en) 2013-01-31 2014-08-07 Novartis Ag Methods of treating chronic kidney disease-mineral and bone disorder using sclerostin antagonists
TWI636063B (en) * 2013-03-08 2018-09-21 美國禮來大藥廠 Antibody that binds IL-23
WO2014144817A2 (en) 2013-03-15 2014-09-18 Amgen Inc. Inhibitory polypeptides specific to wnt inhibitors
WO2014155278A2 (en) 2013-03-26 2014-10-02 Novartis Ag Methods of treating autoimmune diseases using il-17 antagonists
WO2015087187A1 (en) 2013-12-10 2015-06-18 Rinat Neuroscience Corp. Anti-sclerostin antibodies
US9763911B2 (en) 2013-12-12 2017-09-19 Mayo Foundation For Medical Education And Research Prostacyclin compositions for regulation of fracture repair and bone formation
AR100270A1 (en) * 2014-05-19 2016-09-21 Lilly Co Eli ANTIBODIES ANG2
MA41101A (en) * 2014-12-03 2017-10-10 Lilly Co Eli AUTOMATIC DRUG INJECTION DEVICE WITH AUDIBLE INDICATION OF INJECTION PROGRESS
MA41142A (en) 2014-12-12 2017-10-17 Amgen Inc ANTI-SCLEROSTINE ANTIBODIES AND THE USE OF THEM TO TREAT BONE CONDITIONS AS PART OF THE TREATMENT PROTOCOL
AR103173A1 (en) 2014-12-22 2017-04-19 Novarits Ag PHARMACEUTICAL PRODUCTS AND STABLE LIQUID COMPOSITIONS OF ANTIBODIES IL-17
EP3240569A4 (en) * 2014-12-30 2018-05-30 Celgene Corporation Anti-cd47 antibodies and uses thereof
KR102584953B1 (en) 2015-03-13 2023-10-04 지앙수 헨그루이 파마슈티컬스 컴퍼니 리미티드 Anti-sclerostin antibodies, antigen-binding fragments thereof and medical uses
MX2018010445A (en) 2016-03-01 2019-10-17 Yissum Res Dev Co Of Hebrew Univ Jerusalem Ltd Antibodies specific to human poliovirus receptor (pvr).
GB201604124D0 (en) 2016-03-10 2016-04-27 Ucb Biopharma Sprl Pharmaceutical formulation
CN110214021A (en) 2016-08-08 2019-09-06 安进公司 Improve the method for connective tissue attachment using anti-hardened proteins antibody
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AU2020212534A1 (en) * 2019-01-22 2021-07-22 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services High affinity monoclonal antibodies targeting glypican-1 and methods of use
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WO2025019728A1 (en) 2023-07-19 2025-01-23 Amgen Inc. Methods of buffer preparation for a therapeutic protein formulation
WO2025081137A1 (en) * 2023-10-12 2025-04-17 The Regents Of The University Of Michigan Bone targeting therapeutics
CN119097708B (en) * 2024-09-04 2025-05-09 中国医学科学院北京协和医院 Application of DKK1 monoclonal antibody in preparation of pharmaceutical composition for treating osteoporosis

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US20040009535A1 (en) 1998-11-27 2004-01-15 Celltech R&D, Inc. Compositions and methods for increasing bone mineralization
US6395511B1 (en) * 1998-11-27 2002-05-28 Darwin Discovery, Ltd. Nucleic acids encoding a novel family of TGF-β binding proteins from humans
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NZ544618A (en) 2003-06-16 2009-02-28 Celltech R & D Inc Antibodies specific for sclerostin and methods for increasing bone mineralization
US20050033029A1 (en) 2003-06-30 2005-02-10 Jin Lu Engineered anti-target immunoglobulin derived proteins, compositions, methods and uses
EP1853630A1 (en) 2004-10-22 2007-11-14 Applied Molecular Evolution Inc. Methods of optimizing antibody variable region binding affinity
US8003108B2 (en) 2005-05-03 2011-08-23 Amgen Inc. Sclerostin epitopes
US7592429B2 (en) * 2005-05-03 2009-09-22 Ucb Sa Sclerostin-binding antibody
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MY149129A (en) * 2007-03-20 2013-07-15 Lilly Co Eli Anti-sclerostin antibodies

Also Published As

Publication number Publication date
ECSP099658A (en) 2009-10-30
CY1114784T1 (en) 2016-12-14
WO2008115732A3 (en) 2008-12-11
DOP2009000223A (en) 2009-10-15
AU2008229141A1 (en) 2008-09-25
NZ578870A (en) 2012-01-12
EA200970874A1 (en) 2010-02-26
IL200437A0 (en) 2010-04-29
EP2131860A2 (en) 2009-12-16
BRPI0809026A2 (en) 2014-09-23
KR101123487B1 (en) 2012-03-23
CA2682212C (en) 2014-05-06
US20090060924A1 (en) 2009-03-05
RS53157B (en) 2014-06-30
US7988970B2 (en) 2011-08-02
US8257704B2 (en) 2012-09-04
MA31308B1 (en) 2010-04-01
US20110250205A1 (en) 2011-10-13
ZA200906345B (en) 2010-11-24
CO6230999A2 (en) 2010-12-20
JP5758933B2 (en) 2015-08-05
ES2446293T3 (en) 2014-03-07
HK1138790A1 (en) 2010-09-03
JP2013151504A (en) 2013-08-08
CR11004A (en) 2009-11-02
DK2131860T3 (en) 2014-01-13
US20100221263A1 (en) 2010-09-02
PT2131860E (en) 2014-03-04
SV2009003374A (en) 2011-01-10
AU2008229141B2 (en) 2013-02-07
WO2008115732A2 (en) 2008-09-25
JP2010524846A (en) 2010-07-22
MX2009010051A (en) 2009-10-12
CN101646457B (en) 2013-05-01
CA2682212A1 (en) 2008-09-25
EA018204B1 (en) 2013-06-28
MY149129A (en) 2013-07-15
PL2131860T3 (en) 2014-05-30
EP2131860B1 (en) 2013-12-18
HRP20140108T1 (en) 2014-02-28
US7744874B2 (en) 2010-06-29
EP2664346A1 (en) 2013-11-20
KR20090114462A (en) 2009-11-03
CN101646457A (en) 2010-02-10
SI2131860T1 (en) 2014-02-28
TN2009000383A1 (en) 2010-12-31

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