UA92169C2 - Fused heterocyclic compounds, process for the preparation thereof, pharmaceutical composition, crf receptor antagonist, tretment method and use of crf receptor antagonist - Google Patents
Fused heterocyclic compounds, process for the preparation thereof, pharmaceutical composition, crf receptor antagonist, tretment method and use of crf receptor antagonistInfo
- Publication number
- UA92169C2 UA92169C2 UAA200711851A UAA200711851A UA92169C2 UA 92169 C2 UA92169 C2 UA 92169C2 UA A200711851 A UAA200711851 A UA A200711851A UA A200711851 A UAA200711851 A UA A200711851A UA 92169 C2 UA92169 C2 UA 92169C2
- Authority
- UA
- Ukraine
- Prior art keywords
- optionally substituted
- receptor antagonist
- crf receptor
- preparation
- pharmaceutical composition
- Prior art date
Links
- 239000002769 corticotropin releasing factor antagonist Substances 0.000 title abstract 3
- 238000000034 method Methods 0.000 title 2
- 150000002391 heterocyclic compounds Chemical class 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical class N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 4
- 125000002252 acyl group Chemical group 0.000 abstract 3
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract 3
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 150000002431 hydrogen Chemical group 0.000 abstract 2
- 229910052757 nitrogen Chemical class 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 239000001301 oxygen Substances 0.000 abstract 2
- 229910052717 sulfur Inorganic materials 0.000 abstract 2
- 239000011593 sulfur Chemical group 0.000 abstract 2
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 150000001721 carbon Chemical class 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
There is provided a CRF receptor antagonist comprising a compound of the formula (I): wherein R1 is an optionally substituted hydrocarbyl, an optionally substituted C-linked heterocyclic group, an optionally substituted N-linked heteroaryl group, a cyano or an acyl; R2 is an optionally substituted cyclic hydrocarbyl or an optionally substituted heterocyclic group; X is oxygen, sulfur or -NR3-(wherein R3 is a hydrogen, an optionally substituted hydrocarbyl or an acyl); Y1, Y2 and Y3 are each an optionally substituted carbon or a nitrogen, provided that one or less of Y1, Y2 and Y3 is nitrogen; and Z is a bond, -CO-, oxygen, sulfur, -SO-, -SO-, -NR4-, -NR4-alk-, -CONR4- or -NR4CO- (wherein alk is an optionally substituted C3-4 alkylene and R4 is a hydrogen, an optionally substituted hydrocarbyl or an acyl); or a salt thereof or a prodrug thereof.(I)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US67511305P | 2005-04-27 | 2005-04-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA92169C2 true UA92169C2 (en) | 2010-10-11 |
Family
ID=39334842
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UAA200711851A UA92169C2 (en) | 2005-04-27 | 2006-04-26 | Fused heterocyclic compounds, process for the preparation thereof, pharmaceutical composition, crf receptor antagonist, tretment method and use of crf receptor antagonist |
Country Status (3)
| Country | Link |
|---|---|
| CN (1) | CN101166729B (en) |
| UA (1) | UA92169C2 (en) |
| ZA (1) | ZA200708844B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102153538B (en) * | 2010-02-11 | 2013-12-11 | 山东轩竹医药科技有限公司 | Benzocyclodirivative |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6124463A (en) * | 1998-07-02 | 2000-09-26 | Dupont Pharmaceuticals | Benzimidazoles as corticotropin release factor antagonists |
| US6365589B1 (en) * | 1998-07-02 | 2002-04-02 | Bristol-Myers Squibb Pharma Company | Imidazo-pyridines, -pyridazines, and -triazines as corticotropin releasing factor antagonists |
-
2006
- 2006-04-26 UA UAA200711851A patent/UA92169C2/en unknown
- 2006-04-26 CN CN2006800147137A patent/CN101166729B/en not_active Expired - Fee Related
-
2008
- 2008-04-26 ZA ZA200708844A patent/ZA200708844B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN101166729B (en) | 2011-08-31 |
| ZA200708844B (en) | 2009-08-26 |
| CN101166729A (en) | 2008-04-23 |
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