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UA90483C2 - Похідні n-(1н-індоліл)-1н-індол-2-карбоксамідів, їх отримання і їх застосування в терапії - Google Patents

Похідні n-(1н-індоліл)-1н-індол-2-карбоксамідів, їх отримання і їх застосування в терапії

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Publication number
UA90483C2
UA90483C2 UAA200702276A UAA200702276A UA90483C2 UA 90483 C2 UA90483 C2 UA 90483C2 UA A200702276 A UAA200702276 A UA A200702276A UA A200702276 A UAA200702276 A UA A200702276A UA 90483 C2 UA90483 C2 UA 90483C2
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Prior art keywords
alkyl
group
aryl group
cycloalkyl
represent
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UAA200702276A
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English (en)
Russian (ru)
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Лоран Дюбуа
Яннік Еванно
Люк Евен
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Санофі-Авентіс
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/30Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404Indoles, e.g. pindolol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/10Drugs for disorders of the urinary system of the bladder
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/04Antipruritics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
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    • A61P27/02Ophthalmic agents
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    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P31/12Antivirals
    • A61P31/20Antivirals for DNA viruses
    • A61P31/22Antivirals for DNA viruses for herpes viruses
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  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Винахід стосується сполук формули (І), в якій X1, Х2, Х3, Х4, Z1, Z2, Z3, Z4 і Z5 означають незалежно один від одного атом водню або галогену або С1-С6-алкільну, С3-C7-циклоалкільну, С1-С6-фторалкільну, С1-С6-алкокси, С1-С6-фторалкокси, ціано, C(O)NR1R2, нітро, NR1R2, С1-С6-тіоалкільну, -S(O)-С1-С6-алкільну, -S(O)2-С1-С6-алкільну, SO2NR1R2, NR3СОR4, NR3SO2R5 або арильну групу; Х5 означає атом водню або галогену або С1-С6-алкільну, С1-С6-фторалкільну групу; R означає 4-, 5-, 6- або 7-індолільну групу, необов'язково заміщену, Y означає атом водню або С1-С6-алкільну групу; n дорівнює 0, 1, 2 або 3; R1 і R2 означають незалежно один від одного атом водню або С1-С6-алкільну, С3-С7-циклоалкільну, С3-С7-циклоалкіл-С1-С3-алкільну або арильну групу; або R1 і R2 утворюють разом з атомом азоту, з яким вони зв'язані, азетидинову, піролідинову, піперидинову, азепінову, морфолінову, тіоморфолінову, піперазинову, гомопіперазинову групу, причому вказана група необов'язково заміщена С1-С6-алкільною, С3-С7-циклоалкільною, С3-С7-циклоалкіл-С1-С3-алкільною або арильною групою; R3 і R4 означають незалежно один від одного атом водню або С1-С6-алкільну або арильну групу; R5 означає С1-С6-алкільну або арильну групу; у формі основи або солі приєднання кислоти, а також у формі гідрату або сольвату. Спосіб отримання і застосування в терапії.
UAA200702276A 2004-08-05 2005-02-08 Похідні n-(1н-індоліл)-1н-індол-2-карбоксамідів, їх отримання і їх застосування в терапії UA90483C2 (uk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0408652A FR2874015B1 (fr) 2004-08-05 2004-08-05 Derives de n-(1h-indolyl)-1h-indole-2-carboxamides, leur preparation et leur application en therapeutique
PCT/FR2005/002014 WO2006024776A1 (fr) 2004-08-05 2005-08-02 Derives de n-(1 h-indolyl)-i h-ind0le-2-carb0xamides, leur preparation et leur application en therapeutique

Publications (1)

Publication Number Publication Date
UA90483C2 true UA90483C2 (uk) 2010-05-11

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ID=34950701

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200702276A UA90483C2 (uk) 2004-08-05 2005-02-08 Похідні n-(1н-індоліл)-1н-індол-2-карбоксамідів, їх отримання і їх застосування в терапії

Country Status (37)

Country Link
US (3) US7384969B2 (uk)
EP (1) EP1776340B1 (uk)
JP (1) JP5100381B2 (uk)
KR (1) KR101215162B1 (uk)
CN (1) CN101010297B (uk)
AR (1) AR050283A1 (uk)
AT (1) ATE416160T1 (uk)
AU (1) AU2005279085B2 (uk)
BR (1) BRPI0513087A (uk)
CA (1) CA2576727C (uk)
CR (1) CR8889A (uk)
CY (1) CY1108816T1 (uk)
DE (1) DE602005011450D1 (uk)
DK (1) DK1776340T3 (uk)
EA (1) EA011714B1 (uk)
EC (1) ECSP077215A (uk)
ES (1) ES2318542T3 (uk)
FR (1) FR2874015B1 (uk)
HR (1) HRP20090101T3 (uk)
IL (1) IL180911A (uk)
MA (1) MA28845B1 (uk)
ME (1) ME01663B (uk)
MX (1) MX2007001436A (uk)
MY (1) MY139286A (uk)
NO (1) NO340060B1 (uk)
NZ (1) NZ552924A (uk)
PE (1) PE20060557A1 (uk)
PL (1) PL1776340T3 (uk)
PT (1) PT1776340E (uk)
RS (1) RS50853B (uk)
SI (1) SI1776340T1 (uk)
TN (1) TNSN07041A1 (uk)
TW (1) TWI360538B (uk)
UA (1) UA90483C2 (uk)
UY (1) UY29046A1 (uk)
WO (1) WO2006024776A1 (uk)
ZA (1) ZA200700999B (uk)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2874015B1 (fr) * 2004-08-05 2006-09-15 Sanofi Synthelabo Derives de n-(1h-indolyl)-1h-indole-2-carboxamides, leur preparation et leur application en therapeutique
FR2880625B1 (fr) 2005-01-07 2007-03-09 Sanofi Aventis Sa Derives de n-(heteroaryl)-1h-indole-2-carboxamides, leur preparation et leur application en therapeutique
FR2888847B1 (fr) * 2005-07-22 2007-08-31 Sanofi Aventis Sa Derives de n-(heteriaryl)-1-heteorarylalkyl-1h-indole-2- carboxamides, leur preparation et application en therapeutique
PE20080145A1 (es) 2006-03-21 2008-02-11 Janssen Pharmaceutica Nv Tetrahidro-pirimidoazepinas como moduladores de trpv1
FR2910473B1 (fr) 2006-12-26 2009-02-13 Sanofi Aventis Sa Derives de n-(amino-heteroaryl)-1h-pyrrolopyridine-2- carboxamides, leur preparation et leur application en therapeutique.
FR2911604B1 (fr) 2007-01-19 2009-04-17 Sanofi Aventis Sa Derives de n-(heteroaryl-1h-indole-2-carboxamides, leur preparation et leur application en therapeutique
WO2009023623A1 (en) * 2007-08-10 2009-02-19 H, Lundbeck A/S Heteroaryl amide analogues
US8288397B2 (en) 2007-12-17 2012-10-16 Janssen Pharmaceutica Nv Imidazolo-, oxazolo-, and thiazolopyrimidine modulators of TRPV1
FR2926554B1 (fr) * 2008-01-22 2010-03-12 Sanofi Aventis Derives de carboxamides azabicycliques, leur preparation et leur application en therapeutique
FR2926555B1 (fr) 2008-01-22 2010-02-19 Sanofi Aventis Derives bicycliques de carboxamides azabicycliques, leur preparation et leur application en therapeutique
FR2926556B1 (fr) * 2008-01-22 2010-02-19 Sanofi Aventis Derives de carboxamides n-azabicycliques, leur preparation et leur application en therapeutique
US20100210682A1 (en) * 2009-02-19 2010-08-19 Abbott Laboratories Repeated Dosing of TRPV1 Antagonists
FR3007850B1 (fr) 2013-06-28 2015-07-17 Probayes Systeme de prediction de temperature

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NZ330818A (en) * 1996-02-13 2000-05-26 Abbott Lab Benzo-1, 3-dioxolyl- and benzofuranyl substituted pyrrolidine derivatives as endothelin antagonists
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FR2874015B1 (fr) * 2004-08-05 2006-09-15 Sanofi Synthelabo Derives de n-(1h-indolyl)-1h-indole-2-carboxamides, leur preparation et leur application en therapeutique
FR2880625B1 (fr) * 2005-01-07 2007-03-09 Sanofi Aventis Sa Derives de n-(heteroaryl)-1h-indole-2-carboxamides, leur preparation et leur application en therapeutique

Also Published As

Publication number Publication date
NO20071198L (no) 2007-03-02
CA2576727C (fr) 2013-11-26
CN101010297A (zh) 2007-08-01
US7384969B2 (en) 2008-06-10
EA200700400A1 (ru) 2007-06-29
US7582671B2 (en) 2009-09-01
JP2008509113A (ja) 2008-03-27
CN101010297B (zh) 2011-07-27
UY29046A1 (es) 2006-03-31
ZA200700999B (en) 2008-06-25
PT1776340E (pt) 2009-02-20
IL180911A0 (en) 2007-07-04
TW200616954A (en) 2006-06-01
ATE416160T1 (de) 2008-12-15
DK1776340T3 (da) 2009-04-06
US20090286846A1 (en) 2009-11-19
KR20070044000A (ko) 2007-04-26
RS50853B (sr) 2010-08-31
FR2874015B1 (fr) 2006-09-15
CY1108816T1 (el) 2014-04-09
PE20060557A1 (es) 2006-08-07
US20070149602A1 (en) 2007-06-28
EA011714B1 (ru) 2009-04-28
HK1110308A1 (en) 2008-07-11
TWI360538B (en) 2012-03-21
US7781477B2 (en) 2010-08-24
IL180911A (en) 2011-06-30
HRP20090101T3 (en) 2009-03-31
US20080227843A1 (en) 2008-09-18
EP1776340A1 (fr) 2007-04-25
ME01663B (me) 2010-08-31
AR050283A1 (es) 2006-10-11
DE602005011450D1 (de) 2009-01-15
TNSN07041A1 (fr) 2008-06-02
KR101215162B1 (ko) 2012-12-24
SI1776340T1 (sl) 2009-04-30
CR8889A (es) 2007-10-01
NZ552924A (en) 2010-08-27
AU2005279085A1 (en) 2006-03-09
MY139286A (en) 2009-09-30
WO2006024776A1 (fr) 2006-03-09
CA2576727A1 (fr) 2006-03-09
JP5100381B2 (ja) 2012-12-19
MX2007001436A (es) 2007-04-19
FR2874015A1 (fr) 2006-02-10
EP1776340B1 (fr) 2008-12-03
ES2318542T3 (es) 2009-05-01
MA28845B1 (fr) 2007-09-03
ECSP077215A (es) 2007-02-28
BRPI0513087A (pt) 2008-04-22
PL1776340T3 (pl) 2009-05-29
AU2005279085B2 (en) 2011-06-16
NO340060B1 (no) 2017-03-06

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