UA95612C2 - Herbal composition comprising an extract of flowering and fruiting heads of the plant, sphaeranthus indicus for inflammatory disorders - Google Patents
Herbal composition comprising an extract of flowering and fruiting heads of the plant, sphaeranthus indicus for inflammatory disordersInfo
- Publication number
- UA95612C2 UA95612C2 UAA200804923A UAA200804923A UA95612C2 UA 95612 C2 UA95612 C2 UA 95612C2 UA A200804923 A UAA200804923 A UA A200804923A UA A200804923 A UAA200804923 A UA A200804923A UA 95612 C2 UA95612 C2 UA 95612C2
- Authority
- UA
- Ukraine
- Prior art keywords
- relates
- compositions
- extract
- flowering
- plant
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 8
- 244000085223 Sphaeranthus indicus Species 0.000 title abstract 3
- 241000196324 Embryophyta Species 0.000 title abstract 2
- 208000027866 inflammatory disease Diseases 0.000 title abstract 2
- 230000017260 vegetative to reproductive phase transition of meristem Effects 0.000 title abstract 2
- 108010064593 Intercellular Adhesion Molecule-1 Proteins 0.000 abstract 2
- 102000015271 Intercellular Adhesion Molecule-1 Human genes 0.000 abstract 2
- 108060008682 Tumor Necrosis Factor Proteins 0.000 abstract 2
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 abstract 2
- 108010000134 Vascular Cell Adhesion Molecule-1 Proteins 0.000 abstract 2
- 102100023543 Vascular cell adhesion protein 1 Human genes 0.000 abstract 2
- 229940121363 anti-inflammatory agent Drugs 0.000 abstract 2
- 239000002260 anti-inflammatory agent Substances 0.000 abstract 2
- RHDGNLCLDBVESU-UHFFFAOYSA-N but-3-en-4-olide Chemical compound O=C1CC=CO1 RHDGNLCLDBVESU-UHFFFAOYSA-N 0.000 abstract 2
- 229940125904 compound 1 Drugs 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 abstract 1
- XMPDAVDYIOMTLX-UHFFFAOYSA-N 7-hydroxy eudesm-4-en-6,12-olide Natural products C1CC2(C)CCCC(C)=C2C2OC(=O)C(=C)C21O XMPDAVDYIOMTLX-UHFFFAOYSA-N 0.000 abstract 1
- 102000015689 E-Selectin Human genes 0.000 abstract 1
- 108010024212 E-Selectin Proteins 0.000 abstract 1
- 108090001007 Interleukin-8 Proteins 0.000 abstract 1
- 108010063738 Interleukins Proteins 0.000 abstract 1
- 102000015696 Interleukins Human genes 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 230000000975 bioactive effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000003550 marker Substances 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
This invention relates to a novel herbal composition comprising an extract of flowering and fruiting heads of the plant, Sphaeranthus indicus. The said extract of Sphaeranthus indicus contains a compound, 3a-hydroxy-5a,9-dimethyl-3-methylene-3a,4,5,5a,6,7,8,9b-octahydro-3H-naphtho[l,2-b]furan-2-one (7-Hydroxy-4,11(13)-eudesmadien-12,6-olide) (compound 1), as a bioactive marker. The invention also relates to a composition comprising 3a-hydroxy-5a,9-dimethyl-3-methylene-3a,4,5,5a,6,7,8,9b-octahydro-3H-naphtho[l,2-b]furan-2-one (compound 1) as an active ingredient. The invention also relates to methods of manufacture of the said compositions. The invention also relates to methods of administration of the said compositions to a subject in need of treatment for an inflammatory disorder. The invention also relates to tumor necrosis factor-α (TNF-α) and interleukin (TL-1, TL-6, IL-8) inhibitory activity of the said compositions. The invention relates to inhibition of the expression of intercellular adhesion molecule 1 (ICAM-1), vascular-cell adhesion molecule 1 (VCAM-1), and E-Selectin by the said compositions. The said compositions may optionally contain at least one anti- inflammatory agent or can be used in combination with at least one anti- inflammatory agent.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN1226MU2005 | 2005-09-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA95612C2 true UA95612C2 (en) | 2011-08-25 |
Family
ID=40114308
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UAA200804923A UA95612C2 (en) | 2005-09-30 | 2006-09-28 | Herbal composition comprising an extract of flowering and fruiting heads of the plant, sphaeranthus indicus for inflammatory disorders |
Country Status (8)
| Country | Link |
|---|---|
| CN (1) | CN101304756B (en) |
| BR (1) | BRPI0616724A2 (en) |
| DK (1) | DK1931366T3 (en) |
| ES (1) | ES2426174T3 (en) |
| PT (1) | PT1931366E (en) |
| SI (1) | SI1931366T1 (en) |
| UA (1) | UA95612C2 (en) |
| ZA (1) | ZA200803632B (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2010220058B2 (en) * | 2009-02-02 | 2016-02-18 | Laila Nutra Private Limited | Composition from Sphaeranthus indicus and Garcinia mangostana for the control of metabolic syndrome |
| BR112015009179A2 (en) * | 2012-10-23 | 2017-07-04 | Piramal Entpr Ltd | herbal composition |
| CN106467564B (en) * | 2015-08-18 | 2020-03-31 | 中国人民解放军北部战区总医院 | A flos Eriocauli phenolic acid enriched fraction and its application in preparing antitumor drugs |
| CN108865991A (en) * | 2018-08-14 | 2018-11-23 | 广州市番禺区中心医院 | A kind of preparation process of culture medium that simulating diabetes inflammatory microenvironment |
-
2006
- 2006-09-28 DK DK06809434.1T patent/DK1931366T3/en active
- 2006-09-28 ES ES06809434T patent/ES2426174T3/en active Active
- 2006-09-28 PT PT68094341T patent/PT1931366E/en unknown
- 2006-09-28 BR BRPI0616724-1A patent/BRPI0616724A2/en not_active IP Right Cessation
- 2006-09-28 SI SI200631640T patent/SI1931366T1/en unknown
- 2006-09-28 ZA ZA200803632A patent/ZA200803632B/en unknown
- 2006-09-28 CN CN2006800407702A patent/CN101304756B/en not_active Expired - Fee Related
- 2006-09-28 UA UAA200804923A patent/UA95612C2/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN101304756A (en) | 2008-11-12 |
| ES2426174T8 (en) | 2014-01-29 |
| CN101304756B (en) | 2013-03-20 |
| BRPI0616724A2 (en) | 2011-06-28 |
| PT1931366E (en) | 2013-09-04 |
| SI1931366T1 (en) | 2013-10-30 |
| DK1931366T3 (en) | 2013-09-08 |
| ZA200803632B (en) | 2009-11-25 |
| ES2426174T3 (en) | 2013-10-21 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| WO2006044860A3 (en) | Thiadiazole compounds and methods of use | |
| WO2002014311A3 (en) | Urea compounds and methods of uses | |
| WO2005077344A3 (en) | Hydantoin derivatives as inhibitors of cellular necrosis | |
| WO2003044021A3 (en) | Substituted indolizine-like compounds and methods of use | |
| BRPI0411825B8 (en) | 5-element heterocycle-based p38 kinase inhibitors, their preparation processes and their uses, as well as pharmaceutical composition | |
| WO2008089034A3 (en) | Cytokine inhibitors | |
| WO2005004818A3 (en) | Heterocyclic compounds and their use as anticancer agents | |
| WO2007084391A3 (en) | Thiazole compounds as protein kinase b ( pkb) inhibitors | |
| WO2004046345A3 (en) | Use of hmgb fragments as anti-inflammatory agents | |
| WO2009025763A3 (en) | Therapeutic compositions for treatment of inflammation of ocular and adnexal tissues | |
| WO2006096434A3 (en) | Pharmaceutical compositions for the treatment and/or prevention of anxiety disorders | |
| WO2010042489A3 (en) | Aminoquinoline derived heat shock protein 90 inhibitors, methods of preparing same, and methods for their use | |
| WO2007005668A3 (en) | Bis-aryl kinase inhibitors and their use in the treatment of inflammation, angiogenesis and cancer | |
| WO2007022225A3 (en) | Cyclic nitro compounds, pharmaceutical compositions thereof and uses thereof | |
| WO2012033634A3 (en) | Topical skin care formulations comprising plant extracts | |
| WO2007036900A3 (en) | Herbal composition for inflammatory disorders | |
| WO2007149865A3 (en) | Methods and compositions related to inhibition of ceramide synthesis | |
| WO2009039218A3 (en) | Compositions and methods for treating inflammation and inflammation-related disorders by plectranthus amboinicus extracts | |
| WO2009066060A3 (en) | 4-substituted-6-isopropyl-benzene-1,3-diol compounds and their use | |
| SI1492773T1 (en) | 4-(heterocyclyl)-benzenesulfoximine compounds for the treatment of inflammation | |
| WO2005121778A3 (en) | Methods for identification, and compounds useful for the treatment of degenerative & inflammatory diseases | |
| WO2006026747A3 (en) | Diphenylethylene compounds and uses thereof | |
| UA95612C2 (en) | Herbal composition comprising an extract of flowering and fruiting heads of the plant, sphaeranthus indicus for inflammatory disorders | |
| WO2010042500A3 (en) | Heat shock protein 90 inhibitors, methods of preparing same, and methods for their use | |
| WO2003013564A3 (en) | An herbal composition for the treatment and remedy of bronchial respiratory difficulties |