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UA95630C2 - Лизобактинамиды, способ их получения (варианты) и применение их как антибактериального средства - Google Patents

Лизобактинамиды, способ их получения (варианты) и применение их как антибактериального средства

Info

Publication number
UA95630C2
UA95630C2 UAA200812942A UAA200812942A UA95630C2 UA 95630 C2 UA95630 C2 UA 95630C2 UA A200812942 A UAA200812942 A UA A200812942A UA A200812942 A UAA200812942 A UA A200812942A UA 95630 C2 UA95630 C2 UA 95630C2
Authority
UA
Ukraine
Prior art keywords
processes
preparation
antibacterial agent
lysobactin
amides
Prior art date
Application number
UAA200812942A
Other languages
English (en)
Ukrainian (uk)
Inventor
НУССБАУМ Франц ФОН
Нина Бруннер
Райнер Эндерманн
Йоханнес Кьобберлинг
Жак Раго
Йоахим Тельсер
Йоахим Шумахер
Соня АНЛАУФ
Иоланда Канчо-Гранде
Сузанне Грешат
Ханс-Кристиан Милитцер
Гуидо Шиффер
Original Assignee
Аикурис Гмбх & Ко. Кг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Аикурис Гмбх & Ко. Кг filed Critical Аикурис Гмбх & Ко. Кг
Publication of UA95630C2 publication Critical patent/UA95630C2/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/60—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation occurring through the 4-amino group of 2,4-diamino-butanoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Analytical Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

В заявке описаны лизобактинамиды формулы (I) и способы их получения, а также их применение для приготовления лекарственных средств, предназначенных для лечения и/или профилактики заболеваний, преимущественно бактериальных инфекционных заболеваний.(I)
UAA200812942A 2006-04-13 2007-04-13 Лизобактинамиды, способ их получения (варианты) и применение их как антибактериального средства UA95630C2 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102006018080A DE102006018080A1 (de) 2006-04-13 2006-04-13 Lysobactinamide

Publications (1)

Publication Number Publication Date
UA95630C2 true UA95630C2 (ru) 2011-08-25

Family

ID=38093447

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200812942A UA95630C2 (ru) 2006-04-13 2007-04-13 Лизобактинамиды, способ их получения (варианты) и применение их как антибактериального средства

Country Status (16)

Country Link
US (1) US8076285B2 (ru)
EP (1) EP2007794B1 (ru)
JP (1) JP2009533371A (ru)
KR (1) KR20080110902A (ru)
CN (1) CN101466729A (ru)
AT (1) ATE524488T1 (ru)
AU (1) AU2007237431A1 (ru)
BR (1) BRPI0709507A2 (ru)
CA (1) CA2648164A1 (ru)
DE (1) DE102006018080A1 (ru)
IL (1) IL194353A0 (ru)
MX (1) MX2008013191A (ru)
RU (1) RU2441021C2 (ru)
UA (1) UA95630C2 (ru)
WO (1) WO2007118691A1 (ru)
ZA (1) ZA200809686B (ru)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0919194D0 (en) * 2009-11-02 2009-12-16 Lytix Biopharma As Compounds
ES2395606B1 (es) * 2011-06-29 2014-01-16 Consejo Superior De Investigaciones Científicas (Csic) Proceso químico para la modificación selectiva de péptidos.
CN105985991B (zh) * 2015-02-11 2020-08-18 上海医药工业研究院 一种苯基取代的烷基胺的制备方法和纯化方法
TW201717991A (zh) 2015-08-17 2017-06-01 拜耳動物保健有限公司 用於治療牛乳房炎之溶桿菌素
EP3363452A1 (en) 2017-02-17 2018-08-22 Bayer Animal Health GmbH Combinations of lysobactin and aminogylcosides against diseases caused by gram-positive and gram-negative bacteria in non-human animals
EP3592761B1 (en) * 2017-03-09 2025-05-14 The University of Liverpool New antibacterial products

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1266247C (en) 1985-03-25 1990-02-27 ANTIBIOTIC PREPARED BY LYSOBACTER SP. SC14.067
JPH01132600A (ja) 1987-11-17 1989-05-25 Shionogi & Co Ltd カタノシンａおよびｂならびにその製造法
AU726146B2 (en) * 1996-10-24 2000-11-02 Board Of Trustees Of The University Of Illinois, The Total synthesis of the amino hip analogue of didemnin A
WO2001005814A1 (en) 1999-07-15 2001-01-25 Eli Lilly And Company Pseudomycin n-acyl side-chain analogs
HRP20030027A2 (en) 2000-06-28 2004-02-29 Teva Pharma Carvedilol
DE10320781A1 (de) 2003-05-09 2004-11-25 Bayer Healthcare Ag Acylierte Nonadepsipeptide
US7169756B2 (en) * 2004-04-16 2007-01-30 Mcmaster University Streptogramin antibiotics
DE102004051023A1 (de) 2004-10-20 2006-05-04 Bayer Healthcare Ag Desoxo-Nonadepsipeptide
DE102004051024A1 (de) 2004-10-20 2006-04-27 Bayer Healthcare Ag Heterocyclyl-substituierte Nonadepsipeptide
DE102004051025A1 (de) 2004-10-20 2006-04-27 Bayer Healthcare Ag Substituierte Nonadepsipeptide
DE102004053410A1 (de) * 2004-11-05 2006-05-11 Bayer Healthcare Ag Cyclische Nonadepsipeptidamide
DE102004053407A1 (de) 2004-11-05 2006-05-11 Bayer Healthcare Ag Acylierte Nonadepsipeptide II
DE102006003443A1 (de) 2006-01-25 2007-07-26 Aicuris Gmbh & Co. Kg Asparagin-10-substituierte Nonadepsipeptide

Also Published As

Publication number Publication date
RU2008144660A (ru) 2010-05-20
CN101466729A (zh) 2009-06-24
ZA200809686B (en) 2010-05-26
WO2007118691A1 (de) 2007-10-25
JP2009533371A (ja) 2009-09-17
ATE524488T1 (de) 2011-09-15
DE102006018080A1 (de) 2007-10-18
IL194353A0 (en) 2011-08-01
RU2441021C2 (ru) 2012-01-27
US20090203582A1 (en) 2009-08-13
KR20080110902A (ko) 2008-12-19
EP2007794B1 (de) 2011-09-14
EP2007794A1 (de) 2008-12-31
US8076285B2 (en) 2011-12-13
CA2648164A1 (en) 2007-10-25
AU2007237431A1 (en) 2007-10-25
BRPI0709507A2 (pt) 2011-07-19
MX2008013191A (es) 2009-01-12

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