UA95966C2 - 5,7-disubstituted[1,3]thiazolo[4,5]pyrimidin-2(3h)-amine derivatives and their use in therapy - Google Patents
5,7-disubstituted[1,3]thiazolo[4,5]pyrimidin-2(3h)-amine derivatives and their use in therapyInfo
- Publication number
- UA95966C2 UA95966C2 UAA200901647A UAA200901647A UA95966C2 UA 95966 C2 UA95966 C2 UA 95966C2 UA A200901647 A UAA200901647 A UA A200901647A UA A200901647 A UAA200901647 A UA A200901647A UA 95966 C2 UA95966 C2 UA 95966C2
- Authority
- UA
- Ukraine
- Prior art keywords
- thiazolo
- therapy
- pyrimidin
- disubstituted
- formula
- Prior art date
Links
- 238000002560 therapeutic procedure Methods 0.000 title abstract 2
- -1 5,7-disubstituted[1,3]thiazolo[4,5]pyrimidin-2(3h)-amine Chemical class 0.000 title 1
- 108090000835 CX3C Chemokine Receptor 1 Proteins 0.000 abstract 1
- 102100039196 CX3C chemokine receptor 1 Human genes 0.000 abstract 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 abstract 1
- 208000016192 Demyelinating disease Diseases 0.000 abstract 1
- 208000019693 Lung disease Diseases 0.000 abstract 1
- 208000002193 Pain Diseases 0.000 abstract 1
- YWBULOYFCXZCGF-UHFFFAOYSA-N [1,3]thiazolo[4,5-d]pyrimidine Chemical class C1=NC=C2SC=NC2=N1 YWBULOYFCXZCGF-UHFFFAOYSA-N 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 230000003143 atherosclerotic effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 208000015122 neurodegenerative disease Diseases 0.000 abstract 1
- 208000030613 peripheral artery disease Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 239000002464 receptor antagonist Substances 0.000 abstract 1
- 229940044551 receptor antagonist Drugs 0.000 abstract 1
- 206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Landscapes
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
There are disclosed novel 5-substituted 7-amino-[l,3]thiazolo[4,5-d]pyrimidine derivatives of formula (I), (I)wherein R, R, R, Rand n are as defined in the specification, and pharmaceutically acceptable salts thereof, together with processes for their preparation, pharmaceutical compositions comprising them and their use in therapy. The compounds of formula (I) are CX3CR1 receptor antagonists and are thereby particularly useful in the treatment or prophylaxis of neurodegenerative disorders, demyelinating disease, cardio- and cerebrovascular atherosclerotic disorders, peripheral artery disease, rheumatoid arthritis, pulmonary diseases such as COPD, asthma or pain.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US82744206P | 2006-09-29 | 2006-09-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA95966C2 true UA95966C2 (en) | 2011-09-26 |
Family
ID=50837433
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UAA200901647A UA95966C2 (en) | 2006-09-29 | 2007-09-27 | 5,7-disubstituted[1,3]thiazolo[4,5]pyrimidin-2(3h)-amine derivatives and their use in therapy |
Country Status (1)
| Country | Link |
|---|---|
| UA (1) | UA95966C2 (en) |
-
2007
- 2007-09-27 UA UAA200901647A patent/UA95966C2/en unknown
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